CN106310480A - Nasal mask used in sleeping - Google Patents

Nasal mask used in sleeping Download PDF

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Publication number
CN106310480A
CN106310480A CN201610825578.XA CN201610825578A CN106310480A CN 106310480 A CN106310480 A CN 106310480A CN 201610825578 A CN201610825578 A CN 201610825578A CN 106310480 A CN106310480 A CN 106310480A
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Prior art keywords
parts
support
sleep
appendix
breather
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Granted
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CN201610825578.XA
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CN106310480B (en
Inventor
郑浩
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Chengdu Cedisen Biological Technology Co Ltd
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Chengdu Cedisen Biological Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003Accessories therefor, e.g. sensors, vibrators, negative pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • A61M16/0605Means for improving the adaptation of the mask to the patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • A61M16/0605Means for improving the adaptation of the mask to the patient
    • A61M16/0627Means for improving the adaptation of the mask to the patient with sealing means on a part of the body other than the face, e.g. helmets, hoods or domes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D46/00Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/54Particle separators, e.g. dust precipitators, using ultra-fine filter sheets or diaphragms
    • B01D46/543Particle separators, e.g. dust precipitators, using ultra-fine filter sheets or diaphragms using membranes
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F251/00Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/02Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to polysaccharides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/04Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
    • C08L79/08Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L87/00Compositions of unspecified macromolecular compounds, obtained otherwise than by polymerisation reactions only involving unsaturated carbon-to-carbon bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/75General characteristics of the apparatus with filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/06Head
    • A61M2210/0618Nose
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08L2205/00Polymer mixtures characterised by other features
    • C08L2205/02Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C08L2205/025Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
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    • C08L2205/00Polymer mixtures characterised by other features
    • C08L2205/03Polymer mixtures characterised by other features containing three or more polymers in a blend
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    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00Polymer mixtures characterised by other features
    • C08L2205/14Polymer mixtures characterised by other features containing polymeric additives characterised by shape
    • C08L2205/16Fibres; Fibrils

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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Abstract

The invention discloses a nasal mask used in sleeping and belongs to the field of medical apparatuses and instruments. The nasal mask used in sleeping comprises a support, wherein a nasal plate is fixedly connected to two ends of the support respectively, breather tubes are arranged on the nasal plates, the surfaces of the breather tubes are coated with filter membranes, the nasal plates and the support are hollow, the breather tubes are communicated with the inside of the support, the support is made of a flexible material, and a shaped iron wire is arranged inside the support. The nasal mask used in sleeping has the advantages that the nasal mask is novel in structure, the size of the mask is greatly decreased, comfortable sleeping is obtained while good mouth and nose breathing of a patient can be kept, and meanwhile the mask does not displace due to turning and the like during sleeping.

Description

A kind of sleep nose cup
Technical field
The present invention relates to a kind of medical apparatus and instruments, particularly a kind of sleep nose cup.
Background technology
OSA (obstructive sleep apnea) patient can occur during sleeping mouth, nasal airflow stop circulation reaching 10 seconds or For more time, and with degradation symptom under blood oxygen saturation, generally, patient's attack times every night reaches more than 30 times, can draw Play many serious complication, cause patient daytime drowsiness, often fall asleep unconsciously between talking, hypomnesis, note Power can not be concentrated, work efficiency drop, also can be in a bad mood and the change of behavior.Restless, dreaminess, the enuresis, sexual impotence, morning play headache Deng.Prior art, by using nose cup, face shield etc. to cover in face when patient falls asleep, supplies for its Continuous aeration in sleep procedure Oxygen, thus in its sleep procedure, ensure the circulation of its mouthful, nasal airflow, it is to avoid asphyxia.But existing respiratory surface cover body Long-pending relatively big, generally the mouth and nose of patient are all covered, although ensure that mouth, BITONG gas, it is to avoid asphyxia, but, face shield Volume is relatively big, generally by elastic cord etc., face shield is fixed on head, it is difficult to ensure that face shield will not occur position in sleep procedure Move, simultaneously because volume also can be made troubles for sleep relatively greatly, great discomfort may be brought.
