CN106456037A - Biosignal measurement device - Google Patents
Biosignal measurement device Download PDFInfo
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- CN106456037A CN106456037A CN201580018958.6A CN201580018958A CN106456037A CN 106456037 A CN106456037 A CN 106456037A CN 201580018958 A CN201580018958 A CN 201580018958A CN 106456037 A CN106456037 A CN 106456037A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/30—Input circuits therefor
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Abstract
The present invention relates to a biosignal measurement device for accurately extracting a biosignal waveform from which common mode noise has been removed through signal correction even when an impedance unbalance between electrodes occurs, comprising: two channels for detecting biopotentials of the human body by means of two electrodes; a biosignal extraction unit, which comprises two sets of detection means for amplifying the biopotentials respectively inputted through the two channels and then performing a differential calculation, and acquires a biosignal by selectively selecting output signals of the two sets of detection means; and an impedance correction means for adjusting an amplification factor of an amplifier such that the power of common mode noise mixed with the biosignal decreases.
Description
Technical field
Even if the present invention relates to impedance unbalance occurring between a kind of electrode, also accurately extracting and being controlled by correction signal
Biological signal measuring device with the bio signal waveform of phase noise.
Background technology
Bio signal is generated from the small electrical signals between human body cell, medical domain be used for confirming patient's states and
Myoelectricity state, mainly has electrocardiogram, electromyogram, E.E.G etc..
As shown in figure 1, including being contacted with the human body that can sense bio signal for measuring the ECG tester of bio signal
Specific part and measure two electrodes 10,20 of biopotential；Received by being connected to the wire 11,21 of electrode 10,20
Biopotential signals simultaneously carry out differential operational to it and obtain the bio signal extraction unit 40 of bio signal；For storing, divide
The signal processing part 50 of the bio signal that analysis, Wireless transceiver or wired transmission are extracted.Described ECG tester also includes the right side
Lower limb drive circuit 60 and for detecting the reference electrode 30 being contacted with human body specific part outside the electrode of biopotential, thus
After bio signal extraction unit 40 is extracted same phase noise and is amplified by inverting amplifier Gr, ginseng is put on by wire 31
Examine electrode 30.
By two electrodes 10,20 with the biopotential signals of two channel measurements for tiny organism signal and relatively large outside
The conjunction of homophase noise signal.External noise signals are in-phase signal, can be detected simultaneously by two electrodes 10,20, therefore, it can
Controlled by the differential operational of bio signal extraction unit 40 and obtain bio signal.
Representative homophase noise signal has the noise signal flowing into by conventional electricity Vs.For example, Korea S commonly uses the frequency of electricity
Rate is 60Hz, and therefore, noise signal is 60Hz, and the frequency of the conventional electricity in Europe is 50Hz, and therefore, noise signal is 50Hz.
Although being only shown with one group of unit measurement apparatus being made up of two electrodes 10,20 in Fig. 1, but it is also possible to by multigroup list
Level measuring arrangement is connected to multiplexer（MUX, multiplexer）, and specific unit measurement apparatus are selectively connectable with
In bio signal extraction unit 40.As Korea S's 10-2012-0102444 publication, it is possible to use multigroup unit measurement apparatus
Extract bio signal.
But, the impedance between electrode and human body changes and when impedance that two electrodes produce changes, much greatly
Same phase noise in bio signal to be measured is possible to be controlled by the differential operational of bio signal extraction unit 40.
That is, between two electrodes occur impedance unbalance when, be far longer than bio signal homophase noise signal can not pass through poor
Dynamic computing is adequately controlled, and with big signal residual, thus the accuracy of biological signal measuring is greatly reduced.
In order to solve the above problems, disclose, in Korean granted patent the 10-0868071st, the electrode that impedance unbalance can be detected
Impedance detection method.
But, due to physical activity, there is imbalance in impedance at any time.And, work as, using electrolyte gel, electrode is attached to people
During body, the hardenability of electrolyte gel also results in the imbalance of impedance.Carry out impedance for each impedance unbalance
Balance, not only loaded down with trivial details, and also inaccurate.
[citation]
[patent documentation]
（Patent documentation 1） KR 10-0868071B1 2008.11.04；
（Patent documentation 2） KR10-2012-0102444A 2012.09.18.
Content of the invention
The purpose of the present invention is to make up the deficiencies in the prior art, even if provide, between one kind electrode, impedance unbalance occurs,
Also the bio signal of electrode detection can be carried out with signal processing, control the same phase noise of remnants that impedance unbalance leads to, thus fast
Speed solves to be produced the biological signal measuring device of problem by impedance unbalance.
In order to achieve the above object, the technical solution used in the present invention is as follows：
Biological signal measuring device of the present invention includes two passages passing through two electrode detection human-body biological potentials；It is provided with two groups
Amplified device amplifies the detector being carried out differential operational after the biopotential of two passage inputs by differential operational device respectively,
And selectively adopt the output signal of two groups of detectors and obtain the bio signal extraction unit of bio signal；Regulation is arranged at two
The amplifier amplification of group detector, is entrained in the same phase noise from the bio signal that bio signal extraction unit obtains to reduce
Power, thus control because of impedance unbalance and the impedance corrector of same phase noise that formed between passage.
Described impedance corrector selects two groups of detectors in turn, and the amplifier amplification adjusting selected detector is up to same phase noise
Less than the same phase noise of unselected detector, when homophase noise power reaches the condition of convergence set in advance, by two groups of detectors
In with the relatively small detector of phase noise output signal as bio signal.
Each passage a detector be connected to be connected to differential operational device "+" amplifier of input, in another detector
It is connected to the amplifier being connected to differential operational device "-" input, described bio signal extraction unit is included to two groups of detectors
Output signal carries out differential operational and obtains the differential operational portion of bio signal, and described impedance corrector adjusts and sets respectively by passage
It is placed in the amplifier amplification of two groups of detectors, so that being doped in same in the bio signal obtaining by described differential operational portion
Phase noise power diminishes.
