CN106360745A - Enhancing composition for dietary fiber type product and application of enhancing composition - Google Patents
Enhancing composition for dietary fiber type product and application of enhancing composition Download PDFInfo
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- CN106360745A CN106360745A CN201610750703.5A CN201610750703A CN106360745A CN 106360745 A CN106360745 A CN 106360745A CN 201610750703 A CN201610750703 A CN 201610750703A CN 106360745 A CN106360745 A CN 106360745A
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- dietary fiber
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- 229930193551 sterin Natural products 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 229940098466 sublingual tablet Drugs 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an enhancing composition for a dietary fiber type product and application of the enhancing composition. Effective components of the enhancing composition for the dietary fiber type product comprise dietary fibers and an enhancer. After the enhancing composition for the dietary fiber type product disclosed by the invention is used, the health-care treatment effects of the dietary fibers are enhanced; and the composition disclosed by the invention can be applied to functional health-care foods, and is used for generally promoting health or is used as a medical composition component to be applied to drugs for treating intestinal system diseases, cardiovascular diseases, diabetes, inflammation, cancer, central nerve system diseases and autoimmunity diseases.
Description
Technical field
The invention belongs to functional health care food field, it is more particularly related to a kind of dietary fiber class product increases
Strong compositionss and its application.
Background technology
The definition of dietary fiber is the edible food composition do not digested and assimilated by digestion, many including non-starch
Sugar, lignin, and indigestible oligosaccharide and resistant starch.Dietary fiber and the functional health product with dietary fiber preparation
A well-known effect be to prevent or treat constipation and diarrhoea.But existing dietary fiber function more single it is impossible to
Auxiliary is improved, is prevented and treated more human body diseases.
Content of the invention
It is an object of the invention to, provide a kind of assist improvement, prevent and treat more human body diseases dietary fiber
Class product enhancing composition and its application.
In order to realize foregoing invention purpose, the present invention provides a kind of dietary fiber class product enhancing composition, said composition
Effective ingredient include dietary fiber and reinforcing agent, by weight percentage, dietary fiber: reinforcing agent=99.9%:0.1%-
70%:30%.
As one kind improvement of dietary fiber class product enhancing composition of the present invention, described dietary fiber includes semen pulicariae
Shell, lantago Psyllium powder or Caulis Sacchari sinensis fiber powder.
As one kind improvement of dietary fiber class product enhancing composition of the present invention, described reinforcing agent includes Moringa tree and produces
Product, Monas cuspurpureus Went rice product, the mixing of one or two or more kinds of grape product, raw material of Chinese medicine medicine or flavoring agent.
As one kind improvement of dietary fiber class product enhancing composition of the present invention, described Moringa tree product is Moringa
Seed, moringa seeds powder, Moringa seed extract, leaf of Moringa, leaf of Moringa powder, Moringa bar powder or moringa root powder.
As one kind improvement of dietary fiber class product enhancing composition of the present invention, described Monas cuspurpureus Went rice product is Monas cuspurpureus Went
Powder or Monas cuspurpureus Went rice extracts.
As one kind improvement of dietary fiber class product enhancing composition of the present invention, described grape product includes Semen Vitis viniferae
Powder, grape skin powder or grape extract.
As one kind improvement of dietary fiber class product enhancing composition of the present invention, described raw material of Chinese medicine medicine includes pellet
Ginseng, Semen Ginkgo, Radix Notoginseng, Fructus Lycii, Herba Ephedrae, Radix Ginseng or Radix Puerariae.
As one kind improvement of dietary fiber class product enhancing composition of the present invention, described flavoring agent includes Fructus Citri junoriss, Fructus Citri tangerinae
Son, Fructus Citri Limoniae, Herba Menthae, Flos Rosae Rugosae, jasmine, Rhizoma et radix valerianae or their extract.
In order to realize foregoing invention purpose, present invention also offers a kind of dietary fiber class product enhancing composition preparation,
Above-mentioned dietary fiber class product enhancing composition is prepared into peroral dosage form.
As one kind improvement of dietary fiber class product enhancing composition preparation of the present invention, 0.2 gram -2 grams upper will be included
State the peroral dosage form that compositionss are prepared in capsule shells.
As one kind improvement of dietary fiber class product enhancing composition preparation of the present invention, 0.2 gram -2 grams upper will be included
State the dietary fiber in compositionss and reinforcing agent composition is prepared in different capsule shells respectively, the mouth simultaneously or asynchronously taken
Oral dosage form.
As one kind improvement of dietary fiber class product enhancing composition preparation of the present invention, 1.0 grams -20 grams upper will be included
State compositionss to be prepared in a packaging bag, the peroral dosage form that can partly or entirely take.
