CN106309412A - Compound ethanol disinfectant - Google Patents
Compound ethanol disinfectant Download PDFInfo
- Publication number
- CN106309412A CN106309412A CN201610887467.1A CN201610887467A CN106309412A CN 106309412 A CN106309412 A CN 106309412A CN 201610887467 A CN201610887467 A CN 201610887467A CN 106309412 A CN106309412 A CN 106309412A
- Authority
- CN
- China
- Prior art keywords
- ethanol
- chlorhexidine acetate
- compound recipe
- disinfectant
- disinfection liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Abstract
The invention relates to a compound ethanol disinfectant which is prepared by adding deionized water into ethanol and chlorhexidine acetate used as main effective components. The two components have identical and complementary actions in the aspect of disinfection. The compound ethanol disinfectant has reasonable matching of related components, and is free of toxic or harmful components to the human body; and the manufacturing technique is simple and feasible. The solution produced according to the formula has stable performance, can quickly kill Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa and other natural bacteria on the skin surface. The toxicity test indicates that the compound ethanol disinfectant has no toxic actions on the human body, does not have irritation or anaphylactic reaction to the skin, is an ideal safe reliable skin disinfectant, and has strong killing effects on Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and other natural bacteria on the skin surface.
Description
Technical field
The present invention relates to a kind of disinfectant solution, be specifically related to compound recipe ethanol disinfection liquid, belong to medical field.
Background technology
Ethanol is modal, is also the most universal, disinfectant solution the most familiar to people.Ethanol acts on bacterial cell first
Playing dehydration, ethanol molecule enters into the peptide chain of protein molecule and alleviates, and makes protein generation degeneration precipitate.Ethanol has very
Strong osmosis, is easier to penetrate in bacterial body so that bacterial cell destroys and dissolves.Ethanol is generally by bacterial enzyme system
System, particularly dehydrogenase and oxidase etc., hinder homergy and suppress the growth and breeding of antibacterial.Ethanol is to bacterial reproduction
Body, fungus and virus have good killing action, show according to the study: ethanol can kill rapidly bacterial propagule, but gram
Positive bacteria is higher compared with negative bacterium to ethanol drag.60% 75% ethanol are to micrococcus scarlatinae, gonococcus, Bacillus typhi one-level
Bacillus pyocyaneus then can kill in 1 minute, and effect 5min can kill the bacterial propagule including mycobacteria.Ethanol belongs to
In moderate disinfectant, its bactericidal action is very fast, and Disinfection Effect is reliable.Little, nontoxic to human body skin zest, lossless to article
Evil, is used for the sterilization of skin, mucosa.Under normal circumstances, folk prescription ethanol content is the sterilization effect of solution of 70% 75%
Fruit is the most notable.Present stage, the ethanol used by folk prescription ethanol disinfection liquid is all to extract from excellent plant, but is planted by grain etc.
The ethanol cost that thing is extracted is the highest, in order to reach equal even preferably sterilization, bactericidal effect, compound ethanol disappears
The development of venom and exploitation are highly significant.
Summary of the invention
For according to problem above, it is proposed that a kind of compound recipe ethanol disinfection liquid.
The technical scheme that the present invention takes is: this formula calculates with preparation 1000kg compound recipe ethanol disinfection liquid: ethanol
530kg, chlorhexidine acetate 1.0kg, deionized water 469kg, compound recipe ethanol disinfection liquid 1000kg, ethanol (application layer) content >=
95%, chlorhexidine acetate content >=97.5%；Technological process illustrates: 1, weighing content is 95% medical ethanol 530kg, 2, weigh
Content is 99.0% chlorhexidine acetate 1.0kg, 3, weigh deionized water 469kg, 4, three mix and be sufficiently stirred for 20 minutes, make
Abundant dissolving, 5, impurities in filtration treatment ethanol, filter once with pp fibre core, then with microporous membrane separating and filtering one
Secondary, and stand, 6, solution to filtering and standing carry out assay, if meet company standard, 7, be washed with deionized water clean
Vial carries out fill, 8, enter bottle after, sealing, post label, 9, put in storage with dedicated paper case packing.
