CN106456037B - Biological signal measuring device - Google Patents
Biological signal measuring device Download PDFInfo
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- CN106456037B CN106456037B CN201580018958.6A CN201580018958A CN106456037B CN 106456037 B CN106456037 B CN 106456037B CN 201580018958 A CN201580018958 A CN 201580018958A CN 106456037 B CN106456037 B CN 106456037B
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- signal
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- bio signal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/30—Input circuits therefor
Abstract
Even if also can accurately extract the biological signal measuring device by correction signal control with the bio signal waveform of phase noise the present invention relates to occurring impedance unbalance between one kind electrode, it includes two channels for passing through two electrode detection human-body biological potentials；Equipped with carrying out the detector of differential operational after two groups of biopotentials that amplification is inputted by two channels respectively by differential operational device, and selectively adopts the output signal of two groups of detectors and obtain the bio signal extraction unit of bio signal；The amplifier magnifying power for being set to two groups of detectors is adjusted, to reduce the impedance corrector for the same phase noise power being entrained in from the bio signal that bio signal extraction unit obtains.
Description
Technical field
Even if also can accurately extract and be controlled by correction signal the present invention relates to occurring impedance unbalance between one kind electrode
With the biological signal measuring device of the bio signal waveform of phase noise.
Background technique
Bio signal is generated from the small electrical signals between human body cell, medical domain for confirm patient's states and
Myoelectricity state mainly has electrocardiogram, electromyogram, E.E.G etc..
As shown in Figure 1, including being contacted with that bio signal can be incuded for measuring the ECG tester of bio signal
Human body privileged site and two electrodes 10,20 for measuring biopotential；By the conducting wire 11,21 for being connected to electrode 10,20
It receives biopotential signals and differential operational is carried out to it and obtains the bio signal extraction unit 40 of bio signal；For storing,
The signal processing part 50 for the bio signal that analysis, Wireless transceiver or wired transmission are extracted.The ECG tester further includes
The reference electrode 30 for being contacted with human body privileged site except driven-right-leg circuit 60 and electrode for detecting biopotential, from
And it is applied to after extracting same phase noise from bio signal extraction unit 40 and being amplified by inverting amplifier Gr by conducting wire 31
Reference electrode 30.
By two electrodes 10,20 using the biopotential signals of two channel measurements as tiny organism signal and relatively large
Conjunction of the outside with phase noise signal.External noise signals are in-phase signal, can be detected simultaneously by two electrodes 10,20, therefore,
Bio signal can be obtained to control by the differential operational of bio signal extraction unit 40.
Representative same phase noise signal has the noise signal flowed by commonly using electricity Vs.For example, the common electricity of South Korea
Frequency be 60Hz, therefore, noise signal 60Hz, Europe commonly use electricity frequency be 50Hz, therefore, noise signal 50Hz.
Although one group of unit measuring device being made of two electrodes 10,20 is only shown in Fig. 1, but it is also possible to by more
Group unit measuring device is connected to multiplexer (MUX, multiplexer), and selectively specific unit measuring device
It is connected to bio signal extraction unit 40.Such as South Korea's 10-2012-0102444 publication, the measurement of multiple groups unit can use
Device extracts bio signal.
But when the impedance between electrode and human body changes and the impedance of two electrodes generation changes, far
Same phase noise much larger than bio signal to be measured is possible to be controlled by the differential operational of bio signal extraction unit 40
System.
That is, the same phase noise signal for being far longer than bio signal cannot lead to when impedance unbalance occurring between two electrodes
Differential operational is crossed to be adequately controlled, and with big signal residual, so that the accuracy of biological signal measuring be greatly reduced.
To solve the above-mentioned problems, detectable impedance unbalance is disclosed in Korean granted patent the 10-0868071st
Electrode impedance measurement method.
But due to physical activity, imbalance occurs at any time for impedance.Also, electrode is adhered to when using electrolyte gel
When human body, the hardenability of electrolyte gel also results in the imbalance of impedance.It is hindered for each impedance unbalance
Anti- balance, it is not only cumbersome, and inaccuracy.
[citation]
[patent document]
(patent document 1) KR 10-0868071B1 2008.11.04；
(patent document 2) KR10-2012-0102444A 2012.09.18.
Summary of the invention
The purpose of the present invention is making up the deficiencies in the prior art, there is impedance unbalance even if providing between one kind electrode,
Also signal processing can be carried out to the bio signal of electrode detection, the same phase noise of remnants caused by impedance unbalance is controlled, thus fast
Speed solves the problems, such as the biological signal measuring device generated by impedance unbalance.
In order to achieve the above object, The technical solution adopted by the invention is as follows:
Biological signal measuring device of the present invention includes two channels for passing through two electrode detection human-body biological potentials；It is equipped with
Two groups after amplifier amplifies the biopotential inputted by two channels respectively by the inspection of differential operational device progress differential operational
Device is surveyed, and selectively adopts the output signal of two groups of detectors and obtains the bio signal extraction unit of bio signal；Adjusting is set
It is placed in the amplifier magnifying power of two groups of detectors, is entrained in reduction same from the bio signal that bio signal extraction unit obtains
Phase noise power, thus control because between channel impedance unbalance due to the impedance corrector of same phase noise that is formed.
The impedance corrector selects two groups of detectors in turn, adjusts the amplifier magnifying power of selected detector until same phase
Noise is less than the same phase noise of unselected detector, when same phase noise power reaches the preset condition of convergence, by two groups of inspections
The output signal in device with the relatively small detector of phase noise is surveyed as bio signal.
Each channel is connected to the amplifier for being connected to differential operational device "+" input terminal in a detector, in another inspection
It surveys device and is connected to the amplifier for being connected to differential operational device "-" input terminal, the bio signal extraction unit includes to two groups of detections
The output signal of device carries out differential operational and obtains the differential operational portion of bio signal, and the impedance corrector is adjusted by channel point
It is not set to the amplifier magnifying power of two groups of detectors, so as to be doped in the bio signal obtained by the differential operational portion
Same phase noise power become smaller.
