CN106389799A - Traditional Chinese medicine preparation for treating primary dysmenorrhea and preparing method and application thereof - Google Patents

Traditional Chinese medicine preparation for treating primary dysmenorrhea and preparing method and application thereof Download PDF

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CN106389799A
CN106389799A CN201610943015.0A CN201610943015A CN106389799A CN 106389799 A CN106389799 A CN 106389799A CN 201610943015 A CN201610943015 A CN 201610943015A CN 106389799 A CN106389799 A CN 106389799A
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chinese medicine
medicine preparation
primary dysmenorrhea
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陈百武
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Huian Taida Business And Commerce Co Ltd
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a traditional Chinese medicine preparation for treating primary dysmenorrhea and a preparing method and application thereof. The traditional Chinese medicine preparation is prepared from, by mass, 6-11 parts of daphniphyllum macropodum leaves, 2-5 parts of rhizoma anemarrhenae, 4-7 parts of concha ostreae, 1-3 parts of the root of three-nerved spicebush and 3-7 parts of lychee exocarp. The preparing method includes the steps that the concha ostreae is soaked with rice wine, dried in the sun, fried and ground, and fine powder is obtained; the rhizoma anemarrhenae, the root of three-nerved spicebush and the lychee exocarp are cleaned and dipped into an ethanol solution for soaking, the mixture is heated and extracted, ethanol is recycled, filtering and concentrating are carried out, and thick paste is obtained; the daphniphyllum macropodum leaves are smashed, mixed and dipped into an ethanol solution and are standing, and supernatant liquid is obtained and concentrated till extract is obtained; the fine powder, the thick paste and the extract are mixed to be even and prepared into tablets, and the traditional Chinese medicine preparation is obtained. According to the traditional Chinese medicine preparation, uterine contraction can be inhibited, pains generated during the menstrual period, before the menstrual period and after the menstrual period can be effectively relieved, the curative effect on primary dysmenorrhea is ideal, and the traditional Chinese medicine preparation takes effects quickly and is free of stimulation to the human body and toxic and side effects on the human body and worthy of application and population into clinic treatment.

Description

A kind of treat Chinese medicine preparation of primary dysmenorrhea as well as preparation method and application thereof
Technical field
The present invention relates to technical field of Chinese medicines, specifically a kind of treat Chinese medicine preparation of primary dysmenorrhea and preparation method thereof And purposes.
Background technology
It is main symptom that dysmenorrhea refers to that women periodicity hypogastralgia before and after menstrual period or its, with other discomforts, so that Impact work and the gynaecopathia of life.China's menalgia sickness rate is 33.19%, is commonly encountered diseases and the frequently-occurring disease of gynecological.Bitterly Through being divided into constitutional and two kinds of Secondary cases, primary dysmenorrhea refers to no pelvic cavity organic disease, mostly primary dysmenorrhea, accounts for dysmenorrhea More than 90%；Secondary dysmenorrhea is the dysmenorrhea that pelvic cavity organic disease causes, and such as endometriosis, pelvic inflammatory disease or cervix uteri are narrow Dysmenorrhea caused by narrow, Intrauterine Foreign Body etc..Primary dysmenorrhea, is mainly in juvenile era, and its pathomechanism may be with endometrium Prostaglandin is relevant.In dysmenorrhea patient uterine's inner membrance and blood, Prostaglandin is higher than normal women.Dysmenorrhea often occur together nausea, Vomiting, diarrhoea, the symptom such as dizzy, weak, severe patient can have pale complexion, be in a cold sweat, and had a strong impact on work and the life of patient Bioplasm amount is it is necessary to active treatment.
Treatment to primary dysmenorrhea at present, adopts non_steroidal anti_inflammatory drug, gonadal hormone, pain relieving spasmolytic, prostatitis more Parathyrine inhibitor for treating, general analgesic effect is strong, but curative effect of short duration it is impossible to radical cure, and have certain toxic and side effects to patient.
Exocarpium Litchi is the outer peel of sapindaceous plant Fructus Litchi, and nature and flavor are bitter, tremble with fear, enter heart channel, have qi-regulating, pain relieving, promote the production of body fluid, Beneficial blood, control excessive thirst, astringent therapy effect, cure mainly dysentery, metrorrhagia, eczema；Stomachache, toothache, traumatic hemorrhage；Gastric abscess, colicky, women Pricking caused by the stagnation of QI and blood etc..
