CN209542533U - Gas-chromatography-ion mobility spectrometry is combined equipment - Google Patents
Gas-chromatography-ion mobility spectrometry is combined equipment Download PDFInfo
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- CN209542533U CN209542533U CN201822122141.7U CN201822122141U CN209542533U CN 209542533 U CN209542533 U CN 209542533U CN 201822122141 U CN201822122141 U CN 201822122141U CN 209542533 U CN209542533 U CN 209542533U
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Abstract
The utility model discloses a kind of gas-chromatography-ion mobility spectrometries to be combined equipment, comprising: gas phase chromatographic device, for carrying out pre-separation to measuring samples to form pre-separation sample；Ion mobility spectrometry apparatus, the communication with gas phase chromatographic device, for being detected to pre-separation sample；With circulation gas path module, it is in fluid communication with the discharge gas interface of ion mobility spectrometry apparatus, for handling the discharge gas being discharged by ion mobility spectrometry apparatus, recycle gas path module also with gas phase chromatographic device gas connection, for part discharge gas to be delivered to gas phase chromatographic device as carrier gas, so that measuring samples enter gas phase chromatographic device under the driving effect of the carrier gas.The gas-chromatography-ion mobility spectrometry combination device miniaturization degree and portability improve.
Description
Technical field
The utility model relates to technical field of analysis and detection, in particular to a kind of gas-chromatography-ion mobility spectrometry combination is set
It is standby.
Background technique
Ionic migration spectrometer (Ion mobility spectrometry, IMS) has portable, quick, sensitive and can industry
The advantages that change, is widely used in the fields such as military affairs, national defence, industry, environment and clinical diagnosis.But due to other in detection environment
The interference of complex matrices such as steam etc. greatly limits its qualitative ability of identification and quantitation capabilities.Gas chromatograph (gas
Chromatograph, GC) it is current universally recognized high efficiency and high stability separating tool, in the separation point of gaseous substance
It is widely used in analysis.In the technology known to utility model people, existing gas-chromatography-ion mobility spectrometry is combined equipment.
Gas-chromatography-ion mobility spectrometry combination equipment purpose is the separation and detection of realization complex material, has both combination equipment
The strong separating capacity of gas chromatograph (gas chromatograph, GC) and high sensitivity, the good resolution of ionic migration spectrometer
And the advantages of response quickly.
Gas-chromatography known to utility model people-ion mobility spectrometry combination usual volume of equipment is big, quality weight, needs to configure
Gas source provides clean chromatography column feed materials carrier gas for gas-chromatography part, and sample, sample introduction is complicated, analysis time is long, limit
Gas-chromatography-ion mobility spectrometry combination equipment application range.
Utility model content
The utility model provides a kind of gas-chromatography-ion mobility spectrometry combination equipment, comprising:
Gas phase chromatographic device, for carrying out pre-separation to measuring samples to form pre-separation sample；
Ion mobility spectrometry apparatus, the communication with the gas phase chromatographic device, for the pre-separation sample
It is detected；With
Recycle gas path module, be in fluid communication with the discharge gas interface of the ion mobility spectrometry apparatus, for by it is described from
The discharge gas of son migration spectral apparatus discharge is handled, and the circulation gas path module also connects with the gas phase chromatographic device gas
It is logical, for the part discharge gas to be delivered to the gas phase chromatographic device as carrier gas, so that the measuring samples are described
Enter the gas phase chromatographic device under the driving effect of carrier gas.
In some embodiments, the circulation gas path module includes discharge air purifying apparatus, the discharge air purifying apparatus
For purifying to the discharge gas, the part discharge gas is the discharge after the discharge air purifying apparatus purification
Gas.
In some embodiments, the circulation gas path module further includes that first row goes out air driving device, first discharge
Air driving device is connected between the discharge gas interface of the ion mobility spectrometry apparatus and the entrance of the discharge air purifying apparatus,
The discharge air purifying apparatus is entered by the discharge gas that the ion mobility spectrometry apparatus is discharged for driving；And/or the circulation
Gas path module further includes that second row goes out air driving device, and the second row goes out air driving device and is set to the discharge gas purification dress
Between the outlet set and the entrance of the gas phase chromatographic device, filled for driving the part that gas is discharged into the gas-chromatography
It sets.
In some embodiments, it includes diaphragm pump that the first row, which goes out air driving device,；And/or the second row outlet
Driving device includes booster pump.
In some embodiments, the circulation gas path module further includes the first buffer unit, and first buffer unit connects
It passes through between the import of discharge gas interface and the discharge air purifying apparatus of the ion mobility spectrometry apparatus, for reducing diaphragm
Disturbance of the pumping gas pulse air-flow to ion mobility spectrometry apparatus internal gas flow；And/or the circulation gas path module further includes second
Buffer unit, second buffer unit are connected to the outlet of the discharge air purifying apparatus and entering for the gas phase chromatographic device
Between mouthful, disturbance of the air pulse to ion mobility spectrometry apparatus internal gas flow is inflated for reducing diaphragm pump.
