CN106333370A - Health food prepared from selenium-enriched yeast and calcium carbonate as main raw materials and used for supplementing selenium and calcium for human body - Google Patents
Health food prepared from selenium-enriched yeast and calcium carbonate as main raw materials and used for supplementing selenium and calcium for human body Download PDFInfo
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- CN106333370A CN106333370A CN201610693819.XA CN201610693819A CN106333370A CN 106333370 A CN106333370 A CN 106333370A CN 201610693819 A CN201610693819 A CN 201610693819A CN 106333370 A CN106333370 A CN 106333370A
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- Prior art keywords
- calcium
- calcium carbonate
- enriched yeast
- selenium
- human body
- Prior art date
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Links
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title claims abstract description 94
- 239000011669 selenium Substances 0.000 title claims abstract description 93
- 240000004808 Saccharomyces cerevisiae Species 0.000 title claims abstract description 52
- 229910000019 calcium carbonate Inorganic materials 0.000 title claims abstract description 47
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 44
- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 44
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 35
- 239000011575 calcium Substances 0.000 title claims abstract description 35
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 35
- 239000002994 raw material Substances 0.000 title claims abstract description 30
- 235000013402 health food Nutrition 0.000 title claims abstract description 25
- 230000001502 supplementing effect Effects 0.000 title abstract 3
- 239000000463 material Substances 0.000 claims abstract description 23
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 90
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 40
- 229920001353 Dextrin Polymers 0.000 claims description 30
- 239000004375 Dextrin Substances 0.000 claims description 30
- 235000019425 dextrin Nutrition 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 26
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 20
- 239000008103 glucose Substances 0.000 claims description 20
- 235000019359 magnesium stearate Nutrition 0.000 claims description 20
- 239000011259 mixed solution Substances 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 13
- 229930195725 Mannitol Natural products 0.000 claims description 13
- 239000000594 mannitol Substances 0.000 claims description 13
- 235000010355 mannitol Nutrition 0.000 claims description 13
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 11
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 11
- 239000012467 final product Substances 0.000 claims description 10
- 125000005456 glyceride group Chemical group 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 10
- 239000011122 softwood Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 235000020985 whole grains Nutrition 0.000 claims description 10
- 229940022860 xylitan Drugs 0.000 claims description 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 7
- -1 xylitol acid anhydride Chemical class 0.000 claims description 7
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
- 239000000811 xylitol Substances 0.000 claims description 6
- 235000010447 xylitol Nutrition 0.000 claims description 6
- 229960002675 xylitol Drugs 0.000 claims description 6
- 238000012856 packing Methods 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 238000004090 dissolution Methods 0.000 abstract description 8
- 230000036039 immunity Effects 0.000 abstract description 6
- 230000006870 function Effects 0.000 abstract description 4
- 235000005911 diet Nutrition 0.000 abstract description 3
- 235000015097 nutrients Nutrition 0.000 abstract description 3
- 208000027219 Deficiency disease Diseases 0.000 abstract description 2
- 230000037213 diet Effects 0.000 abstract description 2
- 230000007812 deficiency Effects 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 230000007661 gastrointestinal function Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 229940091258 selenium supplement Drugs 0.000 description 34
- 230000000052 comparative effect Effects 0.000 description 18
- 230000000694 effects Effects 0.000 description 9
- 230000036541 health Effects 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- 238000009472 formulation Methods 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 210000000813 small intestine Anatomy 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 229910052793 cadmium Inorganic materials 0.000 description 2
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000001141 propulsive effect Effects 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- GAMPNQJDUFQVQO-UHFFFAOYSA-N acetic acid;phthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O GAMPNQJDUFQVQO-UHFFFAOYSA-N 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 229950006137 dexfosfoserine Drugs 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses health food prepared from selenium-enriched yeast and calcium carbonate as main raw materials and used for supplementing selenium and calcium for human body. By using selenium-enriched yeast and calcium carbonate as main raw materials and adding specific auxiliary materials, the prepared health-care tablet has a health-care function of supplementing calcium and selenium and also can enhance dissolution rate of active substances. By eating the product, inadequate diet can be supplemented, deficiency of two nutrients calcium and selenium and special deficiency disease caused by the deficiency are prevented, body immunity is raised, gastrointestinal function of human body is improved, and risk of some degenerative diseases is reduced.
