CN106390261A - Nasal mask for OSA patient - Google Patents
Nasal mask for OSA patient Download PDFInfo
- Publication number
- CN106390261A CN106390261A CN201610825553.XA CN201610825553A CN106390261A CN 106390261 A CN106390261 A CN 106390261A CN 201610825553 A CN201610825553 A CN 201610825553A CN 106390261 A CN106390261 A CN 106390261A
- Authority
- CN
- China
- Prior art keywords
- parts
- support
- nose cup
- patient
- osa patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000463 material Substances 0.000 claims abstract description 8
- 210000001331 nose Anatomy 0.000 claims description 31
- 210000003928 nasal cavity Anatomy 0.000 claims description 16
- 229920002472 Starch Polymers 0.000 claims description 11
- 238000001179 sorption measurement Methods 0.000 claims description 11
- 239000008107 starch Substances 0.000 claims description 11
- 235000019698 starch Nutrition 0.000 claims description 11
- 239000007789 gas Substances 0.000 claims description 10
- 239000012528 membrane Substances 0.000 claims description 10
- 239000011148 porous material Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- -1 isonicotinoyl hydrazones Chemical class 0.000 claims description 7
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical group [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical class CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 claims description 6
- LPXFITACVAQQAL-UHFFFAOYSA-M sodium;prop-2-enoylazanide Chemical compound [Na+].[NH-]C(=O)C=C LPXFITACVAQQAL-UHFFFAOYSA-M 0.000 claims description 6
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 5
- 230000005489 elastic deformation Effects 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 229920005610 lignin Polymers 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 229940077386 sodium benzenesulfonate Drugs 0.000 claims description 4
- 241000526900 Camellia oleifera Species 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
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- 244000007835 Cyamopsis tetragonoloba Species 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- JCHMFMSWRWHRFI-HMMYKYKNSA-N ethyl (2e)-2-[(2,5-dichlorophenyl)hydrazinylidene]-2-(2,6-dimethylmorpholin-4-yl)acetate Chemical group C1C(C)OC(C)CN1/C(C(=O)OCC)=N/NC1=CC(Cl)=CC=C1Cl JCHMFMSWRWHRFI-HMMYKYKNSA-N 0.000 claims 1
- 229910052738 indium Inorganic materials 0.000 claims 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract description 8
- 229910052742 iron Inorganic materials 0.000 abstract description 4
- 238000004513 sizing Methods 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 22
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 17
- 238000003756 stirring Methods 0.000 description 16
- 238000000034 method Methods 0.000 description 14
- 208000001797 obstructive sleep apnea Diseases 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 13
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- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 208000008784 apnea Diseases 0.000 description 6
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
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- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 244000303965 Cyamopsis psoralioides Species 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229960000583 acetic acid Drugs 0.000 description 3
- 238000004440 column chromatography Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 238000009423 ventilation Methods 0.000 description 3
- OSDWBNJEKMUWAV-UHFFFAOYSA-N Allyl chloride Chemical compound ClCC=C OSDWBNJEKMUWAV-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 229920001131 Pulp (paper) Polymers 0.000 description 2
- 108700040099 Xylose isomerases Proteins 0.000 description 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
- 235000011148 calcium chloride Nutrition 0.000 description 2
- 229940117975 chromium trioxide Drugs 0.000 description 2
- WGLPBDUCMAPZCE-UHFFFAOYSA-N chromium trioxide Inorganic materials O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 2
- GAMDZJFZMJECOS-UHFFFAOYSA-N chromium(6+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Cr+6] GAMDZJFZMJECOS-UHFFFAOYSA-N 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 229910003437 indium oxide Inorganic materials 0.000 description 2
- PJXISJQVUVHSOJ-UHFFFAOYSA-N indium(iii) oxide Chemical class [O-2].[O-2].[O-2].[In+3].[In+3] PJXISJQVUVHSOJ-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 238000006748 scratching Methods 0.000 description 2
- 230000002393 scratching effect Effects 0.000 description 2
- 239000012279 sodium borohydride Substances 0.000 description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 description 2
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 2
- 238000000967 suction filtration Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 241001614291 Anoplistes Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010027940 Mood altered Diseases 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 238000004140 cleaning Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- LSXWFXONGKSEMY-UHFFFAOYSA-N di-tert-butyl peroxide Chemical compound CC(C)(C)OOC(C)(C)C LSXWFXONGKSEMY-UHFFFAOYSA-N 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000010041 electrostatic spinning Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- WHRIKZCFRVTHJH-UHFFFAOYSA-N ethylhydrazine Chemical compound CCNN WHRIKZCFRVTHJH-UHFFFAOYSA-N 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 229960003350 isoniazid Drugs 0.000 description 1