In some embodiments, first buffer unit includes the first buffering cavity structure and the with the first opening
One buffer film, first buffer film are set to first opening of the first buffering cavity structure to close described
One opening；And/or second buffer unit includes the second buffering cavity structure and the second buffer film with the second opening,
Second buffer film is set to second opening of the second buffering cavity structure to close second opening.
In some embodiments, second buffer unit be also connected to it is described discharge air purifying apparatus outlet with it is described
Between the migration gas entrance of ion mobility spectrometry apparatus, so that one be discharged in gas after the discharge air purifying apparatus purification
Part, which enters among the ion mobility spectrometry apparatus, is used as migration gas.
In some embodiments, the circulation gas path module further includes discharge throughput regulating member, the discharge air-flow
Amount regulating member is set between the import of the discharge air purifying apparatus and the discharge gas interface of the ion mobility spectrometry apparatus,
For adjusting the flow for flowing to the discharge gas of the discharge air purifying apparatus by the ion mobility spectrometry apparatus；And/or it described follows
Ring gas path module further includes carrier gas flux regulating member, and the carrier gas flux regulating member is set to the discharge air purifying apparatus
Outlet and the entrance of the gas phase chromatographic device between, the gas phase color flowed to by the discharge air purifying apparatus for adjusting
The flow of the discharge gas of spectral apparatus.
In some embodiments, the gas-chromatography-ion mobility spectrometry combination equipment further includes sample switch, described
Sample switch includes support construction and semi-permeable membrane, and the support construction has hollow chamber, and the semi-permeable membrane is set to institute
It states in hollow chamber and the hollow chamber is divided into acquisition sample cavity and chromatographic sample chamber, sample enters the acquisition
The measuring samples are formed through entering the chromatographic sample chamber by the semi-permeable membrane after sample cavity；And the circulation gas path module is logical
The entrance for crossing the chromatographic sample chamber and the gas phase chromatographic device is in fluid communication.
In some embodiments, the gas-chromatography-ion mobility spectrometry combination equipment further includes sampling apparatus, the sampling
Device includes sampling driving device and sampling head, described to sample driving device and the sampling head and the sample switch
Sample cavity connection is acquired, the sampling driving device applies attraction to the sample that the sampling head acquires and drives
The sample enters in the acquisition sample cavity.
In some embodiments, the hollow chamber is the shuttle shape chamber that both ends area of section is small, intermediate cross-section area is big,
The acquisition sample cavity has the sample inlet and use for being used to receive the sample for being divided into shuttle shape chamber both ends
In the sample outlet port of discharge sample exhaust gas, the chromatographic sample chamber, which has, is divided into being used for for shuttle shape chamber both ends
Receive the carrier gas inlet to part discharge gas and for exporting measuring samples and described to the gas phase chromatographic device
The sample delivery outlet of the mixture of carrier gas.
In some embodiments, the inner wall of the hollow chamber is equipped with guide groove, and the guide groove is for guiding the acquisition
Sample cavity and/or the chromatographic sample it is intracavitary gas flowing.
In some embodiments, the sample switch further includes semi-transparent film heating device, the semi-permeable membrane heating dress
It sets for being heated to the semi-permeable membrane；And/or the sample switch further includes semi-permeable membrane cooling device, described half
Permeable membrane cooling device realizes enrichment of the sample on semi-permeable membrane for cooling down to the semi-permeable membrane.
In some embodiments, the semi-transparent film heating device carries out PULSE HEATING to the semi-permeable membrane.
In some embodiments, the circulation gas path module includes the communication port being communicated with the atmosphere and flows through institute for purifying
State the connection air purifying apparatus of the gas of communication port.
Gas-chromatography based on the utility model-ion mobility spectrometry is combined equipment, and the drive of gas is discharged in part in measuring samples
Movement enters gas phase chromatographic device with lower, i.e., chromatography column feed materials carrier gas is using clean circulation air, thus gas-chromatography-ion moves
Spectrum combination equipment is moved without external or built-in gas tank so that gas-chromatography-ion mobility spectrometry combination equipment degree of miniaturization and
Portability improves, and can widen gas-chromatography-ion mobility spectrometry combination equipment use environment.
By the way that the exemplary embodiment of the utility model is described in detail referring to the drawings, the utility model its
Its feature and its advantage will become apparent.
Detailed description of the invention
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment
Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
It is some embodiments of the utility model, for those of ordinary skill in the art, before not making the creative labor property
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 shows gas-chromatography-ion mobility spectrometry combination equipment structure and gas circuit original of an embodiment of the present invention
Manage schematic diagram.
Fig. 2 shows the principle schematic diagrams of the support construction of sample switch shown in Fig. 1.
