CN106472521A - A kind of bactericidal composition and purposes containing benziothiazolinone with metrafenone - Google Patents
A kind of bactericidal composition and purposes containing benziothiazolinone with metrafenone Download PDFInfo
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- CN106472521A CN106472521A CN201610895681.1A CN201610895681A CN106472521A CN 106472521 A CN106472521 A CN 106472521A CN 201610895681 A CN201610895681 A CN 201610895681A CN 106472521 A CN106472521 A CN 106472521A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
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Abstract
The present invention relates to technical field of pesticide combination, discloses a kind of bactericidal composition containing benziothiazolinone and metrafenone.The bactericidal composition active ingredient is benziothiazolinone and metrafenone, and benziothiazolinone is 1 with the mass ratio of metrafenone：40‑40：1, active ingredient gross mass accounts for 1% the 80% of whole preparation gross mass, and remaining is auxiliary element.The bactericidal composition can be configured to missible oil, microemulsion, aqueous emulsion, suspending agent, dispersible oil-suspending agent, wettable powder, water dispersible granules, suspension seed-coating agent, water and milk seed coat agent, Seed Treatment and dispersible pulvis, Seed Treatment and dispersible granula.Bactericidal composition of the present invention has significant synergistic function, is mainly used in preventing and treating wheat, paddy rice, cucumber, grape, apple mildew.
Description
Technical field
The present invention relates to technical field of pesticide combination, and in particular to a kind of Bactericidal composite containing benziothiazolinone and metrafenone
Thing, is mainly used in preventing and treating wheat, paddy rice, cucumber, grape, apple mildew.
Technical background
Benziothiazolinone is a kind of efficient, low toxicity, and broad-spectrum germicide can destroy pathogen cell membrane protein and synthesis system
System, so as to suppress pathogen to breed, disturbs pathogen cell metabolism so as to physiologic derangement, causes pathogen dead.The change
To bacterium, fungus-caused multiple kinds of crops disease has good prevention effect to compound, and fool proof to crops and environment.
Metrafenone, chemical name are (3 bromine, 6 methoxyl group, 2 aminomethyl phenyl) (2,3,4 trimethoxy, 6 methylbenzene
Base) ketone is the Benzophenones bactericide of BASF Aktiengesellschaft's exploitation.The medicament is mainly used in cereal, grape, cucumber and apple
The crops such as fruit prevent and treat the diseases such as powdery mildew.As which has the mechanism of action of uniqueness, and receive publicity.
Powdery mildew, can be all fallen ill from seedling to heading.Mainly cause harm blade, also cause harm stem and tassel.Have a strong impact on light
Cooperation is used, and so that eubolism is interfered, is caused early ageing, and yield is affected, and causes economic loss.
Content of the invention
It is an object of the invention to provide a kind of bactericidal composition containing benziothiazolinone and metrafenone, synergistic effect is obvious.Anti-
Control powdery mildew effect is significant.In order to achieve the above object, the technical solution used in the present invention is：
A kind of bactericidal composition containing benziothiazolinone and metrafenone, wherein active ingredient benziothiazolinone and the mass ratio of metrafenone
For 1：40‐40：1.
Further, active ingredient gross mass accounts for 1% the 80% of whole preparation gross mass, and remaining is auxiliary element.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, the bactericidal composition can be processed into missible oil, micro emulsion
Agent, aqueous emulsion, suspending agent, dispersible oil-suspending agent, wettable powder, water dispersible granules, suspension seed-coating agent, water and milk seed coat agent,
Seed Treatment dispersibles pulvis, and Seed Treatment dispersibles granula.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, when missible oil is processed into, auxiliary element includes solvent,
Cosolvent, emulsifying agent.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, when microemulsion is processed into, auxiliary element includes molten
Agent, cosolvent, emulsifying agent and water.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, when aqueous emulsion is processed into, auxiliary element includes molten
Agent, cosolvent, emulsifying agent and water.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, when suspending agent is processed into, auxiliary element includes point
Powder, thickener, antifreezing agent, defoamer and water.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, when be processed into dispersible oil-suspending agent when, aid in into
Dividing includes solvent, antifreezing agent, emulsifying agent.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, when wettable powder is processed into, auxiliary element bag
Include wetting agent, dispersant, carrier.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, when water dispersible granules are processed into, auxiliary element bag
Include wetting agent, dispersant, binding agent, disintegrant.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, when suspending agent seed coat agent is processed into, auxiliary element
Including dispersant, antifreezing agent, film forming agent, thickener, defoamer, warning coloration, water.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, when water and milk seed coat agent is processed into, auxiliary element bag
Include solvent, cosolvent, emulsifying agent, film forming agent, warning coloration and water.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, when be processed into dispersible powder seed coat agent when, aid in into
Dividing includes dispersant, wetting agent, film forming agent, warning coloration, filler.
