CN106426687A - Equipment for manufacturing polymer microneedles - Google Patents
Equipment for manufacturing polymer microneedles Download PDFInfo
- Publication number
- CN106426687A CN106426687A CN201610903555.6A CN201610903555A CN106426687A CN 106426687 A CN106426687 A CN 106426687A CN 201610903555 A CN201610903555 A CN 201610903555A CN 106426687 A CN106426687 A CN 106426687A
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- CN
- China
- Prior art keywords
- equipment
- pumping board
- coated substrate
- vacuum pumping
- vacuum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
- B29C39/02—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
- B29C39/22—Component parts, details or accessories; Auxiliary operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
- B29C39/22—Component parts, details or accessories; Auxiliary operations
- B29C39/42—Casting under special conditions, e.g. vacuum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/759—Needles
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Coating Apparatus (AREA)
Abstract
The invention discloses equipment for manufacturing polymer microneedles. A conveying mechanism includes a conveying belt and a conveying motor for driving the conveying belt; the conveying belt is fixed with a vacuum sucking plate fixed frame; the vacuum sucking plate fixed frame is fixed with a vacuum sucking plate; the vacuum sucking plate is communicated with a vacuum pump through a pipeline; a coating unit is arranged above the vacuum sucking plate, and includes a coating substrate, a liquid injecting device for injecting liquid to the surface of the coating substrate and a scraper for scraping the liquid coated on the coating substrate; a drying unit for drying the coating substrate is arranged above the vacuum sucking plate, and includes a drying box and a flow equalizing cover; the flow equalizing cover is arranged in the drying box; and an intake port is fixed in the top of the drying box, and is connected with a fan. As the vacuum sucking plate is connected with the vacuum pump, the equipment is always kept in a negative pressure state, high-viscosity liquid flows into an inverted conical pattern of the coating substrate to achieve the purpose of liquid degassing, and the quality of mold-manufactured products is improved.
Description
Technical field
The present invention relates to polymer micro needle technical field is and in particular to a kind of equipment for making polymer micro needle.
Background technology
At present, the preparation method of micropin is probably divided into casting method, pulling method, microcomputer bed processing method, photoetch method, centrifugation to prolong
Stretch the skill of handling needles processed, coating carries medicine, extrusion stamped method, electric field method, 3D printing method.
Casting method makes in polymer micro needle technique, needs substrate melt/fluid injection mould.Mould silica gel, resin
The mould making Deng material is applied to many industries, the overmolded of such as precision instruments, automobile tire mould, PU resin, insatiable hunger
With the mould of the artwares such as resin, glass, crystal, wax candle, the Making mold of a lot of industry such as plastic toy gift stationery.Micropin
Mould generally has small recess and high aspect ratio, such as because air, surface tension and air cannot be driven away, can produce no
Method forms the technical problem of the part of micropin.During especially making, using casting, the accurate device that surface carries projection,
The solution using more sticky it is not easy to enter into the micropore of mould in, and unavoidable in casting process produce bubble and solid
During change, bubble is not easy to exclude, and the presence of bubble can affect the quality of device to a certain extent.
Accordingly, it is desirable to provide a kind of equipment for making polymer micro needle, it is provided with coater unit and drying unit, coating
Pass through setting vacuum pumping board below mould in unit to be connected with vacuum pump, and make mould inside remain negative pressure state, from
And reach and make high viscosity liquid flow into mould micropore, the purpose of liquid degassing, thus improve the product quality of Mold Making.
Content of the invention
The technical problem to be solved in the present invention is to provide a kind of equipment for making polymer micro needle, logical in coater unit
Cross setting vacuum pumping board below mould to be connected with vacuum pump, and make mould inside remain negative pressure state, thus reach making
High viscosity liquid flows into mould micropore, the purpose of liquid degassing, thus improving the product quality of Mold Making, drying unit is arranged
Drying baker, is quickly and evenly dried the polymer micro needle of coated unit formation.
