CN106309915A - Decoction pharmaceutical for treating systematic scleroderma - Google Patents

Decoction pharmaceutical for treating systematic scleroderma Download PDF

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Publication number
CN106309915A
CN106309915A CN201610820016.6A CN201610820016A CN106309915A CN 106309915 A CN106309915 A CN 106309915A CN 201610820016 A CN201610820016 A CN 201610820016A CN 106309915 A CN106309915 A CN 106309915A
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medicine
decoction
system type
gram
treatment
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孙再坤
赵魁华
马翔星
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/09Lichens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
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  • Biotechnology (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a traditional Chinese medicine preparation, in particular to a decoction pharmaceutical for treating systematic scleroderma, made from 40-50 g of Radix Fici Beecheyanae, 13-15 g of each of Rhizoma Polygonati Cirrhifolii and Amaranthus caudatus root, 8-10 g of each of Filum Alectoria Asiatica and Fructus Mori, and 15-20 ml of 60 ABV baijiu. The decoction pharmaceutical has the advantages that the formulation is novel, the cost is low and the therapeutic effect is good.

Description

One treats the sclerodermatous decoction medicine of system type
Technical field:
The present invention relates to a kind of Chinese medicine preparation, be specifically related to one and treat the sclerodermatous decoction medicine of system type.
Background technology:
Scleroderma is a kind of disease betiding skin surface, and the reason caused is many and autoimmune function is lacked of proper care, meridians It is obstructed or QI-blood circulation is the most relevant.System type scleroderma refers to have influence on the acra skin sclerosis of human body viscera and face Property disease, its Symptoms is: originally acra feel cold, pale or livid purple and have substantive edema, skin is the hardest soon, it is impossible to pinch Rising, there is waxy gloss on surface, and with pigmentation, and then atrophoderma is thinning, subcutaneous tissue and muscle become hardening, are close to bone Bone, forms hardwood tabular etc..At present, the sclerodermatous medicine of state's internal therapy system type is few, mainly based on Western medicine, there is treatment The shortcomings such as costly, toxic and side effects is big, therapeutic effect is satisfied not.The sclerodermatous medicine of Chinese traditional treatment system type is less, especially It is on treatment thoughts and Therapeutic Method, excessively lay particular stress on softening the hard mass granulation promoting, and have ignored comprehensive improvement the five internal organs and promoting flow of QI and blood, make patient dirty Internal organs function can not get returning unit and poor blood circulation, causes medicine the best to the therapeutic effect of this disease.
Summary of the invention:
It is an object of the invention to use the weak point existing for medicine for treatment system type scleroderma at present, and provide One treats the sclerodermatous decoction medicine of system type.
The technical scheme is that and be achieved in that:
One treats the sclerodermatous decoction medicine of system type, and this medicine is made up of following raw material: Radix Fici beecheyanae 40-50 Gram, each 13-15 gram of Rhizoma Polygonati Cirrhifolii, Radix Amaranthi Caudati, each 8-10 gram of Alectoria asiatica Du Rietz, Fructus Lycii, 60 ° of Chinese liquor 15-20 milliliters.
One treats the sclerodermatous decoction medicine of system type, and the preparation method of this medicine is: first by before above-mentioned raw material of Chinese medicine Four taste choppings, put in decocting container together with Fructus Lycii, add water to exceed powder 4-5cm and be advisable, and then heating decocts 20 minutes Stop, removing slag and take medicine of a warm nature juice, finally pour Chinese liquor and stir evenly.
One treats the sclerodermatous decoction medicine of system type, and this drug ratio raw material feeding is easy, cheap, it is possible to decrease Medicine cost, alleviates patient economy burden.
One treats the sclerodermatous decoction medicine of system type, the form of administration of this medicine, be several suitably can preparation type Middle Orally-administered decoction dosage form after numerous experiments and selected by with emphasis health giving quality as preference, its object is to: one is system Standby simple, taking convenience;Two is that decoction decoction being taken warmly drug osmotic speed is fast;Three is the absorbed effect of effective active composition in medicine Good.Selecting agent experimental selection preliminary election dosage form is two kinds, and one is in the case of this programme proportioning raw materials is identical, by Chinese medicine routine side Method is respectively prepared Orally-administered decoction and Chinese liquor mediation two kinds of different dosing dosage forms of powder externally dressing, within 15 days, is a course for the treatment of with medication, Experimental data statistics after two course of therapy is:
Clinical medicine dosage form Case load Recovery from illness Take a turn for the better Invalid Effective percentage
Orally-administered decoction 3 2 1 0 100%
Mediation externally dressing 3 0 2 1 67%
One treats the sclerodermatous decoction medicine of system type, and this medicine have employed solid material in preparation and application The method that pan-fried juice and Chinese liquor are taken after mixing it with water.Traditional decoction the most all uses directly decocts juice instructions of taking, this method exist the most very much not Foot is exactly the easy drain evaporation of wine liquid, and medicine gesture is obstructed, impact effect.
One treats the sclerodermatous decoction medicine of system type, and this medicine, in overall technical architecture forming process, is carried out Different material combination and three comparative tests of the produced curative effect of different component proportioning.Test one, with Catechu, Radix Curcumae, blood Exhaust, Cortex Mori, Radix Rubiae are the conventional combination side that raw material is constituted by corresponding proportioning amounts of components, use decoction medicine treatment system Type scleroderma, its curative effect, compared with this programme, reduces about 26% than this programme effective percentage;Test two, at this programme raw material In proportioning, remove Radix Fici beecheyanae and two kinds of raw materials of Chinese liquor, with Rhizoma Polygonati Cirrhifolii, Radix Amaranthi Caudati, Alectoria asiatica Du Rietz, Fructus Lycii for raw material by corresponding Proportioning amounts of components is combination side, uses decoction medicine treatment system type scleroderma, and its curative effect is compared with this programme, than we Case effective percentage reduces about 12%;Test three, in this programme proportioning raw materials, is reduced to 20-by the amounts of components of Radix Fici beecheyanae The conventional amount used of 25 grams, in the case of other raw material components consumption is constant, uses Orally-administered decoction to carry out system type scleroderma Treatment, its curative effect, compared with this programme, only accounts for this programme efficient about 75%.