As one kind improvement of dietary fiber class product enhancing composition preparation of the present invention, 1.0 grams -20 grams upper will be included
State the dietary fiber in compositionss and reinforcing agent composition is prepared in different packaging bags respectively, can partly or entirely simultaneously or not
The peroral dosage form simultaneously taken.
As one kind improvement of dietary fiber class product enhancing composition preparation of the present invention, 20 grams -2000 grams will be included
Above-mentioned composition is prepared into the peroral dosage form that can partly take in a packing box or Packaging Bottle.
As one kind improvement of dietary fiber class product enhancing composition preparation of the present invention, 20 grams -2000 grams will be included
Dietary fiber in above-mentioned composition and reinforcing agent composition are prepared in different packing boxes or Packaging Bottle respectively, can part same
When or the peroral dosage form asynchronously taken.
Present invention also offers dietary fiber class product enhancing composition is in preparation prevention and/or treatment intestinal tract disease
Application in disease, cardiovascular disease, diabetes, inflammation, the medicine of cancer, central nervous system disease and autoimmune disease.
Using the dietary fiber class product enhancing composition of the present invention, enhance the health protection and therapeutic action of dietary fiber, this
The compositionss of invention can apply to functional health-care food, exists for universal promotion health or as pharmaceutical composition composition
Application in therapy-related disease.
Specific embodiment
Below by way of specific instantiation, embodiments of the present invention are described, those skilled in the art can be by this specification
Disclosed content understands other advantages and effect of the present invention easily.The present invention can also be by addition different concrete realities
The mode of applying is carried out or applies, and the every details in this specification can also be based on different viewpoints and application, without departing from
Carry out various modifications and changes under the spirit of the present invention.
In order to prepare more extensive sanatory utilitarian function food (health product) dosage form, the present invention provides a kind of meals fine
Dimension class product enhancing composition.The principle active component of formula includes dietary fiber and reinforcing agent, and wherein dietary fiber includes ocean
Semen Plantaginiss etc., it is (moringa seeds, moringa seeds powder, Moringa seed extract, leaf of Moringa, leaf of Moringa powder, peppery that reinforcing agent includes Moringa tree product
Rod powder or moringa root powder).Said composition also may include Chinese medicine ingredients such as Monas cuspurpureus Went etc..This compositions constitutes new dosage form, increases
The strong health protection and therapeutic action of dietary fiber.The compositionss of the present invention can apply to functional health-care food, for universal
Promote health or the application in therapy-related disease as pharmaceutical composition composition.
Moringa tree (moringa oleifera), also known as drumstick tree, Wasabia japonic (Euterma Wasabi) tree, belongs to Moringa tree section.Moringa tree is in recent years
Take a kind of emerging health food.Moringa contains functional living being alkali, high calcium, high protein, high microsteping；Have physical strength reinforcing,
The effects such as treatment anemia, suppression pathogenic bacteria, expeling parasite, there is extensive health therapy function to health.
Think that Moringa tree can medically be applied to glycosuria with prevention of various diseases according to Hindu medicine checking in 1,100
The diseases such as disease, hypertension, dermatosiss, anemia, skeleton, anti-melancholy, arthritis, digestive organs, tumor.
Preparatory department of TaiWan, China Moringa tree EASD is within six months through the checking that uses of 500 people, discovery half
Above user has good improvement, include eczema, rich and honour handss, tinea pediss, scorching property headache, osteoporosis,
Diabetes, neurasthenia, rheumatic arthritis, anemia, gout, insomnia, skin is baffled to itch, melancholia, stable nerve, dysmenorrhoea, just
Secret, dyspepsia, spot fading, have a delicate constitution, refresh oneself, sexual function improving etc..
Leaf of Moringa powder on market, moringa seeds, Moringa powder of seeds, Moringa seed extract etc. all can be eaten as functional health
Product, provide the health care and disease prevention function of Moringa.The composite dosage form of the present invention includes such Moringa tree product.
Monas cuspurpureus Went is found in China earliest, the production of existing more than 1,000 year, applicating history, is China and surrounding countries are distinctive
Rice fermentation traditional product.Monas cuspurpureus Went ancient times claim red song, are Chinese medicine, are food again, are to be inoculated in rice with Monascus fungus
Upper fermented it is prepared from.As Chinese medicine, there is the effects such as blood circulation promoting and blood stasis dispelling, strengthening the spleen to promote digestion.
