CN106318847A - Nucleic acid extraction equipment capable of eccentric oscillation - Google Patents
Nucleic acid extraction equipment capable of eccentric oscillation Download PDFInfo
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- CN106318847A CN106318847A CN201610708053.8A CN201610708053A CN106318847A CN 106318847 A CN106318847 A CN 106318847A CN 201610708053 A CN201610708053 A CN 201610708053A CN 106318847 A CN106318847 A CN 106318847A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
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Abstract
The invention relates to nucleic acid extraction equipment capable of eccentric oscillation, which comprises a base, a test tube rack, a magnetic rod sleeve rack and a magnetic rod rack arranged on the base, a test tube rack driving mechanism, a magnetic rod sleeve driving mechanism and a magnetic rod diving mechanism, wherein the test tube rack driving mechanism, the magnetic rod sleeve driving mechanism and the magnetic rod driving mechanism are used for respectively driving the test tube rack, the magnetic sleeve rack and the magnetic rod rack to act independently. The nucleic acid extraction equipment is characterized in that an output shaft of the test tube rack driving mechanism is an eccentric shaft, wherein the eccentric shaft drives the test tube rack to do eccentric rotation; power output ends are arranged on the magnetic rod sleeve driving mechanism and the magnetic rod driving mechanism respectively; and the power output ends respectively drive the magnetic rod sleeve rack and the magnetic rod rack to reciprocate in a direction vertical to the rotation surface of the test tube rack. The eccentric oscillation nucleic acid extraction equipment has the following effects: for the nucleic acid extraction work with a relatively large sample volume, an eccentric driving mechanism is adopted to drive the test tube rack to do circumferential rotation or curved rotation or linear/nonlinear back-and-forth oscillation in the circumferential direction or spatial direction, the nucleic acid and magnetic beads can be sufficiently mixed, and the extraction rate and extraction efficiency can be improved.
Description
Technical field
The present invention relates to a kind of nucleic acid extraction instrument, particularly relate to the nucleic acid extraction instrument of a kind of eccentric swing.
Background technology
Extracting nucleic-acid manipulation at paramagnetic particle method, magnetic bead is the most abundant with the mixing of free nucleic acid, and bar magnet absorption magnetic bead is the most complete,
Most important to nucleic acid extraction effect, particularly magnetic bead mixing operation and the magnetic bead of large volume sample adsorbs, particularly important.For
For the nucleic acid extraction work of conventional low capacity, when extracting nucleic acid, pumped by bar magnet, bar magnet overlaps gyration,
And by the imbibition of pipettor, draining mode, making magnetic bead mix with free nucleic acid, magnetic bead absorption nucleic acid, then bar magnet is by magnetic
Pearl absorption overlaps outer wall at bar magnet, completes a step of nucleic acid extraction work.
Work for extracting sample volume big is said, when extracting nucleic acid, after adding lysate, buffer and magnetic bead liquid, always
Liquid volume bigger, need, by the sample tube of large volume, to be difficult to make large volume sample liquid with magnetic bead mixing fully, with general
Logical nucleic acid extracting instrument is difficult to extract completely the work of nucleic acid: extraction nucleic acid is thorough or needs increase extraction time to carry out not
Repeat mixing disconnectedly, extract work, have influence on extraction ratio and extraction efficiency.
Summary of the invention
It is an object of the invention to solve the problems referred to above of prior art existence and provide the nucleic acid of a kind of eccentric swing to carry
Taking equipment, particularly with the nucleic acid extraction work that sample volume is bigger, uses test tube rack drive mechanism and be eccentric drive mechanism,
Drive test tube rack to do in-plane or the circular-rotation of direction in space or curve mode rotates or linear/non-linear comes and goes pendulum
Dynamic, and described bar magnet stock and bar magnet frame are perpendicular to the direction back and forth movement of described test tube rack plane of rotation, including being perpendicular to examination
Pipe inside, back and forth movement outward, also include being perpendicular to test tube inside, outward while back and forth movement, in the axis of test tube being
Mandrel rotates, it is possible to make nucleic acid and magnetic bead be sufficiently mixed, it is possible to increase extraction ratio and extraction efficiency.
