CN106310480B - Nose cup is used in a kind of sleep - Google Patents

Nose cup is used in a kind of sleep Download PDF

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Publication number
CN106310480B
CN106310480B CN201610825578.XA CN201610825578A CN106310480B CN 106310480 B CN106310480 B CN 106310480B CN 201610825578 A CN201610825578 A CN 201610825578A CN 106310480 B CN106310480 B CN 106310480B
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Prior art keywords
parts
bracket
sleep
appendix
rhinarium
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Expired - Fee Related
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CN201610825578.XA
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CN106310480A (en
Inventor
郑浩
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Chengdu Cedisen Biological Technology Co Ltd
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Chengdu Cedisen Biological Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003Accessories therefor, e.g. sensors, vibrators, negative pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • A61M16/0605Means for improving the adaptation of the mask to the patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • A61M16/0605Means for improving the adaptation of the mask to the patient
    • A61M16/0627Means for improving the adaptation of the mask to the patient with sealing means on a part of the body other than the face, e.g. helmets, hoods or domes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D46/00Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/54Particle separators, e.g. dust precipitators, using ultra-fine filter sheets or diaphragms
    • B01D46/543Particle separators, e.g. dust precipitators, using ultra-fine filter sheets or diaphragms using membranes
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F251/00Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/02Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to polysaccharides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/04Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
    • C08L79/08Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
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    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L87/00Compositions of unspecified macromolecular compounds, obtained otherwise than by polymerisation reactions only involving unsaturated carbon-to-carbon bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/75General characteristics of the apparatus with filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0618Nose
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    • C08L2205/00Polymer mixtures characterised by other features
    • C08L2205/02Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C08L2205/025Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
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    • C08L2205/00Polymer mixtures characterised by other features
    • C08L2205/03Polymer mixtures characterised by other features containing three or more polymers in a blend
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    • C08L2205/00Polymer mixtures characterised by other features
    • C08L2205/14Polymer mixtures characterised by other features containing polymeric additives characterised by shape
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Abstract

The invention discloses a kind of sleep nose cups, belong to medical instruments field.A kind of sleep nose cup of the invention, including bracket, the both ends of the bracket have been respectively fixedly connected with rhinarium, the rhinarium is equipped with snorkel, the ventilation pipe surface is covered with filter membrane, and the rhinarium and internal stent are hollow, and the snorkel is connected to rhinarium and internal stent, the bracket is fabricated from a flexible material, and the internal stent is equipped with sizing iron wire.A kind of sleep of the invention nose cup has structure novel, and very big reduction face enclosure volume obtains comfortable sleep while guaranteeing that patient is able to maintain good mouth, nasal airflow ventilation, while guaranteeing that mask will not be because of the characteristics of rolling etc. is subjected to displacement during sleep.

Description

Nose cup is used in a kind of sleep
Technical field
The present invention relates to a kind of medical instrument, nose cup is used in especially a kind of sleep.
Background technique
OSA (obstructive sleep apnea) patient can occur during sleep mouth, nasal airflow stop circulation up to 10 seconds or For more time, and with symptoms such as blood oxygen saturation declines can draw in general, the attack times of patient every night reach 30 times or more Many serious complication are played, leads to patient daytime drowsiness, often unconsciously falls asleep between talk, failure of memory pays attention to Power cannot be concentrated, work efficiency drop, the variation that can be also in a bad mood with behavior.Restless, dreaminess, the enuresis, impotence, headache from morning Deng.The prior art covers in face when patient falls asleep by using nose cup, mask etc., supplies in sleep procedure for its Continuous aeration Oxygen avoids apnea to guarantee the circulation of its mouthful, nasal airflow in its sleep procedure.But existing respiratory surface cover Product is larger, usually all covers the mouth and nose of patient, although can guarantee mouth, nose ventilation, avoids apnea, mask Volume is larger, mask is usually fixed on head by elastic band etc., it is difficult to ensure that position will not occur for mask in sleep procedure It moves, simultaneously because volume is larger also to make troubles for sleep, great discomfort may be brought.
Summary of the invention
Goal of the invention of the invention is: in view of the above problems, providing a kind of structure novel, greatly diminution mask Volume obtains comfortable sleep, while guaranteeing mask while guaranteeing that patient is able to maintain good mouth, nasal airflow ventilation It will not be because of the sleep nose cup that rolling etc. is subjected to displacement during sleep.