Summary of the invention
The goal of the invention of the present invention is: for the problem of above-mentioned existence, it is provided that a kind of novel structure, greatly reduces face shield Volume, while ensureing that patient can keep the ventilation of good mouth, nasal airflow, it is thus achieved that comfortable sleep, ensures face shield simultaneously The sleep nose cup will not being subjected to displacement because of rolling in bed etc..
The technical solution used in the present invention is as follows:
A kind of sleep nose cup, including support, the two ends of described support have been respectively fixedly connected with rhinarium, and described rhinarium sets Having breather, described breather surface to be covered with filter membrane, the thickness of described filter membrane is 0.7mm, and described filter membrane is by cohering and ventilation Pipe is connected, and described breather is made up of elastomeric material, described rhinarium and internal stent hollow, described breather and rhinarium and support Internal connection, described support is fabricated from a flexible material, and described internal stent is provided with sizing iron wire.
Owing to have employed technique scheme, breather is inserted in nasal meatus, then become to be suitable for the shape of nose by support-folding Shape, is shaped by sizing iron wire, can be ensured that breather remains in nasal meatus during sleeping such that it is able to continued Stable provides gas to circulate for patient, it is to avoid asphyxia, and the gas circulated in nose cup can be filtered by filter membrane, including The gas of the gas sucked and exhalation is carried out filtration of evolving, it is to avoid exhaled gas is piled up dirt degree and is slowly increased, and affects incoming call The oxygen content of gas;In use for some time, filter membrane is replaceable, thus extends the service life of nose cup.
A kind of sleep nose cup of the present invention, described filter membrane is by 22 parts of polyallyl acrylamide sodium of mass parts, 8 parts of activity Charcoal, 3 parts of ethyl hydroxybenzoates and 23 parts of anhydrous calcium chloride compositions, the particle diameter of described anhydrous calcium chloride is less than 500 mesh, described polyallyl The molecular formula of acrylamide sodium is
A kind of sleep nose cup of the present invention, described mid-stent is provided with connection through hole, and described connection through hole runs through support Upper and lower surface.
Owing to have employed technique scheme, connect through hole and can facilitate the dismounting of appendix, convenient to support, rhinarium It is timed cleaning with breather, thus ensures safety in utilization.
A kind of sleep nose cup of the present invention, described connection through hole is connected with appendix, and described appendix is located on support Face side, described appendix front end, through connecting through hole, is connected with pad.
Owing to have employed technique scheme, pad can not only assist fixing breather, simultaneously can consolidating for support Guarantee is provided surely, increases the frictional force of support and face, thus reduce the probability of support landing.
A kind of sleep nose cup of the present invention, described appendix upper surface is provided with gas sensor, described gas sensor Connecting with appendix inside, gas circulation status in described gas sensor detection appendix, when gas sensor is in 10s Detect that gas flows, then send warning.
Owing to have employed technique scheme, by detected gas circulation status, thus patient, asphyxia feelings occur Lighter warning will be sent under condition, stimulate the nervus centralis of patient, auxiliary to arouse patient muscle and be at tensioned state, from And assist and avoid the occurrence of long-time asphyxia.
A kind of sleep nose cup of the present invention, described appendix front end is evenly equipped with pore, and described pore is distributed ringwise, institute State pore to connect with internal stent.
Owing to have employed technique scheme, pore ensure that stablizing of airflow between appendix and breather Property, it is to avoid during eupnea, owing to respiration force causes the rapid instability of air-flow.
A kind of sleep nose cup of the present invention, described pad is fabricated from a flexible material, and described pad includes inhaling from top to bottom Attached layer, slow release layer and air-permeable layer.