Fig. 3 shows the cross-sectional structure schematic diagram of sample switch shown in Fig. 1.
Into Fig. 3, each appended drawing reference represents Fig. 1:
A, sample；
11, sampling head；12, sampling pump；
2, sample switch；
21, support construction；211, guide groove；I, sample cavity is acquired；II, chromatographic sample chamber；
22, semi-permeable membrane；
23, ceramic heating flake；
31, chromatographic column；
41, migration tube；411, gas entrance is migrated；412, gas interface is discharged；
511, throughput regulating member is discharged；
512, molecular sieve inlet flow rate regulating member；
52, the first buffer unit；521, the first buffering cavity structure；522, the first buffer film；
53, diaphragm pump；
54, three-way connection；
55, air purifying apparatus is discharged；
56, it is connected to air purifying apparatus；
57, the second buffer unit；571, the second buffering cavity structure；572, the second buffer film；
58, booster pump；
591, gas inlet flow rate regulating member is migrated；
592, carrier gas flux regulating member.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Be to the description only actually of at least one exemplary embodiment below it is illustrative, never as to this is practical
Novel and its application or any restrictions used.Based on the embodiments of the present invention, those of ordinary skill in the art are not having
There is every other embodiment obtained under the premise of carrying out creative work, fall within the protection scope of the utility model.
Technology, method and apparatus known to person of ordinary skill in the relevant may be not discussed in detail, but suitable
In the case of, the technology, method and apparatus should be considered as authorizing part of specification.
In the description of the present invention, it should be understood that the noun of locality such as " front, rear, top, and bottom, left and right ", " laterally,
Vertically, vertically, it is horizontal " and " pushing up, bottom " etc. indicated by orientation or positional relationship be normally based on orientation or position shown in the drawings
Relationship is set, is merely for convenience of describing the present invention and simplifying the description, in the absence of explanation to the contrary, these nouns of locality
Do not indicate that and imply that signified device or element must have a particular orientation or be constructed and operated in a specific orientation, because
This should not be understood as the limitation to scope of protection of the utility model；The noun of locality " inside and outside " refers to the wheel relative to each component itself
Wide is inside and outside.
In the description of the present invention, it should be understood that limiting zero using the words such as " first ", " second "
Part, it is only for convenient for distinguishing to corresponding components, there is no Stated otherwise such as, above-mentioned word there is no particular meaning,
Therefore it should not be understood as the limitation to scope of protection of the utility model.
As shown in Figure 1 to Figure 3, the utility model embodiment provides a kind of gas-chromatography-ion mobility spectrometry combination equipment,
It mainly include gas phase chromatographic device, ion mobility spectrometry apparatus and circulation gas path module.Gas phase chromatographic device is used for measuring samples
Pre-separation is carried out to form pre-separation sample.The communication of ion mobility spectrometry apparatus and gas phase chromatographic device, for pair
Pre-separation sample is detected.The discharge gas interface 412 for recycling gas path module and ion mobility spectrometry apparatus is in fluid communication, and is used for
The discharge gas being discharged by ion mobility spectrometry apparatus is handled.Discharge gas is the mixed gas for including carrier gas and migration gas.It follows
Ring gas path module for example buffers discharge gas, is purified and/or recycling processing.Gas path module is recycled also to fill with gas-chromatography
Gas connection is set, for part discharge gas to be delivered to gas phase chromatographic device as carrier gas, so that measuring samples are in the carrier gas
Enter gas phase chromatographic device under driving effect.
In the gas-chromatography-ion mobility spectrometry combination equipment, measuring samples enter under the driving effect of part discharge gas
Gas phase chromatographic device, i.e. chromatography column feed materials carrier gas using clean circulation air, because without it is external or built in gas tank so that gas phase
Chromatography-ion mobility spectrometry combination equipment degree of miniaturization and portability improve, and can widen gas-chromatography-ion mobility spectrometry combination
The use environment of equipment.
Gas phase chromatographic device may include chromatographic column 31 and the chromatographic column heating jacket that is sleeved on outside chromatographic column 31.Chromatographic column
31 can imitate boundling capillary column (Multi-Capillary Columns, MCC) high, that separating capacity is strong for example for column.
Ion mobility spectrometry apparatus for example can be the migration tube 41 of positive and negative double mode, such as can be double using integrated ceramic
Mode migration tube.Ion mobility spectrometry apparatus may be the migration tube of positive or negative single mode.
As shown in Figure 1, in some embodiments, circulation gas path module may include discharge air purifying apparatus 55, discharge gas is net
Makeup sets 55 for purifying to discharge gas, and the aforementioned part discharge gas as carrier gas is to purify through discharge air purifying apparatus 55
Discharge gas later.It can be such as molecular sieve that air purifying apparatus 55, which is discharged,.
