CN106478149A - A kind of piezoelectric with anti-microbial property and preparation method and application - Google Patents
A kind of piezoelectric with anti-microbial property and preparation method and application Download PDFInfo
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- CN106478149A CN106478149A CN201610817964.4A CN201610817964A CN106478149A CN 106478149 A CN106478149 A CN 106478149A CN 201610817964 A CN201610817964 A CN 201610817964A CN 106478149 A CN106478149 A CN 106478149A
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
- C04B41/80—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone of only ceramics
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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Abstract
The invention belongs to medical antibacterial field of material technology, discloses a kind of piezoelectric with anti-microbial property and preparation method and application.The piezoelectric with anti-microbial property is ceramic material to be carried out polarization obtain；The ceramic material is one or more in piezoceramic material.The piezoelectric of the present invention has good piezoelectricity, good biocompatibility, and safe, good stability antibacterial activity is notable.The piezoelectric is widely used in that medical science is antibacterial, sterilization material field, the effect with long acting antibiotic.
Description
Technical field
The invention belongs to antibiotic material in medical use technical field, more particularly to a kind of piezoceramic material with anti-microbial property
And preparation method and application.
Background technology
At present, clinically medical embedded material has extensive answering for repairing bone defect, skin wound, dent trauma etc.
With, but infected phenomenon especially microbial bacterial, such as large intestine is often produced in implantation process and after being implanted into
The infection of bacillus, staphylococcus aureus etc., this often result in body tissue pathology, bring secondary pain, serious prestige to patient
Coerce the physical and mental health of the mankind.Therefore it is then to solve a clinical key for being implanted into infection problems to prepare antibiotic material in medical use.Existing
In being all using material in most of anti-biotic materials or material surface metal ion dissolution come antibacterial, such as carry silver-colored, copper-loaded, resist
Bacterium effect is fine, and these metal ions being loaded into more or less can all have certain harm to human body, and preparation is difficult.
For the shortcoming existing for metal ion antibacterial, it is increasing that Recent study relies on material subjective antisepsis to be subject to
Concern.
Content of the invention
In order to overcome the shortcoming of above-mentioned existing technology and deficiency, the primary and foremost purpose of the present invention is to provide one kind with anti-
The piezoelectric of bacterium performance.The present invention essentially consists in the material body high and environmentally friendly using good stability, mechanical strength
Piezoelectricity reaches the strong effect of antibiotic property.
Another object of the present invention is to providing by the preparation method of the above-mentioned piezoelectric with anti-microbial property.
It is still another object of the present invention to provide the application of the above-mentioned piezoelectric with anti-microbial property.Described with antibacterial
The piezoelectric of performance is used for antibiotic material in medical use and/or medical implant material, particularly medical antibacterial implant material.
The purpose of the present invention is realized by following technological means：
A kind of piezoelectric with anti-microbial property is ceramic material to be carried out polarization obtain.
The ceramic material is piezoceramic material.
The ceramic material be preferably in potassium-sodium niobate, Lithium Sodium Niobate, lithium sodium kalium niobate class pottery or barium titanate a kind of with
On.
The piezoelectric constant of the piezoelectric with anti-microbial property be 5pC/N～150pC/N, preferably 10pC/N～
100pC/N；According to polarization direction, piezoelectric constant be on the occasion of or negative value, i.e.+5pC/N～+150pC/N, -5pC/N～-
150pC/N, preferably+10pC/N～+100pC/N, -10pC/N～-100pC/N.
The preparation method of the piezoelectric with anti-microbial property, specifically includes following steps：
Ceramic material is polarized using DC voltage, is obtained the piezoelectric with anti-microbial property.The polarization
Temperature is 25～120 DEG C；The normal temperature that is polarized to polarizes or high-temperature poling, and the temperature of the high-temperature poling is 40～120 DEG C, often
The temperature of temperature polarization is 25～35 DEG C.The polarization time is 1～60min.The DC voltage is 0.5kV～5kV.The pole
Change using copper sheet as electrode.
The piezoelectric with anti-microbial property is used for antibiotic material in medical use and/or medical implant material, particularly
Medical antibacterial implant material.