The above-mentioned technical purpose of the present invention mainly solves by the following technical programs: the nucleic acid extraction of eccentric swing sets
Standby, including pedestal, the test tube rack being arranged on pedestal, bar magnet stock and bar magnet frame, drive test tube rack, magnetosheath frame and bar magnet respectively
The test tube rack drive mechanism of frame self contained function, bar magnet set drive mechanism and bar magnet drive mechanism, it is characterised in that: described test tube rack
The output shaft of drive mechanism is eccentric shaft, and described eccentric shaft drives described test tube rack to do eccentric rotary, described bar magnet set driving machine
Being respectively provided with clutch end on structure and bar magnet drive mechanism, described clutch end drives described bar magnet stock and bar magnet respectively
Frame is perpendicular to the direction back and forth movement of described test tube rack plane of rotation.For the nucleic acid extraction work that sample volume is bigger, use
Test tube rack drive mechanism and be eccentric drive mechanism, drives test tube rack to do in-plane or the circular-rotation of direction in space or curve
Mode rotates or linear/non-linear reciprocating swing, and described bar magnet stock and bar magnet frame are perpendicular to described test tube rack and rotate
The direction back and forth movement in face, including be perpendicular to test tube inside, back and forth movement outward, also include being perpendicular to test tube inside, the most past
While returning motion, centered by the axis of test tube, axle rotates, it is possible to make nucleic acid (and the lysate of large volume sample
Deng) and magnetic bead be sufficiently mixed, magnetic bead fully adsorbs nucleic acid, it is possible to increase extraction ratio and extraction efficiency.
Additionally, the technical program is equally applicable to the operation of the nucleic acid extraction processes such as follow-up washing and eluting.
As improving further and supplementing technique scheme, the present invention uses following technical measures: described test tube
Frame drive mechanism includes the motor being arranged on pedestal, by described motor-driven eccentric stiffener, and inclined on described eccentric stiffener
The outfan of mandrel connects described test tube rack, drives described test tube rack to do eccentric rotary.Eccentric stiffener drives test tube rack action, sample
This pipe mixes for magnetic bead with test tube rack synchronization action, high speed motion, and low speed action is used for adsorbing magnetic bead.
Described eccentric stiffener includes the output wheel being arranged on motor output shaft, output wheel the driving wheel driven is described
Driving wheel drives eccentric shaft turns.
Wherein, driving driving wheel action about output wheel, at least include following two scheme, any scheme is all can
To implement:
The first scheme: described output wheel is gear, drives described driving wheel by gear teeth wheels；
First scheme: described output wheel is belt wheel, drives described driving wheel by conveyer belt.Wherein, belt wheel is belt or chain
Bar.Coordinate with belt for output belt pulley and driving belt pulley；With chain interoperation for output gear and drive gear.
Described driving wheel is provided with balance weight, is used for keeping described driving wheel smooth rotation.Balance weight is used for balancing bias
The eccentric amount of unbalance of mechanism, test tube rack steadily swings, and meanwhile, driving wheel will not be followed Spin tubes frame action and produce bias
Vibration.
Described eccentric shaft includes drive portion, is positioned at the lower fixed part of drive division both sides and upper drive division, described lower fixed part
Being fixed on described pedestal by bearing, described upper drive division connects one by bearing and moves gripper shoe, and described dynamic gripper shoe sets
Put described test tube rack.Eccentric shaft is structure as a whole, and lower fixed part and upper drive division, respectively by bearings, make eccentric shaft spacing
Pedestal rotates.Test tube rack is connected with eccentric stiffener by dynamic gripper shoe, it is possible to make test tube rack overall structure simplify, it is to avoid
There is the substrate of high intensity.Due to the size of the test tube position on test tube rack according to test tube depending on, therefore there is different size
Test tube rack, after using the technical program, the overall structure of test tube rack is relatively reasonable, is convenient for changing, and is also convenient for reducing cost.
Arranging a retainer ring bottom described dynamic gripper shoe, described upper drive division is spacing in described retainer ring, described on drive
Bearing in dynamic portion is a clutch shaft bearing, and the bearing on described lower fixed part is two spaced bearings, respectively the
Two bearings and the 3rd bearing.Use scheme the racking gripper shoe of three bearings so that dynamic gripper shoe only eccentric action, do not produce
Raw revolution action.
Arranging some fixing pillars on described pedestal, described fixing pillar is that encirclement mode is distributed, on described fixing pillar
Arranging outer polarization ring, arrange interior polarization ring in described outer polarization ring, described interior polarization ring is fixed on described fixing by connecting plate
On ring, described interior polarization ring is fixed on outer polarization ring by the first spring leaf, and described outer polarization ring is solid by the second spring leaf
It is scheduled on described fixing pillar.