The beneficial effect of biological signal measuring device of the present invention is：Divide in two passages inputting biopotential by two electrodes
Not She Zhi amplifier, and reduce the power of homophase noise signal by adjusting the amplification of amplifier, thus passing through two electricity
Even if there is impedance unbalance between the two of pole passages, the bio signal controlling with phase noise also can be obtained.
And, when there is impedance unbalance between passage, by being amplified computing using amplifier before differential operational
Signal processing eliminating impedance unbalance, therefore, during measurement bio signal, even if make channel impedance continuous because of physical activity
Change, also can tackle rapidly, thus obtaining accurate waveform bio signal.
In addition, the same phase noise remaining after noise eliminator is eliminated and controlled with phase noise using amplifier of the present invention, thus
More accurate bio signal can be obtained.
Brief description
Fig. 1 is the schematic diagram of existing biological signal measuring device.
Fig. 2 is the first embodiment schematic diagram of biological signal measuring device of the present invention.
Fig. 3 is the partial schematic diagram of Fig. 2.
Fig. 4 is the second embodiment schematic diagram of biological signal measuring device of the present invention.
Fig. 5 is the 3rd embodiment schematic diagram of biological signal measuring device of the present invention.
Fig. 6 is the fourth embodiment schematic diagram of biological signal measuring device of the present invention.
In figure, Z11, Z21：Series impedance；Z12、Z22：Parallel impedance；G1、G2、G3：Differential operational amplifier；G11、G12、
G21、G22、G31、G32：Amplifier；10、20：Electrode；11、21：Wire；30：Reference electrode；40：Bio signal extraction unit（Existing
There is technology）；50th, signal processing part；60：Driven-right-leg circuit；100：Bio signal extraction unit（The present invention）；110、120：Pre- place
Reason portion；130th, differential operational portion；200：Impedance corrector；210th, power draw portion；220：Gain-adjusted portion；300：Residual noise
Canceller；310：With phase noise extraction unit；320：Power ratio extraction unit；330：Homophase noise regulation law portion；340：Subtraction portion.
Specific embodiment
Below in conjunction with the accompanying drawings highly preferred embodiment of the present invention is illustrated, so that those skilled in the art is easy to real
Apply.When the present invention will be described, if the detailed description impact on known function or known features is clear to main points of the present invention
Clear description, then detailed.
Fig. 2 is the first embodiment schematic diagram of biological signal measuring device of the present invention.
As shown in Fig. 2 biological signal measuring device of the present invention includes at least two according to bio signal species to be measured
The mutually different specific part specified detects the electrode 10,20 of human epidermal biopotential；For obtaining to by multiple electricity
The biopotential of two electrode detection of extremely middle selection carries out differential operational and controls the biological letter of the bio signal of same phase noise
Number extraction unit 100；And for storing, analyze, the signal processing part 50 of bio signal that extracted of wired transmission or Wireless transceiver.
Also include two and be arranged at described bio signal extraction unit 100, for amplifying the biology by two electrode inputs respectively
Carry out the amplifier G11 of differential operational, G12 after potential, reduce to be doped in by the regulation of described amplifier amplification and pass through
The impedance corrector 200 of residual homophase noise power in the bio signal that bio signal extraction unit 100 is extracted, further
Control and still residue in the biological letter extracting by bio signal extraction unit 100 after impedance corrector 200 controls same phase noise
Same phase noise in number and be sent to the residual noise canceller 300 of signal processing part 50.
The plurality of electrode 10,20 usually can be attached directly to the contact electrode of human epidermal, by wire 11,21 telecommunications
Number mode is connected to described bio signal extraction unit 100.Although being only shown with two electrodes 10,20 in accompanying drawing, measure myoelectricity
Using at least three electrodes when figure, electrocardiogram or E.E.G.
During using at least two electrodes, it is possible to use multiplexer（MUX,multiplexer）Or any electrode is had by switch
It is selectively docked to bio signal extraction unit 100 it is also possible to configure multiple bio signal extraction units 100 and measure multiple electricity simultaneously
Pole signal.Its connected mode is different according to the difference of biological signal measuring software.
As shown in Fig. 2 when noise signal Vs comes across human body skin with same phase noise, can set up from bio signal extraction unit
100 extract with the driven-right-leg circuit 60 carrying out anti-phase amplification after phase noise, and by being connected to the reference electrode 30 of wire 31
The homophase noise signal of anti-phase amplification is fed back in human body.
Described signal processing part 50 can be according to the mounting means of biological signal measuring device（For example, human body wearing mode）Or use
Purpose deforms setting in different forms.
Described electrode 10,20, reference electrode 30, driven-right-leg circuit 60 and signal processing part 50 are known technology, with regard to noise
Signal Vs, for example, the noise signal that the conventional electricity with certain frequency is produced shows as the analysis of the phenomenon of same phase noise
For known, therefore here simply describes in detail.
The amplifier G11 of 3 couples of present invention, G12, impedance corrector 200 and residual noise canceller 300 are carried out below in conjunction with the accompanying drawings
Describe in detail.
Fig. 3 is the detailed maps of Fig. 2.
As shown in figure 3, not indicating the electrode 10,20 in Fig. 2 and wire 11,21 in Fig. 3, and electrode 10,20 and wire will be comprised
11st, 21 element is denoted as electrical equivalent circuit.
That is, bio signal extraction unit 100 passes through two channel reception biopotentials being made up of electrode 10,20 and wire 11,21
Signal, therefore, is denoted as resulting from the input impedance of two passages.
Contact impedance between electrode 10,20 and human body skin, wire are included by the input impedance that two passages manifest respectively
11st, impedances of 12 generations and before bio signal extraction unit 100, signal processing is carried out to the signal input being received by wire
Filter or amplifier（Not shown）Impedance（Not shown）Deng.As shown in figure 3, series impedance Z11, Z12 can be simplified to
Indicate with parallel impedance Z12, Z22.And, for the wire 31 being connected to driven-right-leg circuit 60 and reference electrode 30,
The outfan of driven-right-leg circuit 60 can also be indicated with series impedance Z31 and parallel impedance Z32.