As shown in Figure 1, in some embodiments, circulation gas path module may include that first row goes out air driving device, first
Discharge air driving device be connected to ion mobility spectrometry apparatus discharge gas interface 412 and be discharged air purifying apparatus 55 entrance it
Between, it can drive and discharge air purifying apparatus 55 is entered by the discharge gas of ion mobility spectrometry apparatus discharge, purpose is mainly gas
Circulation provides driving force.First row goes out air driving device for example including diaphragm pump 53.
As shown in Figure 1, in some embodiments, circulation gas path module may include that second row goes out air driving device, second
Discharge air driving device is set between the outlet of discharge air purifying apparatus 55 and the entrance of gas phase chromatographic device, due to gas phase color
The vapour lock of spectral apparatus is larger, and second row, which goes out air driving device, can provide additional driving force.
It is preferably booster pump 58 that second row, which goes out air driving device,.It may be diaphragm pump that second row, which goes out air driving device,.
Compared to diaphragm pump, booster pump 58 can provide pressure before the column of higher and more stable chromatographic column 31, therefore
It is more suitable for using the stronger boundling capillary column of separating capacity or capillary chromatograph, to be conducive to improve the detection essence to complex sample
Degree.
As shown in Figure 1, in some embodiments, circulation gas path module may include the first buffer unit 52.First buffering
Device 52 is connected to the discharge gas interface 412 of ion mobility spectrometry apparatus and is discharged between the import of air purifying apparatus 55, can reduce
Diaphragm pump is evacuated disturbance of the air pulse to ion mobility spectrometry apparatus internal gas flow, to improve the steady of ionic migration spectrometer signal
It is qualitative.First buffer unit 52 for example may include the first buffering cavity structure 521 and the first buffer film with the first opening
522, the first buffer film 522 is set to the first opening of the first buffering cavity structure 521 to close the first opening.
Recycling gas path module can also include the second buffer unit 57, and the first end of the second buffer unit 57 is connected to discharge
The second end of the outlet of air purifying apparatus 55, the second buffer unit 57 is connected to (can pass through other component indirect communication) gas-chromatography
The entrance of device, the third end (quantity at third end is not limited to one or two) of the second buffer unit 57 can be communicated to ion and move
The migration gas entrance 411 for moving spectral apparatus can reduce diaphragm pump and inflate air pulse and disturb to ion mobility spectrometry apparatus internal gas flow
It is dynamic, to improve the stability of ionic migration spectrometer signal.Second buffer unit 57 for example may include with the second opening
Second buffering cavity structure 571 and the second buffer film 572, the second buffer film 572 are set to the of the second buffering cavity structure 571
Two openings are to close the second opening.
In the present embodiment, it is provided with buffer unit in the upstream and downstream of diaphragm pump 53, and in hard buffering cavity knot
The opening setting buffer film of structure seals, and the air pulse and booster pump 58 that can reduce diaphragm pump 53 are to Ion transfer
The influence of spectral apparatus interior air-flow and pressure.First buffer film 522 and the second buffer film 572 for example can be good with telescopicing performance
Latex buffer film.
As shown in Figure 1, the second buffer unit 57 is also connected to the outlet of discharge air purifying apparatus 55 and ion mobility spectrometry fills
Between the migration gas entrance 411 set so that through discharge air purifying apparatus 55 purify after discharge gas in a part enter from
It is used as migration gas among son migration spectral apparatus.
In some embodiments, as shown in Figure 1, circulation gas path module can also include discharge throughput regulating member 511,
Discharge throughput regulating member 511 is set to the import of discharge air purifying apparatus 55 and the discharge gas of ion mobility spectrometry apparatus connects
Between mouth 412, for adjusting the flow for flowing to the discharge gas of discharge air purifying apparatus 55 by ion mobility spectrometry apparatus.
Throughput regulating member 511 is discharged due to being arranged, the discharge throughput of the adjustable discharge gas interface of user, and can
It selects only according to the positive and negative attribute of charge to the product ion for it is expected the pre-separation sample detected in holotype or negative mode
In corresponding one mode detected and cut off another mode, or detect simultaneously in positive and negative mode, raising gas phase
Selective enumeration method ability of the chromatography-ion mobility spectrometry combination equipment to sample A.
In some embodiments, as shown in Figure 1, circulation gas path module can also include being arranged in diaphragm pump 53 and molecular sieve
Between molecular sieve inlet flow rate regulating member 512, so as to control enter molecular sieve gas flow.
In some embodiments, it as shown in Figure 1, circulation gas path module can also include carrier gas flux regulating member 592, carries
Throughput regulating member 592 is set between the outlet of discharge air purifying apparatus 55 and the entrance of gas phase chromatographic device, for adjusting
Section is flowed to the flow of the discharge gas of gas phase chromatographic device by discharge air purifying apparatus 55.
