CN106377563A - Pharmaceutical composition for treating chronic pharyngitis - Google Patents
Pharmaceutical composition for treating chronic pharyngitis Download PDFInfo
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- CN106377563A CN106377563A CN201611010578.0A CN201611010578A CN106377563A CN 106377563 A CN106377563 A CN 106377563A CN 201611010578 A CN201611010578 A CN 201611010578A CN 106377563 A CN106377563 A CN 106377563A
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- pharmaceutical composition
- chronic pharyngitis
- treating chronic
- hypericin
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- 201000007100 Pharyngitis Diseases 0.000 title claims abstract description 58
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 36
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims abstract description 19
- 229960003022 amoxicillin Drugs 0.000 claims abstract description 19
- BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229940005608 hypericin Drugs 0.000 claims abstract description 19
- PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 claims abstract description 19
- SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 claims abstract description 19
- UYUXSRADSPPKRZ-SKNVOMKLSA-N D-glucurono-6,3-lactone Chemical compound O=C[C@H](O)[C@H]1OC(=O)[C@@H](O)[C@H]1O UYUXSRADSPPKRZ-SKNVOMKLSA-N 0.000 claims abstract description 18
- 229950002441 glucurolactone Drugs 0.000 claims abstract description 18
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 18
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 18
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims abstract description 14
- 235000013923 monosodium glutamate Nutrition 0.000 claims abstract description 14
- 229940073490 sodium glutamate Drugs 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 12
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 claims description 17
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 claims description 17
- 235000010081 allicin Nutrition 0.000 claims description 17
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 claims description 16
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 229910021642 ultra pure water Inorganic materials 0.000 claims description 7
- 239000012498 ultrapure water Substances 0.000 claims description 7
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 6
- 229910052737 gold Inorganic materials 0.000 claims description 6
- 239000010931 gold Substances 0.000 claims description 6
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 5
- 229910052709 silver Inorganic materials 0.000 claims description 5
- 239000004332 silver Substances 0.000 claims description 5
- 244000170916 Paeonia officinalis Species 0.000 claims description 2
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 2
- 229930182470 glycoside Natural products 0.000 claims description 2
- 150000002338 glycosides Chemical class 0.000 claims description 2
- 240000002234 Allium sativum Species 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 239000012467 final product Substances 0.000 claims 1
- 235000004611 garlic Nutrition 0.000 claims 1
- 230000001154 acute effect Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 241000205585 Aquilegia canadensis Species 0.000 abstract description 2
- 208000016150 acute pharyngitis Diseases 0.000 abstract description 2
- 241001122767 Theaceae Species 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 210000003800 pharynx Anatomy 0.000 description 13
- 208000024891 symptom Diseases 0.000 description 8
- 230000001684 chronic effect Effects 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 244000025254 Cannabis sativa Species 0.000 description 6
- SNGZVXPRGLTKNU-RGMNGODLSA-N [Na].C(CC)N[C@@H](CCO)C(=O)O Chemical compound [Na].C(CC)N[C@@H](CCO)C(=O)O SNGZVXPRGLTKNU-RGMNGODLSA-N 0.000 description 5
- 210000004400 mucous membrane Anatomy 0.000 description 5
- 230000028327 secretion Effects 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 4
- 208000037976 chronic inflammation Diseases 0.000 description 4
- 230000006020 chronic inflammation Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 206010028813 Nausea Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 206010065716 Pharyngeal inflammation Diseases 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- 208000027744 congestion Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000003563 lymphoid tissue Anatomy 0.000 description 2
- 230000008693 nausea Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 241000321096 Adenoides Species 0.000 description 1
- -1 Aldehyde lactone Chemical class 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 206010070245 Foreign body Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000005206 Laryngopharyngeal Reflux Diseases 0.000 description 1
- 208000001705 Mouth breathing Diseases 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010061926 Purulence Diseases 0.000 description 1
- 206010067869 Reflux laryngitis Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047675 Vocal cord polyp Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 210000002534 adenoid Anatomy 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002388 eustachian tube Anatomy 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000002390 hyperplastic effect Effects 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000003695 paranasal sinus Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 208000014515 polyp of vocal cord Diseases 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 230000001755 vocal effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a pharmaceutical composition for treating chronic pharyngitis. The pharmaceutical composition for treating chronic pharyngitis is prepared from the following main raw materials in parts by weight: 15-20 parts of tea polyphenol, 8-14 parts of sodium glutamate, 14-22 parts of garlicin, 10-15 parts of amoxicillin, 2-8 parts of glucurolactone, 4-10 parts of penoniflorin, 2-4 parts of hypericin and 5-10 parts of honeysuckle flower extract. The pharmaceutical composition has favorable regulation and treatment effects on various types of chronic pharyngitis, and can basically cure the acute and chronic pharyngitis.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of pharmaceutical composition for treating chronic pharyngitis.