Modern biotechnology scholar comforms and filters out Monascus anka Nakazawa et sato in many Monas cuspurpureus Went strain, is found that and can reduce blood in its metabolite
The natural statin substance of clearing gallbladder sterin.Have passed through substantial amounts of work wild-type strain makes a variation as producing strain, make it to produce
High-load, stable, human body synthetic cholesterol key enzyme (hmg-coa reductase) specific inhibitor-natural that is being suitable for pharmacy
Statin substance, can also produce many compositions beneficial to human body, such as essential amino acids, unsaturated fatty acid etc. simultaneously.This
Class purpose-made monascus have been used to pharmacy now, numerous studies find it have very powerful reduction T-CHOL, reduce low close
Degree lipoprotein cholesterol, reduce serum triglycerides, reduce atherogenic index, high density lipoprotein increasing cholesterol
Notable comprehensive therapeutic effect and take safe, Small side effects, and can effectively treat the cardiovascular and cerebrovascular diseases such as coronary heart disease, apoplexy
And the disease related to hyperlipidemia, such as diabetes, the nephrotic syndrome and fatty liver.
Present invention incorporates dietary fiber, Moringa tree product, the effect beneficial to human body such as Monas cuspurpureus Went, these are effectively become
Divide and be prepared into different composite dosage form, to promote human health.Or it is prepared into compound health products or pharmaceutical dosage form to treat not
Same disease, including but not limited to intestinal tract disease, cardiovascular system diseases, the disease of cancer and correlation.
In one embodiment, the present invention provides dietary fiber and reinforcing agent synthetic to alleviate or to treat constipation and abdomen
Rush down.This synthetic includes semen pulicariae and Moringa tree product.Semen pulicariae is in low dosage (each taking 0.5-1.5g) Shi Kehuan
Solution or treatment habitual diarrhea, can alleviate when high dose (each taking 4-6g) or treat habitual constipation.Moringa tree product
The therapeutical effect improving semen pulicariae can be worked in coordination with.
In another embodiment, the present invention provides dietary fiber and reinforcing agent synthetic to alleviate or to treat cardiovascular system
System disease, including hypertension, hyperlipidemia, heart disease, apoplexy etc..This synthetic includes semen pulicariae and Monas cuspurpureus Went.Semen pulicariae can
The effect of the collaborative reduction cholesterol strengthening Monas cuspurpureus Went.The semen pulicariae of various dose and Monas cuspurpureus Went can be used for preventing and treating the different degrees of heart
Vascular system disease.
Further, in another embodiment, the present invention provides dietary fiber and reinforcing agent synthetic wider to prevent and treat
General disease, or wider enhancing health.Such disease includes cardiovascular system diseases, metabolic disease, diabetes, nervous system
Preventing and treating of disease, autoimmune pathologies, cancer, and some antibacterials and virus infection etc..This synthetic includes semen pulicariae,
Moringa tree product, and Monas cuspurpureus Went.The semen pulicariae of various dose, Moringa tree product, and Monas cuspurpureus Went can be used for preventing and treating different diseases
Disease.These compositions can work in coordination with enhancing each treatment to healthy promotion with to disease.
In various embodiments, one of active component comprises dietary fiber.In another embodiment, dietary fiber is
Semen pulicariae fiber.In a related embodiment, semen pulicariae comprises the rickshaw of about 80-99% purity (rubber cement agent content)
Front sub- shell.In another related embodiment, semen pulicariae comprises the semen pulicariae of about 80-99% purity (rubber cement agent content)
Shell powder.
In various embodiments, in oral dosage, lantago Psyllium fiber content is usually variable, adjusts model
Enclosing can be from about 0.5 gram to about 10 grams, from about 0.75 gram to about 7.5 grams, from about 1.25 grams to about 5 grams, from about 2 grams to about 4
Gram, about 1 gram, about 2 grams, about 3 grams, about 4 grams, about 5 grams, about 6 grams, about 7 grams, about 8 grams.
In various embodiments, one of active component comprises Moringa tree product.In a related example, Moringa tree
Product includes moringa seeds, Moringa powder of seeds and Moringa seed extract.In another related example, Moringa tree product includes peppery
Wooden leaf, leaf of Moringa powder and moringa oleifera leaf extractive.Further in another related example, Moringa tree product includes Moringa bar
Portion and Moringa root, Moringa bar portion and Moringa root powder, and Moringa bar portion and Moringa root extract.
In various embodiments, in oral dosage, the content of Moringa tree product is usually variable, range of accommodation
Can be from about 10 milligrams to about 500 milligrams, from about 50 milligrams to about 400 milligrams, from about 100 milligrams to about 350 milligrams, from about
200 milligrams to about 300 milligrams, about 20 milligrams, about 50 milligrams, about 75 milligrams, about 100 milligrams, about 150 milligrams, about 200 milligrams,
About 300 milligrams, about 400 milligrams.