The beneficial effect of biological signal measuring device of the present invention is: logical in two for passing through two electrodes input biopotentials
Amplifier is respectively set in road, and reduces the power of same phase noise signal by the magnifying power of adjusting amplifier, to pass through two
Even if impedance unbalance occurs between two channels of a electrode, control can be also obtained with the bio signal of phase noise.
Also, when impedance unbalance between channel occurs, by being amplified before differential operational using amplifier
The signal processing of operation eliminates impedance unbalance, therefore, when measuring bio signal, even if make channel impedance because of physical activity
It constantly changes, can also cope with rapidly, to obtain accurate waveform bio signal.
It is controlled using amplifier of the present invention with same phase noise remaining after phase noise in addition, being eliminated by noise eliminator,
To can get more accurate bio signal.
Detailed description of the invention
Fig. 1 is the schematic diagram of existing biological signal measuring device.
Fig. 2 is the first embodiment schematic diagram of biological signal measuring device of the present invention.
Fig. 3 is the partial schematic diagram of Fig. 2.
Fig. 4 is the second embodiment schematic diagram of biological signal measuring device of the present invention.
Fig. 5 is the 3rd embodiment schematic diagram of biological signal measuring device of the present invention.
Fig. 6 is the fourth embodiment schematic diagram of biological signal measuring device of the present invention.
In figure, Z11, Z21: series impedance；Z12, Z22: parallel impedance；G1, G2, G3: differential operational amplifier；G11,
G12, G21, G22, G31, G32: amplifier；10,20: electrode；11,21: conducting wire；30: reference electrode；40: bio signal extracts
Portion's (prior art)；50, signal processing part；60: driven-right-leg circuit；100: bio signal extraction unit (present invention)；110,
120: pretreatment portion；130, differential operational portion；200: impedance corrector；210, power draw portion；220: gain adjustment portion；300:
Residual noise arrester；310: with phase noise extraction unit；320: power ratio extraction unit；330: with phase noise standardization portion；340:
Subtraction portion.
Specific embodiment
Highly preferred embodiment of the present invention is illustrated with reference to the accompanying drawing, so that those skilled in the art is easy to real
It applies.When describing the present invention, if influenced the detailed description of known function or known features to the clear of main points of the present invention
Clear description, then detailed description will be omitted.
Fig. 2 is the first embodiment schematic diagram of biological signal measuring device of the present invention.
As shown in Fig. 2, biological signal measuring device of the present invention includes at least two according to bio signal kind to be measured
The electrode 10,20 of class and specified mutually different privileged site detection human epidermal biopotential；For obtaining to by more
The biopotentials of two electrode detections selected in a electrode carries out differential operational and the life of the bio signal that controls same phase noise
Object signal extraction portion 100；And for storing, analyzing, the signal processing of wired transmission or the extracted bio signal of Wireless transceiver
Portion 50.
Further include two be set to the bio signal extraction unit 100, input for amplifying respectively by two electrodes
Amplifier G11, G12 of differential operational is carried out after biopotential, is doped in by the adjusting of the amplifier magnifying power to reduce
By bio signal extraction unit 100 extract bio signal in residual with phase noise signal power impedance corrector 200, into
The control of one step is by the control of impedance corrector 200 with the life still remained on after phase noise through the extraction of bio signal extraction unit 100
Same phase noise in object signal and the residual noise arrester 300 for being sent to signal processing part 50.
The multiple electrode 10,20 is usually the contact electrode that can be attached directly to human epidermal, passes through conducting wire 11,21
Electric signal mode is connected to the bio signal extraction unit 100.Although only showing that there are two electrode 10,20, measurements in attached drawing
At least three electrodes are used when electromyogram, electrocardiogram or E.E.G.
When using at least two electrodes, multiplexer (MUX, multiplexer) or switch can use by any electricity
Pole is selectively connected to bio signal extraction unit 100, can also configure multiple bio signal extraction units 100 and measure simultaneously more
A electrode signal.Its connection type is different according to the difference of biological signal measuring software.
As shown in Fig. 2, can add and be extracted from bio signal when noise signal Vs comes across human skin with same phase noise
It extracts with the driven-right-leg circuit 60 for carrying out reverse phase amplification after phase noise, and the reference electrode by being connected to conducting wire 31 in portion 100
30 feed back the same phase noise signal of reverse phase amplification in human body.
The signal processing part 50 can according to the mounting means (for example, human body wearing mode) of biological signal measuring device or
Deform setting in different forms using purpose.
The electrode 10,20, reference electrode 30, driven-right-leg circuit 60 and signal processing part 50 are well-known technique, about
Noise signal Vs, for example, point for the phenomenon that showing as same phase noise to the noise signal that there is the common electricity of certain frequency to generate
Analysis is also known, therefore simple detailed description herein.
3 couples of amplifier G11, G12 of the invention, impedance corrector 200 and residual noise arrester 300 with reference to the accompanying drawing
It is described in detail.
Fig. 3 is the detailed maps of Fig. 2.
As shown in figure 3, electrode 10,20 and conducting wire 11,21 in Fig. 3 in non-sign picture 2, and will comprising electrode 10,20 and
The constituent element of conducting wire 11,21 is denoted as electrical equivalent circuit.
That is, bio signal extraction unit 100 passes through two channel reception biologies being made of electrode 10,20 and conducting wire 11,21
Therefore electric potential signal is denoted as resulting from the input impedance in two channels.
By the input impedance that two channels show respectively include contact impedance between electrode 10,20 and human skin,
The impedance and carry out signal to before being input into bio signal extraction unit 100 by conducting wire received signal that conducting wire 11,12 generates
Impedance (not shown) of filter or amplifier (not shown) of processing etc..As shown in figure 3, can simplify into series connection impedance Z 11,
Z12 and parallel impedance Z12, Z22 mark.Also, for the conducting wire 31 and reference electrode 30 for being connected to driven-right-leg circuit 60
Speech can also be indicated the output end of driven-right-leg circuit 60 with series impedance Z31 and parallel impedance Z32.
