CN106389789A - Western medicine composition for preventing and treating acne and preparation method of western medicine composition - Google Patents
Western medicine composition for preventing and treating acne and preparation method of western medicine composition Download PDFInfo
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- CN106389789A CN106389789A CN201611032051.8A CN201611032051A CN106389789A CN 106389789 A CN106389789 A CN 106389789A CN 201611032051 A CN201611032051 A CN 201611032051A CN 106389789 A CN106389789 A CN 106389789A
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Abstract
The invention discloses western medicine composition for preventing and treating acne. The western medicine composition is prepared from raw materials in parts by weight as follows: 5-8 parts of oxytetracycline tablets, 3-5 parts of analgin tablets, 5-8 parts of normal saline, 3-5 parts of compound dexamethasone acetate ointment, 3-10 parts of fluocinonide ointment, 4-6 parts of loratadine tablets, 0.5-2 parts of retinoic acid, 1-3 parts of Xuesaitong tablets, 5-10 parts of bird's nests, 1-3 parts of aloe vera gel, 2-5 parts of miconazole cream, 5-10 parts of sunflower seed oil and 1-3 parts of Amprenavir. The western medicine composition has a synergistic effect through compounding of the raw materials and can effectively inhibit acne growth, promote acne inflammation diminishing and recovery, effectively remove acne marks and promote skin regeneration; furthermore, the western medicine composition adopts the available raw materials, is low in cost, good in curative effect and convenient to apply and has few toxic and side effects; besides, the skin can become fine, smooth and elastic when the western medicine composition is applied to the normal skin.
Description
Technical field
The present invention relates to a kind of Western medicine compound treating comedo, specifically a kind of Western medicine combination of preventing and treating comedo
Thing.
Background technology
Acne is commonly called as comedo, is a kind of pilosebaceous infective inflammation, is opened on follicular orifice sebaceous gland more, once
Follicular orifice blocks, the acne of hyper-proliferative in the stimulation of excess fat acid that excessive sebum metabolism produces and enclosed environment
The effect of propionibacterium, makes skin create inflammatory reaction, therefore the clinical manifestation of small pox from light to be again hoary hair's blackhead,
Inflamed papules and pustule, cyst and tuberosity, and the rubescent small pox with suppuration is with the presence of bacterium infection.Acne is mainly apt to occur in
Teenager, very big to teen-age psychology and social influence, but tend to nature after adolescence and mitigate or fully recover.
Existing Therapeutic Method mainly includes following several:
(1) local topical medicine:Tretinoin (tretinoin emulsifiable paste, Adapalene Gel, Tazarotene gel), benzoyl peroxide
Formyl, antibioticses (clindamycin, erythromycin, chloromycetin etc.), Azelaic Acid, sulfur lotion etc..
(2) oral antibiotic:First-selected Tetracyclines (minocycline, doxycycline etc.), are secondly that Macrolide is (red mould
Element), it is to avoid select to be usually used in the antibiotic such as levofloxacin magnitude for the treatment of system infection.Usual 6~12 weeks of antibiotic regimen.
(3) oral isotretinoin:For serious acne, oral isotretinoin is standard treatment, is also to treat acne at present
Most efficient method.The course for the treatment of is to reach minimum accumulated dose 60mg/kg as target.
(4) anti-androgen therapy:As oral contraceptive Compound Cyproterone Acetate Tablets it is adaptable in women, severe acne
Patient, with the too high performance of androgen levels (as hirsutism, seborrhea etc.) or polycystic ovarian syndrome.Delayed acne and the moon
The female patient that before menstrual period, acne significantly increases also contemplates for applying oral contraceptive.
(5) oral glucocorticoid:It is mainly used in fulminant or acne conglobata, it then follows short-term, low dose and its other party
The principle of method use in conjunction.
(6) other:For the patient not being resistant to or be reluctant to accept Drug therapy it is also contemplated that naturopathy, such as light move
Power therapy (PDT), fruit acid therapy, laser therapy etc..
Existing Therapeutic Method still has that therapeutic effect is poor, the shortcoming for the treatment of cycle length, and some prices are higher, increases
Add the financial burden of people.The medicine of various treatment acnes is also occurred in that on market, but effect is very different, has
There is also serious complication and side effect, have impact on the healthy of people.Therefore, the present invention provides a kind of curative effect
The Western medicine compound good, instant effect, toxic and side effects are little, price is relatively low.
