CN106456521A - Composition containing extract derived from green tea leafstalk for skin whitening - Google Patents
Composition containing extract derived from green tea leafstalk for skin whitening Download PDFInfo
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- CN106456521A CN106456521A CN201580008670.0A CN201580008670A CN106456521A CN 106456521 A CN106456521 A CN 106456521A CN 201580008670 A CN201580008670 A CN 201580008670A CN 106456521 A CN106456521 A CN 106456521A
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- green tea
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- petiole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
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- Mycology (AREA)
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- Epidemiology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a composition containing an extract derived from green tea leafstalks for skin whitening, wherein the composition is safe for the skin and simultaneously has excellent skin-whitening efficacy and high stability. Since the present invention uses green tea leafstalks, which are typically not used and discarded, the present invention has excellent value in terms of using waste resources. In addition, by containing the extract derived from green tea leafstalks, the composition of the present invention is safe for the skin, has high formulation stability, shows an excellent skin-whitening effect which reduces symptoms of pigmentation such as melasma and freckles, and reduces skin darkness and therefore leads to even and bright skin color.
Description
Technical field
The present invention relates to skin safe and have excellent skin whitening effects safe containing from green
The skin-whitening compositionss of the extract of Folium Camelliae sinensis handle.
Background technology
The colour of skin of people is according to the activeness manufacturing melanic melanocyte (melanocyte), the distribution of blood vessel, skin
The various factors such as skin thickness and the whether pigment containing carotenoid, bilirubin et al. inside and outside and determine.Particularly, black
Plain cell produces in the presence of the various enzymes such as tryrosinase (tyrosinase) and is called melanic black pigment, and this becomes
Key factor.The ring such as the melanic formation physiologic factor related to inherited genetic factorss, hormone secretion, pressure etc. and ultraviolet irradiation
The impact of border factor is relevant.It is known that the melanin being present in skin has the critical function protecting body from ultraviolet etc.,
But melanin produces excessively, the main cause promoting pigmentation, skin aging and inducing skin carcinoma will be become.In order to control
Treat or mitigate skin pigmentation disorder calmness symptom and the excessive melanin pigmentation being exposed to the generations such as ultraviolet, in the past, people will
Ascorbic acid (ascorbic acid), kojic acid (kojic acid), arbutin (arbutin), hydroquinone (hydroquinone),
Glutathione (glutathione) or these derivants, there is material hindering tyrosinase activity etc. it is used in mixed way and changing
In cosmetic or pharmaceuticals, but these materials exist that whitening effect is insufficient, the safety issue to skin and being mixed in
Stability problem in dosage form when in cosmetic etc., therefore it is using limited.
Content of the invention
The inventors discovered that, the extract of the green tea petiole not using in the past and throwing away is non-stimulated to skin and has excellent
Skin whitening effects, thus complete the present invention.
Therefore, it is an object of the invention to provide by using the extract from green tea petiole, obtaining excellent skin
The compositionss of whitening effect.
For reaching above-mentioned purpose, the present invention provide containing from green tea petiole extract as effective ingredient whitening
Use Dermatologic preparation composition.
By the present invention in that with the green tea petiole not using and throwing away in the past, having excellent in terms of waste resource recycling
Value.In addition, the compositionss of the present invention are due to containing the extract from green tea petiole, to skin safe and dosage form
Stability is high, shows excellent skin whitening effects, can reduce the pigmentation symptom such as nevuss, freckle, improves skin dimness, makes
The colour of skin is uniform and bright.
Brief description
Fig. 1 is the spectrogram of HPLC (high performance liquid chromatography) analysis result representing green tea petiole extract.
Specific embodiment
The compositionss of the present invention are by being used as effective ingredient containing green tea petiole extract, using the teaching of the invention it is possible to provide excellent skin is beautiful
White effect.
Green tea (Green tea) is the leaf generally utilizing Camellia sinensis (Camellia sinensis).Feature in the present invention
It is although not limiting species and the cultivation natural law of Camellia sinensis, but the use of position is petiole.In addition, leaf used in the present invention
Handle is to be dried or undried petiole.
