CN1063049C - Full silkworm powder, its prepn. and use - Google Patents
Full silkworm powder, its prepn. and use Download PDFInfo
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- CN1063049C CN1063049C CN96116507A CN96116507A CN1063049C CN 1063049 C CN1063049 C CN 1063049C CN 96116507 A CN96116507 A CN 96116507A CN 96116507 A CN96116507 A CN 96116507A CN 1063049 C CN1063049 C CN 1063049C
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Abstract
The present invention relates to full silkworm powder which can be used as a medicine or nutritive health-care product, a preparation method thereof and an application thereof. The full silkworm powder is prepared from silkworm just before spinning out silk, and thus, the activity of all the effective components in the silkworm body is kept. The full silkworm powder takes a good treatment or health care function of a regulating agent on metabolic balance of human bodies.
Description
The present invention relates to a kind of full silkworm powder that can be used as medicine or nutrient and healthcare products, the preparation method of this full silkworm powder, and the purposes of described full silkworm powder.
Aspect traditional Chinese medicines, " Compendium of Materia Medica " had the record of be used as medicine (Chinese crude drugs) such as Pupa bombycis, Bombycis mori, Bombyx Batryticatus, silkworm silk, Bombyx bombycis, Bombyx mori L., Periostachum bombycis for a long time, but there is no big progress so far, face the healthy full silkworm that is placed on small straw bundles to spin cocoons and in all age never did the trial and the research of being used as medicine.
Aspect Western medicine, existing is that the research work of raw material effective component extracting obtains domestic and international patent with Pupa bombycis, Bombycis mori, Bombyx mori L..Domestic, be widely used from of the auxiliary Supporting Therapy agent of Pupa bombycis extraction aminoacids complex as radiation and chemotherapy.Bombyx mori L. extract for treating hepatitis anemia and leukopenia are also succeeded.Obtained having of patent abroad: Gram-positive and negative bacterium are all had the pentapeptide (from the silkworm body) of antibacterial activity and separating of glycopeptide (from silkworm body fluid), (referring to the Japan Patent JP6316596s, JP95100716 and J57188525) such as separation of agglutinin from Bombyx mori L. with antiviral activity.Researcher is all utilizing silkworm larva and pupa can produce multiple antibiotic substance after inducing both at home and abroad, thereby attempts to develop the new biological antibiotic agent of a class.In addition, utilize technique for gene engineering, studying both at home and abroad with reorganization silkworm nuclear polyhedrosis virus is that carrier makes production alpha-interferon, hepatitis B vaccine and BMP etc. reach the suitability for industrialized production level.
Aspect nutritional health food, domestic existing in recent years people produces pupa albumen from Pupa bombycis, makes pupa extract of protein goods, reaches the food additive level.Also useful alcohol leaching method leaches biological active substances from male Bombycis mori, is used to do the health product that are suitable for person in middle and old age of building body, kidney invigorating and YANG supporting, as " prolong to give birth to protect and protect liquid " in Shenyang, and " Long Yanchun " in Dalian and " " the public tonic wine of moth " in Shaanxi.
Both at home and abroad in recent years to facing (comprising blood, Digestive system, body fluid) contained trophism and the existing comparatively extensive and deep research of medicative composition in the healthy silkworm body of being placed on small straw bundles to spin cocoons.And determined that the composition with certain drug effect has: from silkworm larva and silkworm body fluid, separate obtain Gram-positive and negative bacterium are all had the pentapeptide and the glycopeptide of antibacterial action, separate the vitamin V that is rich in that obtains the silkworm larva from 4 ages and 5 ages
B5And V
PPBioactive substance A, the antiviral agglutinin that exists in Cu/ZnSOD that the antiinflammatory resistant effect is arranged that exists in the hemolymph and the digestive tract etc.
Face in the silkworm body of being placed on small straw bundles to spin cocoons and still contain nutritious material, as a large amount of (per 100 milliliters contain 1.2 grams) human body growth promoter, metabolism and necessary 18 seed amino acids that earn a bare living that exist in the blood, (containing 0.4 gram in per 100 milliliters) the endogenous energy substance trehalose that exists in the silkworm blood, the V that is rich in high nutritive value
B5And V
PPBioactive substance A and have resisting fatigue and the SOD of activity of fighting against senium etc.
Even so, not seeing so far both at home and abroad has and will face the report that the healthy full silkworm that is placed on small straw bundles to spin cocoons is applied as medicine and health product, and all also has following problems in the relevant prior art:
(1) the prior art polyphyly is handled natural material with chemistry or Enzymology method, just all can introduce chemistry (acid, alkali, organic solvent) and other impurity (with the irrelevant material of effective ingredient, comprising enzyme, other catabolites) inevitably and pollute in product.
