CN106310223A - Compound capsule for treating acute pyogeniccholangitis and preparation method thereof - Google Patents

Compound capsule for treating acute pyogeniccholangitis and preparation method thereof Download PDF

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CN106310223A
CN106310223A CN201610997593.2A CN201610997593A CN106310223A CN 106310223 A CN106310223 A CN 106310223A CN 201610997593 A CN201610997593 A CN 201610997593A CN 106310223 A CN106310223 A CN 106310223A
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parts
herba
radix
powder
fructus
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陈腊保
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Nanjing Halls Biological Technology Co Ltd
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Nanjing Halls Biological Technology Co Ltd
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Abstract

The invention discloses a compound capsule for treating acute pyogeniccholangitis and a preparation method thereof. The ingredients of the compound capsule comprises the traditional Chinese medicine materials including homonoia riparia lour, pteris semipinnata, root or leaf of pilose triumfetta, small-fruited balloon vine fruit, bract, oriental grape root, centipede, fingered citron distillate, hemiptelea davidii bark, 40-80 parts of artemisia ordosica, dicranostigma leptopodum, abroma angusta, goldhair hedyotis herb, sedum amplibracteatum, belladonna, chaenomeles, polycarpae, ailanthus altissima, gray vernonia, tricalysia dubia, endothelium corneum gigeriae galli, bighead atractylodes rhizome, gall bladder, pericarpium citri reticulatae, polygala tenuifolia, dry hawthorn, clove, alpinia katsumadai, ginger processed pinellia, houttuynia cordata and cordyceps as well as western medicine ingredients including colistin sulfate, salicylic acid and doxycycline. The compound capsule can prevent nausea, vomit and diarrhea caused by the stimulation of doxycycline to gastrointestinal tract. The clinical application of the medicine is more safe and efficient.

Description

A kind of compound capsule treating acute pyogenic cholangitis and preparation method thereof
Technical field
The present invention relates to Chinese medicine and western medicine technical field, particularly to a kind of compound capsule treating acute pyogenic cholangitis and Its preparation method.
Background technology
Acute pyogenic cholangitis majority is secondary to calculus of bile duct and ascariasis of biliary tract, and these diseases cause bile duct obstruction, Cholestasis, thus secondary bacterial infection, pathogenic bacterium are mainly escherichia coli, Cray diphtheria, streptococcus faecalis and some anaerobe.
Acute pyogenic cholangitis onset is the most dangerous, is one of China's cholelithiasis patient's main causes of death.But, mesh Before the effective medicine of generally recognized as safe is still lacked for acute pyogenic cholangitis, it is therefore proposed that one treats acute suppuration Property cholangitis Chinese medicine and western medicine compound preparation, its raw material composition includes by weight, raw material of Chinese medicine: water vertebra wood 60-150 part, half Limit flag 45-90 parts, Radix Seu Folium Triumfettae Pilosae 100-200 part, Fructus Cardiospermi microcarpi 80-200 part, Herba Rednerved Chaydaiae 150-300 part, Radix Puerariae 100-250 part, mountain centipede 40-90 part, Liquor Fructus Citri sarcodactylis Distillata 20-50 part, Cortex Hemipteleae Davidii skin 90-150 part, Herba artemisiae ordosicae 30-100 Part, Herba Dicranostigmatis Leptopodi 50-150 part, high-spirited 80-120 part, Herba Hedyotidis Chrysotrichae 40-50 part, lamp-stand dish 30-60 part, Radix scopoliae carniolicoidis 10-25 part, underworld short, bristly hair or beard 50-100 part, Herba Polycarpaeae Corymbosae 40-80 part, Cortex Ailanthi 30-70 part, Herba Vernoniae Cinereae 60-100 part, Canis familiaris L. Bone bavin 40-110 part；Western medicine composition: COLISTIN SULFATE 2-5 part, salicylic acid 3-7 part, doxycycline 1-3.5 Part.But, the doxycycline in its western medicine composition has stimulation to gastrointestinal tract, shows as nausea,vomiting,diarrhea etc..
Summary of the invention
For solving the problems referred to above, the invention provides a kind of medicine for treating acute pyogenic cholangitis and preparation thereof Method, is prevented effectively from because gastrointestinal is stimulated by the doxycycline in western medicine composition, and occurs that Nausea and vomiting diarrhoea etc. is bad instead Should.
