CN106377719A

CN106377719A - Anti-fever heat-clearing medicinal electuary, and preparation and purpose thereof

Info

Publication number: CN106377719A
Application number: CN201611024397.3A
Authority: CN
Inventors: 林树芳
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-11-22
Filing date: 2016-11-22
Publication date: 2017-02-08

Abstract

The invention provides anti-fever heat-clearing medicinal electuary, and preparation and a purpose thereof, and relates to the technical field of traditional Chinese medicine. The anti-fever heat-clearing medicinal electuary is prepared from the following raw materials including folium isatidis, perilla leaves, radix puerariae, radix angelicae pubescentis, radix bupleuri, areca seed, fructus amomi rotundus, radix scutellariae, radix paeoniae rubra, rhizoma anemarrhenae, cortex magnoliae officinalis, radix platycodi, raw rhubarb, raw liquorice roots, grifola frondosa, stevioside and maltodextrin, and the raw materials are prepared into granule preparations. The traditional Chinese medicine preparation mainly aims at various types of fever such as flu, wind-heat fever, wind-cold fever, wind-damp fever, lung type fever, gastrointestinal fever and cryptogenic type fever; the defects of single action, poor curative effect and the like of the conventional anti-fever traditional Chinese medicine are overcome. The anti-fever heat-clearing medicinal electuary belongs to an ideal traditional Chinese medicine preparation for treating various types of fever.

Description

A kind of antipyretic granule of anti-sense, preparation and application thereof

Technical field

The present invention is the Chinese medicine preparation being related in technical field of traditional Chinese medicines, further, is a kind of antipyretic granule of anti-sense, system Standby and application thereof.

Background technology

At present, both at home and abroad clinically more typically have viral influenza, anemofrigid cold, anemopyretic cold and reason not Bright flu.People obtained flu, took ABC piece, somidon piece, analgin tablet, analgesia piece and general anti-flu before 30 years Medicine all can be cured, and now above-mentioned various medicines are all of no avail, by ability rehabilitation of having an injection, infuse, also do not heard and also do not had Have and saw the medicine appearance cured for influenza, wind sense, thermal sensation energy one medicine.

The present inventor feels the various flu of antipyretic Chongji for Treatment and heating or low fever's clinical experience of existing more than 30 year with anti-, once For treating viral influenza, anemofrigid cold, anemopyretic cold, rheumatic flu, pulmonary type is caught a cold, common cold of gastrointestinal type is all One medicine disease is removed.Viral influenza is throughout the year popular, and during the antipyretic Chongji for Treatment of anti-sense, instant effect, short treating period.Former clinically commonly use Decoction changes system into irregular particle shape, tablet or capsule formulation, promotes and controls it, with general Ji all living creatures.Therefore, research one medicine disease is removed The antipyretic electuary of anti-sense, it is to avoid transfusion of having an injection causes the medicine of probabilistic potential safety hazard to patient, is necessary.

Content of the invention

It is an object of the invention to provide a kind of antipyretic granule of anti-sense, it uses 50: 1 Chinese medicine and extracts concentration Thing makes as raw material, short treating period, good effect, instant effect.

It is an object of the present invention to provide a kind of antipyretic granule of anti-sense, preparation and application thereof, it is by medicine material It is prepared into irregular particle shape, to facilitate patient to take.

A kind of present invention antipyretic granule of anti-sense, preparation and application thereof, is characterized in that realizing by below scheme：

A kind of antipyretic granule of anti-sense, preparation and application thereof, are made up of following component meter feedstock：

Folium isatidis 0.4-0.8 part, perilla leaf 0.4-0.8 part, root of kudzu vine 0.10-0.3 part, levisticum 0.10-0.3 part, radix bupleuri 0.10- 0.3 part, betel nut 0.10-0.13 part, 0.10-0.14 part in one's early teens, root of large-flowered skullcap 0.10-0.14 part, radix paeoniae rubrathe 0.10-0.14 part, the wind-weed 0.10-0.14 part, bark of official magnolia 0.10-0.14 part, balloonflower root 0.04-0.08 part, rhubarb 0.04-0.08 part, licorice 0.04-0.08 Part, grifolan 0.4-0.8 part, steviol glycoside 0.03-0.07 part, maltodextrin 0.1-0.5 part, water 1.0-1.4ml.

