CN106461656B - 用于检测样品中的目标成分的生物传感器 - Google Patents

用于检测样品中的目标成分的生物传感器 Download PDF

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Publication number
CN106461656B
CN106461656B CN201580034190.1A CN201580034190A CN106461656B CN 106461656 B CN106461656 B CN 106461656B CN 201580034190 A CN201580034190 A CN 201580034190A CN 106461656 B CN106461656 B CN 106461656B
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purification
chamber
particles
detection
magnetic
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Chinese (zh)
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CN106461656A (zh
Inventor
A.H.J.伊明克
J.H.尼伊尤文休斯
G.萨巴特
W.M.哈德曼
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Siemens Medical Systems Holland Ltd
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Koninklijke Philips NV
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
CN201580034190.1A 2014-06-25 2015-06-24 用于检测样品中的目标成分的生物传感器 Active CN106461656B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14173795.7 2014-06-25
EP14173795 2014-06-25
PCT/EP2015/064188 WO2015197659A1 (en) 2014-06-25 2015-06-24 Biosensor for the detection of target components in a sample

Publications (2)

Publication Number Publication Date
CN106461656A CN106461656A (zh) 2017-02-22
CN106461656B true CN106461656B (zh) 2020-03-24

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US (1) US10307759B2 (https=)
EP (1) EP3161485B1 (https=)
JP (1) JP6639424B2 (https=)
CN (1) CN106461656B (https=)
WO (1) WO2015197659A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11435371B2 (en) 2016-11-24 2022-09-06 Siemens Healthineers Nederland B.V. Device, system method and kit for isolating an analyte from a body fluid sample
US20210069701A1 (en) * 2019-09-10 2021-03-11 Bgi Shenzhen Co., Ltd. Operation of magnetic beads on microfluidics substrates

Citations (3)

* Cited by examiner, † Cited by third party
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CN101477081A (zh) * 2008-03-07 2009-07-08 重庆大学 基于磁珠固定的微加工、表面修饰方法及微芯片结构
CN102047117A (zh) * 2008-05-27 2011-05-04 皇家飞利浦电子股份有限公司 用于检测唾液中分析物的设备和方法
CN102083533A (zh) * 2008-04-10 2011-06-01 芬兰技术研究中心 微流控芯片装置及其使用

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US6623945B1 (en) * 1999-09-16 2003-09-23 Motorola, Inc. System and method for microwave cell lysing of small samples
US7763453B2 (en) * 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
CA2685031A1 (en) 2007-03-19 2008-09-25 Atm Metabolics Lllp Composition for treating diabetes and metabolic disorders with quercetin, myrcetin and chlorogenic acid
EP2072133A1 (en) 2007-12-20 2009-06-24 Koninklijke Philips Electronics N.V. Multi-compartment device with magnetic particles
US8187808B2 (en) 2008-02-29 2012-05-29 Northwestern University Barriers for facilitating biological reactions
EP2108938A1 (en) 2008-04-09 2009-10-14 Koninklijke Philips Electronics N.V. A carrier for optical detection in small sample volumes
JP5311518B2 (ja) 2008-10-06 2013-10-09 コーニンクレッカ フィリップス エヌ ヴェ マイクロ流体装置
WO2010070461A1 (en) 2008-12-16 2010-06-24 Koninklijke Philips Electronics N. V. Hydrophobic valve
US9874294B2 (en) 2009-06-03 2018-01-23 Koninklijke Philips N.V. Valve with material having modifiable degree of penetrability
WO2010143295A1 (ja) * 2009-06-12 2010-12-16 株式会社島津製作所 多段型遺伝子増幅方法
EP2454020B1 (en) 2009-07-17 2019-05-15 Koninklijke Philips N.V. Apparatus and method for the enrichment of magnetic particles
CN102549445B (zh) 2009-09-28 2015-04-08 皇家飞利浦电子股份有限公司 用于单个颗粒检测的生物传感器系统
US9387484B2 (en) 2009-10-06 2016-07-12 Koninklijke Philips N.V. Magnetic sample purification
EP2369343B1 (de) 2010-03-15 2012-01-18 Boehringer Ingelheim International Gmbh Vorrichtung und Verfahren zur Manipulation oder Untersuchung einer flüssigen Probe
WO2013169709A1 (en) 2012-05-08 2013-11-14 Northwestern University Cartridge for use in an automated system for isolating an analyte from a sample, and methods of use
CN104395751B (zh) * 2012-06-29 2016-10-19 皇家飞利浦有限公司 含有干扰颗粒的流体的处理

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CN101477081A (zh) * 2008-03-07 2009-07-08 重庆大学 基于磁珠固定的微加工、表面修饰方法及微芯片结构
CN102083533A (zh) * 2008-04-10 2011-06-01 芬兰技术研究中心 微流控芯片装置及其使用
CN102047117A (zh) * 2008-05-27 2011-05-04 皇家飞利浦电子股份有限公司 用于检测唾液中分析物的设备和方法

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Also Published As

Publication number Publication date
WO2015197659A1 (en) 2015-12-30
CN106461656A (zh) 2017-02-22
JP6639424B2 (ja) 2020-02-05
JP2017524921A (ja) 2017-08-31
EP3161485B1 (en) 2018-10-31
US20170113223A1 (en) 2017-04-27
US10307759B2 (en) 2019-06-04
EP3161485A1 (en) 2017-05-03

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Patentee before: Royal Philips Co.,Ltd.