For solving above-mentioned technical problem, the present invention adopts following technical proposals：
A kind of equipment for making polymer micro needle, including coater unit, drying unit, vacuum pump and transmission mechanism；
Described transmission mechanism includes conveyer belt and the transmission motor for driving transmission belt, and described conveyer belt is fixed with vacuum pumping board
Fixed mount, described vacuum pumping board is fixedly arranged on the fixing bracket with vacuum pumping board, and described vacuum pumping board passes through pipeline connection with vacuum pump
Connect；Coater unit is set above described vacuum pumping board, and described coater unit includes coated substrate and for fluid injection to coating base
The priming device on piece surface；It is provided for the drying unit of drying coated substrate, described drying unit above described vacuum pumping board
Cover including drying baker and all stream, described all stream cover is arranged in drying baker, and the top of described drying baker is fixed with air inlet, institute
State air inlet to be connected with blower fan.
Preferably, described coater unit also include for the solution on coated substrate is struck off scraper plate, slide rail, extraction raffinate receive
Collector, cleaning hydraulic giant and rhone, described coated substrate is laid on vacuum pumping board, and described priming device and scraper plate can be in slide rails
Upper slip, one end of described vacuum pumping board is fixedly installed extraction raffinate collecting pipe and cleaning hydraulic giant, and the lower section of described cleaning hydraulic giant is fixed
Setting rhone.The solution that described extraction raffinate collecting pipe remains after being used for reclaiming blade coating；Described cleaning water tank is used for rinsing scraper plate table
The solution that face is sticked.Described priming device is connected with fluid reservoir.
Preferably, described vacuum pumping board includes panel and disk body, and the edge of described panel seals affixed, described face with disk body
Plate is provided with the evacuation micropore of array arrangement, a diameter of 0.3mm-2mm of described evacuation micropore, adjacent evacuation micropore
Distance is 0.5mm-5mm；Described disk body is provided with the airway being interconnected and is connected with evacuation micropore, described airway with
Vacuum pump is connected, and the panel of described vacuum pumping board 3 is placed coated substrate, described coated substrate, vacuum pumping board and vacuum pump
Between to form the Absolute truth reciprocal of duty cycle of vacuum area be 70kpa to 101kpa (relative degree of vacuum be -70kpa to -101kpa).Described
Vacuum pump continues evacuation it is ensured that in coating process, making to remain negative pressure state inside vacuum pumping board, thus reach making height
Viscous liquid flows in the female pattern hole applying cloth layer, removes the gas in high viscosity liquid, thus improving production effect
Rate and make the product material made full.
Preferably, the surface of described coated substrate is provided with female pattern, and described female pattern is basal diameter or the length of side is little
Inverted cone pattern in 1mm and more than 0.01mm, the thickness of described coated substrate is 0.3mm-3mm；Described coated substrate has
Flexibility, breathability and impermeability, material is silicone rubber or polyurethane material.
Preferably, the bottom of described drying unit is provided with vent, and the wind pushing temperature of described drying unit is degree -60 degree,
The wind speed that described drying unit air inlet reaches coated substrate surface is 0.2m/s-2m/s.
Preferably, at least two vacuum pumping board fixed mounts on described conveyer belt.Vacuum is arranged on vacuum pumping board fixed mount
Pumping board, setting on vacuum pumping board applies cloth layer, completes the process being coated with and being dried.
Preferably, the liquid injecting mouth of described priming device is no less than one, and is arranged side by side.Multiple liquid injecting mouths can guarantee that fluid injection
Speed.Connected by pipeline between fluid reservoir, liquid injecting mouth and liquid driving device, liquid injecting mouth is fixed on three by holder
In dimension travel mechanism, liquid injecting mouth can move in tri- directions of X, Y, Z.
Preferably, the height adjustable of described priming device and scraper plate.Scraper plate is fixed on slide rail, can X-direction move.Note
The height adjustable of liquid device and scraper plate is it is ensured that the liquid injecting mouth of priming device and the lower limb of scraper plate touch the upper of coated substrate
Surface.
