CN106474123A - A kind of nanometer coptis plain piece - Google Patents
A kind of nanometer coptis plain piece Download PDFInfo
- Publication number
- CN106474123A CN106474123A CN201610772481.7A CN201610772481A CN106474123A CN 106474123 A CN106474123 A CN 106474123A CN 201610772481 A CN201610772481 A CN 201610772481A CN 106474123 A CN106474123 A CN 106474123A
- Authority
- CN
- China
- Prior art keywords
- berberine
- vitamin
- coptis
- plain piece
- auxiliary material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of nanometer coptis plain piece.Berberine Passive intake is poor, clinical practice is narrow.In order to solve this problem, the invention provides a kind of nanometer coptis plain piece, is made up of berberine, vitamin and auxiliary material, a diameter of nanoscale of the coptis particle, mass ratio is, berberine 10 20%, and vitamin 1 3%, remaining are auxiliary material.Human body is very good to the absorbability of vitamin, the combination of berberine and vitamin, makes also to absorb berberine when vitamin is absorbed, and solves the problems, such as that berberine is difficult and absorbs.The berberine tablet that the present invention is provided has good effect to hypertension, high fat of blood, hyperglycaemia.There is good effect.
Description
Technical field
The present invention relates to a kind of nanometer coptis plain piece.
Background technology
Berberine (jamaicin) is conventional antibiosis anti-inflammatory drug, is extracted or artificial synthesized from the Chinese medicines such as the coptis, golden cypress
Alkaloid, main component be jamaicin.His Small side effects, are administered orally safety, and medicine source is enriched, cheap, frequently as family
Indispensable medicine.Clinically it is mainly used in the treatment of the enterobacterial infection disease such as bacillary dysentery, enteritis.
In newest research, berberine also has following function, 1 treatment arrhythmia cordis, the intractable heart failure of 2 treatments
Exhaust, 3 Hypertensions, 4 treatment hyperlipidemias, 5 treatment arterial thrombus, 6 treatment diabetes, 7 treatment digestibilities are burst
Ulcer, 8 auxiliary for treating cancer are waited.Traditional handicraft is big factors for restricting berberine development, and the absorbability of berberine is not
Good and especially slow, for the enterobacterial infection disease such as heart failure, bacillary dysentery, enteritis be due to after berberine entrance
Can not absorb at once, until intestines can just be partially absorbed, be exactly the absorbability in intestines nor especially good, this is also the coptis
Above-described effect is have, but is never found, the reason for not also being widely used.
Content of the invention
1st, technical problem to be solved：
Berberine is absorbed slowly.
2nd, technical scheme：
In order to solve the problems, such as berberine absorption, the invention provides a kind of nanometer coptis plain piece, including berberine, by the coptis
Element, vitamin and auxiliary material composition, mass ratio is, berberine 10-20%, vitamin 1-3%, and remaining is auxiliary material, described berberine
A diameter of nanoscale of particle.
Mass ratio is that berberine 12-18%, vitamin 1.5-2.5%, remaining are auxiliary material.
Berberine 15%, vitamin 2%, remaining are auxiliary material.
Described auxiliary material is attapulgite.
The particle of the vitamin is diameter 1-3 or 3-5 micron.
The particle of attapulgite is 800-1000 mesh.
3rd, beneficial effect：
Human body is very good to the absorbability of vitamin, the combination of nanometer coptis element and vitamin, promotes human body absorbing vitamin
When berberine is also absorbed, solve the problems, such as that berberine is difficult and absorb.The berberine tablet that the present invention is provided is to hypertension, high blood
Fat, hyperglycaemia have good effect.
Specific embodiment
Below by embodiment, the present invention is described in detail.
Embodiment 1
One berberine tablet, wherein vitamin 10mg, berberine 200mg, remaining are attapulgite.Wherein described vitamin
Grain is diameter 3-5 micron.A diameter of nanoscale of described coptis crude granule.The particle of attapulgite is 800-1000 mesh.
Embodiment 2
One berberine tablet, wherein vitamin 30mg, berberine 100mg, remaining are attapulgite.Other are identical with embodiment.