The present invention is the defect overcoming prior art, and the technical scheme provided is as follows:
A kind of compound capsule treating acute pyogenic cholangitis, by weight, its dispensing includes
Raw material of Chinese medicine: water vertebra wood 80-130 part, Herba Pteridis Semipinnatae 50-80 part, Radix Seu Folium Triumfettae Pilosae 100-180 part, Fructus Cardiospermi microcarpi 50-130 Part, Herba Rednerved Chaydaiae 180-280 part, Radix Puerariae 150-200 part, mountain centipede 50-80 part, Liquor Fructus Citri sarcodactylis Distillata 25-45 part, Cortex Hemipteleae Davidii skin 100-130 part, Herba artemisiae ordosicae 40-80 part, Herba Dicranostigmatis Leptopodi 60-120 part, high-spirited 85-105 part, Herba Hedyotidis Chrysotrichae 42-48 Part, lamp-stand dish 40-50 part, Radix scopoliae carniolicoidis 15-20 part, underworld short, bristly hair or beard 60-80 part, Herba Polycarpaeae Corymbosae 30-70 part, Cortex Ailanthi 20-60 Part, Herba Vernoniae Cinereae 45-85 part, Radix Tricalysiae dubiae 50-100 part, Endothelium Corneum Gigeriae Galli 70-90 part, Rhizoma Atractylodis Macrocephalae 70-90 part, Herba Elephantopi scaberis 50-70 part, Pericarpium Citri Reticulatae 40-50 part, Radix Polygalae 40-50 part, dry Fructus Crataegi 40-60 part, Flos Caryophylli 30-40 part, Semen Alpiniae Katsumadai 30-40 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5-50 part, Herba Houttuyniae 10-30 part, bubble ginseng 18-24 part；
Western medicine composition: COLISTIN SULFATE 6-8 part, salicylic acid 5-9 part, doxycycline 3-5 part.
Preferably, the compound capsule of described treatment acute pyogenic cholangitis, level by weight, its dispensing includes
Raw material of Chinese medicine: 105 parts of water vertebra wood, Herba Pteridis Semipinnatae 65 parts, Radix Seu Folium Triumfettae Pilosae 140 parts, Fructus Cardiospermi microcarpi 90 parts, Herba Rednerved Chaydaiae 230 Part, Radix Puerariae 175 parts, mountain centipede 65 parts, Liquor Fructus Citri sarcodactylis Distillata 35 parts, Cortex Hemipteleae Davidii skin 115 parts, Herba artemisiae ordosicae 60 parts, Herba Dicranostigmatis Leptopodi 90 parts, high-spirited 95 parts, Herba Hedyotidis Chrysotrichae 45 parts, lamp-stand dish 45 parts, Radix scopoliae carniolicoidis 18 parts, underworld short, bristly hair or beard 70 parts, sensual pleasure Grass 50 parts, Cortex Ailanthi 40 parts, Herba Vernoniae Cinereae 65 parts, Radix Tricalysiae dubiae 75 parts, Endothelium Corneum Gigeriae Galli 80 parts, the Rhizoma Atractylodis Macrocephalae 80 parts, Herba Elephantopi scaberis 60 parts, Pericarpium Citri Reticulatae 45 parts, Radix Polygalae 45 parts, dry Fructus Crataegi 50 parts, Flos Caryophylli 35 parts, Semen Alpiniae Katsumadai 35 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 23 parts, Herba Houttuyniae 20 parts, bubble ginseng 21 parts；
Western medicine composition: COLISTIN SULFATE 7 parts, salicylic acid 7 parts, doxycycline 4 parts.
Preferably, the compound capsule of described treatment acute pyogenic cholangitis, level by weight, its dispensing includes
Raw material of Chinese medicine: 80 parts of water vertebra wood, Herba Pteridis Semipinnatae 80 parts, Radix Seu Folium Triumfettae Pilosae 100 parts, Fructus Cardiospermi microcarpi 130 parts, Herba Rednerved Chaydaiae 180 Part, Radix Puerariae 200 parts, mountain centipede 50 parts, Liquor Fructus Citri sarcodactylis Distillata 45 parts, Cortex Hemipteleae Davidii skin 100 parts, Herba artemisiae ordosicae 80 parts, Herba Dicranostigmatis Leptopodi 60 parts, high-spirited 105 parts, Herba Hedyotidis Chrysotrichae 42 parts, lamp-stand dish 50 parts, Radix scopoliae carniolicoidis 15 parts, underworld short, bristly hair or beard 80 parts, sensual pleasure Grass 30 parts, Cortex Ailanthi 60 parts, Herba Vernoniae Cinereae 45 parts, Radix Tricalysiae dubiae 100 parts, Endothelium Corneum Gigeriae Galli 70 parts, the Rhizoma Atractylodis Macrocephalae 90 parts, Herba Elephantopi scaberis 50 Part, Pericarpium Citri Reticulatae 50 parts, Radix Polygalae 40 parts, dry Fructus Crataegi 60 parts, Flos Caryophylli 30 parts, Semen Alpiniae Katsumadai 40 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5 parts, Herba Houttuyniae 30 parts, bubble ginseng 18 parts；
Western medicine composition: COLISTIN SULFATE 6 parts, salicylic acid 9 parts, doxycycline 3 parts.