In various embodiments, one of active component comprises Monas cuspurpureus Went.In a related example, Monas cuspurpureus Went includes
Monas cuspurpureus Went powder-product containing the natural statin of 0.1-5%.In another related example, Monas cuspurpureus Went was included containing 0.1-5% days
So Monas cuspurpureus Went extract product of statin.
In various embodiments, in oral dosage, the content of Monas cuspurpureus Went is usually variable, and range of accommodation is permissible
It is from about 50 milligrams to about 1000 milligrams, from about 75 milligrams to about 750 milligrams, from about 125 milligrams to about 500 milligrams, from about 200
Milligram arrives about 400 milligrams, about 100 milligrams, about 200 milligrams, about 300 milligrams, about 400 milligrams, about 500 milligrams, about 600 milligrams,
About 700 milligrams, about 800 milligrams.
In another related example, present invention offer semen pulicariae, Moringa tree product, Monas cuspurpureus Went product active ingredient
Different proportion enhancing composition combination, be prepared into different dosage forms.
In another related example, for strengthening health protection and therapeutic action, the enhancing composition that the present invention provides includes to be controlled
The natural plants for the treatment of effect or Chinese medicinal powder or extract, such as in grape pip powder, grape skin powder, grape extract and tradition
Medical Radix Salviae Miltiorrhizae, Semen Ginkgo, Radix Notoginseng, Fructus Lycii, Herba Ephedrae, Radix Ginseng, Radix Puerariae etc..
In another related example, for adjusting mouthfeel and having additional nutrients, the enhancing composition that the present invention provides includes
Natural adjustment taste and the plant having additional nutrients, such as Fructus Citri junoriss, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Flos Rosae Rugosae, jasmine, Rhizoma et radix valerianae or they
Extract.
The dietary fiber enhancing composition dosage form that the present invention provides can be acceptable oral with any health product and medicine
Dosage form is supplied to application person.Preferably dosage form is to be prepared into pill, tablet, or the peroral dosage form of the form such as capsule.But
As long as active component can be fully absorbed and utilize, any other form of medication can be applied, such as powder or liquid
Mixture.The present invention also provides health product and pharmaceutical composition, the health product including unit dosage form and pharmaceutical dosage form.Here
Plant in dosage form, dosage form following can be divided into appropriately sized unit dose.This dosage contain reach enough health care or treatment mesh
The dietary fiber of target appropriate amount strengthens dosage form active component.
The present invention provides capsule, tablet, liquid, syrup state, suspension liquid, Sublingual tablet, confection type accordingly, and chewable tablet shape
The dietary fiber of formula strengthens dosage form.
The present invention also includes strengthening the health product of dosage form and the preparation method of pharmaceutical composition.
Health product and pharmaceutical dosage form can include drug excipient.Excipient must be to be suitable for patient's application, conventional
Low toxicity and highly purified.
Drug excipient selects according to application form, such as oral tablet, capsule, powder-type, syrup type, floating type etc..
Drug excipient should be consistent with traditional process for preparing medicine, and be the industry technical field known to.Such as dietary fiber
The oral capsule strengthening dosage form can include preservative, flavoring agent, and coloring agent etc..
The present invention includes the solid dosage formss as tablet and capsule.The preparation method of capsule is by dietary fiber as above
In enhancing composition implant capsule shell when producing.Dietary fiber enhancing composition is to be filled in hard capsule in certain embodiments
Or in soft capsule.Capsule shells can use methylcellulose, hydroxypropylmethyl cellulose,
Polyvinyl alcohols, or denatured gelatins gelatin or starch or other materials preparation.Hard-shell capsule is general
It is to be prepared with the bone of high glue intensity and the mixture of pigskin gelatin, can also be with the preparation of pure plant raw material.In some embodiments
Middle unit dosage form is a gel capsule.Capsule shells are glycerol capsule shells in certain embodiments.Real at other
Applying capsule shells in example is a Bos taurus domesticus Gmelin shell.The raw material that other are suitable for doing capsule shells includes polyethylene,
polypropylene,poly(methylmethacrylate),polyvinylchloride,polystyrene,
polyurethanes,polytetrafluoroethylene,nylons,polyf ormaldehydes,polyesters,
Ellulose acetate, and nitrocellulose.Capsule shells itself can the pigment containing a small amount of, opacifying agent, plasticising
Agent, and preservative.Prepare other Solid Dosage Forms traditional method such as prepare suppository etc. also it is known that.Gelatine capsule shell is also
Tapioca starch can be used, grass, vegetable source and the preparation of Fish source gelatin.