The technical solution adopted by the invention is as follows:
A kind of sleep nose cup, including bracket, the both ends of the bracket have been respectively fixedly connected with rhinarium, have set on the rhinarium Have a snorkel, the ventilation pipe surface is covered with filter membrane, the filter membrane with a thickness of 0.7mm, the filter membrane is by cohering and ventilating Pipe is connected, and the snorkel is made of elastic material, and the rhinarium and internal stent are hollow, the snorkel and rhinarium and bracket Inside connection, the bracket are fabricated from a flexible material, and the internal stent is equipped with sizing iron wire.
By adopting the above-described technical solution, snorkel is placed in nasal meatus, then by support-folding at the shape of suitable nose Shape, by being formed, iron wire is formed, that is, can guarantee that snorkel remains in nasal meatus during sleep, so as to continue Stable is that patient provides gas circulation, avoids apnea, and the gas to circulate in nose cup can be filtered by filter membrane, including The gas of gas and exhalation to sucking carries out evolution filtering, avoids exhaled gas accumulation dirt degree from being slowly increased, influences incoming call The oxygen content of gas;In use for some time, filter membrane is replaceable, to extend the service life of nose cup.
A kind of sleep nose cup of the invention, the filter membrane is by 22 parts of polyallyl acrylamide sodium of mass parts, 8 parts of activity Charcoal, 3 parts of ethyl hydroxy benzoates and 23 parts of anhydrous calcium chloride compositions, the partial size of the anhydrous calcium chloride is less than 500 mesh, the polyallyl The molecular formula of acrylamide sodium is
A kind of sleep nose cup of the invention, the mid-stent are equipped with connection through-hole, and the connection through-hole runs through bracket Upper and lower surface.
By adopting the above-described technical solution, connection through-hole can facilitate the disassembly of appendix, it is convenient to bracket, rhinarium It is timed cleaning with snorkel, to guarantee safety in utilization.
A kind of sleep nose cup of the invention, the connection through-hole are connected with appendix, and the appendix is set on bracket Surface side, the appendix front end pass through connection through-hole, are connected with gasket.
By adopting the above-described technical solution, snorkel can not only be auxiliarily fixed in gasket, while being capable of consolidating for bracket It is fixed that guarantee is provided, increase the frictional force of bracket and face, to reduce a possibility that bracket slides.
A kind of sleep nose cup of the invention, the appendix upper surface are equipped with gas sensor, the gas sensor It is connected to appendix inside, gas circulation status in the gas sensor detection appendix, when gas sensor is in 10s It detects that gas flows, then issues alarm.
By adopting the above-described technical solution, by detection gas circulation status, to apnea feelings occur in patient Lighter warning being issued under condition, stimulates the nervous centralis of patient, auxiliary arouses patient muscle and is at tensioned state, from And it assists avoiding the occurrence of long-time apnea.
A kind of sleep nose cup of the invention, the appendix front end are evenly equipped with stomata, and the stomata is distributed in a ring, institute Stomata is stated to be connected to internal stent.
By adopting the above-described technical solution, stomata can guarantee the stabilization of airflow between appendix and snorkel Property, it avoids during eupnea, since respiration force leads to the rapid unstable of air-flow.
A kind of sleep nose cup of the invention, the gasket are fabricated from a flexible material, and the gasket includes inhaling from top to bottom Attached layer, slow release layer and air-permeable layer.
By adopting the above-described technical solution, gasket can protect skin of face while increasing friction force, avoid rubbing Wiping power is excessive to cause skin of face impaired, and adsorption layer can be further ensured that bracket is not fallen off in nose by Electrostatic Absorption, Slow release layer can slow release drug, reduce the generation of respiratory secretions, thus reduce apnea generation number, play The effect of adjuvant treatment.
A kind of sleep nose cup of the invention, the adsorption layer is by 27 parts of nano indium oxides of mass parts, 13 parts of polyoxygenateds third Enediol, 41 parts of butenoate-graft starch and 16 parts of neopelexes composition, the adsorption layer with a thickness of 0.1cm;The slow release layer is by 6 parts of pseudoephedrine analog derivatives of mass parts, 12 parts of extract from fruit shell of camellia oleifera abel, 8 parts of wood-fibreds, 19 parts of 2- Acrylamide-2-methyl propane sulfonic, 21 parts of guar gum-g- poly- (alginic acid-co- styrene), 4 parts of Folium Artemisiae Argyi extractive liquids and 8 portions of chickens Bone grass extracting solution composition, the structural formula of the pseudoephedrine analog derivative areIt is described slow Release layer with a thickness of 0.4cm;The air-permeable layer is by 30 parts of polyimides of mass parts, 5 parts of polycaprolactones, 19 parts of polylactic acid, and 22 parts O-formyl sodium benzenesulfonate contracting isonicotinoyl hydrazone and 13 parts of lignin fibres composition, the air-permeable layer with a thickness of 0.07cm.