One treats the sclerodermatous decoction medicine of system type, and its treatment thoughts is based on tracking the five internal organs, takes into account circulation of qi promoting and lives Blood, with change the traditional Chinese medical science common based on the treatment thoughts of softening the hard mass granulation promoting and Therapeutic Method.The traditional Chinese medical science is thought, upper limb is both hands, warp Arteries and veins is connected with the heart, lung;Lower limb are biped, and passages through which vital energy circulates is come round with spleen, liver, kidney.The root of acra pathological changes at the five internal organs, only comprehensively regulating The five internal organs, allow it recover normal function, except acroscleroderma can realize.In medicine, Radix Fici beecheyanae has invigorating the spleen and benefiting QI, work of dispeling the wind Blood effect, Rhizoma Polygonati Cirrhifolii has strong spleen stomach reinforcing, nourishing lung-YIN effect;Radix Amaranthi Caudati has nourishing and body-strengthening effect, and Alectoria asiatica Du Rietz has benefit Kidney yin and diuretic effect, Fructus Lycii has invigorating the liver and kidney effect, and Chinese liquor has promoting blood circulation, row medicine gesture effect.In material combination, cattle Milk slurry root share with Rhizoma Polygonati Cirrhifolii, Radix Amaranthi Caudati, Alectoria asiatica Du Rietz, Fructus Lycii, to strengthen the five internal organs vigour and orthofunction ability, Chinese liquor and Many raw materials coordinate, and can improve promoting flow of QI and blood level, can play efficacy enhanced by wine again, wine helps the effect of the efficacy of a drug.Above-mentioned raw material of Chinese medicine Through nature and flavor through belonging to dialectical compatibility, complement each other using, evade restriction or checking relation in five elements, thus effectively given play to tracking the five internal organs and circulation of qi promoting work Effect of blood, to reach to cure the sclerodermatous purpose of system type.
The present invention has a characteristic that novel formula, with low cost, curative effect is preferable.
Using method:
1, this medicine is Orally-administered decoction medicine.
2, consumption: every day potion.Every dose of priority is decocted twice, is decocted by head, two decocts twice after the medicine juice decocted merges, at twice Take.
3, medicine time: the upper and lower noon is each once.Within two hours, take medicine after the meal.
4, medicine temperature control: decoction being taken warmly.
Points for attention:
During treatment, diet air cooling, greasy or irritant food.
Detailed description of the invention:
Embodiment 1: a kind of treat the sclerodermatous decoction medicine of system type material combination be: Radix Fici beecheyanae 40 grams, tiger Each 13 grams of Rhizoma Zingiberis Recens, Radix Amaranthi Caudati, each 8 grams of Alectoria asiatica Du Rietz, Fructus Lycii, 60 ° of Chinese liquor 15 milliliters.The preparation method of this medicine is: first by upper State four taste choppings before raw material of Chinese medicine, put in decocting container together with Fructus Lycii, add water to exceed powder 4-5cm and be advisable, then add Heat decocts stopping in 20 minutes, remove slag and take medicine of a warm nature juice, finally pours Chinese liquor and stirs evenly.
Embodiment 2: a kind of treat the sclerodermatous decoction medicine of system type material combination be: Radix Fici beecheyanae 50 grams, tiger Each 15 grams of Rhizoma Zingiberis Recens, Radix Amaranthi Caudati, each 10 grams of Alectoria asiatica Du Rietz, Fructus Lycii, 60 ° of Chinese liquor 20 milliliters.The preparation method of this medicine is: first by upper State four taste choppings before raw material of Chinese medicine, put in decocting container together with Fructus Lycii, add water to exceed powder 4-5cm and be advisable, then add Heat decocts stopping in 20 minutes, remove slag and take medicine of a warm nature juice, finally pours Chinese liquor and stirs evenly.
Clinical therapeutic efficacy:
Experimentation: 2010 to 2014 years, uses this technical scheme to treat system type Patients with scleroderma totally 12 example, wherein Male 11 example, women 1 example.Minimum 26 years old of patient age, maximum 66 years old, wherein 30-50 year patient 8 example, account for 66%.Sick time The shortest person about 10 days, elder reach about half a year, and wherein 9 example sick times are between 20-45 days.Control by technique scheme Treat, within 15 days, be a course for the treatment of, treat and i.e. stop two courses for the treatment of.
Diagnostic criteria: one treats the sclerodermatous decoction medicine of system type, the disease controlled, and its symptom is defined as: originally Acra feels cold, pale or livid purple and have substantive edema, skin is the hardest soon, it is impossible to pinched, and there is waxy gloss on surface, and with Pigmentation, and then atrophoderma is thinning, subcutaneous tissue and muscle become hardening, are close to skeleton, form hardwood tabular etc..
Curative effect judging standard: whether Outcome measure Main Basis disappears in this disease symptoms, is specifically divided into following three grades: fully recover from an illness More, after patient on medication, all symptoms of disease are wholly absent;After improvement patient on medication, the big portion of all symptoms of disease Divide and disappear or substantially alleviate;After refractory patient's drug administration, all symptoms of disease have no to disappear.
Therapeutic outcome: treat system type Patients with scleroderma 12 example, 10 days recovery from illness 1 examples of medication with decoction medicine of the present invention, use Medicine is fully recovered 2 examples for 11-15 days, and medication is fully recovered 4 examples for 16-30 days, and medication takes a turn for the better after two courses for the treatment of 5 examples.In one course for the treatment of, cure rate is 25%, in two courses for the treatment of, cure rate is 58%, and effective percentage is 100%.The wherein sick time 9 example patients between 20-45 days, 6 examples recovery from illness after two courses for the treatment of of medication, cure rate accounts for 67%;The sick time 2 example patients more than 45 days, after two courses for the treatment of of medication 1 example recovery from illness, cure rate accounts for 50%.Wherein 30-50 year between 8 example patients, 6 examples recoveries from illness after two courses for the treatment of of medication, cure rate accounts for 75%;The age 3 example patients more than 50 years old, 1 example recovery from illness after two courses for the treatment of of medication, cure rate accounts for 33%.Thus analyze, this Bright medicine patient outcomes shorter to the course of disease longer patient of the course of disease to be significantly better than, patient outcomes lighter to the age wants remote It is much better than older patient.