Preferably, the compound capsule of described treatment acute pyogenic cholangitis, level by weight, its dispensing includes
Raw material of Chinese medicine: 130 parts of water vertebra wood, Herba Pteridis Semipinnatae 50 parts, Radix Seu Folium Triumfettae Pilosae 180 parts, Fructus Cardiospermi microcarpi 50 parts, Herba Rednerved Chaydaiae 280 Part, Radix Puerariae 150 parts, mountain centipede 80 parts, Liquor Fructus Citri sarcodactylis Distillata 25 parts, Cortex Hemipteleae Davidii skin 130 parts, Herba artemisiae ordosicae 40 parts, Herba Dicranostigmatis Leptopodi 120 parts, high-spirited 85 parts, Herba Hedyotidis Chrysotrichae 48 parts, lamp-stand dish 40 parts, Radix scopoliae carniolicoidis 20 parts, underworld short, bristly hair or beard 60 parts, sensual pleasure Grass 70 parts, Cortex Ailanthi 20 parts, Herba Vernoniae Cinereae 85 parts, Radix Tricalysiae dubiae 50 parts, Endothelium Corneum Gigeriae Galli 90 parts, the Rhizoma Atractylodis Macrocephalae 70 parts, Herba Elephantopi scaberis 70 Part, Pericarpium Citri Reticulatae 40 parts, Radix Polygalae 50 parts, dry Fructus Crataegi 40 parts, Flos Caryophylli 40 parts, Semen Alpiniae Katsumadai 30 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50 parts, Herba Houttuyniae 10 parts, bubble Join 24 parts；
Western medicine composition: COLISTIN SULFATE 8 parts, salicylic acid 5 parts, doxycycline 5 parts.
The preparation method of the compound capsule of described treatment acute pyogenic cholangitis, comprises the steps:
Step 1: by water vertebra wood, Herba Pteridis Semipinnatae, Radix Seu Folium Triumfettae Pilosae, Fructus Cardiospermi microcarpi, Herba Rednerved Chaydaiae, Radix Puerariae, mountain centipede, Cortex Hemipteleae Davidii skin, Herba artemisiae ordosicae, Herba Dicranostigmatis Leptopodi, high-spirited, Herba Hedyotidis Chrysotrichae, lamp-stand dish, Radix scopoliae carniolicoidis, underworld short, bristly hair or beard, Herba Polycarpaeae Corymbosae, Herba Vernoniae Cinereae, Radix Tricalysiae dubiae, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Mix homogeneously after Radix Polygalae, Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, the pulverizing respectively of bubble ginseng, adds alcohol reflux, obtains first Extracting solution and the first medicinal residues, carry out the first extracting solution decompression distillation and obtain the first unguentum, and vacuum decompression is dried, and grinds to form thin Powder, obtains the first powder；
Step 2: the first medicinal residues are added 6-8 times of weight distilled water, is placed in decocting medicine pot, cold filtration after suffering 5-7h, obtains the Two extracting solution and the second medicinal residues, add 3-5 times of weight distilled water, cold filtration after suffering 3-5h in the second medicinal residues, obtains Three extracting solution, mix the second extracting solution and the 3rd extracting solution, carry out distillation and concentration, obtain concentrated solution, and decompression is distilled off Distilled water, obtains the second unguentum, and the second unguentum vacuum decompression grinds to form fine powder after drying, obtains the second powder；
Step 3: Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi grind to form mix homogeneously after fine powder respectively, obtain the 3rd powder；
Step 4: by the first powder, the second powder and the 3rd powder mix homogeneously, with aerosol apparatus, Liquor Fructus Citri sarcodactylis Distillata is uniformly sprayed onto Face, i.e. obtains raw material of Chinese medicine extract.
Step 5: gained raw material of Chinese medicine extract is mixed homogeneously with COLISTIN SULFATE, salicylic acid, doxycycline, so After add adjuvant mix homogeneously according to a conventional method, load in capsule shells, make capsule.
The medicine of the new Integrated TCM that the present invention provides, formula advantages of simple, curative effect are good, can either effectively treat Acute pyogenic cholangitis, is avoided that again and produces nausea,vomiting,diarrhea etc. because doxycycline stimulates gastrointestinal, make medicine The clinical practice of thing is more safe and effective.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further.