In addition, circulation gas path module can also include migration gas inlet flow rate regulating member 591, gas inlet flow rate tune is migrated
Section component 591 is set between the outlet of discharge air purifying apparatus 55 and the migration gas entrance 411 of ion mobility spectrometry apparatus, is used for
Adjust the flow that the discharge gas of ion mobility spectrometry apparatus is flowed to by discharge air purifying apparatus 55.
As shown in Figure 1 to Figure 3, in some embodiments, gas-chromatography-ion mobility spectrometry combination equipment further includes that sample is handed over
Changing device 2.Sample switch 2 includes support construction 21 and semi-permeable membrane 22.Support construction 21 has hollow chamber, semi-permeable membrane 22
It is set in hollow chamber and hollow chamber is divided into acquisition sample cavity I and chromatographic sample chamber II.Sample A, which enters, to be adopted
Through forming measuring samples into chromatographic sample chamber II by semi-permeable membrane 22 after collection sample cavity I.And circulation gas path module passes through chromatography sample
The entrance of product chamber II and gas phase chromatographic device is in fluid communication.
The support construction 21 of sample Switching Module 2 for example can be the aluminum design part of passivated processing.
In some embodiments, it as shown in Figure 1, gas-chromatography-ion mobility spectrometry combination equipment further includes sampling apparatus, adopts
Sampling device includes sampling driving device and sampling head 11.
Sampling driving device and sampling head 11 are connected to the acquisition sample cavity I of sample switch 2.As shown in Figure 1, sampling
Device further includes sample lines, samples driving device and sampling head 11 and is connected to acquisition sample cavity I each by sample lines.
Sampling driving device applies attraction to the sample A that sampling head 11 acquires and sample A is driven to enter acquisition sample cavity
In I.Sampling driving device can be sampling pump 12.
In some embodiments, as shown in Fig. 2, hollow chamber is the shuttle that both ends area of section is small, intermediate cross-section area is big
Shape chamber.Acquisition sample cavity I has the sample inlet for being used to enter sample A for being divided into shuttle shape chamber both ends and for arranging
The sample outlet port of sample exhaust gas out.Chromatographic sample chamber II have be divided into shuttle shape chamber both ends for receiving aforementioned work
The carrier gas inlet of gas is discharged and the mixing for exporting measuring samples and aforementioned carrier gas to gas phase chromatographic device in part for carrier gas
The sample delivery outlet of object.The set-up mode of the hollow chamber of support device 21 can make substantially dead without flowing in hollow chamber
Angle, conducive to sample retention is prevented, first reduction of speed flowing further accelerates outflow after entering corresponding chambers into the indoor fluid of hollow cavity, benefit
In increasing semi-permeable membrane 22 to the effective active area of sample, the cleaning of sample exchange efficiency and sample Switching Module 2 can be improved
Effect.
In some embodiments, as shown in figure 3, the inner wall of the hollow chamber of support construction 21 is equipped with guide groove 211, guide groove
211 for guiding the gas in chromatographic sample chamber II to flow.Fig. 2 shows be that both ends area of section is small, intermediate in hollow chamber
When the big shuttle shape chamber of area of section, trend of each guide groove 211 inside support construction 21.Guide groove 211 can prevent in chamber
Air-flow directly walk shortest path, also be conducive to prevent from moving because sample influences gas-chromatography-ion in corresponding chambers local retention
Move the performance of spectrum combination equipment.
As shown in figure 3, the support device 21 of sample Switching Module 2 is divide into upper part and lower part.Guide groove 211 can be to be set to
The pectination guide groove of upper and lower two parts inner wall is separated between two-part pectination guide groove using semi-permeable membrane 22, up and down thus by hollow
Chamber is divide into upper part and lower part, and middle and upper part is divided into acquisition sample cavity I, and lower part is divided into chromatographic sample chamber II.
In some embodiments, as shown in figure 3, sample switch 2 further includes semi-transparent film heating device, semi-permeable membrane heating
Device is for heating semi-permeable membrane 22.Semi-transparent film heating device for example can carry out PULSE HEATING to semi-permeable membrane 22.
In some embodiments, the settable ceramic heat of two parts up and down of the support construction 21 of sample Switching Module 2
Piece 23 is used as semi-transparent film heating device, and ceramic heating flake 23 is as close to semi-permeable membrane 22, to ensure PULSE HEATING effect.
In some embodiments, sample switch can also include semi-permeable membrane cooling device, and semi-permeable membrane cooling device is used
It is cooled down in semi-permeable membrane 22.Setting semi-permeable membrane cooling device can be such that sample switch and its semi-permeable membrane quickly adjusts
To required temperature, conducive to gas-chromatography-ion mobility spectrometry combination equipment detection efficiency is improved.Semi-permeable membrane cooling device can wrap
Include fan or fluid cooling device etc..