Embodiment 3
One berberine tablet, wherein vitamin 20mg, berberine 150mg, remaining are attapulgite.Other are identical with embodiment.
Three above embodiment, as the particle of berberine is for nano level, and mixes with vitamin, in test
In, berberine and vitamin almost absorb together, have just been absorbed by the body less than intestines.
Although the present invention is disclosed as above with preferred embodiment, they be not for limiting the present invention, any ripe
This those skilled in the art is practised, without departing from the spirit and scope of the invention, can be made various changes or retouch from working as, therefore the guarantor of the present invention
Shield scope should be by being defined that claims hereof protection domain is defined.
Claims (6)
1. a kind of nanometer coptis plain piece, it is characterised in that：It is made up of berberine, vitamin and auxiliary material, mass ratio is, berberine
10-20%, vitamin 1-3%, remaining are auxiliary material, a diameter of nanoscale of described coptis crude granule.
2. nanometer coptis plain piece as claimed in claim 1, it is characterised in that:Mass ratio is, berberine 12-18%, vitamin
1.5-2.5%, remaining are auxiliary material.
3. nanometer coptis plain piece as claimed in claim 1, it is characterised in that:Mass ratio is, berberine 15%, vitamin 2%, its
Remaining for auxiliary material.
4. the nanometer coptis plain piece as described in claim 1-3 any claim, it is characterised in that:Described auxiliary material is concavo-convex
Rod soil.
5. the nanometer coptis plain piece as described in claim 1-3 any claim, it is characterised in that：The particle of the vitamin
For diameter 3-5 micron.
6. nanometer coptis plain piece as claimed in claim 4, it is characterised in that the particle of attapulgite is 800-1000 mesh.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610772481.7A CN106474123A (en) | 2016-08-31 | 2016-08-31 | A kind of nanometer coptis plain piece |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610772481.7A CN106474123A (en) | 2016-08-31 | 2016-08-31 | A kind of nanometer coptis plain piece |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106474123A true CN106474123A (en) | 2017-03-08 |
Family
ID=58273238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610772481.7A Pending CN106474123A (en) | 2016-08-31 | 2016-08-31 | A kind of nanometer coptis plain piece |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106474123A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020015622A1 (en) * | 2018-07-17 | 2020-01-23 | 中国人民解放军第四军医大学 | Effect of combination of bifidobacterium and berberine on pre-diabetes and type 2 diabetes |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1365676A (en) * | 2001-01-18 | 2002-08-28 | 杨孟君 | Nano medicine 'Compound berberine' and its preparing process |
| CN1476873A (en) * | 2002-08-20 | 2004-02-25 | 甘肃凯西生态环境工程有限公司 | Medicine composition for curing diarrhea |
| CN101601681A (en) * | 2009-04-07 | 2009-12-16 | 北京利千秋科技发展有限公司 | The pharmaceutical composition that is used for blood sugar lowering and blood fat |
-
2016
- 2016-08-31 CN CN201610772481.7A patent/CN106474123A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1365676A (en) * | 2001-01-18 | 2002-08-28 | 杨孟君 | Nano medicine 'Compound berberine' and its preparing process |
| CN1476873A (en) * | 2002-08-20 | 2004-02-25 | 甘肃凯西生态环境工程有限公司 | Medicine composition for curing diarrhea |
| CN101601681A (en) * | 2009-04-07 | 2009-12-16 | 北京利千秋科技发展有限公司 | The pharmaceutical composition that is used for blood sugar lowering and blood fat |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020015622A1 (en) * | 2018-07-17 | 2020-01-23 | 中国人民解放军第四军医大学 | Effect of combination of bifidobacterium and berberine on pre-diabetes and type 2 diabetes |
| CN112770749A (en) * | 2018-07-17 | 2021-05-07 | 中国人民解放军第四军医大学 | Application of combination of bifidobacterium and berberine in treating pre-diabetes and type 2 diabetes |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170308 |
|
| RJ01 | Rejection of invention patent application after publication |