Content of the invention
It is an object of the invention to provide a kind of Western medicine compound of preventing and treating comedo, to solve to carry in above-mentioned background technology
The problem going out.
For achieving the above object, the present invention provides following technical scheme:
A kind of Western medicine compound of preventing and treating comedo, is made up of the raw material of following parts by weight:Hydroxytetracycline tablet 5-8 part, peace
It is nearly piece 3-5 part, normal saline 5-8 part, compound dexamethason acetate emulsifiable paste 3-5 part, fluocinonide cream 3-10 part, chlorine thunder
His stator 4-6 part, Retinoic acid 0.5-2 part, XUESAITONG PIAN 1-3 part, Nidus collocaliae 5-10 part, Aloe glue 1-3 part, miconazole emulsifiable paste 2-5
Part, Oleum Helianthi 5-10 part, amprenavir 1-3 part.
As the further scheme of the present invention:It is made up of the raw material of following parts by weight:6 parts of hydroxytetracycline tablet, analgin tablet
4.5 parts, 7 parts of normal saline, 4 parts of compound dexamethason acetate emulsifiable paste, 4.5 parts of fluocinonide cream, 5 parts of Loratadine Tablets,
1 part of Retinoic acid, 1.5 parts of XUESAITONG PIAN, 8 parts of Nidus collocaliae, 1.5 parts of Aloe glue, 2.5 parts of miconazole emulsifiable paste, 7 parts of Oleum Helianthi, peace Pune
2.5 parts of Wei.
A kind of preparation method of the Western medicine compound of preventing and treating comedo, preparation method is as follows:
A. hydroxytetracycline tablet, analgin tablet, normal saline, compound dexamethason acetate emulsifiable paste, acetic acid are weighed by weight
FUQINGSONG RUGAO, Loratadine Tablets, Retinoic acid, XUESAITONG PIAN, Nidus collocaliae, Aloe glue, miconazole emulsifiable paste, amprenavir and sunflower seed
Oil, standby;
C. hydroxytetracycline tablet, analgin tablet, XUESAITONG PIAN, Loratadine Tablets are pulverized last mix homogeneously, mixed
Close powder;
D. by normal saline, compound dexamethason acetate emulsifiable paste, fluocinonide cream, miconazole emulsifiable paste, Nidus collocaliae, Aloe
Glue, Retinoic acid, amprenavir mix homogeneously, obtain mix paste;
When e. Oleum Helianthi being put into vessel in heating to 30-45 DEG C, by above-mentioned mixed-powder and above-mentioned mix paste
Put into mixing in container, be sufficiently stirred for, ultrasonic vibration 5-10min, obtain final product paste Western medicine compound.
As the present invention further scheme:When Oleum Helianthi is put into vessel in heating to 35 DEG C, by above-mentioned mixing
Powder is put in container with above-mentioned mix paste and is mixed, and is sufficiently stirred for, and ultrasonic vibration 8min obtains final product paste Western medicine compound.
Compared with prior art, the invention has the beneficial effects as follows:
This Western medicine compound passes through raw material and compounds performance synergism, can effectively suppress small pox growth, promote small pox to disappear
Scorching recovery, can effectively remove acne print, promote skin regeneration;And the Western medicine compound of the present invention adopt raw material be easy to get, cost
Low, good effect, smear conveniently, toxic and side effects little;In addition, being applied on normal skin with this Western medicine compound, skin can be made to become
Obtain moist, flexible.
Specific embodiment
With reference to specific embodiment, the technical scheme of this patent is described in more detail.
Embodiment 1
A kind of Western medicine compound of preventing and treating comedo, is made up of the raw material of following parts by weight:5 parts of hydroxytetracycline tablet, An Nai
Nearly 3 parts of piece, 5 parts of normal saline, 3 parts of compound dexamethason acetate emulsifiable paste, 3 parts of fluocinonide cream, 4 parts of Loratadine Tablets,
0.5 part of Retinoic acid, 1 part of XUESAITONG PIAN, 5 parts of Nidus collocaliae, 1 part of Aloe glue, 2 parts of miconazole emulsifiable paste, 5 parts of Oleum Helianthi, amprenavir 1
Part.