By adopting the above-described technical solution, adsorption layer can generate electrostatic adsorption in face, pad is further increased Frictional force between piece and face;Slow release layer slow release drug, by skin by drug slow-absorbing, said medicine ingredient is not The generation of respiratory secretions can only be reduced, while respiratory tract nerve, muscle can effectively be stimulated, nerve is avoided It is suppressed, it is of flaccid muscles to cause apnea, to play the role of adjuvant treatment;Air-permeable layer has good gas permeability, Comfort level when nose cup uses can be increased, avoided since airtight progress is without autonomous scratching in sleep, to influence nose cup Using effect.
A kind of sleep nose cup of the invention, the rhinarium are equipped with nasal cavity and expand frame, and the nasal cavity expands frame by elastic material It being made, the nasal cavity expansion is set up on the outside of snorkel, and the nasal cavity expands frame front end and is arc-shaped, and elastic deformation occurs outward, The elastic deformation potential energy that the nasal cavity expands frame is 21~27J.
By adopting the above-described technical solution, expanding frame by nasal cavity carries out support expansion to nasal cavity, increase the width of nasal meatus, thus Increase the air inflow of respiratory tract.
In conclusion by adopting the above-described technical solution, the beneficial effects of the present invention are:
1, structure novel, very big reduction face enclosure volume, guarantee patient be able to maintain good mouth, nasal airflow ventilation it is same When, comfortable sleep is obtained, while guaranteeing that mask will not be subjected to displacement because of rolling etc. during sleep.
2, slow release drug, by skin by drug slow-absorbing, said medicine ingredient can not only reduce respiratory tract The generation of secretion, while respiratory tract nerve, muscle can effectively be stimulated, avoid nerve from being suppressed, muscle pine Relaxation causes apnea, to play the role of adjuvant treatment;With good gas permeability, relaxing when nose cup uses can be increased Appropriateness is avoided since airtight progress is without autonomous scratching in sleep, to influence the using effect of nose cup.
Detailed description of the invention
Fig. 1 is a kind of sleep nose cup.
Marked in the figure: 1 is bracket, 2 be rhinarium, and 3 be snorkel, and 4 expand frame for nasal cavity, and 5 be gasket, and 6 be gas sensor, 7 be appendix, and 8 be stomata.
Specific embodiment
With reference to the accompanying drawing, the present invention is described in detail.
In order to which the objects, technical solutions and advantages of invention are more clearly understood, with reference to the accompanying drawings and embodiments, to this Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not For limiting the present invention.
Embodiment 1
As shown in Figure 1, a kind of sleep uses nose cup, including bracket 1, the both ends of bracket 1 to be respectively fixedly connected with rhinarium 2, nose Piece 2 is equipped with snorkel 3, and 3 surface of snorkel is covered with filter membrane, filter membrane with a thickness of 0.7mm, filter membrane is by cohering and snorkel 3 It is connected, snorkel 3 is made of elastic material, 1 inner hollow of rhinarium 2 and bracket, connects inside snorkel 3 and rhinarium 2 and bracket 1 Logical, bracket 1 is fabricated from a flexible material, and sizing iron wire is equipped with inside bracket 1.Connection through-hole is equipped in the middle part of bracket 1, connection through-hole passes through 1 upper and lower surface of perforating branches frame.Connection through-hole is connected with appendix 7, and appendix 7 is set to 1 upper surface side of bracket, and 7 front end of appendix is worn Connection through-hole is crossed, is connected with gasket 5.7 upper surface of appendix is equipped with gas sensor 6, inside gas sensor 6 and appendix 7 Connection, gas sensor 6 detect gas circulation status in appendix 7, when gas sensor 6 detects gas stream in 10s It is dynamic, then issue slight alarm.7 front end of appendix is evenly equipped with stomata 8, and stomata is distributed in a ring, connects inside stomata and bracket 1 It is logical.Gasket 5 is fabricated from a flexible material, and gasket 5 includes adsorption layer, slow release layer and air-permeable layer from top to bottom.Rhinarium 2 is equipped with nasal cavity Expanding frame 4, nasal cavity expands frame 4 and is made of elastic material, and nasal cavity expands frame 4 and is set to 3 outside of snorkel, and nasal cavity expands 4 front end of frame and is arc-shaped, And elastic deformation occurs outward, the elastic deformation potential energy that nasal cavity expands frame 4 is 21~27J.