The above-mentioned bactericidal composition containing benziothiazolinone and metrafenone, when be processed into dispersible seed coat agent when, aid in into
Dividing includes dispersant, wetting agent, disintegrant, film forming agent, warning coloration, filler.
The above dispersant is naphthalene sulfonate, lignosulfonates, polycarboxylate, cyclohexanone formaldehyde condensation products, alkyl
Benzene sulfonate, APES, AEO, castor oil polyoxyethylene ether, AEO
One or more in formaldehyde condensation products sulfate；
The above emulsifying agent is APES, styrylphenol polyoxyethylene ether, polyoxyethylene nonyl phenyl second
Alkene ether, styrylphenol polyoxyethylene ether phosphate, aliphatic alcohol polyethenoxy ester, alkyl polyoxyethylene sulfate salt, phenethyl
One or more in phenol polyethenoxy polyethenoxy ether；
The above antifreezing agent is ethylene glycol, propane diols, glycerine, one or more in urea；
The above thickener is xanthans, Arabic gum, aluminium-magnesium silicate, polyvinyl alcohol, carboxymethylcellulose calcium, Guar
Glue, one or more in sodium alginate；
The above defoamer is organic silicone oil defoamer, 10 aliphatic alcohols compound of C8, in silicone defoamer
Plant or multiple.
The above solvent is cyclohexanone, dimethyldecamide, solvent naphtha, N methyl pyrrolidone, ethyl acetate, acetic acid
Secondary butyl ester, methyl oleate, turpentine oil, toluene, dimethylbenzene, phenmethylol, n-butanol, isopropanol, ethanol, methyl alcohol, in water equal solvent
One or more；
The above wetting agent is lauryl sodium sulfate, calcium dodecyl benzene sulfonate, pull open powder, Tea Saponin, alkylnaphthalene
One or more in the wetting agents such as sodium sulfonate；
The above binding agent is starch, carboxymethylcellulose calcium, polyvinyl alcohol, PEG 8000, and aluminium-magnesium silicate is organic
One or more in bentonite；
The above disintegrant is sodium sulphate, ammonium sulfate, urea, calcium nitrate, one or more in magnesium nitrate；
The above filler is white carbon, urea, sodium sulphate, ammonium sulfate, kaolin, precipitated calcium carbonate, bentonite, diatom
One or more in soil.
The warning coloration is selected from rose violet, rose-red, pinkish red, carmine, at least one in the color such as acid scarlet.
By further investigation, the present invention has found that benziothiazolinone and metrafenone carry out compounded combination and have obvious synergistic effect,
Powdery mildew effect is significant is prevented and treated, be can be used to wheat, paddy rice, cucumber, grape, apple mildew is prevented and treated, or prevent and treat for preparing
Wheat, paddy rice, cucumber, grape, the agricultural chemicals of apple mildew.
Specific embodiment
Inventor illustrates that by Toxicity Determination and field control effectiveness test benziothiazolinone and metrafenone are compounded to powdery mildew
Synergistic effect.
Preventive effect embodiment 1, prevent and treat the Toxicity Determination of powdery mildew of cucumber
Experimental technique is referred to《People's Republic of China's agricultural industry criteria NY/T1156.11-2008 agricultural chemicals indoor biological is surveyed
Determine the 11st part of test rule bactericide：Preventing and treating cucurbits powdery mildew test pot-culture method》.First single dose and each Mixed Pharmacy are arranged
5 variable concentrations.With the pure water added with a small amount of surfactant, wash and take the fresh spore covered with Powdery Mildew cucumber leaves
Son, is filtered with double gauze, and the suspension for making spore concentration for 1*105 spore/milliliter is standby.3 basins, 4 weights are often processed
Answer, and set the process for active ingredient not being contained containing only solvent and surfactant make blank.With spore suspension in medicament
Before processing 24h is inoculated with, and liquid is uniformly sprayed in blade face to all wettings, standby after liquid natural air drying.Inoculation and medicament
Potted plant cucumber natural air drying after process, then moves to thermostatic chamber, cultivates 7-10 days under conditions of temperature 20-24 degree.Treat sky
When white control disease leaf rate reaches more than 80%, classification investigation manages incidence everywhere, often processes at least 30 leaves of investigation, is classified mark
Standard is：
0 grade：Disease-free；
1 grade：Lesion area accounts for less than the 5% of full wafer leaf area；
3 grades：Lesion area accounts for the 6%-15% of full wafer leaf area；
5 grades：Lesion area accounts for the 16%-25% of full wafer leaf area；
7 grades：Lesion area accounts for the 26%-50% of full wafer leaf area；
9 grades：Lesion area accounts for the 50%-75% of full wafer leaf area；
11 grades：Lesion area accounts for more than the 75% of full wafer leaf area.