Embodiment 1
A kind of compound capsule treating acute pyogenic cholangitis, by weight, its dispensing includes
Raw material of Chinese medicine: 105 parts of water vertebra wood, Herba Pteridis Semipinnatae 65 parts, Radix Seu Folium Triumfettae Pilosae 140 parts, Fructus Cardiospermi microcarpi 90 parts, Herba Rednerved Chaydaiae 230 Part, Radix Puerariae 175 parts, mountain centipede 65 parts, Liquor Fructus Citri sarcodactylis Distillata 35 parts, Cortex Hemipteleae Davidii skin 115 parts, Herba artemisiae ordosicae 60 parts, Herba Dicranostigmatis Leptopodi 90 parts, high-spirited 95 parts, Herba Hedyotidis Chrysotrichae 45 parts, lamp-stand dish 45 parts, Radix scopoliae carniolicoidis 18 parts, underworld short, bristly hair or beard 70 parts, sensual pleasure Grass 50 parts, Cortex Ailanthi 40 parts, Herba Vernoniae Cinereae 65 parts, Radix Tricalysiae dubiae 75 parts, Endothelium Corneum Gigeriae Galli 80 parts, the Rhizoma Atractylodis Macrocephalae 80 parts, Herba Elephantopi scaberis 60 parts, Pericarpium Citri Reticulatae 45 parts, Radix Polygalae 45 parts, dry Fructus Crataegi 50 parts, Flos Caryophylli 35 parts, Semen Alpiniae Katsumadai 35 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 23 parts, Herba Houttuyniae 20 parts, bubble ginseng 21 parts；
Western medicine composition: COLISTIN SULFATE 7 parts, salicylic acid 7 parts, doxycycline 4 parts.
The preparation method of the compound capsule of described treatment acute pyogenic cholangitis, comprises the steps:
Step 1: by water vertebra wood, Herba Pteridis Semipinnatae, Radix Seu Folium Triumfettae Pilosae, Fructus Cardiospermi microcarpi, Herba Rednerved Chaydaiae, Radix Puerariae, mountain centipede, Cortex Hemipteleae Davidii skin, Herba artemisiae ordosicae, Herba Dicranostigmatis Leptopodi, high-spirited, Herba Hedyotidis Chrysotrichae, lamp-stand dish, Radix scopoliae carniolicoidis, underworld short, bristly hair or beard, Herba Polycarpaeae Corymbosae, Herba Vernoniae Cinereae, Radix Tricalysiae dubiae, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Mix homogeneously after Radix Polygalae, Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, the pulverizing respectively of bubble ginseng, adds alcohol reflux, obtains first Extracting solution and the first medicinal residues, carry out the first extracting solution decompression distillation and obtain the first unguentum, and vacuum decompression is dried, and grinds to form thin Powder, obtains the first powder；
Step 2: the first medicinal residues are added 7 times of weight distilled water, is placed in decocting medicine pot, cold filtration after suffering 6h, obtains second and carry Take liquid and the second medicinal residues, the second medicinal residues add 4 times of weight distilled water, cold filtration after suffering 4h, obtains the 3rd extracting solution, Second extracting solution and the 3rd extracting solution being mixed, carry out distillation and concentration, obtain concentrated solution, decompression is distilled off distilled water, obtains Second unguentum, the second unguentum vacuum decompression grinds to form fine powder after drying, obtains the second powder；
Step 3: Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi grind to form mix homogeneously after fine powder respectively, obtain the 3rd powder；
Step 4: by the first powder, the second powder and the 3rd powder mix homogeneously, with aerosol apparatus, Liquor Fructus Citri sarcodactylis Distillata is uniformly sprayed onto Face, i.e. obtains raw material of Chinese medicine extract.
Step 5: gained raw material of Chinese medicine extract is mixed homogeneously with COLISTIN SULFATE, salicylic acid, doxycycline, so After add adjuvant mix homogeneously according to a conventional method, load in capsule shells, make capsule.
Embodiment 2
A kind of compound capsule treating acute pyogenic cholangitis, by weight, its dispensing includes
Raw material of Chinese medicine: 80 parts of water vertebra wood, Herba Pteridis Semipinnatae 80 parts, Radix Seu Folium Triumfettae Pilosae 100 parts, Fructus Cardiospermi microcarpi 130 parts, Herba Rednerved Chaydaiae 180 Part, Radix Puerariae 200 parts, mountain centipede 50 parts, Liquor Fructus Citri sarcodactylis Distillata 45 parts, Cortex Hemipteleae Davidii skin 100 parts, Herba artemisiae ordosicae 80 parts, Herba Dicranostigmatis Leptopodi 60 parts, high-spirited 105 parts, Herba Hedyotidis Chrysotrichae 42 parts, lamp-stand dish 50 parts, Radix scopoliae carniolicoidis 15 parts, underworld short, bristly hair or beard 80 parts, sensual pleasure Grass 30 parts, Cortex Ailanthi 60 parts, Herba Vernoniae Cinereae 45 parts, Radix Tricalysiae dubiae 100 parts, Endothelium Corneum Gigeriae Galli 70 parts, the Rhizoma Atractylodis Macrocephalae 90 parts, Herba Elephantopi scaberis 50 Part, Pericarpium Citri Reticulatae 50 parts, Radix Polygalae 40 parts, dry Fructus Crataegi 60 parts, Flos Caryophylli 30 parts, Semen Alpiniae Katsumadai 40 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5 parts, Herba Houttuyniae 30 parts, bubble ginseng 18 parts；
Western medicine composition: COLISTIN SULFATE 6 parts, salicylic acid 9 parts, doxycycline 3 parts.