As described above, being affected by input impedance by the bio signal that electrode senses, being input into bio signal extraction unit 100,
When the input impedance of two passages occurs uneven, the present invention can be by amplifier G11, G12, impedance corrector 200 and residual
Remaining noise eliminator 300 releases the impact of uneven generation.
Described amplifier G11, G12 are by can consist of the amplifier that impedance corrector 200 adjusts amplification, and are connected to
Carry out the differential operational element G1's of differential operational in described bio signal extraction unit 100（+）Input and（-）Input, from
And will be input into differential operational element G's 1 by the biopotential signals of two passage inputs（+）Input and（-）Input
Change amplification respectively before and be amplified.
For example, described amplifier G11, G12 can by amplification change with the unidirectional current size putting on control end controlled
Voltage amplifier（VCA：voltage controlled amplifier）Constitute, described impedance corrector 200 can will be used for
The unidirectional current adjusting described amplifier G11, G12 amplification puts on the control end of described amplifier G11, G12.
Contrast by described amplifier G11, G12 be arranged at bio signal extraction unit 100 before and after be described as follows.
First, illustrate to before arranging described amplifier G11, G12.
Extract bio signal optimum state be, input series impedance Z11, Z12 of bio signal extraction unit 100 identical and
Connection impedance Z 12, Z22 identical impedance balance state.When impedance balance state, it is input into the same of bio signal extraction unit 100
The size of phase noise is identical, thus same phase noise can be eliminated by differential operational.
But, human body has activity somewhat, also can be in series impedance Z11, Z12 according to the contact between electrode and human body skin
The change of resistance etc. and change and there is the impedance unbalance state of different value.Even if it is, the biological letter of initial stage measurement
Number when impedance be in poised state, but, due to human body activity it is impossible to maintain impedance balance state.And, electrode and human body
Contact resistance between skin, characteristic error of key element of each passage of composition etc. also result in the imbalance of impedance.
The homophase effect of noise that impedance unbalance leads to is as follows.
For the ease of calculating, do not do plural number calculating, and assume series impedance Z11, Z21 and parallel impedance Z12, Z22 by resistance
Composition or capacitor composition are constituted, and it is assumed that under impedance balance state, series impedance Z11, Z12 is 100 Ω, parallel impedance
Z11, Z21 are 1000 Ω, the amplification of differential operational amplifier G1 is 1000 times.The bio signal that human body is produced is assumed to be
During 1mV, almost can reach the hundreds times of bio signal to thousands of times with phase noise, will accordingly, as one embodiment of the invention
Human-body biological signal hypothesis is 1000mV.When a certain series impedance Z21 is in the unbalanced state that 100 Ω become 110 Ω, survey
Go out the residue signal with phase noise doped with big value as shown in table 1.
Table 1
As shown in table 1, when a certain series impedance Z21 increases by 10% and is in impedance unbalance state, flow into bio signal extraction unit
The size of 100 same phase noise also changes.If carrying out differential operational with this number, 1V（1000mV）Biological letter
Doped with the same phase noise of 8190mV in number, it is, the homophase noise ratio bio signal producing is much larger.Finally, since it is logical
The difference of small impedance between road and the waveform of bio signal can not be obtained.
In contrast, in embodiments of the invention, it is provided for before amplification carries out differential operational in bio signal extraction unit 100
Described amplifier G11, the G12 of the signal being inputted by each passage, and be amplified by the fine setting of a certain amplifier G12 gain
When, the signal that same phase noise as shown in table 2 obtains controlling can be obtained, i.e. bio signal to be measured shows prominent signal.
Table 2
As shown in table 2, even at channel impedance unbalanced state, it is amplified by the fine setting of a certain amplifier G12 gain,
Also the same phase noise being input into two passages of differential operational amplifier G1 can be made almost identical.Therefore, carry out after amplification differential
Computing and the about 1V that obtains（1000mV）Bio signal in doped with 81.9mV with phase noise waveform.It is, can obtain
The signal waveform of the same phase noise significantly reducing doped with bio signal.
Here, for the ease of contrast table 2 and table 1, the only gain to a certain amplifier G12 is adjusted, but the reality of the present invention
Apply in example, it is possible to increase during the gain of a certain amplifier G12, reduce the gain of another amplifier G11, draw after making differential operational
Bio signal does not almost have changed power, thus controlling same phase noise.
Adjusted by impedance corrector 200 and be arranged at bio signal extraction unit 100 for make up interchannel impedance unbalance
Amplifier G11, G12 amplification.
Described impedance corrector 200 is included from the signal that the differential operational by described bio signal extraction unit 100 obtains
Extract the power draw portion 210 of homophase noise power；And fine setting be arranged at described bio signal extraction unit 100 amplifier G11,
Observe the change of homophase noise power while G12 amplification, and follow the tracks of the amplification making homophase noise power diminish, thus adjusting
The gain-adjusted portion 220 of section amplifier G11, G11 amplification.
Described gain-adjusted portion 220 is to increase the amplification of any one amplifier in two amplifiers G11, G12, and reduces another
The mode of one amplifier amplification changes the amplification of two amplifiers G1, G12.
Adjust the imbalance that described amplifier G11, G12 amplification is to make up interchannel impedance.Specifically, when regulation is put
During big rate, the bio signal power of pre-acquired is preferably maintained in constant.Therefore, shade while micro- increasing a certain amplification another amplification
Rate, finds out the amplification that can reduce homophase noise power.Now, originally increased magnification variable quantity, is then gradually reduced amplification
Rate variable quantity, with this re-adjustments amplification, until same phase noise power convergence be within preset value till.Work as increase
A certain amplification, reduce another amplification in the state of homophase noise power become big when, the direction of inverse change amplification and seek
Look for the amplification that homophase noise power can be made to diminish.
Described power output portion 210 can be by the power of homophase noise signal as conventional electricity frequency content power.For this reason, it is described
Power output portion 210 extracts conventional electricity from the signal being carried out differential operational and being obtained by described bio signal extraction unit 100
Frequency content power, described gain-adjusted portion 220 finely tunes observes conventional electricity frequency content work(while described amplifier G11, G12
Rate, and find out the amplification reducing conventional electricity frequency content power.This is because extract flowing into by conventional conductance during bio signal
The noise signal causing.For example, Korea S using 60Hz composition as same phase noise, Europe is using 50Hz composition as same phase noise.
