CN106474340A - 一种含山茶提取物的防牙痛口服液 - Google Patents
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Abstract
本发明提供一种含山茶提取物的防牙痛口服液,对牙周炎引起的牙痛具有显著预防、治疗效果。其原料组成为:山茶提取物30‑50份、金银花20‑30份、黄连1‑5份、紫花地丁10‑15份、麦冬20‑25份、固齿膏3‑8份。此口服液生产方法简单、成本低廉且具有清胃泄热、益肾固齿的功效,可作为居家常备口服制剂使用。
Description
技术领域
本发明涉及一种含山茶提取物的防牙痛口服液,属于中草药口服制剂领域。
背景技术
牙周炎主要是由局部因素引起的牙周支持组织的慢性炎症。如未能及时治疗,炎症可由牙龈向深层扩散到牙周膜、牙槽骨和牙骨质而发展为牙周炎。由于早期多无明显自觉症状而已被忽视,待有症状时已较为严重,甚至无法保留牙齿。因而必须及时就诊展开治疗。牙周炎的主要病因为菌斑,菌斑是粘附于牙齿表面的微生物群,不能用漱口、水冲洗等方法去除。其次为牙石,牙石是指沉积在牙面上的矿化的菌斑,根据其沉积部位和性质分为龈上牙石和龈下牙石两种,牙石构成了菌斑附着和细菌滋生的良好环境。再者为创伤性咬合,指在咬合时,咬合力过大或异常,超越了牙周组织所能承受的合力,致使牙周组织发生损伤的咬合称之;创伤性咬合包括咬合时的早接触、牙合干扰、夜间磨牙等。其他如食物嵌塞、不良修复体、口呼吸等因素也促使牙周组织验证的发生。同时,全身易感因素,如遗传因素、内分泌紊乱、免疫功能缺陷、某些系统疾病、精神压力等也是其发病基本因素。牙周炎可引发牙周袋的形成,使牙周溢脓甚至牙齿松动;患者常感钝痛。
对于牙周炎治疗,西医常使用机械清除菌斑和牙石的方法,包括洁治、刮治、根面平整等,是治疗牙周炎、防止其复发的最主要的、简单而有效的手段。同时配合药物治疗,包括全身药物治疗和局部药物治疗,全身药物治疗常使用抗菌药物,如硝基咪唑类药物甲硝唑、替硝唑等;局部用药主要有含漱药物、局部消炎收敛药、抗菌药物冲洗、缓释及控释局部抗菌药物。但这些治疗方法存在治疗效果不佳、易复发、副作用显著、长期治疗效果差、可能引发过敏等不足之处。
现代中医学认为“肾虚火旺为内因,湿热为外因”是牙周炎的主要病因,此学说主要从集体全身状况、外部环境两方面综合阐述了牙周炎的病因。因此本发明从中草药入手,提供一种含有山茶提取物的防牙痛口服液,可有效预防、治疗牙周炎引起的牙痛症状。
发明内容
本发明的目的在于提供一种含山茶提取物的防牙痛口服液,适合牙周炎引发牙痛患者或者有轻微上火症状的人群服用。
为实现上述目的,本发明采用如下技术方案:
一种含山茶提取物的防牙痛口服液,其特征在于:包括以下重量份原料:山茶提取物30-50份、金银花20-30份、黄连1-5份、紫花地丁10-15份、麦冬20-25份、固齿膏3-8份。
优选的,一种含山茶提取物的防牙痛口服液,其特征在于:包括以下重量份原料:山茶提取物38份、金银花22份、黄连3份、紫花地丁12份、麦冬20份、固齿膏5份。
其中,所述山茶提取物为山茶皂苷、山茶黄酮类提取物,其提取方法为:
(1)山茶花洗净沥干,加入6-10倍体积的60-80%vol的乙醇,80℃下浸提20min,过0.45um滤膜,减压蒸馏后经大孔树脂吸附,用80%乙醇洗脱,洗脱液经减压浓缩冷冻干燥得山茶花多酚粉末;
