CN103877590B - A kind of New Pressure-Sensitive Adhesion medium carrier for the preparation of SHUFU TIEGAO and the application in preparation SHUFU TIEGAO thereof - Google Patents
A kind of New Pressure-Sensitive Adhesion medium carrier for the preparation of SHUFU TIEGAO and the application in preparation SHUFU TIEGAO thereof Download PDFInfo
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- CN103877590B CN103877590B CN201410154923.2A CN201410154923A CN103877590B CN 103877590 B CN103877590 B CN 103877590B CN 201410154923 A CN201410154923 A CN 201410154923A CN 103877590 B CN103877590 B CN 103877590B
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Abstract
The present invention relates to for the preparation of the New Pressure-Sensitive Adhesion medium carrier of SHUFU TIEGAO and the application in preparation SHUFU TIEGAO thereof, can effectively solve patient stick after stimulation, anaphylaxis, be beneficial to patient use and healthy problem, method is, pressure sensitive adhesive matrix carrier is by weight percent meter: medical thermoplastic elastomer (TPE) 39-46%, medical tackifying resin 15-29%, medical softening agent liquid paraffin 20-38%, filler zinc oxide 4-7%, antioxidant 1% form; This SHUFU TIEGAO is made up of medicine and pressure sensitive adhesive matrix carrier mix homogeneously, the percentage by weight of medicine and New Pressure-Sensitive Adhesion medium carrier is medicine 17.5-18.2%, substrate 81.8-82.5%, described medicine is weight percentage: Rhizoma Zingiberis Recens cream 30-40%, Camphora 50-60% and Mentholum 5-10% mix composition, prescription of the present invention is novel unique, effectively prevent the stimulation of original SHUFU TIEGAO and sensitization and the patient caused sticks stimulation and the anaphylaxis problem of rear various degrees, be very beneficial for the use of patient and healthy.
Description
Technical field
The present invention relates to medicine, particularly a kind of New Pressure-Sensitive Adhesion medium carrier for the preparation of SHUFU TIEGAO and the application in preparation SHUFU TIEGAO thereof.
Background technology
At present, in the traditional matrices composition of raw materials of the SHUFU TIEGAO product use of domestic production, containing easily causing skin allergy, affecting the stable raw material of storage of finished products, clinical practice easily causes allergic reaction, and the oxidizable mistake of rubber cement of preparation is glutinous and finished product stability fluctuation is large.Due to stimulation and the sensitization of the substrate such as natural rubber, different stimulations and anaphylaxis is there is after causing consumer to stick, be unfavorable for the use of patient and healthy, its reason is to use a large amount of organic solvents in traditional matrices, evaporate completely preparing drying course cannot collect again, cause mass energy to waste, and cause production cost constantly to increase along with resource increasing price of raw materials in recent years.Therefore, carrying out improvement and bring new ideas to the substrate of existing SHUFU TIEGAO, thus prepare novel SHUFU TIEGAO, is the technical problem that must solve.
Summary of the invention
For above-mentioned situation, for overcoming the defect of prior art, the object of the present invention is just to provide a kind of New Pressure-Sensitive Adhesion medium carrier for the preparation of SHUFU TIEGAO and the application in preparation SHUFU TIEGAO thereof, can effectively solve patient stick after stimulation, anaphylaxis, be beneficial to patient and use and healthy problem.
The technical scheme that the present invention solves is that New Pressure-Sensitive Adhesion medium carrier of the present invention is by weight percent meter: medical thermoplastic elastomer (TPE) 39-46%, medical tackifying resin 15-29%, medical softening agent liquid paraffin 20-38%, filler zinc oxide 4-7%, antioxidant 1% form; Wherein, by thermoplastic elastomer (TPE), medical softening agent liquid paraffin, antioxidant 120-130 DEG C of heated and stirred, after mix homogeneously, add medical tackifying resin, filler zinc oxide, 110-120 DEG C of heated and stirred, mix homogeneously;
Described thermoplastic elastomer is the block copolymer (being called for short SIS) of styrene-isoprene-phenylethene and the compositions of natural rubber; Described medical tackifying resin is one or more compositionss of terpene resin, C5 Petropols, C5 hydrogenated petroleum resin, natural rosin, rosin glyceride and derivant, polyisobutylene; Described antioxidant is BHT1010, the one of 2,6 ditertiary butyl p cresol or two kinds of compositionss;
The application of New Pressure-Sensitive Adhesion medium carrier in preparation SHUFU TIEGAO, this SHUFU TIEGAO is made up of medicine and New Pressure-Sensitive Adhesion medium carrier mix homogeneously, the percentage by weight of medicine and New Pressure-Sensitive Adhesion medium carrier is medicine 17.5-18.2%, substrate 81.8-82.5%, described medicine is weight percentage: Rhizoma Zingiberis Recens cream 30-40%, Camphora 50-60% and Mentholum 5-10% mix composition, and to be Rhizoma Zingiberis fine powder with medical ventolin mix homogeneously with 1 ︰ 1 weight ratio described Rhizoma Zingiberis Recens cream forms; Wherein first ginger powder is broken into fine powder, adds medical ventolin, heated and stirred evenly becomes Rhizoma Zingiberis Recens cream, again Camphora, Mentholum are mixed into camphomenthol's cream, Rhizoma Zingiberis Recens cream, camphomenthol's cream and New Pressure-Sensitive Adhesion medium carrier mix, and stir, SHUFU TIEGAO.
