CN106310235B - 一种兽药组合物及其制备方法和用途 - Google Patents
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Abstract
本发明提供了一种兽药组合物，它是由下述重量配比的原料制备而成：葡萄糖氧化酶400‑500份、芽孢杆菌200‑300份、半胱氨酸50‑100份、蛋氨酸50‑75份、谷胱甘肽100‑150份、硫辛酸10‑50份、维生素C 3‑10份、维生素E 0.5‑3.2份、蛋氨酸铬2‑15份、酵母硒1‑5份。本发明还提供了所述组合物的制备方法和用途。本发明的兽药组合物，各成分相互协同，在防治畜禽霉菌病和/或霉菌毒素中毒方面发挥了协同增效的作用，为临床提供了一种新的饲料添加剂及兽药选择。
Description
技术领域
本发明属于兽药领域，具体涉及一种兽药组合物及其制备方法和用途。
背景技术
霉菌是真菌的一种，霉菌毒素是霉菌产生的一种具有广泛化学结构的有毒次级代谢产物，霉菌毒素有很多种，如黄曲霉毒素、烟曲霉素、赭曲霉毒素、呕吐毒素、玉米赤霉烯酮等。近年来，由于霉菌毒素引发的问题越来越严重。在畜禽的饲养中，由于玉米赤霉烯酮侵害生殖系统导致母猪“假发情”、由于呕吐毒素侵害肠道系统导致的动物呕吐拒食、由于黄曲霉毒素侵害肝脏、肾脏损伤等常有发生。
饲料及饲料原料的霉变会引发霉菌毒素中毒，但目前人们对控制饲料霉变的重视程度仍较低。在饲料厂，习惯的方式仅是添加防霉剂来控制饲料的霉变。在养殖场，尤其在自配料的养殖场中，往往不注意添加防霉剂或采取其他措施控制霉菌。对于没有霉变的饲料原料及饲料，添加防霉剂可以起到预防霉变产生霉菌毒素的效果，而对动物喂食霉变饲料后，霉菌毒素对机体已造成的损害无法发挥作用。
因此，目前急需一种安全、有效的具有预防及解除霉菌毒素危害、修复受损机体作用的产品。
发明内容
本发明的目的在于提供一种兽药组合物及其制备方法和用途。
本发明提供了一种兽药组合物，它是由下述重量配比的原料制备而成：
葡萄糖氧化酶400-500份、芽孢杆菌200-300份、半胱氨酸50-100份、蛋氨酸50-75份、谷胱甘肽100-150份、硫辛酸10-50份、维生素C 3-10份、维生素E 0.5-3.2份、蛋氨酸铬2-15份、酵母硒1-5份。
其中，所述芽孢杆菌为枯草芽孢杆菌和/或地衣芽孢杆菌。
其中，它是由下述重量配比的原料制备而成：
葡萄糖氧化酶400-500份、枯草芽孢杆菌100-150份、地衣芽孢杆菌100-150份、半胱氨酸50-100份、蛋氨酸50-75份、谷胱甘肽100-150份、硫辛酸10-50份、维生素C 5-10份、维生素E 0.5-3.2份、蛋氨酸铬5-15份、酵母硒1-5份。
其中，它是由下述重量配比的原料制备而成：葡萄糖氧化酶500份、枯草芽孢杆菌100份、地衣芽孢杆菌100份、半胱氨酸85份、蛋氨酸65份、谷胱甘肽100份、硫辛酸40份、维生素C 3份，维生素E 3份，蛋氨酸铬2份，酵母硒2份。
其中，所述枯草芽孢杆菌、地衣芽孢杆菌，每g的活菌数为1000亿CUF。
本发明还提供了上述兽药组合物的制备方法，它包括如下步骤：
a、按重量配比称取原料；
b、将原料混合均匀，既得兽药组合物。
本发明还提供了上述兽药组合物在制备防治动物霉菌病和/或霉菌毒素中毒的饲料添加剂中的用途。
其中，所述动物为猪。
防治：预防和/或治疗。