Used in the present invention, the petiole of green tea is also referred to as base of leafPosition, the vascular bundle of petiole is used for even
Connect the vascular bundle of stem and the vascular bundle of blade, be in the past win leaf in Camellia sinensis after the position thrown away.But, the present inventor couple
The result that green tea petiole is analyzed, the composition species containing with green tea and content have very big difference, such that it is able to predict
Arrive very big with the difference on effect that green tea provides.
Further, since using in the past not using and the green tea petiole thrown away prepares extract from green tea petiole,
And use it for commodity, so can be used as functional material and the application product of high additive value, therefore the present invention is discarded
Resource reutilization aspect also has excellent value.
The extract deriving from green tea petiole used in the present invention can be prepared by means commonly known in the art, its
Method is not particularly limited, it is preferred to use the method for extracting the water soluble ingredient containing in green tea petiole.
Specifically, add hot water with respect to 5 times of green tea petiole weight in the green tea petiole being dried, specially plus
Enter the Purified Water that temperature is 80～90 DEG C, and extracted.Keep this temperature, heated and stirred 2 hours, and cool to room temperature, so
Only separate water soluble ingredient afterwards, and carry out filtering for the first time.Ethanol with respect to 2 times of filtrate gross weight is stirred while
It is added slowly to filtrate, removes the chlorophyll in supernatant, only collect precipitate hot air drying.During hot air drying keep 30～
40 DEG C, to prevent thermal denaturation.By such method, the extraction deriving from green tea petiole used in the present invention can be prepared
Thing.
By the extract from green tea petiole prepared by such method be, containing 0.90% catechin,
0.12% caffeine, the content of its constituent and the catechin containing 22.1%, the general green tea of 4.61% caffeine
Leaf extract is different, and the effect thus showing also differs.
In the compositionss of the present invention, can be with respect to composition total weight from the content of the extract of green tea petiole
0.001～20 weight %.When the content of the extract from green tea petiole is less than 0.001 with respect to composition total weight
During weight %, the performance of whitening effect is faint；And when its content is more than 20 weight %, skin irritation sense will be induced.
The compositionss of the present invention have excellent skin whitening effects, and high to skin safe, stability, therefore preferably exist
Utilize in industry.
The compositionss of the present invention can carry out dosage form as Dermatologic preparation composition, especially can serve as cosmetic combinations
Thing carries out dosage form, and can be containing the medium allowing on cosmeceutical or Dermatology or base during dosage form.In addition, this
The compositionss of invention can provide all dosage forms being applied to local, for example, it is possible to provide solution, oil phase are dispersed in and obtain in aqueous phase
Emulsion, suspension, solid, colloid, powder, mastic, foam (foam) or gas that emulsion, Aqueous dispersions obtain in oil phase are molten
The dosage form of glue composition.The compositionss of these dosage forms can be prepared by this area usual method.
Moreover, it relates to compositionss, in addition to the foregoing, do not damaging in the range of main efficacy results, excellent
Choosing can contain the other compositions that can improve main efficacy results.Additionally, compositionss according to the present invention contain wetting agent, soft further
Agent, UV absorbent, preservative, antibacterial, antioxidant, PH regulator, organic and inorganic pigment, spice, cool agent
Or antiperspirant.The combined amount of mentioned component is not damage in the range of the purpose of the present invention and effect, those skilled in the art can
Easily select, its combined amount can be 0.01～5 weight % with respect to composition total weight, specifically, can be 0.01～3
Weight %.
Additionally, the compositionss of the present invention can carry out dosage form as pharmaceutical compositions.When compositionss according to the present invention make
During for pharmaceuticals, conventional inorganic or organic carrier is added in effective ingredient used in the present invention, dosage form chemical conversion is solid
The oral agents of body, semisolid or liquid form or parenteral dose, and above-mentioned pharmaceutical compositions according to the present invention can pass through
Oral, parenteral, rectum, locally, percutaneous, intravenouss, intramuscular, intraperitoneal, subcutaneous etc. offerd medicine.