Preferably, the compound capsule of described treatment acute pyogenic cholangitis, level by weight, its dispensing includes
Raw material of Chinese medicine: 130 parts of water vertebra wood, Herba Pteridis Semipinnatae 50 parts, Radix Seu Folium Triumfettae Pilosae 180 parts, Fructus Cardiospermi microcarpi 50 parts, Herba Rednerved Chaydaiae 280 Part, Radix Puerariae 150 parts, mountain centipede 80 parts, Liquor Fructus Citri sarcodactylis Distillata 25 parts, Cortex Hemipteleae Davidii skin 130 parts, Herba artemisiae ordosicae 40 parts, Herba Dicranostigmatis Leptopodi 120 parts, high-spirited 85 parts, Herba Hedyotidis Chrysotrichae 48 parts, lamp-stand dish 40 parts, Radix scopoliae carniolicoidis 20 parts, underworld short, bristly hair or beard 60 parts, sensual pleasure Grass 70 parts, Cortex Ailanthi 20 parts, Herba Vernoniae Cinereae 85 parts, Radix Tricalysiae dubiae 50 parts, Endothelium Corneum Gigeriae Galli 90 parts, the Rhizoma Atractylodis Macrocephalae 70 parts, Herba Elephantopi scaberis 70 Part, Pericarpium Citri Reticulatae 40 parts, Radix Polygalae 50 parts, dry Fructus Crataegi 40 parts, Flos Caryophylli 40 parts, Semen Alpiniae Katsumadai 30 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50 parts, Herba Houttuyniae 10 parts, bubble Join 24 parts；
Western medicine composition: COLISTIN SULFATE 8 parts, salicylic acid 5 parts, doxycycline 5 parts.
The preparation method of the compound capsule of described treatment acute pyogenic cholangitis, comprises the steps:
Step 1: by water vertebra wood, Herba Pteridis Semipinnatae, Radix Seu Folium Triumfettae Pilosae, Fructus Cardiospermi microcarpi, Herba Rednerved Chaydaiae, Radix Puerariae, mountain centipede, Cortex Hemipteleae Davidii skin, Herba artemisiae ordosicae, Herba Dicranostigmatis Leptopodi, high-spirited, Herba Hedyotidis Chrysotrichae, lamp-stand dish, Radix scopoliae carniolicoidis, underworld short, bristly hair or beard, Herba Polycarpaeae Corymbosae, Herba Vernoniae Cinereae, Radix Tricalysiae dubiae, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Mix homogeneously after Radix Polygalae, Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, the pulverizing respectively of bubble ginseng, adds alcohol reflux, obtains first Extracting solution and the first medicinal residues, carry out the first extracting solution decompression distillation and obtain the first unguentum, and vacuum decompression is dried, and grinds to form thin Powder, obtains the first powder；
Step 2: the first medicinal residues are added 6 times of weight distilled water, is placed in decocting medicine pot, cold filtration after suffering 7h, obtains second and carry Take liquid and the second medicinal residues, the second medicinal residues add 5 times of weight distilled water, cold filtration after suffering 3h, obtains the 3rd extracting solution, Second extracting solution and the 3rd extracting solution being mixed, carry out distillation and concentration, obtain concentrated solution, decompression is distilled off distilled water, obtains Second unguentum, the second unguentum vacuum decompression grinds to form fine powder after drying, obtains the second powder；
Step 3: Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi grind to form mix homogeneously after fine powder respectively, obtain the 3rd powder；
Step 4: by the first powder, the second powder and the 3rd powder mix homogeneously, with aerosol apparatus, Liquor Fructus Citri sarcodactylis Distillata is uniformly sprayed onto Face, i.e. obtains raw material of Chinese medicine extract.
Step 5: gained raw material of Chinese medicine extract is mixed homogeneously with COLISTIN SULFATE, salicylic acid, doxycycline, so After add adjuvant mix homogeneously according to a conventional method, load in capsule shells, make capsule.