Content of the invention
It is an object of the invention to provide a kind of can suppress uterine contraction, effectively alleviate pain before and after menstrual period and menstrual period, Chinese medicine preparation for the treatment of primary dysmenorrhea having no toxic side effect as well as preparation method and application thereof.
For achieving the above object, the present invention provides following technical scheme：
A kind of Chinese medicine preparation treating primary dysmenorrhea, according to mass fraction meter, is made up of following components：Bean curd leaveves 6～11 Part, 2～5 parts of the Rhizoma Anemarrhenae, 4～7 parts of Concha Ostreae, 1～3 part of the Radix Linderae and 3～7 parts of Exocarpium Litchi.
As the further scheme of the present invention：According to mass fraction meter, it is made up of following components：8～10 parts of bean curd leaveves, 3～4 parts of the Rhizoma Anemarrhenae, 5～6 parts of Concha Ostreae, 1～2 part of the Radix Linderae and 4～6 parts of Exocarpium Litchi.
As the further scheme of the present invention：According to mass fraction meter, it is made up of following components：9 parts of bean curd leaveves, the Rhizoma Anemarrhenae 3 parts, 5 parts of Concha Ostreae, 2 parts of the Radix Linderae and 5 parts of Exocarpium Litchi.
The preparation method of the described Chinese medicine preparation for the treatment of primary dysmenorrhea, comprises the following steps：
（1）Concha Ostreae is immersed yellow wine 3～4 hours, after taking-up, sun dehydration, pour in pot, slow fire parch, after cooling, smash to pieces and grind End, crosses 200～250 mesh sieves, obtains fine powder, standby；
（2）The Rhizoma Anemarrhenae, the Radix Linderae and Exocarpium Litchi are cleaned, the volumetric concentration immersing 3～5 times amount of its quality sum is 82～88% Soak 1～2h, heating extraction 3h in ethanol solution, reclaim ethanol, filter to get filtrate, by gained filtrate concentrate at 65 DEG C relatively Density is 1.12～1.14 thick paste, standby；
（3）Bean curd leaveves are pulverized, mixing, the volumetric concentration immersing 2～4 times amount of its quality is 92～95% ethanol solution, Standing 6～8 hours, takes out the supernatant, is concentrated into the extractum that relative density under room temperature is 1.12～1.14, standby；
（4）By step（1）Fine powder, step（2）Thick paste and step（3）Extractum mix homogeneously, make tablet, as described Treatment primary dysmenorrhea Chinese medicine preparation.
The usage and dosage of the Chinese medicine preparation of described treatment primary dysmenorrhea is：Oral, twice daily, point morning, evening take, Half an hour warm water delivery service after meal, each takes 3g（It is roughly equal to 12g crude drug）.Started continuously to take 7 days in premenstrual 3 days of the moon, this is One menstrual cycle, 2～5 menstrual cycle take effect.
Purposes in the medicine of preparation treatment primary dysmenorrhea for the described Chinese medicine preparation.
Compared with prior art, the invention has the beneficial effects as follows：Formula of Chinese materia medica preparation of the present invention is simple, compatibility is suitable, all Medicine interacts, synergism, can suppress uterine contraction, effectively alleviates the pain before and after menstrual period and menstrual period, for constitutional pain The treatment of warp has an ideal curative effect, instant effect, non-stimulated to human body, have no toxic side effect, and is worth expanded and is applied to In clinical treatment.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, Obviously, described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.Based in the present invention Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of not making creative work, all Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of Chinese medicine preparation treating primary dysmenorrhea, according to mass fraction meter, by following components system Become：6 parts of bean curd leaveves, 5 parts of the Rhizoma Anemarrhenae, 4 parts of Concha Ostreae, 3 parts of the Radix Linderae and 3 parts of Exocarpium Litchi.