Disease index (%)=Σ (disease numbers of sheets * at different levels are with respect to value of series)/(investigation total number of sheets * 11) * 100
Prevention effect (%)=(check plot disease index-treatment region disease index)/check plot disease index * 100
By the linear regression analysis between the niqueMin of preventive effect and the logarithm value of series concentration, the EC50 of each medicament is obtained
Value, calculates the co-toxicity coefficient (CTC) of mixture, evaluates activity of the reagent agent to germ with this with the abundant method of Sun Yun.
The co-toxicity coefficient (CTC) >=120 of complex preparation shows as synergistic effect；Co-toxicity coefficient (CTC)≤80 shows as short of money
Anti- effect；80 ＜ co-toxicity coefficient (CTC) ＜ 120 show as summation action.
The Toxicity Determination of 1 benziothiazolinone of table and metrafenone to powdery mildew of cucumber
| Reagent agent | Proportioning | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| Benziothiazolinone (A) | -- | 0.65 | -- |
| Metrafenone (B) | -- | 2.89 | -- |
| A:B | 1：40 | 2.16 | 124.6 |
| A:B | 1：30 | 2.09 | 123.4 |
| A:B | 1：20 | 1.98 | 130.6 |
| A:B | 1：10 | 1.87 | 144.5 |
| A:B | 1：1 | 1.56 | 138.2 |
| A:B | 10：1 | 1.78 | 145.3 |
| A:B | 20：1 | 1.32 | 129.8 |
| A:B | 30：1 | 1.23 | 136.1 |
| A:B | 40：1 | 1.06 | 134.8 |
As shown in Table 1, benziothiazolinone and metrafenone mixed ratio are 1：40～40：When 1, CTC is all higher than 120, shows good
Good synergistic effect.
Preventive effect embodiment 2, the indoor harmacological effect of preventing and treating uncinula necator are determined
The preparation of grape powdery mildew spore suspension
Fresh grape powdery mildew spore is collected, and it is 2*10 concentration to be made into sterilized water5Individual/ml spore suspension, per
1000ml adds 7.8 grams of glucose, is inoculated with after 24 hours.
Experimental technique
Sent out using spore germination on slide, on slide, examination is supplied with what the sprinkling of small-sized laryngeal spray was prepared in advance
Liquid, to spray distilled water as control.After drying, the Fresh spores on sick leaf are gently adhered to spray liquid on slide
Simultaneously, then slide is placed on and is lined with the culture dish of two absorbent filters, each ware all drips equivalent sterilized water to be made to filter paper
Which fully absorbs water, and closes the lid, and is placed in 20 degree of incubators, makes filter paper be always maintained at moistening, and all process is all provided with 3 repetitions.
After 48 hours, microscopy is carried out under low power lens, the sprouting situation of 100 spores of recorded at random, the germ tube of all spores exceed spore
Diameter half is judged to spore germination, calculates germination rate and inhibiting rate.
Germination rate (%)=(sprouting spore count/microscopy spore sum) * 100%
Inhibiting rate (%)=[(control spore germination number-process spore germination number)/control spore germination number] * 100%
Table 2 respectively processes the inhibiting rate to grape powdery mildew spore
As shown in Table 2, benziothiazolinone and metrafenone mixed ratio are 1：40～40：When 1, prevent in the case that dosage is relatively low
Control effect and benziothiazolinone and metrafenone single dose is significantly better than that, show the effect of obvious compound synergic.