Embodiment 3
A kind of compound capsule treating acute pyogenic cholangitis, by weight, its dispensing includes
Raw material of Chinese medicine: 130 parts of water vertebra wood, Herba Pteridis Semipinnatae 50 parts, Radix Seu Folium Triumfettae Pilosae 180 parts, Fructus Cardiospermi microcarpi 50 parts, Herba Rednerved Chaydaiae 280 Part, Radix Puerariae 150 parts, mountain centipede 80 parts, Liquor Fructus Citri sarcodactylis Distillata 25 parts, Cortex Hemipteleae Davidii skin 130 parts, Herba artemisiae ordosicae 40 parts, Herba Dicranostigmatis Leptopodi 120 parts, high-spirited 85 parts, Herba Hedyotidis Chrysotrichae 48 parts, lamp-stand dish 40 parts, Radix scopoliae carniolicoidis 20 parts, underworld short, bristly hair or beard 60 parts, sensual pleasure Grass 70 parts, Cortex Ailanthi 20 parts, Herba Vernoniae Cinereae 85 parts, Radix Tricalysiae dubiae 50 parts, Endothelium Corneum Gigeriae Galli 90 parts, the Rhizoma Atractylodis Macrocephalae 70 parts, Herba Elephantopi scaberis 70 Part, Pericarpium Citri Reticulatae 40 parts, Radix Polygalae 50 parts, dry Fructus Crataegi 40 parts, Flos Caryophylli 40 parts, Semen Alpiniae Katsumadai 30 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50 parts, Herba Houttuyniae 10 parts, bubble Join 24 parts；
Western medicine composition: COLISTIN SULFATE 8 parts, salicylic acid 5 parts, doxycycline 5 parts.
The preparation method of the compound capsule of described treatment acute pyogenic cholangitis, comprises the steps:
Step 1: by water vertebra wood, Herba Pteridis Semipinnatae, Radix Seu Folium Triumfettae Pilosae, Fructus Cardiospermi microcarpi, Herba Rednerved Chaydaiae, Radix Puerariae, mountain centipede, Cortex Hemipteleae Davidii skin, Herba artemisiae ordosicae, Herba Dicranostigmatis Leptopodi, high-spirited, Herba Hedyotidis Chrysotrichae, lamp-stand dish, Radix scopoliae carniolicoidis, underworld short, bristly hair or beard, Herba Polycarpaeae Corymbosae, Herba Vernoniae Cinereae, Radix Tricalysiae dubiae, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Mix homogeneously after Radix Polygalae, Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, the pulverizing respectively of bubble ginseng, adds alcohol reflux, obtains first Extracting solution and the first medicinal residues, carry out the first extracting solution decompression distillation and obtain the first unguentum, and vacuum decompression is dried, and grinds to form thin Powder, obtains the first powder；
Step 2: the first medicinal residues are added 8 times of weight distilled water, is placed in decocting medicine pot, cold filtration after suffering 5h, obtains second and carry Take liquid and the second medicinal residues, the second medicinal residues add 3 times of weight distilled water, cold filtration after suffering 5h, obtains the 3rd extracting solution, Second extracting solution and the 3rd extracting solution being mixed, carry out distillation and concentration, obtain concentrated solution, decompression is distilled off distilled water, obtains Second unguentum, the second unguentum vacuum decompression grinds to form fine powder after drying, obtains the second powder；
Step 3: Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi grind to form mix homogeneously after fine powder respectively, obtain the 3rd powder；
Step 4: by the first powder, the second powder and the 3rd powder mix homogeneously, with aerosol apparatus, Liquor Fructus Citri sarcodactylis Distillata is uniformly sprayed onto Face, i.e. obtains raw material of Chinese medicine extract.
Step 5: gained raw material of Chinese medicine extract is mixed homogeneously with COLISTIN SULFATE, salicylic acid, doxycycline, so After add adjuvant mix homogeneously according to a conventional method, load in capsule shells, make capsule.
Medicine that embodiment 1-3 prepares and be the medicine of prior art as a control group, identical agent pressed by every kind of medicine Amount is respectively used to 100 example clinical patient medications, and the statistics after medication two weeks is as follows:
Medicine Matched group Embodiment 1 Embodiment 2 Embodiment 3
Gastrointestinal upset 18 examples 1 example 1 example 0 example
Proportion 18% 0% 1% 0%
Visible, obtained by the present invention for treating the medicine of acute pyogenic cholangitis, for Integrated TCM formula, by letter Prepared by single preparation technology, can either effectively treat acute pyogenic cholangitis, be avoided that again because doxycycline is to gastrointestinal Stimulating and produce nausea,vomiting,diarrhea etc., the clinical practice making medicine is more safe and effective.
Additionally, by the improvement of comminution by gas stream machine base in preparation process of the present invention, it is possible to effectively reduce air-flow Shake during pulverizer work, improves medicine preparation efficiency.
In the way of embodiment illustrates, the present invention is described above, it will be understood by those of skill in the art that these public affairs Open and be not limited to embodiments described above, in the case of without departing from the scope of the present invention, can make a variety of changes, change and Replace.