A kind of preparation method of the Western medicine compound of preventing and treating comedo, preparation method is as follows:
A. hydroxytetracycline tablet, analgin tablet, normal saline, compound dexamethason acetate emulsifiable paste, acetic acid are weighed by weight
FUQINGSONG RUGAO, Loratadine Tablets, Retinoic acid, XUESAITONG PIAN, Nidus collocaliae, Aloe glue, miconazole emulsifiable paste, amprenavir and sunflower seed
Oil, standby;
C. hydroxytetracycline tablet, analgin tablet, XUESAITONG PIAN, Loratadine Tablets are pulverized last mix homogeneously, mixed
Close powder;
D. by normal saline, compound dexamethason acetate emulsifiable paste, fluocinonide cream, miconazole emulsifiable paste, Nidus collocaliae, Aloe
Glue, Retinoic acid, amprenavir mix homogeneously, obtain mix paste;
When e. Oleum Helianthi being put into vessel in heating to 30 DEG C, above-mentioned mixed-powder is put into above-mentioned mix paste
Mix in container, be sufficiently stirred for, ultrasonic vibration 5min, obtain final product paste Western medicine compound.
Embodiment 2
A kind of Western medicine compound of preventing and treating comedo, is made up of the raw material of following parts by weight:8 parts of hydroxytetracycline tablet, An Nai
Nearly 5 parts of piece, 8 parts of normal saline, 5 parts of compound dexamethason acetate emulsifiable paste, 10 parts of fluocinonide cream, 6 parts of Loratadine Tablets,
2 parts of Retinoic acid, 3 parts of XUESAITONG PIAN, 10 parts of Nidus collocaliae, 3 parts of Aloe glue, 5 parts of miconazole emulsifiable paste, 10 parts of Oleum Helianthi, amprenavir 3
Part.
A kind of preparation method of the Western medicine compound of preventing and treating comedo, preparation method is as follows:
A. hydroxytetracycline tablet, analgin tablet, normal saline, compound dexamethason acetate emulsifiable paste, acetic acid are weighed by weight
FUQINGSONG RUGAO, Loratadine Tablets, Retinoic acid, XUESAITONG PIAN, Nidus collocaliae, Aloe glue, miconazole emulsifiable paste, amprenavir and sunflower seed
Oil, standby;
C. hydroxytetracycline tablet, analgin tablet, XUESAITONG PIAN, Loratadine Tablets are pulverized last mix homogeneously, mixed
Close powder;
D. by normal saline, compound dexamethason acetate emulsifiable paste, fluocinonide cream, miconazole emulsifiable paste, Nidus collocaliae, Aloe
Glue, Retinoic acid, amprenavir mix homogeneously, obtain mix paste;
When e. Oleum Helianthi being put into vessel in heating to 45 DEG C, above-mentioned mixed-powder is put into above-mentioned mix paste
Mix in container, be sufficiently stirred for, ultrasonic vibration 10min, obtain final product paste Western medicine compound.
Embodiment 3
A kind of Western medicine compound of preventing and treating comedo, is made up of the raw material of following parts by weight:6 parts of hydroxytetracycline tablet, An Nai
Nearly 4.5 parts of piece, 7 parts of normal saline, 4 parts of compound dexamethason acetate emulsifiable paste, 4.5 parts of fluocinonide cream, Loratadine Tablets 5
Part, 1 part of Retinoic acid, 1.5 parts of XUESAITONG PIAN, 8 parts of Nidus collocaliae, 1.5 parts of Aloe glue, 2.5 parts of miconazole emulsifiable paste, 7 parts of Oleum Helianthi, peace
2.5 parts of Pune's Wei.