Preventive effect embodiment 3, field test prevents and treats uncinula necator
Test method
4 points are investigated in test on Liaoning Shenyang City wine-growing ground, per cell, and per is investigated 2 plants, is recorded with staging and is sent out
Course of disease degree, grade scale are as follows：
0 grade：Disease-free；
1 grade：Lesion area accounts for less than the 5% of full wafer leaf area；
3 grades：Lesion area accounts for the 6%-10% of full wafer leaf area；
5 grades：Lesion area accounts for the 11%-20% of full wafer leaf area；
7 grades：Lesion area accounts for the 21%-50% of full wafer leaf area；
9 grades：Lesion area accounts for more than the 50% of full wafer leaf area.
Control time and number of times
Test is investigated 4 times altogether, radix investigation before medicine, 14 days after first time medicine, is entered within 21 days after second medicine after 14 days and medicine
Row investigation.
Dispenser formulation and method
Inventive composition formulation is suspending agent, and application method is spraying.
Drug effect computational methods
Disease index=Σ (disease numbers of sheets * at different levels are with respect to value of series)/(investigation total number of sheets * 9) * 100
Prevention effect (%)=[1- (disease index after disease index * treatment region medicine before blank district medicine)/(blank right
According to disease index before disease index * treatment region medicine after area's medicine)] * 100
Table 3 respectively processes the effect of preventing and treating uncinula necator
As shown in Table 3, benziothiazolinone and metrafenone mixed ratio are 1：40～40：When 1, prevent in the case that dosage is relatively low
Control effect and benziothiazolinone and metrafenone single dose and comparison medicament is significantly better than that, show the effect of obvious compound synergic, Ke Yizuo
For replacement and the upgrading medication of 43% Haolike SC of common medicine of uncinula necator is prevented and treated, uncinula necator is prevented and treated.
Preventive effect embodiment 4, the Toxicity Determination of preventing and treating wheat powdery mildew
Experimental technique is referred to《People's Republic of China's agricultural industry criteria NY/T1156.11-2008 agricultural chemicals indoor biological is surveyed
Determine the 4th part of test rule bactericide：Preventing and treating wheat powdery mildew test pot-culture method》.First single dose and each Mixed Pharmacy are arranged 5
Individual variable concentrations.With the pure water added with a small amount of surfactant, wash and the Fresh spores covered with Powdery Mildew wheat leaf blade taken,
Filtered with double gauze, the suspension for making spore concentration for 1*105 spore/milliliter is standby.3 basins are often processed, are repeated for 4 times,
And set the process for not containing active ingredient containing only solvent and surfactant and make blank.With spore suspension in chemicals treatment
Front 24h inoculation, liquid is uniformly sprayed in blade face to all wettings, standby after liquid natural air drying.Inoculation and chemicals treatment
Potted plant wheat natural air drying afterwards, then moves to thermostatic chamber, cultivates 7-10 days under conditions of temperature 20-24 degree.It is blank right to treat
When reaching more than 80% according to sick leaf rate, classification investigation manages incidence everywhere, often processes at least 30 leaves of investigation, grade scale
For：
0 grade：Disease-free；
1 grade：Lesion area accounts for less than the 5% of full wafer leaf area；
3 grades：Lesion area accounts for the 6%-15% of full wafer leaf area；
5 grades：Lesion area accounts for the 16%-25% of full wafer leaf area；
7 grades：Lesion area accounts for the 26%-50% of full wafer leaf area；
9 grades：Lesion area accounts for the 50%-75% of full wafer leaf area；
11 grades：Lesion area accounts for more than the 75% of full wafer leaf area.
Disease index (%)=Σ (disease numbers of sheets * at different levels are with respect to value of series)/(investigation total number of sheets * 11) * 100
Prevention effect (%)=(check plot disease index-treatment region disease index)/check plot disease index * 100
By the linear regression analysis between the niqueMin of preventive effect and the logarithm value of series concentration, the EC50 of each medicament is obtained
Value, calculates the co-toxicity coefficient (CTC) of mixture, evaluates activity of the reagent agent to germ with this with the abundant method of Sun Yun.
The co-toxicity coefficient (CTC) >=120 of complex preparation shows as synergistic effect；Co-toxicity coefficient (CTC)≤80 shows as short of money
Anti- effect；80 ＜ co-toxicity coefficient (CTC) ＜ 120 show as summation action.