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 description 1
- 201000001997 microphthalmia with limb anomalies Diseases 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
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- 150000003254 radicals Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
- A61M16/0666—Nasal cannulas or tubing
- A61M16/0672—Nasal cannula assemblies for oxygen therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a nasal mask for an OSA patient, and belongs to the field of medical apparatuses and instruments. The nasal mask for the OSA patient comprises a support. The two ends of the support are fixedly connected with nasal plates respectively, a breather pipe is arranged on each nasal plate, the nasal plates and the support are hollow, the breather pipes and the nasal plates are communicated with the interior of the support, the support is made from flexible materials, and a sizing iron wire is arranged inside the support. The nasal mask for the OSA patient has the advantages that the structure is novel, the size of the mask is greatly reduced, the comfortable sleep is obtained while it is ensured that a patient can keep good mouth and nose circular air, and meanwhile it is ensured that the mask will not deflect when the patient turns over during sleeping.
Description
Technical field
The present invention relates to a kind of medicine equipment, particularly a kind of OAS patient's nose cup.
Background technology
OSA (obstructive sleep apnea) patient during sleeping can occur mouth, nasal airflow stop circulation reaching 10 seconds or
For more time, and with symptoms such as blood oxygen saturation declines, generally, patient's attack times every night reach more than 30 times, can draw
Play many serious complication, lead to patient daytime drowsiness, often unconsciously fall asleep between talking, failure of memory, note
Power can not be concentrated, work efficiency drop, the change also being in a bad mood with behavior.Restless, dreaminess, the enuresis, impotence, headache from morning
Deng.Prior art covers in face by using nose cup, mask etc. when patient falls asleep, and supplies for its Continuous aeration in sleep procedure
Oxygen, thus ensure the circulation of its mouthful, nasal airflow, it is to avoid apnea in its sleep procedure.But existing respiratory surface cover body
Long-pending larger, generally the mouth and nose of patient are all covered although ensure that mouth, nose ventilation, it is to avoid apnea, but, mask
Volume is larger, generally by elastic band etc., mask is fixed on head, it is difficult to ensure that mask will not occur position in sleep procedure
Move, simultaneously because volume is larger also can make troubles for sleep, great discomfort may be brought.
Content of the invention
The goal of the invention of the present invention is：For above-mentioned problem, provide a kind of structure novel, greatly reduce mask
Volume, while ensureing that patient can keep good mouth, nasal airflow ventilation, obtains comfortable sleep, ensures mask simultaneously
Will not be because of OSA patient's nose cup that rolling etc. is subjected to displacement during sleep.
The technical solution used in the present invention is as follows：
A kind of OSA patient's nose cup of the present invention, including support, the two ends of described support have been respectively fixedly connected with rhinarium,
Described rhinarium is provided with breather pipe, described rhinarium and internal stent hollow, and described breather pipe is connected with rhinarium and internal stent, institute
State support to be fabricated from a flexible material, described internal stent is provided with sizing iron wire.
Due to employing technique scheme, breather pipe is inserted in nasal meatus, then support-folding is become to be suitable for the shape of nose
Shape, by shaping, iron wire is shaped, you can ensure that breather pipe remains in nasal meatus such that it is able to continue in during sleeping
Stable provides gas to circulate for patient, it is to avoid apnea.
A kind of OSA patient's nose cup of the present invention, described mid-stent is provided with connection through hole, and described connection through hole runs through
Frame upper and lower surface.
Due to employing technique scheme, connect through hole and can facilitate the dismounting of appendix, conveniently to support, rhinarium
It is timed cleaning with breather pipe, thus ensureing safety in utilization.
A kind of OSA patient's nose cup of the present invention, described connection through hole is connected with appendix, and described appendix is located at support
Upper surface side, described appendix front end passes through and connects through hole, is connected with pad.