(2)山茶皂素的提取:取山茶树叶及梗,洗净粉碎至毫米级大小,加入60-80%vol的乙醇,于60℃下浸提2h,得皂素粗提液,后经体积排阻色谱分离并冷冻干燥得到山茶皂素粉末。
本发明的另一目的是提供一种制备上述含山茶提取物的防牙痛口服液的方法,其具体步骤为:
(1)取上述重量份的金银花、黄连、紫花地丁、麦冬以及固齿膏,加入1-2倍体积的水,文火煎煮至液体体积减半,再加入3-5倍体积的水,再文火煎煮2h;
(2)上述药汤过滤除药渣,加入上述重量份的山茶提取物,使之充分溶解;
(3)步骤(2)所得药汤装瓶即可。
植物多酚:多酚能够清楚与多种疾病有关的自由基。多酚具有抗氧化、抗菌、抗病毒、抗炎症等作用,因此其可抑制真菌、病毒和细菌的生长,同时内服可消除体内炎症。多酚对微生物的抑制作用机理可能是多种因素作用的结果,如抑制病原菌微生物的粘附、竞争抑制作用、直接破坏细胞结构等。茶多酚还可有效抑制内皮细胞功能紊乱,并能有效抑制心血管疾病的发展;摄入多酚类物质可加强免疫细胞功能。
山茶皂素:是一种纯天然非离子型表面活性剂,具有抗菌、抗炎、抗高血压等作用,还具有较好的解酒精中毒之功效。
本发明的优点在于:
本发明从中草药入手,提供一种含有山茶提取物的防牙痛口服液,可有效预防、治疗牙周炎引起的牙痛症状。避免了传统药物治疗效果不佳、易复发、副作用显著、长期治疗效果差、可能引发过敏等不足之处。
具体实施方式
实施例1
一种含山茶提取物的防牙痛口服液,包括以下重量份原料:山茶提取物38份、金银花22份、黄连3份、紫花地丁12份、麦冬20份、固齿膏5份。
其中,所述山茶提取物为山茶皂苷、山茶黄酮类提取物,其提取方法为:
(1)山茶花洗净沥干,加入9倍体积的70%vol的乙醇,80℃下浸提20min,过0.45um滤膜,减压蒸馏后经大孔树脂吸附,用80%乙醇洗脱,洗脱液经减压浓缩冷冻干燥得山茶花多酚粉末;
(2)山茶皂素的提取:取山茶树叶及梗,洗净粉碎至毫米级大小,加入70%vol的乙醇,于60℃下浸提2h,得皂素粗提液,后经体积排阻色谱分离并冷冻干燥得到山茶皂素粉末。
本发明的另一目的是提供一种制备上述含山茶提取物的防牙痛口服液的方法,其具体步骤为:
(1)取上述重量份的金银花、黄连、紫花地丁、麦冬以及固齿膏,加入1.5倍体积的水,文火煎煮至液体体积减半,再加入4倍体积的水,再文火煎煮2h;
(2)上述药汤过滤除药渣,加入上述重量份的山茶提取物,使之充分溶解;
(3)步骤(2)所得药汤装瓶即可。
实施例2
一种含山茶提取物的防牙痛口服液,包括以下重量份原料:山茶提取物30份、金银花30份、黄连5份、紫花地丁12份、麦冬20份、固齿膏3份。
其中,所述山茶提取物为山茶皂苷、山茶黄酮类提取物,其提取方法为:
(1)山茶花洗净沥干,加入8倍体积的60%vol的乙醇,80℃下浸提20min,过0.45um滤膜,减压蒸馏后经大孔树脂吸附,用60%乙醇洗脱,洗脱液经减压浓缩冷冻干燥得山茶花多酚粉末;
(2)山茶皂素的提取:取山茶树叶及梗,洗净粉碎至毫米级大小,加入60%vol的乙醇,于60℃下浸提2h,得皂素粗提液,后经体积排阻色谱分离并冷冻干燥得到山茶皂素粉末。
本发明的另一目的是提供一种制备上述含山茶提取物的防牙痛口服液的方法,其具体步骤为:
(1)取上述重量份的金银花、黄连、紫花地丁、麦冬以及固齿膏,加入1倍体积的水,文火煎煮至液体体积减半,再加入3倍体积的水,再文火煎煮2h;
(2)上述药汤过滤除药渣,加入上述重量份的山茶提取物,使之充分溶解;
(3)步骤(2)所得药汤装瓶即可。
实施例3
