CN106461493A

CN106461493A - Pressure indicator for an oscillating positive expiratory pressure device

Info

Publication number: CN106461493A
Application number: CN201580018758.0A
Authority: CN
Inventors: N.阿利佐蒂; C.多布森; J.施米德特
Original assignee: TRUDEL MEDICAL Ltd
Current assignee: TRUDEL MEDICAL Ltd; Trudell Medical International
Priority date: 2014-02-07
Filing date: 2015-02-09
Publication date: 2017-02-22
Anticipated expiration: 2035-02-09
Also published as: EP3102918A4; AU2015213537B2; US20220031982A1; CN106461493B; WO2015118482A1; EP3102918B1; US10363383B2; US20190275272A1; CA2937286C; JP2017512079A; JP6648025B2; EP3102918A1; ES2768927T3; MX2016010243A; PT3102918T; AU2015213537A1; US11116923B2; US11813398B2; US20240108832A1; CA2937286A1

Abstract

A pressure indicator for a respiratory treatment device, the pressure indicator including an instrument for measuring pressures, a conduit configured to transmit a pressure within the respiratory treatment device to the instrument, and a pressure stabilizer orifice positioned within the conduit.

Description

Pressure indicator for oscillatory type PEP device

Related application

This application claims the U.S. Provisional Application No.61/937 in the examination submitted to on 2 7th, 2014,433 rights and interests, this faces When apply for whole be incorporated herein by reference.

Technical field

The present invention relates to for the pressure indicator of respiratory therapy apparatus, and in particular it relates to exhale for oscillatory type Malleation（" oscillating positive expiratory pressure, OPEP "）Device.

Background technology

The mankind can produce 30 milliliters of expectorant daily upwards, and expectorant is a class bronchial secretion.Normally, effectively cough be enough to It is simultaneously removed from the respiratory tract of body by lax secretions.But, for more serious bronchial obstruction（Such as subside Respiratory tract）People for, single cough may be not enough to remove block.

OPEP therapy represents the effective bronchus health technology for removing the bronchial secretion in human body, and is to deposit Patient in bronchial obstruction（Such as suffer from the patient of chronic obstructive pulmonary disease）Treatment and continuing care importance.Phase Vibration back pressure is sent to pulmonary by the vibration of the pressure venting one's pent-up feelings at letter, OPEP therapy or period mouth of feeling elated and exultant effectively, by This respiratory tract separately blocking the lax secretions increasing bronchial obstruction.

OPEP therapy is a kind of attractive form of therapy, because it easily can be taught Most patients, and This kind of patient plant can the responsibility that undertake administration OPEP therapy in the whole while in hospital and at home.For this reason, having been developed over being permitted How portable OPEP.

There is provided the visually indicating of pressure realized during OPEP therapy can assist user to the user of this kind of device And his or her clinician applies OPEP therapy in comfortable or preferred pressure limit, thus improve therapeutic outcome and shorten Total treatment length.The portable pressure indicator that with this OPEP device be used together is disclosed herein.

Content of the invention

A kind of pressure indicator for respiratory therapy apparatus includes：Instruments for pressure measurement；Conduit, described conduit It is configured to for the pressure in described respiratory therapy apparatus to be sent to described instrument；And the pressure stability being located in described conduit Aperture.Described respiratory therapy apparatus can be oscillatory type PEP device.Described instrument can be piezometer.

On the other hand, described instrument can have the passage connecting with described catheter fluid.The part of described conduit can be prolonged Reach in passage.Pressure stability aperture can be located in passage.Pressure stability aperture can be configured to damping from described respiratory therapy Device is sent to the vibration of the pressure of described instrument.

On the other hand, described pressure stability aperture can have in 0.196mm²And 1.767mm²Between area of section.Institute State pressure stability aperture can have in 0.283mm²And 0.636mm²Between area of section.Along the whole length of described conduit, institute The area of section stating pressure stability aperture is smaller than the area of section of described conduit.The part of described conduit may extend into described instrument In device, or the part that the passage connecting with described catheter fluid in described instrument can be formed.Described pressure stability aperture can Described partly interior in described instrument positioned at extending to of described conduit, or can be formed in described instrument with described conduit stream The part of the passage of body connection.Pressure stability aperture can be configured to damping and is sent to described instrument from described respiratory therapy apparatus The vibration of the pressure of device.

On the other hand, described instrument may include the use for being described respiratory therapy apparatus during or after treatment Person provides vision or the indicator of auditory feedback.

On the other hand, described pressure indicator can be permanently or removably attached to blowing of described respiratory therapy apparatus Mouthful.Described pressure indicator can be in the sky of the entrance substantially not blocked from the user of described respiratory therapy apparatus to described conduit The position of air-flow is connected to described respiratory therapy apparatus.

On the other hand, described piezometer may include piston-type measurement device.Alternatively, described piezometer may include rotating disk Formula quantifier.

On the other hand, described instrument can make the user of described respiratory therapy apparatus during treating it can be seen that The position of described indicator is permanently or removably attached to described respiratory therapy apparatus.

On the other hand, a kind of method of offer visual feedback during applying oscillatory type PEP therapy includes：? The porch of the conduit being connected with oscillatory type PEP device receives discharge air stream；By limiting by described conduit The discharge air stream in described pressure stability aperture, damps the vibration of the pressure of discharge air in described conduit；In described conduit Exit measurement pressure；And the instruction of the pressure in the measurement of the exit of described conduit is provided.

On the other hand, piezometer measures pressure in the exit of conduit.Piezometer be may include and connected with catheter fluid Passage.The part of conduit may extend in passage.Pressure stability aperture can be located in passage.

On the other hand, described pressure stability aperture can have in 0.196mm²And 1.767mm²Between area of section.Institute State pressure stability aperture can have in 0.283mm²And 0.636mm²Between area of section.Along the whole length of described conduit, institute The area of section stating pressure stability aperture is smaller than the area of section of described conduit.The part of described conduit may extend into piezometer In.It is described partly interior in piezometer that described pressure stability aperture can be located at extending to of described conduit.

On the other hand, described instruction may include audition or visual feedback.

On the other hand, described conduit may be connected to the mouthpiece of oscillatory type PEP device.Conduit can not hinder substantially The position of the air stream of the entrance from the user of described oscillatory type PEP device to described conduit for the plug shakes described in being connected to Swing formula PEP device.

On the other hand, piezometer may include piston-type measurement device.Alternatively, piezometer may include rotating disc type metering Device.

Conduit can be seen that described piezometer in the user making described oscillatory type PEP device during treating Position be connected to oscillatory type PEP device.

On the other hand, a kind of pressure indicator for respiratory therapy apparatus includes：Instruments for pressure measurement, institute State instrument include chamber, be configured to receive from described respiratory therapy apparatus the chamber entrance of air stream and with described breathing The chamber blow vent of the atmosphere around therapy equipment.Pressure stability aperture is located at described chamber entrance or described chamber blow vent At least one of in.The area of section in described pressure stability aperture less than described pressure stability aperture be located therein described in enter Mouth or the area of section of blow vent.Described instrument is piezometer.

On the other hand, described pressure indicator includes the film in described chamber.It is described that described film is configured to division Chamber, thus stop that the air stream flowing through described chamber entrance from described respiratory therapy apparatus passes through described chamber blow vent.

On the other hand, described chamber blow vent may include multiple openings.Described pressure stability aperture may include positioned at described Multiple apertures in opening.

On the other hand, described pressure stability aperture can have in 0.196mm²And 1.767mm²Between area of section.Institute State pressure stability aperture can have in 0.283mm²And 0.636mm²Between area of section.

Brief description

Fig. 1 is the front perspective view of OPEP device；

Fig. 2 is the rear perspective view of the OPEP device of Fig. 1；

Fig. 3 is the cross-sectional perspective view intercepting along the line III of OPEP device in FIG, the internal part of not shown OPEP device；

Fig. 4 is the exploded view of the OPEP device of Fig. 1, illustrates the internal part of OPEP device；

Fig. 5 is the cross-sectional perspective view intercepting along the line III of OPEP device in FIG, illustrates the internal part of OPEP device；

Fig. 6 is the different cross section axonometric chart intercepting along the line VI of OPEP device in FIG, illustrates the internal part of OPEP device；

Fig. 7 is the different cross section axonometric chart intercepting along the line VII of OPEP device in FIG, illustrates the internal part of OPEP device；

Fig. 8 is the front perspective view of the limiter component being operatively connectable to blade；

Fig. 9 is and the rear perspective view of limiter component that is connected of the ground of the vane operation shown in Fig. 8；

Figure 10 is and the front view of limiter component that is connected of the ground of the vane operation shown in Fig. 8；

Figure 11 is and the top view of limiter component that is connected of the ground of the vane operation shown in Fig. 8；

Figure 12 is the front perspective view being illustrated the variable-nozzle that discharge air stream does not flow through wherein；

Figure 13 is the rear perspective view of the variable-nozzle being illustrated Figure 12 that discharge air stream does not flow through wherein；

Figure 14 is the front perspective view being shown with the variable-nozzle of Figure 12 that high flow rate discharge air stream flows through wherein；

Figure 15 A-C is the top perspective view of the OPEP device of Fig. 1, illustrates the graphical representation of exemplary of the operation of OPEP device of Fig. 1；

Figure 16 is to be illustrated not spue the front perspective view of the different embodiments of variable-nozzle that air stream flows through wherein；

Figure 17 is to be illustrated not spue the rear perspective view of the variable-nozzle of Figure 16 that air stream flows through wherein；

Figure 18 is the front perspective view of the second embodiment of OPEP device；

Figure 19 is the rear perspective view of the OPEP device of Figure 18；

Figure 20 is the exploded view of the OPEP device of Figure 18, shows the internal part of OPEP device；

Figure 21 is the sectional view of the line I intercepting of the OPEP device along along Figure 18, shows the internal part of OPEP device；

Figure 22 is the sectional view of the line II intercepting of the OPEP device along along Figure 18, shows the internal part of OPEP device；

Figure 23 is the sectional view of the line III intercepting of the OPEP device along along Figure 18, shows the internal part of OPEP device；

Figure 24 is the front perspective view of the governor motion of OPEP device of Figure 18；

Figure 25 is the rear perspective view of the governor motion of Figure 24；

Figure 26 is to stand with the forward sight of the limiter component for being connected to vane operation used in the OPEP device of Figure 18 Body figure；

Figure 27 is the front perspective view of the governor motion of Figure 24 together with limiter component and blade assembling with Figure 26；

Figure 28 is the partial section of the assembly of the Figure 27 in the OPEP device of Figure 18；

Figure 29 A-B is partial section it is illustrated that the setting of the assembly of Figure 27 in the OPEP device of Figure 18；

Figure 30 is the front view of the OPEP device of Figure 18 it is illustrated that the controllability aspect of OPEP device；

Figure 31 is the partial section of the assembly of the Figure 27 in the OPEP device of Figure 18；

Figure 32 A-B is the partial section that intercepts of line III of the OPEP device along along Figure 18 it is illustrated that the possible configuration of OPEP device；

Figure 33 A-B is top perspective view it is illustrated that the controllability of the OPEP device of Figure 18；

Figure 34 A-B is the top perspective view of the OPEP device of Figure 18 it is illustrated that the controllability of OPEP device；