Due to employing technique scheme, pad can not only assist fixing breather pipe, can be consolidating of support simultaneously
Fixed offer ensures, increases the frictional force of support and face, thus reducing the possibility of support landing.
A kind of OSA patient's nose cup of the present invention, described appendix front end is evenly equipped with pore, and described pore ringwise divides
Cloth, described pore is connected with internal stent.
Due to employing technique scheme, pore ensure that stablizing of airflow between appendix and breather pipe
Property, it is to avoid during eupnea, because respiration force leads to the rapid unstable of air-flow.
A kind of OSA patient's nose cup of the present invention, described pad is fabricated from a flexible material, and described pad includes from top to bottom
Adsorption layer, slow release layer and air-permeable layer.
Due to employing technique scheme, pad can protect skin of face while increasing friction force, it is to avoid rubs
Wiping power is excessive to lead to skin of face impaired, by Electrostatic Absorption, adsorption layer can be further ensured that support is not fall off in nose,
Slow release layer can delay Slow release, reduces the generation of respiratory secretions, thus reducing the number of times of apnea generation, plays
The effect of auxiliary treatment.
A kind of OSA patient's nose cup of the present invention, described adsorption layer is by 27 parts of nano indium oxides of mass parts, 13 parts of polyoxygenated
Propylene glycol, 41 parts of butenoate-graft starch and 16 parts of neopelexes form, and the thickness of described adsorption layer is
0.1cm；Described slow release layer is by 6 parts of pseudoephedrine analog derivatives of mass parts, 12 parts of extract from fruit shell of camellia oleifera abel, 8 parts of wood-fibreds, 19 parts of 2-
Acrylamide-2-methyl propane sulfonic, 21 parts of guar gum-g- are poly- (alginic acid-co- styrene), 4 parts of Folium Artemisiae Argyi extractive liquids and 8 portions of chickens
Bone grass extract forms, and the structural formula of described pseudoephedrine analog derivative isDescribed slow
The thickness releasing layer is 0.4cm；Described air-permeable layer by 30 parts of polyimides of mass parts, 5 parts of polycaprolactones, 19 parts of PLAs, 22 parts
O-formyl sodium benzenesulfonate contracting isonicotinoyl hydrazone and 13 parts of lignin fibre compositions, the thickness of described air-permeable layer is 0.07cm.
Due to employing technique scheme, adsorption layer can produce electrostatic adsorption in face, increases pad further
Frictional force between piece and face；Slow release layer delays Slow release, is slowly absorbed medicine by skin, and said medicine composition is not
The generation of respiratory secretions only can be reduced, respiratory tract nerve, muscle effectively can be stimulated, it is to avoid nerve simultaneously
Being suppressed, of flaccid muscles causing apnea, thus playing the effect of auxiliary treatment；Air-permeable layer has good gas permeability,
Comfort level when nose cup uses can be increased, it is to avoid carry out no autonomous scratching due to airtight in sleep, thus affecting nose cup
Using effect.
A kind of OSA patient's nose cup of the present invention, described rhinarium is provided with nasal cavity and expands frame, and described nasal cavity expands frame by elastic material
Material is made, and described nasal cavity expansion is set up in outside breather pipe, and it is in circular arc that described nasal cavity expands frame front end, and elastic shape outwards occurs
Become, the elastic deformation potential energy that described nasal cavity expands frame is 21～27J.
Due to employing technique scheme, frame is expanded by nasal cavity nasal cavity is carried out with support expansion, increase the width of nasal meatus, thus
Increase the air inflow of respiratory tract.
A kind of OSA patient's nose cup of the present invention, described appendix upper surface is covered with filter membrane, and described filter membrane is by mass parts 22
Part polyallyl acrylamide sodium, 8 parts of activated carbons, 3 parts of ethyl hydroxy benzoates and 23 parts of anhydrous calcium chlorides compositions, described anhydrous calcium chloride
Particle diameter be less than 500 mesh, the molecular formula of described polyallyl acrylamide sodium is
, described filter membrane connected with breather pipe.
Due to employing technique scheme, the gas of exhalation can be filtered by filter membrane, it is to avoid exhaled gas are piled up
Dirty degree is slowly increased, the oxygen content of impact incoming call gas.