(2) owing to the relation of process conditions, products obtained therefrom only contains a certain or limited several effective ingredient in the natural material, or even the composition that comes to harm, so that effective ingredient is not comprehensive in the product.
The present invention system follows " integral body " and " dialectical " thinking of the traditional Chinese medical science, be different from the west researcher and bias toward of the isolation effect of each composition of consideration human body, therefore the present invention is not that employing chemistry or extracting method separate a certain or certain several effective ingredient in the silkworm body isolatedly, but pay attention to research the activity of facing all effective ingredient in the healthy full silkworm body of being placed on small straw bundles to spin cocoons is all kept, and utilize their mutual complementary comprehensive effects, the body metabolism balance is played the good treatment or the health-care effect of regulator, and can not avoid in the prior art products that the front mentioned ubiquitous effective ingredient comprehensive and be subject to chemistry and other irrelevant material pollution problems.
Secondly, in Chinese medicine processing processing and health food production technology, introduce the advanced processing technique of lyophilisation, to reach the bioactive purpose of the composition of remaining valid, this is not adopted exhaustedly in the prior art, and lyophilisation equipment makes design of the present invention become the product with industrial applicibility.This product is taken 0.1 gram for each person every day through Preliminary Clinical Observation, adheres to taking about 20 days, just has obvious treatment and health-care effect.This explanation the present invention can produce, and is easy to use, and can produce positive medical treatment, health-care effect.Practice has proved that the present invention has practicality widely.
An object of the present invention is to provide and to keep facing the health active healthy silkworm powder of being placed on small straw bundles to spin cocoons that faces of interior all effective ingredient of silkworm body entirely of being placed on small straw bundles to spin cocoons, utilize complementary comprehensive effect between the described various effective ingredient that face the healthy silkworm powder of being placed on small straw bundles to spin cocoons, the body metabolism balance is played the good treatment or the health-care effect of regulator, and can avoid in the prior art products ubiquitous effective ingredient not comprehensive, and be subject to chemistry and other irrelevant material pollution problems.
Another object of the present invention provides the preparation method of described full silkworm powder.
A further object of the invention is as medicine and nutrient and healthcare products with described full silkworm powder.
Term used herein " faces the full silkworm that is placed on small straw bundles to spin cocoons " and is meant and faces the silkworm that weaves silk, because of the kind difference of silkworm, can be 3 ages, 4 ages or 5 age silkworm.
The objective of the invention is to realize by following technical scheme.
A kind of full silkworm powder comprises the whole compositions that face the full silkworm that is placed on small straw bundles to spin cocoons after the pulverizing.
A kind of preparation method of full silkworm powder comprises:
1) choose fresh and alive health and face the full silkworm that is placed on small straw bundles to spin cocoons, quick-freezing is preserved as raw material behind sterilization, also can directly face the full silkworm that is placed on small straw bundles to spin cocoons as raw material with above-mentioned health behind sterilization;
2) the raw material speed that quick-freezing is preserved is melted, and obtains a kind of full silkworm slurry after rubbing and the homogenate;
3) with above-mentioned full silkworm slurry after filtration, lyophilisation, pulverize the back a kind of freeze dried silkworm powder.
A kind of purposes of full silkworm powder is with above-mentioned steps 3) in silkworm powder be packed as single preparations of ephedrine, or with no incompatibility and have other Chinese medical concrete (as the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis etc.) of the curative effect of complementing each other to make compound preparation to use, wherein the ratio of silkworm powder and other Chinese medical concrete is 1 part of (weight) silkworm powder and 5 to 10 parts of (weight) Chinese medical concretes.
The another kind of purposes of full silkworm powder is with above-mentioned steps 3) in silkworm powder be distributed into health functional food, perhaps mix with other health food (as calcium powder, milk powder and glucose etc.), make the compound health-care functional food and use, wherein the ratio of silkworm powder and other health food is 1: 1 to 1: 10.This product also can be used as food additive and uses.