Background technology
Chronic pharyngitis is pharynx mucous membrane, under mucous membrane and adenoid chronic inflammation.Diffusivity pharyngeal inflammation is often upper breathing
A part for road chronic inflammation；Limitation pharyngeal inflammation mostly then is pharynx lymphoid tissue inflammation.Chronic pharyngitis is common in clinic, disease
Journey is long, the easy recurrent exerbation of symptom.Chronic pharyngitis is more common in adult, and children also may occur in which.Constitutional symptom is all inconspicuous, with office
Based on portion's symptom.Various chronic pharyngitis symptom is substantially similar and varied, such as pharyngeal sense of discomfort, foreign body sensation, pharyngeal secretion
Be difficult to bring up, pharyngeal gargalesthesia, burn feeling, dry sensation or excitement, also can have hypodynia sense.Because pharynx rear wall is generally because pharyngeal chronic
Inflammation causes more sticky secretion adhesion, and because nose, nasal sinus, nasopharynx pathological changes cause night mouth breathing, Chang Chen rises
When irritable cough and nausea occur.Because foreign body in pharynx sense can behave as frequently swallowing.Pharyngeal secretion is few and is difficult expectoration
Person often shows as habitually dry cough and expectoration action of clearing one's throat, if firmly cough or clear one's throat to cause pharyngeal mucosa hemorrhage,
Cause to carry blood in secretion.From pathology, chronic pharyngitis can be divided into following 5 classes：1) chronic simple pharyngitis：Check visible pharynx
Mucous membrane chronic congestion, thin vessels varicose, in kermesinus, there is sticky secretion on a small quantity on surface.2) chronic hypertrophic pharyngitis：Pharyngeal inspection
Look into visible pharynx rear wall multiple graininess folliculus protuberance, in chronic congestion shape, sometimes combine together, on the top of lymph particle protuberance
Portion can form cryptomere white point, visible yellow-white exudate during ulceration, and lateral pharyngeal band lymphoid tissue can thicken in streak.3) chronic wither
Contracting pharyngitis or chronic pharyngitis sicca：Pharyngeal with dry scab, with halitosis.Inspection is shown in that pharynx mucous membrane is dry, poor, and severe one is in squama
Shape, shinny.Purulence can be covered and do scab, pathology is extended to Eustachian tube and can cause tinnitus, dysacousis.Spread to throat, can cause
Hoarseness.4) reflux sphagitis：Pharyngeal training is had a medical check-up same chronic simple and hyperplastic pharyngitis, and Laryngopharyngeal reflux may be with
Vocal nodule, polyp of vocal cord and trachyphonia occurs.Above-mentioned symptom Chang Yong throat is excessive, abrupt change of climate, environment temperature and humidity change
Shi Jiachong, especially with atrophic and pharyngitis sicca for writing.Chronic pharyngitis had not only belonged to disease but also had belonged to sub-health state, ill
Rate, anti-a rate are high.Generally, it is considered that chronic pharyngitis is pharynx mucous membrane chronic inflammation, how because of acpuei pharyngitis recurrent exerbation or treatment not
Thoroughly, and adjacent organs focus stimulates as nasosinusitis, tonsillitis, nasopharyngitis, tracheitis etc. cause, but tobacco and wine excessively, raw
Work irregular, fatigue, dust invade and pernicious gas stimulates, be in for a long time in air pollution environmental be also common disease because.