In some embodiments, circulation gas path module may include the communication port being communicated with the atmosphere and for purify the company of flowing through
The connection air purifying apparatus 56 of the gas of port.As shown in Figure 1, to reduce temperature change, ambient pressure variations etc. move ion
The influence for moving spectral apparatus air pressure inside, is provided with three-way connection 54, wherein three-way connection 54 between diaphragm pump 53 and molecular sieve
A termination molecular sieve, the other end ventilates connect atmosphere again after purification device 56 in succession.Have in connection air purifying apparatus 56 and is used for
Purification flows through the cleanser of the gas of communication port.This semi-open setting so that ion mobility spectrometry apparatus can according to environmental change and
Own temperature variation carries out automatic tonifying Qi and loses heart, to reduce influence of the external environment to ion mobility spectrometry apparatus, is conducive to
Improve the service life of molecular sieve.
The gas-chromatography of the present embodiment-ion mobility spectrometry combination equipment needed before sample detection to ion mobility spectrometry apparatus,
Chromatographic column 31 and sample Switching Module 2 are heated.Wherein ion mobility spectrometry apparatus, chromatographic column 31 can be according to sample A
Physicochemical property temperature.Substance detection is being carried out using the gas-chromatography-ion mobility spectrometry combination equipment of the utility model
Input mode sample introduction can be permeated when identification using semi-permeable membrane PULSE HEATING input mode or directly.
Use the concrete operations mode of semi-permeable membrane PULSE HEATING input mode sample introduction can be with are as follows: to keep sample Switching Module 2
In room temperature or it is lower than semipermeable membrane temperature, sampling pump 12 is persistently opened, by sample A vapor enrichment in semi-permeable membrane 22
On, after the completion of sample A enrichment, closes sampling pump 12 or turn down 12 pumping speed of sampling pump, and using ceramic heating flake 23 to sample
Product Switching Module 2 and semi-permeable membrane 22 are rapidly heated and maintain desorption temperature, and the sample A of enrichment is rapid from semi-permeable membrane 22
It is desorbed and penetrates into the chromatographic sample chamber II under semi-permeable membrane 22 and form measuring samples, and again by as the aforementioned of chromatography column feed materials carrier gas
Part be discharged it is airborne enter gas phase chromatographic device and ion mobility spectrometry apparatus tested and analyzed.It is desorbed and can be disconnected after the completion of sample introduction
The power-on switch of the ceramic heating flake 23 of sample Switching Module 2.Fan or fluid cooling device can be used to improve detection efficiency
Equal semi-permeable membranes cooling device is cooled to certain temperature to sample Switching Module 2 to 2 auxiliary temperature-reducing of sample Switching Module, and such as 60 DEG C
And a certain temperature below, next checking matter sample detection can be carried out.
The enrichment that can be achieved on sample A using the advantage of semi-permeable membrane PULSE HEATING input mode sample introduction, can be improved
Gas-chromatography-ion mobility spectrometry combination equipment detection sensitivity.Simultaneously, moreover it is possible to realize the rapid osmotic of sample A, improve
The consistency of sample injection time, and then improve the chromatographic resolution rate of test sample.
When using directly infiltration input mode sample introduction, take keep at quarter sample Switching Module 2 and its semi-permeable membrane 22 be in compared with
Under high temperature condition, 2 temperature of sample Switching Module is optionally set in 100 DEG C or more.It is when sample detecting that sampling head 11 is right
Sampling pump 12 is opened after quasi- and close article to be checked, the sampled head 11 of sample A enters sampling conduit, and sampled pipeline reaches
Sample Switching Module 2, semi-permeable membrane 22 in sample Switching Module 2 can effectively by sample A steam and ammonia be blocked in
Outside semi-permeable membrane 22, and test sample is penetrated into rapidly in chromatographic sample chamber II, and chromatographic column 31 is brought by chromatography column feed materials carrier gas
Formation pre-separation sample, which enters back into ion mobility spectrometry apparatus, after progress pre-separation is tested and analyzed.
Advantage using direct infiltration input mode is detection efficiency height, but too late for low concentration sample A detection effect
Using semi-permeable membrane PULSE HEATING input mode.
From the above description, it can be seen that gas-chromatography provided by the embodiment of the utility model-ion mobility spectrometry is combined equipment, tool
There is at least one following technical effect:
Chromatography column feed materials carrier gas uses clean circulation air without external or built-in gas tank, so that gas-chromatography-ion
Migration spectrum is combined the degree of miniaturization of equipment and portability improves, and can widen gas-chromatography-ion mobility spectrometry use environment.
Joint semipermeable membrane input mode is sampled using air-breathing, without carrying out destructive sampling, and nothing to test sample A
Pre-treatment need to be carried out to sample A, and directly air-breathing samples and semi-permeable membrane 22 is utilized to permeate sample introduction, so as to sample A
The sample detection time shortened dramatically compared to conventional gas phase chromatography-ion mobility spectrometry combination equipment, improve to sample
The detection efficiency of A, and it is able to achieve the quick detection to complicated sample A, gas-chromatography-ion mobility spectrometry combination can be widened
The application field of equipment.