The present invention is described in further detail below in conjunction with specific embodiment.Preparation example 1
The full silkworm speed of being placed on small straw bundles to spin cocoons of facing of 2 kilograms of fresh and alive health that quick-freezing is preserved through soak 5-10 minute in ClO 2 solution (0.2-1.0%) after is melted, add 1 kilogram of normal saline, rub back homogenate, the full silkworm slurry that obtains places the lyophilisation dish with filtrate after filtering, in-48 ℃ of freezing insulations after 3 hours, open vacuum pump 1 hour, and progressively heated up again, per hour heat up 2-5 ℃, after+37 ℃, stop to heat up, be incubated 2-3 hour, front and back need 32-48 hour, then with the lyophilisation product by taking out in the case, pulverize, porphyrize gets about 192 grams of product, be distributed into 0.1 gram/bag, the sealing bag mouth promptly.Preparation example 2
The healthy full silkworm of immersion after 5-10 minute is as raw material (preserving without quick-freezing) in ClO 2 solution (0.2-1.0%) except using, and other operation is identical with preparation example 1.Preparation example 3
According to preparation example 1 described method, the resulting full silkworm lyophilized powder of 0.1 gram and 0.5 to 1.0 restrained be selected from the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Et Caulis Acanthopanacis Senticosi and the Fructus Schisandrae Chinensis extractum one or more and mix, make compound preparation.Preparation example 4
According to preparation example 1 described method, in resulting full silkworm lyophilized powder and calcium powder, instant nonfat milk powder and the glucose one or more with 1: 1 to 1: 10 mixed, are obtained a kind of health functional food.The test example
Experiment material: full silkworm powder of the present invention is a kind of light green-gray in color powder, and no special odor is water-soluble.Laboratory animal is selected Kunming kind healthy mice for use, body weight 18-20 gram, and male and female half and half are provided by laboratory animal portion of Shanghai Medical Univ, the real moving regular grade 02-22-1 of Shanghai doctor.Experimental technique
Animal by sex sub-cage rearing 3 days, to conform, is distinguished the component group by body weight at random,, establish 6 dosage groups and 1 matched group altogether, each 10 of every group of experiment mice male and female with probit method design dosage.Tried the thing dissolved in distilled water, but high dose group is difficult for all dissolvings, so make suspension, with the high dose group is mother solution, be mixed with the solution of variable concentrations through dilution, the maximum volume that is tried the thing administration is that per 10 gram body weight are irritated 0.25 milliliter in stomaches, irritates before the stomach one night of animal fasting.The maximum dose level group is irritated stomach in one day at twice, and all the other each group is all once irritated stomach, treats that all dosage pours into to give feedstuff in back two hours again.Irritate general situation, poisoning symptom and the death condition of observing mice behind the stomach, the observation period is 10 days.Experimental result
After above-mentioned aqueous solution or aqueous suspensions per os gave experiment mice, each dosage group there is no any untoward reaction in 10 day observation period, and hair color is normal, and appetite is good, and activity freely an example death does not take place.The results are shown in Table 1.
Table 1 its mouse oral acute toxicity (LD50) and maximum tolerated dose
The acute toxicity of institute's test agent, its mouse oral LD50 value＞11 gram/kilograms belongs to nontoxic level.Maximum tolerated dose＞11 gram/kilograms to its mouse oral.
Embodiment
The taking dose of full silkworm powder of the present invention is 0.1 gram for each person every day, divides sooner or later twice, licks to maxillary with the tip of the tongue immediately after pouring described silkworm powder into oral cavity when taking, and mucosa absorption needn't be used mixing in water for oral taking.
Example 1 women, 60 years old, the breast carcinoma medical history is arranged, once caused bradycardia all the year round because of operation and chemotherapy, take this product before, heart beating only 40-45 time/minute can not too much be walked, and climbs the building, otherwise sensation of oppression over the chest with shortness of breath, has insupportable fatigue to feel.After taking 21 days, heart beating progressively improves, and has now brought up to 56-60 time/minute, climbs no longer sensation of oppression over the chest with shortness of breath of building on foot, and appetite is very good, and appearance, spirit all have the rejuvenation sensation.
Example 2 women 21 years old, have the viral myocarditis medical history.After school participated in 800 meters long-distance runnings, always tired breathe heavily squatted down on the ground and is reluctant to speak with the classmate before taking.Take this product only after 7 days, participate in long-distance running again, no longer asthma feels very light unexpectedly.
Example 3 middle aged woman workers, the sense uncomfortable in chest of breathing hard before taking is obvious, takes this product after 20 days, and the sense uncomfortable in chest of breathing hard disappears.In addition two take the same long-time back of this product and take before compare, conscious stride is obviously light, the whole body is comfortable, these situations illustrate that all this product can improve myocardial function and blood circulation.
Below two these products of example explanation have antiinflammatory disease-resistant, improve the effect of autoimmune ability:
Example 4 men 59 years old have multiple chronic disease (alcoholic liver, cholecystitis, nephritis) before taking, body constitution is poor, myasthenia of limbs, the puffiness of the eyes, often flu.Take this product after 20 days, receive except that stomach and strengthen ordinary circumstances such as complexion improves improve, special obvious variation is that edema disappears, and has no longer caught a cold.
Example 5 woman, 45 years old, take preceding myasthenia of limbs, suffer from chronic because of inflammation for many years, multi-treatment is invalid, often flu.Take this product after 20 days, extremity are strong, and pharyngitis has been cured, and has had no interest.