The preparation method of the described Chinese medicine preparation for the treatment of primary dysmenorrhea, comprises the following steps：
（1）Concha Ostreae is immersed yellow wine 3 hours, after taking-up, sun dehydration, pour in pot, slow fire parch, after cooling, smash to pieces and grind into powder, Cross 200 mesh sieves, obtain fine powder, standby；
（2）The Rhizoma Anemarrhenae, the Radix Linderae and Exocarpium Litchi are cleaned, the volumetric concentration immersing 3 times amount of its quality sum is 88% ethanol solution Middle immersion 1h, heating extraction 3h, reclaims ethanol, filters to get filtrate, it is 1.12 that gained filtrate is concentrated as relative density at 65 DEG C Thick paste, standby；
（3）Bean curd leaveves are pulverized, mixing, the volumetric concentration immersing 2 times amount of its quality is 95% ethanol solution, standing 6 is little When, take out the supernatant, be concentrated into the extractum that relative density under room temperature is 1.12, standby；
（4）By step（1）Fine powder, step（2）Thick paste and step（3）Extractum mix homogeneously, make tablet, as described Treatment primary dysmenorrhea Chinese medicine preparation.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicine preparation treating primary dysmenorrhea, according to mass fraction meter, by following components system Become：11 parts of bean curd leaveves, 2 parts of the Rhizoma Anemarrhenae, 7 parts of Concha Ostreae, 1 part of the Radix Linderae and 7 parts of Exocarpium Litchi.
The preparation method of the described Chinese medicine preparation for the treatment of primary dysmenorrhea, comprises the following steps：
（1）Concha Ostreae is immersed yellow wine 4 hours, after taking-up, sun dehydration, pour in pot, slow fire parch, after cooling, smash to pieces and grind into powder, Cross 250 mesh sieves, obtain fine powder, standby；
（2）The Rhizoma Anemarrhenae, the Radix Linderae and Exocarpium Litchi are cleaned, the volumetric concentration immersing 5 times amount of its quality sum is 82% ethanol solution Middle immersion 2h, heating extraction 3h, reclaims ethanol, filters to get filtrate, it is 1.14 that gained filtrate is concentrated as relative density at 65 DEG C Thick paste, standby；
（3）Bean curd leaveves are pulverized, mixing, the volumetric concentration immersing 4 times amount of its quality is 92% ethanol solution, standing 8 is little When, take out the supernatant, be concentrated into the extractum that relative density under room temperature is 1.14, standby；
（4）By step（1）Fine powder, step（2）Thick paste and step（3）Extractum mix homogeneously, make tablet, as described Treatment primary dysmenorrhea Chinese medicine preparation.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicine preparation treating primary dysmenorrhea, according to mass fraction meter, by following components system Become：8 parts of bean curd leaveves, 4 parts of the Rhizoma Anemarrhenae, 5 parts of Concha Ostreae, 2 parts of the Radix Linderae and 4 parts of Exocarpium Litchi.
The preparation method of the described Chinese medicine preparation for the treatment of primary dysmenorrhea is same as Example 1.
Embodiment 4
In the embodiment of the present invention, a kind of Chinese medicine preparation treating primary dysmenorrhea, according to mass fraction meter, by following components system Become：10 parts of bean curd leaveves, 3 parts of the Rhizoma Anemarrhenae, 6 parts of Concha Ostreae, 1 part of the Radix Linderae and 6 parts of Exocarpium Litchi.
The preparation method of the described Chinese medicine preparation for the treatment of primary dysmenorrhea is same as Example 2.
Embodiment 5
In the embodiment of the present invention, a kind of Chinese medicine preparation treating primary dysmenorrhea, according to mass fraction meter, by following components system Become：9 parts of bean curd leaveves, 3 parts of the Rhizoma Anemarrhenae, 5 parts of Concha Ostreae, 2 parts of the Radix Linderae and 5 parts of Exocarpium Litchi.
The preparation method of the described Chinese medicine preparation for the treatment of primary dysmenorrhea, comprises the following steps：
（1）Concha Ostreae is immersed yellow wine 4 hours, after taking-up, sun dehydration, pour in pot, slow fire parch, after cooling, smash to pieces and grind into powder, Cross 250 mesh sieves, obtain fine powder, standby；
（2）The Rhizoma Anemarrhenae, the Radix Linderae and Exocarpium Litchi are cleaned, the volumetric concentration immersing 4 times amount of its quality sum is 85% ethanol solution Middle immersion 2h, heating extraction 3h, reclaims ethanol, filters to get filtrate, it is 1.14 that gained filtrate is concentrated as relative density at 65 DEG C Thick paste, standby；
（3）Bean curd leaveves are pulverized, mixing, the volumetric concentration immersing 3 times amount of its quality is 94% ethanol solution, standing 7 is little When, take out the supernatant, be concentrated into the extractum that relative density under room temperature is 1.14, standby；
（4）By step（1）Fine powder, step（2）Thick paste and step（3）Extractum mix homogeneously, make tablet, as described Treatment primary dysmenorrhea Chinese medicine preparation.