By for the reference electrode 30 of the driven-right-leg circuit 60 in human body or the 3rd electrode by same phase noise reverse feedback
The homophase noise signal being artificially induced human body is put on after human body, observes corresponding homophase noise signal and adjust described
The amplification of amplifier G11, G12.
The homophase noise signal of described intention can be to be suitable for the signal of the name kind form such as characteristic frequency or AD HOC.When be intended to
When homophase noise signal is characteristic frequency, is extracted by the such as frequency modulation of FFT or extracted using filter；And be intended to
When homophase noise signal is AD HOC, then utilize correlation analysiss（correlation analysis）After method extracts noise size
It is monitored.
For the homophase noise signal using described intention, it is provided for generating the characteristic frequency letter that user presets frequency band
Number or user preset pattern AD HOC signal signal generator（Not shown）With for signal generator
The signal generating puts on the reference electrode 30 of human body or the 3rd electrode.
When set specific frequency signal is put on human body, described power output portion 210 is from by described bio signal extraction unit 100
Carry out in the signal that differential operational draws, extracting described band signal power set in advance, described gain-adjusted portion 220 finely tunes
Check described band signal power set in advance while described amplifier G11, G12 amplification, find out can reduce described pre-
The amplification of the band signal power first setting.
When AD HOC signal is put on human body, AD HOC signal is sensed by electrode and passes through bio signal extraction unit
100 carry out output after signal processing.Therefore, described power draw portion 210 calculating bio signal extraction unit 100 carries out differential operational
Related figure between the signal drawing and the described AD HOC signal putting on human body, described gain-adjusted portion 220 finely tunes institute
State the amplification of amplifier G11, G12, and observe the end value of related figure and find out the amplification that can reduce related figure.Regulation is put
Big rate reduces related figure and has identical meaning with reducing noise power.
Special frequency band signal can not also be set to same phase noise, and adjust for reducing by described bio signal extraction unit
100 amplifications carrying out the signal power that differential operational draws.The method is applicable to that impedance is seriously uneven and described biology
Signal extraction portion 100 carries out differential operational and show that the homophase noise signal in signal is far longer than the state of bio signal.That is, same
It is also possible to not extract characteristic frequency when phase noise signal is very big, and subtract low power method part solution by adjusting amplification
Certainly impedance unbalance.
When described impedance corrector 200, the power ratio extraction unit 320 of residual noise canceller 300 and signal processing part 50 are with micro-
Processor needs to use A/D converter when constituting（analog-to-digital converter）（Do not show in Fig. 3）.In order to logical
Cross the amplification that microprocessor adjusts described amplifier G11, G12, need by D/A converter（dingital-to-analog
converter）It is input into the control end of described amplifier G11, G12 after conversion amplification, Regulate signal.For described biological letter
The element of number extraction unit 100 differential operational can be made up of differential operational amplifier but it is also possible to be obtained by carrying out differential operational
The A/D converter obtaining digital signal is constituted.Described A/D converter or D/A converter are known technology, and here is omitted specifically
Bright.
Even if arranging amplifier G11, G12 in the bio signal extraction unit 100 carry out differential operational, and pass through impedance corrector
The amplification of 200 regulation amplifier G11, G12 carrys out the same phase noise that impedance unbalance between control passage leads to, but, homophase is made an uproar
Sound is also possible to be perfectly controlled and remains.I.e., as shown in table 2, even if the amplification of vernier amplifier G11, G12,
Also can significantly control same phase noise, but be difficult to fine adjustment amplifier.Therefore, by impedance corrector 200 to greatest extent
Control residual to reach after set in advance residual with phase noise with phase noise, controlled using residual noise canceller 300 residual
The same phase noise staying.
Described residual noise canceller 300 extracts homophase noise signal from described bio signal extraction unit 100, and specification chemical conversion is mixed
After miscellaneous homophase noise power in the signal carrying out differential operational and drawing by described bio signal extraction unit 100, from logical
Cross described bio signal extraction unit 100 to carry out deducting in the signal that differential operational draws.With this, eliminated by described residual noise
The same phase noise that device 300 elimination is controlled and remained by two amplifiers G11, G12 and impedance corrector 200, thus
Obtain the bio signal fully controlling with phase noise.
Described residual noise canceller 300 includes being added to be put by be arranged at described bio signal extraction unit 100 two respectively
Signal that big device amplifies and obtain the same phase noise extraction unit 310 of homophase noise signal, draw homophase noise signal for acquisition
The power ratio to the homophase noise power drawing signal by the differential operational of described bio signal extraction unit 100 for the power work(
Rate carries out normalized same phase noise rule than extraction unit 320, the described homophase noise signal obtaining that is multiplied and described power ratio
Generalized portion 330 and deduct from the signal that described bio signal extraction unit 100 differential operational draws standardization homophase noise signal
Subtraction portion 340.
Due to being added respectively by being arranged in the signal that two amplifiers of described bio signal extraction unit 100 are amplified
Doped with the noise signal beyond bio signal or conventional electricity frequency content, therefore, described power ratio extraction unit 320 utilizes described
The processor that power draw portion 210 uses is from the signal being obtained by described same phase noise extraction unit 310 and described bio signal
Described conventional electricity frequency content power is obtained respectively, thus obtaining use in the signal that extraction unit 100 carries out differential operational and obtains
In the homophase noise power obtaining power ratio.
Band signal set in advance can also be applied on abiotic potential measurement electrode, and from by described same phase noise
Homophase noise signal and the letter carrying out differential operational and obtaining by described bio signal extraction unit 100 that extraction unit 310 obtains
Band component power is preset, thus drawing described power ratio described in obtaining respectively in number.
Characteristic frequency（Conventional electricity frequency content or described preset frequency）Content power can pass through fast fourier transform
（FFT：Fast Fourier Transform）Extract and obtain special frequency band power.