In other examples, capsule shells comprise speed limit membrane material, and including coating, filling dietary fiber in the inside strengthens lives
Property composition.Capsule shells can use porous or ph- sensitization polymer, with the method preparation of heat forming technology.In some realities
Applying capsule shells in example is an anisotropic membrane, is the film that there is thin skin on a surface, but the thickness of most of film is can by height
The material of infiltration is constituted.The active component of dietary fiber enhancing composition is to be filled in enteric coating preparation in certain embodiments
Soft capsule in.Enteric coated capsule can with those skilled in the art all known to standard method preparation.
The active component of dietary fiber enhancing composition is to be filled in slow release or/and release for a long time in certain embodiments
In the capsule put, to ensure the release of in good time He stable active component.In those skilled in the art, various different
The technology of preparing of slow release or/and sustained release formulation type is well-known.
Conventional method for preparing tablet thereof is well-known in the art.The method includes seasoning, such as directly compresses and presses
Contracting granule, or wet method or other special methods.
Liquid dosage form includes being prepared into solution, suspension and emulsion.The illustration of liquid drug formulation, including propyleneglycoles
Solution and be prepared into the oral liquid containing sweeting agent, suspension and emulsion.
Dietary fiber class product enhancing composition can comprise a kind of plasticizer, particularly in capsule shells.Suitable increasing
Mould agent to include as macrogol (peg) class such as peg 300, peg 400, peg 600, peg 1450, peg 3350, and peg
800, stearic acid, macrogol, Oleic acid, triethyl group cellulose, and glyceryl triacetate.
Described dietary fiber enhancing composition dosage form can be with coating.Described coating can use enteric coating, i.e. coating used
Mainly in enteral dissolving, but substantially soluble in gastric juice.The illustration of enteric coating includes polyvinyl acetate
phthalate(pvap).In addition, what follows enteric polymer can be applied: colorcon.rtm.,
hydroxypropylmethylcellulose acetate succinate(hpmcas),cellulose acetate
phthalate(cap),methacrylic acid copolymer,hydroxypropylmethylcellulose
succinate,cellulose acetate succinate,cellulose acetate hexahydrophthalate,
hydroxypropylmethylcellulose hexahydrophthalate,
hydroxypropylmethylcellulosephthalate(hpmcp),cellulose propionate phthalate,
cellulose acetate maleate,cellulose acetate trimellitate,cellulose acetate
butyrate,cellulose acetate propionate,methacrylic acid/methacrylate polymer,
methacrylic acid-methyl methacrylate copolymer,ethyl methacrylate-
Methylmethacrylate-chlorotrimethylammonium ethyl methacrylate copolymer, and phase
As, and the polymeric combination of one or more enteric as described above.Other illustrations include nature resin, such as shellac,
Sandarac, copal collophorium, and as above polymeric combination described in one or more.Other enterics gather further
Fit illustration includes hydroxyl synthetic resin.
Described dietary fiber class product enhancing composition, can include a kind of stabilizer." stabilizer " is included in a timing
Between can keep the compound of desired dosage form attribute, this attribute including but not limited to can be in laboratory inspection to machinery
, chemistry, and the resistance of the infringement of temperature.This attribute includes, to concentration, the effect of institute's labelling, keeping the purity specified, and
The static stabilization of in the gastrointestinal dispersibility and no homogenizing of obvious degradation in the presence of stabilizer.In some enforcements
Described in example, stabilizer is antioxidant, such as vitamin e.Other suitable antioxidants include benzyl alcohol, butyrate, benzoquinone,
And ascorbic acid (vitamin c).
Described dietary fiber class product enhancing composition, can include a kind of preservative.Preservative is suppression microorganism life
Long compound, and be normally incorporated in pharmaceutical dosage form and prevent growth of microorganism.The amount of typical preservative can be according to usp and eu
Method test simultaneously determines.Preservative including but not limited to sorbic acid first, methyl parahydroxybenzoate, propyl p-hydroxybenzoate,
Benzoic acid and its salt, other p-hydroxybenzoic acid fat such as butyl p-hydroxybenzoates, alcohol type such as ethanol and benzene alcohol, phenol
Compound such as phenol, or level Four compound such as benzalkonium chloride.
Coloring agent provides compositionss or dosage form color.This kind of excipient can include food grade pigment and food grade pigment is inhaled
Receive on a kind of suitable adsorbent such as clay or aluminium oxide.The consumption of coloring agent can be adjusted, such as from about 0.1% to about 5%
Compositionss of weight or from about 0.1% to about 1%.
The present invention provides and includes applying dietary fiber enhancing composition as the side of health care product and disease preventing and treating
Method.