Further preferably scheme：It is made up of the raw material that following component measures：

Folium isatidis 0.5-0.7 part, perilla leaf 0.5-0.7 part, root of kudzu vine 0.15-0.25 part, levisticum 0.15-0.25 part, radix bupleuri 0.15-0.25 part, betel nut 0.15-0.25 part, 0.11-0.13 part in one's early teens, root of large-flowered skullcap 0.11-0.13 part, radix paeoniae rubrathe 0.11-0.13 Part, wind-weed 0.11-0.13 part, bark of official magnolia 0.11-0.13 part, balloonflower root 0.05-0.07 part, rhubarb 0.05-0.07 part, licorice 0.05-0.07 part, grifolan 0.5-0.7 part, steviol glycoside 0.04-0.06 part, maltodextrin 0.2-0.4 part, water 1.1- 1.3ml.

Further preferred plan：It is made up of the raw material that following component measures：

0.6 part of folium isatidis, 0.6 part of perilla leaf, 0.2 part of the root of kudzu vine, 0.2 part of levisticum, 0.2 part of radix bupleuri, 0.2 part of betel nut, in one's early teens 0.12 part, 0.12 part of the root of large-flowered skullcap, 0.12 part of the radix paeoniae rubrathe, 0.12 part of the wind-weed, 0.12 part of the bark of official magnolia, 0.06 part of balloonflower root, 0.06 part of rhubarb, raw 0.06 part of Radix Glycyrrhizae, 0.6 part of grifolan, 0.05 part of steviol glycoside, 0.3 part of maltodextrin, water 1.2ml.

The preparation of the present invention, and it is characterized in that being made up of following technique：

1. 120ml water is injected in a resistant to elevated temperatures glass container, add 5 parts of steviol glycoside, 30 parts of maltodextrin, indirectly Water heats 50 DEG C, after stirring makes it all dissolve, in injection one watering can, stand-by；

2. by 60 parts of folium isatidis, 60 parts of perilla leaf, 20 parts of the root of kudzu vine, 20 parts of levisticum, 20 parts of radix bupleuri, 20 parts of betel nut, in one's early teens 12 Part, 12 parts of the root of large-flowered skullcap, 12 parts of the radix paeoniae rubrathe, 12 parts of the wind-weed, 12 parts of the bark of official magnolia, 6 parts of balloonflower root, 6 parts of rhubarb, 6 parts of licorice, grifola frondosus 60 Part.After all mixing, cross 80 mesh sieves, place in electronic granulator, spray steviol glycoside and maltodextrin miscible fluid, side The granulation of spray side, when medicinal powder is in irregular particle shape, takes out, puts in electric hot-air drying box, is dried 4 little under 60 DEG C of environment When -5 hours, whne drug particles water content be less than 6% when, take out, use 40W ultraviolet sterilizing lamp, carry out surface sterilizing 1 hour, With 1.86 parts of dosage of every pouch, load vacuum seal in aluminium foil bag,.

The metering of above-mentioned each component is the dosage of 1 day 2 times clothes, for convenience of making, each medicine can be pressed 100 times, 1000 times 10000 times or 100000 times of ratio metering increases.The preparation of the present invention, technique are 100 times of mark systems by component metering.

Folium isatidis in the present invention, bitter, property Great Cold.Enter the heart, stomach.There is clearing heat and detoxicating, blood cooling and ecchymoses removing effect.Right Eruption caused by warm disease, pestilence, heat toxin, go out spot, aphthae, abscess of throat, unconsciousness due to high fever have preferable therapeutic action.This Product have antiviral and kill leptospiral effect.For staphylococcus aureus, staphylococcus albus, alpha streptococcus, Meningococcus, Diplococcus pneumopniae etc. have good inhibiting effect, have significant effect for treatment encephalitis, parotitis, influenza.

Perilla leaf in the present invention, taste is pungent, warm in nature, enter lung channel.There is relieving exterior syndrome and dispelling cold, in promoting the circulation of qi width, the effect of sending down abnormally ascending dissolving phlegm. Play the role of to detoxify well dissipates cold to catching cold.