Adsorption layer is by 27 parts of nano indium oxides of mass parts, 13 parts of polyoxypropyleneglycols, 41 parts of butenoate-graft starch Formed with 16 parts of neopelexes, adsorption layer with a thickness of 0.1cm;Slow release layer is spread out by 6 parts of False path bases of mass parts Biology, 12 parts of extract from fruit shell of camellia oleifera abel, 8 parts of wood-fibreds, 19 parts of 2- acrylamide-2-methyl propane sulfonics, 21 parts of guar gum-g- are poly- (alginic acid-co- styrene), 4 parts of Folium Artemisiae Argyi extractive liquids and 8 parts of Canton love-pea vine extracting solution compositions, the structure of pseudoephedrine analog derivative Formula isSlow release layer with a thickness of 0.4cm;Air-permeable layer is by 30 parts of polyimides of mass parts, and 5 Part polycaprolactone, 19 parts of polylactic acid, 22 parts of o-formyl sodium benzenesulfonate contracting isonicotinoyl hydrazones and 13 parts of lignin fibres compositions, breathe freely Layer with a thickness of 0.07cm.
Filter membrane is by 22 parts of polyallyl acrylamide sodium of mass parts, 8 parts of active carbons, 3 parts of ethyl hydroxy benzoates and 23 parts of anhydrous chlorine Change calcium composition, less than 500 mesh, the molecular formula of polyallyl acrylamide sodium is the partial size of anhydrous calcium chloride
Embodiment 2
Butenoate-graft starch preparation method is as follows,
Step 1: weighing a starch, takes suitable quantity of water as solvent, and adjusting pH value of solution is 4.7, and appropriate isopropanol is added and matches It is made for the suspension that starch quality score is 37%, stirs 30min;
Step 2: according to starch: NaOH is added into solution by NaOH mass ratio 1:0.05, is heated to 30 DEG C, constant temperature 30min is stirred, according to NaOH: allyl chloride is slowly added dropwise into solution by allyl chloride molar ratio 1:1.2, is warming up to 50 DEG C, perseverance Temperature stirring is for 24 hours;
Step 3: filtering takes solid to be scattered in distilled water-ethanol solution that volume ratio is 18:82 again, with acetic acid tune PH to 7 is saved, appropriate distillation water washing is used after suction filtration, is dried to obtain allyl etherization starch;
Step 4: taking a allyl etherization starch, takes suitable quantity of water as solvent, being configured as mass fraction is 37% Suspension is 4.2 with vinegar acid for adjusting pH, is passed through nitrogen as protection gas;
Step 5: in the presence of protective gas according to allyl etherization starch: butenoate: butenoic acid: the tertiary fourth of peroxidating two Butenoate, butenoic acid and di-t-butyl peroxide ether is slowly added dropwise simultaneously into solution in base ether molar ratio 1:1:1.5:1.2, often Temperature stirring 3h, adjusting pH is 7, filtering, takes the dry obtained butenoate-graft starch of solid.
Embodiment 3
Pseudoephedrine analog derivativeSynthetic method it is as follows:
Reagent and condition: (Ia-i) periodic acid, chromium trioxide, glucose isomerase, acetonitrile, room temperature;(Ia-ii) it hydrogenates Sodium, ethyl alcohol, alpha-amylase, room temperature;(Ia-iii) sodium borohydride, DMF are heated to reflux;(Ia-iv) sodium ethoxide, DMF, is heated back Stream.
2- (the 5- chloro-2-methyl phenyl) second -1- alcohol for weighing 1.71g is placed in 150mL there-necked flask, measures 20mL acetonitrile, 0.4g glucose isomerase is added in stirring and dissolving at room temperature, and 0.2g chromium trioxide continues to stir 10min at room temperature, It weighs 2.28g periodic acid and is dissolved in 10mL acetonitrile, be gradually slowly added dropwise to reaction system, the reaction was continued at room temperature 36h.Ia-1 reaction After completely, stop reaction, solvent is concentrated under reduced pressure, by column chromatography, solvent is acetone: ether=1:5 obtains Ia-2.