The purpose of the present invention is the piezoelectricity itself having using piezoceramic materials such as potassium-sodium niobates, that is, be subject to body
Electric charge is produced during the effect of mechanical force, so as to the effect of antibacterial be reached to improve the implantation efficiency of embedded material.
In the antibacterial piezoelectric, by taking potassium sodium niobate ceramic as an example, it is the transformation of Emission in Cubic and Tetragonal, in having
Heart dissymmetrical structure, causes polarised direction in pottery different, produces piezoelectricity.And its unleaded, good stability, with good
Biocompatibility and mechanical performance, can promote protein adsorption and cell adherence, be a kind of good embedded material.While in human body
It is a complicated electricity environment again, is that the root of piezo-electric effect is located, piezo-electric effect growth, reconstruction and damage also in bone is repaiied
Play an important role in multiple.Therefore environmentally friendly leadless piezoelectric ceramics anti-biotic material is greatly developed, with great
Society and economic implications.After polarization, the electricdomain of material internal is changed into piezoelectric by rambling state before
Towards the state of specific direction, material is caused to reach preferable antibacterial effect with higher piezoelectric constant.
The antibacterial piezoelectric of the present invention carrys out antibacterial not based on the extraneous metal ion for introducing, organic antibacterial agent etc., but
Piezoceramic material is relied in the presence of polarizing voltage, with piezoelectricity, rely on the mechanical pressure of body and electric charge is produced, to
Surrounding tissue produces electric signal, it is not required that external power, is good electroactive material.
The present invention has advantage following prominent：
(1) the piezoelectric process is simple with anti-microbial property of the present invention, good stability, mechanical performance are high, not leaded
Pollution-free and biocompatibility is good；
(2) piezoelectric with anti-microbial property of the present invention is produced potential when acting on by body mechanical force, no
Extraneous power supply is needed just to reach the effect of long acting antibiotic；
(3) preparation method of the piezoelectric with anti-microbial property of the present invention is simple to operate, and relies on upper and lower copper sheet
As electrode, metal others impurity is not introduced, pollution-free；
(4) bactericidal effect that the piezoelectric with anti-microbial property of the present invention is produced under different polarization conditions differs
Sample, the regulation of polarization condition is convenient, easily reach.
Description of the drawings
Fig. 1 is the antibiotic rate block diagram of the anti-microbial property of the piezoelectric prepared by embodiment 1～6, the pressure of piezoelectric
Electric constant be all on the occasion of.
Specific embodiment
The antibacterial effect present invention and the present invention reached with reference to specific embodiment is made further concrete detailed
Description, but embodiments of the present invention not limited to this, for the technological parameter especially not indicated, can refer to routine techniques is carried out.
Embodiment 1
A kind of piezoelectric:The unpolarized piezoelectric constant for processing potassium sodium niobate ceramic is 0pC/N.
Embodiment 2
A kind of preparation method of the piezoelectric with anti-microbial property, comprises the following steps：
Potassium sodium niobate ceramic material (a diameter of 10mm, thickness are 3mm) is carried out using DC voltage in 120 DEG C of oil baths
Polarization, obtains the piezoelectric with anti-microbial property；The DC polarization voltage 0.75kV/cm, polarization time are 5min, up and down
Copper sheet is the electrode of polarization.According to the difference of polarised direction, the piezoelectric constant of the piezoelectric is about+10pC/N, -10pC/
N.
Embodiment 3
A kind of preparation method of the piezoelectric with anti-microbial property, comprises the following steps：
Potassium sodium niobate ceramic material is polarized using DC voltage in 120 DEG C of oil baths, is obtained with anti-microbial property
Piezoelectric；The DC polarization voltage is 1.0kV/cm, and the polarization time is 5min, and upper and lower copper sheet is the electrode of polarization.Root
According to the difference of polarised direction, the piezoelectric constant of the piezoelectric is about+30pC/N, -30pC/N.
Embodiment 4
A kind of preparation method of the piezoelectric with anti-microbial property, comprises the following steps：
Potassium sodium niobate ceramic material is polarized using DC voltage in 120 DEG C of oil baths, is obtained with anti-microbial property
Piezoelectric；The DC polarization voltage is respectively 1.25kV/cm, and the polarization time is 30min, and upper and lower copper sheet is the electricity of polarization
Pole.According to the difference of polarised direction, the piezoelectric constant of the piezoelectric is about+50pC/N, -50pC/N.