As above-mentioned peroral dosage form, tablet, pill, granule, capsule, powder, granula subtilises, powder, milkiness can be enumerated
Liquid, syrup, candy pill etc..In addition, as above-mentioned non-oral dosage forms, can enumerate injection, point drop, ointment, Emulsion, spray,
Suspending agent, oil preparation, suppositoryDeng.Compositionss according to the present invention utilize usual method, can be by easy for effective ingredient agent
Type, and now can be suitably using surfactant, excipient, coloring agent, spice, antistaling agent, stabilizer, buffer agent, outstanding
Turbid dose and other conventional adjuvant.
The input consumption of the effective ingredient of pharmaceutical compositions of the present invention is, according to being given age of object, sex, body
Weight, pathological state and its order of severity, give the judgement of approach or diagnosis person and different.Determine that it is suitable according to these factors
Consumption is in the horizontal extent of those skilled in the art, and it is such as 0.1mg/kg/ day to 100mg/kg/ day that one sky puts into consumption, more
Specifically 5mg/kg/ day is to 50mg/kg/ day, but does not limit here.
Further describe the present invention below by embodiment.These embodiments are used for the purpose of illustrating this
Bright, the personnel in the art with usual knowledge understand that the scope of the present invention is not limited to these embodiments naturally.
Embodiment 1：Preparation is from the extract of green tea petiole
In the green tea petiole being dried (at purchase：Villa garden Co., Ltd.) in, with 5 times of weight ratios of green tea petiole
Amount to add temperature be 80～90 DEG C of Purified Water, keeping temperature, two hours of one side heated and stirred.Cool to room temperature
Afterwards, only separate water soluble ingredient, carry out the using Japanese filter paper Adventec No.131 (Adventec MFS, Inc., Japan)
Once filter.The ethanol of 2 times amount with respect to filtrate gross weight being stirred while being added slowly to filtrate, removing supernatant
Chlorophyll, only collect precipitate, keep 30～40 DEG C of temperature, one side hot air drying, obtain the next of white powder
Come from the extract (yield of green tea petiole：1～3%).
Comparative example 1：Prepare green tea leaf extract
In love jasmine Pacific Ocean snow green tea manufacturer, in the secondary leaf tea of YULU, with the amount of 5 times of weight ratios of green tea
Add the Purified Water that temperature is 80～90 DEG C, keeping temperature, one side heated and stirred 2 hours.After cooling to room temperature, only separate
Water soluble ingredient, carries out filtering for the first time using Japanese filter paper Adventec No.131 (Adventec MFS, Inc., Japan).
After filtration, concentrated using vacuum distillation apparatus, be then dried using freeze-drying apparatus, obtained the green of yellowish-brown powder
Folium Camelliae sinensis extract.
Test example 1：The composition that quantitative analyses are extracted from green tea petiole
In order to confirm the composition containing in green tea petiole, HPLC is carried out to the green tea petiole extract of preparation in embodiment 1
Analysis, its result is as shown in figure 1 and table 1.
Used in experiment, chromatograph of liquid is the Alliance 2695 of Waters (Waters company), is by this
The system that chromatograph of liquid and 2996 photodiode array ultraviolet-visible spectrophotometers (PDA) combine.Chromatographic column is using fertile
The Symmetry C18 post (4.6mm × 7.5cm, 3.5 μm) of Te Si company (Waters company), data processing be using water this
The Empower II program of company (Waters company).Injection rate (injection volume) is 20.00 μ l.
Table 1
(C：Catechin, GC：Nutgall catechin, CG：Catechin and gallate, GCG：Nutgall catechin Galla Turcica (Galla Helepensis)
Acid esters, EC：Epicatechin, EGC：Epigallo catechin, ECG：L-Epicatechin gallate, EGCG：Epi-nutgall catechu
Plain epicatechol gallate, CAF：Caffeine)
The peak area percent (%Area) of each constituent of above-mentioned table 1 refers to the area of the chromatograph that Fig. 1 represents, its area
Content with composition is more and bigger.By comparing the area ratio of each composition with standard area, quantitative green tea petiole carries
Take the composition of thing, its result can confirm that in green tea petiole extract containing 0.90% total catechins and 0.12% caffeine.