Figure 35 is the front perspective view of another embodiment of OPEP device；

Figure 36 is the rear perspective view of the OPEP device of Figure 35；

Figure 37 is the axonometric chart of the bottom of OPEP device of Figure 35；

Figure 38 is the exploded view of the OPEP device of Figure 35；

Figure 39 is the sectional view intercepting along the line I in Figure 35, the internal part of not shown OPEP device；

Figure 40 is the sectional view intercepting along the line I in Figure 35, shows the internal part of OPEP device；

Figure 41 is the front perspective view of the inner box of OPEP device of Figure 35；

Figure 42 is the sectional view of the inner box intercepting along the line I in Figure 41；

Figure 43 is the axonometric chart of the blade of OPEP device of Figure 35；

Figure 44 is the front perspective view of the limiter component of the OPEP device of Figure 35；

Figure 45 is the rear perspective view of the limiter component of Figure 44；

Figure 46 is the front view of the limiter component of Figure 44；

Figure 47 is the front perspective view of the governor motion of OPEP device of Figure 35；

Figure 48 is the rear perspective view of the governor motion of Figure 47；

Before Figure 49 is the governor motion of Figure 47-48 together with limiter component with Figure 44-46 and the blade assembling of Figure 43 Parallax stereogram；

Figure 50 is the front perspective view of the variable-nozzle of OPEP device of Figure 35；

Figure 51 is the rear perspective view of the variable-nozzle of Figure 50；

Figure 52 is the front perspective view of the check valve of OPEP device of Figure 35；

Figure 53 is the axonometric chart of the first embodiment of the pressure indicator for OPEP device；

Figure 54 is the axonometric chart of the pressure indicator of the Figure 53 being connected with the OPEP device of Figure 35；

Figure 55 A-B is side-looking and the sectional view of the pressure indicator of Figure 53；

Figure 56 A-E is top view and the sectional view of the pressure indicator of Figure 53；

Figure 56 F-G is various side views, perspective view and the sectional view of the alternate embodiment of the pressure indicator of Figure 53；

Figure 56 H-56I provides the pressure oscillation observing the pressure indicator of the Figure 53 being used without pressure stability aperture and tool The diagram that the pressure indicator having the Figure 53 in pressure stability aperture compares；

Figure 57 is the axonometric chart of the second embodiment of the pressure indicator for OPEP device；

Figure 58 is the axonometric chart of the pressure indicator of the Figure 57 being connected with the OPEP device of Figure 35；

Figure 59 A-C is side view, top view and the sectional view of the pressure indicator of Figure 57；

Figure 59 D-59E provides the pressure oscillation observing the pressure indicator of the Figure 57 being used without pressure stability aperture and tool The diagram that the pressure indicator having the Figure 57 in pressure stability aperture compares；

Figure 60 is the axonometric chart of the 3rd embodiment of the pressure indicator being connected with the OPEP device of Figure 35；

Figure 61 is the sectional view of the pressure indicator of the Figure 60 being connected with the OPEP device of Figure 35；

Figure 62 is the side view of the fourth embodiment of the pressure indicator being connected with the OPEP device of Figure 35；

Figure 63 A-B is side-looking and the sectional view of the pressure indicator of Figure 62；

Figure 64 A-B is equipped with the manometric diagram in pressure stability aperture；

Figure 65 A-B is equipped with another manometric diagram in pressure stability aperture；

Figure 66-67 be the Figure 53 being connected with commercially available OPEP device and 57 pressure indicator axonometric chart；

Figure 68-69 be the Figure 53 being connected with another commercially available OPEP device and 57 pressure indicator axonometric chart；

Figure 70-71 be the Figure 53 being connected with another commercially available OPEP device and 57 pressure indicator axonometric chart；

Figure 72 is the axonometric chart of the alternate embodiment of pressure indicator, not shown piezometer, and it includes stoping unplanned setting Put and by using the feature being limited to approved respiratory therapy apparatus；

Figure 73 be unplanned be arranged on the OPEP device of Figure 35 during Figure 72 pressure indicator different axonometric charts, It is shown having piezometer；

Figure 74 is to be arranged on approved respiratory therapy apparatus（It is the OPEP device of Figure 35 in this case）Figure 72 after upper Pressure indicator side view, it is shown having piezometer.

Specific embodiment

OPEP therapy is effective in operating condition.For example, the flow velocity venting one's pent-up feelings that adult can have is every at 10 to 60 liters In the range of minute, and it is positively retained at 8 to 18cmH₂Static state in the range of O pressure venting one's pent-up feelings.In these parameters, when pressure venting one's pent-up feelings The change of power（That is, amplitude）In 5 to 20cmH₂During in the range of O and with the hunting of frequency of 10 to 40Hz, OPEP therapy is believed It is maximally effective.On the contrary, teenager is likely to be of much lower flow velocity venting one's pent-up feelings, and can keep lower static state pressure venting one's pent-up feelings, Thus change the operating condition of maximally effective administration OPEP therapy.Equally, for the people with respiratory disorder, or on the contrary, for The athlete of health, ideal operating conditions may differ from the ideal operating conditions of average adult human.As described below, disclosed The part of OPEP device is optional and/or adjustable so that can confirm that and keeping preferable operating condition（For example, vibrate The amplitude of pressure and frequency）.Each in various embodiments described herein obtains the frequency in above-listed expected range and shakes Width scope.Each in various embodiments described herein is also configured to realization and falls in above-listed extraneous frequency and shake Width.

First OPEP embodiment

With reference first to Fig. 1-4, show the front perspective view of OPEP device 100, rear perspective view, cross-sectional front axonometric chart and point Xie Tu.In order to illustrate, eliminate the internal part of OPEP device 100 in Fig. 3.OPEP device 100 generally includes housing 102, chamber Entrance 104, first chamber outlet the 106, second chamber outlet 108（Most preferably visible in Fig. 2 and 7）And with chamber entrance 104 fluid even Logical mouthpiece 109.Although illustrate that mouthpiece 109 is integrally formed with housing 102 in figures 1-4, it is contemplated that mouthpiece 109 can be Removable and the mouthpiece 109 in order to keep different size required for ideal operating conditions or shape can be replaced by.One As, housing 102 and mouthpiece 109 can be made up of any durable material, such as polymer.A kind of such material is polypropylene. Alternatively, acrylonitrile-butadiene-styrene (ABS) can be used（ABS）.

Alternatively, other or extra interface, such as air tube or gas mask（Not shown）, can fluid flow communication attached It is connected to mouthpiece 109 and/or be connected with housing 102.For example, housing 102 may include be in fluid communication with mouthpiece 109 have individually One-way sucting valve（Not shown）Suction port（Not shown）, sucked by check valve with the user allowing OPEP device 100 Around air and transit chamber entrance 104 feel elated and exultant, without exiting OPEP device 100 between air-breathing and cycle venting one's pent-up feelings Mouthpiece 109.Additionally, any amount of aerosol delivery device may be connected to OPEP device 100, for example, by above-mentioned Suction port, to apply aerosol and OPEP therapy simultaneously.So, suction port may include, for instance, it is possible to accommodate user Plan the mouthpiece of specific aerosol delivery device that is used together with OPEP device 100 or the elastomer adapter of outlet or other Flexible adapter.As used herein, term aerosol delivery device is understood to include but is not limited to, for example, any Aerosol apparatus, soft mist inhaler（soft mist inhaler）, pressurized metered dose inhalers (pressurized metered dose Inhaler, pMDI), Diskuses（Dry powder inhaler, DPI）, holding chamber（holding chamber） Combination with pressurized metered dose inhalers or similar device.Suitably commercially available aerosol delivery device includes but is not limited to AEROECLIPSE aerosol apparatus, RESPIMAT soft mist inhaler, LC Sprint aerosol apparatus, AEROCHAMBER PLUS air pressure keep Device, MICRO MIST aerosol apparatus, SIDESTREAM aerosol apparatus, Inspiration Elite aerosol apparatus, FLOVENT pMDI, VENTOLIN pMDI, AZMACORT pMDI, BECLOVENT pMDI, QVAR pMDI and AEROBID PMDI, XOPENEX PMDI, PROAIR pMDI, PROVENT pMDI, SYMBICORT pMDI, TURBOHALER DPI and DISKHALER DPI.? U.S. Patent application No.4,566,452；No.5,012,803；No.5,012,804；No.5,312,046；No.5,497,944； No.5,622,162；No.5,823,179；No.6,293,279；No.6,435,177；No.6,484,717；No.6,848, 443；No.7,360,537；Can find in No.7,568,480 and No.7,905,228 suitable aerosol delivery device is retouched State, the whole of these applications are incorporated herein by reference.

In figures 1-4, housing 102 generally box-like.But, the housing 102 of any shape can be used.Additionally, chamber entrance 104th, the first chamber outlet 106 and the second chamber outlet 108 can have any shape or a series of shape, such as multiple（That is, more than one Individual）Circular channel or linear slot.More importantly it is to be understood that chamber entrance 104, the first chamber outlet 106 and the second chamber export 108 area of section is only several in the factor affect above-mentioned ideal operating conditions.

Preferably, housing 102 is openable, thus the part being included in can be according to holding ideal operating conditions Need periodically close, clean, change or reconfigure.So, Fig. 1-4 illustrate housing 102 include forward section 101, in Between section 103 and rear portion section 105.Can by any suitable means, fasten, pressing etc., by forward section 101, Intermediate section 103 and rear portion section 105 are detachably connected to each other, thus being formed enough to allow OPEP between related section Device 100 suitably applies the sealing of OPEP therapy.

As shown in figure 3, the first chamber outlet 106 and the outlet of the second chamber are limited at by the flow path venting one's pent-up feelings 110 that dotted line is pointed out Between at least one of 108 and mouthpiece 109（Most preferably visible in the figure 7）.More specifically, flow path 110 of feeling elated and exultant starts from blowing Mouth 109, through chamber entrance 104, and enters the first chamber 114 or entrance cavity.In the first chamber 114, flow path 180 degree venting one's pent-up feelings turns Curved, through chamber passage 116, and enter the second chamber 118 or outlet plenum.In the second chamber 118, flow path 110 venting one's pent-up feelings can be by the OPEP device 100 is left at least one of one chamber outlet 106 and the second chamber outlet 108.In this way, flow path 110 venting one's pent-up feelings It is " folded " on itself, i.e. it makes longitudinal direction in one of the first chamber outlet 106 and the second chamber outlet 108 and chamber In opposite direction between entrance 104.But, it will be apparent to one skilled in the art that the flow path venting one's pent-up feelings 110 pointed out by dotted line is example Property, and the air felt elated and exultant in OPEP device 100 passes through the first chamber outlet 106 at it from mouthpiece 109 or chamber entrance 104 Or can be along any amount of direction or path flowing during the second chamber outlet 108.

Fig. 3 also illustrates that various other features of the OPEP device 100 being connected with housing 102.For example, retainer 122 stops Limiter component 130 described below（See Fig. 5）Direction along mistake is opened；It is formed as accommodating the seat of limiter component 130 124 form around chamber entrance 104；And, upper bearing (metal) 126 and lower bearing 128 are formed in housing 102 and are configured to accommodate It is rotatably installed in axle therebetween.One or more guiding walls 120 are located in the second chamber 118, in order to along flow path of feeling elated and exultant The air that 110 guiding spue.