The present invention provides the patient to needing for the dietary fiber enhancing composition, is prevented and treated, including but not limited to following disease
Disease: gastrointestinal system disease includes constipation and diarrhoea, the related disease of cardiovascular system, autoimmune disease, inflammation correlation disease
Disease, central nervous system disease, and cancer etc..Non-human patients include domestic animal, such as cattle, sheep, and horse and house pet, such as cat and
Canis familiaris L..
Method with the treatment of meals fiber enhancer type described herein includes using meals fiber reinforcement to required patient
Dosage form prevention disease, such as prevents cardiotomy infectious-related complication, and treats such sequela.This invention is included in cardiac muscle stalk for the first time
After death it is supplied to patient at least 60 days, 180 days, 360 days, or at least described once a day dietary fiber enhancing in unlimited sky
Dosage form, the method being prevented with reaching or reducing secondary myocardial infarction.
In one embodiment, the present invention provides a method strengthening health with health care product.The method bag
Include and give compositionss or the synthesis dosage form that one present invention of demand object provides.
In another embodiment, the method that the present invention provides a treatment constipation and diarrhoea.The method includes giving to be needed
Compositionss or the synthesis dosage form of one present invention offer of object are provided.In one embodiment, this disease is common in old people
Habitual constipation, in combination dosage forms the consumption of semen pulicariae be 4-8 gram/times, daily 1-3 time.In another embodiment, this
Disease is habitual diarrhea, and in combination dosage forms, the consumption of semen pulicariae is 0.5-2.0 gram/times, daily 1-3 time.
In another embodiment, the method that the present invention provides a treatment cardiovascular system and relevant disease.The method
Including the compositionss giving one present invention offer of demand object or synthesis dosage form.In one embodiment, this cardiovascular system
Disease is arteriosclerosis.
In another embodiment, the present invention provides one kind to required patient treatment or to prevent primary hypercholesterolemia
And/or the method for mixing dyslipidemia, the method includes giving one or more the compositions disclosed herein of required patient.
In another embodiment, present invention offer is a kind of treats to the patient having disease history or prevents the nonfatal heart
The method of flesh infarction risk of relapse, the method includes giving one or more the compositions disclosed herein of required patient.
In another embodiment, the present invention provides one kind to required patient treatment or to prevent, and lowers progression of disease speed
Degree or promote to recover atheromatous method, the method includes giving required patient that one or more are disclosed herein
Compositionss.
In another embodiment, the present invention provides a kind of method suppressing lipoprotein oxidation to required patient, the method
Including giving one or more the compositions disclosed herein of required patient.
In another embodiment, the present invention provides a kind of method removing free radical to required patient, and the method includes
Give one or more the compositions disclosed herein of required patient.
In another embodiment, the present invention provides a kind for the treatment of of the patient to needs or prevents superelevation serum triglycerides
The method of (i.e. type iv and v hyperlipidemia), the method includes giving one or more the compositions disclosed herein of required patient.
It will be appreciated that the dosage level needed for a patient is different.Special dosage is according to different situations not
With including the activity of compound used therefor, the age of patient, body weight, health status, sex, administration time, route of administration, exclusion
Speed, combination with medication, and order of severity of treated disease etc..
In one embodiment, compositionss described herein can be administered for once or twice daily or three times.?
In another embodiment, 1,2,3,4,5,6,7,8 capsules of patient can be given daily, each capsule is containing the present invention's
The dietary fiber of specific combination strengthens the active component of dosage form.In another embodiment, can give every morning patient 1 or
2 or multiple capsules, such as from about early 5 points are arrived at about early 11 points, then can give patient 1 or 2 or multiple capsules every night again, such as from about
In 5 points to about late 11 points of evening, the dietary fiber that each capsule contains specific combination described herein strengthens the activity of dosage form
Component.
In another embodiment, 1,2,3,4,5,6,7,8 capsules of patient can be given daily, each capsule divides
The dietary fiber of the not specific combination containing the present invention strengthens the single-activity component in dosage form.In another embodiment, institute
State single-activity Ingredients Capsule can take simultaneously or asynchronously.In another embodiment, patient 1 can be given every morning
Or 2 or multiple described single capsule, such as from about early 5 points are arrived at about early 11 points, then can give patient 1 or 2 or many every night again
Individual capsule, such as from about late 5 points Dao about late 11 points, these Capsules group collectively form the required active one-tenth of institute strengthening dosage form of patient
Point.
In another embodiment, method available dietary fiber enhancing composition is oral administered dosage form accordingly.Noun
" oral administration " or " peroral dosage form " here includes a kind of form of medication to any type of ingredient or compositionss, specifically
Be in the oral cavity that ingredient or compositionss are put into patient after or swallow or do not swallow.So " oral administration " includes mouth
Chamber and Sublingual and esophagus form of medication.In one embodiment, this compositions is in a capsule, and for example plant coagulates
Glue hard capsule.