When AD HOC signal is put on human body, calculate the AD HOC signal putting on human body and pass through described same phase noise
Correlation between the homophase noise signal that extraction unit 310 obtains is schemed, is put on the AD HOC signal of human body and passes through described biology
After related figure between the signal that signal extraction portion 100 carries out differential operational and obtains, the ratio of the related figure with calculating respectively replaces
Power ratio uses.
Restart described residual noise canceller 300, thus controlling two to greatest extent after first starting described impedance corrector 200
After the same phase noise that individual channel impedance imbalance leads to, residual noise is controlled, and then obtains fully elimination homophase noise flowing
The bio signal waveform entering.
Below the second embodiment of the present invention, 3rd embodiment and fourth embodiment are illustrated.
The present invention second, third, in fourth embodiment, two groups of detectors are parallel to two and lead to by bio signal extraction unit 100
Road, described detector is differential for passing through after being amplified by amplifier respectively by the biopotential of two passages inputs
Arithmetical unit carries out differential operational, is provided only with a bio signal extraction unit 100 in first embodiment, but, second, third enforcement
It is provided with two groups of bio signal extraction units 100 in example：100-1,100-2, be provided with fourth embodiment two groups of pretreatment portions 110,
120.
And, it is additionally provided with described two groups of detectors and the signal exporting respectively selectively can be selected and obtained homophase and make an uproar
Sound obtains the device of the bio signal of control.That is, second embodiment, 3rd embodiment include two groups of detectors are carried out in turn
The selecting device of a certain detector of final choice after selection, fourth embodiment includes selecting two groups of detectors and every to being output in
The signal of individual detector is processed and is obtained the device of bio signal.
Fig. 4 is the second embodiment schematic diagram of biological signal measuring device of the present invention.
As shown in figure 4, biological signal measuring device of the present invention includes two bio signal extraction units 100 being provided with amplifier, institute
State bio signal extraction unit 100 to be made up of the first bio signal extraction unit 100-1 and the second bio signal extraction unit 100-2, institute
State the first bio signal extraction unit 100-1 and the second bio signal extraction unit 100-2 is parallel to two passages.
And, the power draw portion 210 of impedance corrector 200 is from the first bio signal extraction unit 100-1 and the second bio signal
Extraction unit 100-2 obtains respectively and carries out the signal of differential operational and obtain homophase noise power.
Described gain-adjusted portion 220 repeats to adjust as follows process, i.e. adjust two groups of bio signal extraction units 100：100-1、
When the amplification of a certain amplifier in 100-2 makes it be less than another same phase noise with phase noise, put with adjusting a certain amplifier
The process of status adjustment another amplifier amplification of big rate.When homophase noise power reaches the condition of convergence set in advance,
The bio signal obtaining from the little bio signal extraction unit of homophase noise power is selected to be sent to residual noise and disappear with switch 230
Except device 300, described switch 230 can be by multiplexer（MUX,multiplexer）Constitute.
The described condition of convergence set in advance can be the condition or i.e. that homophase noise power is lowered to less than preset value
Make regulation amplification, also because the ratio that diminishes of homophase noise power or the degree that diminishes are slow, and can be less than and preset
Ratio or the ratio of degree or the condition of degree.
Specific embodiment is as follows.
First, in first bio signal extraction unit 100-1 amplifier G11, G12 amplification and the second bio signal extraction unit
The homophase noise power carrying out differential operational and drawing in the state of 100-2 amplifier G21, G22 amplification is identical is compared
Afterwards, select to flow into the bio signal extraction unit of less same phase noise.Such as, if the first bio signal extraction unit 100-1 same
Phase noise is less, then change the amplification of second bio signal extraction unit 100-2 amplifier G21, G22, observes same phase noise
Whether can diminish and the same phase noise less than the first bio signal extraction unit 100-1.The change of described amplification refers to increase
The amplification of a certain amplifier in amplifier G21, G22, and reduce the amplification of another amplifier.
Then, change the amplification of second bio signal extraction unit 100-2 amplifier G21, G22, when same phase noise is less than first
During bio signal extraction unit 100-1, in the state of the amplification changing directly is suitable for, change the first bio signal extraction unit
The amplification of 100-1 amplifier G11, G12, and observe whether same phase noise is less than the second bio signal extraction unit 100-2.First
The amplification of first signal extraction portion 100-1 amplifier G11, G12 is adjusted to the second adjusted bio signal extraction unit 100-2
Change amplification after amplifier G21, G22 amplification.Although this is with respect to another amplifier, its amplification can be reflected
Rate and as change amplification starting point.
As described above, adjusting first bio signal extraction unit 100-1 amplifier G11, G12 and the second bio signal extraction unit in turn
If when reaching the described condition of convergence set in advance during 100-2 amplifier G21, G22, by switch 230 select from
It is doped in and the biology that the relatively small a certain bio signal extraction unit of the homophase noise power of signal obtains is drawn by differential operational
Signal.When impedance contrast changes, repeat said process and again entered in two groups of bio signal extraction units by switching 230
Row selects.
Residual noise canceller 300 includes receiving in two groups of bio signal extraction units 100：100-1,100-2 pass through to amplify respectively
The signal that device amplifies, and select and be adopted as the multiplexing of the signal for obtaining homophase noise signal from the signal receiving
Device（MUX,multiplexer）350.Because described impedance corrector 200 is carried by switching 230 two groups of bio signals of selection
Take portion 100：Some in 100-1,100-2, therefore, described multiplexer（MUX,multiplexer）350 preferably from logical
Cross the bio signal extraction unit receipt signal of switch 230 selection and obtain homophase noise signal.Then, using by multiplexing
Device（MUX,multiplexer）The signal enabling power ratio extraction unit 320 of 350 selections, homophase noise regulation law portion 330 and subtraction
The process in portion 340 is identical with the first embodiment of the present invention, detailed.
Embodiments of the invention include driven-right-leg circuit 60, therefore, it can from described multiplexer（MUX,
multiplexer）The homophase noise signal do not fed back in human body is obtained it is also possible to arrange another multichannel in the signal of 350 selections
Multiplexer（MUX,multiplexer）And from the bio signal extraction unit receipt signals and obtaining of switch 230 selection do not feed back in
The homophase noise signal of human body.