Turn to Fig. 5-7, the various cross-sectional perspective view of OPEP device 100 and its internal part are shown.OPEP device 100 interior Portion's part includes limiter component 130, blade 132 and optional variable-nozzle 136.As illustrated, limiter component 130 and leaf Piece 132 relies on the axle 134 being rotatably installed between upper bearing (metal) 126 and lower bearing 128 to be operatively connected together, and makes Obtain limiter component 130 and blade 132 can rotate in unison about axle 134.As described in more detail below, variable-nozzle 136 include being configured in response to the discharge air stream passing therethrough and aperture 138 that size increases.

Fig. 4-6 also illustrates the subregion in the first chamber 114 and the second chamber 118 in housing 102.As it was previously stated, chamber entrance 104 limits The entrance in fixed first chamber 114.Limiter component 130 be located at the first chamber 114 in respect to seat 124 around chamber entrance 104 so that it Can move between a closed position and a open position, in closed position, along the discharge of flow path 110 transit chamber entrance 104 of feeling elated and exultant Air stream is restricted, and in open position, the discharge air stream of transit chamber entrance 104 is limited by less.Equally, optionally Variable-nozzle 136 is installed around chamber passage 116 or is located in chamber passage 116 so that entering the discharge air circulation in the first chamber 114 The first chamber 114 is left in the aperture 138 crossing variable-nozzle 136.Telling of first chamber 114 is left by the aperture 138 of variable-nozzle 136 Go out air and enter the second chamber, the second chamber is limited by the space being occupied by blade 132 and guiding walls 120 in housing 102.According to blade 132 position, can be left by least one of the first chamber outlet 106 and the second chamber outlet 108 after the air of discharge Second chamber 118.

Fig. 8-14 illustrates in greater detail the internal part of OPEP device 100.Be turning initially to Fig. 8-9, front perspective view and after Parallax stereogram illustrates to be operatively connectable to the limiter component 130 of blade 132 by axle 134.So, limiter component 130 Can rotate around axle 134 with blade 132 so that the rotation of limiter 130 causes the corresponding rotation of blade 132, vice versa.With Housing 102 is identical, and limiter component 130 and blade 132 can be made up of any durable material and constitute, such as polymer.Preferably, They are made up of the plastics of lower shrinkage low friction.A kind of such material is acetal.

As illustrated, limiter component 130, blade 132 and axle 134 are formed as single part.Limiter component 130 is substantially For dish type, and blade 132 is plane.Limiter component 130 includes the face 140 being axially offset from the substantial circular of axle 134 The inclination engaging with the seat 124 being formed as with formed around chamber entrance 104 or chamfered edge 142.In this way, limiter structure Part 130 is suitable to move around the rotation axiss that axle 134 is limited with respect to chamber entrance 104 so that limiter component 130 can close Closed position is engaged with seat 124, with substantially sealed and limit discharge air stream transit chamber entrance 104.However, it is contemplated that limiter structure Part 130 and blade 132 are formed as the separating component that can be connected by any suitable device so that they still can independently be replaced Change limiter component 130 and the blade 132 of different shape, size or the weight selecting to keep ideal operating conditions into. For example, limiter component 130 and/or blade 132 may include the wide surface of one or more fixed wheels.Alternatively, limiter structure Part 130 can be configured to butterfly valve.

Turn to Figure 10, show limiter component 130 and the front view of blade 132.As it was previously stated, limiter component 130 Including the substantial circular face 140 being axially offset from axle 134.Limiter component 130 also includes being designed to promote limiter Second deviation of component 130 movement between a closed position and a open position.More specifically, the face 140 of limiter component 130 Center 144 deviate by being radially offset from the plane limiting with axle 134 or rotation axiss.In other words, positioned at the limit of the side of axle 134 The surface area in the face 140 of device component 130 processed is more than the surface area of the opposite side in axle 134.Chamber entrance from the air spuing Pressure at 104 produces the power acting on the face 140 of limiter 130.Center 144 due to the face 140 of limiter component 130 Deviate as described above, resulting force difference produces the moment of torsion around axle 134.As explained further below, this moment of torsion promotes to limit Device component 130 movement between a closed position and a open position.

Turn to Figure 11, show limiter component 130 and the top view of blade 132.As illustrated, blade 132 with respect to It is connected to axle 134 to the 75 ° of angles in 140 one-tenth of face of limiter 130.Preferably, described angle will remain between 60 ° and 80 °, but it is envisioned that The angle of blade 132 can be selectively adjusted, to keep preferable operating condition, as previously discussed.Moreover it is preferred that Blade 132 and limiter component 130 are configured to, when OPEP device 100 be assembled complete when, when limiter component 130 is in So that the angle between the centrage of variable-nozzle 136 and blade 132 is between 0 ° and 25 ° during closed position.Additionally, no matter joining How put, the center of gravity of the combination of limiter component 130 and blade 132 preferably has is alignd with axle 134 or rotation axiss.At this In bright full view, it will be apparent to those of ordinary skill in the art that the angle of blade 132 can be subject to size or the shape of housing 102 Shape limits, and normally will be less than the half that blade 132 and limiter component 130 always rotate.

Turn to Figure 12 and 13, be shown without the front perspective view of variable-nozzle 136 that discharge air stream passes through and backsight stands Body figure.Usually, variable-nozzle 136 includes top and bottom wall 146, side wall 148 and formation V-arrangement slit 150 betwixt.As schemed Show, variable-nozzle is substantially formed as duck-beak type valve.However, it is understood that can also using the nozzle of other shapes and size or Valve.Variable-nozzle 136 may also include and is configured to variable-nozzle 136 is arranged in housing 102 in the first chamber 114 and the second chamber Lip 152 between 118.Variable-nozzle 136 can be by any material with suitable elasticity（Such as silicones）Constitute or mould Become, and according to manufacturing capacity, preferably there is wall thickness between 0.50 and 2.00 millimeter and between 0.25 to 1.0 millimeter or Less aperture width.

As it was previously stated, variable-nozzle 136 is optional in the operation of OPEP device 100.It should also be understood that OPEP device 100 alternatively omit chamber passage 116 and variable-nozzle 136, and therefore include single chamber embodiment.Although invariable Also work in the case of nozzle 136, but when OPEP device 100 is operated together with variable-nozzle 136, OPEP device can be improved 100 performances in broader flow rates venting one's pent-up feelings.Chamber passage 116（When being used in the case of there is no variable-nozzle 136 When）Or the aperture 138 of variable-nozzle 136（When including variable-nozzle 136）Discharge for producing the speed with increase is empty Gas blowout jet.As explained in further detail below, the speed entering the increase of discharge air in the second chamber 118 causes by the sky that spues The power that gas applies to blade 132 proportionally increases, and then causes the moment of torsion around axle 134 to increase, and these all affect to manage Think operating condition.

In the case of not having variable-nozzle 136, the aperture between the first chamber 114 and the second chamber 118 is according to chamber passage 116 Size, shape and area of section and fixed, these all can be selectively adjusted by any suitable means, such as passes through Change intermediate section 103 or the rear portion section 105 of housing.On the other hand, when OPEP device 100 includes variable-nozzle 136 When, the aperture between the first chamber 114 and the second chamber 118 is by the size in aperture 138 of variable-nozzle 136, shape and area of section Limit, these can be according to the pressure change in the flow velocity of discharge air and/or the first chamber 114.

Turn to Figure 14, show the front perspective view of the variable-nozzle 136 that discharge air flows through wherein.Shown in Figure 14 The one side of variable-nozzle 136 is, when aperture 138 is opened in response to the discharge air flowing through wherein, aperture 138 Cross sectional shape keep rectangular shape, this apply OPEP therapy during cause by variable-nozzle 136 from the first chamber 114 （See Fig. 3 and 5）Relatively low reduced pressure to the second chamber 118.By being formed at the V-arrangement between top and bottom wall 146 and side wall 148 Slit 150 realizes the rectangular shape unanimous on the whole in the aperture 138 of variable-nozzle 136 in increased flow velocity, and slit 150 is used for Side wall 148 is allowed to bend without restriction.Preferably, V-arrangement slit 150 is as thin as possible, to minimize the discharge passing through wherein Air leaks.For example, V-arrangement slit 150 can be approximate 0.25 mm wide, but according to manufacturing capacity, can be at 0.10 and 0.50 millimeter Between change.Flow path is felt elated and exultant by the second chamber from housing 102 projection by the final edge of the discharge air of V-arrangement slit 150 leakage Guiding walls 120 in 118 guide.

It should be understood that many factors are all to variable-nozzle 136, and the impact of the performance to OPEP device 100 contributes, including The geometry of variable-nozzle 136 and material.Only for example, in order to obtain under the flow velocity venting one's pent-up feelings of 15 Liter Per Minutes 10 to Target oscillation pressure frequency between 13Hz, in one embodiment, can be using 1.0 passages taking advantage of 20.0 millimeters or aperture.But That, when flow velocity venting one's pent-up feelings increases, the frequency of the oscillation pressure in this embodiment also increases, but compared with target frequency increase speed Rate is too fast.In order to obtain the target oscillation pressure frequency between 18 to 20Hz under the flow velocity venting one's pent-up feelings of 45 Liter Per Minutes, same Embodiment can be using 3.0 passages taking advantage of 20.0 millimeters or aperture.This relation demonstrates the area of section in expectation passage or aperture Expand when flow velocity venting one's pent-up feelings increases, to limit the reduced pressure across variable-nozzle 136.

Turn to Figure 15 A-C, the top perspective of OPEP device 100 illustrates the exemplary diagram of the operation of OPEP device 100 Show.Specifically, Figure 15 A illustrates that limiter component 130 is in initial or closed position, in this position, the telling of transit chamber entrance 104 Go out air stream to be restricted, and blade 132 is in primary importance, towards the first chamber outlet 106 guiding discharge air stream.Figure 15B illustrates that limiter component 130 is in a partly opened position, and in this position, the discharge air stream of transit chamber entrance 104 is subject to more Few restriction, and blade 132 directly alignd with the discharge air jet stream leaving variable-nozzle 136.Figure 15 C illustrates limiter Component 130 is in an open position, and in this position, the discharge air stream of transit chamber entrance 104 is limited by even less, and Blade 132 is in the second position, towards the second chamber outlet 108 guiding discharge air stream.It should be understood that circulation described below is only It is the example of the operation of OPEP device 100, and many factors can be to cause and described circulation mode devious shadow Ring the operation of OPEP device 100.But, in OPEP device 100 during the operation, limiter component 130 and blade 132 will substantially exist Move back and forth between position shown in Figure 15 A and 15C.

During applying OPEP therapy, limiter component 130 and blade 132 initially can be located at position as shown in fig. 15. In this position, limiter component 130 is in the closed position, in this position, along the discharge air of path transit chamber entrance 104 of feeling elated and exultant Stream is substantially limited.So, when user is felt elated and exultant to mouthpiece 108, the pressure venting one's pent-up feelings at chamber entrance 104 starts to increase.With The pressure venting one's pent-up feelings at chamber entrance 104 increases, and the corresponding force acting on the face 140 of limiter component 130 increases.Solve as front Release, because the center 144 in face 140 is deviateed by being radially offset from the plane limiting with axle 134, therefore gained resulting net force produces around axle Negative torque or open torque.Then, open torque biasing limiter component 130, with Unscrew, allows discharge air enter the One chamber 114, and blade 132 is biased to away from its primary importance.When limiter component 130 is opened and allows discharge air to enter When entering the first chamber 114, the pressure at chamber entrance 104 starts to reduce, and the power on the face 140 of limiter component that acts on starts to drop Low, and bias open limiter component 130 moment of torsion start reduce.