Preferably, this equipment also includes control system, and described control system is filled with vacuum pump, driving motor, blower fan, fluid injection
Put, scraper plate, flushing hydraulic giant and extraction raffinate collecting pipe electrically connect.Control system controls coordinates vacuum pump, driving motor, blower fan, fluid injection
Device, the manipulation of scraper plate, flushing hydraulic giant and extraction raffinate collecting pipe and operating.
Preferably, this equipment also includes display system, and described display system is connected with control system, for receiving and showing
The data of control system and information；Control vacuum pump, driving motor, blower fan, priming device, scrape by the setting of display system
The motion of plate, flushing hydraulic giant and extraction raffinate collecting pipe.
Beneficial effects of the present invention are as follows：
A kind of equipment for making polymer micro needle of the present invention, due to employing above technical scheme, is provided with coating single
Unit and drying unit, are passed through setting vacuum pumping board and are connected with vacuum pump, and make equipment remain negative pressure state in coater unit,
Thus reach making high viscosity liquid flow in the inverted cone pattern applying cloth layer, the purpose of liquid degassing, thus improve polymer
The product quality of micropin, drying unit arranges drying baker, is quickly and evenly dried on the coated painting cloth layer of coated unit
Polymer micro needle.
Brief description
Below in conjunction with the accompanying drawings the specific embodiment of the present invention is described in further detail.
Fig. 1 illustrates a kind of overall structure diagram of equipment for making polymer micro needle of the present invention.
Fig. 2 illustrates a kind of coater unit structural representation of equipment for making polymer micro needle of the present invention.
Fig. 3 illustrates a kind of drying unit structural representation of equipment for making polymer micro needle of the present invention.
Fig. 4 illustrates a kind of wind direction schematic diagram of the drying unit of equipment for making polymer micro needle of the present invention.
The each labelling of in figure is as follows：1 coater unit, 101 slide rails, 102 priming devices, 103 scraper plates, 104 extraction raffinate collecting pipes,
105 cleaning hydraulic giants, 106 rhones, 107 coated substrates, 2 drying units, 201 air inlets, 202 drying baker, 203 all streams cover, and 204
Vent, 3 vacuum pumping boards, 4 vacuum pumping board fixed mounts, 5 conveyer belts, 6 transmission motors, 7 vacuum pumps, 8 control systems, 9 display systems
System
Specific embodiment
In order to be illustrated more clearly that the present invention, with reference to preferred embodiments and drawings, the present invention is done further
Bright.In accompanying drawing, similar part is indicated with identical reference.It will be appreciated by those skilled in the art that institute is concrete below
The content of description is illustrative and be not restrictive, and should not be limited the scope of the invention with this.
As Figure 1-Figure 4, a kind of equipment for making polymer micro needle, including coater unit 1, drying unit 2, true
Empty pump 7 and transmission mechanism；Described transmission mechanism includes conveyer belt 5 and the transmission motor 6 for driving transmission belt 5, described transmission
It is fixed with vacuum pumping board fixed mount 4, at least two vacuum pumping board fixed mounts 4 on described conveyer belt 5 on band 5.Described vacuum
Vacuum pumping board 3 is fixed with pumping board fixed mount 4, described vacuum pumping board 3 is connected by pipeline connection with vacuum pump 7.
Described vacuum pumping board 3 top setting coater unit 1, described coater unit 1 includes coated substrate 107, is used for fluid injection
Priming device 102 and the scraper plate 103 for striking off the solution on coated substrate 107 to coated substrate 107 surface；Described note
The liquid injecting mouth of liquid device 102 is no less than one, and is arranged side by side.Described coater unit 1 also includes slide rail 101, extraction raffinate collecting pipe
104th, cleaning hydraulic giant 105 and rhone 106, described coated substrate 107 is laid on vacuum pumping board 3, described priming device 102 He
Scraper plate 103 can slide on slide rail 101, and one end of described vacuum pumping board 3 is fixedly installed extraction raffinate collecting pipe 104 and cleaning hydraulic giant
105, the lower section of described cleaning hydraulic giant 105 is fixedly installed rhone 106.The height of described priming device 102 and scraper plate 103 can
Adjust.