Prescription of the present invention is novel unique, particularly adopt Novel pressure-sensitive gel matrix as pharmaceutical carrier, this is the core that the present invention innovates, effectively prevent the stimulation of original SHUFU TIEGAO and sensitization and the patient caused sticks stimulation and the anaphylaxis problem of rear various degrees, being very beneficial for the use of patient and healthy, is the innovation in SHUFU TIEGAO.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is elaborated.
Embodiment 1
The present invention is in concrete enforcement, and described New Pressure-Sensitive Adhesion medium carrier is by weight percent meter: medical thermoplastic elastomer (TPE) 46%, medical tackifying resin 29%, medical softening agent liquid paraffin 20%, filler zinc oxide 4%, antioxidant 1% form; Wherein, by thermoplastic elastomer (TPE) SIS, medical softening agent liquid paraffin, antioxidant 120-130 DEG C of heated and stirred, after mix homogeneously, add medical tackifying resin, filler zinc oxide, 110-120 DEG C of heated and stirred, mix homogeneously;
Embodiment 2
The present invention is in concrete enforcement, New Pressure-Sensitive Adhesion medium carrier is by weight percent meter: medical thermoplastic elastomer (TPE) 41%, medical tackifying resin 20%, medical softening agent liquid paraffin 32%, filler zinc oxide 6%, antioxidant 1% form, and preparation method is with embodiment 1.
Embodiment 3
The present invention is in concrete enforcement, described New Pressure-Sensitive Adhesion medium carrier is by weight percent meter: medical thermoplastic elastomer (TPE) 39%, medical tackifying resin 15%, medical softening agent liquid paraffin 38%, filler zinc oxide 7%, antioxidant 1% form, and preparation method is with embodiment 1.
Embodiment 4
The present invention is in concrete enforcement, the application of described New Pressure-Sensitive Adhesion medium carrier in preparation SHUFU TIEGAO, this SHUFU TIEGAO is made up of the medicine 17.5% of mass ratio range and New Pressure-Sensitive Adhesion medium carrier 82.5%, described medicine is weight percentage: Rhizoma Zingiberis Recens cream 30%, Camphora 60% and Mentholum 10% mix composition, wherein Rhizoma Zingiberis Recens cream is mixed with the weight ratio of 1 ︰ 1 by ginger powder and medical ventolin, heated and stirred is uniformly dispersed and makes, and then by Camphora, Mentholum is mixed into camphomenthol's cream, again Rhizoma Zingiberis Recens cream is mixed homogeneously with camphomenthol's cream and hot-fusible pressure-sensitive adhesive medium carrier, .
Embodiment 5
The present invention is in concrete enforcement, the application of described New Pressure-Sensitive Adhesion medium carrier in preparation SHUFU TIEGAO, also can be made up of the medicine 18.2% of mass ratio range and New Pressure-Sensitive Adhesion medium carrier 81.8%, described medicine is weight percentage: Rhizoma Zingiberis Recens cream 35%, Camphora 58% and Mentholum 7% mixing composition, preparation method is with embodiment 4.
Embodiment 6
The present invention is in concrete enforcement, the application of described New Pressure-Sensitive Adhesion medium carrier in preparation SHUFU TIEGAO, also can be made up of the medicine 18% of mass ratio range and New Pressure-Sensitive Adhesion medium carrier 82%, described medicine is weight percentage: Rhizoma Zingiberis Recens cream 40%, Camphora 55% and Mentholum 5% mixing composition; Preparation method is with embodiment 4.
Embodiment 7
The present invention, in concrete enforcement, also can provide by with under type:
(1) get Rhizoma Zingiberis 38.8g and be ground into fine powder, add 38.8g medical ventolin heated and stirred and be uniformly dispersed, obtain the first mixture;
(2) get Camphora 124.2g, Mentholum 15.5g mix homogeneously, obtain the second mixture;
(3) take thermoplastic elastomer (TPE), medical liquid paraffin, antioxidant, be placed in kneader 120 DEG C ~ 130 DEG C heated and stirred, mix homogeneously, obtains the 3rd mixture;
(4) add medical tackifying resin, filler, be placed in kneader 110 DEG C ~ 120 DEG C heated and stirred, mix homogeneously, obtains 4 mixture;
(5) the first mixture and the second mixture are stirred, resulting mixture A; 3rd mixture, 4 mixture are stirred, resulting mixture B, mixture A and mixture B stir again, SHUFU TIEGAO of the present invention.