Also include that electronic control system, described electronic control system are driven with described motor, bar magnet drive mechanism and bar magnet set
Motivation structure signal connects, for controlling described test tube rack, magnetosheath frame and bar magnet frame action respectively.Accurately controlled by electronic control system
Make each drive mechanism precise movement, finally improve the degree of accuracy of instrument for extracting nucleic acid work.When being embodied as, on motor or
Arranging motor speed sensor on pedestal, speed probe is for detecting the rotating speed of described motor, and rotating speed is sent to electronics
Control system, electronic control system sends instruction control motor according to rotary speed information and appropriately works.
Also include attemperating unit, invisible spectro in temperature control and/or test tubes frameLiquidTemperature.Make invisible spectro liquid
Temperature is appropriate problem, meets the requirement extracted, it is to avoid temperature of liquid is too high or too low, is conducive to improving extraction efficiency and carrying
Take rate.
The invention have the benefit that 1, for the nucleic acid extraction work that sample volume is bigger, use test tube rack
Drive mechanism and be eccentric drive mechanism, drives test tube rack to do in-plane or the circular-rotation of direction in space or curve mode turns
Move or linear/non-linear reciprocating swing, and described bar magnet stock and bar magnet frame are perpendicular to the side of described test tube rack plane of rotation
To back and forth movement, including be perpendicular to test tube inside, back and forth movement outward, also include being perpendicular to test tube inside, back and forth movement outward
While, centered by the axis of test tube, axle rotates, it is possible to make nucleic acid and magnetic bead be sufficiently mixed, it is possible to increase extraction ratio
And extraction efficiency.2, balance weight is set in test tube rack drive mechanism for balancing the eccentric amount of unbalance of eccentric stiffener, test tube rack
Steadily swinging, meanwhile, driving wheel will not be followed Spin tubes frame action and produce eccentric vibrating.3, eccentric shaft uses three bearings
Scheme racking gripper shoe so that dynamic gripper shoe only eccentric action, do not produce revolution action.4, by electronic control system essence
Really control each drive mechanism precise movement, finally improve the degree of accuracy of instrument for extracting nucleic acid work, when being embodied as, on motor
Or arranging motor speed sensor on pedestal, speed probe is for detecting the rotating speed of described motor, and is sent to by rotating speed
Electronic control system, electronic control system sends instruction control motor according to rotary speed information and appropriately works.5. attemperating unit is set,
Invisible spectro temperature of liquid in temperature control and/or test tubes frame, making invisible spectro temperature of liquid is appropriate problem, meets and carries
The requirement taken, it is to avoid temperature of liquid is too high or too low, is conducive to improving extraction efficiency and extraction ratio.
Accompanying drawing explanation
Fig. 1 is the structural representation of the compositions such as each drive mechanism in the present invention, test tube rack, bar magnet frame, bar magnet stock.
Fig. 2 is the sectional structure schematic diagram of test tube rack drive mechanism in the present invention.
Fig. 3 is the structural representation that in the present invention, test tube rack drive mechanism coordinates polarization ring.
Detailed description of the invention
Below by embodiment, and combine accompanying drawing, technical scheme is described in further detail.
Embodiment: the nucleic acid extraction instrument of eccentric swing, including pedestal, the test tube rack being arranged on pedestal, bar magnet stock
With bar magnet frame, drive test tube rack, magnetosheath frame and the test tube rack drive mechanism of bar magnet frame self contained function, bar magnet set drive mechanism respectively
With bar magnet drive mechanism, it is characterised in that: the output shaft of described test tube rack drive mechanism is eccentric shaft, and described eccentric shaft drives institute
State test tube rack and do eccentric rotary, described bar magnet set drive mechanism and bar magnet drive mechanism are respectively provided with clutch end, described
Clutch end drives described bar magnet stock and bar magnet frame to be perpendicular to the direction back and forth movement of described test tube rack plane of rotation respectively.
For the nucleic acid extraction work that sample volume is bigger, use test tube rack drive mechanism and be eccentric drive mechanism, drive test tube rack
Do in-plane or the circular-rotation of direction in space or curve mode rotates or linear/non-linear reciprocating swing, and described magnetic
Rod stock and bar magnet frame are perpendicular to the direction back and forth movement of described test tube rack plane of rotation, including being perpendicular to test tube inside, outward
Back and forth movement, also include being perpendicular to test tube inside, outward while back and forth movement, centered by the axis of test tube, axle does rotation fortune
It is dynamic, it is possible to making the nucleic acid (and lysate etc.) of large volume sample and magnetic bead be sufficiently mixed, magnetic bead fully adsorbs nucleic acid, it is possible to increase
Extraction ratio and extraction efficiency.