Owing to have employed technique scheme, pad can protect skin of face while increasing friction force, it is to avoid rubs Wiping power is excessive causes skin of face impaired, by Electrostatic Absorption, adsorption layer can be further ensured that support is not fall off at nose, Slow release layer can delay Slow release, reduces the generation of respiratory secretions, thus reduces the number of times that asphyxia occurs, plays The effect of auxiliary treatment.
A kind of sleep nose cup of the present invention, described adsorption layer is by 27 parts of nano indium oxides of mass parts, 13 parts of polyoxygenated third Enediol, 41 parts of butenoate-graft starchs and 16 parts of dodecylbenzene sodium sulfonate compositions, the thickness of described adsorption layer is 0.1cm;Described slow release layer is by 6 parts of pseudoephedrine analog derivatives of mass parts, 12 parts of extract from fruit shell of camellia oleifera abel, 8 parts of wood fiber, 19 parts of 2- Acrylamide-2-methyl propane sulfonic, 21 parts of guar gum-g-poly-(alginic acid-co-styrene), 4 parts of Folium Artemisiae Argyi extractive liquids and 8 portions of chickens GUCAO extracting solution forms, and the structural formula of described pseudoephedrine analog derivative isDescribed slow The thickness releasing layer is 0.4cm;Described air-permeable layer by 30 parts of polyimides of mass parts, 5 parts of polycaprolactones, 19 parts of polylactic acid, 22 parts O-formyl sodium benzenesulfonate contracting isonicotinoyl hydrazone and 13 parts of lignin fibre compositions, the thickness of described air-permeable layer is 0.07cm.
Owing to have employed technique scheme, adsorption layer can produce electrostatic adsorption at face, increases pad further Frictional force between sheet and face;Slow release layer delays Slow release, is slowly absorbed by medicine by skin, and said medicine composition is not It is only capable of the generation reducing respiratory secretions, respiratory tract nerve, muscle effectively can be stimulated, it is to avoid neural simultaneously It is suppressed, the asphyxia that causes of flaccid muscles, thus plays the effect of auxiliary treatment;Air-permeable layer has good breathability, Comfort level when nose cup uses can be increased, it is to avoid carry out without autonomous scratching due to airtight in sleep, thus affect nose cup Using effect.
A kind of sleep nose cup of the present invention, described rhinarium is provided with nasal cavity and expands frame, and described nasal cavity expands frame by elastomeric material Making, the expansion of described nasal cavity is set up in outside breather, and it is circular arc that described nasal cavity expands frame front end, and elastic deformation outwards occurs, It is 21~27J that described nasal cavity expands the elastic deformation potential energy of frame.
Owing to have employed technique scheme, expand frame by nasal cavity and nasal cavity is carried out support expansion, increase the width of nasal meatus, thus Increase the air inflow of respiratory tract.
In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows:
1, novel structure, very big reduction face enclosure volume, ensureing that patient can keep the same of good mouth, nasal airflow ventilation Time, it is thus achieved that comfortable sleep, ensure that face shield will not be subjected to displacement because of rolling in bed etc. simultaneously.
2, slow Slow release, is slowly absorbed medicine by skin, and said medicine composition can not only reduce respiratory tract The generation of secretions, effectively can stimulate respiratory tract nerve, muscle, it is to avoid nerve is suppressed, muscle pine simultaneously Relaxation causes asphyxia, thus plays the effect of auxiliary treatment;There is good breathability, by increasing capacitance it is possible to increase relaxing when nose cup uses Appropriateness, it is to avoid carry out without autonomous scratching due to airtight in sleep, thus affect the using effect of nose cup.
Accompanying drawing explanation
Fig. 1 is a kind of sleep nose cup.
Labelling in figure: 1 is support, 2 is rhinarium, and 3 is breather, and 4 expand frame for nasal cavity, and 5 is pad, and 6 is gas sensor, 7 is appendix, and 8 is pore.