Embodiment 8
The present invention in the specific implementation, also can be made up as raw material of styrene-isoprene-phenylethene (SIS) 400g, natural rubber 60g, liquid paraffin 200g, C5 hydrogenated petroleum resin 200g, natural rosin 90g, zinc oxide 40g, BHT101010g of New Pressure-Sensitive Adhesion medium carrier, get Rhizoma Zingiberis 38.8g and be ground into fine powder, add 38.8g medical ventolin heated and stirred to be uniformly dispersed, become the first mixture; Get Camphora 124.2g, Mentholum 15.5g mix homogeneously, become the second mixture; Take thermoplastic elastomer (TPE) SIS400g, natural rubber 60g, medical liquid paraffin 200g, BHT101010g, be placed in kneader 125 DEG C of heated and stirred 60 minutes, mix homogeneously; Add C5 hydrogenated petroleum resin 200g, natural rosin 90g, zinc oxide 40g, be placed in kneader 115 DEG C of heated and stirred 30 minutes, mix homogeneously; Add the first mixture and the second mixture, be placed in kneader 100 DEG C of heated and stirred 20 minutes, mixing and stirring, makes SHUFU TIEGAO of the present invention.
Embodiment 9
The present invention is in concrete enforcement, can also styrene-isoprene-phenylethene (SIS) 360g, natural rubber 60g, liquid paraffin 310g, terpene resin 80g, rosin glyceride 100g, natural rosin 20g, zinc oxide 60g, BHT101010g make as raw material, its preparation method is: get Rhizoma Zingiberis 38.8g and be ground into impalpable powder, add 38.8g medical ventolin heated and stirred to be uniformly dispersed, the first mixture; Get Camphora 124.2g, Mentholum 15.5g mix homogeneously, the second mixture; Take thermoplastic elastomer (TPE) SIS360g, natural rubber 60g, medical liquid paraffin 310g, BHT101010g, be placed in kneader 125 DEG C of heated and stirred 60 minutes, mix homogeneously; Add terpene resin 80g, rosin glyceride 100g, natural rosin 20g, zinc oxide 60g, be placed in kneader 115 DEG C of heated and stirred 30 minutes, mix homogeneously; Add the first mixture and the second mixture, be placed in kneader 100 DEG C of heated and stirred 20 minutes, mixing and stirring, makes SHUFU TIEGAO of the present invention.
Embodiment 10
The present invention is in concrete enforcement, also can be made up as raw material of styrene-isoprene-phenylethene (SIS) 335g, natural rubber 55g, liquid paraffin 380g, C5 hydrogenated petroleum resin 80g, rosin glyceride 40g, natural rosin 30g, zinc oxide 70g, BHT101010g, its preparation method is: get Rhizoma Zingiberis 38.8g and be ground into impalpable powder, add 38.8g medical ventolin heated and stirred to be uniformly dispersed, the first mixture; Get Camphora 124.2g, Mentholum 15.5g mix homogeneously, the second mixture; Take thermoplastic elastomer (TPE) SIS335g, natural rubber 55g, medical liquid paraffin 380g, BHT101010g, be placed in kneader 125 DEG C of heated and stirred 60 minutes, mix homogeneously; Add C5 hydrogenated petroleum resin 80g, rosin glyceride 40g, natural rosin 30g, zinc oxide 70g, be placed in kneader 115 DEG C of heated and stirred 30 minutes, mix homogeneously; Add the first mixture and the second mixture, be placed in kneader 100 DEG C of heated and stirred 20 minutes, mixing and stirring, makes SHUFU TIEGAO of the present invention.
As can be seen from above-mentioned, the present invention is compared with existing SHUFU TIEGAO, maximum difference is, adopt Novel pressure-sensitive gel matrix as pharmaceutical carrier, effectively overcome zest and anaphylaxis that traditional matrices brings, obviously be better than existing SHUFU TIEGAO, fundamentally solve SHUFU TIEGAO and there is zest, anaphylaxis problem, being very beneficial for patient sticks with healthy, be particularly conducive to the use of child, the present invention is effective to gastric abscess, abdominal pain and distension, feel sick, vomiting, inappetence, borborygmus are suffered from diarrhoea, infantile diarrhea, identical with traditional SHUFU TIEGAO scope of application, the object of the invention is to the zest overcoming traditional SHUFU TIEGAO, anaphylaxis, ensure effective use of SHUFU TIEGAO, be beneficial to the rehabilitation of patient and healthy, through being suitable for 159 patients, be divided into 3 groups at random, often organize 53 people, test group adopts SHUFU TIEGAO of the present invention, contrast groups adopts two groups of different existing SHUFU TIEGAO, regarding assay data is as follows:
different SHUFU TIEGAO irritation test result
different SHUFU TIEGAO skin hypersensitivity result of the test
Can clearly be found out by upper table, nonirritant of the present invention, and sensitization also reduces greatly, almost without anaphylaxis, fundamentally solve zest, anaphylaxis problem that SHUFU TIEGAO exists.