Description
Technical field
The present invention relates to a kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health care food
Product, belong to field of health care food.
Background technology
Selenium, is the necessary trace element of physical activity, and selenium, mainly through gastrointestinal absorption, enters each through blood plasma delivery after absorption
Tissue, it can promote lymphocyte to produce antibody, so that haematogenic immunity globulin levels is increased, or remains normal, strengthens body pair
Antigen produces the ability of antibody, and selenium can protective tissue avoid being encroached on by noxious material, to the harmful gold in body in human body
Belong to element and play antagonism, such as selenium can reduce the absorption of cadmium, reduce cadmium accumulation in vivo, selenium can also suppress the cancer that relaxes of nickel to make
With suppressing toxicity and the teratogenesis of arsenic, preventing methylmercuric poisoning, also can prevent the toxic action of lead, fluorine, cis-platinum, silver etc..
, seldom to human body Selenium Supplement and calcium simultaneously, curative effect is also inconspicuous for current health food.
Content of the invention
It is an object of the invention to provide a kind of supplementary human body selenium made for primary raw material with Se-enriched yeast, calcium carbonate, calcium
Health food, with Se-enriched yeast and calcium carbonate as primary raw material, add specific auxiliary material, prepared health care tablet not only has
Supplement the health care of calcium and selenium moreover it is possible to improve the dissolution rate of active principle, eat this product can complementary diets not enough, prevention
The shortage of calcium and two kinds of nutrients of selenium and the special dietary deficiency disease thus being led to, are also improved body immunity, improve
Human body functions of intestines and stomach, reduces the effect of the danger of some DDs.
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, Ju Ti Pei Fang
For:
Calcium carbonate 62-63g, Se-enriched yeast 6-6.5g, CPP 1-2g, dextrin 80-120g, edible glucose
252-252.5g, citric acid 4-6g, magnesium stearate 8-12g, make 1000.
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, preparation method
For:
(1) take the dextrin of formula 10%, be dissolved in 500ml50-60 DEG C of hot water, obtain mixed solution, standby；
(2) by the dextrin of prescription surplus, calcium carbonate, Se-enriched yeast, CPP, edible glucose, put multidimensional and mix
In conjunction machine, mix 30-40 minute, mix standby；
(3) mixed material that (2) step obtains is added in trough type mixing machine, add (1) step to obtain in whipping process
The mixed solution arriving, stirs 10-20 minute, makes softwood, crosses 18 mesh, makes wet granular；
(4) wet granular making (3) step is put and 50-70 minute is dried in air drier, and temperature 60 C is so that moisture
＜ 8%, crosses 18 mesh, whole grain, obtains dry particl, standby.
(5) dry particl that (4) step obtains is added magnesium stearate, and the citric acid fine powder of size-reduced mistake 100 mesh, mixing
Uniformly, hybrid particles put compressing tablet on tablet press machine, and piece weighs 1 ± 0.05g/ piece, and packing obtains final product.
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, Ju Ti Pei Fang
For:
Calcium carbonate 62-63g, Se-enriched yeast 6-6.5g, CPP 1-2g, dextrin 80-120g, edible glucose
252-252.5g, citric acid 4-6g, magnesium stearate 8-12g, xylitan monostearate 0.5-1g, phthalic acid acetic acid are fine
The plain 0.5-1g of dimension, mannitol 0.2-0.8g, citric acid fatty glyceride 0.2-0.8g, make 1000.