Additionally, the technical program is equally applicable to the operation of the nucleic acid extraction processes such as follow-up washing and eluting.
As improving further and supplementing technique scheme, the present invention uses following technical measures: described test tube
Frame drive mechanism includes the motor being arranged on pedestal, by described motor-driven eccentric stiffener, and inclined on described eccentric stiffener
The outfan of mandrel connects described test tube rack, drives described test tube rack to do eccentric rotary.Eccentric stiffener drives test tube rack action, sample
This pipe mixes for magnetic bead with test tube rack synchronization action, high speed motion, and low speed action is used for adsorbing magnetic bead.
Described eccentric stiffener includes the output wheel being arranged on motor output shaft, output wheel the driving wheel driven is described
Driving wheel drives eccentric shaft turns.
Wherein, driving driving wheel action about output wheel, at least include following two scheme, any scheme is all can
To implement:
The first scheme: described output wheel is gear, drives described driving wheel by gear teeth wheels；
First scheme: described output wheel is belt wheel, drives described driving wheel by conveyer belt.Wherein, belt wheel is belt or chain
Bar.Coordinate with belt for output belt pulley and driving belt pulley；With chain interoperation for output gear and drive gear.
Described driving wheel is provided with balance weight, is used for keeping described driving wheel smooth rotation.Balance weight is used for balancing bias
The eccentric amount of unbalance of mechanism, test tube rack steadily swings, and meanwhile, driving wheel will not be followed Spin tubes frame action and produce bias
Vibration.
Described eccentric shaft includes drive portion, is positioned at the lower fixed part of drive division both sides and upper drive division, described lower fixed part
Being fixed on described pedestal by bearing, described upper drive division connects one by bearing and moves gripper shoe, and described dynamic gripper shoe sets
Put described test tube rack.Eccentric shaft is structure as a whole, and lower fixed part and upper drive division, respectively by bearings, make eccentric shaft spacing
Pedestal rotates.Test tube rack is connected with eccentric stiffener by dynamic gripper shoe, it is possible to make test tube rack overall structure simplify, it is to avoid
There is the substrate of high intensity.Due to the size of the test tube position on test tube rack according to test tube depending on, therefore there is different size
Test tube rack, after using the technical program, the overall structure of test tube rack is relatively reasonable, is convenient for changing, and is also convenient for reducing cost.
Arranging a retainer ring bottom described dynamic gripper shoe, described upper drive division is spacing in described retainer ring, described on drive
Bearing in dynamic portion is a clutch shaft bearing, and the bearing on described lower fixed part is two spaced bearings, respectively the
Two bearings and the 3rd bearing.Use scheme the racking gripper shoe of three bearings so that dynamic gripper shoe only eccentric action, do not produce
Raw revolution action.
Arranging some fixing pillars on described pedestal, described fixing pillar is that encirclement mode is distributed, on described fixing pillar
Arranging outer polarization ring, arrange interior polarization ring in described outer polarization ring, described interior polarization ring is fixed on described fixing by connecting plate
On ring, described interior polarization ring is fixed on outer polarization ring by the first spring leaf, and described outer polarization ring is solid by the second spring leaf
It is scheduled on described fixing pillar.
Also include that electronic control system, described electronic control system are driven with described motor, bar magnet drive mechanism and bar magnet set
Motivation structure signal connects, for controlling described test tube rack, magnetosheath frame and bar magnet frame action respectively.Accurately controlled by electronic control system
Make each drive mechanism precise movement, finally improve the degree of accuracy of instrument for extracting nucleic acid work.When being embodied as, on motor or
Arranging motor speed sensor on pedestal, speed probe is for detecting the rotating speed of described motor, and rotating speed is sent to electronics
Control system, electronic control system sends instruction control motor according to rotary speed information and appropriately works.
Also include attemperating unit, invisible spectro in temperature control and/or test tubes frameLiquidTemperature.Make invisible spectro liquid
Temperature is appropriate problem, meets the requirement extracted, it is to avoid temperature of liquid is too high or too low, is conducive to improving extraction efficiency and carrying
Take rate.