As described above, being influenced by the bio signal that electrode incudes by input impedance, being input into bio signal extraction unit
100, when the input impedance in two channels occurs uneven, the present invention can pass through amplifier G11, G12, impedance corrector 200
And residual noise arrester 300 releases the influence of uneven generation.
The amplifier that described amplifier G11, G12 adjust magnifying power by that can pass through impedance corrector 200 is constituted, and is connected respectively
It is connected to and carries out (+) input terminal and the (-) input of the differential operational element G1 of differential operational in the bio signal extraction unit 100
End, so that the biopotential signals inputted by two channels to be input into (+) input terminal and (-) of differential operational element G 1
Change magnifying power respectively before input terminal and amplifies.
For example, described amplifier G11, G12 can be changed by magnifying power with the direct current size for being applied to control terminal
Voltage controlled amplifier (VCA:voltage controlled amplifier) is constituted, and the impedance corrector 200 can incite somebody to action
Direct current for adjusting amplifier G11, G12 magnifying power is applied to the control terminal of described amplifier G11, G12.
Comparison is described as follows before and after described amplifier G11, G12 are set to bio signal extraction unit 100.
Firstly, being illustrated to before described amplifier G11, G12 is arranged.
The optimum state for extracting bio signal is input terminal series impedance Z11, the Z12 phase of bio signal extraction unit 100
Same, the identical impedance balance state of parallel impedance Z12, Z22.When impedance balance state, it is input into bio signal extraction unit 100
It is identical with the size of phase noise, so as to eliminate same phase noise by differential operational.
But human body has activity slightly, it also can be in series impedance Z11, Z12 according between electrode and human skin
The variation of contact resistance etc. and change and with different value impedance unbalance state.It is, even if initial stage measurement life
Impedance is in equilibrium state when object signal, still, due to the activity of human body, cannot maintain impedance balance state.Also, electrode and
Contact resistance, the characteristic error of element for constituting each channel between human skin etc. also result in the imbalance of impedance.
Influence caused by impedance unbalance with phase noise is as follows.
For ease of calculation, do not do plural calculating, and assume series impedance Z11, Z21 and parallel impedance Z12, Z22 by
Resistive composition or capacitor composition are constituted, and, it is assumed that under impedance balance state, series impedance Z11, Z12 is 100 Ω, parallel connection
Impedance Z 11, Z21 are 1000 Ω, the magnifying power of differential operational amplifier G1 is 1000 times.The bio signal that human body is generated is assumed
When for 1mV, it can almost reach the hundreds times to thousands of times of bio signal with phase noise, therefore, as one embodiment of the invention
It is 1000mV by human-body biological signal hypothesis.When a certain series impedance Z21, which is in 100 Ω, becomes the non-equilibrium state of 110 Ω,
Measure the residue signal doped with big value as shown in Table 1 with phase noise.
Table 1
As shown in table 1, it when a certain series impedance Z21 increases by 10% and is in impedance unbalance state, flows into bio signal and mentions
The size of the same phase noise in portion 100 is taken also to change.If with this number carry out differential operational if, 1V(1000mV) life
Doped with the same phase noise of 8190mV in object signal, it is, the same phase noise generated is more much larger than bio signal.Finally, by
The difference of small impedance between channel and the waveform that bio signal cannot be obtained.
In contrast, in the embodiment of the present invention, differential operational is carried out for amplifying in the setting of bio signal extraction unit 100
Described amplifier G11, G12 of the signal inputted before by each channel, and carried out by the fine tuning of a certain amplifier G12 gain
When amplification, the signal that same phase noise as shown in Table 2 is controlled can get, that is, bio signal to be measured shows prominent signal.
Table 2
As shown in table 2, it even at channel impedance non-equilibrium state, is carried out by the fine tuning of a certain amplifier G12 gain
Amplification, can also make the same phase noise in two channels for being input into differential operational amplifier G1 almost the same.Therefore, it is carried out after amplification
Differential operational and the about 1V(1000mV obtained) bio signal in waveform doped with 81.9mV with phase noise.It is, can
Obtain the signal waveform of the same phase noise substantially reduced doped with bio signal.
Here, only being adjusted to the gain of a certain amplifier G12 for the ease of contrast table 2 and table 1, but the present invention
Embodiment in, it is possible to increase when the gain of a certain amplifier G12, reduce the gain of another amplifier G11, make after differential operational
Bio signal out is almost without changed power, to control same phase noise.
It is adjusted by impedance corrector 200 and is set to bio signal extraction unit for make up interchannel impedance unbalance
100 amplifier G11, G12 magnifying power.
The impedance corrector 200 includes the letter obtained from the differential operational by the bio signal extraction unit 100
The power draw portion 210 with phase noise power is extracted in number；And fine tuning is set to the amplifier of the bio signal extraction unit 100
The variation with phase noise power is observed while G11, G12 magnifying power, and tracks the magnifying power for making same phase noise power become smaller, from
And adjust the gain adjustment portion 220 of amplifier G11, G11 magnifying power.
The gain adjustment portion 220 is subtracted with increasing the magnifying power of any one amplifier in two amplifiers G11, G12
The mode of another small amplifier magnifying power changes the magnifying power of two amplifiers G1, G12.
Adjusting amplifier G11, G12 magnifying power is the imbalance in order to make up interchannel impedance.Specifically, when adjusting
When saving magnifying power, the bio signal power of pre-acquired is preferably maintained in constant.Therefore, it shades while micro- increasing a certain magnifying power another
Magnifying power finds out the magnifying power that can reduce same phase noise power.At this point, originally increased magnification variable quantity, is then gradually reduced
Magnification change amount, with this re-adjustments magnifying power, until same phase noise power convergence be within preset value until.When
In the state of increasing a certain magnifying power, reducing another magnifying power when becoming larger with phase noise power, the direction of inverse change magnifying power
And find the magnifying power that same phase noise power can be made to become smaller.
The power output portion 210 can be by the power of same phase noise signal as common electric frequency content power.For this purpose,
The power output portion 210 is normal from extract in the signal that differential operational obtains by the bio signal extraction unit 100
Observed while electricity consumption frequency content power, the gain adjustment portion 220 finely tune described amplifier G11, G12 common electric frequency at
Divide power, and finds out the magnifying power for reducing common electric frequency content power.It flows into when this is because extracting bio signal by commonly using
Noise signal caused by electricity.For example, South Korea is using 60Hz ingredient as same phase noise, Europe is using 50Hz ingredient as same phase noise.