Claims (5)

1. the compound capsule treating acute pyogenic cholangitis, it is characterised in that by weight, its dispensing includes
Raw material of Chinese medicine: water vertebra wood 80-130 part, Herba Pteridis Semipinnatae 50-80 part, Radix Seu Folium Triumfettae Pilosae 100-180 part, Fructus Cardiospermi microcarpi 50-130 part, bract Wood 180-280 part, Radix Puerariae 150-200 part, mountain centipede 50-80 part, Liquor Fructus Citri sarcodactylis Distillata 25-45 part, Cortex Hemipteleae Davidii skin 100-130 part, black sand Artemisia 40-80 part, Herba Dicranostigmatis Leptopodi 60-120 part, high-spirited 85-105 part, Herba Hedyotidis Chrysotrichae 42-48 part, lamp-stand dish 40-50 part, Radix scopoliae carniolicoidis 15-20 part, underworld short, bristly hair or beard 60-80 part, Herba Polycarpaeae Corymbosae 30-70 part, Cortex Ailanthi 20-60 part, Herba Vernoniae Cinereae 45-85 part, Radix Tricalysiae dubiae 50-100 part, Endothelium Corneum Gigeriae Galli 70-90 part, Rhizoma Atractylodis Macrocephalae 70-90 part, Herba Elephantopi scaberis 50-70 part, Pericarpium Citri Reticulatae 40-50 part, Radix Polygalae 40-50 part, dry Fructus Crataegi 40-60 Part, Flos Caryophylli 30-40 part, Semen Alpiniae Katsumadai 30-40 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5-50 part, Herba Houttuyniae 10-30 part, bubble ginseng 18-24 part；
Western medicine composition: COLISTIN SULFATE 6-8 part, salicylic acid 5-9 part, doxycycline 3-5 part.
2. the compound capsule treating acute pyogenic cholangitis as claimed in claim 1, it is characterised in that by weight, it Dispensing include
Raw material of Chinese medicine: 105 parts of water vertebra wood, Herba Pteridis Semipinnatae 65 parts, Radix Seu Folium Triumfettae Pilosae 140 parts, Fructus Cardiospermi microcarpi 90 parts, Herba Rednerved Chaydaiae 230 parts, Radix Puerariae 175 parts, mountain centipede 65 parts, Liquor Fructus Citri sarcodactylis Distillata 35 parts, Cortex Hemipteleae Davidii skin 115 parts, Herba artemisiae ordosicae 60 parts, Herba Dicranostigmatis Leptopodi 90 parts, high-spirited 95 parts, yellow hair Auricled Hedyotis Herb 45 parts, lamp-stand dish 45 parts, Radix scopoliae carniolicoidis 18 parts, underworld short, bristly hair or beard 70 parts, Herba Polycarpaeae Corymbosae 50 parts, Cortex Ailanthi 40 parts, Herba Vernoniae Cinereae 65 parts, Os Canitis Bavin 75 parts, Endothelium Corneum Gigeriae Galli 80 parts, the Rhizoma Atractylodis Macrocephalae 80 parts, Herba Elephantopi scaberis 60 parts, Pericarpium Citri Reticulatae 45 parts, Radix Polygalae 45 parts, dry Fructus Crataegi 50 parts, Flos Caryophylli 35 parts, Semen Alpiniae Katsumadai 35 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 23 parts, Herba Houttuyniae 20 parts, bubble ginseng 21 parts；
Western medicine composition: COLISTIN SULFATE 7 parts, salicylic acid 7 parts, doxycycline 4 parts.
3. the compound capsule treating acute pyogenic cholangitis as claimed in claim 1, it is characterised in that by weight, it Dispensing include
Raw material of Chinese medicine: 80 parts of water vertebra wood, Herba Pteridis Semipinnatae 80 parts, Radix Seu Folium Triumfettae Pilosae 100 parts, Fructus Cardiospermi microcarpi 130 parts, Herba Rednerved Chaydaiae 180 parts, Radix Puerariae 200 parts, mountain centipede 50 parts, Liquor Fructus Citri sarcodactylis Distillata 45 parts, Cortex Hemipteleae Davidii skin 100 parts, Herba artemisiae ordosicae 80 parts, Herba Dicranostigmatis Leptopodi 60 parts, high-spirited 105 parts, yellow Hair Auricled Hedyotis Herb 42 parts, lamp-stand dish 50 parts, Radix scopoliae carniolicoidis 15 parts, underworld short, bristly hair or beard 80 parts, Herba Polycarpaeae Corymbosae 30 parts, Cortex Ailanthi 60 parts, Herba Vernoniae Cinereae 45 parts, Canis familiaris L. Bone bavin 100 parts, Endothelium Corneum Gigeriae Galli 70 parts, the Rhizoma Atractylodis Macrocephalae 90 parts, Herba Elephantopi scaberis 50 parts, Pericarpium Citri Reticulatae 50 parts, Radix Polygalae 40 parts, dry Fructus Crataegi 60 parts, Flos Caryophylli 30 Part, Semen Alpiniae Katsumadai 40 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5 parts, Herba Houttuyniae 30 parts, bubble ginseng 18 parts；
Western medicine composition: COLISTIN SULFATE 6 parts, salicylic acid 9 parts, doxycycline 3 parts.