Now technique scheme is done and illustrates in detail:
As it is shown in figure 1, eight sample tube 1 on instrument for extracting nucleic acid, sample tube 1 is installed in test tube rack 2, and test tube rack 2 is fixed on dynamic
In gripper shoe 11, follow eccentric drive mechanism 13 eccentric action.
Bar magnet set 3 is installed on bar magnet stock 4, follows bar magnet set drive mechanism 8 and carries out action (parallel test tube axis direction
Move bottom test tube or move away from test tube direction, or rotation with test tube axis as axle while movement), it extend into
Time in sample tube 1, can arrive bottom sample tube 1.
Bar magnet 5 is installed on bar magnet frame 6, follow bar magnet drive mechanism 7 carry out action (include parallel bar magnet overlap axis direction
Move bottom test tube or move away from test tube direction, or overlap the axis rotation as axle with bar magnet while movement), bar magnet
5 stretch into bar magnet when overlapping 3, and to bottom bar magnet set 3, bar magnet set 3 can follow associating longitudinal moving mechanism 9(together with bar magnet 5 can be together
Time drive bar magnet stock 4 action together with bar magnet frame 6) (parallel test tube axis direction is moved or away from examination bottom test tube in action
Pipe direction is moved, or rotation with test tube axis as axle while movement).Reagent set 10 is installed in fixed plate 12.
As shown in Figures 2 and 3, the driving motor 23 on eccentric drive mechanism 13 is positioned pedestal 14 by fixed support 30
On, motor 23 direct drive installation output pulley 15 on its motor shaft, drive driving pulley 17, drive belt by belt 16
Wheel 17 drive eccentric shaft 25 associated with it, the lower fixed part on eccentric shaft 25 is in the fixing seat 29 being arranged on pedestal
Hole, and supported by the second bearing 24 and the 3rd bearing 26, fixing seat 29 is positioned on pedestal 14；The upper drive division of eccentric shaft 25 with
Being provided with clutch shaft bearing 27 between retainer ring 21 endoporus, in retainer ring 21, plane is fixing with dynamic gripper shoe 11 is connected, two row's sample tube
Frame 2 is then fixed in dynamic gripper shoe 11；Retainer ring 21 outer ring is connected by connecting plate with interior polarization ring 18, and interior polarization ring 18 passes through
Spring leaf 22 is connected with outer polarization ring, and outer polarization ring 19 is connected with fixing pillar 20 by spring leaf 22, and balance weight 28 is used for putting down
The amount of unbalance of weighing apparatus eccentric drive mechanism；Thus realize being driven eight sample tube 1 action in dynamic gripper shoe 11 by motor 23, and
Eccentric shaft will not be followed rotate and produce eccentric vibrating.
The eccentric diameter of eccentric shaft, according to sample tube diameter, the bar magnet set correlative factor such as diameter and cumulative volume by design
Calculating determines.
Bar magnet set 3 and the translational speed of bar magnet 5, amplitude and position, all can be by electronic-controlled installation according to presetting
Control.
During large volume sample nucleic acid extracts, driven the action of sample tube 1 by eccentric drive mechanism 13, it is achieved big
Volume samples, lysate mix with magnetic bead, and magnetic bead absorption.
By bar magnet set 3 and the action of bar magnet 5, the nucleic acid extraction such as washing, eluting can be completed at the Kong Weizhong of reagent set 10
Operating procedure.
The large volume that the large volume sample that the present invention relates to refers in sample at more than 2ml, maximum process volume be 5ml with
On.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention.In the above-described embodiments,
The present invention can have various modifications and variations.All within the spirit and principles in the present invention, any amendment of being made, equivalent are replaced
Change, improvement etc., should be included within the scope of the present invention.
Claims (10)
1. the nucleic acid extraction instrument of eccentric swing, including pedestal, the test tube rack being arranged on pedestal, bar magnet stock and bar magnet frame,
Test tube rack, magnetosheath frame and the test tube rack drive mechanism of bar magnet frame self contained function, bar magnet set drive mechanism and bar magnet is driven to drive respectively
Motivation structure, it is characterised in that: the output shaft of described test tube rack drive mechanism is eccentric shaft, and described eccentric shaft drives described test tube rack
Doing eccentric rotary, described bar magnet set drive mechanism and bar magnet drive mechanism are respectively provided with clutch end, described power exports
End drives described bar magnet stock and bar magnet frame to be perpendicular to the direction back and forth movement of described test tube rack plane of rotation respectively.