By for same phase noise reverse feedback is a in the reference electrode 30 or third of the driven-right-leg circuit 60 of human body
After the same phase noise signal for being artificially induced human body is applied to human body by electrode, observation is adjusted with phase noise signal accordingly
The magnifying power of described amplifier G11, G12.
The same phase noise signal of the intention can be applicable in the signal of the names kind form such as specific frequency or AD HOC.Work as meaning
When the same phase noise signal of figure is specific frequency, is extracted by the frequency modulation of such as FFT or extracted using filter；And it anticipates
When the same phase noise signal of figure is AD HOC, then it is big noise to be extracted using correlation analysis (correlation analysis) method
It is monitored after small.
In order to which using the same phase noise signal of the intention, setting presets the specific frequency of frequency band for generating user
Rate signal or user preset the signal generator (not shown) of the AD HOC signal of mode and for signal is raw
The signal of generation of growing up to be a useful person is applied to the reference electrode 30 or third electrode of human body.
When set specific frequency signal is applied to human body, the power output portion 210 is extracted from by the bio signal
Portion 100 carries out extracting the preset band signal power, the gain adjustment portion 220 in the signal that differential operational obtains
The preset band signal power is checked while finely tuning amplifier G11, G12 magnifying power, institute can be reduced by finding out
State the magnifying power of preset band signal power.
When AD HOC signal is applied to human body, AD HOC signal is incuded by electrode and is mentioned by bio signal
It is exported after taking portion 100 to carry out signal processing.Therefore, the calculating of the power draw portion 210 bio signal extraction unit 100 carries out differential
Related figure between signal that operation obtains and the AD HOC signal for being applied to human body, the gain adjustment portion 220 are micro-
The magnifying power of described amplifier G11, G12 are adjusted, and observes the end value of related figure and finds out the magnifying power that can reduce related figure.It adjusts
Magnifying power is saved to reduce related figure and reduce noise power meaning having the same.
Special frequency band signal can not also be set to same phase noise, and adjust and extracted for reducing by the bio signal
Portion 100 carries out the magnifying power for the signal power that differential operational obtains.The method is applicable to that impedance is serious uneven and the life
Object signal extraction portion 100 carries out differential operational and show that the same phase noise signal in signal is far longer than the state of bio signal.That is,
When very big with phase noise signal, specific frequency can not also be extracted, and subtracts low power method part by adjusting magnifying power
Resolved impedance spectroscopy is uneven.
When the impedance corrector 200, the power ratio extraction unit 320 of residual noise arrester 300 and signal processing part 50
It is needed when being constituted with microprocessor using A/D converter (analog-to-digital converter) (not showing in Fig. 3).For
The magnifying power for adjusting by microprocessor described amplifier G11, G12, needs through D/A converter (dingital-to-
Analog converter) conversion magnifying power, the control terminal of described amplifier G11, G12 is input into after adjustment signal.For institute
The element for stating 100 differential operational of bio signal extraction unit can be made of differential operational amplifier, but can also be differential by carrying out
Operation and obtain digital signal A/D converter constitute.The A/D converter or D/A converter are well-known technique, are omitted herein
It is described in detail.
Even if amplifier G11, G12 are arranged in the bio signal extraction unit 100 for carrying out differential operational, and pass through impedance school
The magnifying power that positive device 200 adjusts amplifier G11, G12 carrys out same phase noise caused by impedance unbalance between control channel, still, together
Phase noise is also possible to be perfectly controlled and remain.That is, as shown in table 2, even if the amplification of vernier amplifier G11, G12
Rate also can substantially control same phase noise, however be difficult to fine adjustment amplifier.Therefore, to greatest extent by impedance corrector 200
After control residual in ground reaches preset residual with phase noise with phase noise, controlled using residual noise arrester 300
Remaining same phase noise.
The residual noise arrester 300 is extracted from the bio signal extraction unit 100 with phase noise signal, and is standardized
After being doped in the same phase noise power carried out in the signal that differential operational obtains by the bio signal extraction unit 100,
Subtract in the signal that differential operational obtains from by the bio signal extraction unit 100.With this, pass through the residual noise
The elimination of arrester 300 does not obtain controlling remaining same phase noise by two amplifiers G11, G12 and impedance corrector 200,
To obtain sufficiently control with the bio signal of phase noise.
The residual noise arrester 300 includes being added respectively by being set to the two of the bio signal extraction unit 100
The signal of a amplifier amplification and obtain the same phase noise extraction unit 310 of same phase noise signal, for obtaining same phase noise
The power of signal obtains the power ratio of the same phase noise power of signal to the differential operational by the bio signal extraction unit 100
Power ratio extraction unit 320, the same phase noise signal and the power ratio obtained that be multiplied and same mutually making an uproar for standardizing
Sound standardization portion 330 and the same phase noise of standardization is subtracted from the signal that 100 differential operational of bio signal extraction unit obtains
The subtraction portion 340 of signal.
Due to being added the signal amplified respectively by being set to two amplifiers of the bio signal extraction unit 100
In be also doped with noise signal other than bio signal or common electric frequency ingredient, therefore, the power ratio extraction unit 320 utilizes
The processor that the power draw portion 210 uses is from the signal and the biology obtained by the same phase noise extraction unit 310
Signal extraction portion 100 carries out differential operational and obtains the common electric frequency content power respectively in the signal that obtains, to obtain
The same phase noise power of power ratio must be used to obtain.
Preset band signal can also be applied on abiotic potential measurement electrode, and from passing through the same phase
The same phase noise signal and obtained by the bio signal extraction unit 100 progress differential operational that noise extraction unit 310 obtains
Signal in respectively obtain described in preset band component power, to obtain the power ratio.
Specific frequency (common electric frequency ingredient or described preset frequency) content power can pass through fast Flourier
Transformation (FFT:Fast Fourier Transform) extracts and obtains special frequency band power.