The root of kudzu vine in the present invention, radix bupleuri, there is relieving muscles diaphoresis, invigorating vital function and promoting eruption, reducing fever by reconciliation, soothing liver-qi stagnation, clearing heat and promoting fluid Effect.Wherein the root of kudzu vine contains flavonoids and starch, and only heat-clearing is not also hypoglycemic, the effect of step-down, can have and improve brain and follow Ring and the effect of peripheral circulation.Radix bupleuri contains saponin, has calmness, analgesic effect, and has anti-liver injury, prevents fat lesion And fibroplasia, reduce transaminase and the effect of cholagogic.

Levisticum in the present invention, has wines used as antirheumatic, an effect that pain relieving is induced sweat.For the headache caused by catching cold, aversion to cold The diseases such as heating, physical distress, more have, to the myalgia of waist, knee, sufficient shin, the effect solely seen.Also there is antirheumatic, analgesia, expansion Blood vessel, hypotensive etc. effect.

Betel nut in the present invention, has functions that desinsection, the long-pending, promoting the circulation of qi of disappearing, Li Shui.

In the present invention in one's early teens, also known as tsaoko, its pungent fragrance, property is gentle.Have eliminating dampness dispelling cold, warm stomach invigorating the spleen, Pain relieving eliminating the phlegm, the function of lower gas removing toxic substances, have appetizing, digestion and appetitive effect again.

The root of large-flowered skullcap in the present invention, heat-clearing and damp-drying drug, purging intense heat and detonicating；Radix paeoniae rubrathe clearing heat and cooling blood, blood stasis removing analgesic；Wind-weed purging intense heat relieving restlessness, Nourshing Yin and drynsessmoistening prescription；Bark of official magnolia promoting qi circulation to remove dampness, fall are breathed heavily against dry；Balloonflower root is opened a surname's lung qi, is gone phlegm apocenosis；Rhubarb attacks poison, clearing heat-fire under rushing down, Promoting blood circulation, removing toxic substances disappears effect of pain；Licorice is clearing heat and detoxicating, invigorate the spleen and benefit qi, moisten the lung and relieve the cough, relieving spasm to stop pain, mediation property of medicine Effect.

Grifolan in the present invention, tests through the chemistry over nearly 10 years, nutrition and pharmaceutical research and finds, ash tree Polysaccharide β-(1-3)-D- glucan is contained, in 140KDa, grifolan has significantly antitumor, anti-its middle-molecular-weihydroxyethyl in spending Inhibition of HIV, improves function of immune system, adjusts blood sugar, blood fat and cholesterol levels, the effect such as hypotensive.To preventing cancer cell Generate and transfer, AIDS, hypertension, obesity, diabetes and immune system dysfunction, have certain curative effect.Cause This add grifolan opposing influenza virus, inhibition of HIV are played the role of to the invasion and attack of human body good.

Steviol glycoside in the present invention, is the product that Shandong Yikang Group Co., Ltd produces, is to be carried using stevia rebaudianum cured leaf Take the product of concentration, be a kind of not sugary sweetener, zero calory, it is not involved in metabolism of blood glucose, execution standard is GB8270- 2014.So it is suitable for the high common cold crowd of blood sugar is taken.

In the present invention, other medicines can each medicine enterprise and biotech company be bought at home, and equipment etc., temporarily unknown Claim and model, the output according to manufacturing enterprise and standard can be bought by oneself.

Medicine material in the present invention is all 50: 1 extraction concentrat, and its beneficial aspects is slight bitter, micro- sweet, side of taking Just.Outstanding behaviours is：Short treating period, instant effect, good effect, have no side effect.

The present invention is through clinical nearly 5000 many cases experimental verifications in more than 30 years it was demonstrated that have the treatment that a medicine disease is removed to various flu Effect, by influenza viral to 5000 many cases, chill, rheumatism, anemopyretic cold, pulmonary type flu, stomach sexuality emit and The flu that unknown cause causes, Ureteral Calculus, total effective rate reaches 100%.Below by way of clinical observation on the therapeutic effect experiment, explain further State the beneficial effect of medicine of the present invention.