The Ia-2 for weighing 1.99g is placed in 150mL round-bottomed flask, measures 20mL ethyl alcohol, at room temperature stirring and dissolving, The ethyl hydrazine of 1.83g is added, the alpha-amylase of 0.5g is added, continues to stir 10min at room temperature, weighs 0.48g sodium hydride, room After the lower stirring 18h of temperature, it is heated to reflux 10h.After Ia-2 fully reacting, stops reaction, 0 DEG C is rapidly cooled under condition of ice bath, produce Raw white precipitate, filtering, ethanol washing is dry, obtains Ia-3.
The Ia-3 for weighing 3.07g is placed in 150mL round-bottomed flask, measures the DMF of 15mL, is stirred at room temperature molten Solution, weighs 0.57g sodium borohydride, is dissolved in 5mLDMF, be slowly dropped in round-bottomed flask under conditions of ice bath, continues under ice bath Stir 30min, spontaneous recovery to room temperature, heating reflux reaction 5h.After Ia-3 fully reacting, stop reaction, by column chromatography, Solvent is methanol: methylene chloride=1:4 obtains Ia-4.
The Ia-4 for weighing 3.08g is placed in 150mL round-bottomed flask, measures the DMF of 15mL, is stirred at room temperature molten Solution, weighs 1.02g sodium ethoxide, is dissolved in 5mLDMF, be slowly dropped in round-bottomed flask under conditions of ice bath, continues to stir under ice bath Mix 30min, spontaneous recovery to room temperature, heating reflux reaction 18h.After Ia-4 fully reacting, stop reaction, by column chromatography, Solvent is ethyl alcohol: ethyl acetate=1:10 obtains Ia-5, white solid.
Embodiment 4
The logical preparation method of wood-fibred is as follows,
Step 1 is rounded block wood, 2~3h is steamed in 210~230 DEG C of gas, according to wood: sodium hydroxide: sodium hypochlorite matter Amount is than 1:0.2:0.04, and in water after mixing, 3~4h is boiled in heating;
Step 2 filters to take solid and is again dipped into water, carries out lignin by extruder and wood pulp separates;
Step 3 will take wood pulp electrostatic spinning in the case where voltage is 11.4kV DC electric field to obtain wood-fibred after separation.
Embodiment 5
Guar gum-g- poly- (alginic acid-co- styrene) is synthesized by the following method:
It is added in the 250mL round-bottomed flask equipped with stirring rod, reflux condensing tube, nitrogen conduit and constant pressure funnel 1.2g guar gum and 34mL sodium hydroxide solution (pH=12.5,0.067molL-1), it places it in 60 DEG C of oil baths, stirring point 8.9mmolL is added after dissipating 1h-1Initiator ammonium persulfate, constant temperature 15min, initiation generates free radicals.Then 40 DEG C are cooled to Alginic acid containing 7.2g is added afterwards and (uses 8.5mL 8molL-1Sodium hydroxide neutralizes), 38.8mmolL-1Styrene, 2.8mmol·L-1The mixed solution of crosslinking agent N, N '-methylene-bisacrylamide.70 DEG C are to slowly warm up to after dripping, constant temperature React 3h.Whole experiment process uses nitrogen protection.After reaction, resulting product is placed in air dry oven, 70 It dries at DEG C to constant weight, obtains polymer.
Embodiment 6
Ethyl alcohol (80%, v/v) solution and 30mL of the 30mL containing the isoniazid 2.7428g (20mmol) contain 4.576 0g 0.5mL glacial acetic acid is added under the conditions of 80 DEG C in ethyl alcohol (80%.v/v) the solution mixing of (22mmol) o-formyl sodium benzenesulfonate Heating stirring flow back 2h, have faint yellow solid be precipitated be cooled to room temperature, filter, solid powder with ethanol in proper amount/aqueous solution (1: 1, v/v) it is recrystallized, is filtered, wash dry 2d in vacuum silicon rubber drier with dehydrated alcohol.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.