Test example 2：Evaluate melanin using melanoma-a (Melan-a) cell and generate rejection ability
The melanin of the extract from green tea petiole obtaining in above-described embodiment 1 is generated inhibition and contrast
The extract from green tea obtaining in example 1 and the melanin life of the arbutin as known skin-whitening material
Inhibition is become to compare and evaluate.Cell employs the normal epidermis from inbred C57BL mouse embryo
Melanoma-a the cell of melanoblast.
On 48 orifice plates, with 1.5 × 104After cell number/hole is inoculated, cultivate 24 hours.Culture 24 hours after and training
After supporting 4 days, processed with substances.As substances used herein, employ above-described embodiment 1 and comparative example
The extract obtaining in 1 is dissolved in the solution of dimethyl sulfoxide (DMSO), and arbutin is dissolved in water by arbutin
The experimental concentration that 1% solution is diluted to the substances as shown in table 2 below to be used in culture medium.In addition, in order to than
Relatively, contrast group does not carry out the process of any substances.
After being processed with substances, remove culture medium, using Du Shi phosphate buffer (DPBS) washed cell, lead to
Cross tapping (tapping) to remove.Then, 2N sodium hydroxide (NaOH) solution of 100 μ l will be separately added into, in incubator
In carry out the culture of 1 hour.The cell solute of 90 μ l is transferred on 96 orifice plates, using the micro- disk analyser of ferment immunity
(ELISA Reader) (U.S. uncle rises multi-function microplate reader, Synergy 2, BIOTEK, USA) measures the absorbance of 475nm.
In addition, drenching formic acid (BCA) detection method using two quinolines, quantitation is carried out to protein.10 μ l/ hole reagent add respectively
Two quinolines entering 200 μ l drench formic acid (BCA, Bicinchoninic acid) solution (a liquid：Thermo 23228, b liquid：PIERCE
1859078), after, place in incubator 30 minutes, then measure the absorbance of 560nm.
Its result is as described in Table 2, by following mathematical expressions 1, by the melanic amount of contrast group with use trier
The ratio of the melanic amount after matter process, calculated with percentage rate.In addition, melanin amount now is the use of utilization
The protein modified values that the result being measured with above-mentioned BCA method is modified.
Mathematical expression 1
Table 2
| Substances | Melanin amount (%) |
| Contrast group's (no additives) | 100 |
| Embodiment 1 (3.12ppm) | 83.1 |
| Embodiment 1 (6.25ppm) | 78.4 |
| Embodiment 1 (12.5ppm) | 73.9 |
| Embodiment 1 (25ppm) | 68.3 |
| Comparative example 1 (25ppm) | 97.6 |
| Arbutin (25ppm) | 73.5 |
Knowable to above-mentioned table 2, in the case of the comparative example 1 with green tea extract-treated, melanic amount does not almost have
It is reduced, and in the situation with green tea petiole extract-treated, is processed using very low amount, also can reduce melanic
Amount.And, when the concentration with being more below arbutin concentration for the treatment of is processed, the melanin with arbutin same degree also can be obtained
Minimizing effect；When being processed with equal amount, obtain more excellent melanin minimizing effect.
As can be seen here, green tea petiole extract has the performances different from green tea leaf extract, can be used as very excellent
Skin-whitening material.
Test example 3：The evaluation of skin stability
The extract of green tea petiole is derived to observe to skin irritant situation, it is right to have carried out used in the present invention
The direct irritant test of human body skin.
Test carries out twice, is with healthy adult female 34, male 6 40 (mean aves altogether for the first time
35.1 years old) tested as subjects；It is with women 28, male 2 30 (mean aves 30.1 altogether for the second time
Year) tested as subjects.
