CN106356275A - Uniform air supply device for overlaying ring ionic mobility drift tube - Google Patents
Uniform air supply device for overlaying ring ionic mobility drift tube Download PDFInfo
- Publication number
- CN106356275A CN106356275A CN201610641192.3A CN201610641192A CN106356275A CN 106356275 A CN106356275 A CN 106356275A CN 201610641192 A CN201610641192 A CN 201610641192A CN 106356275 A CN106356275 A CN 106356275A
- Authority
- CN
- China
- Prior art keywords
- air
- air supply
- drift
- storing cavity
- pole plate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0422—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for gaseous samples
Abstract
The invention belongs to the technical field of gas supply for overlaying ring ionic mobility, and particularly relates to an air supply device for an overlaying ring ionic mobility drift tube. The air supply device for the overlaying ring ionic mobility drift tube comprises an air inlet, an air storage cavity, air supply openings, a sealing plate and a pole plate connecting opening, wherein the air inlet comprises an air inlet nozzle and an external guide tube; the sealing plate comprises a sealing ring groove and a sealing ring; external supplied air communicates with an internal air storage cavity through the air inlet; except the air supply openings, other positions in the whole air storage cavity are in a sealed state; and all the air supply openings are uniformly distributed between the air storage cavity and an ion drift region to guarantee uniformity of air supply. The air supply device is connected with an overlaying ring pole plate through the pole plate connecting opening which can be adjusted as needed. The whole air supply device can be matched with the structure of the overlaying ring pole plate as needed, the size, the pole plate connecting opening and air supply amount are adjusted, and uniformity of air supply is always ensured.
Description
Technical field
The invention belongs to folding ring ionic mobility to gas technical field and in particular to being a kind of folded ring ionic mobility drift Guan Jun
Spare to device of air.
Background technology
With the development of scientific and technological level, people more thirst for probing into the origin of disease and radical cure mode, protein science, sugared group
The research methoies such as, polypeptide group are following.There is many biomarkers on polysaccharide in human body and glycopeptide component,
The aspects such as the diagnosis of disease, treatment and metabolism play vital effect.Yet with depositing of a large amount of isomerss
So as to isolation technics become one of important difficult point that current biomedicine field exists, this problem also leads to many correlations
The research of disease creates delayed.
Ionic mobility-mass spectrometric hyphenated technique is one of effective means of current separating polyose and glycopeptide, and it is according to same point
The difference of structure between isomer, with buffering gas effect in drift tube, produces different mobilities, thus drift velocity is different, obtains
To separating, recycle mass analyzer detection.But traditional ionic mobility drift tube is to gas mode often in drift pipe end
Punching, buffering gas is injected in drift pipe, although such can fill buffering gas, buffer gas flow by drift pipe to gas mode
Flowing mode is uneven, so that ion is more unordered with the heading of buffering gas collision rift, a large amount of ions cannot be according to both
Determine direction and reach detector, lead to sensitivity to decline serious.
In view of drawbacks described above, the present invention passes through research and innovation, spares to manufacturing and designing a kind of ionic mobility drift Guan Jun
Device of air, can be effectively improved the air-flow uniformity in folded ring ionic mobility drift pipe, reduce ion drift process and rush because of air-flow
The loss of impact, improves sensitivity so as to more the value in industry.
Content of the invention
For solving problem above, the invention provides a kind of uniform and stable folded ring ionic mobility drift pipe is to device of air,
For ionic mobility drift tube to gas, improve it to the separating degree of isomerss sample, sensitivity, reduce noise, improve
Signal to noise ratio, realizes high sensitivity, and the polysaccharide of high accuracy and glycopeptide isomerss separate and analyze.
The uniform and stable folded ring ionic mobility drift pipe that the present invention provides, to device of air, including air inlet, air storing cavity, gives gas
Mouthful, sealing plate, pole plate connector；Wherein:
Described air inlet includes suction nozzle and outer conduit；Gas can effectively temporarily be stored and all by described air storing cavity wherein
Even dispersion；Described is the through hole that several are uniformly distributed between air storing cavity and ion drift area to QI KOU；Described sealing plate
For sealing whole device；Described pole plate connector is connected with folded circumpolar plate for device.
Described air inlet is connected with air storing cavity, and buffering gas is imported in air storing cavity from conduit；Air storing cavity through to QI KOU with
Inner ion drift region is connected, by uniform and stable buffering gas injection drift pipe；Described pole plate connector is not stored up with internal
There is any UNICOM in air cavity or ion drift area.