动物霉菌病，是指动物感染一定数量的致病性霉菌而产生的相应病症，主要由霉变的饲料引起。
霉菌毒素中毒，是指动物采食了一定量被霉菌毒素污染的饲料而产生的相应病症，由霉菌毒素引起。
本发明还提供了上述兽药组合物在制备防治动物霉菌病和/或霉菌毒素中毒的饲料中的用途；其中，所述动物为猪。
本发明还提供了一种具有防治动物霉菌病和/或霉菌毒素中毒功效的动物饲料，其特征在于它是添加了上述兽药组合物的饲料。
本发明的兽药组合物，各成分相互协同，在防治畜禽霉菌病和/或霉菌毒素中毒方面发挥了协同增效的作用，显著提高了养殖业的经济价值；而且本发明组合物无毒副作用和残留，安全环保，为临床提供了一种新的饲料添加剂及兽药选择。
显然，根据本发明的上述内容，按照本领域的普通技术知识和惯用手段，在不脱离本发明上述基本技术思想前提下，还可以做出其它多种形式的修改、替换或变更。
以下通过实施例形式的具体实施方式，对本发明的上述内容再作进一步的详细说明。但不应将此理解为本发明上述主题的范围仅限于以下的实例。凡基于本发明上述内容所实现的技术均属于本发明的范围。
附图说明
图1为不同处理组饲喂轻度霉变商品饲料后的肝脏情况图。
图2为不同处理组饲喂轻度霉变商品饲料后的脾脏情况图。
图3为不同处理组饲喂轻度霉变商品饲料后的回盲瓣情况图。
具体实施方式
下面以实施例作进一步说明，但本发明不局限于这些实施例。
本发明所用的实验原料与试剂如下：
葡萄糖氧化酶购自上海宝曼生物科技有限公司，酶活性1000U/g；枯草芽孢杆菌和地衣芽孢杆菌由山东蔚蓝生物有限公司提供，活菌数均为1000亿CUF/g；蛋氨酸、谷胱甘肽、硫辛酸购自Sigma-Aldrich公司；维生素C3g和维生素E购自帝斯曼公司；蛋氨酸铬购自西亚试剂；酵母硒购自安琪酵母。
实施例1本发明兽药组合物的制备
步骤如下：
1、称取葡萄糖氧化酶500g，枯草芽孢杆菌100g，地衣芽孢杆菌100g，半胱氨酸85g，蛋氨酸65g，谷胱甘肽100g，硫辛酸40g，维生素C 3g，维生素E 3g，蛋氨酸铬2g，酵母硒2g。
2、将葡萄糖氧化酶、枯草芽孢杆菌、地衣芽孢杆菌、半胱氨酸、蛋氨酸、谷胱甘肽、硫辛酸、维生素C、维生素E、蛋氨酸铬、酵母硒混合均匀后，真空包装，即得本发明组合物1000g。
实施例2本发明兽药组合物的制备
1、称取葡萄糖氧化酶450g、枯草芽孢杆菌150g、地衣芽孢杆菌150g，半胱氨酸50g，蛋氨酸70g，谷胱甘肽125g，硫辛酸30g，维生素C 7g，维生素E 3g，蛋氨酸铬5g，酵母硒5g。
2、将葡萄糖氧化酶、枯草芽孢杆菌、地衣芽孢杆菌、半胱氨酸、蛋氨酸、谷胱甘肽、硫辛酸、维生素C、维生素E、蛋氨酸铬、酵母硒混合均匀后，真空包装，即得本发明组合物。
实施例3本发明兽药组合物的制备
1、称取葡萄糖氧化酶400g、枯草芽孢杆菌125g、地衣芽孢杆菌125g，半胱氨酸100g，蛋氨酸50g，谷胱甘肽150g，硫辛酸50g，维生素C 10g，维生素E 0.5g，蛋氨酸铬15g，酵母硒1g。
2、将葡萄糖氧化酶、枯草芽孢杆菌、地衣芽孢杆菌、半胱氨酸、蛋氨酸、谷胱甘肽、硫辛酸、维生素C、维生素E、蛋氨酸铬、酵母硒混合均匀后，真空包装，即得本发明组合物。
实施例4本发明兽药组合物的制备
1、称取葡萄糖氧化酶400g、枯草芽孢杆菌150g、地衣芽孢杆菌150g，半胱氨酸100g，蛋氨酸75g，谷胱甘肽150g，硫辛酸10g，维生素C 5g，维生素E 3.2g，蛋氨酸铬5g，酵母硒1g。