Detailed description of the invention
Below in conjunction with the accompanying drawings, the present invention is described in detail.
In order to make the purpose of invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, to this Invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, not For limiting the present invention.
Embodiment 1
As it is shown in figure 1, a kind of sleep nose cup, including support 1, the two ends of support 1 have been respectively fixedly connected with rhinarium 2, nose Sheet 2 is provided with breather 3, and breather 3 surface is covered with filter membrane, and the thickness of filter membrane is 0.7mm, and filter membrane is by cohering and breather 3 Being connected, breather 3 is made up of elastomeric material, rhinarium 2 and support 1 inner hollow, and breather 3 is internal with rhinarium 2 and support 1 to be connected Logical, support 1 is fabricated from a flexible material, and support 1 is internal is provided with sizing iron wire.It is provided with connection through hole in the middle part of support 1, connects through hole and pass through Perforating branches frame 1 upper and lower surface.Connecting through hole to be connected with appendix 7, appendix 7 is located at support 1 upper surface side, and appendix 7 front end is worn Cross connection through hole, be connected with pad 5.Appendix 7 upper surface is provided with gas sensor 6, and gas sensor 6 is internal with appendix 7 Connection, gas sensor 6 detects gas circulation status in appendix 7, when gas sensor 6 in 10s for gas stream being detected Dynamic, then send slight chimes of doom.Appendix 7 front end is evenly equipped with pore 8, and pore is distributed ringwise, and pore is internal with support 1 to be connected Logical.Pad 5 is fabricated from a flexible material, and pad 5 includes adsorption layer, slow release layer and air-permeable layer from top to bottom.Rhinarium 2 is provided with nasal cavity Expanding frame 4, nasal cavity expands frame 4 and is made up of elastomeric material, and nasal cavity expands frame 4 and is located at outside breather 3, and it is circular arc that nasal cavity expands frame 4 front end, And outwards there is elastic deformation, it is 21~27J that nasal cavity expands the elastic deformation potential energy of frame 4.
Adsorption layer is by 27 parts of nano indium oxides of mass parts, 13 parts of polyoxypropyleneglycols, 41 parts of butenoate-graft starchs With 16 parts of dodecylbenzene sodium sulfonate compositions, the thickness of adsorption layer is 0.1cm;Slow release layer is spread out by 6 parts of False path bases of mass parts Biology, 12 parts of extract from fruit shell of camellia oleifera abel, 8 parts of wood fiber, 19 parts of 2-acrylamide-2-methyl propane sulfonics, 21 parts of guar gum-g-gather (alginic acid-co-styrene), 4 parts of Folium Artemisiae Argyi extractive liquids and 8 parts of Herba Abri extracting solution compositions, the structure of pseudoephedrine analog derivative Formula isThe thickness of slow release layer is 0.4cm;Air-permeable layer by 30 parts of polyimides of mass parts, 5 Part polycaprolactone, 19 parts of polylactic acid, 22 parts of o-formyl sodium benzenesulfonate contracting isonicotinoyl hydrazones and 13 parts of lignin fibres compositions are ventilative The thickness of layer is 0.07cm.