Embodiment 5
A kind of preparation method of the piezoelectric with anti-microbial property, comprises the following steps：
Potassium sodium niobate ceramic material is polarized using DC voltage at 120 DEG C, is obtained the piezoelectricity with anti-microbial property
Material；The DC polarization voltage is 1.5kV/cm, and the polarization time is 10min, and upper and lower copper sheet is the electrode of polarization.According to polarization
The difference in direction, the piezoelectric constant of the piezoelectric are about+70pC/N, -70pC/N.
Embodiment 6
A kind of preparation method of the piezoelectric with anti-microbial property, comprises the following steps：
Potassium sodium niobate ceramic material is polarized using DC voltage at 120 DEG C, is obtained the piezoelectricity with anti-microbial property
Material；The DC polarization voltage is 2.0kV/cm, and the polarization time is 5min, and upper and lower copper sheet is the electrode of polarization.According to polarization
The difference in direction, the piezoelectric constant of the piezoelectric are about+90pC/N, -90pC/N.
Embodiment 7
A kind of preparation method of the piezoelectric with anti-microbial property, comprises the following steps：
Potassium sodium niobate ceramic material (a diameter of 10mm, thickness are 3mm) is polarized using DC voltage at 30 DEG C, is obtained
Arrive the piezoelectric with anti-microbial property；The DC polarization voltage is 1.0kV/cm, and the polarization time is 5min, and upper and lower copper sheet is
The electrode of polarization.According to the difference of polarised direction, the piezoelectric constant of the piezoelectric is about+10pC/N, -10pC/N.
Embodiment 8
A kind of preparation method of the piezoelectric with anti-microbial property, comprises the following steps：
Potassium sodium niobate ceramic material is polarized using DC voltage at 90 DEG C, is obtained the piezoresistive material with anti-microbial property
Material；The DC polarization voltage is 2.0kV/cm, and the polarization time is 5min, and upper and lower copper sheet is the electrode of polarization.According to polarization side
To difference, the piezoelectric constant of the piezoelectric is about+60pC/N, -60pC/N.
9 antibacterial effect of embodiment is tested
While in order to verify antibacterial effect that the present invention reaches, specific antibacterial experiment scheme is as follows：
Step one, the configuration of fluid nutrient medium
High salt formula is used, by made comprising following components：Deionized water, tryptone (tryptone), chlorine
Compound (NaCl), yeast extract (yeast extract)；
Step 2, the passing on of bacterium
Using bacterium bacterium and fluid nutrient medium blending culture, passed on twice with identical condition；
Step 3, the configuration of solid medium
By made comprising following components：Deionized water, agar；
Step 4, a kind of rhyme scheme in Chinese operas serving as the prelude to a complete score for voices
It is stand-by that the solid medium that step 3 high temperature is sterilized pours cooling shaping in culture dish into；
Step 5, material are co-cultured with bacterium
(1) gradient dilution becomes the 1/2 of original bacteria liquid concentration, 1/4,1/8,1/16,1,/32 five kind of bacterium solution；
(2) and configured with OD value=0.1 as suitable bacterial concentration in criterion calculation experiment；
(3) bacterium solution obtained in (2) is added to and is placed with piezoelectric (piezoelectric prepared by embodiment 1～6)
Co-culture in orifice plate；
Step 6, coated plate
The bacterium solution obtained in step 5 (4) is uniformly coated in the culture base table of cooling shaping in step 4 using spreading rod
It is put in behind face in constant incubator and cultivates；
Step 7, colony counting
Through culture, bred by each single cells grown and macroscopic bacterium colony is formed, clump count is counted, dilute according to which
Release multiple and sampling inoculum concentration by converse in sample containing bacterium number.
The method of described antibacterial experiment, the constituent deionized water of fluid nutrient medium in step one：Tryptone：Chlorine
Compound：The ratio of yeast extract is 200：2：2：1；Fluid nutrient medium sterilization time 2h, sterilising temp are 120 DEG C.
The method of described antibacterial experiment, needs to pass on twice in step 2, and first time, sub-culturing bacteria was with original bacteria liquid：Liquid
Culture medium=1：100 recovery bacteriums are put in 8-10 hour of culture in 37 DEG C of shaking tables, then again in the same way to for the first time
The bacterium of recovery carries out second pass culture.