2、将葡萄糖氧化酶、枯草芽孢杆菌、地衣芽孢杆菌、半胱氨酸、蛋氨酸、谷胱甘肽、硫辛酸、维生素C、维生素E、蛋氨酸铬、酵母硒混合均匀后，真空包装，即得本发明组合物。
以下通过试验例具体说明本发明的有益效果：
试验例1本发明组合物用于预防霉菌毒素中毒、霉菌病
1、试验方法：
取110日龄育肥猪40头，随机分成两组，每组20头，全程饲喂轻度霉变商品饲料。一组饲料中添加实施例1制备的兽药组合物，添加量为100g/吨饲料(下称方案组)，另一组不添加作为对照组(下称对照组或未使用方案组)。饲喂45天，杀猪取猪内脏，观察猪肝脏、脾脏等器官损伤情况。
组合物添加量为100g/吨饲料：是指每吨饲料另外添加组合物100g。
2、试验结果：
结果见图1-3。
可见，对照组饲喂轻度霉变商品饲料后，猪的肝脏组织变性；脾脏肿大，末端梗死；回盲瓣呈纽扣状损害；使用本发明兽药组合组后，猪的肝脏、脾脏、回盲瓣正常，无病理变化。
本试验说明，本发明兽药组合物可以有效预防霉菌毒素中毒、预防霉菌病。
试验例2本发明组合物用于临床治疗霉菌毒素中毒
某猪场育肥小猪600多头，发病猪325头，约占50％，体重在60kg以上，转入生长舍1个半月左右，有28头小猪死亡。病猪精神沉郁，被毛粗乱枯燥无光，眼结膜充血潮红，严重者外翻，甚至遮挡眼球；咳嗽，呼吸加快；部分病猪耳朵及背部皮肤有突出的紫红小点，严重者布满全身；有呕吐现象，部分病猪出现拉稀，消瘦；约有10％的猪脱肛；一些病猪呈腹式呼吸，整栋猪采食量下降约40％，部分小母猪阴户红肿似发情，体温不高，粪便正常，经诊断为霉菌毒素中毒。
治疗方案：每吨饲料中添加实施例1制备的兽药组合物1kg，并在每吨饮水中添加葡萄糖2kg，维生素C 1kg，连续使用10天。同时进行全面消毒，降低环境中的病原微生物，防止其他疾病在猪抵抗力下降时侵入，引发猪群疫病暴发。
结果：经过上述治疗，仍有2头猪死，但饲喂5天后猪群停止发病和死亡，精神状态完好，10天后整个猪群恢复正常。
本试验说明，本发明兽药组合物可以有效治疗霉菌毒素中毒。
综上，本发明的兽药组合物，各成分相互协同，在防治畜禽霉菌病和/或霉菌毒素中毒方面发挥了协同增效的作用，为临床提供了一种新的饲料添加剂及兽药选择。
Claims (7)
1.一种兽药组合物，其特征在于，它是由下述重量配比的原料制备而成：
葡萄糖氧化酶500份、枯草芽孢杆菌100份、地衣芽孢杆菌100份、半胱氨酸85份、蛋氨酸65份、谷胱甘肽100份、硫辛酸40份、维生素C 3份，维生素E 3份，蛋氨酸铬2份，酵母硒2份。
2.根据权利要求1所述的兽药组合物，其特征在于，所述枯草芽孢杆菌、地衣芽孢杆菌，每g的活菌数为1000亿CUF。
3.权利要求1或2所述兽药组合物的制备方法，其特征在于，它包括如下步骤：
a、按重量配比称取原料；
b、将原料混合均匀，既得兽药组合物。
4.权利要求1或2所述兽药组合物在制备防治动物霉菌病和/或霉菌毒素中毒的饲料添加剂中的用途。
5.根据权利要求4所述的用途，其特征在于，所述动物为猪。
6.权利要求1或2所述兽药组合物在制备防治动物霉菌病和/或霉菌毒素中毒的饲料中的用途；其中，所述动物为猪。
7.一种具有防治动物霉菌病和/或霉菌毒素中毒功效的动物饲料，其特征在于，它是添加了权利要求1或2所述组合物的饲料。
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