When AD HOC signal is applied to human body, calculating is applied to the AD HOC signal of human body and by the same phase
Correlation between the same phase noise signal that noise extraction unit 310 obtains is schemed, is applied to the AD HOC signal of human body and by described
Bio signal extraction unit 100 carry out differential operational and the signal that obtains between related figure after, with the ratio between the related figure calculated respectively
It is used instead of power ratio.
Restart the residual noise arrester 300 after first starting the impedance corrector 200, to control to the maximum extent
Make two channel impedances it is uneven caused by residual noise is controlled with after phase noise, and then obtain and sufficiently eliminate with mutually making an uproar
The bio signal waveform that acoustic streaming enters.
The second embodiment of the present invention, 3rd embodiment and fourth embodiment are illustrated below.
In of the invention second, third, fourth embodiment, two groups of detectors are parallel to two by bio signal extraction unit 100
A channel, the detector pass through for passing through the biopotential inputted by two channels after amplifier amplifies respectively
Differential operational device carries out differential operational, is provided only with a bio signal extraction unit 100 in first embodiment, still, second, third
It is equipped with two groups of bio signal extraction units 100:100-1,100-2 in embodiment, is equipped with two groups of pretreatment portions in fourth embodiment
110、120。
Also, the signal exported respectively can selectively be selected and be obtained same by being additionally provided on two groups of detectors
The device for the bio signal that phase noise is controlled.That is, including being carried out to two groups of detectors in second embodiment, 3rd embodiment
The selection device of a certain detector of final choice after selecting in turn, in fourth embodiment include two groups of detectors of selection and to output
The device of bio signal is handled and obtained in the signal of each detector.
Fig. 4 is the second embodiment schematic diagram of biological signal measuring device of the present invention.
As shown in figure 4, biological signal measuring device of the present invention includes two bio signal extraction units for being equipped with amplifier
100, the bio signal extraction unit 100 is by the first bio signal extraction unit 100-1 and the second bio signal extraction unit 100-2 structure
At the first bio signal extraction unit 100-1 and the second bio signal extraction unit 100-2 are parallel to two channels.
Also, the power draw portion 210 of impedance corrector 200 is biological from the first bio signal extraction unit 100-1 and second
Signal extraction portion 100-2 obtains the signal for carrying out differential operational respectively and obtains same phase noise power.
The gain adjustment portion 220 repeats following adjustment process, that is, adjusts two groups of bio signal extraction units 100:
When the magnifying power of a certain amplifier in 100-1,100-2 makes it be less than another same phase noise with phase noise, to adjust a certain put
The process of another amplifier magnifying power of status adjustment of big device magnifying power.When same phase noise power reaches preset convergence item
When part, selected to be sent to remnants from the bio signal that the small bio signal extraction unit of same phase noise power obtains with switch 230
Noise eliminator 300, the switch 230 can be made of multiplexer (MUX, multiplexer).
The preset condition of convergence can be same phase noise power decreasing to be less than preset value condition or
It is also slow because of the ratio to become smaller or the degree that becomes smaller with phase noise power even if person adjusts magnifying power, and can be less than in advance
The condition of the ratio of setting or the ratio of degree or degree.
Specific embodiment is as follows.
Firstly, in first bio signal extraction unit 100-1 amplifier G11, G12 magnifying power and the extraction of the second bio signal
The same phase noise power for carrying out differential operational in the state that 100-2 amplifier G21, G22 magnifying power in portion is identical and obtaining is compared
After relatively, selection flows into the bio signal extraction unit of smaller same phase noise.For example, if the first bio signal extraction unit 100-1
Smaller with phase noise, then changing the magnifying power of second bio signal extraction unit 100-2 amplifier G21, G22, observation is same mutually to make an uproar
Whether sound can become smaller and less than the same phase noise of the first bio signal extraction unit 100-1.The change of the magnifying power refers to increasing
The magnifying power of a certain amplifier in big amplifier G21, G22, and reduce the magnifying power of another amplifier.
Then, the magnifying power for changing second bio signal extraction unit 100-2 amplifier G21, G22, when same phase noise is less than
When the first bio signal extraction unit 100-1, changes the first bio signal in the state that the magnifying power of change is directly applicable in and extract
The magnifying power of portion 100-1 amplifier G11, G12, and whether observe with phase noise less than the second bio signal extraction unit 100-2.First
The magnifying power of first signal extraction portion 100-1 amplifier G11, G12 is adjusted to the second adjusted bio signal extraction unit
Change magnifying power after 100-2 amplifier G21, G22 magnifying power.Although this is can reflect relative to another amplifier
Its magnifying power and as change magnifying power starting point.
As described above, adjusting first bio signal extraction unit 100-1 amplifier G11, G12 in turn and the second bio signal mentions
During taking portion 100-2 amplifier G21, G22 if when reaching the preset condition of convergence, selected by switch 230
It selects and obtains what the relatively small a certain bio signal extraction unit of the same phase noise power of signal obtained by differential operational from being doped in
Bio signal.When impedance contrast changes, repeat the above process and heavy in two groups of bio signal extraction units by switch 230
Newly selected.
Residual noise arrester 300 includes receiving to pass through respectively in two groups of bio signal extraction units 100:100-1,100-2
The signal of amplifier amplification, and the multichannel of the signal for obtaining same phase noise signal is selected and is adopted as from received signal
Multiplexer (MUX, multiplexer) 350.Two groups of biology letters are selected since the impedance corrector 200 has passed through switch 230
Some in number extraction unit 100:100-1,100-2, therefore, multiplexer (MUX, the multiplexer) 350 is best
Signal, which is received, from the bio signal extraction unit selected by switch 230 obtains same phase noise signal.Then, using passing through multichannel
Signal enabling power ratio extraction unit 320 that multiplexer (MUX, multiplexer) 350 selects, with phase noise standardization portion 330 and
The process of subtraction portion 340 is identical as the first embodiment of the present invention, detailed description will be omitted.