Formula of Chinese materia medica preparation of the present invention is simple, compatibility is suitable, and all medicines interact, synergism, can suppress uterine contraction, Effectively alleviate the pain before and after menstrual period and menstrual period, the treatment for primary dysmenorrhea has an ideal curative effect, instant effect is right Human body is non-stimulated, have no toxic side effect, and is worth expanded and is applied in clinical treatment.
First, drug toxicology test
1st, acute toxicity test
With the prepared tablet of the embodiment of the present invention 5 for test, using gastric infusion mode, successive administration 3 times in 24h, every time Interval 4h, administration every time is equivalent to the amount of 16g crude drug, and accumulation medicine total amount reaches 48g crude drug/kg, is equivalent to people's quantity 120 times.In 7d after administration, mice activity, feed, excretion are all normal, well-grown, hair color light, and its average weight is all with reality Test the prolongation of time and increase.Every mice of post mortem at 8d, the perusal heart, liver, spleen, lung, kidney, brain, thymus, stomach, Intestinal etc. does not all find color and paramophia, fails to measure median lethal dose(LD 50)（LD50）.Result shows：Chinese medicine preparation of the present invention is no Acute toxic reaction.
2nd, long term toxicity test
With the prepared tablet of the embodiment of the present invention 5 for test, using gastric infusion mode, Chinese medicine preparation of the present invention is divided into low dose Amount, middle dosage, three groups of high dose, the drug dose of each group is respectively 6,12,24g crude drug/kg/d, be equivalent to clinical dosage 15th, 30,60 times.After gastric infusion 12 weeks, Chinese medicine preparation of the present invention is to the general status of animal, hematological indices, blood biochemical Index all no significantly affects, Systematic anatomy, organ coefficient and histopathological examination also no abnormal pathological change.It is discontinued Also have no within 2 weeks obvious change.Result shows：Chinese medicine preparation of the present invention, in long term toxicity test, does not find that overt toxicity reacts With delayed toxicity reaction.It can be seen that, Chinese medicine preparation non-toxic reaction of the present invention, long-term prescription is safe and reliable.
2nd, pharmacodynamics test
1st, experimental animal：Kunming mouse, body weight 20 ± 2g.
2nd, trial drug dosage：This experiment adopts gastric infusion, and administration group is all provided with high dose group, middle dose group, low dosage Group, the dosage of Chinese medicine preparation of the present invention is respectively 2g/kg, 1g/kg, 0.5g/kg, according to the administration of 10ml/kg body weight；Matched group with Model group：Gavage gives isopyknic water.
3rd, test method：Take Kunming kind female mice 50, be divided into 5 groups by body weight, every group 10, respectively matched group, Model group, Chinese medicine preparation high dose group, Chinese medicine preparation middle dose group, Chinese medicine preparation low dose group.In addition to matched group, remaining each group All according to dosage 0.2mg/ subcutaneous injection diethylstilbestrol 0.2mg/ only, continuous 10 days, to improve uterus sensitivity.In injection hexene Female phenol the 11st day, starts to be administered, for three days on end, after last dose lh, each mice according to dosage 2U/ lumbar injection oxytocin 2U/ Only, record mouse writhing reacts writhing number of times in the incubation period occurring and 30min.
Analgesia rate（%）=（Writhing number of times after writhing number of times-administration before administration）Writhing number of times × 100% before/administration.
Observe rear 30min, put to death mice, peeled off Mouse Uterus, weigh 0.5g with precision instrument, plus 1ml normal saline, Homogenate, centrifugation, take supernatant, to be measured.By mouse prostate element PGF2aEnzyme-linked immunologic detecting kit, mouse prostate element PGE2 The requirement of enzyme-linked immunologic detecting kit carries out PGF2a、PGE2The detection of content.