In sum, due to employing technique scheme, the invention has the beneficial effects as follows：
1st, structure is novel, very big reduction face enclosure volume, ensure patient can keep good mouth, nasal airflow ventilation same
When, obtain comfortable sleep, ensure that mask will not be subjected to displacement because of rolling etc. during sleep simultaneously.
2nd, delay Slow release, by skin, medicine is slowly absorbed, said medicine composition can not only reduce respiratory tract
The generation of secretion, effectively can be stimulated to respiratory tract nerve, muscle, it is to avoid nerve is suppressed, muscle pine simultaneously
Relaxation causes apnea, thus playing the effect of auxiliary treatment；There is good gas permeability, by increasing capacitance it is possible to increase relaxing when nose cup uses
Appropriateness, it is to avoid carry out no autonomous scratching due to airtight in sleep, thus affecting the using effect of nose cup.
Brief description
Fig. 1 is a kind of OSA patient's nose cup.
In figure marks：1 is support, and 2 is rhinarium, and 3 is breather pipe, and 4 expand frame for nasal cavity, and 5 is pad, and 6 is filter membrane, and 7 is defeated
Tracheae, 8 is pore.
Specific embodiment
Below in conjunction with the accompanying drawings, the present invention is described in detail.
In order that the purpose of invention, technical scheme and advantage become more apparent, below in conjunction with drawings and Examples, to this
Invention is further elaborated.It should be appreciated that specific embodiment described herein is only in order to explain the present invention, not
For limiting the present invention.
Embodiment 1
As shown in figure 1, a kind of OSA patient's nose cup, including support 1, the two ends of support 1 have been respectively fixedly connected with rhinarium 2,
Rhinarium 2 is provided with breather pipe 3, rhinarium 2 and support 1 inner hollow, breather pipe 3 and rhinarium 2 and support 1 is internal connects, support 1 by
Flexible material is made, and is provided with sizing iron wire inside support 1.It is provided with connection through hole in the middle part of support 1, connect through hole and run through on support 1
Lower surface.Connect through hole to be connected with appendix 7, located at support 1 upper surface side, appendix 7 front end passes through to connect and leads to appendix 7
Hole, is connected with pad 5.Appendix 7 front end is evenly equipped with pore 8, and pore 8 is ringwise distributed, and pore 8 is internal with support 1 to be connected.Pad
Piece 5 is fabricated from a flexible material, and pad 5 includes adsorption layer, slow release layer and air-permeable layer from top to bottom.Rhinarium 2 is provided with nasal cavity and expands frame
4, nasal cavity expands frame 4 and is made up of elastomeric material, and nasal cavity expands frame 4 outside breather pipe 3, and it is in circular arc that nasal cavity expands frame 4 front end, and to
Outer generation elastic deformation, the elastic deformation potential energy that nasal cavity expands frame 4 is 21～27J.
Adsorption layer is by 27 parts of nano indium oxides of mass parts, 13 parts of polyoxypropyleneglycols, 41 parts of butenoate-graft starch
Form with 16 parts of neopelexes, the thickness of described adsorption layer is 0.1cm；Slow release layer is by 6 parts of pseudoephedrines of mass parts
Analog derivative, 12 parts of extract from fruit shell of camellia oleifera abel, 8 parts of wood-fibreds, 19 parts of 2- acrylamide-2-methyl propane sulfonics, 21 parts of guar gum-g-
Poly- (alginic acid-co- styrene), 4 parts of Folium Artemisiae Argyi extractive liquids and 8 parts of Canton love-pea vine extract compositions, the knot of pseudoephedrine analog derivative
Structure formula isThe thickness of slow release layer is 0.4cm；Air-permeable layer is by 30 parts of polyamides Asias of mass parts
Amine, 5 parts of polycaprolactones, 19 parts of PLAs, 22 parts of o-formyl sodium benzenesulfonate contracting isonicotinoyl hydrazones and 13 parts of lignin fibre compositions,
The thickness of air-permeable layer is 0.07cm.