In sum, this product is expected to become cardiac nutrition, to the auxiliary therapeutic agent of viral myocarditis, bradycardia and upper respiratory tract infection.
6 30 users of example took this product after 20 days, and 80% left and right sides appetite strengthens, and stomach is received increases, and promote the production of body fluid in the oral cavity, obvious resisting fatigue sense is arranged, and conscious health is light, and easy catching a cold is not radiant, and facial fine wrinkle reduces, the white hair minimizing, and dark hair increases gradually.The general effect of taking illustrates that this product can be used as the health functional food of resisting fatigue, defying age, raising body autoimmunity.
Claims (5)
1. full silkworm powder, it is made by following steps:
1) choose fresh and alive health and face the full silkworm that is placed on small straw bundles to spin cocoons, quick-freezing is preserved as raw material after sterilizing, and also can directly face the full silkworm that is placed on small straw bundles to spin cocoons as raw material with above-mentioned health after sterilization;
2) the raw material speed that quick-freezing is preserved is melted, and obtains a kind of full silkworm slurry after rubbing and the homogenate;
3) with above-mentioned full silkworm slurry after filtration, lyophilisation, pulverize the back a kind of freeze dried silkworm powder.
2. the preparation method of a full silkworm powder comprises:
1) choose fresh and alive health and face the full silkworm that is placed on small straw bundles to spin cocoons, quick-freezing is preserved as raw material after sterilizing, and also can directly face the full silkworm that is placed on small straw bundles to spin cocoons as raw material with above-mentioned health after sterilization;
2) the raw material speed that quick-freezing is preserved is melted, and obtains a kind of full silkworm slurry after rubbing and the homogenate;
3) with above-mentioned full silkworm slurry after filtration, lyophilisation, pulverize the back a kind of freeze dried silkworm powder.
3. silkworm powder as claimed in claim 1 is distributed into single preparations of ephedrine or makes compound preparation with one or more Chinese medicine ingredients that are selected from the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Et Caulis Acanthopanacis Senticosi and the Fructus Schisandrae Chinensis, as being used for cardiac nutrition, and to the application of the auxiliary treatment medicine of viral myocarditis, bradycardia and upper respiratory tract infection.
4. the purposes that will show 3 described silkworm powders as right, the mixed proportion that it is characterized in that one or more Chinese medicine ingredients in the described silkworm powder and the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Et Caulis Acanthopanacis Senticosi and the Fructus Schisandrae Chinensis is 1: 5 to 1: 10.
5. silkworm powder as claimed in claim 1 is distributed into health functional food, perhaps be selected from calcium powder, milk powder and the glucose one or more with 1: 1 to 1: 10 mixed, the application of making the compound health-care functional food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96116507A CN1063049C (en) | 1996-09-16 | 1996-09-16 | Full silkworm powder, its prepn. and use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96116507A CN1063049C (en) | 1996-09-16 | 1996-09-16 | Full silkworm powder, its prepn. and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1145227A CN1145227A (en) | 1997-03-19 |
| CN1063049C true CN1063049C (en) | 2001-03-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN96116507A Expired - Fee Related CN1063049C (en) | 1996-09-16 | 1996-09-16 | Full silkworm powder, its prepn. and use |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1109551C (en) * | 2000-07-31 | 2003-05-28 | 赵富清 | Anticancer capsule 'Wushensu' and its extracting and preparing process |
| CN100431554C (en) * | 2006-05-30 | 2008-11-12 | 江苏科技大学 | A method for preparing silkworm powder |
| CN101199553B (en) * | 2007-12-11 | 2010-10-06 | 徐先旭 | Preparing method for treating diabetes whole silkworm powder |
| CA2929177C (en) | 2013-11-11 | 2021-12-07 | Aaron T. DOSSEY | Insect products and methods of manufacture and use thereof |
| CN108124964A (en) * | 2017-12-11 | 2018-06-08 | 长春三真实业有限公司 | A kind of establishing-Yang male silk moth milk tablet |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1082408A (en) * | 1993-07-03 | 1994-02-23 | 魏鹏飞 | A kind of male silk moth extracting liquid and method for making thereof |
| CN1099623A (en) * | 1994-11-09 | 1995-03-08 | 魏鹏飞 | Refined male silk moth powder and producing method |
-
1996
- 1996-09-16 CN CN96116507A patent/CN1063049C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1082408A (en) * | 1993-07-03 | 1994-02-23 | 魏鹏飞 | A kind of male silk moth extracting liquid and method for making thereof |
| CN1099623A (en) * | 1994-11-09 | 1995-03-08 | 魏鹏飞 | Refined male silk moth powder and producing method |
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| Publication number | Publication date |
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| CN1145227A (en) | 1997-03-19 |
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