Described priming device 102, scraper plate 103, extraction raffinate collecting pipe 104, cleaning hydraulic giant 105 and rhone 106 control all
It is can be with independent control.That is, after priming device fluid injection, blade coating, extraction raffinate collection, cleaning and drain function can not be carried out,
It is directly entered drying process.
It is provided for the drying unit 2 of drying coated substrate 107, described drying unit 2 includes above described vacuum pumping board 3
Drying baker 202 and all stream cover 203, described all stream cover 203 is arranged in drying baker 202, and the top fixation of described drying baker 202 sets
There is air inlet 201, described air inlet 201 is connected with blower fan.The bottom of described drying unit 2 is provided with vent 204, described drying
The wind pushing temperature of unit 2 is 4 degree of -60 degree, and the wind speed that described drying unit 2 air inlet 201 reaches coated substrate 107 surface is
0.2m/s-2m/s.
Described vacuum pumping board 3 includes panel and disk body, and the edge of described panel and disk body sealing are affixed, and described panel sets
There are the evacuation micropore of array arrangement, a diameter of 0.3mm-2mm of described evacuation micropore, the distance of adjacent evacuation micropore is
0.5mm-5mm；Described disk body is provided with the airway being interconnected and is connected with evacuation micropore, described airway and vacuum pump
7 are connected, and the panel of described vacuum pumping board 3 is placed coated substrate 107, described coated substrate 107, vacuum pumping board 3 and vacuum
The Absolute truth reciprocal of duty cycle forming vacuum area between pump 7 is 70kpa to 101kpa (relative degree of vacuum is that -70kpa arrives -101kpa).
The surface of described coated substrate 107 is provided with female pattern, and described female pattern is basal diameter or the length of side is less than 1mm
And the inverted cone pattern more than 0.01mm, the thickness of described coated substrate 107 is 0.3mm-3mm；Described coated substrate 107 has
Flexibility, breathability and impermeability, material is silicone rubber or polyurethane material.
This equipment also includes control system 8 and display system 9, described control system 8 and vacuum pump 7, driving motor 6, wind
Machine, priming device 102, scraper plate 103, flushing hydraulic giant 105 and extraction raffinate collecting pipe 104 electrically connect.Described display system 9 and control system
System 8 connection, controls vacuum pump 7, driving motor 6, blower fan, priming device 102, scraper plate 103, punching by the setting of display system 9
Wash water rifle 105 and the motion of extraction raffinate collecting pipe 104.
The micropin fabrication processing of present device：
First by the infusion preparing in fluid reservoir, in the UI Preferences technological parameter of display system 9.Will
Coated substrate 107 is placed on vacuum pumping board 3, and opening vacuum pump 7 makes coated substrate 107 adsorb on vacuum pumping board 3.Open fluid injection
Device 102, the liquid injecting mouth of priming device 102 starts fluid injection on coated substrate 107；Open scraper plate 103, start blade coating coating base
The solution of piece 107 upper surface；Open the residual solution after extraction raffinate recovery tube 104 reclaims blade coating；Open and rinse hydraulic giant 105, rinse
Residual solution on scraper plate 103, the residual solution after flushing enters rhone 106 and discharges.
Coated substrate 107 after coating, under the drive of vacuum pumping board 3, is sent to the drying of drying unit 2 by conveyer belt 5
In case 202, open blower fan, the wind of blower fan is blown to coated substrate 107 through all flowing cover 203 by air inlet 201, by drying unit
The vent 204 of 2 bottoms is discharged, and wind pushing temperature is 4 degree of -60 degree, and the wind speed reaching coated substrate 107 surface is 0.2m/s-2m/
s.