Appendix 7 upper surface is covered with filter membrane 6, filter membrane by 22 parts of polyallyl acrylamide sodium of mass parts, 8 parts of activated carbons, 3
Part ethyl hydroxy benzoate and 23 parts of anhydrous calcium chlorides compositions, the particle diameter of anhydrous calcium chloride is less than 500 mesh, polyallyl acrylamide sodium
Molecular formula is
, filter membrane 6 connected with breather pipe 7.
Embodiment 2
The preparation method of butenoate-graft starch is as follows,
Step one：Weigh a starch, take suitable quantity of water as solvent, adjusting pH value of solution is 4.7, adds appropriate isopropanol to join
It is made for the suspension that starch quality fraction is 37%, stir 30min；
Step 2：According to starch：NaOH mass ratio 1:0.05 adds NaOH in solution, is heated to 30 DEG C, constant temperature
Stirring 30min, according to NaOH：Allyl chloride mol ratio 1:1.2 are slowly added dropwise allyl chloride in solution, are warming up to 50 DEG C, permanent
Temperature stirring 24h；
Step 3：Filter, taking solid to be again scattered in volume ratio is 18:In 82 distilled water-ethanol solution, adjusted with acetic acid
Section pH to 7, distills water washing with appropriate after suction filtration, is dried to obtain allyl etherization starch；
Step 4：Take a allyl etherization starch, take suitable quantity of water as solvent, being configured as mass fraction is 37%
Suspension, is 4.2 with vinegar acid for adjusting pH, is passed through nitrogen as shielding gas；
Step 5：According to allyl etherization starch in the presence of shielding gas：Butenoate：Butenoic acid：The tertiary fourth of peroxidating two
Base ether mol ratio 1:1:1.5:1.2 are slowly added dropwise butenoate, butenoic acid and di-t-butyl peroxide ether, often in solution simultaneously
Temperature stirring 3h, adjusting pH is 7, filters, and takes solid to be dried and butenoate-graft starch is obtained.
Embodiment 3
Pseudoephedrine analog derivativeSynthetic method as follows：
Reagent and condition：(Ia-i) periodic acid, chromium trioxide, glucose isomerase, acetonitrile, room temperature；(Ia-ii) hydrogenate
Sodium, ethanol, AMS, room temperature；(Ia-iii) sodium borohydride, DMF, it is heated to reflux；(Ia-iv) caustic alcohol, DMF, heats back
Stream.
2- (the 5- chloro-2-methyl phenyl) second -1- alcohol weighing 1.71g is placed in 150mL there-necked flask, measures 20mL acetonitrile,
Stirring and dissolving at ambient temperature, adds 0.4g glucose isomerase, 0.2g chromium trioxide, continues stirring 10min at room temperature,
Weigh 2.28g periodic acid and be dissolved in 10mL acetonitrile, be progressively slowly added dropwise to reaction system, under room temperature, continue reaction 36h.Ia-1 reacts
After completely, stop reaction, reduced pressure concentration solvent, by column chromatography, solvent is acetone：Ether=1:5, obtain Ia-2.
The Ia-2 weighing 1.99g is placed in 150mL round-bottomed flask, measures 20mL ethanol, at ambient temperature stirring and dissolving,
Add the ethyl hydrazine of 1.83g, add the AMS of 0.5g, continue stirring 10min at room temperature, weigh 0.48g sodium hydride, room
After temperature lower stirring 18h, it is heated to reflux 10h.After Ia-2 reaction completely, stop reaction, under condition of ice bath, be rapidly cooled to 0 DEG C, produce
Raw white precipitate, filters, and ethanol washs, and is dried, obtains Ia-3.
Weigh the Ia-3 of 3.07g, be placed in 150mL round-bottomed flask, measure the DMF of 15mL, stir molten at ambient temperature
Solution, weighs 0.57g sodium borohydride, is dissolved in 5mLDMF, be slowly dropped in round-bottomed flask under conditions of ice bath, continues under ice bath
Stirring 30min, clear-cutting forestland to room temperature, heating reflux reaction 5h.After Ia-3 reaction completely, stop reaction, by column chromatography,
Solvent is methyl alcohol：Dichloromethane=1:4, obtain Ia-4.