Fig. 5 is the 3rd embodiment schematic diagram of biological signal measuring device of the present invention.
As shown in figure 5, the 3rd embodiment of biological signal measuring device of the present invention is provided with two groups of biological letters such as second embodiment
Number extraction unit 100：100-1,100-2, and by impedance corrector 200 to two groups of bio signal extraction units 100：100-1、100-
2 adjust amplifier amplification in turn, and select with the relatively small bio signal extraction unit of phase noise.Except for the difference that, multiple with multichannel
Replace the switch 230 in second embodiment to select bio signal extraction unit with device 230 '.
Residual noise canceller 300 does not include such as the same phase noise extraction unit 310 in first embodiment and second embodiment, and sharp
Used in two groups of bio signal extraction units 100：The bio signal not selected by described multiplexer 230 ' in 100-1,100-2 carries
Portion is taken to obtain homophase noise signal.
Specifically, the gain-adjusted portion 220 of impedance corrector 200 is such as second embodiment, to two groups of bio signal extraction units
100：100-1,100-2 are amplified the regulation of device amplification in turn, and select homophase under the condition of convergence set in advance to make an uproar
After the relatively small bio signal extraction unit of sound, control and do not have one of selected two amplifiers of bio signal extraction unit to enter
Row is anti-phase to be amplified or blocks the output amplifying signal（It is identical when 0 with amplification）.Now, in non-selected bio signal
The signal that extraction unit carries out differential operational and draws is the dominant signal of same phase noise, i.e. although doped with life to be measured
Thing signal, but it is far longer than bio signal with phase noise.
While described multiplexer 230 ' selects with phase noise little bio signal extraction unit, swap and make not selected
The output of another bio signal extraction unit selected is sent to the homophase noise regulation law portion 330 of residual noise canceller 300.
Power ratio extraction unit 320 calculates and is output in two bio signal extraction units 100 respectively：Same in the signal of 100-1,100-2
The power of phase noise frequency band, and calculate to the output letter being doped in the bio signal extraction unit that described multiplexer 230 ' selects
Number（Impedance unbalance between correction channel and control the signal of same phase noise）Homophase noise band power be doped in not many
The bio signal extraction unit signal that path multiplexer 230 ' selects（It is far longer than the signal of bio signal with phase noise）Homophase make an uproar
Sonic-frequency band power ratio, the power ratio of calculating is reflected in homophase noise regulation law portion 330.
Normalized same phase noise is obtained by homophase noise regulation law portion 330, and is controlled by subtraction portion 340 and residue in and pass through
The same phase noise of the bio signal extraction unit output signal that multiplexer 230 ' selects.In 3rd embodiment shown in Fig. 5, work(
Rate is more identical with first, second embodiment than extraction unit 320, homophase noise regulation law portion 330 and subtraction portion 340, omits specifically
Bright.
As shown in figure 5,3rd embodiment also includes driven-right-leg circuit 60, therefore, it is additionally provided with two groups of bio signals of selection to extract
Portion 100：In 100-1,100-2 any one and obtain the multiplexer 61 of same phase noise.
Described 3rd embodiment is not provided with residual noise canceller 300 compared with second embodiment.Can certainly be by impedance
Corrector 200 and residual noise canceller 300 as a microprocessor, be used in power draw portion 210 for obtaining
The processor of homophase noise power is used in power ratio extraction unit 320.
Fig. 6 is the fourth embodiment schematic diagram of biological signal measuring device of the present invention.
As shown in fig. 6, bio signal extraction unit 100 include respectively by amplifier amplify by be made up of electrode and wire two
Carry out differential operational after the biopotential signals of each passage of individual passage ch1, ch2 input and obtain respectively and carry out pretreatment
The first pretreatment portion 110 of signal and the second pretreatment portion 120, standardization power make in the first pretreatment portion 110 and second
After the homophase noise power of the signal carrying out pretreatment that pretreatment portion 120 obtains respectively is identical, carries out differential operational and obtain
The differential operational portion 130 of the bio signal of same phase noise must be controlled.
Described impedance corrector 200 corrects to be respectively arranged at simultaneously and is made up of the first pretreatment portion 110 and the second pretreatment portion 120
The each passage of two groups of pretreatment portions amplifier amplification, and follow the tracks of regulation amplification, make to be doped in by described differential operational
Homophase noise power in the bio signal that portion 130 obtains diminishes.
Described first pretreatment portion 110 and the second pretreatment portion 120 are parallel to passage ch1, ch2, and passage is connected to arbitrarily
One pretreatment portion differential operational device "+" input, the differential operational device "-" input of another pretreatment portion.
Specifically, differential operational device G1, G2 of being respectively arranged at the first pretreatment portion 110 and the second pretreatment portion 120 are to defeated
Enter "+" signal of input and "-" input carries out differential operational, a passage ch1 is connected to first and locates in advance
Reason portion 110 and the second pretreatment portion 120, are connected to differential operational device G1's in the first pretreatment portion 110 by amplifier G11
"+" input, is connected to the "-" input of differential operational device G2 in the second pretreatment portion 120 by amplifier G22.
Another passage ch2 is diverged and is connected to by amplifier respectively in the first pretreatment portion 110 and the second pretreatment portion 120
Another input of differential operational device.That is, another passage ch2 be connected to by amplifier G12 in the first pretreatment portion 110 differential
Arithmetical unit G1 "-" input, the second pretreatment portion 120 by amplifier G21 be connected to differential operational device G2 "+" input
End.
It is, being exchanged with each other the differential operational device G1 input polarity and of the first pretreatment portion 110 of input channel signal
Two pretreatment portion 120 differential operational device G2 input polarity.
As described above, the first pretreatment portion 110 and the second pretreatment portion 120 are connected to passage ch1, ch2, and pass through two and lead to
Homophase noise contribution in the biopotential signals that road ch1, ch2 flow into is through the first pretreatment portion 110 and the second pretreatment portion
When 120, the noise contribution of pretreatment is carried out by the first pretreatment portion 110 and pretreatment carried out by the second pretreatment portion 120
Noise contribution anti-phase or homophase can be become according to the amplification of amplifier G11, G12, G21, G22.