The method of described antibacterial experiment, solid medium component agar in step 3：The ratio of deionized water is 4：125
～4.25：125；Solid medium sterilization time 2h, sterilising temp are 120 DEG C.
The method of described antibacterial experiment, in step 4, a kind of rhyme scheme in Chinese operas serving as the prelude to a complete score for voices temperature of solid medium is 60 DEG C -85 DEG C, solid culture
The height of base is the 1/2-2/3 of culture dish height.
The method of described antibacterial experiment, in step 5, (1) takes 1/32,1/16,1/8,1/4,1/2 successively from Cmin
The bacterium solution of concentration, is put in 5 holes of orifice plate, surveys the OD value in 6 holes after leaving a blank well, with OD value as 0.1 for mark
Standard, selects the corresponding concentration in hole that two OD values are close to 0.1, the concentration of the bacterium solution required for can trying to achieve；In step (3) bacterium solution and
Material co-cultures 8h, 12h or 24h in 37 DEG C of incubators.
The method of described antibacterial experiment, the bacterial concentration in step 6 required for coated plate are dilutions in (3) in step 5
Generally 100 times, 1000 times, 10000 times, 100000 times, 1000000 times, 10000000 times of multiple.
The method of described antibacterial experiment, selects culture dish of the clump count between 30-300 to carry out bacterium colony meter in step 7
Number, then contrasts each material clump count, the anti-microbial property of illustrative material.The antibacterial of the piezoelectric prepared by embodiment 1～6
The performance test results are as shown in Figure 1.
The above embodiment of the present invention is only intended to clearly illustrate the example lifted by the present invention, and be not to the present invention
The restriction of embodiment, can also make other changes in different forms on the basis of the field described above,
This does not repeat one by one.All any modification, equivalent and improvement that is made within the spirit and principles in the present invention etc., all should wrap
It is contained within the protection domain of the claims in the present invention.
Claims (9)
1. a kind of piezoelectric with anti-microbial property, it is characterised in that：It is ceramic material to be carried out polarization obtain；The pottery
Material is one or more in piezoceramic material.
2. there is the piezoelectric of anti-microbial property according to claim 1, it is characterised in that：The ceramic material is potassium niobate
Sodium, Lithium Sodium Niobate, lithium sodium kalium niobate class pottery or barium titanate in more than one.
3. there is the piezoelectric of anti-microbial property according to claim 1, it is characterised in that：The pressure with anti-microbial property
The piezoelectric constant of electric material is 5pC/N～150pC/N.
4. there is the piezoelectric of anti-microbial property according to claim 3, it is characterised in that：The pressure with anti-microbial property
The piezoelectric constant of electric material is 10pC/N～100pC/N.
5. the preparation method of the piezoelectric according to any one of Claims 1 to 4 with anti-microbial property, it is characterised in that tool
Body is comprised the following steps：
Ceramic material is polarized using DC voltage, is obtained the piezoelectric with anti-microbial property.
6. there is the preparation method of the piezoelectric of anti-microbial property according to claim 5, it is characterised in that：During the polarization
Between be 1～60min；The DC voltage is 0.5kV～5kV.
7. there is the preparation method of the piezoelectric of anti-microbial property according to claim 5, it is characterised in that：The polarization
Temperature is 25～120 DEG C；The polarization is using copper sheet as electrode.
8. the application of the piezoelectric according to any one of Claims 1 to 4 with anti-microbial property, it is characterised in that：Described
Piezoelectric with anti-microbial property is used for antibiotic material in medical use and/or medical implant material.
9. application according to claim 8, it is characterised in that：The piezoelectric with anti-microbial property is used for medical anti-
Bacterium implant material.