The present invention is colourless transparent liquid, bitter in the mouth, has the abnormal smells from the patient of ethanol, soluble in water, inventive formulation component:
| Material name | Specification | Throwing amount |
| Ethanol stock solution (content >=95%) | Medical grade | 530 |
| Chlorhexidine acetate (content >=97.5%) | Pharmaceutical grade | 1.0 |
| Deionized water | 469 |
The present invention, its water solublity and ethanol dissolubility at very low concentrations, to Gram-positive and negative bacteria brood body
Have stronger killing action, fungus, tubercule bacillus and spore had inhibitory action, have when for skin degerming quick-acting instead
Should, and there is cumulated activity, use and resident flora once can be made to reduce 97.5%, reuse resident flora and may decrease to
99%, chlorhexidine acetate is difficult to absorption of human body, and people is administered orally 2g chlorhexidine acetate every day, continuous one week, without toxic reaction, low
Poison, safe and reliable, the mechanism of chlorhexidine acetate bactericidal action is to be adsorbed in bacterial cell surface, destroys cell membrane and causes endochylema group
Part infiltration, the activity of suppression dehydrogenase.
Bactericidal effect of the present invention, this disinfectant solution stock solution sterilization logarithm value >=4.00 to Candida albicans effect 1min, should
Disinfectant solution stock solution sterilization logarithm value >=5.00 to pseudomonas aeruginosa effect 1min, this disinfectant solution stock solution disinfective action
2min, averagely kills logarithm value >=1.00 to skin table natural bacteria, sterilizes qualified.
Beneficial effect acquired by the present invention:
Owing to present invention employs technique scheme, have employed ethanol, chlorhexidine acetate are that principle active component adds
Deionized water configuration forms.Two kinds of compositions have identical and complementary effect to sterilization.The collocation of its relevant content composition is reasonable, no
Containing to human body poisonous and harmful element, processing technology is simple, feasible.The solution property produced by formula is stable, can quickly kill gold
The skin surface natural bacterias such as Staphylococcus aureus, Candida albicans, pseudomonas aeruginosa, toxicity test shows that compound recipe ethanol disappears
Venom is to the effect of human non-toxic's property, to no skin irritation, without anaphylaxis, is a kind of ideal, safety, reliably
Disinfectant liquid for skin, has stronger to skin surface natural bacterias such as staphylococcus aureus, pseudomonas aeruginosa, Candida albicans
Killing action.
The ultimate principle of the present invention and principal character and advantages of the present invention have more than been shown and described.The technology of the industry
Personnel, it should be appreciated that the present invention is not restricted to the described embodiments, simply illustrating this described in above-described embodiment and description
The principle of invention, without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, and these become
Change and improvement both falls within scope of the claimed invention.Claimed scope by appending claims and
Equivalent defines.
Accompanying drawing explanation
Fig. 1 is the flowage structure figure of the present invention.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, the illustrative examples invented at this and explanation
It is used for explaining the present invention, but not as a limitation of the invention.
The technical scheme that the present invention takes is: this formula calculates with preparation 1000kg compound recipe ethanol disinfection liquid: ethanol
530kg, chlorhexidine acetate 1.0kg, deionized water 469kg, compound recipe ethanol disinfection liquid 1000kg, ethanol (application layer) content >=
95%, chlorhexidine acetate content >=97.5%；Technological process illustrates: 1, weighing content is 95% medical ethanol 530kg, 2, weigh
Content is 99.0% chlorhexidine acetate 1.0kg, 3, weigh deionized water 469kg, 4, three mix and be sufficiently stirred for 20 minutes, make
Abundant dissolving, 5, impurities in filtration treatment ethanol, filter once with pp fibre core, then with microporous membrane separating and filtering one
Secondary, and stand, 6, solution to filtering and standing carry out assay, if meet company standard, 7, be washed with deionized water clean
Vial carries out fill, 8, enter bottle after, sealing, post label, 9, put in storage with dedicated paper case packing.