A kind of preparation method of the Western medicine compound of preventing and treating comedo, preparation method is as follows:
A. hydroxytetracycline tablet, analgin tablet, normal saline, compound dexamethason acetate emulsifiable paste, acetic acid are weighed by weight
FUQINGSONG RUGAO, Loratadine Tablets, Retinoic acid, XUESAITONG PIAN, Nidus collocaliae, Aloe glue, miconazole emulsifiable paste, amprenavir and sunflower seed
Oil, standby;
C. hydroxytetracycline tablet, analgin tablet, XUESAITONG PIAN, Loratadine Tablets are pulverized last mix homogeneously, mixed
Close powder;
D. by normal saline, compound dexamethason acetate emulsifiable paste, fluocinonide cream, miconazole emulsifiable paste, Nidus collocaliae, Aloe
Glue, Retinoic acid, amprenavir mix homogeneously, obtain mix paste;
When e. Oleum Helianthi being put into vessel in heating to 35 DEG C, above-mentioned mixed-powder is put into above-mentioned mix paste
Mix in container, be sufficiently stirred for, ultrasonic vibration 8min, obtain final product paste Western medicine compound.
Comparative example 1
A kind of Western medicine compound of preventing and treating comedo, is made up of the raw material of following parts by weight:6 parts of hydroxytetracycline tablet, An Nai
Nearly 4.5 parts of piece, 7 parts of normal saline, 4 parts of compound dexamethason acetate emulsifiable paste, 4.5 parts of fluocinonide cream, Loratadine Tablets 5
Part, 1 part of Retinoic acid, 1.5 parts of XUESAITONG PIAN, 8 parts of Nidus collocaliae, 1.5 parts of Aloe glue, 2.5 parts of miconazole emulsifiable paste, 7 parts of Oleum Helianthi.
A kind of preparation method of the Western medicine compound of preventing and treating comedo, preparation method is as follows:
A. hydroxytetracycline tablet, analgin tablet, normal saline, compound dexamethason acetate emulsifiable paste, acetic acid are weighed by weight
FUQINGSONG RUGAO, Loratadine Tablets, Retinoic acid, XUESAITONG PIAN, Nidus collocaliae, Aloe glue, miconazole emulsifiable paste and Oleum Helianthi, standby;
C. hydroxytetracycline tablet, analgin tablet, XUESAITONG PIAN, Loratadine Tablets are pulverized last mix homogeneously, mixed
Close powder;
D. by normal saline, compound dexamethason acetate emulsifiable paste, fluocinonide cream, miconazole emulsifiable paste, Nidus collocaliae, Aloe
Glue, Retinoic acid mix homogeneously, obtain mix paste;
When e. Oleum Helianthi being put into vessel in heating to 35 DEG C, above-mentioned mixed-powder is put into above-mentioned mix paste
Mix in container, be sufficiently stirred for, ultrasonic vibration 8min, obtain final product paste Western medicine compound.It is not added with amprenavir in comparative example 1.
The theoretical basiss of the present invention are:
Hydroxytetracycline tablet:Indication:Rickettsiosiss, including epidemic typhuses, endemic typhuss, Rocky Mountain
Heat, scrub typhus and Q heat;Mycoplasma Infections;Chlamydia infections, including psittacosis, sexually transmitted disease (STD), lymph granuloma, non-specificity
Urethritiss, salpingitis, cervicitises and trachoma;Relapsing fever;Gibraltar fever;Cholera;Tularemia;The plague;Chancroid.
Analgin tablet:It is mainly used in bringing down a fever, be also used for treating acute arthritises, headache, rheumatic pain, toothache and myalgia
Deng.
Normal saline:Mainly there is antipyretic, antiinflammatory, strengthen the effect such as immune function.
Compound dexamethason acetate emulsifiable paste:For local pruritus, neurodermatitiss, contact dermatitis, seborrheica skin
Inflammation and chronic eczema.
Fluocinonide cream:External is applied to the effective dermatosiss to glucocorticoid, such as contact dermatitis, atopy
Dermatitis, seborrheic dermatitis, eczema, skin prurituss, psoriasises, neurodermatitiss etc. are pruritic and non-infectious inflammation skin
Disease.
Loratadine Tablets:For seasonal or catarrhus perennialises, the urticaria being caused by anaphylactogen and skin scabies
Itch.
Retinoic acid:For treat acne vulgariss, psoriasises, ichthyosiss, lichen planuss, pityriasis rubra pilaris, follicular keratosis,
The disease such as squamous cell carcinoma and melanoma.
XUESAITONG PIAN:Blood circulation promoting and blood stasis dispelling, promotes blood circulation active, suppresses platelet aggregation and increases cerebral blood flow.
Nidus collocaliae:Looks improving and the skin nourishing.
