CN106333937B - Plaster matrix with large drug loading and high sustained viscosity - Google Patents

Plaster matrix with large drug loading and high sustained viscosity Download PDF

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CN106333937B
CN106333937B CN201610763985.2A CN201610763985A CN106333937B CN 106333937 B CN106333937 B CN 106333937B CN 201610763985 A CN201610763985 A CN 201610763985A CN 106333937 B CN106333937 B CN 106333937B
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parts
weight
plaster
matrix
large drug
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CN106333937A (en
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蔡玉安
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

The invention relates to the field of pharmacy, in particular to a novel special matrix for a plaster with large drug-loading rate and high sustained viscosity. Aiming at the problems in the prior art, the invention aims to provide a novel special plaster matrix with large drug-loading rate and high delayed viscosity, which is prepared from 8 parts by weight of honey, 6 parts by weight of beeswax, 6 parts by weight of xanthan gum, 2 parts by weight of vaporized rosin, 2 parts by weight of medical vaseline, 2 parts by weight of glyceryl monostearate, 2 parts by weight of cosmetic white oil No. 26, 2 parts by weight of medical glycerin, 2 parts by weight of polyethylene glycol 40002, 2 parts by weight of oleamide, 2 parts by weight of laurocapram, 2 parts by weight of zinc oxide, 2 parts by weight of light calcium carbonate and 8 parts by weight of talcum powder serving as plaster matrix base materials. The plaster substrate of the invention has the following advantages: the patch is nontoxic, does not irritate skin, has high application freedom, does not cause the phenomena of flowing and residue on local parts, is green and healthy, has no toxic or side effect on human bodies, and is suitable for long-term application.

Description

Plaster matrix with large drug loading and high sustained viscosity
Technical Field
The invention relates to the field of pharmacy, in particular to a novel special matrix for a plaster with large drug-loading rate and high sustained viscosity.
Background
The patch is a sheet-like preparation which is adhered to the skin and can produce systemic or local effect. The patch can be applied to an intact skin surface, or to an affected or incomplete skin surface.
The external patch consists of a matrix capable of bearing a medicament and a medicament with related pharmacological activity. The existing traditional black plaster matrix mainly comprising red lead, various rubber plaster matrices mainly comprising hot melt adhesive or rubber and modified rosin plaster matrices mainly comprising rosin and mixed with the hot melt adhesive have various defects and shortcomings.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to provide a novel special matrix for a plaster with large drug loading capacity and high sustained viscosity
The technical scheme for solving the problems is as follows:
a novel special matrix for a plaster with large drug loading and high sustained viscosity is prepared from 8 parts by weight of honey, 6 parts by weight of beeswax, 6 parts by weight of xanthan gum, 2 parts by weight of vaporized rosin, 2 parts by weight of medical vaseline, 2 parts by weight of glyceryl monostearate, 2 parts by weight of cosmetic white oil No. 26, 2 parts by weight of medical glycerin, 40002 parts by weight of polyethylene glycol, 2 parts by weight of oleamide, 2 parts by weight of laurocapram, 2 parts by weight of zinc oxide, 2 parts by weight of light calcium carbonate and 8 parts by weight of talcum powder serving as a base material of the plaster matrix.
The preparation method comprises the following steps: heating the matrix material to 90 ℃ in a closed manner, fully mixing and uniformly stirring to prepare a sticky plaster matrix with certain fluidity; the matrix can be added with the following dispersed matrix: the traditional Chinese medicine original medicinal material superfine powder with the weight ratio of 48:52 is stirred, so that the external plaster with the original medicinal material content of more than 50 percent is finally prepared.
The plaster substrate of the invention has the following advantages:
firstly, a large amount of minium components contained in the traditional plaster are removed, and the minium is a heavy metal which is toxic to human bodies, is very easy to stimulate skin to cause allergy, is greatly influenced by temperature difference, and is easy to flow and remain locally. Secondly, a large amount of rubber components contained in the hot melt adhesive plaster are removed, the rubber is easy to cause allergy, the drug-loading rate is low, the drug effect is not easy to release, and the xanthan gum used in the invention is edible monad polysaccharide generated by biological fermentation, but not rubber.
And thirdly, a large amount of rosin components contained in the rosin plaster are removed, but a large amount of rosin is easy to stimulate the skin to cause allergy and is easy to flow and remain locally.
And fourthly, the plaster has the free application freedom of sticking and pulling, particularly the holding viscosity is more than 10 times stronger than that of the plaster made of other matrixes, and the phenomena of flowing and residual can not occur on the local part.
Fifth, the anaphylaxis rate is very low, and the anaphylaxis phenomenon hardly occurs.
And sixthly, the plaster is green and healthy, has no toxic or side effect on a human body, and is suitable for long-term application.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
A novel matrix special for a plaster with large drug loading and high sustained viscosity is prepared by heating matrix materials of 8g of honey, 6 parts of beeswax, 6g of xanthan gum, 2g of vaporized rosin, 2g of medical vaseline, 2g of glyceryl monostearate, 2g of white oil for 26 # cosmetics, 2g of medical glycerin, 40002 g of polyethylene glycol, 2g of oleamide, 2g of laurocapram, 2g of zinc oxide, 2g of light calcium carbonate and 8g of talcum powder to 90 ℃ in a sealed manner, fully mixing and uniformly stirring to prepare a sticky plaster matrix with certain fluidity, and adding 52g of traditional Chinese medicine crude drug ultrafine powder into the matrix for stirring, thereby finally preparing an external plaster with the crude drug content of 52%.
The physical and chemical properties of the plasters with four different matrixes are shown in a comparison table:
Figure GDA0002057099830000031