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, preparation method
For:
(1) take the dextrin of formula 10%, be dissolved in 500ml50-60 DEG C of hot water, add citric acid fatty glyceride
And mannitol, obtain mixed solution, standby；
(2) by the dextrin of prescription surplus, calcium carbonate, Se-enriched yeast, CPP, edible glucose, xylitol acid anhydride
Monostearate, cellulose acetate phthalate are put in Multidimensionblender, mix 30-40 minute, mix standby；
(3) mixed material that (2) step obtains is added in trough type mixing machine, add (1) step to obtain in whipping process
The mixed solution arriving, stirs 10-20 minute, makes softwood, crosses 18 mesh, makes wet granular；
(4) wet granular making (3) step is put and 50-70 minute is dried in air drier, and temperature 60 C is so that moisture
＜ 8%, crosses 18 mesh, whole grain, obtains dry particl, standby.
(5) dry particl that (4) step obtains is added magnesium stearate, and the citric acid fine powder of size-reduced mistake 100 mesh, mixing
Uniformly, hybrid particles put compressing tablet on tablet press machine, and piece weighs 1 ± 0.05g/ piece, and packing obtains final product.
It is an advantage of the current invention that:
1. Se-enriched yeast is by inorganic selenium being converted into Organic Selenium, reduces the toxicity of inorganic selenium, improve absorption of human body and
Utilization rate, such that it is able to as a kind of safe selenium source, so it is Se-enriched yeast that the present invention selects selenium source, having instant effect, inhaling
The advantage of high income.
2., present invention adds CPP, CPP is that a class is rich in phosphoserine biologically active
Peptide, he can promote goldbeater's skin to the absorption of the mineral matters such as calcium, iron, zinc, selenium and utilization as inorganic ionic carriers.
3. the present invention with the addition of specific auxiliary material, improves the dissolution rate of active principle in product.
4. inventive formulation is the target group rnis design formulated according to Chinese NNFA, steady quality, take,
Easy to carry, beneficial to absorption, not only there is the health care of supplementary calcium and selenium, be also improved body immunity, improve human body intestines
The effect of stomach function.
Specific embodiment
Embodiment 1:
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, Ju Ti Pei Fang
For:
Calcium carbonate 62g, Se-enriched yeast 6g, CPP 1g, dextrin 80g, edible glucose 252g, citric acid 4g,
Magnesium stearate 8g, xylitan monostearate 0.5g, cellulose acetate phthalate 0.5g, mannitol 0.2g, citric acid
Fatty glyceride 0.2g, makes 1000.
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, preparation method
For:
(1) take formula 10% dextrin, be dissolved in 500ml50 DEG C of hot water, add citric acid fatty glyceride and
Mannitol, obtains mixed solution, standby；
(2) by the dextrin of prescription surplus, calcium carbonate, Se-enriched yeast, CPP, edible glucose, xylitol acid anhydride
Monostearate, cellulose acetate phthalate are put in Multidimensionblender, mix 30 minutes, mix standby；
(3) mixed material that (2) step obtains is added in trough type mixing machine, add (1) step to obtain in whipping process
The mixed solution arriving, stirs 10 minutes, makes softwood, crosses 18 mesh, makes wet granular；
(4) wet granular making (3) step is put in air drier and is dried 50 minutes, and temperature 60 C is so that moisture ＜
8%, cross 18 mesh, whole grain, obtain dry particl, standby.
(5) dry particl that (4) step obtains is added magnesium stearate, and the citric acid fine powder of size-reduced mistake 100 mesh, mixing
Uniformly, hybrid particles put compressing tablet on tablet press machine, and piece weighs 1 ± 0.05g/ piece, obtains final product.
Embodiment 2:
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, Ju Ti Pei Fang
For:
Calcium carbonate 62.5g, Se-enriched yeast 6.25g, CPP 1.5g, dextrin 100g, edible glucose
252.25g, citric acid 5g, magnesium stearate 10g, xylitan monostearate 0.7g, cellulose acetate phthalate 0.7g,
Mannitol 0.5g, citric acid fatty glyceride 0.5g, make 1000.