When discharge air transit chamber entrance 104 goes successively to the first chamber 114, it is along flow path 110 of feeling elated and exultant by housing 102 Guiding, until it reaches the chamber passage 116 being located between the first chamber 114 and the second chamber 118.If OPEP device 100 is not having Operate in the case of variable-nozzle 136, because area of section reduces, discharge air accelerates transit chamber passage 116, to form discharge Air jet stream.Equally, if OPEP device 100 operates in the case of having variable-nozzle 136, discharge air accelerates logical Cross the aperture 138 of variable-nozzle 136, wherein, outwards scratched by the side wall 148 that the pressure in aperture 138 causes variable-nozzle 136 Song, thus increases the size in aperture 138 and the caused discharge air stream passed through wherein.With regard to some discharge air from can For becoming V-arrangement slit 150 leakage of nozzle 136, it is projected into shell by towards discharge air jet stream and along flow path of feeling elated and exultant Guiding walls 120 guiding in body 102 returns.

Then, when discharge air passes through variable-nozzle 136 and/or chamber passage 116 leaves the first chamber 114 and enters the second chamber When 118, it is guided towards the forward section 101 of housing 102 by blade 132, and wherein, it is in the first chamber outlet by opening 106 leave OPEP device 100 is forced to reverse direction before.Discharge air due to forward section 101 towards housing 102 Direction changes, and therefore pressure accumulates in the second chamber 118 at the forward section 101 of housing 102, thus in adjacent leaf Power is caused on piece 132, and produces the extra negative torque around axle 134 or open torque.By acting on limiter component 130 Face 140 and blade 132 on power and the open torque of combination that produces around axle 134 causes limiter component 130 and blade 132 around axle 134 from Figure 15 A shown in be positioned against shown in Figure 15 B position rotation.

When limiter component 130 and blade 132 rotate to the position shown in Figure 15 B, blade 132 is across leaving variable spray The discharge air jet stream of mouth 136 or chamber passage 116.Initially, leave the discharge air spray of variable-nozzle 136 or chamber passage 116 Jet provides power on blade 132, this power together with the momentum of blade 132, axle 134 and limiter component 130 by blade 132 and Limiter component 130 is advanced to the position shown in Figure 15 C.But, around the position shown in Figure 15 B, come from leave variable Negative torque or open torque are also switched to positive-torque or close torsion by power on blade 132 for the discharge air effect of nozzle 136 Square.More specifically, when discharge air is left the first chamber 114 and entered the second chamber 118 by variable-nozzle 136, it is by blade 132 guide towards the forward section 101 of housing 102, and in this place, it leaves OPEP dress in the second chamber outlet 108 by opening It is forced to reverse direction before putting 100.Direction due to the discharge air of the forward section 101 towards housing 102 changes, Therefore pressure accumulates in the second chamber 118 at the forward section 101 of housing 102, thus causes on adjacent blades 132 Power, and produce the positive-torque around axle 134 or closing torque.Continue to move to more with blade 132 and limiter component 130 Near the position shown in Figure 15 C, pressure accumulates in the second chamber 118 at the forward section 101 of housing 102, and then, With flowing along flow path 110 of feeling elated and exultant and flowing through the discharge air of chamber entrance 104 by even less limiting, around axle 134 Positive-torque or closing torque continue increase.Simultaneously although come from the power acting on limiter component 130 around axle 134 moment of torsion also switches to positive-torque or closing torque from negative torque or open torque around the position shown in Figure 15 B, but When the position shown in the position shown in limiter component 130 and blade 132 are from Figure 15 B rotates to Figure 15 C, this torque is real Negligible in matter.

After reaching the position shown in Figure 15 C, and the positive-torque around axle 134 due to increasing or closing torque, Blade 132 and limiter component 130 reverse direction simultaneously return initially towards the position rotation shown in Figure 15 B.When blade 132 and limit When the stream venting one's pent-up feelings of position shown in close to Figure 15 B for the device component 130 processed and transit chamber entrance 104 is increased by limiting, around The positive-torque of axle 134 or closing torque start to reduce.When limiter component 130 and blade 132 rotate to the position shown in Figure 15 B When 130, blade 132, across the discharge air jet stream leaving variable-nozzle 136 or chamber passage 116, thus produces on blade 132 Raw power, blade 132 and limiter component 130 are advanced together with the momentum of blade 132, axle 134 and limiter component 130 by this power Return to the position shown in Figure 15 A.After limiter component 130 and blade 132 return to the position shown in Figure 15 A, pass through The discharge air stream of chamber entrance 104 is restricted, and above-mentioned circulating repetition its own.

It should be understood that during the single cycle venting one's pent-up feelings, above-mentioned circulation will be repeated many times over.Therefore pass through in closed position and Repeat catch arrangement component 130, the discharge air stream of wherein transit chamber entrance 104 is subject in closed position between open position Limit, the discharge air stream of transit chamber entrance 104 is less limited in open position, vibration back pressure is sent to OPEP device 100 user, and OPEP therapy is applied.

Turning now to Figure 16-17, show the alternate embodiment of variable-nozzle 136.Variable-nozzle 236 can be used for OPEP In device 100, as the replacement of above-mentioned variable-nozzle 136.As shown in figs. 16-17, variable-nozzle 236 include aperture 238, top and Diapire 246, side wall 248 and lip 252, lip is configured to be pacified variable-nozzle 236 with variable-nozzle 136 identical mode It is contained in the housing of OPEP device 100 between first chamber 114 and the second chamber 118.With variable-nozzle 136 class shown in Figure 12-13 Seemingly, variable-nozzle 236 can be by any material with suitable elasticity（Such as silicones）Constitute or be molded as.

During applying OPEP therapy, when the aperture 238 of variable-nozzle 236 is in response to the discharge air that flows through wherein When opening, the cross sectional shape in aperture 238 keeps rectangular shape, and this causes by variable-nozzle 236 from the first chamber 114 to the The relatively low reduced pressure in two chambeies 118.Realized during increased flow velocity by the thin corrugated wall being formed in top and bottom wall 246 The rectangular shape unanimous on the whole in the aperture 238 of variable-nozzle 236, this bends with allowing the more easily less resistance of side wall 248. Another advantage of the present embodiment is that top and bottom wall 246 does not exist when discharge air flows through the aperture 238 of variable-nozzle 236 Leakage, such as passes through the leakage of the V-arrangement slit 150 of variable-nozzle 136 shown in Figure 12-13.

Those skilled in the art it will be understood that in some applications, may only expect PEP（There is not vibration）, In this situation, OPEP device 100 can not have limiter component 130 but alternatively having fixing aperture or manually adjustable Operate in the case of aperture.PEP embodiment may also include variable-nozzle 136 or variable-nozzle 236, to keep being in Relatively uniform back pressure in expected range.

2nd OPEP embodiment

Turning now to Figure 18-19, show front perspective view and the rear perspective view of the second embodiment of OPEP device 200. The configuration of OPEP device 200 and operation are similar to the configuration of OPEP device 100 and operation.But, such as Figure 20-24 best seen from , OPEP device 200 also includes governor motion 253, and this governor motion 253 is suitable to change chamber entrance 204 with respect to housing 202 He The relative position of limiter component 230, limiter component 230 changes the rotation of the blade 232 being operatively connected with it then Scope.As explained below, user therefore, it is possible to be conveniently adjusted the OPEP therapy that OPEP device 200 is applied frequency and Amplitude, without the part opening housing 202 with disassemble OPEP device 200.

OPEP device 200 generallys include housing 202, chamber entrance 204, the first chamber outlet 206（Figure 23 and 32 most preferably may be used See）, second chamber outlet 208（Most preferably visible in Figure 23 and 32）And the mouthpiece 209 with chamber entrance 204 fluid communication.With OPEP As device 100, the forward section 201 of housing 202, intermediate section 203 and rear portion section 205 are separable, thus can root According to keep ideal operating conditions needs periodically close, clean, change or reconfigure the part being included in.OPEP Device also includes adjustable rotating disk 254, as described below.

As discussed above in conjunction with OPEP device 100, OPEP device 200 may be adapted to make together with other or extra interface With such as aerosol delivery device.In this regard, OPEP device 200 is equipped with the suction being in fluid communication with mouthpiece 209 and chamber entrance 204 Gas port 211（Most preferably visible in Figure 19,21 and 23）.As it appears from the above, suction port may include single check valve（Do not show Go out）, the air of surrounding is sucked by check valve with the user allowing OPEP device 200 and transit chamber entrance 204 is felt elated and exultant, and Do not need to exit the mouthpiece 209 of OPEP device 200 between air-breathing and cycle venting one's pent-up feelings.Additionally, aforementioned aerosol delivery device can It is connected to suction port 211, to apply aerosol and OPEP therapy simultaneously.

Figure 20 illustrates the exploded view of OPEP device 200.In addition to the part of above-mentioned housing, OPEP device 200 includes leading to Cross limiter component 230, governor motion 253 and the variable-nozzle 236 that pin 231 is operatively connectable to blade 232.As Figure 21 Shown in sectional view, when OPEP device 200 is in use, variable-nozzle 236 be located at housing 202 intermediate section 203 and after Between portion's section 205, and governor motion 253, limiter component 230 and blade 232 form assembly.

Turn to Figure 21-23, show the various cross-sectional perspective view of OPEP device 200.As OPEP device 100, by void The flow path venting one's pent-up feelings 210 that line is pointed out is limited at least one of the first chamber outlet 206 and the second chamber outlet 208 and mouthpiece Between 209（Most preferably visible in Figure 23 and 32）.Due to being attached to the check valve on suction port 211（Not shown）And/or gas Mist agent delivery apparatus（Not shown）, flow path 210 venting one's pent-up feelings starts from being directed at mouthpiece 209 and towards chamber entrance 204, and it is in behaviour When making can by or can not be stopped by limiter component 230.Through after chamber entrance 204, flow path 210 venting one's pent-up feelings enters the One chamber 214 simultaneously turns 180 ° towards variable-nozzle 236.After the aperture 238 through variable-nozzle 236, flow path 210 venting one's pent-up feelings Enter the second chamber 218.In the second chamber 218, flow path 210 venting one's pent-up feelings can be by the first chamber outlet 206 or the second chamber outlet 208 At least one leave OPEP device 200.It will be apparent to one skilled in the art that the flow path venting one's pent-up feelings 210 pointed out by dotted line is to show Example property, and the air felt elated and exultant in OPEP device 200 advances to the first chamber outlet at it from mouthpiece 209 or chamber entrance 204 206 or second chamber outlet 208 in can along any amount of direction or path flowing.