Experimental data：

1. the various flu caught a cold or cause because of other diseases；

2. case statistics：Treat 5000 within 1986-2016 years, the male sex 2460 in patient, women 2540.Age divides Cloth is：Less than 10 years old 1490,11 years old -20 years old 920,21 years old -30 years old 683,31 years old -40 years old 612,41 years old -50 years old 725 Example, 51 years old -60 years old 376, more than 61 years old 194.Max age 88 years old, minimal ages 2 years old half.Wherein viral popular sexuality Emit 1396, anemofrigid cold 920, rheumatic is caught a cold 615, anemopyretic cold 890, and pulmonary type is caught a cold 430, and stomach is sexy Emit 528, the flu 221 that reason is failed to understand or other diseases cause.

3. treatment method：Adult takes 2 times daily, point early, late 2 aftermealses, 1 pouch/1.86 part every time, minor Consumption halves, more than two years old children's consumption 1/3.

4. efficacy assessment standard：

Cure：Cough, heating or low-heat, nasal obstruction or rhinorrheas, each joint is ached of whole body, bitter taste, stool are dry, urine Huang, The weary powerless, clinical symptom disappearance such as appetite is not good enough, dizziness headache, sternal rib are bitter full of pain in the back, body, experimental index recovers normal, no multiple Send out；

Effectively：Clinical items symptom takes a turn for the better, and experimental index improves；

Invalid：Clinical symptoms and experimental index are unchanged；

5. therapeutic effect：

Treat 5000 altogether, merging total effective rate is 100%, and wherein viral influenza cures 1390, accounts for 27.8%；Effective 6, account for 0.012%；Anemofrigid cold cures 920, accounts for 18.4%；Rheumatic flu cures 614, accounts for 12.28%；Effective 1, account for 0.002%；Anemopyretic cold cures 890, accounts for 17.8%；Pulmonary type flu cures 426, accounts for 8.5%；Effective 4, account for 0.008%；Stomach sexuality emits healing 520, accounts for 10.4%；Effective 8, account for 0.016%；Reason is not The flu that bright or other diseases cause cures 215, accounts for 4.3%, effective 6, accounts for 0.012%, total effective rate reaches 100%.

6. clinical typical treatment case：

1. Chen, man, 78 years old, in December, 1989 was prostatitis through disasters in Jianping County, Liaoning hospital diagnosis, 1 month disease for the treatment of Feelings increase, gradually to little hematuria, urethra pain, and finally result in urinary obstruction, the urine being derived with catheter is scarlet, by Chinese and Western The treatment of doctor is not still felt any better, and March nineteen ninety leaves hospital, and asks the present invention to treat, 83 times/min of pulse, bitter taste, and tongue has white tongue, appetite Depressed, sometimes cold and sometimes hot, body is weary powerless, and radix penis part has occlusive to keenly feel.According to the symptom such as patient's bitter taste, tongue fur be white, it is diagnosed as Influenza.Its prostate is triggered by diseases caused by external factors, first controls diseases caused by external factors by the treatment rule of the traditional Chinese medical science, after control chronic ill, give the present invention resist Feel antipyretic electuary, take daily 2 times, 1 pouch/1.86 part every time, take 2 days, conscious clinical symptoms halve, give 3 days again Consumption and heal.

2. Wu, man, 86 years old, already near seventy, in September, 1992, suffer from influenza, 39.2 DEG C of high fever, have an injection transfusion through hospital of township Do not feel any better within 10 days, after treated by the present inventor, 90 times/min of its arteries and veins, dry is not intended to drink, and tongue fur is white, but mouth is not bitter, and the whole body is each Joint is ached, pain in the back, stool are dry, urine is yellow, give the present invention the antipyretic electuary consumption of 2 days of anti-sense, high fever is moved back, and gives 2 days again Dose cure.

3. Lee, man, 49 years old, 39 DEG C of cat fever, take anticold etc. anti-sense medicine invalid, after 3 days, transfusion of having an injection of being admitted to hospital Still do not feel any better within 7 days, fully recover after taking the present invention antipyretic electuary of anti-sense 4 days.