Claims (1)

1. the treatment sclerodermatous decoction medicine of system type, it is characterised in that this medicine is made up of following raw material medicaments: cattle Milk slurry root 40-50 gram, each 13-15 gram of Rhizoma Polygonati Cirrhifolii, Radix Amaranthi Caudati, each 8-10 gram of Alectoria asiatica Du Rietz, Fructus Lycii, 60 ° of Chinese liquor 15-20 millis Rising, the preparation method of this medicine is, first by four taste chopping before above-mentioned raw material of Chinese medicine, puts in decocting container together with Fructus Lycii, adds Water paramount go out powder 4-5cm be advisable, then heating decoct stopping in 20 minutes, remove slag and take medicine of a warm nature juice, finally pour Chinese liquor and stir evenly i.e. Become.
CN201610820016.6A 2016-08-27 2016-08-27 Decoction pharmaceutical for treating systematic scleroderma Pending CN106309915A (en)

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CN201610820016.6A CN106309915A (en) 2016-08-27 2016-08-27 Decoction pharmaceutical for treating systematic scleroderma

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113214931A (en) * 2021-06-17 2021-08-06 禄炳云 Maotai-flavor liquor containing wild cymbidium grains and brewing method of Maotai-flavor liquor

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113214931A (en) * 2021-06-17 2021-08-06 禄炳云 Maotai-flavor liquor containing wild cymbidium grains and brewing method of Maotai-flavor liquor
CN113214931B (en) * 2021-06-17 2023-10-20 禄炳云 Amaranthus caudatus grain Maotai-flavor white spirit and brewing method thereof

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Application publication date: 20170111