The compositionss of the present invention can be pressed one or more unit dosage unit formula.Noun " unit dose " herein
Or " unit dosage forms " refer to a part for health product or medical composition, this compositions contain a certain amount of be applied to once to
The medicable dietary fiber of medicine strengthens dosage form.This unit dose can with one or more times daily (i.e. 1 to about 10,1 to about 8,
1 to about 6,1 to about 4,1 to about 2), or any cause medicine reaction and medicable number of times administration.
Embodiment 1 semen pulicariae strengthens preparation
This embodiment is an enhancing dosage form capsule comprising dietary fiber semen pulicariae powder and leaf of Moringa powder.Table 1 arranges
The dosage form going out is that 600 milligrams of capsules comprise dietary fiber (with lantago Psyllium as illustration) and leaf of Moringa powder.Basic preparation
Method is that those skilled in the art are well known and have been described above.Drunk with 100-200 milliliter boiled water or juice when each taking
Material takes.
Table 1: dietary fiber (lantago Psyllium) and leaf of Moringa powder combination dosage forms
Embodiment 2 semen pulicariae strengthens preparation
This embodiment is one and comprises dietary fiber lantago Psyllium powder and Moringa seed extract (moringa seeds
Extract enhancing dosage form capsule).The dosage form that table 2 is listed is that 600 milligrams of capsules comprise dietary fiber (with semen pulicariae
Shell is illustration) and Moringa seed extract.Basic preparation method is that those skilled in the art are well known and have been described above.Each take
When taken with 100-200 milliliter boiled water or juice beverage.
Table 2: dietary fiber (lantago Psyllium) and Moringa seed extract (moringa seeds extract) combination dosage forms
Embodiment 3 semen pulicariae strengthens preparation
This embodiment is one and comprises dietary fiber lantago Psyllium powder and the enhancing dosage form of leaf of Moringa powder is packed.Table 3
The dosage form listed is one 5050 milligrams and packed comprises dietary fiber (with lantago Psyllium as illustration) and leaf of Moringa powder.Basic system
Preparation Method is that those skilled in the art are well known and have been described above.With 300-400 milliliter boiled water or juice when each taking
Beverage is taken after mixing it with water.
Table 3: dietary fiber (lantago Psyllium) and leaf of Moringa powder combination dosage forms
Embodiment 4 semen pulicariae strengthens preparation
This embodiment is one and comprises dietary fiber lantago Psyllium powder and the enhancing dosage form of Moringa seed extract is packed.Table
4 dosage forms listed are one 5050 milligrams and packed comprise dietary fiber (with lantago Psyllium as illustration) and Moringa seed extract.
Basic preparation method is that those skilled in the art are well known and have been described above.When each taking with 300-400 milliliter boiled water or
Juice beverage is taken after mixing it with water.
Table 4: dietary fiber (lantago Psyllium) and moringa seeds extract combination dosage form
Embodiment 5 semen pulicariae strengthens preparation
This embodiment is an enhancing dosage form capsule comprising dietary fiber lantago Psyllium powder and Monas cuspurpureus Went.Monas cuspurpureus Went (Monas cuspurpureus Went
Rice flour or Monas cuspurpureus Went rice extracts).The dosage form that table 5 is listed is that 600 milligrams of capsules comprise dietary fiber and (are with lantago Psyllium
Illustration) and Monas cuspurpureus Went.Basic preparation method is that those skilled in the art are well known and have been described above.100-200 is used when each taking
Milliliter boiled water or juice beverage take.
Table 5: dietary fiber (lantago Psyllium) and Monas cuspurpureus Went combination dosage forms
Embodiment 6 semen pulicariae strengthens preparation
This embodiment is one and comprises dietary fiber lantago Psyllium powder, Moringa seed extract and Monas cuspurpureus Went (Monas cuspurpureus Went powder or
Monas cuspurpureus Went rice extracts) enhancing dosage form capsule.The dosage form that table 6 is listed is that 600 milligrams of capsules comprise dietary fiber (with rickshaw
Front sub- shell is illustration), Moringa seed extract and Monas cuspurpureus Went.Basic preparation method is that those skilled in the art are well known and retouched
State.Taken with 100-200 milliliter boiled water or juice beverage when each taking.