Reference picture 24-25, illustrates the forward sight of governor motion 253 and the rear perspective view of OPEP device 200.Usually, adjust Section mechanism 253 includes adjusting rotating disk 254, axle 255 and framework 256.Projection 258 is located on the back side 260 adjusting rotating disk, and fits In limiting user, the selectivity of governor motion 253 is rotated, as described further below.Axle 255 includes key section 262, Key section 262 is adapted to fit in the upper bearing (metal) 226 and lower bearing 228 being formed in housing 200（See Figure 21 and 28-29）.Axle Also include axial eyelet 264, axial eyelet is configured to receive and is operatively connected to limiter component 230 and blade 232 Pin 231 together.As illustrated, framework 256 is spherical, and description below, it is configured to revolve with respect to housing 202 Turn, formed enough to allow to apply the sealing of OPEP therapy simultaneously between housing 202 and framework 256.Framework 256 is included by seat The circular open being suitable to receiving limiter component 230 of 224 restrictions.When using, circular open is used as chamber entrance 204.Framework 256 also include the retainer 222 for stoping limiter component 230 from being opened along wrong direction.

Turn to Figure 26, show limiter component 230 and the front perspective view of blade 232.Limiter component 230 and blade 232 design, material and configuration can be identical with the above-mentioned description with regard to OPEP device 100.But, the limit in OPEP device 200 Device component 230 processed and blade 232 are operatively connected by pin 231, and this pin 231 is adapted for insertion into the axle by governor motion 253 In 255 axial eyelet 264.Pin 231 can be for example made up of rustless steel.In this way, the rotation of limiter component 230 causes leaf The corresponding rotation of piece 232, vice versa.

Turn to Figure 27, show the forward sight of the governor motion 253 fitting together with limiter component 230 and blade 232 Axonometric chart.In this configuration it can be seen that limiter component 230 is placed with so that it can be with respect to framework 256 and seat 224 In closed position（As shown in the figure）And open position（Not shown）Between rotate, in closed position, along feeling elated and exultant, flow path 210 passes through The discharge air stream of chamber entrance 204 is restricted, and in open position, the discharge air stream of transit chamber entrance 204 is by less Limit.As previously mentioned, blade 232 is operatively connectable to limiter component 230 by extend through the pin 231 of axle 255, and And be suitable to as one man move with limiter component 230.It can further be seen that limiter component 230 and blade 232 are by governor motion 253 supports, governor motion itself can rotate in the housing 202 of OPEP device 200, description below.

Figure 28 and 29A-B is partial section it is illustrated that the regulation machine that is installed in the housing 202 of OPEP device 200 Structure 253.As shown in figure 28, governor motion 253 and limiter component 230 and blade 232 are around upper bearing (metal) 226 and lower bearing 228 are rotatably installed in housing 200 so that user can be using regulation rotating disk 254 rotation regulating mechanism 253.Figure 29A-29B also illustrates the process being installed and locked at governor motion 253 in the lower bearing 208 of housing 202.More specifically, The key section 262 of axle 255 is aligned and inserted into wherein with the rotation lock 166 being formed in housing 202, as shown in figure 29 a.Once axle 255 key section 262 is inserted in rotation lock 266, and axle 255 just rotates 90 ° to latched position, but still is freely rotatable.Adjust Mechanism 253 is mounted in the same manner and is locked in upper bearing (metal) 226.

Once the internal part of housing 200 and OPEP device 200 is assembled, just limit the rotation of axle 255, so that it Holding is in the latched position in rotation lock 166.As shown in the front view of the OPEP device 200 of Figure 30, two retainers 268th, 288 it is located on housing 202 so that they, when user will adjust rotating disk 254 and rotates to precalculated position, and are formed at tune Projection 258 on the back side 260 of section rotating disk 254 engages.For illustration purposes, the OPEP device 200 shown in Figure 30 do not have from Housing 202 extends through regulation rotating disk 254 or the governor motion 253 of opening 269.In this way, can suitably limit regulation to turn The rotation of the key section 262 of disk 254, governor motion 253 and axle 255.

Turn to Figure 31, show the partial section of the governor motion 253 being installed in housing 200.As previously mentioned, The framework 256 of governor motion 253 is spherical, and is configured to rotate with respect to housing 202, and in housing 202 and framework Formed between 256 enough to allow to apply the sealing of OPEP therapy.As shown in figure 31, the flexible cylindrical body 271 extending from housing 202 Surround the part of framework 256 completely, to form sealing the margin 270.Identical with housing 202 and limiter component 230, flexible cylindrical Body 271 and framework 256 can be made up of the plastics of lower shrinkage low friction.A kind of such material is acetal.In this way, seal The complete 360 ° of ground in edge 270 contact frameworks 256 and form the sealing of the admissible rotation running through adjustment means 253.

The selective control of OPEP device 200 is described now with reference to Figure 32 A-B, 33A-B and 34A-B.Figure 32 A-B is The partial section of OPEP device 200；Figure 33 A-B is the diagram of the controllability of OPEP device 200；And Figure 34 A-B is The top perspective view of OPEP device 200.Refer to as previously mentioned with respect to OPEP device 100, blade 232 and limiter component 230 are preferred Be configured to so that when OPEP device 200 be assembled complete when, when limiter component 230 is in the closed position, variable-nozzle Angle between 236 centrage and blade 232 is between 10 ° and 25 °.It should be appreciated, however, that OPEP device 200 is adjustable Section property is not only restricted to parameter described herein, and any amount of configuration can be selected for applying in ideal operating conditions OPEP therapy.

Figure 32 A illustrates that blade 232 becomes 10 ° of angles with the centrage of variable-nozzle 236, and 32B illustrates blade 232 and variable spray The centrage of mouth 236 becomes 25 ° of angles.Figure 33 A illustrated frame 256 is with respect to the needed position of variable-nozzle 236（Shown by dashed lines）, So that the angle between the centrage of variable-nozzle 236 and blade 232 is 10 ° when limiter component 230 is in the closed position. On the other hand, Figure 33 B illustrated frame 256 is with respect to the needed position of variable-nozzle 236（Shown by dashed lines）So that when restriction When device component 230 is in the closed position, the angle between the centrage of variable-nozzle 236 and blade 232 is 25 °.

Reference picture 34A-B, shows the side perspective of OPEP device 200.Configuration shown in Figure 34 A is corresponding to Figure 32 A With the diagram shown in 33A, wherein, the centrage of variable-nozzle 236 and blade when limiter component 230 is in the closed position Angle between 232 is 10 °.On the other hand, Figure 34 B corresponds to the diagram shown in Figure 32 B and 33B, wherein, when limiter structure When part 230 is in the closed position, the angle between the centrage of variable-nozzle 236 and blade 232 is 25 °.In other words, from Figure 34 A Position shown in Figure 34 B for the shown position, the framework 256 of adjustment means 253 has been rotated counterclockwise 15 °, thus also increases The admissible rotation of blade 232.

In this way, user can rotate regulation rotating disk 254, to be selectively adjusted chamber entrance 204 with respect to restriction Device component 230 and the direction of housing 202.For example, user can adjust rotating disk 254 by the position rotation shown in towards Figure 34 A, And thus rotating frame 256, to increase the frequency of OPEP therapy and the amplitude that OPEP device 200 is applied.Alternatively, use Person can adjust rotating disk 254 by the rotation of position shown in towards Figure 34 B, and thus rotating frame 256, to reduce OPEP device The frequency of OPEP therapy and amplitude that 200 are applied.Additionally, as shown in such as Figure 18 and 30, it is possible to provide labelling, to help make User sets the suitable configurations of OPEP device 200.

For the OPEP device according to OPEP device 200, also can achieve and referring to OPEP device 800 description Those similar operating conditions.

3rd OPEP embodiment

Turn to Figure 35-37, show another embodiment of OPEP device 300.OPEP device 300 is in the side of being selectively adjusted Noodles are similar to OPEP device 200.As most preferably visible in Figure 35,37,40 and 49, OPEP device 300 similar with OPEP device 300 Including governor motion 353, this governor motion 353 is suitable to change chamber entrance 304 with respect to housing 302 and limiter component 330 Relative position, limiter component 330 changes the rotating range of the blade 332 being operatively connected with it then.As previously mentioned with respect to OPEP device 200 explain, user therefore, it is possible to be conveniently adjusted the OPEP therapy that OPEP device 300 is applied frequency and Amplitude, without opening housing 302 and disassemble the part of OPEP device 300.The applying of OPEP therapy using OPEP device 300 With identical with describe above with respect to OPEP device 100 in other respects.

OPEP device 300 includes the housing 302 with forward section 301, rear portion section 305 and inner box 303.With aforementioned OPEP device is the same, and forward section 301, rear portion section 305 and inner box 303 are separable, thus can grasp according to keeping preferable The needs making condition are periodically close, clean, change or reconfigure the part being included in.For example, as Figure 35-37 institute Show, the forward section 301 of housing 302 and rear portion section 305 are via fastening together with joint is removably attached to.

The exploded view of Figure 38 illustrates the part of OPEP device 300 further.Usually, except forward section 301, posterior Outside section 305 and inner box 303, OPEP device 300 also includes mouthpiece 309, suction port 311, is located at mouthpiece 309 and suction port Check valve 384 between 311, governor motion 353, limiter component 330, blade 332 and variable-nozzle 336.

As visible in Figure 39-40, inner box 303 is configured to fit within housing 302 at forward section 301 and rear portion Between section 305, and partly limit the first chamber 314 and the second chamber 318.Axonometric chart shown in Figure 41-42 and sectional view In illustrate in greater detail inner box 303.First chamber outlet 306 and the second chamber outlet 308 are formed in inner box 303.Inner box 303 One end 385 is suitable to receive variable-nozzle 336, and keeps variable-nozzle 336 to be between rear portion section 305 and inner box 303.For The upper bearing (metal) 326 of support adjustment mechanism 353 and lower bearing 328 at least be partially formed in inner box 303.With above with respect to OPEP The flexible cylindrical body 271 of device 200 description is similar with sealing the margin 270, and inner box 303 also includes thering is the soft of sealing the margin 370 Property cylinder 371, engages for the framework 356 around governor motion 353.

Blade 332 is illustrated in greater detail in axonometric chart shown in Figure 43.Axle 334 extends from blade 332, and is formed There is key to engage corresponding key section in the eyelet 365 of limiter component 330.In this way, axle 334 by blade 332 and limits Device component 330 processed is operatively connected together so that blade 332 and limiter component 330 as one man rotate.

Limiter component 330 is illustrated in greater detail in axonometric chart shown in Figure 44-45.Limiter component 330 includes For receiving the keyhole eye 365 of the axle 334 extending from blade 332, and also include retainer 322.This retainer 322 limits institute Show the admissible rotation that limiter component 330 is with respect to the seat 324 of governor motion 353.As shown in the front view of Figure 46, with limit Device component 330 processed is similar to, and limiter component 330 also includes being designed to promote limiter component 330 in closed position and to open The deviation of the movement between position.More specifically, the limiter component being located on the side for receive axle 334 of eyelet 365 The surface area in 330 face 340 is more than the surface area on the opposite side of eyelet 365.As retouched above with respect to limiter component 130 State, this deviates the open torque producing during the cycle venting one's pent-up feelings around axle 334.

Figure 47 and 48 forward sight and rear perspective view illustrate in greater detail governor motion 353.Usually, governor motion bag Include framework 356, framework 356 is suitable to engage with the sealing the margin 370 of the flexible cylindrical body being formed on inner box 303.In framework 356 Circular open formed and be formed as accommodating the seat 324 of limiter component 330.In the present embodiment, seat 324 is further defined by chamber Entrance 304.Governor motion 353 also includes being configured to the arm 354 at the position that framework 356 extends to more than housing 302, with Just allow user OPEP device 300 be assembled complete when, be selectively adjusted the direction of described governor motion 353, and Thus adjust the direction of chamber entrance 304.Governor motion 353 also includes upper bearing (metal) 385 and lower bearing 386 for receive axle 334.