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, preparation method
For:
(1) take formula 10% dextrin, be dissolved in 500ml55 DEG C of hot water, add citric acid fatty glyceride and
Mannitol, obtains mixed solution, standby；
(2) by the dextrin of prescription surplus, calcium carbonate, Se-enriched yeast, CPP, edible glucose, xylitol acid anhydride
Monostearate, cellulose acetate phthalate are put in Multidimensionblender, mix 35 minutes, mix standby；
(3) mixed material that (2) step obtains is added in trough type mixing machine, add (1) step to obtain in whipping process
The mixed solution arriving, stirs 15 minutes, makes softwood, crosses 18 mesh, makes wet granular；
(4) wet granular making (3) step is put in air drier and is dried 60 minutes, and temperature 60 C is so that moisture ＜
8%, cross 18 mesh, whole grain, obtain dry particl, standby.
(5) dry particl that (4) step obtains is added magnesium stearate, and the citric acid fine powder of size-reduced mistake 100 mesh, mixing
Uniformly, hybrid particles put compressing tablet on tablet press machine, and piece weighs 1 ± 0.05g/ piece, obtains final product.
Embodiment 3:
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, Ju Ti Pei Fang
For:
Calcium carbonate 63g, Se-enriched yeast 6.5g, CPP 2g, dextrin 120g, edible glucose 252.5g, lemon
Sour 6g, magnesium stearate 12g, xylitan monostearate 1g, cellulose acetate phthalate 1g, mannitol 0.8g, lemon
Sour fatty glyceride 0.8g, makes 1000.
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, preparation method
For:
(1) take formula 10% dextrin, be dissolved in 500ml60 DEG C of hot water, add citric acid fatty glyceride and
Mannitol, obtains mixed solution, standby；
(2) by the dextrin of prescription surplus, calcium carbonate, Se-enriched yeast, CPP, edible glucose, xylitol acid anhydride
Monostearate, cellulose acetate phthalate are put in Multidimensionblender, mix 40 minutes, mix standby；
(3) mixed material that (2) step obtains is added in trough type mixing machine, add (1) step to obtain in whipping process
The mixed solution arriving, stirs 20 minutes, makes softwood, crosses 18 mesh, makes wet granular；
(4) wet granular making (3) step is put in air drier and is dried 70 minutes, and temperature 60 C is so that moisture ＜
8%, cross 18 mesh, whole grain, obtain dry particl, standby.
(5) dry particl that (4) step obtains is added magnesium stearate, and the citric acid fine powder of size-reduced mistake 100 mesh, mixing
Uniformly, hybrid particles put compressing tablet on tablet press machine, and piece weighs 1 ± 0.05g/ piece, obtains final product.
Embodiment 4:
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, Ju Ti Pei Fang
For:
Calcium carbonate 62.5g, Se-enriched yeast 6.25g, CPP 1.5g, dextrin 100g, edible glucose
252.25g, citric acid 5g, magnesium stearate 10g, make 1000.
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, preparation method
For:
(1) take the dextrin of formula 10%, be dissolved in 500ml55 DEG C of hot water, obtain mixed solution, standby；
(2) by the dextrin of prescription surplus, calcium carbonate, Se-enriched yeast, CPP, edible glucose, put multidimensional and mix
In conjunction machine, mix 35 minutes, mix standby；
(3) mixed material that (2) step obtains is added in trough type mixing machine, add (1) step to obtain in whipping process
The mixed solution arriving, stirs 15 minutes, makes softwood, crosses 18 mesh, makes wet granular；
(4) wet granular making (3) step is put in air drier and is dried 60 minutes, and temperature 60 C is so that moisture ＜
8%, cross 18 mesh, whole grain, obtain dry particl, standby.