Dried coated substrate 107 is removed from vacuum pumping board 3, and vacuum plate sucking 3 returns to initial position, repeats above-mentioned mistake
Journey.
Obviously, the above embodiment of the present invention is only intended to clearly illustrate example of the present invention, and is not right
The restriction of embodiments of the present invention, for those of ordinary skill in the field, also may be used on the basis of the above description
To make other changes in different forms, all of embodiment cannot be exhaustive here, every belong to this
Obvious change that bright technical scheme is extended out or change the row still in protection scope of the present invention.
Claims (10)
1. a kind of equipment for making polymer micro needle it is characterised in that：Including coater unit (1), drying unit (2), true
Empty pump (7) and transmission mechanism；
The transmission motor (6) that described transmission mechanism includes conveyer belt (5) and is used for driving transmission belt (5), on described conveyer belt (5)
It is fixed with vacuum pumping board fixed mount (4), described vacuum pumping board fixed mount (4) is fixed with vacuum pumping board (3), described vacuum
Pumping board (3) is connected by pipeline connection with vacuum pump (7)；
Setting coater unit (1) above described vacuum pumping board (3), described coater unit (1) includes coated substrate (107) and is used for
Fluid injection is to the priming device (102) on coated substrate (107) surface；
It is provided for the drying unit (2) of drying coated substrate (107), described drying unit (2) above described vacuum pumping board (3)
Cover (203) including drying baker (202) and all stream, described all stream cover (203) is arranged in drying baker (202), described drying baker
(202) top is fixed with air inlet (201), and described air inlet (201) is connected with blower fan.
2. a kind of equipment for making polymer micro needle according to claim 1 it is characterised in that：Described coater unit
(1) also include for the solution on coated substrate (107) is struck off scraper plate (103), slide rail (101), extraction raffinate collecting pipe
(104), cleaning hydraulic giant (105) and rhone (106), described coated substrate (107) is laid on vacuum pumping board (3), described note
Liquid device (102) and scraper plate (103) can be in the upper slips of slide rail (101), and one end of described vacuum pumping board (3) is fixedly installed extraction raffinate and receives
Collector (104) and cleaning hydraulic giant (105), the lower section of described cleaning hydraulic giant (105) is fixedly installed rhone (106).
3. a kind of equipment for making polymer micro needle according to claim 1 it is characterised in that：Described vacuum pumping board
(3) panel and disk body are included, the edge of described panel and disk body sealing are affixed, and described panel is provided with the evacuation of array arrangement
Micropore, a diameter of 0.3mm-2mm of described evacuation micropore, the distance of adjacent evacuation micropore is 0.5mm-5mm；
Described disk body is provided with the airway being interconnected and is connected with evacuation micropore, described airway and vacuum pump (7) phase
Connect, on the panel of described vacuum pumping board (3) place coated substrate (107), described coated substrate (107), vacuum pumping board (3) with
The Absolute truth reciprocal of duty cycle forming vacuum area between vacuum pump (7) is 70kpa to 101kpa.
4. a kind of equipment for making polymer micro needle according to claim 1 it is characterised in that：Described coated substrate
(107) surface is provided with female pattern, and described female pattern is basal diameter or the length of side is less than 1mm and the back taper more than 0.01mm
Shape pattern, the thickness of described coated substrate (107) is 0.3mm-3mm；Described coated substrate (107) has flexibility, breathability
And impermeability, material is silicone rubber or polyurethane material.
5. a kind of equipment for making polymer micro needle according to claim 1 it is characterised in that：Described drying unit
(2) bottom is provided with vent (204), and the wind pushing temperature of described drying unit (2) is 4 degree of -60 degree, described drying unit (2)
The wind speed that air inlet (201) reaches coated substrate (107) surface is 0.2m/s-2m/s.
6. a kind of equipment for making polymer micro needle according to claim 1 it is characterised in that：Described conveyer belt
(5) at least two vacuum pumping board fixed mount (4) on.
7. a kind of equipment for making polymer micro needle according to claim 2 it is characterised in that：Described priming device
(102) liquid injecting mouth is no less than one, and is arranged side by side.