But, any one polarity in predesignated differential operational device G1, G2 input polarity, it is connected to specify polarity defeated
The ratio of the amplifier amplification entering end and the amplifier amplification being connected to another polarity is more than interchannel homophase noise power
Than when, be doped in and carry out the noise contribution signal in the signal of pretreatment in the first pretreatment portion 110 and the second pretreatment portion 120
It is changed into homophase.
As shown in fig. 6, amplifier G11 locates in advance to the amplification ratio of amplifier G12 with second in the first pretreatment portion 110
In reason portion 120, amplifier G21 is more than the same phase noise letter flowing into by passage ch1, ch2 to the amplification ratio of amplifier G22
During number power ratio, it is doped in the noise carrying out in the signal of pretreatment in the first pretreatment portion 110 and the second pretreatment portion 120 and becomes
Sub-signal is changed into homophase.
Now, pretreatment is carried out to by the first pretreatment portion 110 and the second pretreatment portion 120 by differential operational portion 130
Signal carries out differential operational to control homophase noise signal.
Described impedance corrector 200 makes to lead to when the amplifier amplification adjusting the first pretreatment portion 110 and the second pretreatment portion 120
When diminishing with phase noise in the signal crossing the acquisition of described differential operational portion 130, it is same that the convergence of amplifier amplification makes it have control
Ratio between the amplification of phase noise signal conditioning.
In embodiments of the invention, in order to follow the tracks of rapidly the amplification being arranged at the first pretreatment portion 110 and the second pretreatment portion 120
Device amplification, a certain polarity in predesignated pretreatment portion 110,120 differential operational device input polarity, and be connected to refer to
The amplifier amplification determining polarity input is more than the amplifier amplification being connected to another polarity, adjusts amplification with this.Tool
For body, be arranged at differential operational device G1, G2 "+" amplifier G11, G12 amplification of input is more than and is arranged at differential fortune
Calculate device G1, G2 "-" input amplifier G12, G22 amplification under conditions of finely tune amplification while be amplified rate with
Track.
In contrast, during following the tracks of amplification, according to the position of the electrode 10,20 for obtaining bio signal（It is attached to
The position of human body）, in the biopotential signals being flowed into by two passages ch1, ch2 anti-phase bio signal composition even across
First pretreatment portion 110 and the second pretreatment portion 120, that is, carry out the biological letter of pretreatment by the first pretreatment portion 110
Number composition and be anti-phase by the bio signal composition that the second pretreatment portion carries out pretreatment.
Even if by the differential operational in differential operational portion 130 nor anti-phase in the signal being obtained by pretreatment to being doped in
Bio signal is controlled, and obtains on the contrary and has fully powerful bio signal.
As shown in fig. 6, described differential operational portion 130 passes through amplifier G31, G32 respectively to by the first pretreatment portion 110 and the
The signal that two pretreatment portions 120 carry out pretreatment and obtain carries out differential operational by differential operational device G3 after being amplified, and
Adjust the amplification of each amplifier G31, G32 by power normalization portion 131.
That is, described power normalization portion 131 from carried out by described first pretreatment portion 110 and the second pretreatment portion 120 pre- from
Extraction homophase noise contribution signal power in the signal of reason, and adjust the amplification of described amplifier G31, G32, so that being doped in
Homophase noise contribution signal in the signal of pretreatment is carried out by described first pretreatment portion 110 and the second pretreatment portion 120
Power identical.Can also the amplification of any one amplifier in two amplifiers G31, G32 be adjusted making homophase
The power of noise contribution signal is identical.
Be input into respectively described differential operational device G3 "+" the homophase noise power of the signal of input and "-" input
Identical, therefore, the signal of same phase noise is controlled by the differential operational of described differential operational device G3, i.e. control can be obtained same
The fully big signal of phase noise, bio signal.During extracting homophase noise power, error etc. can occur, therefore, homophase is made an uproar
Same phase noise can fully be controlled into desired level by the differential operational of described differential operational device G3 by the identical meaning of acoustical power.
Adjust the amplification of the first pretreatment portion 110 amplifier G11, G12 and the second pretreatment portion 120 amplifier G21, G22
Amplification, makes by being provided with the signal that the differential operational portion 130 in described power normalization portion 131 carries out differential operational and obtains
Same phase noise minimum, thus, even if occurring impedance unbalance also can obtain the bio signal controlling with phase noise, and using can
Poor after making the change of homophase noise power identical by amplifier G31, G32 that described power normalization portion 131 adjusts amplification
Dynamic computing, actually acquisition are the bio signals eliminating with phase noise.Therefore, can not wrap in the fourth embodiment of the present invention
Include the residual noise canceller 300 being provided with the present invention first, second, third embodiment.
The extraction for normalized homophase noise power in described power normalization portion 131 and described impedance corrector 200
The extraction of the homophase noise power followed the tracks of for amplification can be normal by illustrate in the present invention first, second, third embodiment
The extraction of electricity consumption frequency content power, apply to preset the signal of frequency band after preset band signal power extraction and
AD HOC signal set in advance is put on any in the extraction presetting AD HOC signal power after human body
One composition.
When extracting AD HOC signal power set in advance, it is little that described impedance corrector 200 regulation amplification makes correlation attempt to change,
As the first embodiment of the present invention, second embodiment, 3rd embodiment, described differential operational portion 130 calculates in two groups of pretreatment
The signal that portion 110,120 carries out differential operational respectively and obtains is schemed to presetting the related of AD HOC signal, thus adjusting
The amplification of amplifier G31, G32, so that related figure is identical.
Above-mentioned explanation is only the detailed description to the embodiment of the present invention, but the scope of the present invention is not limited to above-mentioned enforcement
Mode.Claims and description and its shown in the drawings within the scope of by some modifications, can achieve different enforcements
Mode, and this modification should belong to the scope of the present invention.