4. neat certain, man 31 years old, wife, 30 years old, daughter 2 years old half, the whole family suffers from influenza, takes various anti-sense medicines and does not feel any better, warp Take the present invention antipyretic electuary of anti-sense 2 days, every symptom halves, the consumption that 1/3 bag of child's consumption, serve on 4 days, and the whole family cures.

5. 1 son of Liu 5 years old, daughter all suffers from influenza for 3 years old, and heating is light, cough weight, poor appetite, and tongue fur is white, and mouth is not Hardship,, arteries and veins 90 time/min invalid with several pectoral, cures after taking the present invention antipyretic electuary of anti-sense 2.

6. Wang, female, 46 years old, Yishui County in Shandong Province Gao Zhuan town peasant, doctor examines as icteric hepatitis, high fever 40 within 2009 DEG C, it is admitted to hospital to treat 5 days and does not move back, hospital makes it transfer from one hospital to another, go home because of financial difficulties at that time to ask our to treat, 90 times/min of its arteries and veins, Skin cadmium yellow, tongue fur four edge margin, middle yellow, bitter taste, Muscular stiffness, stool is dry, and urine is red-black, feels antipyretic punching with the present invention is anti- Agent, after 2 days, high fever is moved back, and Huang moved back on 4th, and whole body on the 5th is brisk and heals.

7. the daughter of Zhang, 26 years old, 39 DEG C of postpartum high fever, constantly, patient and his family county hospital gynemetrics please cure mainly doctor to uterine hemorrhage Teacher pays a home visit, and is diagnosed as functional uterine bleeding, is no imitated greatly within 3 months with Chinese and Western medicine partner treatment, small amount bleeding does not stop, drug withdrawal bleeding Increase, patient's tongue fur is white, mouth slight bitter, 96 times/min of arteries and veins number, general malaise, slight chill.This is because influenza disease is protopathy, Uterine hemorrhage belongs to secondary disease, is courageously to be felt blood after antipyretic electuary 2 days and stopped with the present invention is anti-, but arteries and veins number is still in 95-97 time/min, and Give 2 feed ration medicines, appetite has taken a turn for the better, but still has taediumvitae, give 2 feed ration recoveries from illness, the dose of 6 days returns to normal altogether again.

8. military certain, female, 40 years old, because severe headache is admitted to hospital, Yinan county hospital, invalid with various antalgesics, suspection is brain tumor, Suggestion turns Linyi City hospital therapy, because patient can not ride, fears operation again, and treatment of being in of leaving hospital, resist through taking the present invention Feel antipyretic electuary 1 feed ration, headache sense mitigates, give 3 feed ration recoveries from illness again.

9. solve certain, female, 11 years old, toothache was acutely, neither very warm nor cold, and bitter taste tongue is white, Muscular stiffness, gave the anti-sense of the present invention antipyretic The toothache sense of electuary 2 feed ration disappears, and cures.

10. the son of Dong, 21 years old, goes home to celebrate the New Year or the Spring Festival from Tianjin manual labour in December, 1989, and next day fever stupor, through local township Town hospital diagnosis are ileotyphus disease, take traditional Chinese medicine 6 doses, and injection chloramphenicol 4 days is invalid, white according to bitter taste tongue, by influenza therapy, take The present invention antipyretic electuary of anti-sense burns and moves back on the 3rd, and god is clear, takes recovery from illness on the 2nd again.

Specific embodiment

Below in conjunction with embodiment, embodiment of the present invention is described in detail, but makes those of skill in the art Will readily appreciate that, the following examples are merely to illustrate the present invention, and be not construed as limiting the scope of the present invention, do not note in embodiment Bright actual conditions, the condition according to normal condition or manufacturer's suggestion is carried out.The unreceipted production of agents useful for same, instrument and equipment Manufacturer person, all can be by the commercially available conventional products bought and obtain.

Embodiment 1

Embodiment 2

Embodiment 3

Embodiment 4

Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's In the case of spirit and scope, many other changes can be made and change.Therefore, also imply that in claims Include belonging to all such changes and modifications in the scope of the invention.