Preferably, described drift tube can be adjusted according to folded circumpolar chip size to device of air size, and external diameter is 10-200 mm,
Thickness is 5-40 mm；
In the present invention, the outer conduit size of described air inlet is corresponding with suction nozzle size；Suction nozzle size depends on device
Size and required buffer gas flow amount.
Preferably, described suction nozzle internal diameter is 0.5-15 mm；
In the present invention, it is close with device that described sealing plate passes through two two sealing rings being located at the gas storage cavity edge left and right sides respectively
Closing is closed.
Preferably, described air storing cavity volume is 10-3 × 105mm3；
In the present invention, the described quantity to QI KOU is 2-100, is 0.5-30 mm to QI KOU internal diameter.
In the present invention, in whole air storing cavity body in addition to QI KOU, other positions keep air-tight state, all uniform to QI KOU
It is distributed in air storing cavity interval with ion drift, in order to ensure to the uniformity of gas.
In the present invention, described connection plate interface does not have fixed model and structure, depends primarily on different styles and folds circumpolar
The connected mode of plate, corresponding selection interface, thus more perfectly agree with pole plate.
In conventional ion mobility-mass spectrum technology used in conjunction, folded ring ion drift tube to gas mode be only drift pipe end
Top punching, directly to gas, air-flow is uneven and flow direction is relatively chaotic.The present invention utilizes a kind of design of air storing cavity, right
Claim to gas so that air-flow is relatively stable and uniform, be conducive to ion relative to rule and buffering gas collision, and then separate, reduce
Losses of ions, improves detection sensitivity and resolution, has the value in industry.
Brief description
Fig. 1 is folded ring ion drift tube according to embodiments of the present invention to device of air schematic diagram.
Fig. 2 is folded ring ion drift tube according to embodiments of the present invention to device of air sectional drawing.
Specific embodiment
Fig. 1-2 and following explanation are described the embodiment of the present invention in detail and how are instructed those skilled in the art
Realize the reproduction of the present invention.In order to instruct technical scheme, the conventional aspect of some having simplified or having omitted.This area skill
Art personnel should be appreciated that from these embodiments deformation or will within the scope of the invention.Those skilled in the art should manage
Solution following characteristics can combine in every way to form multiple deformation of the present invention.Thus, the invention is not limited in subordinate
Optional embodiment, and only claim and their equivalent limit.
Embodiment:
Fig. 1 representatively illustrates the uniform and stable knot to device of air of folded ring ionic mobility drift pipe described in present example
Structure sketch, as shown in figure 1, described ionic mobility drift pipe includes to device of air:
Air inlet, air storing cavity, to QI KOU, sealing plate, pole plate connector；
Described air inlet includes suction nozzle and outer conduit；Gas can effectively temporarily be stored and all by described air storing cavity wherein
Even dispersion；Described is two full symmetric through holes to QI KOU module；Described sealing plate is used for sealing whole device；Described pole plate
Connector is connected with folded circumpolar plate for device.
Described air inlet is connected with air storing cavity, and buffering gas is imported in air storing cavity through conduit；Air storing cavity through to QI KOU with
Inner ion drift region is connected, by uniform and stable buffering gas injection drift pipe.Described pole plate connector is not stored up with internal
There is any UNICOM in air cavity or ion drift area.
Preferably, described drift tube can be adjusted according to folded circumpolar chip size to device of air size, and external diameter is 10-200 mm,
Thickness is 5-40 mm；
In the present invention, described air inlet outer conduit size is corresponding with suction nozzle size；It is big that suction nozzle size depends on device
Little and required buffer gas flow amount.
Preferably, described suction nozzle internal diameter is 0.5-15 mm；
In the present invention, described sealing plate includes o-ring groove, sealing ring；Sealing plate passes through two and is located at gas storage cavity edge respectively
Two sealing rings of the left and right sides and device seal closure.
Preferably, described air storing cavity volume is 10-3 × 105mm3；
In the present invention, described is the through hole that several are uniformly distributed between air storing cavity and ion drift area to QI KOU.
Preferably, the described quantity to QI KOU is 2-100, is 0.5-30 mm to QI KOU internal diameter.
In the present invention, described connection plate interface does not have fixed model and structure, depends primarily on different styles and folds circumpolar
The connected mode of plate, corresponding selection interface, thus more perfectly agree with pole plate.