Aloe glue:To incised wound, scratch, suppurating sore, scald, skin prurituss, comedo, black speck, mosquito bite, toothache,
Labial angle festers, operative scar etc. has obvious assosting effect.
Miconazole emulsifiable paste:Miconazole is efficient, safety, broad-spectrum antifungal medicine, nearly all has effect to pathogenic funguses.
Amprenavir:Amprenavir is that a kind of new anti-reflective turns hiv protease inhibitor, has anti-HIV-1 and HIV-2
Albumen enzyme effect, can block protein precursor division, the growth course of viral interference necessary to HIV maturation, then discharge
Immature do not have communicable viruses molecule.There is presently no the application finding amprenavir on treatment comedo.
Oleum Helianthi:Parasite killing can be moisturized, dissipate erysipelas, detumescence poison.
First, this Western medicine compound treats the observation of curative effect of small pox:
Clinical Selection small pox patient of the present invention 400, wherein man 170, female 230;Comedo patient 250, gets angry
Small pox patient 50, physiology phase small pox patient 50, other 50.Small pox symptom is:Redness, pain, pustule, Whiteheads,
Blackhead.Patient is divided into four groups, every group 100, respectively 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment and comparative example
Group.
Application process:1 group of embodiment smears the Western medicine compound of the embodiment of the present invention 1 preparation daily, and 2 groups of embodiment is daily
Smear the Western medicine compound of the embodiment of the present invention 2 preparation, 3 groups of embodiment smears the Western medicine group of the embodiment of the present invention 3 preparation daily
Compound, comparative example group smears the Western medicine compound of comparative example 1 of the present invention preparation daily, 3 times a day, early, middle and late respectively smears one
Secondary, clean after once keeping 15 minutes, be within 3 days a course for the treatment of.
The criterion of therapeutical effect of small pox:Effective, effective and invalid.
(1) effective:After smearing 1 course for the treatment of, small pox symptom is wholly absent, and skin recovers smooth, and no acne print produces, and one
No recur in month;
(2) effective:After smearing 1 course for the treatment of, small pox symptom is clearly better, and small pox redness, pain, pustule disappear, and smear 2
After the course for the treatment of, small pox symptom is wholly absent, and skin recovers smooth, and no acne print produces;
(3) invalid:After smearing the 3-4 course for the treatment of, small pox symptom is no improved or is increased.
Therapeutic outcome is shown in Table 1:
This Western medicine compound of table 1 treats the efficacy result of small pox
Project | Effective/example | Effectively/example | Invalid/example | Effective percentage/% |
1 group of embodiment | 50 | 98 | 2 | 98 |
2 groups of embodiment | 47 | 97 | 3 | 97 |
3 groups of embodiment | 55 | 100 | 0 | 100 |
Comparative example group | 20 | 65 | 35 | 65 |
Small pox can be effectively suppressed to grow, to small pox as it can be seen from table 1 this Western medicine compound passes through interpolation amprenavir
Antiinflammatory recovers to play great role.And this Western medicine compound is respectively provided with higher effective percentage to treating various types of small poxs.
2nd, this Western medicine compound removes the observation of curative effect of acne print:
Clinical Selection patient of the present invention 200, is the acne print that small pox healing is formed;Wherein man 80, female 120.Will
Patient is divided into two groups, i.e. treatment group and matched group, every group of 100 people.
Application process:Matched group smears the Western medicine compound of comparative example 1 preparation daily;It is real that treatment group smears the present invention daily
Apply the Western medicine compound of example 3 preparation, 2-3 time on the one, clean after once keeping 20 minutes, be within 15 days a course for the treatment of.
Remove acne print criterion of therapeutical effect:Effective, effectively and invalid.
(1) effective:After 2 courses for the treatment of of treatment, at acne print, skin is moistened, no depression, projection, no small pox trace, stops treatment
One month afterwards, no recur.
(2) effective:After 3 courses for the treatment of of treatment, at acne print, skin is moistened, and depression boss is inconspicuous, skin-color at acne print
Close to surrounding normal skin, after treating 4 courses for the treatment of, acne print symptom is wholly absent in pool, stops latter month for the treatment of, no recurs.
(3) invalid:After 3 courses for the treatment of of treatment, acne print quality take a favorable turn, but stops symptom after treatment and restore.