The solid of Figure 49 illustrates the assembly of blade 332, governor motion 353 and limiter component 330.As explained above , blade 332 and limiter component 330 are operatively connected together so that the rotation of blade 332 causes limit by axle 334 The rotation of device component 330 processed, vice versa.On the contrary, governor motion 353, and thus limit the seat of chamber entrance 304, it is configured Become to rotate around axle 334 with respect to blade 332 and limiter component 330.In this way, user can turning arm 354, with phase Limiter component 330 and housing 302 are selectively adjusted to the direction of chamber entrance 304.For example, user can be by along up time Pin direction turning arm 354 and thus rotating frame 356 increasing the frequency of the OPEP treatment that OPEP device 800 is applied and to shake Width.Alternatively, user can be by rotating regulating arm 354 and thus rotating frame 356 reduces OPEP in the counterclockwise direction The frequency of OPEP treatment and amplitude that device 300 is applied.Additionally, as shown in the example in Figure 35 and 37, can be on housing 302 There is provided labelling, to help user to set the suitable configurations of OPEP device 300.

Figure 50 and 51 forward sight and rear perspective view illustrate in greater detail variable-nozzle 336.In OPEP device 300 can Change nozzle 336 also includes substrate similar to the variable-nozzle 236 describing above with respect to OPEP device 200, simply variable-nozzle 336 387, substrate 387 is configured to fit within an end 385 of inner box 303（See Figure 41-42）Interior and keep variable-nozzle 336 It is between rear portion section 305 and inner box 303.Similar with variable-nozzle 236, variable-nozzle 336 and substrate 387 can be by silicones Make.

The front perspective view of Figure 52 illustrates in greater detail check valve 384.Usually, check valve 384 includes being suitable to install In the post 388 in the forward section 301 of housing 302 and the power or the pressure that are adapted on flap 389 and curved with respect to post 388 Flap 389 that is bent or pivoting.It will be apparent to one skilled in the art that can make in the present embodiment and other embodiments as described herein With other check valves without running counter to the teachings of the present invention.As visible in Figure 39-40, check valve 384 can be located at housing 302 In between mouthpiece 309 and suction port 311.

As discussed above with respect to OPEP device 100, OPEP device 300 may be adapted to make together with gas or extra interface With such as aerosol delivery device.With regard to this, OPEP device 300 is equipped with the suction port 311 being in fluid communication with mouthpiece 309（? Most preferably visible in Figure 35-36 and 38-40）.As it appears from the above, suction port may include single check valve 384（In Figure 39-40 and Most preferably visible in 52）, it is configured to permit the user of OPEP device 300 by the air around check valve 384 suction simultaneously And transit chamber entrance 304 is venting one's pent-up feelings, without the mouthpiece 309 exiting OPEP device 300 between air-breathing and cycle venting one's pent-up feelings.This Outward, aforementioned commercially available aerosol delivery device may be connected to suction port 311, to apply aerosol simultaneously（In air-breathing） With OPEP therapy（When venting one's pent-up feelings）.

The sectional view of Figure 39-40 illustrates above-mentioned OPEP device 300 and part further.For illustration purposes, the figure illustrating 39 sectional view does not have the totality part of OPEP device 300.

Forward section 301, rear portion section 305 and inner box 303 are assembled to form the first chamber 314 and the second chamber 318.With OPEP device 100 is similar to, and is limited at the first chamber outlet 306 by the flow path venting one's pent-up feelings 310 that dotted line is pointed out（In Figure 39-40 and 42 In most preferably visible）Export 308 with the second chamber（Most preferably visible in Figure 41）One of and mouthpiece 309 between, the outlet of two chambeies It is formed in inner box 303.Due to suction port 311 and check valve 348, flow path 310 venting one's pent-up feelings starts from mouthpiece 309 direction Chamber entrance 304 is directed, its operation when can by or can not be stopped by limiter component 330.Through chamber entrance 304 it Afterwards, flow path 310 venting one's pent-up feelings enters the first chamber 314 and turns 180 ° towards variable-nozzle 336.Through variable-nozzle 336 After aperture 338, flow path 310 venting one's pent-up feelings enters the second chamber 318.In the second chamber 318, flow path 310 venting one's pent-up feelings can pass through first The second chamber 318 is left at least one of chamber outlet 306 or the second chamber outlet 308, and eventually off housing 302.This area skill Art personnel be readily apparent that, the flow path venting one's pent-up feelings 310 pointed out by dotted line is exemplary, and is felt elated and exultant in OPEP device 300 Air can be along any quantity when mouthpiece 309 or chamber entrance 304 advance to the first chamber outlet 306 or the second chamber outlet 308 at it Direction or path flowing.As noted, the administration of the OPEP therapy being carried out using OPEP device 300 in other respects with On with regard to OPEP device 100 description identical.

Only for example, following operating condition or performance characteristic be can achieve by the OPEP device according to OPEP device 300, Wherein, adjust rotating disk 354 and set frequency and amplitude for increasing：

Flow velocity（lpm）	10	30
			Frequency（Hz）	7	20
Upper pressure（cm H2O）	13	30
			Low pressure（cm H2O）	1.5	9
Amplitude（cm H2O）	11.5	21

In the case that regulation rotating disk 354 is set for frequency and the amplitude of reduction, frequency and amplitude can reduce, for example, closely Like 20%.Other frequencies and amplitude target can be realized by the particular configuration or size that change element, for example, increase blade 332 Length cause slower frequency, and the size reducing aperture 338 causes higher frequency.Example above is only according to above-mentioned reality Apply one group of feasible operating condition of the OPEP device of example.

Pressure indicator for OPEP device

Medical industry lack for OPEP device cheap, meet human engineering, small-sized, portable pressure indicator side Case.For example, most of commercially available piezometers are the large-scale stationary apparatus that can be connected by pipe, and this makes them heavy and not beautiful See.Additionally, most of commercially available piezometers are that plan is reusable, this can lead to propagate the risk of infectious disease.This Outward, existing piezometer is not configured as or plans to read and provide the visual feedback of oscillation pressure, is such as applying Those producing in OPEP device during OPEP therapy.This kind of piezometer and OPEP are used together and can lead to pressure output reading Undue fluctuation so that the user of device or his or her clinician are difficult to accurately be fed back.

Embodiment described herein providing the pressure indicator meeting human engineering, it is easily whole with existing OPEP device Close, and be suitable to be reused by single patient.Additionally, these embodiments are configured to make to be supplied to the visual feedback of user In vibration minimize, the therefore readable stress level of allowable pressure indicator for displaying, and simultaneously provide dynamic vision feedback, To allow user know that OPEP device works by perceiving its oscillation pressure.

Although pressure indicator embodiment described herein is shown and described into and is made together with the OPEP device 300 of Figure 35 With it should be understood that pressure transducer is further adapted for being used together with other OPEP devices, including for example：Described herein its His OPEP device；United States Patent (USP) No.5,018,517；No.6,581,598；No.6,776,159；No.7,059,324；No.8, 327,849；No.8,539,951；And No.8, with those describing shown in 485,179, the whole of these patents pass through to quote It is herein incorporated；U.S. Patent application No.13/489,894 and No.14/092, with those describing shown in 091, these applications Whole be incorporated herein by reference；And any amount of commercially available OPEP device, such as it is derived from Canadian London The AEROBIKA of Trudell Medical International company, the Smiths from St. Paul, MN The ACAPELLA of Medical company, the Axcan Scandipharm Inc. company from Birmingham, Alabama The FLUTTER and RC-CORONET of the Curaplex company from Ohio Dublin.

The first embodiment of pressure indicator

Turn to Figure 53-56, show the first embodiment of pressure indicator 400.Usually, pressure indicator 400 includes body 402nd, from body 402 conduit 404 extending, the plug 406 placed along conduit 404 and be inserted and be located at going out of conduit 404 Instruments for pressure measurement in piezometer 408 form at mouthful.

Body 402 is dimensioned and is shaped to be integrated with existing OPEP device, for example, as shown in figure 54, with OPEP device 300 mouthpiece 309 is integrated.In the present example, body 402 includes the male/female adapter of 22mm ISO taper, and this adapter is formed Be sized to be connected with the mouthpiece 309 of OPEP device 300.

The conduit 404 extending from body 402 is configured to be sent to pressure in OPEP device 300 piezometer 408.Enter Mouth 405 allows the pressure transmission in bodies 402 in conduit 404.As illustrated, conduit 404 extends away from body 402, then It is at an angle of on OPEP device 300 side, thus keep the portability of OPEP device 300 and meet human engineering, and avoid Needs to long tube or extra attachment structure.

Piezometer 408 is located at the outlet 403 of conduit 404.It should be appreciated, however, that the part of conduit 404 may extend into pressure In the passage of power meter 408 or for measuring in the other instruments of pressure.Piezometer 408 can be piston-type measurement device, such as, example As from the AMBU Disposable Pressure Manometer of the Ambu A/S company of Copenhagen, Denmark.Also may be used Replace piezometer 408 using other instruments for pressure measurement.Usually, piezometer 408 includes spring-loaded piston, It is in response to the indicator in the mobile piston of pressure change.Preferably, instruments for pressure measurement may include numerical value, color, One or more of shape or other visual indicia, or one or more of sound or other audition labellings, or regard Feel each combination with one or more of audition labelling in labelling.In one of exemplary embodiment shown in Figure 53, Piezometer 408 includes the numeric indicia 409 of the pressure measured by indicator gage 408.Preferably, instruments for pressure measurement Be placed with respect to respiratory therapy apparatus so that during treating indicator and labelling visible to user.As showing of Figure 54 Example property embodiment shown in, piezometer 408 be placed with respect to the respiratory therapy apparatus in OPEP device 300 form so that During treatment, indicator and labelling 409 are visible to the user of OPEP device 300.

Plug 406 passes through pressing and can insert at the point that OPEP device 300 side is at an angle of in conduit 404 along conduit 404.? In one embodiment, piston can be not removed, but can be made up of self encapsulant, such as silicone material, allow pin or Other like instrument are inserted for cleaning purpose and are removed and keep sealing.In another embodiment, can periodically move Except plug, so that cleaning pressure indicator 400.As most preferably visible in Figure 56 C-E, plug 406 include can with logical in conduit 404 The otch 409 of road 410 alignment.When piston 406 be inserted in conduit 404 so that otch 409 with passage 410 partially or completely During ground alignment, conduit 404 forms pressure stability aperture 407.As explained below, pressure stability aperture 407 is configured to Damping is sent to the vibration of the pressure of piezometer 408 from OPEP device 300.