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107721420A (en) * | 2017-09-06 | 2018-02-23 | 华南理工大学 | A kind of cupric oxide doped potassium-sodium niobate antibacterial piezoelectric ceramics implant and its preparation and application |
| CN107802878A (en) * | 2017-09-06 | 2018-03-16 | 华南理工大学 | A kind of modified gelatin/potassium-sodium niobate compound electroactive antibacterial biological dressing and its preparation and application |
| CN108794003A (en) * | 2018-07-17 | 2018-11-13 | 华南理工大学 | A kind of biological glass ceramic and preparation method thereof of doping potassium-sodium niobate |
| CN109477258A (en) * | 2017-05-31 | 2019-03-15 | 株式会社村田制作所 | Cloth and silk and liquid absorption article |
| CN109485418A (en) * | 2018-12-14 | 2019-03-19 | 华南理工大学 | A kind of potassium-sodium niobate-based piezoelectric material of high efficiency anti-tumor and the preparation method and application thereof |
| CN109704809A (en) * | 2018-12-14 | 2019-05-03 | 华南理工大学 | A kind of antitumor material of piezoelectricity and the preparation method and application thereof |
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| CN115286883A (en) * | 2022-09-30 | 2022-11-04 | 北京大学口腔医学院 | Method for regulating antibacterial activity and application |
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| CN109477258A (en) * | 2017-05-31 | 2019-03-15 | 株式会社村田制作所 | Cloth and silk and liquid absorption article |
| CN107802878A (en) * | 2017-09-06 | 2018-03-16 | 华南理工大学 | A kind of modified gelatin/potassium-sodium niobate compound electroactive antibacterial biological dressing and its preparation and application |
| CN107721420A (en) * | 2017-09-06 | 2018-02-23 | 华南理工大学 | A kind of cupric oxide doped potassium-sodium niobate antibacterial piezoelectric ceramics implant and its preparation and application |
| CN107802878B (en) * | 2017-09-06 | 2020-07-28 | 华南理工大学 | Modified gelatin/potassium-sodium niobate composite electroactive antibacterial biological dressing and preparation and application thereof |
| WO2019227835A1 (en) * | 2018-05-31 | 2019-12-05 | 华南理工大学 | Bone implantation material with micro-region potential difference and preparation method therefor |
| CN108794003A (en) * | 2018-07-17 | 2018-11-13 | 华南理工大学 | A kind of biological glass ceramic and preparation method thereof of doping potassium-sodium niobate |
| CN108794003B (en) * | 2018-07-17 | 2021-03-30 | 华南理工大学 | Potassium-sodium niobate-doped bioglass ceramic and preparation method thereof |
| CN109485418A (en) * | 2018-12-14 | 2019-03-19 | 华南理工大学 | A kind of potassium-sodium niobate-based piezoelectric material of high efficiency anti-tumor and the preparation method and application thereof |
| CN109704809A (en) * | 2018-12-14 | 2019-05-03 | 华南理工大学 | A kind of antitumor material of piezoelectricity and the preparation method and application thereof |
| CN109485418B (en) * | 2018-12-14 | 2021-07-20 | 华南理工大学 | Efficient anti-tumor potassium-sodium niobate-based piezoelectric material and preparation method and application thereof |
| CN109704809B (en) * | 2018-12-14 | 2022-01-18 | 华南理工大学 | Piezoelectric anti-tumor material and preparation method and application thereof |
| CN110173895A (en) * | 2019-05-22 | 2019-08-27 | 海信(广东)厨卫系统有限公司 | A kind of water heater and production method with sterilizing function |
| CN110173895B (en) * | 2019-05-22 | 2023-10-17 | 海信(广东)厨卫系统有限公司 | Water heater with sterilization function and manufacturing method |
| CN114702305A (en) * | 2022-03-25 | 2022-07-05 | 佛山(华南)新材料研究院 | Transparent ceramic capable of sterilizing and self-cleaning for radio frequency beauty instrument and preparation method thereof |
| CN115286883A (en) * | 2022-09-30 | 2022-11-04 | 北京大学口腔医学院 | Method for regulating antibacterial activity and application |
| CN116462410A (en) * | 2023-04-20 | 2023-07-21 | 清远市简一陶瓷有限公司 | Negative ion antibacterial glaze, marble tile and preparation method thereof |
| CN116768615A (en) * | 2023-06-21 | 2023-09-19 | 中山火炬职业技术学院 | Electroactive bone repair material capable of responding to ultrasonic mechanical stimulus and preparation method thereof |
| CN116768615B (en) * | 2023-06-21 | 2024-06-07 | 中山火炬职业技术学院 | Electroactive bone repair material capable of responding to ultrasonic mechanical stimulus and preparation method thereof |
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