The present invention is colourless transparent liquid, bitter in the mouth, has the abnormal smells from the patient of ethanol, soluble in water, inventive formulation component:
| Material name | Specification | Throwing amount |
| Ethanol stock solution (content >=95%) | Medical grade | 530 |
| Chlorhexidine acetate (content >=97.5%) | Pharmaceutical grade | 1.0 |
| Deionized water | 469 |
The present invention, its water solublity and ethanol dissolubility at very low concentrations, to Gram-positive and negative bacteria brood body
Have stronger killing action, fungus, tubercule bacillus and spore had inhibitory action, have when for skin degerming quick-acting instead
Should, and there is cumulated activity, use and resident flora once can be made to reduce 97.5%, reuse resident flora and may decrease to
99%, chlorhexidine acetate is difficult to absorption of human body, and people is administered orally 2g chlorhexidine acetate every day, continuous one week, without toxic reaction, low
Poison, safe and reliable, the mechanism of chlorhexidine acetate bactericidal action is to be adsorbed in bacterial cell surface, destroys cell membrane and causes endochylema group
Part infiltration, the activity of suppression dehydrogenase；Bactericidal effect of the present invention, this disinfectant solution stock solution sterilization to Candida albicans effect 1min
Logarithm value >=4.00, this disinfectant solution stock solution sterilization logarithm value >=5.00 to pseudomonas aeruginosa effect 1min, this disinfectant solution
Stock solution disinfective action 2min, averagely kills logarithm value >=1.00 to skin table natural bacteria, sterilizes qualified.
Beneficial effect acquired by the present invention: owing to present invention employs technique scheme, have employed ethanol, acetic acid
Hibitane be principle active component add deionized water configuration form.Two kinds of compositions have identical and complementary effect to sterilization.Its
Rationally, without to human body poisonous and harmful element, processing technology is simple, feasible in relevant content composition collocation.By formula produce molten
Liquid stable performance, can quickly kill the skin surfaces such as staphylococcus aureus, Candida albicans, pseudomonas aeruginosa natural
Bacterium, toxicity test shows that compound recipe ethanol disinfection liquid, to the effect of human non-toxic's property, to no skin irritation, without anaphylaxis, is one
Plant ideal, safety, reliable disinfectant liquid for skin, to staphylococcus aureus, pseudomonas aeruginosa, Candida albicans
The skin surface natural bacterias such as bacterium have stronger killing action.
Claims (4)
1. compound recipe ethanol disinfection liquid, is characterized in that: this formula calculates with preparation 1000kg compound recipe ethanol disinfection liquid: ethanol 530kg,
Chlorhexidine acetate 1.0kg, deionized water 469kg, compound recipe ethanol disinfection liquid 1000kg, ethanol (application layer) content >=95%, vinegar
Acid chlorhexidine >=97.5%；Technological process illustrates: 1, weighing content is 95% medical ethanol 530kg, 2, weigh content and be
99.0% chlorhexidine acetate 1.0kg, 3, weigh deionized water 469kg, 4, three mix and be sufficiently stirred for 20 minutes, be allowed to abundant
Dissolve, 5, impurities in filtration treatment ethanol, filter once with pp fibre core, then with microporous membrane separating and filtering once, and quiet
Put, 6, solution to filtering and standing carry out assay, if meet company standard, 7, be washed with deionized water clean vial and enter
Row fill, 8, enter bottle after, sealing, post label, 9, with dedicated paper case packing put in storage.
2. compound recipe ethanol disinfection liquid as claimed in claim 1, it is characterised in that: the present invention is colourless transparent liquid, and bitter in the mouth has
The abnormal smells from the patient of ethanol, soluble in water, inventive formulation component:
3. compound recipe ethanol disinfection liquid as claimed in claim 1, it is characterised in that: the present invention, its water solublity and ethanol dissolubility exist
Under the lowest concentration, Gram-positive and negative bacteria brood body there is stronger killing action, to fungus, tubercule bacillus and bud
Spore has inhibitory action, has quick-acting reaction, and have cumulated activity when for skin degerming, uses and once can make resident flora
Reducing 97.5%, reuse resident flora and may decrease to 99%, chlorhexidine acetate is difficult to absorption of human body, and people is administered orally 2g every day
Chlorhexidine acetate, continuous one week, without toxic reaction, low toxicity, safe and reliable, the mechanism of chlorhexidine acetate bactericidal action was to be adsorbed in
Bacterial cell surface, destroys cell membrane and causes endochylema component to permeate, the activity of suppression dehydrogenase.