In the embodiment of the present invention include driven-right-leg circuit 60, therefore, can from the multiplexer (MUX,
Multiplexer the same phase noise signal not fed back in human body) is obtained in the signal of 350 selections, another multichannel also can be set
Multiplexer (MUX, multiplexer) and the bio signal extraction unit selected from switch 230 receive signal and obtaining do not feed back in
The same phase noise signal of human body.
Fig. 5 is the 3rd embodiment schematic diagram of biological signal measuring device of the present invention.
As shown in figure 5, the 3rd embodiment of biological signal measuring device of the present invention is equipped with two groups of lifes such as second embodiment
Object signal extraction portion 100:100-1,100-2, and by impedance corrector 200 to two groups of bio signal extraction unit 100:100-1,
100-2 adjusts amplifier magnifying power in turn, and selects the bio signal extraction unit relatively small with phase noise.Unlike, with more
Path multiplexer 230 ' replaces the switch 230 in second embodiment to select bio signal extraction unit.
Residual noise arrester 300 do not include such as the same phase noise extraction unit 310 in first embodiment and second embodiment,
And the biology not selected by the multiplexer 230 ' in two groups of bio signal extraction units 100:100-1,100-2 is utilized to believe
Number extraction unit is obtained with phase noise signal.
Specifically, the gain adjustment portion 220 of impedance corrector 200 mentions two groups of bio signals such as second embodiment
Take portion 100:100-1,100-2 to amplify the adjusting of device magnifying power in turn, and select the preset condition of convergence similarly hereinafter
After the relatively small bio signal extraction unit of phase noise, one in two amplifiers of bio signal extraction unit not selected is controlled
And carry out reverse phase amplification or block amplified signal output (with magnifying power be 0 when it is identical).At this point, in non-selected biology
The signal that signal extraction portion carries out differential operational and obtains is the signal with phase noise dominance, that is, although doped with to be measured
Bio signal, but be far longer than bio signal with phase noise.
While the selection of multiplexer 230 ' is with phase noise small bio signal extraction unit, swaps and make not
The output of another bio signal extraction unit selected is sent to the same phase noise standardization portion 330 of residual noise arrester 300.
Power ratio extraction unit 320 calculates the signal for being output in two bio signal extraction units 100:100-1,100-2 respectively
In with phase noise frequency band power, and calculate to being doped in the defeated of bio signal extraction unit that the multiplexer 230 ' selects
The same phase noise band power of signal (between correction channel impedance unbalance and control the signal of same phase noise) is doped in not out
It is multiplexed the same of the bio signal extraction unit signal (signal for being far longer than bio signal with phase noise) of the selection of device 230 '
The power ratio of calculating is reflected in same phase noise standardization portion 330 by the ratio between phase noise band power.
The same phase noise to be standardized by same phase noise standardization portion 330, and remained on by the control of subtraction portion 340
Pass through the same phase noise for the bio signal extraction unit output signal that multiplexer 230 ' selects.3rd embodiment shown in fig. 5
In, it is power ratio extraction unit 320, identical as the first, second embodiment with phase noise standardization portion 330 and subtraction portion 340, it omits detailed
It describes in detail bright.
As shown in figure 5,3rd embodiment also includes driven-right-leg circuit 60, therefore, it is additionally provided with two groups of bio signals of selection
In extraction unit 100:100-1,100-2 any one and obtain the multiplexer 61 of same phase noise.
The 3rd embodiment is not provided with residual noise arrester 300 compared with second embodiment.It can certainly incite somebody to action
Impedance corrector 200 and residual noise arrester 300 are used as a microprocessor, to be used in being used for for power draw portion 210
The processor obtained with phase noise power is used in power ratio extraction unit 320.
Fig. 6 is the fourth embodiment schematic diagram of biological signal measuring device of the present invention.
As shown in fig. 6, bio signal extraction unit 100 includes being amplified respectively by amplifier by being made of electrode and conducting wire
Two channels ch1, ch2 input each channel biopotential signals after carry out differential operational and obtaining respectively carried out it is pre-
The first pretreatment portion 110 and the second pretreatment portion 120, the standardization power of the signal of processing make in 110 and of the first pretreatment portion
What the second pretreatment portion 120 obtained respectively carried out pretreated signal it is identical with phase noise power after, carry out differential operational
And control is obtained with the differential operational portion 130 of the bio signal of phase noise.
The correction simultaneously of impedance corrector 200 is respectively arranged at by the first pretreatment portion 110 and the second pretreatment portion 120
The amplifier magnifying power in the two groups of each channels of pretreatment portion constituted, and adjusting magnifying power is tracked, make to be doped in by described differential
The same phase noise power in bio signal that operational part 130 obtains becomes smaller.
First pretreatment portion 110 and the second pretreatment portion 120 are parallel to channel ch1, ch2, and channel is connected to
The differential operational device "+" input terminal of any one pretreatment portion, the differential operational device "-" input terminal of another pretreatment portion.
Specifically, being respectively arranged at differential operational device G1, G2 of the first pretreatment portion 110 and the second pretreatment portion 120
Differential operational is carried out to the signal for being input into "+" input terminal and "-" input terminal, a channel ch1 is connected to first
Pretreatment portion 110 and the second pretreatment portion 120 are connected to differential operational device G1 by amplifier G11 in the first pretreatment portion 110
"+" input terminal, the "-" input terminal of differential operational device G2 is connected to by amplifier G22 in the second pretreatment portion 120.
Another channel ch2 diverges and passes through amplifier respectively in the first pretreatment portion 110 and the second pretreatment portion 120 and connect
It is connected to another input terminal of differential operational device.That is, another channel ch2 is connected in the first pretreatment portion 110 by amplifier G12
The "-" input terminal of differential operational device G1 is connected to the "+" of differential operational device G2 in the second pretreatment portion 120 by amplifier G21
Input terminal.
It is, being exchanged with each other the differential operational device G1 input terminal polarity of the first pretreatment portion 110 of input channel signal
With 120 differential operational device G2 input terminal polarity of the second pretreatment portion.