(5) dry particl that (4) step obtains is added magnesium stearate, and the citric acid fine powder of size-reduced mistake 100 mesh, mixing
Uniformly, hybrid particles put compressing tablet on tablet press machine, and piece weighs 1 ± 0.05g/ piece, and packing obtains final product.
Comparative example 1:
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, Ju Ti Pei Fang
For:
Calcium carbonate 60g, Se-enriched yeast 7g, CPP 0.5g, dextrin 130g, edible glucose 240g, citric acid
8g, magnesium stearate 5g, xylitan monostearate 2g, cellulose acetate phthalate 0.3g, mannitol 1g, citric acid fat
Fatty acid glyceride 0.1g, makes 1000.
Remaining is with embodiment 1.
Comparative example 2:
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, Ju Ti Pei Fang
For:
Calcium carbonate 62.5g, Se-enriched yeast 6.25g, CPP 1.5g, dextrin 100g, edible glucose
252.25g, citric acid 5g, magnesium stearate 10g, xylitan monostearate 0.7g, mannitol 0.5g, make 1000.
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, preparation method
For:
(1) take the dextrin of formula 10%, be dissolved in 500ml55 DEG C of hot water, in addition and mannitol, obtain mixed solution,
Standby；
(2) by the dextrin of prescription surplus, calcium carbonate, Se-enriched yeast, CPP, edible glucose, xylitol acid anhydride
Monostearate is put in Multidimensionblender, mixes 35 minutes, mixes standby；
(3) mixed material that (2) step obtains is added in trough type mixing machine, add (1) step to obtain in whipping process
The mixed solution arriving, stirs 15 minutes, makes softwood, crosses 18 mesh, makes wet granular；
(4) wet granular making (3) step is put in air drier and is dried 60 minutes, and temperature 60 C is so that moisture ＜
8%, cross 18 mesh, whole grain, obtain dry particl, standby.
(5) dry particl that (4) step obtains is added magnesium stearate, and the citric acid fine powder of size-reduced mistake 100 mesh, mixing
Uniformly, hybrid particles put compressing tablet on tablet press machine, and piece weighs 1 ± 0.05g/ piece, obtains final product.
Comparative example 3:
A kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, preparation method
For:
(1) take formula 10% dextrin, be dissolved in 500ml60 DEG C of hot water, add xylitan monostearate and
Mannitol, obtains mixed solution, standby；
(2) by the dextrin of prescription surplus, calcium carbonate, Se-enriched yeast, CPP, edible glucose, citric acid fat
Fatty acid glyceride, cellulose acetate phthalate are put in Multidimensionblender, mix 40 minutes, mix standby；
(3) mixed material that (2) step obtains is added in trough type mixing machine, add (1) step to obtain in whipping process
The mixed solution arriving, stirs 20 minutes, makes softwood, crosses 18 mesh, makes wet granular；
(4) wet granular making (3) step is put in air drier and is dried 70 minutes, and temperature 60 C is so that moisture ＜
8%, cross 18 mesh, whole grain, obtain dry particl, standby.
(5) dry particl that (4) step obtains is added magnesium stearate, and the citric acid fine powder of size-reduced mistake 100 mesh, mixing
Uniformly, hybrid particles put compressing tablet on tablet press machine, and piece weighs 1 ± 0.05g/ piece, obtains final product.
Remaining is with embodiment 3.