Specifically, the extract from green tea petiole obtaining in above-described embodiment 1 is dissolved in water, makes
The solution of 10% concentration, by its solution with 20mg/cm2Amount even application on skin of back.
After coating, adhere to patch at this position, remove patch after 24 hours, then implement for the first time after 30 minutes
Read, implement second after 24 hours and read, be considered as confirming effect with last reading.In order to observe reagent, skin is pierced
Sharp intensity, the situation of the positive reaction according to skin, give weight (p- ,+, ++, +++, ++++on give 0,1 respectively,
2,3,4 numerical value), obtain the average response degree of skin.When average response degree is more than 1, it is judged as stimulating display positive.Tool
The criterion of body is as described in Table 3.In addition, the calculating of skin average response degree is to be carried out by following mathematical expressions 2, its knot
Fruit criterion is as shown in table 4.
Table 3
Criterion
| Reaction | Weight | Criterion | |
| - | 0 | ： | Reactionless |
| + | 1 | ： | Faint erythema |
| ++ | 2 | ： | The weak erythema of sharpness of border, edema and pimple |
| +++ | 3 | ： | Significantly erythema, pimple and blister |
| ++++ | 4 | ： | Big blister |
Mathematical expression 2
Table 4
Result criterion
| Skin average response degree | Criterion |
| 0.0～0.9 1.0～2.9 3.0～more than 4.9 5.0 | Non-stimulated subexcite moderate stimulation strong stimulation |
Measurement result is, using the skin average response degree after the extract of green tea petiole be 0.0～0.9 it
Between, therefore finally it is judged as non-stimulated to skin.
Illustrate that the dosage form example of compositionss according to the present invention, pharmaceutical compositions and cosmetic composition can adopt below many
Plant dosage form, but the present invention does not limit here, being intended merely to illustrate.
Dosage form example 1：Toner/smoothing toner (cosmetic water)
With the composition described in table 5 below, using usual method, prepare toner/smoothing toner.
Table 5
Dosage form example 2：Nutrition astringent (emulsion)
With the composition described in table 6 below, using usual method, prepare nutrition astringent.
Table 6
Dosage form example 3：Nourishing cream
With the composition described in table 7 below, using usual method, prepare nourishing cream.
Table 7
| Blending constituent | Content (weight %) |
| The extract from green tea petiole of embodiment 1 | 2.0 |
| Glycerol | 3.0 |
| Butanediol | 3.0 |
| Liquid Paraffin | 7.0 |
| Beta glucan | 7.0 |
| Carbomer | 0.1 |
| Caprylic/capric triglyceride | 3.0 |
| Squalane | 5.0 |
| Cetearyl glucoside | 1.5 |
| Span60 | 0.4 |
| Polysorbate60 | 1.2 |
| Triethanolamine | 0.1 |
| Preservative, pigment, spice | In right amount |
| Purified Water | Surpluses |
Dosage form example 4：Massage cream
With the composition described in table 8 below, using usual method, prepare massage cream.
Table 8
Dosage form example 5：Facial film
With the composition described in table 9 below, using usual method, prepare facial film.
Table 9
| Blending constituent | Content (weight %) |
| The extract from green tea petiole of embodiment 1 | 0.2 |
| Glycerol | 4.0 |
| Polyvinyl alcohol | 15.0 |
| Hyaluronic acid | 5.0 |
| Beta glucan | 7.0 |
| Allantoin | 0.1 |
| Nonylplenyl ether | 0.4 |
| Polysorbate80 | 1.2 |
| Ethanol preservative | 6.0 it is appropriate |
| Preservative, pigment, spice | In right amount |
| Purified Water | Surpluses |
Dosage form example 6：Ointment
With the composition described in table 10 below, using usual method, prepare ointment.