The nucleic acid extraction instrument of eccentric swing the most according to claim 1, it is characterised in that: described test tube rack drive mechanism
Including the motor being arranged on pedestal, by described motor-driven eccentric stiffener, the output of the eccentric shaft on described eccentric stiffener
End connects described test tube rack, drives described test tube rack to do eccentric rotary.
The nucleic acid extraction instrument of eccentric swing the most according to claim 2, it is characterised in that: described eccentric stiffener includes setting
Put the output wheel on motor output shaft, output wheel the driving wheel driven, described driving wheel drives eccentric shaft turns.
The nucleic acid extraction instrument of eccentric swing the most according to claim 3, it is characterised in that:
Described output wheel is gear, drives described driving wheel by gear teeth wheels；
Or described output wheel is belt wheel, drives described driving wheel by conveyer belt.
The nucleic acid extraction instrument of eccentric swing the most according to claim 4, it is characterised in that: described driving wheel is provided with flat
Weighing apparatus block, is used for keeping described driving wheel smooth rotation.
The nucleic acid extraction instrument of eccentric swing the most according to claim 5, it is characterised in that: described eccentric shaft includes driving
Portion, is positioned at the lower fixed part of drive division both sides and upper drive division, and described lower fixed part is fixed on described pedestal by bearing, institute
State drive division and move gripper shoe by bearing connection one, described dynamic gripper shoe arranges described test tube rack.
The nucleic acid extraction instrument of eccentric swing the most according to claim 6, it is characterised in that: set bottom described dynamic gripper shoe
Putting a retainer ring, described upper drive division is spacing in described retainer ring, and the bearing on described upper drive division is a clutch shaft bearing,
Bearing on described lower fixed part is two spaced bearings, the respectively second bearing and the 3rd bearing.
The nucleic acid extraction instrument of eccentric swing the most according to claim 7, it is characterised in that: arrange some on described pedestal
Fixing pillar, described fixing pillar is that encirclement mode is distributed, and described fixing pillar arranges outer polarization ring, in described outer polarization ring
Arranging interior polarization ring, described interior polarization ring is fixed in described retainer ring by connecting plate, and described interior polarization ring passes through the first bullet
Reed is fixed on outer polarization ring, and described outer polarization ring is fixed on described fixing pillar by the second spring leaf.
9. according to the nucleic acid extraction instrument of the eccentric swing described in any one in claim 1-8, it is characterised in that: also include
Electronic control system, described electronic control system is connected with described motor, bar magnet drive mechanism and bar magnet set drive mechanism signal,
For controlling described test tube rack, magnetosheath frame and bar magnet frame action respectively.
10. according to the nucleic acid extraction instrument of the eccentric swing described in any one in claim 1-8, it is characterised in that: also wrap
Include attemperating unit, invisible spectro temperature of liquid in temperature control and/or test tubes frame.
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| CN201610708053.8A CN106318847A (en) | 2016-08-22 | 2016-08-22 | Nucleic acid extraction equipment capable of eccentric oscillation |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106520547A (en) * | 2017-01-13 | 2017-03-22 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Nucleic acid extraction equipment |
| CN110777143A (en) * | 2019-11-29 | 2020-02-11 | 杭州博日科技有限公司 | Rotation and oscillation combined uniform mixing nucleic acid extraction and purification equipment and method |
| CN110819627A (en) * | 2019-11-29 | 2020-02-21 | 杭州博日科技有限公司 | Multi-column single tube consumable and use method thereof in nucleic acid extraction and purification by magnetic rod method |
| CN110923124A (en) * | 2020-02-17 | 2020-03-27 | 中国农业科学院蔬菜花卉研究所 | Instrument for extracting and purifying nucleic acid by magnetic bead method |
| CN111273032A (en) * | 2020-03-05 | 2020-06-12 | 北京新艾进生物科技有限公司 | Device and method for uniformly mixing and enriching magnetic beads in detection of anti-drug antibodies |
| CN112391285A (en) * | 2020-12-26 | 2021-02-23 | 宋慧香 | Continuous nucleic acid detection reactor and use method thereof |
| CN112844151A (en) * | 2020-11-26 | 2021-05-28 | 珠海启奥生物技术有限公司 | Nucleic acid extraction equipment and mixing device based on eccentric oscillation |
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