Claims

1. a kind of antipyretic granule of anti-sense is it is characterised in that be made up of the raw material that following component measures：

Folium isatidis 0.5-0.7 part, perilla leaf 0.5-0.7 part, root of kudzu vine 0.15-0.25 part, levisticum 0.15-0.25 part, radix bupleuri 0.15- 0.25 part, betel nut 0.15-0.25 part, 0.11-0.13 part in one's early teens, root of large-flowered skullcap 0.11-0.13 part, radix paeoniae rubrathe 0.11-0.13 part, the wind-weed 0.11-0.13 part, bark of official magnolia 0.11-0.13 part, balloonflower root 0.05-0.07 part, rhubarb 0.05-0.07 part, licorice 0.05-0.07 Part, grifolan 0.5-0.7 part, steviol glycoside 0.04-0.06 part, maltodextrin 0.2-0.4 part, water 1.1-1.3ml.

2. according to right 1 requires a kind of anti-sense antipyretic granule it is characterised in that be by following component measure former Material is made：

Folium isatidis 0.4-0.8 part, perilla leaf 0.4-0.8 part, root of kudzu vine 0.10-0.3 part, levisticum 0.10-0.3 part, radix bupleuri 0.10-0.3 Part, betel nut 0.10-0.13 part, 0.10-0.14 part in one's early teens, root of large-flowered skullcap 0.10-0.14 part, radix paeoniae rubrathe 0.10-0.14 part, the wind-weed 0.10-0.14 part, bark of official magnolia 0.10-0.14 part, balloonflower root 0.04-0.08 part, rhubarb 0.04-0.08 part, licorice 0.04-0.08 Part, grifolan 0.4-0.8 part, steviol glycoside 0.03-0.07 part, maltodextrin 0.1-0.5 part, water 1.0-1.4ml.

3. according to right 2 requires a kind of anti-sense antipyretic granule it is characterised in that be by following component measure former Material is made：

0.6 part of folium isatidis, 0.6 part of perilla leaf, 0.2 part of the root of kudzu vine, 0.2 part of levisticum, 0.2 part of radix bupleuri, 0.2 part of betel nut, in one's early teens 0.12 Part, 0.12 part of the root of large-flowered skullcap, 0.12 part of the radix paeoniae rubrathe, 0.12 part of the wind-weed, 0.12 part of the bark of official magnolia, 0.06 part of balloonflower root, 0.06 part of rhubarb, licorice 0.06 part, 0.6 part of grifolan, 0.05 part of steviol glycoside, 0.3 part of maltodextrin, water 1.2ml.

4. the one kind according to any one of claim 1-3 is anti-feels antipyretic granule, preparation method it is characterised in that wrapping Include following processing step：

120ml water is injected in a resistant to elevated temperatures glass container, adds 5 parts of steviol glycoside, 30 parts of maltodextrin, a water receiving is heated 50C °, after stirring makes it all dissolve, in injection one watering can.

5. one kind according to claim 4 is anti-feels antipyretic granule, preparation method it is characterised in that including following work Skill step：

By 60 parts of folium isatidis, 60 parts of perilla leaf, 20 parts of the root of kudzu vine, 20 parts of levisticum, 20 parts of radix bupleuri, 20 parts of betel nut, 12 parts in one's early teens, the root of large-flowered skullcap 12 parts, 12 parts of the radix paeoniae rubrathe, 12 parts of the wind-weed, 12 parts of the bark of official magnolia, 6 parts of balloonflower root, 6 parts of rhubarb, 6 parts of licorice, 60 parts of grifola frondosus.All mix After closing uniformly, cross 80 mesh sieves, place in electronic granulator, spray steviol glycoside and maltodextrin miscible fluid, granulate in spray, When medicinal powder is in irregular particle shape, takes out, put in electric hot-air drying box, be dried 4 hours -5 hours under 60C ° of environment, treat When drug particles water content is less than 6%, takes out, use 40W ultraviolet sterilizing lamp, carry out surface sterilizing 1 hour, with every pouch 1.86 The dosage of part, loads vacuum seal in aluminium foil bag.