The Toxicity Determination of 4 benziothiazolinone of table and metrafenone to wheat powdery mildew
As shown in Table 4, benziothiazolinone and metrafenone mixed ratio are 1：40～40：When 1, CTC is all higher than 120, shows good
Good synergistic effect.
Preventive effect embodiment 5, prevent and treat the Toxicity Determination of apple mildew
Test method
The potato that the making of PDA culture medium will be removed the peel after cleaning is shredded, plus 1000 milliliters of water boil 0.5 hour, use yarn
Cloth filters off potato, adds water and complements to 1000 milliliters, then sugaring and agar-agar, and heating makes agar-agar melt completely, uses gauze while hot
Filter, be then divided in triangular flask, plus sterilize after tampon.Composition：200 grams of potato, 10-20 gram of glucose, agar-agar 10-20
Gram, 1000 milliliters of water.
Different agents are configured to the series concentration of 10 times of experimental concentration of desired concn respectively for the preparation of pastille culture medium
Liquid, with 1：9 ratio mixes the pastille culture medium for obtaining series concentration gradient with measure culture medium.
Assay method carries out Toxicity Determination using growth rate method to mycelial growth, screens the chemical drugs of high-efficiency low-toxicity
Agent.Test strains are seeded on PDA plate in 25 degree of lower cultures 3 days, bacterium colony are reached cake with 5 millimeters of card punch of internal diameter,
It is transplanted under sterile working on the PDA plate containing different agents, the contact culture medium of the one side with mycelia, is right with not adding medicine
According to (CK), 5 process are designed, each process is repeated 5 times, and cultivates 5 days under 25 degree of constant temperature, straight with crossing method measurement bacterium colony
Footpath, averages, and calculates inhibiting rate：Inhibiting rate=[(control colony diameter -5mm)-(processing colony diameter -5mm)]/(control
Colony diameter -5mm) * 100%.
The inhibition that 5 different agents of table are grown to apple mildew mycelia
As shown in Table 5, benziothiazolinone and metrafenone mixed ratio are 1：40～40：Inhibiting rate when 1, to apple mildew bacterium
Benziothiazolinone and metrafenone single dose is significantly better than that, shows the effect of obvious compound synergic.
Preventive effect embodiment 6, field test prevents and treats apple mildew
Test method
Test on Shaanxi Province Luochuan County apple cultivation ground, every cell investigates 4 points, and per is investigated 2 plants, and per plant is pressed east, western,
South, north, in 5 points sampling, record occurring degree with staging, grade scale is as follows：
0 grade：Disease-free spot；
1 grade：Lesion area accounts for less than the 10% of full wafer leaf area；
3 grades：Lesion area accounts for the 11%-25% of full wafer leaf area；
5 grades：Lesion area accounts for the 26%-40% of full wafer leaf area；
7 grades：Lesion area accounts for the 41%-65% of full wafer leaf area；
9 grades：Lesion area accounts for more than the 65% of full wafer leaf area.
Control time and number of times
Test is investigated 4 times altogether, radix investigation before medicine, 7 days after first time medicine, after second medicine 7 days after 7 days and third time medicine
Investigated.
Dispenser formulation and method
Inventive composition formulation is suspending agent, and application method is spraying.
Drug effect computational methods
Disease index=Σ (disease numbers of sheets * at different levels are with respect to value of series)/(investigation total number of sheets * 9) * 100
Prevention effect (%)=[1- (disease index after disease index * treatment region medicine before blank district medicine)/(blank right
According to disease index before disease index * treatment region medicine after area's medicine)] * 100
Table 6 respectively processes the prevention effect to apple mildew
As shown in Table 6, benziothiazolinone and metrafenone mixed ratio are 1：40～40：Inhibiting rate when 1, to apple mildew bacterium
Benziothiazolinone and metrafenone single dose and comparison medicament is significantly better than that, shows the effect of obvious compound synergic.Can be used as preventing and treating
25% Amici of common medicine of apple mildew reaches the replacement of suspending agent and upgrading medication,
Prevent and treat apple mildew.
Preventive effect embodiment 7, preventing and treating paddy rice powdery mildew field control effectiveness test
Test method is referred to《Pesticide field efficacy medicine test criterion (one) bactericidal agent for preventing and treating Cereal powdery mildew》Plot area
For 15-50 square metre, it is repeated 4 times.5 points of samplings are fixed per cell, look into 0.25 square metre of plant at per.Stage division：
0 grade：Disease-free；
1 grade：Lesion area accounts for less than the 5% of full wafer leaf area；
3 grades：Lesion area accounts for the 6%-10% of full wafer leaf area；
5 grades：Lesion area accounts for the 11%-20% of full wafer leaf area；
7 grades：Lesion area accounts for the 21%-50% of full wafer leaf area；
9 grades：Lesion area accounts for more than the 50% of full wafer leaf area.