8. a kind of equipment for making polymer micro needle according to claim 7 it is characterised in that：Described priming device
(102) and scraper plate (103) height adjustable.
9. a kind of equipment for making polymer micro needle according to claim 1 it is characterised in that：This equipment also includes
Control system (8), described control system (8) and vacuum pump (7), driving motor (6), blower fan, priming device (102), scraper plate
(103) hydraulic giant (105) and extraction raffinate collecting pipe (104) electrical connection, are rinsed.
10. a kind of equipment for making polymer micro needle according to claim 9 it is characterised in that：This equipment also wraps
Include display system (9), described display system (9) is connected with control system (8), vacuum is controlled by the setting of display system (9)
Pump (7), driving motor (6), blower fan, priming device (102), scraper plate (103), flushing hydraulic giant (105) and extraction raffinate collecting pipe (104)
Motion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610903555.6A CN106426687B (en) | 2016-10-17 | 2016-10-17 | A kind of equipment for making polymer micro needle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610903555.6A CN106426687B (en) | 2016-10-17 | 2016-10-17 | A kind of equipment for making polymer micro needle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106426687A true CN106426687A (en) | 2017-02-22 |
| CN106426687B CN106426687B (en) | 2019-05-10 |
Family
ID=58175984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610903555.6A Active CN106426687B (en) | 2016-10-17 | 2016-10-17 | A kind of equipment for making polymer micro needle |
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| Country | Link |
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| CN (1) | CN106426687B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110038215A (en) * | 2019-04-28 | 2019-07-23 | 广州新济薇娜生物科技有限公司 | Soluble micropin chip production equipment and its production method |
| CN111344131A (en) * | 2017-11-15 | 2020-06-26 | 株式会社Lg生活健康 | Apparatus and process for continuous fabrication of microneedles |
| WO2023004787A1 (en) * | 2021-07-28 | 2023-02-02 | 上海悦肤达生物科技有限公司 | Device and method for preparing microneedle |
| WO2023246262A1 (en) * | 2022-06-21 | 2023-12-28 | 深圳青澜生物技术有限公司 | Method for preparing microneedle drug membrane |
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| CN103301092A (en) * | 2012-03-06 | 2013-09-18 | 中国科学院理化技术研究所 | Polymer micro-needle array chip, and preparation method and application thereof |
| CN105643839A (en) * | 2015-12-24 | 2016-06-08 | 广州新济药业科技有限公司 | Die used for manufacturing microneedle chip and manufacturing method for microneedle chip |
| CN206066797U (en) * | 2016-10-17 | 2017-04-05 | 中国科学院理化技术研究所 | A kind of equipment for making polymer micro needle |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20120193840A1 (en) * | 2011-02-02 | 2012-08-02 | Theraject, Inc. | Method of manufacturing solid solution perforator patches |
| CN103301092A (en) * | 2012-03-06 | 2013-09-18 | 中国科学院理化技术研究所 | Polymer micro-needle array chip, and preparation method and application thereof |
| CN105643839A (en) * | 2015-12-24 | 2016-06-08 | 广州新济药业科技有限公司 | Die used for manufacturing microneedle chip and manufacturing method for microneedle chip |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111344131A (en) * | 2017-11-15 | 2020-06-26 | 株式会社Lg生活健康 | Apparatus and process for continuous fabrication of microneedles |
| CN110038215A (en) * | 2019-04-28 | 2019-07-23 | 广州新济薇娜生物科技有限公司 | Soluble micropin chip production equipment and its production method |
| WO2023004787A1 (en) * | 2021-07-28 | 2023-02-02 | 上海悦肤达生物科技有限公司 | Device and method for preparing microneedle |
| WO2023246262A1 (en) * | 2022-06-21 | 2023-12-28 | 深圳青澜生物技术有限公司 | Method for preparing microneedle drug membrane |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106426687B (en) | 2019-05-10 |
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