一种含山茶提取物的防牙痛口服液,包括以下重量份原料:山茶提取物31份、金银花20份、黄连1份、紫花地丁15份、麦冬25份、固齿膏8份。
其中,所述山茶提取物为山茶皂苷、山茶黄酮类提取物,其提取方法为:
(1)山茶花洗净沥干,加入8倍体积的60%vol的乙醇,80℃下浸提20min,过0.45um滤膜,减压蒸馏后经大孔树脂吸附,用60%乙醇洗脱,洗脱液经减压浓缩冷冻干燥得山茶花多酚粉末;
(2)山茶皂素的提取:取山茶树叶及梗,洗净粉碎至毫米级大小,加入60%vol的乙醇,于60℃下浸提2h,得皂素粗提液,后经体积排阻色谱分离并冷冻干燥得到山茶皂素粉末。
本发明的另一目的是提供一种制备上述含山茶提取物的防牙痛口服液的方法,其具体步骤为:
(1)取上述重量份的金银花、黄连、紫花地丁、麦冬以及固齿膏,加入2倍体积的水,文火煎煮至液体体积减半,再加入5倍体积的水,再文火煎煮2h;
(2)上述药汤过滤除药渣,加入上述重量份的山茶提取物,使之充分溶解;
(3)步骤(2)所得药汤装瓶即可。
实施例4
随机选择240例25-40岁的牙周炎患者作为实验对象,病程7天及以上,其中也包括病程数年患者;患者症状为口臭、牙痛、红肿、牙龈出血等。将患者随机分为3组,分别为空白组、对照组以及试验组。
其中,试验组口服本发明所述含山茶提取物的牙痛口服液,每日3次,每次15mL,期间配合菌斑、牙石治疗,用药时间持续15d。对照组服用替硝唑片,每日3次,每次1片,期间配合菌斑、牙石治疗,用药时间持续15d。空白组服用无糖凉茶,每日3次,每次15mL,期间配合菌斑、牙石治疗,治疗时间持续15d。
疗效判定标准:①局部红肿、出血消失;②口臭、牙疼症状消失;③牙周袋、牙齿松动现象消失。同时达到上述3种效果为治疗效果显著,具备1-2项作用为有用,否则为无效。试验结果见表1。
表1 牙周炎治疗效果统计
相对于空白组而言,药物治疗效果显著;这说明菌斑、牙石刮除的纯物理治疗无法根除牙齿上着生的细菌,该方法易复发。而同时服用替硝唑片则具有一定的疗效;配合本发明的防牙痛口服液则效果显著。
以上所述仅为本发明的较佳实施例,凡依本发明申请专利范围所做的均等变化与修饰,皆应属本发明的涵盖范围。
Claims (3)
1.一种含山茶提取物的防牙痛口服液,其特征在于:包括以下重量份原料:山茶提取物30-50份、金银花20-30份、黄连1-5份、紫花地丁10-15份、麦冬20-25份、固齿膏3-8份。
2.如权利要求1所述的一种含山茶提取物的防牙痛口服液,其特征在于:所述山茶提取物为山茶皂苷、山茶黄酮类提取物,其提取方法为:
(1)山茶花洗净沥干,加入6-10倍体积的60-80%vol的乙醇,80℃下浸提20min,过0.45um滤膜,减压蒸馏后经大孔树脂吸附,用80%乙醇洗脱,洗脱液经减压浓缩冷冻干燥得山茶花多酚粉末;
(2)山茶皂素的提取:取山茶树叶及梗,洗净粉碎至毫米级大小,加入60-80%vol的乙醇,于60℃下浸提2h,得皂素粗提液,后经体积排阻色谱分离并冷冻干燥得到山茶皂素粉末。
3.一种含山茶提取物的防牙痛口服液,其特征在于:其制作方法为:
(1)取上述重量份的金银花、黄连、紫花地丁、麦冬以及固齿膏,加入1-2倍体积的水,文火煎煮至液体体积减半,再加入3-5倍体积的水,再文火煎煮2h;
(2)上述药汤过滤除药渣,加入上述重量份的山茶提取物,使之充分溶解;
(3)步骤(2)所得药汤装瓶即可。
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