Filter membrane is by 22 parts of polyallyl acrylamide sodium of mass parts, 8 parts of activated carbons, 3 parts of ethyl hydroxybenzoates and 23 parts of anhydrous chlorine Changing calcium composition, the particle diameter of anhydrous calcium chloride is less than 500 mesh, and the molecular formula of polyallyl acrylamide sodium is
Embodiment 2
The preparation method of butenoate-graft starch is as follows,
Step one: weigh a starch, takes suitable quantity of water as solvent, and regulation pH value of solution is 4.7, adds appropriate isopropanol and joins It is made for the suspension that starch quality mark is 37%, stirs 30min;
Step 2: according to starch: NaOH mass ratio 1:0.05 adds NaOH in solution, is heated to 30 DEG C, constant temperature Stirring 30min, according to NaOH: allyl chloride mol ratio 1:1.2 is slowly added dropwise allyl chloride in solution, is warming up to 50 DEG C, permanent Temperature stirring 24h;
Step 3: filter, take solid and be again scattered in distilled water-ethanol solution that volume ratio is 18:82, adjust with acetic acid Joint pH to 7, uses appropriate distilled water wash, is dried to obtain allyl etherization starch after sucking filtration;
Step 4: take a allyl etherization starch, takes suitable quantity of water as solvent, and being configured as mass fraction is 37% Suspension, is 4.2 with vinegar acid for adjusting pH, is passed through nitrogen as protection gas;
Step 5: according to allyl etherization starch in the presence of protection gas: butenoate: butenoic acid: the tertiary fourth of peroxidating two Base ether mol ratio 1:1:1.5:1.2 is slowly added dropwise butenoate, butenoic acid and di-t-butyl peroxide ether in solution simultaneously, often Temperature stirring 3h, regulation pH is 7, filters, takes solid and be dried prepared butenoate-graft starch.
Embodiment 3
Pseudoephedrine analog derivativeSynthetic method as follows:
Reagent and condition: (Ia-i) periodic acid, chromic acid, glucose isomerase, acetonitrile, room temperature;(Ia-ii) hydrogenation Sodium, ethanol, α-amylase, room temperature;(Ia-iii) sodium borohydride, DMF, it is heated to reflux;(Ia-iv) Sodium ethylate, DMF, heats back Stream.
2-(the 5-chloro-2-methyl phenyl) second-1-alcohol weighing 1.71g is placed in 150mL there-necked flask, measures 20mL acetonitrile, Stirring and dissolving at ambient temperature, adds 0.4g glucose isomerase, 0.2g chromic acid, at room temperature continues stirring 10min, Weigh 2.28g periodic acid and be dissolved in 10mL acetonitrile, be progressively slowly added dropwise to reaction system, under room temperature, continue reaction 36h.Ia-1 reacts After Wan Quan, stopped reaction, concentrating under reduced pressure solvent, by column chromatography, developing solvent is acetone: ether=1:5, obtains Ia-2.
The Ia-2 weighing 1.99g is placed in 150mL round-bottomed flask, measures 20mL ethanol, at ambient temperature stirring and dissolving, Add the ethyl hydrazine of 1.83g, add the α-amylase of 0.5g, at room temperature continue stirring 10min, weigh 0.48g sodium hydride, room After the lower stirring 18h of temperature, it is heated to reflux 10h.After Ia-2 reaction completely, stopped reaction, it is rapidly cooled to 0 DEG C under condition of ice bath, produces Raw white precipitate, filters, washing with alcohol, is dried, obtains Ia-3.
Weigh the Ia-3 of 3.07g, be placed in 150mL round-bottomed flask, measure the DMF of 15mL, stir molten at ambient temperature Solve, weigh 0.57g sodium borohydride, be dissolved in 5mLDMF, be slowly dropped under conditions of ice bath in round-bottomed flask, continue under ice bath Stirring 30min, clear-cutting forestland to room temperature, heating reflux reaction 5h.After Ia-3 reaction completely, stopped reaction, by column chromatography, Developing solvent is methanol: dichloromethane=1:4, obtains Ia-4.
Weigh the Ia-4 of 3.08g, be placed in 150mL round-bottomed flask, measure the DMF of 15mL, stir molten at ambient temperature Solve, weigh 1.02g Sodium ethylate, be dissolved in 5mLDMF, be slowly dropped under conditions of ice bath in round-bottomed flask, continue to stir under ice bath Mix 30min, clear-cutting forestland to room temperature, heating reflux reaction 18h.After Ia-4 reaction completely, stopped reaction, by column chromatography, Developing solvent is ethanol: ethyl acetate=1:10, obtains Ia-5, white solid.