Table 6: dietary fiber (lantago Psyllium), Monas cuspurpureus Went and moringa seeds extract combination dosage form
Embodiment 7 interventional therapy
Mr. first is the man of 60 years old, has chronic diarrhea and the symptom of tongue fur plumpness.Dosage form in oral embodiment 2
Afterwards, diarrhoea and tongue fur problem are corrected.Lantago Psyllium diet fiber product is generally used for treating constipation, but the bright use of this illustration
Dosage described in embodiment 2, lantago Psyllium and Moringa seed extract composite dosage form can treat diarrhoea, and correct other health and ask
Topic.
Embodiment 8 interventional therapy
Mr. second is the man of 65 years old, has long-term chronic constipation, unobstructed a few talent's defecations are once.In oral embodiment
After 3 dosage form, constipation problem is corrected, daily free movement of the bowels.
The announcement of book and teaching according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula carries out suitable change and modification.Therefore, the invention is not limited in specific embodiment disclosed and described above, to this
In the scope of the claims that some modifications and changes of invention should also be as fall into the present invention.Although additionally, this specification
In employ some specific terms, but these terms are merely for convenience of description, do not constitute any restriction to the present invention.
Claims (10)
1. a kind of dietary fiber class product enhancing composition it is characterised in that: effective ingredient includes dietary fiber and reinforcing agent, presses
Percentage by weight, dietary fiber: reinforcing agent=99.9%:0.1%-70%:30%.
2. as claimed in claim 1 a kind of dietary fiber class product enhancing composition it is characterised in that: described dietary fiber
Including lantago Psyllium, lantago Psyllium powder or Caulis Sacchari sinensis fiber powder.
3. as claimed in claim 1 a kind of dietary fiber class product enhancing composition it is characterised in that: described reinforcing agent bag
Include the mixing of one or two or more kinds of Moringa tree product, Monas cuspurpureus Went rice product, grape product, raw material of Chinese medicine medicine or flavoring agent.
4. as claimed in claim 3 a kind of dietary fiber class product enhancing composition it is characterised in that: described Moringa tree produces
Product include moringa seeds, moringa seeds powder, Moringa seed extract, leaf of Moringa, leaf of Moringa powder, Moringa bar powder or moringa root powder；Described
Monas cuspurpureus Went rice product is Monas cuspurpureus Went powder or Monas cuspurpureus Went rice extracts.
5. as claimed in claim 3 a kind of dietary fiber class product enhancing composition it is characterised in that: described grape product
Including grape pip powder, grape skin powder or grape extract；Described raw material of Chinese medicine medicine includes Radix Salviae Miltiorrhizae, Semen Ginkgo, Radix Notoginseng, Fructus Lycii, fiber crops
Huang, Radix Ginseng or Radix Puerariae.
6. as claimed in claim 3 a kind of dietary fiber class product enhancing composition it is characterised in that: described flavoring agent bag
Include Fructus Citri junoriss, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Flos Rosae Rugosae, jasmine, Rhizoma et radix valerianae or their extract.
7. a kind of dietary fiber class product enhancing composition preparation it is characterised in that: by arbitrary for claim 1-6 described meals
Fiber-like product enhancing composition is prepared into peroral dosage form.
8. as claimed in claim 7 a kind of dietary fiber class product enhancing composition preparation it is characterised in that: described oral
Dosage form is that the arbitrary described compositionss of claim 1-6 including 0.2 gram -2 grams are prepared into the oral agents in capsule shells
Type；Or the dietary fiber in the arbitrary described compositionss of claim 1-6 including 0.2 gram -2 grams and reinforcing agent composition are divided
It is not prepared in different capsule shells, the peroral dosage form simultaneously or asynchronously taken.
9. as claimed in claim 7 a kind of dietary fiber class product enhancing composition preparation it is characterised in that: described oral
Dosage form is that the arbitrary described compositionss of claim 1-6 including 1.0 grams -20 grams are prepared in a packaging bag, can part
Or whole peroral dosage forms of taking；Or by the meals in the arbitrary described compositionss of claim 1-6 including 1.0 grams -20 grams
Food fiber and reinforcing agent composition are prepared in different packaging bags respectively, and that can partly or entirely take is oral simultaneously or asynchronously
Dosage form；Or the arbitrary described compositionss of claim 1-6 including 20 grams -2000 grams are prepared into a packing box or packaging
The peroral dosage form that can partly take in bottle；Or 20 grams -2000 grams of the arbitrary described compositionss of claim 1-6 will be included
In dietary fiber and reinforcing agent composition be prepared into respectively in different packing boxes or Packaging Bottle, can part while or different when
The peroral dosage form taken.
10. the arbitrary described dietary fiber class product enhancing composition of claim 1-6 is in preparation prevention and/or treatment intestinal system
Answering in system disease, cardiovascular disease, diabetes, inflammation, the medicine of cancer, central nervous system disease and autoimmune disease
With.
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