Gas circuit and flexible buffer device are recycled using semi open model, can according to use environment and operating status automatically with the external world
Air pressure keeps balance, to reduce influence of the pressure change to spectral peak and detection accuracy.
The foregoing is merely the exemplary embodiments of the utility model, are not intended to limit the utility model, all in this reality
Within novel spirit and principle, any modification, equivalent replacement, improvement and so on should be included in the utility model
Within protection scope.
Claims (15)
1. a kind of gas-chromatography-ion mobility spectrometry is combined equipment characterized by comprising
Gas phase chromatographic device, for carrying out pre-separation to measuring samples to form pre-separation sample；
Ion mobility spectrometry apparatus, the communication with the gas phase chromatographic device, for being carried out to the pre-separation sample
Detection；With
Recycle gas path module, be in fluid communication with the discharge gas interface (412) of the ion mobility spectrometry apparatus, for by it is described from
The discharge gas of son migration spectral apparatus discharge is handled, and the circulation gas path module also connects with the gas phase chromatographic device gas
It is logical, for the part discharge gas to be delivered to the gas phase chromatographic device as carrier gas, so that the measuring samples are described
Enter the gas phase chromatographic device under the driving effect of carrier gas.
2. gas-chromatography according to claim 1-ion mobility spectrometry is combined equipment, which is characterized in that the circulation gas circuit
Module includes discharge air purifying apparatus (55), and the discharge air purifying apparatus (55) is for purifying the discharge gas, institute
Stating part discharge gas is the discharge gas after discharge air purifying apparatus (55) purification.
3. gas-chromatography according to claim 2-ion mobility spectrometry is combined equipment, which is characterized in that the circulation gas circuit
Module further includes that first row goes out air driving device, and the first row goes out air driving device and is connected to the ion mobility spectrometry apparatus
It is discharged between gas interface (412) and the entrance of discharge air purifying apparatus (55), is filled for driving by the ion mobility spectrometry
The discharge gas for setting discharge enters the discharge air purifying apparatus (55)；And/or the circulation gas path module further includes the second discharge
Air driving device, the second row go out the outlet and the gas phase that air driving device is set to discharge air purifying apparatus (55)
Between the entrance of chromatogram arrangement, for driving the part discharge gas to enter the gas phase chromatographic device.
4. gas-chromatography according to claim 3-ion mobility spectrometry is combined equipment, which is characterized in that first discharge
Air driving device includes diaphragm pump (53)；And/or it includes booster pump (58) that the second row, which goes out air driving device,.
5. gas-chromatography according to claim 2-ion mobility spectrometry is combined equipment, which is characterized in that the circulation gas circuit
Module further includes the first buffer unit (52), and first buffer unit (52) is connected to the discharge of the ion mobility spectrometry apparatus
Between gas interface (412) and the import of discharge air purifying apparatus (55), the pumping of air driving device is gone out for reducing first row
Disturbance of the gas pulse air-flow to ion mobility spectrometry apparatus internal gas flow；And/or the circulation gas path module further includes the second buffering
Device (57), second buffer unit (57) are connected to the outlet that air purifying apparatus (55) are discharged and the Ion transfer
Between the migration gas entrance (411) of spectral apparatus, the air pulse of inflating for going out air driving device for reducing first row moves ion
Move the disturbance of spectral apparatus internal gas flow.
6. gas-chromatography according to claim 5-ion mobility spectrometry is combined equipment, which is characterized in that first buffering
Device (52) includes the first buffering cavity structure (521) and the first buffer film (522) with the first opening, first buffering
Film (522) is set to first opening of the first buffering cavity structure (521) to close first opening；With/
Or, second buffer unit (57) includes the second buffering cavity structure (571) and the second buffer film with the second opening
(572), second buffer film (572) is set to second opening of the second buffering cavity structure (571) to seal
Close second opening.
7. gas-chromatography according to claim 5-ion mobility spectrometry is combined equipment, which is characterized in that second buffering
Device (57) is also connected to outlet and the migration gas entrance of the ion mobility spectrometry apparatus of discharge air purifying apparatus (55)
(411) between, so that a part being discharged in gas after discharge air purifying apparatus (55) purification enters the ion
It migrates and is used as migration gas among spectral apparatus.
8. gas-chromatography according to claim 2-ion mobility spectrometry is combined equipment, which is characterized in that the circulation gas circuit
Module further includes discharge throughput regulating member (511), and the discharge throughput regulating member (511) is set to the discharge gas
Between the import of purification device (55) and the discharge gas interface (412) of the ion mobility spectrometry apparatus, for adjust by it is described from
Son migration spectral apparatus flows to the flow of the discharge gas of discharge air purifying apparatus (55)；And/or the circulation gas path module is also
Including carrier gas flux regulating member (592), the carrier gas flux regulating member (592) is set to the discharge air purifying apparatus
(55) export between the entrance of the gas phase chromatographic device, flows to institute by the discharge air purifying apparatus (55) for adjusting
State the flow of the discharge gas of gas phase chromatographic device.