Control time and number of times
Test is investigated 4 times altogether, radix investigation before medicine, 14 days after first time medicine, is entered within 21 days after second medicine after 14 days and medicine
Row investigation.
Dispenser formulation and method
Inventive composition formulation is suspending agent, and application method is spraying.
Drug effect computational methods
Disease index=Σ (disease numbers of sheets * at different levels are with respect to value of series)/(investigation total number of sheets * 9) * 100
Prevention effect (%)=[1- (disease index after disease index * treatment region medicine before blank district medicine)/(blank right
According to disease index before disease index * treatment region medicine after area's medicine)] * 100
Table 7 respectively processes the effect of preventing and treating paddy rice powdery mildew
As shown in Table 7, benziothiazolinone and metrafenone mixed ratio are 1：40～40：When 1, prevent in the case that dosage is relatively low
Control effect and benziothiazolinone and metrafenone single dose and comparison medicament is significantly better than that, show the effect of obvious compound synergic.Can make
25% Amici of common medicine for preventing and treating wheat powdery mildew reaches the replacement of suspending agent and upgrading medication, prevents and treats wheat powdery mildew.
Preventive effect embodiment 8, prevent and treat powdery mildew of cucumber field control effectiveness test
Test method is referred to《Pesticide field efficacy medicine test criterion (one) bactericidal agent for preventing and treating powdery mildew of cucumber》.Plot area is
15-50 square metre, it is repeated 4 times.Random 4 points of samplings per cell, per whole blades for investigating 2 plants, every leaf account for leaf by scab
The percentage classification record of area.
Stage division：
0 grade：Disease-free spot；
1 grade：Lesion area accounts for less than the 5% of full wafer leaf area；
3 grades：Lesion area accounts for the 6%-10% of full wafer leaf area；
5 grades：Lesion area accounts for the 11%-20% of full wafer leaf area；
7 grades：Lesion area accounts for the 21%-40% of full wafer leaf area；
9 grades：Lesion area accounts for more than the 40% of full wafer leaf area.
Control time and number of times
Test is investigated 3 times altogether, radix investigation before medicine, 7 days after first time medicine, after second medicine 14 after 7 days and second medicine
It is investigated.
Dispenser formulation and method
Inventive composition formulation is suspending agent, and application method is spraying.
Drug effect computational methods
Disease index=Σ (disease numbers of sheets * at different levels are with respect to value of series)/(investigation total number of sheets * 9) * 100
Prevention effect (%)=[1- (disease index after disease index * treatment region medicine before blank district medicine)/(blank right
According to disease index before disease index * treatment region medicine after area's medicine)] * 100
Table 8 respectively processes the effect for preventing and treating powdery mildew of cucumber
As shown in Table 8, benziothiazolinone and metrafenone mixed ratio are 1：40～40：When 1, prevent in the case that dosage is relatively low
Control effect and benziothiazolinone and metrafenone single dose and comparison medicament is significantly better than that, show the effect of obvious compound synergic.Can make
For replacement and the upgrading medication of the 80% sulphur water dispersible granules of common medicine of powdery mildew of cucumber is prevented and treated, wheat powdery mildew is prevented and treated.
Prepare 1 41% benziothiazolinone metrafenone missible oil of embodiment
Benziothiazolinone 1%, metrafenone 40%, ethanol 10%, calcium dodecyl benzene sulfonate 4%, AEO
5%, solvent naphtha supplies 100%.Through above-mentioned raw materials in agitator tank stirring and dissolving uniformly liquid obtains final product 41% benziothiazolinone benzene bacterium
Ketone missible oil.
Real preparation applies 2 31% benziothiazolinone metrafenone microemulsion of example
Benziothiazolinone 1%, metrafenone 30%, ethanol 10%, solvent naphtha 20%, calcium dodecyl benzene sulfonate 5%, poly alkyl alcohol
Oxygen vinethene 8%, water supplies 100%.By ethanol, solvent naphtha, benziothiazolinone, metrafenone, calcium dodecyl benzene sulfonate, poly alkyl alcohol
Oxygen vinethene stirring and dissolving uniformly oil phase, adds water under agitation, stirs into transparency liquid and obtain final product 31% benziothiazolinone metrafenone
Microemulsion.