Table 10
| Blending constituent | Content (weight %) |
| The extract from green tea petiole of embodiment 1 | 0.2 |
| Glycerol | 8.0 |
| Butanediol | 4.0 |
| Liquid Paraffin | 15.0 |
| Beta glucan | 7.0 |
| Card ripple | 0.1 |
| Caprylic/capric triglyceride | 3.0 |
| Squalane | 1.0 |
| Cetearyl glucoside | 1.5 |
| Span60 | 0.4 |
| Cetearyl alcohol | 1.0 |
| Apis cerana Fabriciuss | 4.0 |
| Preservative, pigment, spice | In right amount |
| Purified Water | Surpluses |
As above in detail record present invention characteristic, for have the usual knowledge in this area technical staff,
These particular techniques are preferred implementation it is evident that the present invention does not limit here.Therefore, the essential scope of the present invention
It is define by claims and with this equipollent.
Claims (4)
1. a kind of Dermatologic preparation for beautifying compositionss are it is characterised in that described Dermatologic preparation for beautifying compositionss contain to come
The extract coming from green tea petiole is as effective ingredient.
2. Dermatologic preparation composition according to claim 1 it is characterised in that the content of described extract be with respect to
0.001～20 weight % of composition total weight.
3. Dermatologic preparation composition according to claim 1 is it is characterised in that the described extraction from green tea petiole
Water is extracted from green tea petiole as solvent and obtains by thing.
4. Dermatologic preparation composition according to claim 1 is it is characterised in that described compositionss suppress melanic life
Become.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20140021067 | 2014-02-24 | ||
| KR10-2014-0021067 | 2014-02-24 | ||
| PCT/KR2015/001775 WO2015126226A1 (en) | 2014-02-24 | 2015-02-24 | Composition containing extract derived from green tea leafstalk for skin whitening |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106456521A true CN106456521A (en) | 2017-02-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580008670.0A Pending CN106456521A (en) | 2014-02-24 | 2015-02-24 | Composition containing extract derived from green tea leafstalk for skin whitening |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR102322441B1 (en) |
| CN (1) | CN106456521A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111434333A (en) * | 2019-01-15 | 2020-07-21 | 株式会社爱茉莉太平洋 | Composition for skin whitening or preventing or improving skin wrinkles comprising green tea extract with modified amount of ingredients |
| CN113243437A (en) * | 2021-04-30 | 2021-08-13 | 浙江尖峰健康科技有限公司 | Plant source-based liquid beverage with whitening function and preparation method thereof |
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| CN102115467A (en) * | 2009-12-30 | 2011-07-06 | 温尧林 | Method for preparing catechin monomers |
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| KR101222677B1 (en) * | 2010-07-30 | 2013-01-22 | 주식회사 비티씨 | Composition for antioxidation, skin brightening and antiaging which comprises green tea hydrosate as an active ingredient |
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2015
- 2015-02-24 KR KR1020150025540A patent/KR102322441B1/en active IP Right Grant
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| CN1306419A (en) * | 1998-06-24 | 2001-08-01 | 科蒂股份有限公司 | Cosmetic preparation of active substrances with high protection factor against free radicals |
| CN101113147A (en) * | 2007-06-26 | 2008-01-30 | 朱江 | Method for tea by-product resource utilization |
| CN102115467A (en) * | 2009-12-30 | 2011-07-06 | 温尧林 | Method for preparing catechin monomers |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111434333A (en) * | 2019-01-15 | 2020-07-21 | 株式会社爱茉莉太平洋 | Composition for skin whitening or preventing or improving skin wrinkles comprising green tea extract with modified amount of ingredients |
| CN111434333B (en) * | 2019-01-15 | 2024-01-02 | 株式会社爱茉莉太平洋 | Composition for skin whitening or preventing or improving skin wrinkles comprising green tea extract having a modified amount of ingredients |
| US11896640B2 (en) | 2019-01-15 | 2024-02-13 | Amorepacific Corporation | Composition for skin-whitening or preventing or improving skin wrinkles comprising green tea extract which has modified amounts of ingredients |
| CN113243437A (en) * | 2021-04-30 | 2021-08-13 | 浙江尖峰健康科技有限公司 | Plant source-based liquid beverage with whitening function and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150100551A (en) | 2015-09-02 |
| KR102322441B1 (en) | 2021-11-09 |
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