Claims (9)
1. a kind of biological signal measuring device it is characterised in that：Pass through two electrode detection human-body biological potentials including two
Passage；Be provided with two groups of amplified devices amplify respectively carried out by differential operational device after the biopotential of two passages input differential
The detector of computing, and selectively adopt the output signal of two groups of detectors and obtain the bio signal extraction of bio signal
Portion；Adjust the amplifier amplification being arranged at two groups of detectors, be entrained in, to reduce, the biology obtaining from bio signal extraction unit
Homophase noise power in signal, thus control because of impedance unbalance and the impedance correction of same phase noise that formed between passage
Device.
2. biological signal measuring device according to claim 1 it is characterised in that：Described impedance corrector selects two in turn
Group detector, adjusts the amplifier amplification of selected detector until be less than the same phase noise of unselected detector with phase noise, when
When homophase noise power reaches the condition of convergence set in advance, will be defeated with the relatively small detector of phase noise in two groups of detectors
Go out signal as bio signal.
3. biological signal measuring device according to claim 2 it is characterised in that：Described impedance corrector is adjusted by Selected Inspection
During the amplifier amplification of survey device, first adjust to the amplifier amplification of unselected detector, then proceed by regulation.
4. biological signal measuring device according to claim 2 it is characterised in that：Also include residual noise canceller, institute
State that residual noise canceller will be arranged on any one detector in two groups of detectors of described bio signal extraction unit two
The input signal of individual amplifier obtains homophase noise signal after being added, and the homophase noise signal specification chemical conversion of acquisition is doped in
After the homophase noise power of the bio signal being obtained by described bio signal extraction unit, from by described bio signal extraction unit
Deduct in the bio signal obtaining and obtain and control the remaining bio signal with phase noise.
5. biological signal measuring device according to claim 4 it is characterised in that：After first starting described impedance corrector
Restart described residual noise canceller, thus first controlling the same phase noise being formed because of interchannel impedance unbalance, Ran Houzai
Control remaining same phase noise.
6. biological signal measuring device according to claim 1 it is characterised in that：Each passage is connected in a detector
Be connected to differential operational device "+" amplifier of input, be connected in another detector that to be connected to differential operational device "-" defeated
Enter the amplifier at end, described bio signal extraction unit includes carrying out differential operational to the output signal of two groups of detectors and obtains life
The differential operational portion of thing signal, the amplifier that described impedance corrector is adjusted by passage is respectively arranged at two groups of detectors amplifies
Rate, so that the homophase noise power being doped in the bio signal being obtained by described differential operational portion is diminished.
7. biological signal measuring device according to claim 6 it is characterised in that：Described bio signal extraction unit differential
Operational part carries out differential operational after the output signal of two groups of detectors is standardized, obtain bio signal, make to be doped in two
Homophase noise power in the output signal of group detector is identical.
8. biological signal measuring device according to claim 7 it is characterised in that：Described impedance corrector presets and sets
It is placed in one of the differential operational device input polarity of detector polarity, adjust the amplifier being connected to specified polarity input
Amplification is so as to be more than the amplifier amplification being connected to another polarity input.
9. the biological signal measuring device according to claim 5 or 8 it is characterised in that：Homophase noise power is by conventional electricity
Frequency content power, put on human body preset band signal power and the specific mould being pre-adjusted putting on human body
One of formula signal power is constituted.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2015/004679 WO2016182093A1 (en) | 2015-05-11 | 2015-05-11 | Biosignal measurement device |
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| CN106456037A true CN106456037A (en) | 2017-02-22 |
| CN106456037B CN106456037B (en) | 2019-07-12 |
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| WO (1) | WO2016182093A1 (en) |
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|---|---|---|---|---|
| JPH04160914A (en) * | 1990-10-25 | 1992-06-04 | Pioneer Electron Corp | Isolator circuit |
| JP2003235823A (en) * | 2002-02-15 | 2003-08-26 | Naohiro Toda | External ac noise eliminating system for biological electric signal |
| CN1581626A (en) * | 2003-08-05 | 2005-02-16 | 刘金生 | Anti interference method and device |
| KR20080109524A (en) * | 2007-06-13 | 2008-12-17 | 삼성전기주식회사 | Single input differential output type amplifier for multi-band |
| US20110237904A1 (en) * | 2010-03-26 | 2011-09-29 | Samsung Electronics Co., Ltd. | Method and apparatus for measuring biological signal |
| CN102386863A (en) * | 2010-09-02 | 2012-03-21 | 飞兆半导体公司 | Integrated circuit single ended-to-differential amplifier |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101800706B1 (en) * | 2011-03-08 | 2017-11-24 | 삼성전자 주식회사 | Apparatus, unit measurer and method for measuring biological signal without noise |
| KR101227413B1 (en) * | 2011-03-08 | 2013-02-12 | (주)락싸 | Electrical contactless bio-electrical signal measurement apparatus and the method of the same |
| KR101832264B1 (en) * | 2011-08-25 | 2018-04-13 | 삼성전자주식회사 | Apparatus and method for measuring bioelectic signals |
-
2015
- 2015-05-11 CN CN201580018958.6A patent/CN106456037B/en not_active Expired - Fee Related
- 2015-05-11 WO PCT/KR2015/004679 patent/WO2016182093A1/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04160914A (en) * | 1990-10-25 | 1992-06-04 | Pioneer Electron Corp | Isolator circuit |
| JP2003235823A (en) * | 2002-02-15 | 2003-08-26 | Naohiro Toda | External ac noise eliminating system for biological electric signal |
| CN1581626A (en) * | 2003-08-05 | 2005-02-16 | 刘金生 | Anti interference method and device |
| KR20080109524A (en) * | 2007-06-13 | 2008-12-17 | 삼성전기주식회사 | Single input differential output type amplifier for multi-band |
| US20110237904A1 (en) * | 2010-03-26 | 2011-09-29 | Samsung Electronics Co., Ltd. | Method and apparatus for measuring biological signal |
| CN102386863A (en) * | 2010-09-02 | 2012-03-21 | 飞兆半导体公司 | Integrated circuit single ended-to-differential amplifier |
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|---|---|
| CN106456037B (en) | 2019-07-12 |
| WO2016182093A1 (en) | 2016-11-17 |
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