Claims (6)

1. a kind of sleep nose cup, it is characterised in that: including bracket (1), the both ends of the bracket (1) have been respectively fixedly connected with nose Piece (2), the rhinarium (2) are equipped with snorkel (3), and snorkel (3) surface is covered with filter membrane, the rhinarium (2) and bracket (1) it is connected to inside inner hollow, the snorkel (3) and rhinarium (2) and bracket (1), the bracket (1) is by flexible material system At equipped with sizing iron wire inside the bracket (1);
Connection through-hole is equipped in the middle part of the bracket (1), the connection through-hole runs through bracket (1) upper and lower surface;
The connection through-hole is connected with appendix (7), and the appendix (7) is set to bracket (1) upper surface side, the appendix (7) front end passes through connection through-hole, is connected with gasket (5);The gasket (5) is fabricated from a flexible material, the gasket (5) from up to It down include adsorption layer, slow release layer and air-permeable layer.
2. a kind of sleep nose cup as described in claim 1, it is characterised in that: the filter membrane is by 22 parts of polyallyls of mass parts Acrylamide sodium, 8 parts of active carbons, 3 parts of ethyl hydroxy benzoates and 23 parts of anhydrous calcium chloride compositions, the partial size of the anhydrous calcium chloride are less than The molecular formula of 500 mesh, the polyallyl acrylamide sodium is
3. a kind of sleep nose cup as described in claim 1, it is characterised in that: appendix (7) upper surface is equipped with gas It is connected to inside sensor (6), the gas sensor (6) and appendix (7), the gas sensor (6) detects appendix (7) Middle gas circulation status, when gas sensor (6) in 10s for detect gas flow, then issue alarm.
4. a kind of sleep nose cup as claimed in claim 3, it is characterised in that: appendix (7) front end is evenly equipped with stomata (8), the stomata is distributed in a ring, is connected to inside the stomata and bracket (1).
5. a kind of sleep nose cup as described in claim 1, it is characterised in that: the adsorption layer is nano oxidized by 27 parts of mass parts Indium, 13 parts of polyoxypropyleneglycols, 41 parts of butenoate-graft starch and 16 parts of neopelex compositions, the absorption Layer with a thickness of 0.1cm;The slow release layer is by 6 parts of pseudoephedrine analog derivatives of mass parts, 12 parts of extract from fruit shell of camellia oleifera abel, 8 parts of wood fibres Dimension, 19 parts of 2- acrylamide-2-methyl propane sulfonics, 21 parts of guar gum-g- poly- (alginic acid-co- styrene), 4 portions of folium artemisiae argyis extract Liquid and 8 parts of Canton love-pea vine extracting solution compositions, the structural formula of the pseudoephedrine analog derivative are, The slow release layer with a thickness of 0.4cm;The air-permeable layer is by 30 parts of polyimides of mass parts, 5 parts of polycaprolactones, 19 parts of poly- creams Acid, 22 parts of o-formyl sodium benzenesulfonate contracting isonicotinoyl hydrazones and 13 parts of lignin fibres composition, the air-permeable layer with a thickness of 0.07cm。
6. a kind of sleep nose cup as described in claim 1, it is characterised in that: the rhinarium (2) is equipped with nasal cavity and expands frame (4), the nasal cavity expands frame (4) and is made of elastic material, and the nasal cavity expands frame (4) and is set on the outside of snorkel (3), and the nasal cavity expands Frame (4) front end is arc-shaped, and elastic deformation occurs outward, and the elastic deformation potential energy that the nasal cavity expands frame (4) is 21 ~ 27J.
CN201610825578.XA 2016-09-14 2016-09-14 Nose cup is used in a kind of sleep Expired - Fee Related CN106310480B (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682171A (en) * 1971-03-31 1972-08-08 Baxter Laboratories Inc Nasal cannula
CN201524333U (en) * 2009-10-27 2010-07-14 常文华 Ventilating nose ball with support frame
CN203090140U (en) * 2013-03-01 2013-07-31 杨若 In-nose type inhaler
TW201343213A (en) * 2012-04-26 2013-11-01 I & I Corp Nose wing type nasal oxygen cannula

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140360499A1 (en) * 2013-06-09 2014-12-11 Ronal Peets Intranasal Airway Device
CN207125959U (en) * 2016-09-14 2018-03-23 吕守礼 A kind of sleep nose cup

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682171A (en) * 1971-03-31 1972-08-08 Baxter Laboratories Inc Nasal cannula
CN201524333U (en) * 2009-10-27 2010-07-14 常文华 Ventilating nose ball with support frame
TW201343213A (en) * 2012-04-26 2013-11-01 I & I Corp Nose wing type nasal oxygen cannula
CN203090140U (en) * 2013-03-01 2013-07-31 杨若 In-nose type inhaler

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