Therefore, it is badly in need of researching and developing a kind of suitable good effect, speed is fast, price is low, the CD that has no toxic side effect.
Content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for treating chronic pharyngitis, to solve above-mentioned background skill
The problem proposing in art.
For achieving the above object, the present invention provides following technical scheme：
A kind of pharmaceutical composition for treating chronic pharyngitis, the primary raw material according to weight portion is：Tea Polyphenols 15-20
Part, sodium glutamate 8-14 part, allicin 14-22 part, amoxycillin 10-15 part, Glucurolactone 2-8 part, Paeoniflorin 4-10
Part, hypericin 2-4 part, Honegsukle flower P.E 5-10 part.
As the further scheme of the present invention：The described pharmaceutical composition for treating chronic pharyngitis, according to weight portion
Primary raw material is：Tea Polyphenols 16-18 part, sodium glutamate 10-13 part, allicin 16-20 part, amoxycillin 11-13 part, Portugal
Aldehyde lactone 3-7 part, Paeoniflorin 5-9 part, hypericin 2-4 part, Honegsukle flower P.E 5-10 part.
As the further scheme of the present invention：The described pharmaceutical composition for treating chronic pharyngitis, according to weight portion
Primary raw material is：17 parts of Tea Polyphenols, 12 parts of sodium glutamate, 18 parts of allicin, 12 parts of amoxycillin, 5 parts of Glucurolactone, Chinese herbaceous peony
7 parts of medicine glycosides, 3 parts of hypericin, 8 parts of Honegsukle flower P.E.
A kind of preparation method of the pharmaceutical composition for treating chronic pharyngitis, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Tea Polyphenols, sodium glutamate, allicin, amoxycillin green grass or young crops are weighed by above-mentioned metering ratio
Mycin, Glucurolactone, Paeoniflorin, hypericin, Honegsukle flower P.E, sieve, and machinery adds ultra-pure water after mixing, and places pharmacy
In mixer, mix 4-8min, control RSD≤5%, compressing tablet low temperature drying after mixing, at 4-8 DEG C, packaging is temperature control
Must be used for treating the pharmaceutical composition of chronic pharyngitis.
As the further scheme of the present invention：6min is mixed in concrete steps.
As the further scheme of the present invention：In concrete steps, temperature control is at 6 DEG C.
Compared with prior art, the invention has the beneficial effects as follows：
The medicine of present invention preparation is respectively provided with good conditioning and therapeutic effect for various types of chronic pharyngitis, can
Fundamentally cure acute/chronic pharyngitis.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of not making creative work, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of pharmaceutical composition for treating chronic pharyngitis, the primary raw material according to weight portion is：15 parts of Tea Polyphenols, paddy
8 parts of propylhomoserin sodium, 14 parts of allicin, 10 parts of amoxycillin, 2 parts of Glucurolactone, 4 parts of Paeoniflorin, 2 parts of hypericin, gold and silver
5 parts of flower extract.
A kind of preparation method of the pharmaceutical composition for treating chronic pharyngitis, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Tea Polyphenols, sodium glutamate, allicin, amoxycillin green grass or young crops are weighed by above-mentioned metering ratio
Mycin, Glucurolactone, Paeoniflorin, hypericin, Honegsukle flower P.E, sieve, and machinery adds ultra-pure water after mixing, and places pharmacy
In mixer, mix 4min, control RSD≤5%, compressing tablet low temperature drying after mixing, at 4 DEG C, packaging is handy to temperature control
Pharmaceutical composition in treatment chronic pharyngitis.
Embodiment 2
A kind of pharmaceutical composition for treating chronic pharyngitis, the primary raw material according to weight portion is：16 parts of Tea Polyphenols, paddy
10 parts of propylhomoserin sodium, 16 parts of allicin, 11 parts of amoxycillin, 3 parts of Glucurolactone, 5 parts of Paeoniflorin, 2 parts of hypericin, gold and silver
5 parts of flower extract.