Prepare 3 21% benziothiazolinone metrafenone aqueous emulsion of embodiment
Benziothiazolinone 1%, metrafenone 20%, isopropanol 10%, solvent naphtha 15%, calcium dodecyl benzene sulfonate 5%, alkyl phenol
APEO 8%, ethylene glycol 45, water supplies 100%.By isopropanol, solvent naphtha, benziothiazolinone, metrafenone, detergent alkylate sulphur
Sour calcium, APES, stirring and dissolving uniformly oil phase, water is added at 3000 turns per point telling under shearing, shearing 1 is little
When, ethylene glycol is eventually adding, is stirred and obtains final product 21% benziothiazolinone metrafenone aqueous emulsion.
Prepare 4 33% benziothiazolinone metrafenone suspending agent of embodiment
Benziothiazolinone 3%, metrafenone 30%, polycarboxylate 4%, ethylene glycol 4%, aluminium-magnesium silicate 0.5%, xanthans
0.15%, defoamer 0.5%, water supplies 100%.By polycarboxylate, ethylene glycol, aluminium-magnesium silicate, xanthans, defoamer, water, warp
High speed shear is mixed, and sequentially adds benziothiazolinone, metrafenone, sand milling 2-3 hour in sand mill, make particle diameter 5 microns with
Under, 33% benziothiazolinone metrafenone suspending agent.
Prepare 5 30% benziothiazolinone metrafenone of embodiment and dispersible oil-suspending agent
Benziothiazolinone 15%, metrafenone 15%, calcium dodecyl benzene sulfonate 5%, APES 8%, magnesium silicate
Aluminium 2%, methyl oleate supplies 100%.By calcium dodecyl benzene sulfonate, APES, aluminium-magnesium silicate, methyl oleate
Mix through high speed shear, sequentially add benziothiazolinone, metrafenone, sand milling 2-3 hour in sand mill, particle diameter is made at 5 microns
Hereinafter, 30% benziothiazolinone metrafenone dispersibles oil-suspending agent.
Prepare 6 22% benziothiazolinone metrafenone wettable powder of embodiment
Benziothiazolinone 20%, metrafenone 2%, lauryl sodium sulfate 3%, calcium lignosulfonate 4%, naphthalene sulfonate 5%, in vain
Carbon black 3%, kaolin supplies 100%.Above-mentioned material is mixed in mixer, in mixing after crushing through airslide disintegrating mill
Mix in machine, that is, 22% benziothiazolinone metrafenone wettable powder is obtained.
Prepare 7 42% benziothiazolinone metrafenone water dispersible granules of embodiment
Benziothiazolinone 40%, metrafenone 2%, lauryl sodium sulfate 4%, carboxylate 6%, ammonium sulfate 10%, cornstarch
10%, precipitated calcium carbonate supplies 100%.Above-mentioned material is mixed in mixer, is mixed after airslide disintegrating mill,
Be subsequently adding fluidized bed pelletizer or add water kneading after extruder grain, drying, sample analysis after screening, obtain final product 42% benziothiazolinone
Metrafenone water dispersible granules.
Prepare 8 33% benziothiazolinone metrafenone suspension seed-coating agent of embodiment
Benziothiazolinone 3%, metrafenone 30%, naphthalene sulfonate 4%, propane diols 3%, aluminium-magnesium silicate 0.3%, xanthans
0.15%, polyethylene glycol 3%, rose violet 2%, defoamer 0.5%, water supplies 100%.By naphthalene sulfonate, propane diols, magnesium silicate
Aluminium, xanthans, polyethylene glycol, rose violet, defoamer, water, mix through high speed shear, sequentially add benziothiazolinone, metrafenone,
Sand milling 2-3 hour in sand mill, makes particle diameter below 5 microns, 33% benziothiazolinone metrafenone suspension seed-coating agent.