As described above, the first pretreatment portion 110 and the second pretreatment portion 120 are connected to channel ch1, ch2, and pass through two
The same phase noise ingredient in biopotential signals that a channel ch1, ch2 are flowed into is by the first pretreatment portion 110 and the second pre- place
When reason portion 120, pretreated noise contribution is carried out by the first pretreatment portion 110 and is carried out by the second pretreatment portion 120 pre-
The noise contribution of processing can become reverse phase or same phase according to the magnifying power of amplifier G11, G12, G21, G22.
But any one polarity in differential operational device G1, G2 input terminal polarity is preassigned, it is connected to specified pole
Property input terminal amplifier magnifying power and be connected to another polar amplifier magnifying power ratio be greater than the same phase noise of interchannel
When power ratio, it is doped in the noise contribution carried out in pretreated signal in the first pretreatment portion 110 and the second pretreatment portion 120
Signal becomes same phase.
As shown in fig. 6, amplifier G11 is to the magnifying power ratio of amplifier G12 and second in the first pretreatment portion 110
Amplifier G21 is greater than the magnifying power ratio of amplifier G22 and is made an uproar by the same phase that channel ch1, ch2 are flowed into pretreatment portion 120
When acoustical signal power ratio, it is doped in and carries out making an uproar in pretreated signal in the first pretreatment portion 110 and the second pretreatment portion 120
Sound twocomponent signal becomes same phase.
At this point, being located in advance by differential operational portion 130 to by the first pretreatment portion 110 and the second pretreatment portion 120
The signal of reason carries out differential operational to control same phase noise signal.
The impedance corrector 200 is when the amplifier magnifying power for adjusting the first pretreatment portion 110 and the second pretreatment portion 120
When making to become smaller in the signal obtained by the differential operational portion 130 with phase noise, the convergence of amplifier magnifying power makes it have control
System is the same as the ratio between the magnifying power of phase noise signal conditioning.
In the embodiment of the present invention, the first pretreatment portion 110 and the second pretreatment portion 120 are set in order to track rapidly
Amplifier magnifying power preassigns pretreatment portion 110, a certain polarity in 120 differential operational device input terminal polarity, and makes to connect
It is greater than in the amplifier magnifying power of specified polarity input terminal and is connected to another polar amplifier magnifying power, amplification is adjusted with this
Rate.Difference is set to specifically, being greater than in amplifier G11, G12 magnifying power for being set to differential operational device G1, G2 "+" input terminal
Rate is amplified while finely tuning magnifying power under conditions of amplifier G12, G22 magnifying power of dynamic arithmetic unit G1, G2 "-" input terminal
Tracking.
In contrast, during tracking magnifying power, the position according to the electrode 10,20 for obtaining bio signal is (attached
In the position of human body), even if pass through two channels ch1, ch2 flow into biopotential signals in reverse phase bio signal ingredient
Pretreated life is carried out by the first pretreatment portion 110 and the second pretreatment portion 120, that is, by the first pretreatment portion 110
Object signal component and to carry out pretreated bio signal ingredient by the second pretreatment portion be reverse phase.
Even if can not be to being doped in the signal obtained by pretreatment by the differential operational in differential operational portion 130
Reverse phase bio signal is controlled, and obtain has abundant powerful bio signal instead.
As shown in fig. 6, the differential operational portion 130 passes through amplifier G31, G32 to by the first pretreatment portion 110 respectively
And second pretreatment portion 120 pre-processed and the signal that obtains by differential operational device G3 carries out differential fortune after amplifying
It calculates, and adjusts the magnifying power of each amplifier G31, G32 by power normalization portion 131.
That is, the power normalization portion 131 is carried out from by first pretreatment portion 110 and the second pretreatment portion 120
It extracts in pretreated signal with phase noise twocomponent signal power, and adjusts the magnifying power of described amplifier G31, G32, so as to mix
It is miscellaneous in carrying out the same phase noise ingredient in pretreated signal by first pretreatment portion 110 and the second pretreatment portion 120
The power of signal is identical.The magnifying power of any one amplifier in two amplifiers G31, G32 can also be adjusted makes
It is identical with the power of phase noise twocomponent signal.
It is input into the same phase noise signal of the "+" input terminal of the differential operational device G3 and the signal of "-" input terminal respectively
Power is identical, therefore, the signal of same phase noise is controlled by the differential operational of the differential operational device G3, that is, can get control
Make the sufficiently big signal of same phase noise, bio signal.Error etc. can occur during extracting with phase noise power, therefore, together
The identical meaning of phase noise power can will sufficiently be controlled at required by the differential operational of the differential operational device G3 with phase noise
It is horizontal.
Adjust the first pretreatment portion 110 amplifier G11, G12 120 amplifier G21 of magnifying power and the second pretreatment portion,
The magnifying power of G22 makes to carry out what differential operational obtained by the differential operational portion 130 for being equipped with the power normalization portion 131
Same phase noise in signal is minimum, thus, control can be obtained impedance unbalance occurs with the bio signal of phase noise, and
Make same phase noise power in a disguised form with after using amplifier G31, the G32 that can pass through the adjusting of power normalization portion 131 magnifying power
Differential operational is carried out, what is actually obtained is the bio signal for eliminating same phase noise.It therefore, can in the fourth embodiment of the present invention
Not include the residual noise arrester 300 being equipped in the first, second, third embodiment of the invention.
The extraction of the same phase noise power for standardization in the power normalization portion 131 and the impedance corrector
The extraction of the 200 same phase noise power for magnifying power tracking can be by illustrating in the first, second, third embodiment of the invention
Common electric frequency content power extraction, apply to preset and preset mentioning for band signal power after the signal of frequency band
It takes and is applied to preset AD HOC signal in the extraction for presetting AD HOC signal power after human body
Any one is constituted.
When extracting preset AD HOC signal power, the impedance corrector 200, which adjusts magnifying power, makes related figure
Become smaller, such as the first embodiment of the present invention, second embodiment, 3rd embodiment, the differential operational portion 130 calculates pre- at two groups
The signal that processing unit 110,120 carries out differential operational respectively and obtains is schemed to the related of AD HOC signal is preset, thus
The magnifying power of amplifier G31, G32 are adjusted, so that related figure is identical.