1. investigate embodiment of the present invention 1-4 and comparative example 1-3 is obtained dissolution rate and the disintegration time limited of product, result such as following table
Shown:
The dissolution rate of table 1 product of the present invention and disintegration time limited
| Group | Disintegration time limited (s) | Dissolution rate (%) |
| Embodiment 1 | 283 | 97.6 |
| Embodiment 2 | 269 | 98.8 |
| Embodiment 3 | 275 | 98.1 |
| Embodiment 4 | 301 | 92.7 |
| Comparative example 1 | 320 | 89.3 |
| Comparative example 2 | 357 | 84.9 |
| Comparative example 3 | 362 | 85.5 |
From upper table data can be seen that the health care tablet (embodiment 1-4) that the present invention is obtained disintegration time limited is very fast, dissolution
Spend higher hence it is evident that (preparing work better than comparative example 1 (formulation ratio is different), comparative example 2 (few several auxiliary materials in formula), comparative example 3
In skill, the order of addition of auxiliary material is different), especially with the best results of embodiment 2 it is seen that the present invention utilizes Se-enriched yeast and carbon
Sour calcium is primary raw material, adds specific several auxiliary materials, using certain proportioning and preparation technology, acts synergistically, prepared guarantor
The disintegration time limited of strong tablet is very fast, and dissolution rate is higher, and bioavailability height is so that people's physical efficiency faster and better absorbs working substance
Matter.
2. the effect to enhance immunity for the present invention:
Take 80 mouse, body weight 18-24g, be randomly divided into 8 groups, every group 10, take 7 groups, press embodiment 1-4 and right respectively
With the daily gavage of 0.5g/100g mouse, 1 group of control group gives equivalent distilled water to the product that ratio 1-3 is obtained, once a day, even
Continue and give 30 days, in the 25th day lumbar injection 2%srbc, after immune 5 days, dislocation is put to death, and takes spleen, 200 mesh sieve net filtrations, uses
Hanks liquid is washed 3 times, and each 100or/min is centrifuged 10min, and cell is suspended in 5mlrpm1640 nutrient solution.Top layer is cultivated
Base heating for dissolving, 45 DEG C of water bath heat preservations, mix with 2 times of concentration hanks liquid of equivalent, dispense small test tube, often manage o.5ml, add 50 μ
L110%srbc, 20 μ l splenocyte suspensions, mix, reviewing, cultivate 1 hour in CO2gas incubator, add and use sa buffer solution
The complement (1:10) of dilution, continues culture 1 hour, counts hemolysis plaque number, and result is as shown in table 2.
The impact to mouse antibodies cellulation for table 2 present invention (N=10)
As known from Table 2, the antibody tormation that the health care tablet (embodiment 1-4) that the present invention is obtained can significantly improve mouse is thin
Born of the same parents, effect is substantially better than comparative example 1 (formulation ratio is different), comparative example 2 (few several auxiliary materials in formula), comparative example 3 (preparation work
In skill, the order of addition of auxiliary material is different), especially with the best results of embodiment 2 it is seen that the present invention utilizes Se-enriched yeast and carbon
Sour calcium is primary raw material, adds specific several auxiliary materials, using certain proportioning and preparation technology, acts synergistically, prepared guarantor
Strong tablet is improved the effect of antibody-producting cell, can improve body immunity.
3. the present invention acts on to improving functions of intestines and stomach
Take mouse 80, body weight 18-24g, male and female dual-purpose, be randomly divided into 8 groups, every group 10, be followed successively by blank control group,
Embodiment 1-4 group (daily dosage 0.5g/100g), comparative example 1-3 group (daily dosage 0.5g/100g)；Blank control group gives
Equal-volume distilled water, embodiment 1-4 group and comparative example 1-3 group successive administration 5d；Last dose next day (6d), mouse freely drinks
Water, fasting 24h, be administered respectively by each dosage group or distilled water 30min after, each dosage group ig gives 0.2ml india ink, interval
20min, de- cervical vertebra is put to death and is cut open the belly immediately, and alimentary canal is completely extracted from pylorus to rectum end, is not added with drawing, tiling digestion
Road, surveys charcoal end forward position to pylorus distance, it is Intestinal propulsive rate that this length accounts for small intestine total length percentage, and result is as shown in table 3.