Experimental result carries out statistical procedures using SPSS 11.0 statistical software, and data is used+ S represents；Compare between each group, Variance then uses variance analyses together, and heterogeneity of variance is then used non parametric testss, had significant difference during P ＜ 0.05.
The impact that Chinese medicine preparation of the present invention induces dysmenorrhea model in mice writhing response to oxytocin is as shown in table 1.With compare Group compares, and the writhing incidence rate of model group gained, writhing are respectively provided with significant difference incubation period（P ＜ 0.05）, show this test Modeling success.Each administration group compared with model group, mouse writhing number of times reduce, writhing prolongation of latency, and each group be respectively provided with aobvious Write sex differernce（P ＜ 0.05）, illustrate that each administration group all has preferable effect to oxytocin induction dysmenorrhea model in mice writhing response, And the increase with dosage, effect is also increasing.
Table 1 each group induces the impact of dysmenorrhea model in mice writhing response to oxytocin
Chinese medicine preparation of the present invention is to mice uterine cancer cell PGF in oxytocin induction dysmenorrhea model in mice2a、PGE2Impact such as table 2 Shown.Compare with matched group, PGF measured by uterine cancer cell for the model group2aContent is higher, has significant difference（P ＜ 0.05）, measured PGE2Content reduces, and has significant difference（P ＜ 0.05）, the above results and this test of analysis shows are made Mould success.PGF compared with model group, in uterine cancer cell for each administration group2aContent is higher, has significant difference（P ＜ 0.05）, PGE2Content reduces, and has significant difference（P ＜ 0.05）, show each administration group to little in oxytocin induction dysmenorrhea model in mice Mus uterine cancer cell PGF2aThe increase of content and PGE2The reduction of content all has remarkable result.
Table 2 each group is to mice uterine cancer cell PGF in oxytocin induction dysmenorrhea model in mice2a、PGE2Impact
In sum, the dysmenorrhea model in mice that each dosage group of Chinese medicine preparation of the present invention induces for oxytocin all has good therapeutic effect, PGF in uterine cancer cell can be increased2aContent, reduces PGE2Content.
3rd, clinical trial
1st, physical data
Choose the patient 400 being diagnosed as primary dysmenorrhea, 15～42 years old age, the course of disease 2 months～10 years, this 400 are suffered from Person is randomly divided into 1～5 group for the treatment of, compares 1～3 group totally eight groups, every group each 50.Patient age between each group and the course of disease compare There was no significant difference, has comparability.
Diagnostic criteria
Diagnostic criteria according to national primary dysmenorrhea clinical speciality meeting：
（1）Sign
Often there is the several months after young woman, menophania in primary dysmenorrhea（6～12 months）Start, under after 30 years old, incidence rate starts Fall, pain often starts appearance before menstruation will be risen or after rising, and continues 48～72h before menstrual phase, and pain is in often Spastic, sometimes very heavy, so that need to lie in bed a few hours or a couple of days, pain concentrates on Ventral Midline, sometimes also with lumbago or put It is incident upon inside stock, the no positive finding of pelvioscopy.
（2）Check
Diagnosing primary dysmenorrhea, the no positive sign of gynecologial examination is the key of diagnosing primary dysmenorrhea, mainly excludes pelvic cavity device The presence that matter sexually transmitted disease (STD) becomes, takes complete medical history, does detailed physical examination（Especially gynecologial examination）, exclude endometrium different Position disease, adenomyosiss, pelvic inflammation etc..
Secretions check, hormonal readiness inspection.
B ultrasonic, peritoneoscope, hysteroscope, hysterosalpingography.
2nd, Therapeutic Method
1～5 group for the treatment of：Take the tablet that embodiment 1～5 is obtained respectively, be administered orally, twice daily, point early, evening takes, after meal half Hour warm water delivery service, each takes 3g（It is roughly equal to 12g crude drug）.Started continuously to take 7 days in premenstrual 3 days of the moon, this is one month Through the cycle, 2～5 menstrual cycle take effect.
Compare 1 group of oral nifedipine piece, 10mg, 3 times/d, the course for the treatment of 7 days, 3 menstrual cycle of the course for the treatment of.