As shown in Figure 56 C-E, by with respect to passage 410 rotating piston 406, pressure stability aperture can be selectively adjusted 407 size and dimension, thus increases or decreases the amount of damping.Although pressure stability aperture 407 is shown to be adjustable, It is it should be understood that the size and dimension in pressure stability aperture 407 can be fixing.Further, it will be appreciated that pressure stability aperture 407 can be located at any position between body 402 and piezometer 408 along conduit 404, for example, as seen in Figure 56 F, or Person be located at extend to conduit 404 in piezometer 408 partly in, or be located at the part forming instruments for pressure measurement Passage in, for example, as seen in Figure 56 G.But, in order that pressure stability aperture 407 damps effectively from OPEP dress Put the vibration of 300 pressure being sent to piezometer 408, along the whole length of conduit 404, the section face in pressure stability aperture 407 The long-pending area of section that should be less than conduit 404.In the present embodiment, a diameter of 0.5mm to 1.5mm in pressure stability aperture 407, Or area of section is in 0.196mm²And 1.767mm²Between.Preferably, a diameter of 0.6mm in pressure stability aperture 507 is extremely 0.9mm, or area of section is in 0.283mm²And 0.636mm²Between.

It is explained in greater detail as described above with various OPEP embodiments, during applying OPEP therapy, vibrate back pressure quilt It is sent to the user of OPEP device, it is received by user at mouthpiece.When pressure indicator 400 is connected to this OPEP Device（Such as OPEP device 300）When, oscillation pressure is sent to piezometer 408 by conduit 404 in body 402.But, When the air stream flowing through pressure stability aperture 407 along conduit 404 is restricted, by the pressure of pressure stability aperture 407 Vibration is damped.After pressure is damped by pressure stability aperture 407, it is received and measured, piezometer by piezometer 408 Then provide visually indicating of the pressure realized during applying OPEP therapy to user.This allows user or caregiver prison Control treatment rule or therapy, to guarantee to realize suitable pressure within the time period of regulation.In some instances it may be desirable to Be, between feeling elated and exultant within a predetermined period of time under high pressure and feeling elated and exultant within a predetermined period of time under low pressure alternate treat rule or Therapy.The vision of pressure realized during treating or audible indication will allow for user or caregiver and determine deferring to controlling of regulation Treat the level of rule or therapy.

Turn to Figure 56 H-56I, there is provided, when with the Trudell Medical from Canadian London When the AEROBIKA OPEP device of International company is used in conjunction with, will be using not having pressure stability aperture（Figure 56H）The pressure oscillation observed of the pressure indicator according to the present embodiment with there is pressure stability aperture（Figure 56 I）Basis The diagram that the pressure indicator of the present embodiment compares.The pressure observed also is listed in the following table：

It was additionally observed that, the performance of its attached OPEP device can not adversely be affected using pressure indicator 400, or from attached It is connected to the sprayer delivery aerosol medication on this OPEP device.

The second embodiment of pressure indicator

Turn to Figure 57-59, show the second embodiment of pressure indicator 500.Usually, pressure indicator 500 includes body 502nd, from body 502 extend conduit 504, along conduit 504 place cap 506 and be located at conduit 504 exit be in piezometer The instruments for pressure measurement of 508 forms.

Body 502 is dimensioned and is shaped to be integrated with existing OPEP device, for example, as shown in figure 58, with OPEP device 300 mouthpiece 309 is integrated.In the present example, body 502 equally includes the male/female adapter of 22mm ISO taper, this adapter quilt Molding and be sized to the composition being connected with the mouthpiece 309 of OPEP device 300.

The conduit 504 extending from body 502 is configured to be sent to pressure in OPEP device 300 piezometer 508.Enter Mouth 505 allows the pressure in bodies 502 to pass through to enter in conduit 504.As illustrated, conduit 504 only extends one away from body 502 Little segment distance, to allow for being connected to piezometer 508, thus keeps the portability of OPEP device 300 and meets ergonomic Learn, and avoid the needs to long tube or extra attachment structure.

Piezometer 508 is located at the outlet 503 of conduit 504.It should be appreciated, however, that the part of conduit 504 may extend into use In the instrument of measurement pressure, in such as piezometer 508.Piezometer 508 can be rotating disc type quantifier, such as, for example, be derived from The MERCURY MEDICAL Disposable of the Mercury Medical company of Florida State gram Lille water Pressure Manometer.It is also possible to use other for measurement from respiratory therapy apparatus（Such as OPEP device）Pressure Instrument is replacing piezometer 508.Usually, piezometer 508 includes indicator, and this indicator is in response to pressure in one embodiment Power changes and rotates.Preferably, piezometer 408 includes the labelling 409 of the pressure measured by indicator gage, for example, numeral, face Color coding etc..As illustrated, piezometer 508 be placed with respect to OPEP device 300 so that during treating indicator and mark Note 409 is visible to the user of OPEP device 300.

Pressure stability aperture 507 is located at along conduit 504.But pressure stability aperture 507 may be alternatively located at and extends to piezometer Conduit 504 in 508 partly in, or be located at and form the conduit of part of instruments for pressure measurement or other passages In.In the present embodiment, pressure stability aperture 507 has fixing shape and size, and a diameter of 0.5mm to 1.5mm, or Person's area of section is in 0.196mm²And 1.767mm²Between.Preferably, a diameter of 0.6mm to 0.9mm in pressure stability aperture 507, Or area of section is in 0.283mm²And 0.636mm²Between.

Cap 506 can be by pressing insertion conduit 504.Cap 506 can periodically be removed, so that cleaning pressure indicator 500.Different from the plug 406 in pressure indicator 400, cap 506 is not alignd with passage, and does not form pressure stability aperture 507 Part.

Pressure indicator 500 is in other respects to operate with above-mentioned pressure indicator 400 identical mode.

Turn to Figure 59 D-59E, there is provided, when with the Trudell Medical from Canadian London When the AEROBIKA OPEP device of International company is used in conjunction with, will be using not having pressure stability aperture（Figure 59D）The pressure oscillation observed of the pressure indicator according to the present embodiment with pressure stability aperture had according to the present invention （Figure 59 E）The diagram that compares of pressure indicator.The pressure observed also is listed in the following table：

It was additionally observed that, using pressure indicator 500 can not adversely affect to be attached to the performance of OPEP device thereon or from It is attached to the sprayer delivery aerosol medication on this OPEP device.

The 3rd embodiment of pressure indicator

Turn to Figure 60-61, the 3rd embodiment of pressure indicator 600 is shown connect to OPEP device 300.Pressure indicator 600 are from the different of pressure indicator 500, pressure indicator 600 be dimensioned and be shaped to for existing OPEP device Integrate, for example, as shown in figure 60, suction port 311 with OPEP device 300（See also Figure 35-35 and 40）Integrate.

As pressure indicator 500, pressure indicator 600 include body 602, from body 602 extend conduit 604, Entrance 605 and outlet 603, the rotating disc type positioned at the cap 606 along conduit 604, the end positioned at conduit 604 to conduit 604 Piezometer 608 and pressure stability aperture 607.As illustrated, piezometer 608 be placed with respect to OPEP device 300 so that During treating, indicator and labelling are visible for the user of caregiver and/or OPEP device 300.

Pressure indicator 600 also includes positioned at the check valve 684 in body 602 and extends to OPEP dress in body 602 Put the thorn 612 in 300 suction port 311.Check valve 684 is configured to when air-breathing at the mouthpiece 309 of OPEP device 300 Open, and close when when venting one's pent-up feelings.Thorn 612 is configured to for check valve 384 to be maintained at open position, thus make body 602 with Mouthpiece 309 is in fluid communication.

In operation, pressure indicator 600 is configured to be operated with above-mentioned pressure indicator 500 identical mode, and And provide and the pressure indicator 500 identical visual feedback being connected on the mouthpiece 309 of OPEP device 300.

The fourth embodiment of pressure indicator

Turn to Figure 62-63, the fourth embodiment of pressure indicator 700 is shown connect to OPEP device 300.Pressure indicator 700 are from the different of pressure indicator 400, pressure indicator 700 be dimensioned and be shaped to for existing OPEP device Integrate, for example, as shown in Figure 62, suction port 311 with OPEP device 300（See also Figure 35-35 and 40）Integrate.

As pressure indicator 400, pressure indicator 700 include body 702, from body 702 extend conduit 704, Entrance 705 and outlet 703, the piston type positioned at the plug 706 along conduit 704, the end positioned at conduit 704 to conduit 704 Piezometer 708 and pressure stability aperture 707.As illustrated, piezometer 708 be placed with respect to OPEP device 300 so that During treating, indicator and labelling are visible for the user of caregiver and/or OPEP device 300.

Similar with pressure indicator 600, pressure indicator 700 also includes check valve 784 in body 702 and from this The thorn 712 in the suction port 711 of OPEP device 300 is extended in body 702.Check valve 784 is configured to when in OPEP device Open during air-breathing at 300 mouthpiece 309, and close when when venting one's pent-up feelings.Thorn 712 is configured to be maintained at check valve 384 to be opened Position, thus makes body 702 be in fluid communication with mouthpiece 709.

In operation, pressure indicator 700 is configured to be operated with above-mentioned pressure indicator 400 identical mode, and And provide and the pressure indicator 400 identical visual feedback being connected on the mouthpiece 309 of OPEP device 300.

5th embodiment

As described above with pressure indicator 400 instruction, pressure stability aperture can be located between body and piezometer along conduit Any position, for example, as seen in Figure 56 F, or be located at the conduit extending in piezometer partly in, or be located at Formed in the passage of part of instruments for pressure measurement, for example, as seen in Figure 56 G.It should also be understood that one or Multiple pressure stability apertures can be located in piezometer, for example, at manometric porch, manometric blow vent, or entrance and At blow vent, with the vibration of the pressure measured by damped pressure gauge.

Turn to Figure 64 A, a diagram is provided, show piezometer 408 ', for example, be derived from the Ambu A/S of Copenhagen, Denmark The AMBU Disposable Pressure Manometer of company.Usually, piezometer 408 ' includes chamber 490, air enters Mouth 491, the one or more openings forming blow vent 492 and therebetween film 493.Chamber 490 is divided into two by film 493 Individual, produce the side of pressure being exposed to obtained in OPEP device and the side being exposed to atmospheric pressure.When air passes through Entrance 491, when OPEP device flows into chamber, increases in OPEP side upward pressure in chamber 490, causes film 493 to expand and pass through QI KOU 492 discharges the air that chamber 490 is exposed to the side of atmospheric pressure.As shown in Figure 64 A, a diameter of 3mm of entrance 491, and And area of section is 7.1mm², and blow vent 492 includes total cross-sectional area for 33mm²Four rectangular apertures（4.6mm taking advantage of 1.8mm）.

As shown in Figure 64 B, one or more pressure stability apertures can be located in piezometer 408 ', entering in piezometer 408 ' At mouth 491, at the blow vent 492 of piezometer 408 ', or at entrance 491 and blow vent 492.For example, at entrance 491 The diameter in pressure stability aperture 494 can be 0.6mm to 0.9mm, or area of section is in 0.283mm²And 0.636mm²Between.Pressure Power is stablized aperture 495 and be may be alternatively located at blow vent 492, and this blow vent includes four rectangular apertures as shown in Figure 64 B.Be located at The area of section in the pressure stability aperture 494 at entrance 491 is similar to, and forms the pressure stability aperture 495 being located at blow vent 492 The total cross-sectional area of opening scope in 0.283mm²And 0.636mm²Between.As indicated on, pressure stability aperture can position At entrance 491, at blow vent 492, or at entrance 491 and blow vent 492.Pass through entrance feed pressure meter by limiting 408 ', or pass through the air stream of blow vent 492 outflow pressure meter 408 ', measured by pressure stability aperture damped pressure gauge 408 ' The vibration of pressure, by the readable stress level of this allowable pressure indicator for displaying, and provides dynamic vision feedback simultaneously, allows and make User knows that OPEP device works.