Prepare 9 32% benziothiazolinone metrafenone water and milk seed coat agent of embodiment
Benziothiazolinone 2%, metrafenone 30%, isopropanol 10%, solvent naphtha 20%, calcium dodecyl benzene sulfonate 5%, alkyl phenol
APEO 6%, ethylene glycol 4%, polyvinyl alcohol 1%, rose-red water supply 100%.By isopropanol, solvent naphtha, benziothiazolinone,
Metrafenone, calcium dodecyl benzene sulfonate, APES, stirring and dissolving uniformly oil phase, at 3000 turns per point telling
Shearing is lower to add water, rose-red and polyvinyl alcohol, shears 1 hour, is eventually adding ethylene glycol, stirs and obtain final product 32% benziothiazolinone
Metrafenone water and milk seed coat agent.
Prepare 10 62% benziothiazolinone metrafenone Seed Treatment of embodiment and dispersible pulvis
Benziothiazolinone 60%, metrafenone 2%, pull open powder 3%, calcium lignosulfonate 4%, carboxylate 5%, white carbon 2%, gathers
Ethylene glycol 5%, pinkish red 4%, kaolin supplies 100%.Above-mentioned material is mixed in mixer, through airslide disintegrating mill powder
Mix in mixer after broken, that is, 62% benziothiazolinone metrafenone Seed Treatment is obtained and dispersibles pulvis.
Prepare 11 77% benziothiazolinone metrafenone Seed Treatment of embodiment and dispersible granula
Benziothiazolinone 70%, metrafenone 7%, dodecyl sodium sulfate 3%, carboxylate 4%, sodium sulphate 5%, cornstarch
5%, polyvinyl alcohol 0.5%, 1% precipitated calcium carbonate of rose-red supply 100%.Above-mentioned material is mixed in mixer,
Mix after airslide disintegrating mill, be subsequently adding fluidized bed pelletizer or add water kneading after extruder grain, drying, after screening
Sample analysis, obtain final product 77% benziothiazolinone metrafenone Seed Treatment and dispersible granula.
Claims (4)
1. a kind of bactericidal composition containing benziothiazolinone Yu metrafenone, it is characterised in that：The active ingredient of the bactericidal composition is
Benziothiazolinone and metrafenone, wherein active ingredient benziothiazolinone and mass ratio be 1：40-40：1.
2. a kind of bactericidal composition containing benziothiazolinone Yu metrafenone according to claim 1, it is characterised in that：Effectively become
Point gross mass accounts for the 1%-80% of whole preparation gross mass, and remaining is auxiliary element.
3. a kind of bactericidal composition containing benziothiazolinone Yu metrafenone according to claim 1, it is characterised in that：This kills
Bacteria composition can be processed into missible oil, microemulsion, aqueous emulsion, suspending agent, dispersible oil-suspending agent, wettable powder, moisture dissipate
Granula, suspension seed-coating agent, water and milk seed coat agent, Seed Treatment dispersible pulvis, Seed Treatment and dispersible granula.
4. the composition according to claim 1,2 or 3 is used for preventing and treating wheat, paddy rice, cucumber, grape, apple mildew, or
Person is used for preparing preventing and treating wheat, paddy rice, cucumber, grape, the agricultural chemicals of apple mildew.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107821404A (en) * | 2017-10-18 | 2018-03-23 | 陕西西大华特科技实业有限公司 | A kind of bactericidal composition and its application containing benziothiazolinone and fluorine thiazole pyrrole ethyl ketone |
| CN110476987A (en) * | 2019-08-28 | 2019-11-22 | 浙江海正化工股份有限公司 | Bactericidal pesticide composition and its preparation method and application containing copper 8-hydroxyquinolinate and metrafenone |
| CN115067346A (en) * | 2022-04-28 | 2022-09-20 | 湖南农业大学 | Seed coating agent for preventing and treating watermelon fruit blotch and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107821404A (en) * | 2017-10-18 | 2018-03-23 | 陕西西大华特科技实业有限公司 | A kind of bactericidal composition and its application containing benziothiazolinone and fluorine thiazole pyrrole ethyl ketone |
| CN110476987A (en) * | 2019-08-28 | 2019-11-22 | 浙江海正化工股份有限公司 | Bactericidal pesticide composition and its preparation method and application containing copper 8-hydroxyquinolinate and metrafenone |
| CN115067346A (en) * | 2022-04-28 | 2022-09-20 | 湖南农业大学 | Seed coating agent for preventing and treating watermelon fruit blotch and preparation method thereof |
| CN115067346B (en) * | 2022-04-28 | 2024-03-01 | 湖南农业大学 | Seed coating agent for preventing and treating watermelon fruit blotch and preparation method thereof |
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Application publication date: 20170308 |