Compare 2 groups：The tablet taken contains only bean curd leaveves, the Rhizoma Anemarrhenae, Concha Ostreae and four kinds of components of the Radix Linderae, remaining and embodiment 5 is identical.Oral, twice daily, point morning, evening take, and half an hour warm water delivery service after meal each takes 3g（It is roughly equal to 12g life Medicine）.Started continuously to take 7 days in premenstrual 3 days of the moon, this is a menstrual cycle, 2～5 menstrual cycle take effect.
Compare 3 groups：The tablet taken contains only a kind of this component of Exocarpium Litchi, and remaining is identical with embodiment 5.It is oral, Twice daily, morning, evening is divided to take, half an hour warm water delivery service after meal, each take 3g（It is roughly equal to 12g crude drug）.Premenstrual 3 days in the moon Start continuously to take 7 days, this is a menstrual cycle, 2～5 menstrual cycle take effect.
3rd, curative effect determinate standard
Cure：After treatment, hypogastralgia and simultaneous phenomenon disappear, and menstrual blood volume color is normal, no clot, continuous 3 menstruation weeks after drug withdrawal Phase no recidivist；
Effective：Suffer from abdominal pain after treatment and substantially mitigate, remaining symptom takes a turn for the better, refuse to obey that analgesic can adhere to work, but can not maintain 3 months More than；
Effectively：After treatment, stomachache mitigates, and remaining symptom takes a turn for the better, and takes analgesic and can adhere to work.
Invalid：After treatment, stomachache and other symptoms have no improvement.
4th, therapeutic outcome
The comparitive study of table 3 each group
Project Case load Cure number Effective number Significant figure Invalid number Cure rate Total effective rate
Treat 1 group 50 28 7 12 3 56% 94%
Treat 2 groups 50 29 9 10 2 58% 96%
Treat 3 groups 50 29 10 8 1 58% 98%
Treat 4 groups 50 30 12 7 1 60% 98%
Treat 5 groups 50 33 13 4 0 66% 100%
Compare 1 group 50 3 12 17 18 6% 64%
Compare 2 groups 50 1 5 13 31 2% 38%
Compare 3 groups 50 0 1 6 43 0% 14%
After the treatment of 2～5 courses for the treatment of, the curative effect of each group is as shown in table 3：The cure rate for the treatment of group is 56～66%, always effectively Rate is 94～100%；Compared with matched group, the cure rate for the treatment of group and total effective rate are far superior to all matched group, and difference has statistics Learn meaning（P ＜ 0.05）, especially treat 5 groups of curative effect and relatively compare the curative effect sum of 2 groups and 3 groups of comparison still to have significance poor Different, illustrate that Exocarpium Litchi has irreplaceable, important effect, Exocarpium Litchi and Chinese medicine system of the present invention in the present invention in medicine preparation In agent, remaining component has obvious synergistic function.And in whole therapeutic process, all there is not obvious adverse reaction in each group.
After treatment end, carry out follow-up to curing patient, follow up time is 3～6 months, treat 1～5 group and 2 groups of comparison Healing person no 1 recurrence, and compare 1 group of healing person and have 1 recurrence.
5th, model case
Case 1：Tang, female, 22 years old, unmarried, dysmenorrhea 5 years, menstrual cycle is normal, and starts abdomen before each menstruation comes Swollen, stomachache, back discomfort, can pain relieving after taking tablet for alleviating pain.Gynecologial examination is not looked into and is seen obvious cause, is diagnosed as on inspection：Former The property sent out dysmenorrhea.Take further consultation after one menstrual cycle of tablet that embodiment 5 is obtained, symptom has taken a turn for the better, and continues to take one month Through the cycle, fully recover, follow-up half a year no recurs.
Case 2：Lee, female, 27 years old, unmarried, lower abdominal distention pain 4 years, once arrived multiple hospitals western medical treatment and interruption is taken Chinese medicine, effect on driving birds is not good.Gynecologial examination is not looked into and is seen obvious cause, is diagnosed as on inspection：Primary dysmenorrhea.Take embodiment 5 to be obtained One menstrual cycle of tablet after further consultation, symptom is clearly better, and continues to take a menstrual cycle, recovery from illness, and follow-up half a year is no multiple Send out.