Claims (1)

1. a plaster matrix with large drug loading and high sustained viscosity is prepared from the following components in parts by weight: 8 parts of honey, 6 parts of beeswax, 6 parts of xanthan gum, 2 parts of vaporized rosin, 2 parts of medical vaseline, 2 parts of glyceryl monostearate, 2 parts of cosmetic 26 white oil, 2 parts of medical glycerin, 2 parts of polyethylene glycol 40002, 2 parts of oleamide, 2 parts of laurocapram, 2 parts of zinc oxide, 2 parts of light calcium carbonate and 8 parts of talcum powder which are taken as plaster matrix base materials,
the preparation method comprises the following steps: heating the matrix material to 90 deg.C under sealed condition, mixing, and stirring to obtain viscous and fluid matrix for plaster.
CN201610763985.2A 2016-08-30 2016-08-30 Plaster matrix with large drug loading and high sustained viscosity Active CN106333937B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
CN201610763985.2A CN106333937B (en) 2016-08-30 2016-08-30 Plaster matrix with large drug loading and high sustained viscosity

Publications (2)

Publication Number Publication Date
CN106333937A CN106333937A (en) 2017-01-18
CN106333937B true CN106333937B (en) 2020-04-28

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113384561B (en) * 2021-08-11 2021-11-30 寿光市中医医院 Allergy-free dysmenorrhea patch and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1130079A (en) * 1995-03-01 1996-09-04 上海市伤骨科研究所 Adhesive plaster for alleviating pain and detumescence
CN1144655A (en) * 1995-05-18 1997-03-12 湖北药检高等专科学校 Indomethacin adhesive plaster
CN1201663A (en) * 1997-06-10 1998-12-16 海内胜 Substrate for medical paste
CN105055700A (en) * 2015-09-01 2015-11-18 宋阳 Rheumatic arthritis plaster and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1130079A (en) * 1995-03-01 1996-09-04 上海市伤骨科研究所 Adhesive plaster for alleviating pain and detumescence
CN1144655A (en) * 1995-05-18 1997-03-12 湖北药检高等专科学校 Indomethacin adhesive plaster
CN1201663A (en) * 1997-06-10 1998-12-16 海内胜 Substrate for medical paste
CN105055700A (en) * 2015-09-01 2015-11-18 宋阳 Rheumatic arthritis plaster and preparation method thereof

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