Embodiment 4
The preparation method that the wood fiber is logical is as follows,
Step one, rounds block wood, steams 2~3h at 210~230 DEG C of gas, according to wood: sodium hydroxide: sodium hypochlorite matter Amount ratio 1:0.2:0.04, in water after mix homogeneously, heated and boiled 3~4h;
Step 2, crosses leaching solid and is again dipped in water, carry out lignin by extruder and separate with wood pulp;
Step 3, after separating, will take wood pulp electrostatic spinning under voltage is 11.4kV DC electric field and obtain the wood fiber.
Embodiment 5
Guar gum-g-poly-(alginic acid-co-styrene) synthesizes by the following method:
Add in equipped with the 250mL round-bottomed flask of stirring rod, reflux condensing tube, nitrogen conduit and constant pressure funnel 1.2g guar gum and 34mL sodium hydroxide solution (pH=12.5,0.067mol L-1), it is placed in 60 DEG C of oil baths, stirring point 8.9mmol L is added after dissipating 1h-1Initiator ammonium persulfate, constant temperature 15min, cause produce free radical.Then 40 DEG C it are cooled to Rear addition (uses 8.5mL 8mol L containing 7.2g alginic acid-1Sodium hydroxide neutralizes), 38.8mmol L-1Styrene, 2.8mmol·L-1The mixed solution of cross-linking agent N, N '-methylene-bisacrylamide.70 DEG C it are to slowly warm up to, constant temperature after dripping Reaction 3h.Whole experimentation is all protected with nitrogen.After reaction terminates, the product of gained is placed in air dry oven, 70 It is dried at DEG C to constant weight, obtains polymer.
Embodiment 6
30mL ethanol (80%, the v/v) solution containing 2.7428g (20mmol) isoniazid and 30mL are containing 4.576 0g (22mmol) ethanol (80%.v/v) the solution mixing of o-formyl sodium benzenesulfonate. add 0.5mL glacial acetic acid. under the conditions of 80 DEG C Heated and stirred backflow 2h, has faint yellow solid to separate out. it is cooled to room temperature, and sucking filtration, pressed powder ethanol in proper amount/aqueous solution (1: 1, v/v) carry out recrystallization, filter, use absolute ethanol washing. in vacuum silicon rubber exsiccator, it is dried 2d.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention Any amendment, equivalent and the improvement etc. made within god and principle, should be included within the scope of the present invention.

Claims (9)

1. a sleep nose cup, it is characterised in that: include that support (1), the two ends of described support (1) have been respectively fixedly connected with nose Sheet (2), described rhinarium (2) is provided with breather (3), and described breather (3) surface is covered with filter membrane, and the thickness of described filter membrane is 0.7mm, described filter membrane is connected with breather (3) by cohering, and described breather (3) is made up of elastomeric material, described rhinarium (2) With support (1) inner hollow, described breather (3) is internal with rhinarium (2) and support (1) to be connected, and described support (1) is by flexible material Material is made, and described support (1) is internal is provided with sizing iron wire.
2. a kind of sleep nose cup as claimed in claim 1, it is characterised in that: described filter membrane is by 22 parts of polyallyl of mass parts Acrylamide sodium, 8 parts of activated carbons, 3 parts of ethyl hydroxybenzoates and 23 parts of anhydrous calcium chloride compositions, the particle diameter of described anhydrous calcium chloride is less than 500 mesh, the molecular formula of described polyallyl acrylamide sodium is
3. a kind of sleep nose cup as described in claim 2, it is characterised in that: described support (1) middle part is provided with connection through hole, Described connection through hole runs through support (1) upper and lower surface.
4. a kind of sleep nose cup, it is characterised in that: described connection through hole and appendix (7) phase Even, described appendix (7) is located at support (1) upper surface side, and described appendix (7) front end is through connecting through hole, with pad (5) phase Even.
