CN106390058A - 一种治疗肝硬化、肝腹水、肝结节的中药组合物 - Google Patents

一种治疗肝硬化、肝腹水、肝结节的中药组合物 Download PDF

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CN106390058A
CN106390058A CN201610658870.7A CN201610658870A CN106390058A CN 106390058 A CN106390058 A CN 106390058A CN 201610658870 A CN201610658870 A CN 201610658870A CN 106390058 A CN106390058 A CN 106390058A
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宁国洪
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Abstract

本发明涉及一种治疗肝硬化、肝腹水、肝结节的中药组合物，它包含下列重量份的物质：水牛角6份、柴胡9份、红参9份、茯苓15份、赤芍15份、泽泻15份、木香6份、川牛膝10份、白芍15份、当归15份、香附6份、生白术30份、炙甘草9份、丹皮9份、山药15份、龟板15份、全虫3份、炙首乌15份、郁金12份、三七6份、藏红花6份、干姜3份、蜈蚣3份、山甲3份、炒麦芽15份、夏枯草15份、紫河车6份和煅枯矾1份。本发明所述的中药组合物对肝硬化、肝腹水、肝结节有良好的疗效，无毒副作用。

Description

一种治疗肝硬化、肝腹水、肝结节的中药组合物
技术领域
本发明涉及医药领域，具体来说涉及一种治疗肝硬化、肝腹水、肝结节的中药组合物。
背景技术
肝硬化是一种常见的慢性肝病，可由一种或多种原因引起肝脏损害，肝脏呈进行性、弥漫性、纤维性病变。具体表现为肝细胞弥漫性变性坏死，继而出现纤维组织增生和肝细胞结节状再生，这三种改变反复交错进行，结果肝小叶结构和血液循环途径逐渐被改建，使肝变形、变硬而导致肝硬化。该病早期无明显症状，后期则出现一系列不同程度的门静脉高压和肝功能障碍，直至出现上消化道出血、肝性脑病等并发症死亡。肝缩小、“肝萎缩”是指B超或CT检测，肝脏体积缩小，属于传统医学的“臌胀”。肝硬化往往伴随肝腹水、肝结节。
发明内容
本发明的目的是提供一种治疗肝硬化、肝腹水、肝结节的中药组合物。
为了实现本发明的目的，本发明提供一种治疗肝硬化、肝腹水、肝结节的中药组合物，它包含下列重量份的物质：水牛角6份、柴胡9份、红参9份、茯苓15份、赤芍15份、泽泻15份、木香6份、川牛膝10份、白芍15份、当归15份、香附6份、生白术30份、炙甘草9份、丹皮9份、山药15份、龟板15份、全虫3份、炙首乌15份、郁金12份、三七6份、藏红花6份、干姜3份、蜈蚣3份、山甲3份、炒麦芽15份、夏枯草15份、紫河车6份和煅枯矾1份。
优选地，本发明所述的治疗肝硬化、肝腹水、肝结节的中药组合物还包含：0.2份的具有下列结构式的物质：
优选地，所述中药组合物可以是洗剂、软膏剂或粉剂。
本发明还提供具有下列结构式的物质在制备治疗肝硬化、肝腹水、肝结节的药物中的用途：
优选地，所述药物可以是洗剂、软膏剂或粉剂。
本发明所述的中药组合物对肝硬化、肝腹水、肝结节有良好的疗效，无毒副作用。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例1
称取水牛角6克、柴胡9克、红参9克、茯苓15克、赤芍15克、泽泻15克、木香6克、川牛膝10克、白芍15克、当归15克、香附6克、生白术30克、炙甘草9克、丹皮9克、山药15克、龟板15克、全虫3克、炙首乌15克、郁金12克、三七6克、藏红花6克、干姜3克、蜈蚣3克、山甲3克、炒麦芽15克、夏枯草15克、紫河车6克和煅枯矾1克，粉碎，过100目筛，混合均匀得到粉末。
实施例2
化合物具有下列结构式：
实验例
本发明通过测量乙肝表面抗原HBsAg和乙肝核心抗原HBeAg来评价肝脏功能。
实验器材
检测乙肝表面抗原HBsAg和乙肝核心抗原HBeAg的ELISA试剂盒；孵箱；24孔板。
细胞株
Hep G2的2.2.15细胞株，教育部/卫生部医学分子病毒学重点实验室，上海。
实验药品与试剂
实施例1中制备的粉末；实施例2的化合物；二甲基亚砜；MTT(噻唑蓝)，上海江莱生物科技有限公司；对照药品，拉米呋啶片(3TC)；葛兰素史克制药(苏州)有限公司；细胞培养基DMEM，生长液，配制，其中含10％胎牛血清，380μg/ml G418，0.03％谷胺酰胺，青霉素、链霉素各100μg/ml；
实验方法：
取Hep G2的2.2.15细胞株，以每孔10×105个细胞接种于24孔板，在5％CO2孵箱中37℃培养，48小时后，分别将生长液换成二甲基亚砜助溶的含有实施例1的粉末和实施例2化合物的药物培养液，每组药物培养液设置5个浓度12.5μg/ml～200μg/ml，每个浓度设4个平行孔，继续培养9天，每3天换液一次。阳性对照组药物为拉米呋啶(3TC)，同时以不含药物的培养液作为空白对照组，两个对照组各设置5孔，除生长液相应的换成拉米呋啶药物与不含药物的培养液外，两对照组与药物培养液的操作相同。收集上清液用ELISA试剂盒检测HBsAg及HBeAg含量，同时用MTT测定上述两组药物不同浓度药物对细胞的毒性。其结果见下表。

Claims (5)

1.一种治疗肝硬化、肝腹水、肝结节的中药组合物，其特征在于，它包含下列重量份的物质：水牛角6份、柴胡9份、红参9份、茯苓15份、赤芍15份、泽泻15份、木香6份、川牛膝10份、白芍15份、当归15份、香附6份、生白术30份、炙甘草9份、丹皮9份、山药15份、龟板15份、全虫3份、炙首乌15份、郁金12份、三七6份、藏红花6份、干姜3份、蜈蚣3份、山甲3份、炒麦芽15份、夏枯草15份、紫河车6份和煅枯矾1份。
2.根据权利要求1所述的治疗肝硬化、肝腹水、肝结节的中药组合物，其特征在于，它还包含：0.2份的具有下列结构式的物质：
3.根据权利要求2所述的治疗肝硬化、肝腹水、肝结节的中药组合物，其特征在于，所述中药组合物可以是洗剂、软膏剂或粉剂。
4.具有下列结构式的物质在制备治疗肝硬化、肝腹水、肝结节的药物中的用途：
5.根据权利要求4所述的用途，其特征在于，所述药物可以是洗剂、软膏剂或粉剂。
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CN101745077A (zh) * 2009-09-07 2010-06-23 湖南康普制药有限公司 一种治疗脂肪肝、酒精性肝炎及并发症的中药复方制剂
CN102247559A (zh) * 2011-08-15 2011-11-23 陈光祥 一种治疗急慢性肝病、肝硬化和肝腹水的中药
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CN1265893A (zh) * 2000-01-21 2000-09-13 李井海 软肝消水散
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