Therapeutic outcome is shown in Table 2:
This Western medicine compound of table 2 removes the efficacy result of acne print
Group | Case load | Effective number of cases | Effectively number of cases | Invalid number of cases | Total effective rate |
Matched group | 100 | 25 | 60 | 40 | 60% |
Treatment group | 100 | 55 | 95 | 5 | 95% |
Table 2 shows, the Western medicine compound of the present invention passes through interpolation amprenavir and can be effectively increased the effective of removal acne print
Rate, effective percentage reaches 95%, and this Western medicine compound is a kind of Western medicine compound that safely and effectively can remove acne print.
This Western medicine compound passes through raw material and compounds performance synergism, can effectively suppress small pox growth, promote small pox to disappear
Scorching recovery, can effectively remove acne print, promote skin regeneration;And the Western medicine compound of the present invention adopt raw material be easy to get, cost
Low, good effect, smear conveniently, toxic and side effects little;In addition, being applied on normal skin with this Western medicine compound, skin can be made to become
Obtain moist, flexible.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment party
Formula, in the ken that one skilled in the relevant art possesses, can also be on the premise of without departing from this patent objective
Make a variety of changes.
Claims (4)
1. a kind of Western medicine compound of preventing and treating comedo is it is characterised in that be made up of the raw material of following parts by weight:Hydroxytetracycline tablet
5-8 part, analgin tablet 3-5 part, normal saline 5-8 part, compound dexamethason acetate emulsifiable paste 3-5 part, fluocinonide cream 3-
10 parts, Loratadine Tablets 4-6 part, Retinoic acid 0.5-2 part, XUESAITONG PIAN 1-3 part, Nidus collocaliae 5-10 part, Aloe glue 1-3 part, miconazole
Emulsifiable paste 2-5 part, Oleum Helianthi 5-10 part, amprenavir 1-3 part.
2. the Western medicine compound of preventing and treating comedo according to claim 1 is it is characterised in that former by following parts by weight
Material composition:6 parts of hydroxytetracycline tablet, 4.5 parts of analgin tablet, 7 parts of normal saline, 4 parts of compound dexamethason acetate emulsifiable paste, acetic acid fluorine is light
4.5 parts of loose emulsifiable paste, 5 parts of Loratadine Tablets, 1 part of Retinoic acid, 1.5 parts of XUESAITONG PIAN, 8 parts of Nidus collocaliae, 1.5 parts of Aloe glue, miconazole breast
2.5 parts of cream, 7 parts of Oleum Helianthi, 2.5 parts of amprenavir.
3. a kind of preparation method of the Western medicine compound of described preventing and treating comedo as arbitrary in claim 1-2 it is characterised in that
Preparation method is as follows:
A. hydroxytetracycline tablet, analgin tablet, normal saline, compound dexamethason acetate emulsifiable paste, acetic acid fluorine are weighed by weight light
Loose emulsifiable paste, Loratadine Tablets, Retinoic acid, XUESAITONG PIAN, Nidus collocaliae, Aloe glue, miconazole emulsifiable paste, amprenavir and Oleum Helianthi, standby
With;
C. hydroxytetracycline tablet, analgin tablet, XUESAITONG PIAN, Loratadine Tablets are pulverized last mix homogeneously, obtain mixed powder
End;
D. by normal saline, compound dexamethason acetate emulsifiable paste, fluocinonide cream, miconazole emulsifiable paste, Nidus collocaliae, Aloe glue,
Retinoic acid, amprenavir mix homogeneously, obtain mix paste;
When e. Oleum Helianthi being put into vessel in heating to 30-45 DEG C, above-mentioned mixed-powder is put into above-mentioned mix paste
Mix in container, be sufficiently stirred for, ultrasonic vibration 5-10min, obtain final product paste Western medicine compound.
4. the preparation method of the Western medicine compound of preventing and treating comedo according to claim 3 is it is characterised in that by sunflower seed
When oil puts into vessel in heating to 35 DEG C, above-mentioned mixed-powder is put in container with above-mentioned mix paste and mixes, fully stir
Mix, ultrasonic vibration 8min, obtain final product paste Western medicine compound.
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CN110384744A (en) * | 2019-08-23 | 2019-10-29 | 张彬 | A kind of composition and preparation method treated scytitis and promote wound healing |
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