A kind of preparation method of the pharmaceutical composition for treating chronic pharyngitis, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Tea Polyphenols, sodium glutamate, allicin, amoxycillin green grass or young crops are weighed by above-mentioned metering ratio
Mycin, Glucurolactone, Paeoniflorin, hypericin, Honegsukle flower P.E, sieve, and machinery adds ultra-pure water after mixing, and places pharmacy
In mixer, mix 4min, control RSD≤5%, compressing tablet low temperature drying after mixing, at 4 DEG C, packaging is handy to temperature control
Pharmaceutical composition in treatment chronic pharyngitis.
Embodiment 3
A kind of pharmaceutical composition for treating chronic pharyngitis, the primary raw material according to weight portion is：17 parts of Tea Polyphenols, paddy
12 parts of propylhomoserin sodium, 18 parts of allicin, 12 parts of amoxycillin, 5 parts of Glucurolactone, 7 parts of Paeoniflorin, 3 parts of hypericin, gold and silver
8 parts of flower extract.
A kind of preparation method of the pharmaceutical composition for treating chronic pharyngitis, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Tea Polyphenols, sodium glutamate, allicin, amoxycillin green grass or young crops are weighed by above-mentioned metering ratio
Mycin, Glucurolactone, Paeoniflorin, hypericin, Honegsukle flower P.E, sieve, and machinery adds ultra-pure water after mixing, and places pharmacy
In mixer, mix 6min, control RSD≤5%, compressing tablet low temperature drying after mixing, at 6 DEG C, packaging is handy to temperature control
Pharmaceutical composition in treatment chronic pharyngitis.
Embodiment 4
A kind of pharmaceutical composition for treating chronic pharyngitis, the primary raw material according to weight portion is：18 parts of Tea Polyphenols, paddy
13 parts of propylhomoserin sodium, 20 parts of allicin, 13 parts of amoxycillin, 7 parts of Glucurolactone, 9 parts of Paeoniflorin, 4 parts of hypericin, gold and silver
10 parts of flower extract.
A kind of preparation method of the pharmaceutical composition for treating chronic pharyngitis, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Tea Polyphenols, sodium glutamate, allicin, amoxycillin green grass or young crops are weighed by above-mentioned metering ratio
Mycin, Glucurolactone, Paeoniflorin, hypericin, Honegsukle flower P.E, sieve, and machinery adds ultra-pure water after mixing, and places pharmacy
In mixer, mix 8min, control RSD≤5%, compressing tablet low temperature drying after mixing, at 8 DEG C, packaging is handy to temperature control
Pharmaceutical composition in treatment chronic pharyngitis.
Embodiment 5
A kind of pharmaceutical composition for treating chronic pharyngitis, the primary raw material according to weight portion is：20 parts of Tea Polyphenols, paddy
14 parts of propylhomoserin sodium, 22 parts of allicin, 15 parts of amoxycillin, 8 parts of Glucurolactone, 10 parts of Paeoniflorin, 4 parts of hypericin, gold
10 parts of honeysuckle flower extract.
A kind of preparation method of the pharmaceutical composition for treating chronic pharyngitis, concretely comprises the following steps：
First, in pharmaceutical grade clean area, Tea Polyphenols, sodium glutamate, allicin, amoxycillin green grass or young crops are weighed by above-mentioned metering ratio
Mycin, Glucurolactone, Paeoniflorin, hypericin, Honegsukle flower P.E, sieve, and machinery adds ultra-pure water after mixing, and places pharmacy
In mixer, mix 8min, control RSD≤5%, compressing tablet low temperature drying after mixing, at 8 DEG C, packaging is handy to temperature control
Pharmaceutical composition in treatment chronic pharyngitis.
The medicine of embodiment of the present invention 1-5 preparation, through acute and chronic toxicology test, all no finds toxic reaction.
Using method：
Twice daily, each 1g, 5 days is a course for the treatment of.
Model case：
Zhao, man, 24 years old, every morning dry persistent coughs, when weather turns cold, throat is itched, and dry swells and ache, diagnosis：Chronic
Pharyngitis.Using the medicine of the embodiment of the present invention 3 preparation, after taking two courses for the treatment of, symptom all disappears.