9. -8 any gas-chromatography-ion mobility spectrometries are combined equipment according to claim 1, which is characterized in that the gas
Phase chromatography-ion mobility spectrometry combination equipment further includes sample switch (2), and the sample switch (2) includes support knot
Structure (21) and semi-permeable membrane (22), the support construction (21) have hollow chamber, and the semi-permeable membrane (22) is set to described hollow
In chamber and the hollow chamber is divided into and acquires sample cavity (I) and chromatographic sample chamber (II), described in sample (A) entrance
Acquisition sample cavity (I) forms the measuring samples into the chromatographic sample chamber (II) by by the semi-permeable membrane (22)；And institute
Circulation gas path module is stated to be in fluid communication by the entrance of the chromatographic sample chamber (II) and the gas phase chromatographic device.
10. gas-chromatography according to claim 9-ion mobility spectrometry is combined equipment, which is characterized in that the gas phase color
Spectrum-ion mobility spectrometry combination equipment further includes sampling apparatus, and the sampling apparatus includes sampling driving device and sampling head (11),
The sampling driving device and the sampling head (11) are connected to the acquisition sample cavity (I) of the sample switch (2), described
Sampling driving device applies attraction to the sample (A) that the sampling head (11) acquires and drives the sample
(A) enter in the acquisition sample cavity (I).
11. gas-chromatography according to claim 9-ion mobility spectrometry is combined equipment, which is characterized in that the hollow chamber
For the shuttle shape chamber that both ends area of section is small, intermediate cross-section area is big, the acquisition sample cavity (I), which has, is divided into the shuttle shape
The sample inlet for receiving the sample (A) at chamber both ends and the sample exhaust gas discharge for sample exhaust gas to be discharged
Mouthful, the chromatographic sample chamber (II) has the carrier gas that gas is discharged for receiving the part for being divided into shuttle shape chamber both ends
The sample delivery outlet of entrance and the mixture for exporting the measuring samples and the carrier gas to the gas phase chromatographic device.
12. gas-chromatography according to claim 9-ion mobility spectrometry is combined equipment, which is characterized in that the hollow chamber
Inner wall be equipped with guide groove (211), the guide groove (211) is for guiding the acquisition sample cavity (I) and/or the chromatographic sample
Gas flowing in chamber (II).
13. gas-chromatography according to claim 9-ion mobility spectrometry is combined equipment, which is characterized in that the sample exchange
Device (2) further includes semi-transparent film heating device, and the semi-transparent film heating device is for heating the semi-permeable membrane (22)；
And/or the sample switch (2) further includes semi-permeable membrane cooling device, the semi-permeable membrane cooling device is used for described half
Permeable membrane (22) is cooled down, and realizes example enrichment.
14. gas-chromatography according to claim 13-ion mobility spectrometry is combined equipment, which is characterized in that the semi-permeable membrane
Heating device carries out PULSE HEATING to the semi-permeable membrane (22).
15. -8 any gas-chromatography-ion mobility spectrometries are combined equipment according to claim 1, which is characterized in that described to follow
Ring gas path module includes the communication port that is communicated with the atmosphere to be flowed through the gas of the communication port and is connected to gas purification dress with for purifying
Set (56).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822122141.7U CN209542533U (en) | 2018-12-18 | 2018-12-18 | Gas-chromatography-ion mobility spectrometry is combined equipment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822122141.7U CN209542533U (en) | 2018-12-18 | 2018-12-18 | Gas-chromatography-ion mobility spectrometry is combined equipment |
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| CN209542533U true CN209542533U (en) | 2019-10-25 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109307724A (en) * | 2018-12-18 | 2019-02-05 | 同方威视技术股份有限公司 | Gas-chromatography-ion mobility spectrometry is combined equipment |
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2018
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109307724A (en) * | 2018-12-18 | 2019-02-05 | 同方威视技术股份有限公司 | Gas-chromatography-ion mobility spectrometry is combined equipment |
| GB2580538A (en) * | 2018-12-18 | 2020-07-22 | Nuctech Co Ltd | Gas chromatograph-ion mobility spectrometry combined equipment |
| GB2580538B (en) * | 2018-12-18 | 2021-05-05 | Nuctech Co Ltd | Gas chromatograph-ion mobility spectrometry combined equipment |
| US11320407B2 (en) | 2018-12-18 | 2022-05-03 | Nuctech Company Limited | Gas chromatograph-ion mobility spectrometry combined equipment |
| CN109307724B (en) * | 2018-12-18 | 2024-10-18 | 同方威视技术股份有限公司 | Gas chromatography-ion mobility spectrometry combined equipment |
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