Case 3：Wang, female, 28 years old, dysmenorrhea 8 years as long as, 3 years unpregnancies of marrying.Patient is from 16 the beginning of the year tides, hypomenorrhea, abdomen The swollen soreness of waist, stomachache weight, appetite of receiving is few, and cold extremities was once taken Chinese medicine and western medicine effect and do not shown.Do not look into through gynecologial examination see substantially former Cause, is diagnosed as primary dysmenorrhea.Take further consultation after two menstrual cycle of tablet that embodiment 5 is obtained, symptom is clearly better, continue Take two menstrual cycle, symptom all disappears, recovery from illness, follow-up half a year does not recur, and pregnancy during follow-up.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie In the case of the spirit or essential attributes of the present invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment only wraps Containing an independent technical scheme, only for clarity, those skilled in the art should for this narrating mode of description Using description as an entirety, the technical scheme in each embodiment can also form those skilled in the art through appropriately combined Understandable other embodiment.

Claims (5)

1. a kind of Chinese medicine preparation treating primary dysmenorrhea is it is characterised in that according to mass fraction meter, be made up of following components： 6～11 parts of bean curd leaveves, 2～5 parts of the Rhizoma Anemarrhenae, 4～7 parts of Concha Ostreae, 1～3 part of the Radix Linderae and 3～7 parts of Exocarpium Litchi.
2. the Chinese medicine preparation for the treatment of primary dysmenorrhea according to claim 1 is it is characterised in that according to mass fraction meter, It is made up of following components：8～10 parts of bean curd leaveves, 3～4 parts of the Rhizoma Anemarrhenae, 5～6 parts of Concha Ostreae, 1～2 part of the Radix Linderae and Exocarpium Litchi 4～6 Part.
3. the Chinese medicine preparation for the treatment of primary dysmenorrhea according to claim 2 is it is characterised in that according to mass fraction meter, It is made up of following components：9 parts of bean curd leaveves, 3 parts of the Rhizoma Anemarrhenae, 5 parts of Concha Ostreae, 2 parts of the Radix Linderae and 5 parts of Exocarpium Litchi.
4. the preparation method of the Chinese medicine preparation according to the arbitrary described treatment primary dysmenorrhea of claims 1 to 3, its feature exists In comprising the following steps：
（1）Concha Ostreae is immersed yellow wine 3～4 hours, after taking-up, sun dehydration, pour in pot, slow fire parch, after cooling, smash to pieces and grind End, crosses 200～250 mesh sieves, obtains fine powder, standby；
（2）The Rhizoma Anemarrhenae, the Radix Linderae and Exocarpium Litchi are cleaned, the volumetric concentration immersing 3～5 times amount of its quality sum is 82～88% Soak 1～2h, heating extraction 3h in ethanol solution, reclaim ethanol, filter to get filtrate, by gained filtrate concentrate at 65 DEG C relatively Density is 1.12～1.14 thick paste, standby；
（3）Bean curd leaveves are pulverized, mixing, the volumetric concentration immersing 2～4 times amount of its quality is 92～95% ethanol solution, Standing 6～8 hours, takes out the supernatant, is concentrated into the extractum that relative density under room temperature is 1.12～1.14, standby；
（4）By step（1）Fine powder, step（2）Thick paste and step（3）Extractum mix homogeneously, make tablet, as described Treatment primary dysmenorrhea Chinese medicine preparation.
5. purposes in the medicine of preparation treatment primary dysmenorrhea for the described Chinese medicine preparation as arbitrary in claims 1 to 3.
CN201610943015.0A 2016-10-26 2016-10-26 Traditional Chinese medicine preparation for treating primary dysmenorrhea and preparing method and application thereof Pending CN106389799A (en)

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CN117695371A (en) * 2024-02-06 2024-03-15 中科创导(山东)生物科技有限公司 Traditional Chinese medicine fermentation preparation for treating dysmenorrhea and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN117695371A (en) * 2024-02-06 2024-03-15 中科创导(山东)生物科技有限公司 Traditional Chinese medicine fermentation preparation for treating dysmenorrhea and preparation method thereof
CN117695371B (en) * 2024-02-06 2024-04-19 中科创导(山东)生物科技有限公司 Traditional Chinese medicine fermentation preparation for treating dysmenorrhea and preparation method thereof

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