Lee, female, 37 years old, abscess of throat after speaking for a long time, swallow pain, and with nausea, diagnose：Chronic pharyngitis.
Using the medicine of the embodiment of the present invention 3 preparation, after taking three courses for the treatment of, symptom all disappears.
Money, female, 53 years old, pharyngeal itch pain, burning sensation, and occur having a headache, weak, diagnosis：Acpuei pharyngitis.Using this use
The medicine of the embodiment of the present invention 3 preparation, after taking four courses for the treatment of, symptom all disappears.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of the spirit or essential attributes of the present invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment only wraps
Containing an independent technical scheme, only for clarity, those skilled in the art should for this narrating mode of specification
Using specification as an entirety, the technical scheme in each embodiment can also form those skilled in the art through appropriately combined
Understandable other embodiment.
Claims (6)
1. a kind of pharmaceutical composition for treating chronic pharyngitis is it is characterised in that the primary raw material according to weight portion is：Tea is many
Phenol 15-20 part, sodium glutamate 8-14 part, allicin 14-22 part, amoxycillin 10-15 part, Glucurolactone 2-8 part, Chinese herbaceous peony
Glycosides 4-10 part, hypericin 2-4 part, Honegsukle flower P.E 5-10 part.
2. the pharmaceutical composition for treating chronic pharyngitis according to claim 1 it is characterised in that described for treating
The pharmaceutical composition of chronic pharyngitis, the primary raw material according to weight portion is：Tea Polyphenols 16-18 part, sodium glutamate 10-13 part, big
Allicin 16-20 part, amoxycillin 11-13 part, Glucurolactone 3-7 part, Paeoniflorin 5-9 part, hypericin 2-4 part, gold and silver
Flower extract 5-10 part.
3. the pharmaceutical composition for treating chronic pharyngitis according to claim 1 and 2 is it is characterised in that described be used for
Treat the pharmaceutical composition of chronic pharyngitis, the primary raw material according to weight portion is：17 parts of Tea Polyphenols, 12 parts of sodium glutamate, garlic
18 parts of element, 12 parts of amoxycillin, 5 parts of Glucurolactone, 7 parts of Paeoniflorin, 3 parts of hypericin, 8 parts of Honegsukle flower P.E.
4. a kind of preparation method of the described pharmaceutical composition for treating chronic pharyngitis as arbitrary in claim 1-3, it is special
Levy and be, concretely comprise the following steps：
First, in pharmaceutical grade clean area, Tea Polyphenols, sodium glutamate, allicin, Amoxcillin are weighed by above-mentioned metering ratio
Element, Glucurolactone, Paeoniflorin, hypericin, Honegsukle flower P.E, sieve, and machinery adds ultra-pure water after mixing, and place pharmacy and mix
In conjunction machine, mix 4-8min, control RSD≤5%, compressing tablet low temperature drying after mixing, at 4-8 DEG C, packaging obtains final product temperature control
For treating the pharmaceutical composition of chronic pharyngitis.
5. the preparation method of the pharmaceutical composition for treating chronic pharyngitis according to claim 4 is it is characterised in that have
6min is mixed in body step.
6. the preparation method of the pharmaceutical composition for treating chronic pharyngitis according to claim 4 is it is characterised in that have
In body step, temperature control is at 6 DEG C.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860754A (en) * | 2017-02-23 | 2017-06-20 | 谢松甫 | A kind of pharmaceutical composition for treating chronic pharyngitis |
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| CN1313084A (en) * | 2000-03-09 | 2001-09-19 | 陈建操 | Application of tea polyphenol in medicine to treat diseases in respiratory system |
| CN103610659A (en) * | 2013-12-06 | 2014-03-05 | 湖南中南大学湘雅口腔医院 | Allicin medicinal composition and preparation method thereof |
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| CN106860754A (en) * | 2017-02-23 | 2017-06-20 | 谢松甫 | A kind of pharmaceutical composition for treating chronic pharyngitis |
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Application publication date: 20170208 |