different SHUFU TIEGAO process ration and the performance test results are investigated
The present invention in the feed not with an organic solvent, prevents the side effect that organic solvent produces.
different SHUFU TIEGAO permeability test result
Permeability test result shows, SHUFU TIEGAO of the present invention has better permeability than commercially available SHUFU TIEGAO product, more comfortable after sticking.
In a word, experimental data clearly shows, the present invention compared with prior art, provides a kind of SHUFU TIEGAO be made up of New Pressure-Sensitive Adhesion medium carrier, and the stimulation after effective solution patient sticks, anaphylaxis, be beneficial to child especially and use.This using Novel pressure-sensitive gel matrix as pharmaceutical carrier, fundamentally solve skin irritation, hypersensitive problem, be obviously better than existing SHUFU TIEGAO, be that one in SHUFU TIEGAO is innovated greatly, economic and social benefit is remarkable.
Claims (5)
1. the New Pressure-Sensitive Adhesion medium carrier for the preparation of SHUFU TIEGAO, it is characterized in that, by weight percent meter: medical thermoplastic elastomer (TPE) 39-46%, medical tackifying resin 15-29%, medical softening agent liquid paraffin 20-38%, filler zinc oxide 4-7%, antioxidant 1% form; Wherein, by thermoplastic elastomer (TPE), medical softening agent liquid paraffin, antioxidant 120-130 DEG C of heated and stirred, after mix homogeneously, add medical tackifying resin, filler zinc oxide, 110-120 DEG C of heated and stirred, mix homogeneously;
Described thermoplastic elastomer is the block copolymer of styrene-isoprene-phenylethene and the compositions of natural rubber; Described medical tackifying resin is one or more compositionss of terpene resin, C5 Petropols, C5 hydrogenated petroleum resin, rosin glyceride, polyisobutylene; Described antioxidant is BHT1010, the one of 2,6 ditertiary butyl p cresol or two kinds of compositionss.
2. the New Pressure-Sensitive Adhesion medium carrier for the preparation of SHUFU TIEGAO according to claim 1, it is characterized in that, described New Pressure-Sensitive Adhesion medium carrier is by weight percent meter: medical thermoplastic elastomer (TPE) SIS40%, natural rubber 6%, medical tackifying resin 29%, medical softening agent liquid paraffin 20%, filler zinc oxide 4%, antioxidant 1% form; Wherein, by thermoplastic elastomer (TPE) SIS, natural rubber, medical softening agent liquid paraffin, antioxidant 120-130 DEG C of heated and stirred, after mix homogeneously, add medical tackifying resin, filler zinc oxide, 110-120 DEG C of heated and stirred, mix homogeneously.
3. the New Pressure-Sensitive Adhesion medium carrier for the preparation of SHUFU TIEGAO according to claim 1, it is characterized in that, described New Pressure-Sensitive Adhesion medium carrier is by weight percent meter: medical thermoplastic elastomer (TPE) SIS35%, natural rubber 6%, medical tackifying resin 20%, medical softening agent liquid paraffin 32%, filler zinc oxide 6%, antioxidant 1% form, and preparation method is with claim 2.
4. the New Pressure-Sensitive Adhesion medium carrier for the preparation of SHUFU TIEGAO according to claim 1, it is characterized in that, described New Pressure-Sensitive Adhesion medium carrier is by weight percent meter: medical thermoplastic elastomer (TPE) SIS34%, natural rubber 5%, medical tackifying resin 15%, medical softening agent liquid paraffin 38%, filler zinc oxide 7%, antioxidant 1% form, and preparation method is with claim 2.
5. claim 1 or the application of the New Pressure-Sensitive Adhesion medium carrier described in any one of 2-4 in preparation SHUFU TIEGAO, described SHUFU TIEGAO is made up of medicine and New Pressure-Sensitive Adhesion medium carrier mix homogeneously, and the percentage by weight of medicine and New Pressure-Sensitive Adhesion medium carrier is medicine 17.5-18.2%, substrate 81.8-82.5%.
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| CN201410154923.2A CN103877590B (en) | 2014-04-17 | 2014-04-17 | A kind of New Pressure-Sensitive Adhesion medium carrier for the preparation of SHUFU TIEGAO and the application in preparation SHUFU TIEGAO thereof |
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