Above-mentioned explanation is only the detailed description to the embodiment of the present invention, but the scope of the present invention be not limited to it is above-mentioned
Embodiment.Claims and specification and its it is shown in the drawings within the scope of by it is some modification, it can be achieved that different
Embodiment, and this modification should belong to the scope of the present invention.
Claims (8)
1. a kind of biological signal measuring device, it is characterised in that: pass through two electrode detection human-body biological potentials including two
Channel；Equipped with two groups through amplifier respectively amplify by two channels input biopotential after by differential operational device carry out it is differential
The detector of operation, and the bio signal selectively adopted the output signal of two groups of detectors and obtain bio signal extracts
Portion；The amplifier magnifying power for being set to two groups of detectors is adjusted, is entrained in the biology obtained from bio signal extraction unit to reduce
Same phase noise power in signal, thus control because between channel impedance unbalance due to the impedance correction of same phase noise that is formed
Device, the impedance corrector select two groups of detectors in turn, adjust the amplifier magnifying power of selected detector until same phase noise
Less than the same phase noise of unselected detector, when same phase noise power reaches the preset condition of convergence, by two groups of detectors
In with the relatively small detector of phase noise output signal as bio signal.
2. biological signal measuring device according to claim 1, it is characterised in that: the impedance corrector is adjusted by Selected Inspection
When surveying the amplifier magnifying power of device, it is first adjusted to the amplifier magnifying power of unselected detector, then starts to be adjusted.
3. biological signal measuring device according to claim 1, it is characterised in that: further include residual noise arrester, institute
Residual noise arrester is stated by two on any one detector in two groups of detectors for being set to the bio signal extraction unit
The input signal of a amplifier obtains after being added with phase noise signal, and the chemical conversion of the same phase noise specification of signals of acquisition is doped in
After the same phase noise power of the bio signal obtained by the bio signal extraction unit, from passing through the bio signal extraction unit
It is subtracted in the bio signal of acquisition and obtains the remaining bio signal with phase noise of control.
4. biological signal measuring device according to claim 3, it is characterised in that: after first starting the impedance corrector
Restart the residual noise arrester, to first control the same phase noise formed by interchannel impedance unbalance, then again
The remaining same phase noise of control.
5. biological signal measuring device according to claim 1, it is characterised in that: each channel is connected in a detector
It is connected to the amplifier of differential operational device "+" input terminal, is connected to that be connected to differential operational device "-" defeated in another detector
Enter the amplifier at end, the bio signal extraction unit includes carrying out differential operational to the output signal of two groups of detectors and obtaining life
The differential operational portion of object signal, the impedance corrector is adjusted to be amplified by the amplifier that channel is respectively arranged at two groups of detectors
Rate, so that the same phase noise power being doped in the bio signal obtained by the differential operational portion becomes smaller.
6. biological signal measuring device according to claim 5, it is characterised in that: the bio signal extraction unit it is differential
Operational part carries out differential operational after standardizing to the output signal of two groups of detectors, obtain bio signal, make to be doped in two
It is identical with phase noise power in the output signal of group detector.
7. biological signal measuring device according to claim 6, it is characterised in that: the impedance corrector, which is preset, to be set
A polarity being placed in the differential operational device input terminal polarity of detector adjusts the amplifier for being connected to specified polarity input terminal
Magnifying power is larger than the amplifier magnifying power for being connected to another polarity input terminal.
8. the biological signal measuring device according to claim 4 or 7, it is characterised in that: with phase noise power by common electricity
Frequency content power, the specific mould being pre-adjusted for presetting band signal power and being applied to human body for being applied to human body
A composition in formula signal power.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2015/004679 WO2016182093A1 (en) | 2015-05-11 | 2015-05-11 | Biosignal measurement device |
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| Publication Number | Publication Date |
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| CN106456037A CN106456037A (en) | 2017-02-22 |
| CN106456037B true CN106456037B (en) | 2019-07-12 |
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| CN201580018958.6A Expired - Fee Related CN106456037B (en) | 2015-05-11 | 2015-05-11 | Biological signal measuring device |
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| WO (1) | WO2016182093A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1581626A (en) * | 2003-08-05 | 2005-02-16 | 刘金生 | Anti interference method and device |
| KR20080109524A (en) * | 2007-06-13 | 2008-12-17 | 삼성전기주식회사 | Single input differential output type amplifier for multi-band |
| CN102386863A (en) * | 2010-09-02 | 2012-03-21 | 飞兆半导体公司 | Integrated circuit single ended-to-differential amplifier |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP3167319B2 (en) * | 1990-10-25 | 2001-05-21 | パイオニア株式会社 | Isolator circuit |
| JP2003235823A (en) * | 2002-02-15 | 2003-08-26 | Naohiro Toda | External ac noise eliminating system for biological electric signal |
| KR101674580B1 (en) * | 2010-03-26 | 2016-11-09 | 삼성전자주식회사 | Apparatus and method for measuring biological signal |
| KR101227413B1 (en) * | 2011-03-08 | 2013-02-12 | (주)락싸 | Electrical contactless bio-electrical signal measurement apparatus and the method of the same |
| KR101800706B1 (en) * | 2011-03-08 | 2017-11-24 | 삼성전자 주식회사 | Apparatus, unit measurer and method for measuring biological signal without noise |
| KR101832264B1 (en) * | 2011-08-25 | 2018-04-13 | 삼성전자주식회사 | Apparatus and method for measuring bioelectic signals |
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2015
- 2015-05-11 WO PCT/KR2015/004679 patent/WO2016182093A1/en active Application Filing
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1581626A (en) * | 2003-08-05 | 2005-02-16 | 刘金生 | Anti interference method and device |
| KR20080109524A (en) * | 2007-06-13 | 2008-12-17 | 삼성전기주식회사 | Single input differential output type amplifier for multi-band |
| CN102386863A (en) * | 2010-09-02 | 2012-03-21 | 飞兆半导体公司 | Integrated circuit single ended-to-differential amplifier |
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| CN106456037A (en) | 2017-02-22 |
| WO2016182093A1 (en) | 2016-11-17 |
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