Impact that table 3 present invention advances to mouse small intestine (N=10)
As known from Table 3, the health care tablet (embodiment 1-4) that the present invention is obtained can significantly improve the small intestine push of mouse
Rate, effect is substantially better than comparative example 1 (formulation ratio is different), comparative example 2 (few several auxiliary materials in formula), comparative example 3 (preparation work
In skill, the order of addition of auxiliary material is different), especially with the best results of embodiment 2 it is seen that the present invention utilizes Se-enriched yeast and carbon
Sour calcium is primary raw material, adds specific several auxiliary materials, using certain proportioning and preparation technology, acts synergistically, prepared guarantor
Strong tablet can have positive effect with Intestinal propulsive rate to improving functions of intestines and stomach effect.
Claims (4)
1. a kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, it is characterized by:
Ju Ti Pei Fang is:
Calcium carbonate 62-63g, Se-enriched yeast 6-6.5g, CPP 1-2g, dextrin 80-120g, edible glucose 252-
252.5g, citric acid 4-6g, magnesium stearate 8-12g, make 1000.
2. as claimed in claim 1 a kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium guarantor
Health food, it is characterized by: preparation method is:
(1) take the dextrin of formula 10%, be dissolved in 500ml50-60 DEG C of hot water, obtain mixed solution, standby；
(2) by the dextrin of prescription surplus, calcium carbonate, Se-enriched yeast, CPP, edible glucose, put Multidimensionblender
In, mix 30-40 minute, mix standby；
(3) mixed material that (2) step obtains is added in trough type mixing machine, add (1) step to obtain in whipping process
Mixed solution, stirs 10-20 minute, makes softwood, crosses 18 mesh, makes wet granular；
(4) wet granular making (3) step is put and 50-70 minute is dried in air drier, and temperature 60 C is so that moisture ＜
8%, cross 18 mesh, whole grain, obtain dry particl, standby.
(5) dry particl that (4) step obtains is added magnesium stearate, and the citric acid fine powder of size-reduced mistake 100 mesh, mixing is all
Even, hybrid particles put compressing tablet on tablet press machine, and piece weighs 1 ± 0.05g/ piece, and packing obtains final product.
3. a kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium health food, it is characterized by:
Ju Ti Pei Fang is:
Calcium carbonate 62-63g, Se-enriched yeast 6-6.5g, CPP 1-2g, dextrin 80-120g, edible glucose 252-
252.5g, citric acid 4-6g, magnesium stearate 8-12g, xylitan monostearate 0.5-1g, cellulose acetate phthalate
0.5-1g, mannitol 0.2-0.8g, citric acid fatty glyceride 0.2-0.8g, make 1000.
4. as claimed in claim 3 a kind of with Se-enriched yeast, supplementary human body selenium that calcium carbonate is made for primary raw material, calcium guarantor
Health food, it is characterized by: preparation method is:
(1) take the dextrin of formula 10%, be dissolved in 500ml50-60 DEG C of hot water, add citric acid fatty glyceride and sweet
Dew alcohol, obtains mixed solution, standby；
(2) will be hard to the dextrin of prescription surplus, calcium carbonate, Se-enriched yeast, CPP, edible glucose, xylitol acid anhydride list
Resin acid ester, cellulose acetate phthalate are put in Multidimensionblender, mix 30-40 minute, mix standby；
(3) mixed material that (2) step obtains is added in trough type mixing machine, add (1) step to obtain in whipping process
Mixed solution, stirs 10-20 minute, makes softwood, crosses 18 mesh, makes wet granular；
(4) wet granular making (3) step is put and 50-70 minute is dried in air drier, and temperature 60 C is so that moisture ＜
8%, cross 18 mesh, whole grain, obtain dry particl, standby.
(5) dry particl that (4) step obtains is added magnesium stearate, and the citric acid fine powder of size-reduced mistake 100 mesh, mixing is all
Even, hybrid particles put compressing tablet on tablet press machine, and piece weighs 1 ± 0.05g/ piece, obtains final product.
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| CN108967800A (en) * | 2018-08-13 | 2018-12-11 | 蔡艳霞 | A kind of functional solid beverage and preparation method thereof |
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