4. compound recipe ethanol disinfection liquid as claimed in claim 1, it is characterised in that: bactericidal effect of the present invention, this disinfectant solution stock solution
Sterilization logarithm value >=4.00 to Candida albicans effect 1min, this disinfectant solution stock solution is to pseudomonas aeruginosa effect 1min's
Sterilization logarithm value >=5.00, this disinfectant solution stock solution disinfective action 2min, to skin table natural bacteria averagely kill logarithm value >=
1.00, sterilize qualified.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610887467.1A CN106309412A (en) | 2016-10-11 | 2016-10-11 | Compound ethanol disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610887467.1A CN106309412A (en) | 2016-10-11 | 2016-10-11 | Compound ethanol disinfectant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106309412A true CN106309412A (en) | 2017-01-11 |
Family
ID=57821407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610887467.1A Pending CN106309412A (en) | 2016-10-11 | 2016-10-11 | Compound ethanol disinfectant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106309412A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110496217A (en) * | 2018-05-18 | 2019-11-26 | 马德强 | It is a kind of to take into account desensitization, antipruritic and skin lesion reparation germicide for skin |
| CN110496190A (en) * | 2018-05-18 | 2019-11-26 | 马德强 | It is a kind of with desensitization, antipruritic and skin lesion repair function disinfectant liquid for skin |
| CN110496191A (en) * | 2018-05-18 | 2019-11-26 | 马德强 | It is a kind of to take into account desensitization, the net germicide for skin of antipruritic and skin lesion reparation wet poison |
| CN111264567A (en) * | 2020-03-02 | 2020-06-12 | 达威控股有限公司 | Sterilization disinfectant, preparation method and application thereof |
| CN111345314A (en) * | 2020-03-02 | 2020-06-30 | 上海星耀医学科技发展有限公司 | Disinfectant, disinfectant wet tissue and disinfection method for novel coronavirus |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565180A (en) * | 2003-06-16 | 2005-01-19 | 史英 | Antiseptic solution |
| CN105816339A (en) * | 2016-04-21 | 2016-08-03 | 江苏鱼跃信息系统有限公司 | Hand-washing-free disinfection solution and preparation method thereof |
-
2016
- 2016-10-11 CN CN201610887467.1A patent/CN106309412A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565180A (en) * | 2003-06-16 | 2005-01-19 | 史英 | Antiseptic solution |
| CN105816339A (en) * | 2016-04-21 | 2016-08-03 | 江苏鱼跃信息系统有限公司 | Hand-washing-free disinfection solution and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 唐慧等: "醋酸氯己定消毒液的亚急性毒性试验", 《预防医学论坛》 * |
| 李凤等: "葡萄糖酸氯己定醇消毒液对外科手消毒效果观察", 《中国消毒学杂志》 * |
| 苏裕心等: "一种速干性消毒液消毒相关性能实验研究", 《中国消毒学杂志》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110496217A (en) * | 2018-05-18 | 2019-11-26 | 马德强 | It is a kind of to take into account desensitization, antipruritic and skin lesion reparation germicide for skin |
| CN110496190A (en) * | 2018-05-18 | 2019-11-26 | 马德强 | It is a kind of with desensitization, antipruritic and skin lesion repair function disinfectant liquid for skin |
| CN110496191A (en) * | 2018-05-18 | 2019-11-26 | 马德强 | It is a kind of to take into account desensitization, the net germicide for skin of antipruritic and skin lesion reparation wet poison |
| CN111264567A (en) * | 2020-03-02 | 2020-06-12 | 达威控股有限公司 | Sterilization disinfectant, preparation method and application thereof |
| CN111345314A (en) * | 2020-03-02 | 2020-06-30 | 上海星耀医学科技发展有限公司 | Disinfectant, disinfectant wet tissue and disinfection method for novel coronavirus |
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Legal Events
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| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170111 |
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| RJ01 | Rejection of invention patent application after publication |