To be connected with folded circumpolar plate to device of air using pole plate connector, guarantee whole system using sealing plate module
Closing, it is to avoid gas leakage.Subsequently buffering gas is entered in cushion chamber from outer conduit through air inlet, then through a series of symmetrically and evenly
Arrangement to QI KOU, be flowed into ion drift area, as needed scalable buffer gas flow speed, can optionally adjust to QI KOU simultaneously
Number.
Claims (7)
1. a kind of folded ring ionic mobility drift pipe to device of air it is characterised in that include: include air inlet, air storing cavity, to QI KOU,
Sealing plate, pole plate connector；Wherein:
Described air inlet includes suction nozzle and outer conduit；Gas can effectively temporarily be stored and all by described air storing cavity wherein
Even dispersion；Described is the through hole that several are uniformly distributed between air storing cavity and ion drift area to QI KOU；Described sealing plate
For sealing whole device；Described pole plate connector is connected with folded circumpolar plate for device.
2. described in, air inlet is connected with air storing cavity, and buffering gas is imported in air storing cavity from conduit；Air storing cavity through to QI KOU with interior
Portion ion drift region is connected, by uniform and stable buffering gas injection drift pipe；Described pole plate connector not with internal gas storage
There is any UNICOM in chamber or ion drift area.
3. drift pipe according to claim 1 to device of air it is characterised in that: described drift tube to device of air size according to
Adjust according to folded circumpolar chip size, external diameter is 10-200 mm, thickness is 5-40 mm.
4. drift pipe according to claim 1 to device of air it is characterised in that: the outer conduit size in described air inlet
Corresponding with suction nozzle size；Suction nozzle size depends on device size and required buffer gas flow amount.
5. the drift pipe according to claim 1,2 or 3 to device of air it is characterised in that: described suction nozzle internal diameter be 0.5-
15 mm；
Drift pipe according to claim 4 to device of air it is characterised in that: described air storing cavity volume be 10-3 × 105
mm3.
6. drift pipe according to claim 1 to device of air it is characterised in that: described sealing plate is located at respectively by two
Two sealing rings of the gas storage cavity edge left and right sides and device seal closure.
7. drift pipe according to claim 6 to device of air it is characterised in that: the described quantity to QI KOU be 2-100
Individual, it is 0.5-30 mm to QI KOU internal diameter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610641192.3A CN106356275B (en) | 2016-08-08 | 2016-08-08 | Folded ring ionic mobility drift tube spares to device of air |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610641192.3A CN106356275B (en) | 2016-08-08 | 2016-08-08 | Folded ring ionic mobility drift tube spares to device of air |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106356275A true CN106356275A (en) | 2017-01-25 |
| CN106356275B CN106356275B (en) | 2018-11-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610641192.3A Expired - Fee Related CN106356275B (en) | 2016-08-08 | 2016-08-08 | Folded ring ionic mobility drift tube spares to device of air |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2004464A1 (en) * | 1989-12-01 | 1991-06-01 | R. James Barbour. | Identification of wood species |
| US20030132379A1 (en) * | 2002-01-17 | 2003-07-17 | Gangqiang Li | Ion mobility spectrometer with high ion transmission efficiency |
| CN105185688A (en) * | 2015-08-26 | 2015-12-23 | 中国计量科学研究院 | Mass spectrograph for automatically regulating air pressure inside ion trap and operation method of mass spectrograph |
| CN105702551A (en) * | 2014-12-12 | 2016-06-22 | 安捷伦科技有限公司 | Automatic determination of demultiplexing matrix for ion mobility spectrometry and mass spectrometry |
-
2016
- 2016-08-08 CN CN201610641192.3A patent/CN106356275B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2004464A1 (en) * | 1989-12-01 | 1991-06-01 | R. James Barbour. | Identification of wood species |
| US20030132379A1 (en) * | 2002-01-17 | 2003-07-17 | Gangqiang Li | Ion mobility spectrometer with high ion transmission efficiency |
| CN105702551A (en) * | 2014-12-12 | 2016-06-22 | 安捷伦科技有限公司 | Automatic determination of demultiplexing matrix for ion mobility spectrometry and mass spectrometry |
| CN105185688A (en) * | 2015-08-26 | 2015-12-23 | 中国计量科学研究院 | Mass spectrograph for automatically regulating air pressure inside ion trap and operation method of mass spectrograph |
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| CN106356275B (en) | 2018-11-13 |
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