4. the compound capsule treating acute pyogenic cholangitis as claimed in claim 1, it is characterised in that by weight, it Dispensing include
Raw material of Chinese medicine: 130 parts of water vertebra wood, Herba Pteridis Semipinnatae 50 parts, Radix Seu Folium Triumfettae Pilosae 180 parts, Fructus Cardiospermi microcarpi 50 parts, Herba Rednerved Chaydaiae 280 parts, Radix Puerariae 150 parts, mountain centipede 80 parts, Liquor Fructus Citri sarcodactylis Distillata 25 parts, Cortex Hemipteleae Davidii skin 130 parts, Herba artemisiae ordosicae 40 parts, Herba Dicranostigmatis Leptopodi 120 parts, high-spirited 85 parts, yellow Hair Auricled Hedyotis Herb 48 parts, lamp-stand dish 40 parts, Radix scopoliae carniolicoidis 20 parts, underworld short, bristly hair or beard 60 parts, Herba Polycarpaeae Corymbosae 70 parts, Cortex Ailanthi 20 parts, Herba Vernoniae Cinereae 85 parts, Canis familiaris L. Bone bavin 50 parts, Endothelium Corneum Gigeriae Galli 90 parts, the Rhizoma Atractylodis Macrocephalae 70 parts, Herba Elephantopi scaberis 70 parts, Pericarpium Citri Reticulatae 40 parts, Radix Polygalae 50 parts, dry Fructus Crataegi 40 parts, Flos Caryophylli 40 Part, Semen Alpiniae Katsumadai 30 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 50 parts, Herba Houttuyniae 10 parts, bubble ginseng 24 parts；
Western medicine composition: COLISTIN SULFATE 8 parts, salicylic acid 5 parts, doxycycline 5 parts.
5. the preparation method of the compound capsule of the treatment acute pyogenic cholangitis as described in any one of claim 1-3, it is special Levy and be, comprise the steps:
Step 1: by water vertebra wood, Herba Pteridis Semipinnatae, Radix Seu Folium Triumfettae Pilosae, Fructus Cardiospermi microcarpi, Herba Rednerved Chaydaiae, Radix Puerariae, mountain centipede, Cortex Hemipteleae Davidii skin, Herba artemisiae ordosicae, bald Skin ulcer flower, high-spirited, Herba Hedyotidis Chrysotrichae, lamp-stand dish, Radix scopoliae carniolicoidis, underworld short, bristly hair or beard, Herba Polycarpaeae Corymbosae, Herba Vernoniae Cinereae, Radix Tricalysiae dubiae, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Polygalae, Mix homogeneously after Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, the pulverizing respectively of bubble ginseng, adds alcohol reflux, obtains the first extraction Liquid and the first medicinal residues, carry out the first extracting solution decompression distillation and obtain the first unguentum, and vacuum decompression is dried, and grinds to form fine powder, First powder；
Step 2: the first medicinal residues are added 6-8 times of weight distilled water, is placed in decocting medicine pot, cold filtration after suffering 5-7h, obtains the Two extracting solution and the second medicinal residues, add 3-5 times of weight distilled water, cold filtration after suffering 3-5h in the second medicinal residues, obtains Three extracting solution, mix the second extracting solution and the 3rd extracting solution, carry out distillation and concentration, obtain concentrated solution, and decompression is distilled off Distilled water, obtains the second unguentum, and the second unguentum vacuum decompression grinds to form fine powder after drying, obtains the second powder；
Step 3: Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi grind to form mix homogeneously after fine powder respectively, obtain the 3rd powder；
Step 4: by the first powder, the second powder and the 3rd powder mix homogeneously, with aerosol apparatus, Liquor Fructus Citri sarcodactylis Distillata is uniformly sprayed onto Face, i.e. obtains raw material of Chinese medicine extract.
Step 5: gained raw material of Chinese medicine extract is mixed homogeneously with COLISTIN SULFATE, salicylic acid, doxycycline, then presses Conventional method adds adjuvant mix homogeneously, loads in capsule shells, makes capsule.
CN201610997593.2A 2016-11-14 2016-11-14 Compound capsule for treating acute pyogeniccholangitis and preparation method thereof Pending CN106310223A (en)

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