Weigh the Ia-4 of 3.08g, be placed in 150mL round-bottomed flask, measure the DMF of 15mL, stir molten at ambient temperature
Solution, weighs 1.02g caustic alcohol, is dissolved in 5mLDMF, be slowly dropped in round-bottomed flask under conditions of ice bath, continues to stir under ice bath
Mix 30min, clear-cutting forestland to room temperature, heating reflux reaction 18h.After Ia-4 reaction completely, stop reaction, by column chromatography,
Solvent is ethanol：Ethyl acetate=1:10, obtain Ia-5, white solid.
Embodiment 4
The preparation method that wood-fibred leads to is as follows,
Step one, rounds block wood, steams 2～3h in 210～230 DEG C of gas, according to wood：NaOH：Sodium hypochlorite matter
Amount compares 1:0.2:0.04, after mixing in water, 3～4h is boiled in heating；
Step 2, filters to take solid and is again dipped in water, carries out lignin by extruder and separates with wood pulp；
Step 3, after separation, will take wood pulp electrostatic spinning under voltage is for 11.4kV DC electric field to obtain wood-fibred.
Embodiment 5
Guar gum-g- poly- (alginic acid-co- styrene) synthesizes by the following method：
250mL round-bottomed flask equipped with stirring rod, reflux condensing tube, nitrogen conduit and constant pressure funnel adds
1.2g guar gum and 34mL sodium hydroxide solution (pH=12.5,0.067mol L-1), it is placed in 60 DEG C of oil baths, stirring point
8.9mmol L is added after scattered 1h-1Initiator ammonium persulfate, constant temperature 15min, cause produce free radical.Then it is cooled to 40 DEG C
Add alginic acid containing 7.2g afterwards (with 8.5mL 8mol L-1NaOH neutralizes), 38.8mmol L-1Styrene,
2.8mmol·L-1The mixed solution of crosslinking agent N, N '-methylene-bisacrylamide.It is to slowly warm up to 70 DEG C, constant temperature after dripping
Reaction 3h.Whole experiment process is all protected with nitrogen.After reaction terminates, the product of gained is placed in air dry oven, 70
It is dried to constant weight at DEG C, obtain polymer.
Embodiment 6
30mL contains ethanol (80%, the v/v) solution of 2.7428g (20mmol) isoniazid and 30mL contains 4.576 0g
(22mmol) ethanol (80%.v/v) the solution mixing of o-formyl sodium benzenesulfonate. add 0.5mL glacial acetic acid. under the conditions of 80 DEG C
Heating stirring backflow 2h, has faint yellow solid to separate out. it is cooled to room temperature, suction filtration, the pressed powder ethanol in proper amount/aqueous solution (1：
1, v/v) recrystallized, filter, use absolute ethanol washing. 2d is dried in vacuum silicon rubber drier.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Any modification, equivalent and improvement made within god and principle etc., should be included within the scope of the present invention.
Claims (8)
1. a kind of OSA patient's nose cup it is characterised in that：Including support（1）, described support（1）Two ends be respectively fixedly connected with
There is rhinarium（2）, described rhinarium（2）It is provided with breather pipe（3）, described rhinarium（2）And support（1）Inner hollow, described breather pipe
（3）With rhinarium（2）And support（1）Internal connection, described support（1）It is fabricated from a flexible material, described support（1）Inside is provided with fixed
Sections silk.
2. a kind of OSA patient's nose cup as described in claim 1 it is characterised in that：Described support（1）It is logical that middle part is provided with connection
Hole, described connection through hole runs through support（1）Upper and lower surface.
3. as claimed in claim 2 a kind of OSA patient's nose cup it is characterised in that：Described connection through hole and appendix（7）Phase
Even, described appendix（7）Located at support（1）Upper surface side, described appendix（7）Front end passes through and connects through hole, with pad（5）Phase
Even.
4. as claimed in claim 3 a kind of OSA patient's nose cup it is characterised in that：Described appendix（7）Front end is evenly equipped with gas
Hole（8）, described pore is ringwise distributed, described pore and support（1）Internal connection.
5. a kind of OSA patient's nose cup as described in claim 3 or 4 it is characterised in that：Described pad（5）By flexible material
Make, described pad（5）Include adsorption layer, slow release layer and air-permeable layer from top to bottom.