Similarly, turn to Figure 65 A, a diagram is provided, shows piezometer 508 ', for example, be derived from Florida State gram Lille The MERCURY MEDICAL Disposable Pressure Manometer of the Mercury Medical company of water.One As, piezometer 508 ' includes chamber 590, air intake 591, forms one or more openings of blow vent 592 and be located at it Between film 593.Chamber 590 is divided into two by film 593, produces and is exposed to the side of pressure obtained in OPEP device and sudden and violent It is exposed to the side of atmospheric pressure.When air passes through entrance 591 when OPEP device flows into chamber, in chamber 590 on OPEP side Pressure increases, and causes film 593 to expand and passes through blow vent 592 and discharges the air that chamber 590 is exposed to the side of atmospheric pressure.As figure Shown in 65A, a diameter of 2.45mm of entrance 591, and blow vent 492 is made up of two openings that each diameter is 2mm.

As shown in Figure 65 B, one or more pressure stability apertures can be located in piezometer 508 ', entering in piezometer 508 ' At mouth 591, at the blow vent 592 of piezometer 508 ', or at entrance 591 and blow vent 592.For example, at entrance 591 The diameter in pressure stability aperture 594 can be 0.6mm to 0.9mm, or area of section is in 0.283mm²And 0.636mm²Between.Pressure Power is stablized aperture 595 and be may be alternatively located at blow vent 592, and this blow vent includes two openings as shown in Figure 65 B.With positioned at entrance The area of section in the pressure stability aperture 594 at 591 is similar to, and forms opening of the pressure stability aperture 595 being located at blow vent 592 The scope of the total cross-sectional area of mouth is in 0.283mm²And 0.636mm²Between.As indicated on, pressure stability aperture can be located at into At mouth 591, at blow vent 592, or at entrance 591 and blow vent 592.By limiting by entrance feed pressure meter 508 ' or By the air stream of blow vent 4592 outflow pressure meter 58 ', the pressure measured by pressure stability aperture damped pressure gauge 508 ' Vibration, by the readable stress level of this allowable pressure indicator for displaying, and provides dynamic vision feedback simultaneously, allows user to know Road OPEP device works.

Extra embodiment

As previously indicated, pressure indicator embodiment described herein can be used together with other OPEP devices, including for example： From the ACAPELLA OPEP device 810 of the Smiths Medical company of St. Paul, MN, as Figure 66-67 institute Show；From the FLUTTER OPEP device 820 of the Axcan Scandipharm Inc. company of Birmingham, Alabama, such as Shown in Figure 68-69；And the RC-CORONET OPEP device 830 of the Curaplex company from Ohio Dublin, such as Shown in Figure 70-71.

Arrange and use limited features

Turn to Figure 72-74, show another embodiment of pressure indicator 400 '.In addition to indicated as follows, pressure Indicator 400 ' is identical with above-mentioned pressure indicator 400 in other respects, and is configured to identical with pressure indicator 400 Mode operate, and provide and pressure indicator 400 identical visual feedback.

Figure 72 is the axonometric chart of the alternate embodiment of pressure indicator 400 ', is illustrated do not there is piezometer, it includes Stop unplanned setting and by using the feature being limited to approved respiratory therapy apparatus.Figure 73 is pressure indicator 400 ' unplanned be arranged on the OPEP device 300 of Figure 35 during different axonometric charts, illustrate with piezometer 408 '.Figure 74 is to be arranged on approved respiratory therapy apparatus（Such as OPEP device 300）The side-looking of pressure indicator 400 ' after upper Figure.

Usually, similar with pressure indicator 400, and as shown in Figure 72, pressure indicator 400 ' include body 402 ', from Conduit 404 ' and the plug 406 ' being located at along conduit 404 ' and being inserted that body 402 ' extends.Although not showing in Figure 72 Go out, but pressure indicator 400 ' also includes positioned at the outlet 403 ' place of conduit 404 ' being in piezometer 408 ' form for measuring The instrument of pressure, as shown in Figure 73-74.Body 402 ' can be dimensioned and be shaped to integrate with existing OPEP device, for example, such as Shown in Figure 74, integrate with the mouthpiece 309 of OPEP device 300.In the present embodiment, body 402 ' include 22mm ISO taper sun/ Female connector, this adapter is formed and is sized to mouthpiece 309 with OPEP device 300 and OPEP device 300 connects in itself Connect.

As shown in Figure 72-73, pressure indicator 400 ' includes stoping the end positioned at housing 402 ' of unplanned setting Annular ring or flange 412 ', such as visible in Figure 73.Specifically, when user attempts along upside down or rightabout will be pressed When power indicator 400 ' is arranged on OPEP device 300, flange 412 ' contacts from prolonging that the housing 302 of OPEP device 300 extends Extending portion 350, thus stop the male/female adapter of corresponding 22mm ISO taper on pressure indicator 400 ' and OPEP device 300 Connection.As visible in Figure 74, flange 402 ' do not stop corresponding 22mm ISO taper sun on pressure indicator 400 '/ The connection of the mouthpiece 309 of female connector and OPEP device 300.In this way, prevention user edge upside down or rightabout will be pressed Power indicator 400 ' is arranged on OPEP device 300.

As shown in Figure 72 and 74, pressure indicator 400 ' also includes being located at the end of the housing 402 ' contrary with flange 412 ' The circle 414 ' at place, the use of pressure indicator 400 ' is limited to approved respiratory therapy apparatus by described circle 414 '.As Figure 74 Shown, approved respiratory therapy apparatus can be OPEP device 300.Specifically, when user attempts will press along plan direction When power indicator 400 ' is arranged on OPEP device 300, the specific profile 415 ' of circle on pressure indicator 400 ' 414 ' with The respective specific profile 352 of the circle 354 on OPEP device 300 aligns so that 22mm ISO taper on pressure indicator 400 ' Male/female adapter can be fully engaged with OPEP device 300 and complete to be connected.But, if user attempts pressure indicator 400 ' are arranged on and do not have on the respiratory therapy apparatus of contoured, and contoured plan and the pressure of this respiratory therapy apparatus refer to Show that the profile 415 ' of the circle 414 ' on device 400 ' is corresponding and receive this profile 415 ', then circle 414 will be likely to stop pressure The mode that the male/female adapter of 22mm ISO taper in indicator 400 ' is connected with respiratory therapy apparatus contacts respiratory therapy dress Put.It should be understood that the respective specific profile 352 of the circle 354 of the contoured 415 ' of circle 414 ' and OPEP device is only exemplary , and can be with using other profiles any amount of or key pattern.In this way, the use of pressure indicator 400 ' can be limited It is formed on approved respiratory therapy apparatus, such as OPEP device 300.

Although providing described above under the background of OPEP device, for a person skilled in the art it is also apparent that It is that other respiratory therapy apparatus may also benefit from the various teachings comprising herein.Described above is to illustrate and describing purpose And propose, and plan is not exhaustive or limits the invention to disclosed precise forms.To art technology It is apparent that many changes and modifications can be carried out to the present invention in the range of following claims for personnel.

Claims

1. a kind of pressure indicator for respiratory therapy apparatus, described pressure indicator includes：

Instruments for pressure measurement；

Conduit, described conduit is configured to for the pressure in described respiratory therapy apparatus to be sent to described instrument；And

Pressure stability aperture in described conduit.

2. pressure indicator as claimed in claim 1, wherein, described instrument includes the passage connecting with described catheter fluid.

3. pressure indicator as claimed in claim 1, wherein, described respiratory therapy apparatus are oscillatory type PEP devices.

4. pressure indicator as claimed in claim 1, wherein, described instrument includes piezometer.

5. pressure indicator as claimed in claim 1, wherein, described pressure stability aperture has in 0.196mm²With 1.767mm²Between area of section.

6. pressure indicator as claimed in claim 1, wherein, described pressure stability aperture has in 0.283mm²With 0.636mm²Between area of section.

7. pressure indicator as claimed in claim 1, wherein, along the whole length of described conduit, described pressure stability aperture Area of section be less than described conduit area of section.

8. pressure indicator as claimed in claim 1, wherein, the part of described conduit extends in described instrument.

9. pressure indicator as claimed in claim 8, wherein, described pressure stability aperture extends to institute positioned at described conduit State described partly interior in instrument.

10. pressure indicator as claimed in claim 2, wherein, the part of described conduit extends in described passage.

11. pressure indicators as claimed in claim 2, wherein, described pressure stability aperture is located in described passage.

12. pressure indicators as claimed in claim 1, wherein, described pressure stability aperture is configured to damping and exhales from described Inhale the vibration that therapy equipment is sent to the pressure of described instrument.

13. pressure indicators as claimed in claim 11, wherein, described pressure stability aperture is configured to damping and exhales from described Inhale the vibration that therapy equipment is sent to the pressure of described instrument.

14. pressure indicators as claimed in claim 1, wherein, described instrument is included for for described respiratory therapy apparatus User provides vision or the indicator of auditory feedback.

15. pressure indicators as claimed in claim 1, wherein, described pressure indicator is connectable to described respiratory therapy The mouthpiece of device.

16. pressure indicators as claimed in claim 1, wherein, described pressure indicator can not block from described substantially The position of the air stream of the entrance to described conduit for the user of respiratory therapy apparatus is connected to described respiratory therapy apparatus.

17. pressure indicators as claimed in claim 1, wherein, described piezometer includes piston-type measurement device.

18. pressure indicators as claimed in claim 1, wherein, described piezometer includes rotating disc type quantifier.

19. pressure indicators as claimed in claim 14, wherein, described instrument can make described respiratory therapy apparatus User is during treating it can be seen that the position of described indicator is connected to described respiratory therapy apparatus.

A kind of 20. methods providing visual feedback during applying oscillatory type PEP therapy, methods described includes：

Receive discharge air stream in the porch of the conduit being connected with oscillatory type PEP device；

By limiting the discharge air stream by the described pressure stability aperture in described conduit, damp the discharge in described conduit The vibration of the pressure of air；

Measure pressure in the exit of described conduit；And

The instruction of the pressure in the measurement of the exit of described conduit is provided.

A kind of 21. pressure indicators for respiratory therapy apparatus, described pressure indicator includes：

Instruments for pressure measurement, described instrument includes chamber, is configured to receive the air from described respiratory therapy apparatus Stream chamber entrance and with described respiratory therapy apparatus around atmosphere chamber blow vent；And

Pressure stability aperture at least one of described chamber entrance or described chamber blow vent；

Wherein, the area of section in described pressure stability aperture is located therein less than described pressure stability aperture described entrance or The area of section of blow vent.

22. pressure indicators as claimed in claim 36, wherein, described instrument is piezometer.

23. pressure indicators as claimed in claim 36, also include the film in described chamber, and described film is configured to divide Described chamber, thus stop that the air stream flowing through described chamber entrance from described respiratory therapy apparatus passes through described chamber blow vent.

24. pressure indicators as claimed in claim 36, wherein, described chamber blow vent includes multiple openings.

25. pressure indicators as claimed in claim 39, wherein, described pressure stability aperture is included in described opening Multiple apertures.

26. pressure indicators as claimed in claim 36, wherein, described pressure stability aperture has in 0.196mm²With 1.767mm²Between area of section.