5. a kind of sleep nose cup as claimed in claim 4, it is characterised in that: described appendix (7) upper surface is provided with gas Sensor (6), described gas sensor (6) is internal with appendix (7) to be connected, described gas sensor (6) detection appendix (7) Middle gas circulation status, when gas sensor (6) in 10s for detecting that gas flows, then send warning.
6. a kind of sleep nose cup as claimed in claim 5, it is characterised in that: described appendix (7) front end is evenly equipped with pore (8), described pore is distributed ringwise, and described pore is internal with support (1) to be connected.
7. a kind of sleep nose cup as described in claim 4 or 5, it is characterised in that: described pad (5) is by flexible material system Becoming, described pad (5) includes adsorption layer, slow release layer and air-permeable layer from top to bottom.
8. a kind of sleep nose cup as claimed in claim 6, it is characterised in that: described adsorption layer is nano oxidized by mass parts 27 parts Indium, 13 parts of polyoxypropyleneglycols, 41 parts of butenoate-graft starchs and 16 parts of dodecylbenzene sodium sulfonate compositions, described absorption The thickness of layer is 0.1cm;Described slow release layer is by 6 parts of pseudoephedrine analog derivatives of mass parts, 12 parts of extract from fruit shell of camellia oleifera abel, and 8 parts of wood are fine Dimension, 19 parts of 2-acrylamide-2-methyl propane sulfonics, 21 parts of guar gum-g-poly-(alginic acid-co-styrene), 4 parts of Folium Artemisiae Argyi extractive liquids With 8 parts of Herba Abri extracting solution compositions, the structural formula of described pseudoephedrine analog derivative is , the thickness of described slow release layer is 0.4cm;Described air-permeable layer is by 30 parts of polyimides of mass parts, 5 parts of polycaprolactones, 19 parts of poly-breasts Acid, 22 parts of o-formyl sodium benzenesulfonate contracting isonicotinoyl hydrazones and 13 parts of lignin fibre compositions, the thickness of described air-permeable layer is 0.07cm。
9. a kind of OSA patient as described in claim 3 or 6 or 7 pastes with nose, it is characterised in that: described rhinarium (2) is provided with nose Frame (4) is expanded in chamber, and described nasal cavity expands frame (4) and is made up of elastomeric material, and described nasal cavity expands frame (4) and is located at breather (3) outside, described It is circular arc that nasal cavity expands frame (4) front end, and elastic deformation outwards occurs, described nasal cavity expand the elastic deformation potential energy of frame (4) be 21 ~ 27J。
CN201610825578.XA 2016-09-14 2016-09-14 Nose cup is used in a kind of sleep Expired - Fee Related CN106310480B (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682171A (en) * 1971-03-31 1972-08-08 Baxter Laboratories Inc Nasal cannula
CN201524333U (en) * 2009-10-27 2010-07-14 常文华 Ventilating nose ball with support frame
CN203090140U (en) * 2013-03-01 2013-07-31 杨若 In-nose type inhaler
TW201343213A (en) * 2012-04-26 2013-11-01 I & I Corp Nose wing type nasal oxygen cannula
US20140360499A1 (en) * 2013-06-09 2014-12-11 Ronal Peets Intranasal Airway Device
CN207125959U (en) * 2016-09-14 2018-03-23 吕守礼 A kind of sleep nose cup

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682171A (en) * 1971-03-31 1972-08-08 Baxter Laboratories Inc Nasal cannula
CN201524333U (en) * 2009-10-27 2010-07-14 常文华 Ventilating nose ball with support frame
TW201343213A (en) * 2012-04-26 2013-11-01 I & I Corp Nose wing type nasal oxygen cannula
CN203090140U (en) * 2013-03-01 2013-07-31 杨若 In-nose type inhaler
US20140360499A1 (en) * 2013-06-09 2014-12-11 Ronal Peets Intranasal Airway Device
CN207125959U (en) * 2016-09-14 2018-03-23 吕守礼 A kind of sleep nose cup

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