6. as claimed in claim 5 a kind of OSA patient's nose cup it is characterised in that：Described adsorption layer is by 27 parts of nano oxygen of mass parts
Change indium, 13 parts of polyoxypropyleneglycols, 41 parts of butenoate-graft starch and 16 parts of neopelex compositions, described absorption
The thickness of layer is 0.1cm；, by 6 parts of pseudoephedrine analog derivatives of mass parts, 12 parts of extract from fruit shell of camellia oleifera abel, 8 parts of wood are fine for described slow release layer
Dimension, 19 parts of 2- acrylamide-2-methyl propane sulfonics, 21 parts of guar gum-g- gather（Alginic acid-co- styrene）, 4 parts of Folium Artemisiae Argyi extractive liquids
Form with 8 parts of Canton love-pea vine extracts, the structural formula of described pseudoephedrine analog derivative is,
The thickness of described slow release layer is 0.4cm；Described air-permeable layer is by 30 parts of polyimides of mass parts, 5 parts of polycaprolactones, 19 parts of poly- breasts
Acid, 22 parts of o-formyl sodium benzenesulfonate contracting isonicotinoyl hydrazones and 13 parts of lignin fibres form, and the thickness of described air-permeable layer is
0.07cm.
7. a kind of OSA patient's nose cup as described in claim 3 or 4 or 6 it is characterised in that：Described rhinarium（2）It is provided with nose
Frame is expanded in chamber（4）, described nasal cavity expansion frame（4）It is made up of elastomeric material, described nasal cavity expands frame（4）Located at breather pipe（3）Outside, described
Nasal cavity expands frame（4）Front end is in circular arc, and elastic deformation outwards occurs, and described nasal cavity expands frame（4）Elastic deformation potential energy be 21 ~
27J.
8. as claimed in claim 7 a kind of OSA patient's nose cup it is characterised in that：Described appendix（7）Upper surface is covered with filter
Film（6）, described filter membrane by 22 parts of polyallyl acrylamide sodium of mass parts, 8 parts of activated carbons, 3 parts of ethyl hydroxy benzoates and 23 parts anhydrous
Calcium chloride forms, and the particle diameter of described anhydrous calcium chloride is less than 500 mesh, and the molecular formula of described polyallyl acrylamide sodium is
, described filter membrane（6）
With breather pipe（7）Connection.
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| US3726275A (en) * | 1971-12-14 | 1973-04-10 | I Jackson | Nasal cannulae |
| CN201524333U (en) * | 2009-10-27 | 2010-07-14 | 常文华 | Ventilating nose ball with support frame |
| CN103079624A (en) * | 2010-08-30 | 2013-05-01 | 皇家飞利浦电子股份有限公司 | Patient interface device with a frame assembly having a double-y supporting structure |
| TW201343213A (en) * | 2012-04-26 | 2013-11-01 | I & I Corp | Nose wing type nasal oxygen cannula |
| US20140360499A1 (en) * | 2013-06-09 | 2014-12-11 | Ronal Peets | Intranasal Airway Device |
| CN204275235U (en) * | 2014-12-01 | 2015-04-22 | 北京神鹿腾飞医疗科技有限公司 | CPAP nasal mask fixation kit |
| CN206414590U (en) * | 2016-09-14 | 2017-08-18 | 薛金凤 | A kind of OSA patient's nose cup |
-
2016
- 2016-09-14 CN CN201610825553.XA patent/CN106390261B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3726275A (en) * | 1971-12-14 | 1973-04-10 | I Jackson | Nasal cannulae |
| CN201524333U (en) * | 2009-10-27 | 2010-07-14 | 常文华 | Ventilating nose ball with support frame |
| CN103079624A (en) * | 2010-08-30 | 2013-05-01 | 皇家飞利浦电子股份有限公司 | Patient interface device with a frame assembly having a double-y supporting structure |
| TW201343213A (en) * | 2012-04-26 | 2013-11-01 | I & I Corp | Nose wing type nasal oxygen cannula |
| US20140360499A1 (en) * | 2013-06-09 | 2014-12-11 | Ronal Peets | Intranasal Airway Device |
| CN204275235U (en) * | 2014-12-01 | 2015-04-22 | 北京神鹿腾飞医疗科技有限公司 | CPAP nasal mask fixation kit |
| CN206414590U (en) * | 2016-09-14 | 2017-08-18 | 薛金凤 | A kind of OSA patient's nose cup |
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