CN106290476A - Keep structure and include keeping the detector of structure - Google Patents
Keep structure and include keeping the detector of structure Download PDFInfo
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- CN106290476A CN106290476A CN201610658321.XA CN201610658321A CN106290476A CN 106290476 A CN106290476 A CN 106290476A CN 201610658321 A CN201610658321 A CN 201610658321A CN 106290476 A CN106290476 A CN 106290476A
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- keeper
- orifice plate
- probe
- holding part
- pressure change
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
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Abstract
A kind of for keeping the holding structure of pattern detection orifice plate, orifice plate is with electrode and accommodates sample, keeps structure to include keeper and pressure change-over panel.Keeper includes keeper main body, has the holding part receiving orifice plate；With at least one probe module, it is arranged at the bottom of holding part.Probe module includes multiple contact probe, and its one end includes that the spring contact being perpendicular to the bottom translation of holding part and the other end are electrically connected to keeper control circuit；At least one switchs probe, and its one end includes that the elastic press section being perpendicular to the bottom translation of holding part and the other end are electrically connected to keeper control circuit；With electrical insulating board, contact probe and switch probe are located on electrical insulating board.When orifice plate is received in holding part, the spring contact of the bottom abutment contact probe of orifice plate and the elastic press section of switch probe, spring contact is electrically connected to the electrode being arranged on the bottom of orifice plate, and orifice plate is between the bottom of pressure change-over panel and described holding part.
Description
Technical field
The present invention relates to a kind of holding structure for keeping pattern detection orifice plate, and relate to one and include described holding
The detector of structure.
Background technology
In pattern detection field, particularly in the detection field of liquid biopsy, generally use the hole with multiple holes
Plate holds biological specimen, and electrically conducting bottom the electrode of orifice plate and hole, thus the low current signal of biological specimen can lead to
Cross the signal detection processing unit that electrode exports outside orifice plate.Additionally, because the concentration of captured target molecules is the lowest, lead
The current signal that enable enough detects is the faintest, usually na or pico-ampere magnitude.And in current existing detection equipment,
Typically can only realize a milliampere magnitude being detected.Keeping structure thus, it is desirable to a kind of, it can repeat place orifice plate and prevent orifice plate
Overturn, the current signal of electrode is exported signal detection processing unit, it is ensured that the loading of the signal of telecommunication and the biography of detection signal
Defeated stability, and reduce the interference of the external electromagnetic current signal to being exported as far as possible, realize the sealing of detection equipment simultaneously,
Prevent external moisture, dust and liquid from penetrating into device interior.
Summary of the invention
The present invention is a kind of for keeping the holding structure of pattern detection orifice plate to realize above-mentioned purpose by proposing, described
Orifice plate is with electrode and accommodates sample.This holding structure includes keeper and pressure change-over panel.Keeper includes: keeper master
Body, has the holding part receiving described orifice plate；With at least one probe module, it is arranged at the bottom of described holding part.
Described probe module includes: multiple contact probes, and one end of described contact probe includes being perpendicular to described holding part
The spring contact of bottom translation and the other end be electrically connected to keeper control circuit；At least one switchs probe, described switch
One end of probe includes that the elastic press section being perpendicular to the bottom translation of described holding part and the other end are electrically connected to keeper control
Circuit processed；With electrical insulating board, described contact probe and described switch probe are located on described electrical insulating board.When described orifice plate quilt
When receiving in described holding part, the spring contact of contact probe described in the bottom abutment of described orifice plate and described switch probe
Elastic press section, described spring contact is electrically connected to the electrode being arranged on the bottom of described orifice plate, and described orifice plate is positioned at institute
State between the bottom of pressure change-over panel and described holding part.
Preferably, described pressure change-over panel is rotatably mounted around the one axis of symmetry.
Preferably, described keeper includes that the keeper rotated relative to described keeper main body around first axle is renovated,
Described pressure change-over panel is arranged on described keeper and renovates, and described pressure change-over panel rotate around the axis of symmetry be parallel to
Described first axle.
Preferably, described keeper is renovated to have and is renovated hollow open, described pressure change-over panel be received in described in renovate
In hollow open.
Preferably, described pressure change-over panel and described keeper are renovated and are provided with the rotation retention device cooperated.
Preferably, described pressure change-over panel has the positioner making described orifice plate position.
Preferably, it is a part for detector, and described pressure change-over panel is arranged on the chassis lid of detector.
Preferably, the chassis lid of detector around the second axis rotation and has receiving portion, described pressure relative to cabinet bulk
Power change-over panel is received in described receiving portion, and described pressure change-over panel rotate around the axis of symmetry be parallel to described the
Two axis.
Preferably, described pressure change-over panel and described chassis lid are provided with the rotation retention device cooperated.
Preferably, described pressure change-over panel is the form of hollow, rectangular framework.
Preferably, described holding part includes fence, described fence from the bottom of described holding part outwardly with around institute
State orifice plate, and described holding part is electric insulation integral with described electrical insulating board.
Preferably, described keeper main body includes closed circular wall, described closed circular wall from described keeper main body to
Highlighting outward, and be positioned at the periphery of described fence, described closed circular wall carries sealing member.
Preferably, described keeper also includes the gripper shoe supporting described keeper main body, and described gripper shoe includes breach,
Described contact probe and described switch probe contactlessly pass described breach with described gripper shoe.
Preferably, described gripper shoe is positioned at below described keeper main body, and has towards described keeper main body
Side and the second side of the most described keeper main body, described gripper shoe is fixed to described keeper main body, carries described guarantor
The panel of holder control circuit is fixed to described gripper shoe spaced apart with described gripper shoe in the second side of described gripper shoe.
Preferably, described gripper shoe is made up of metal material.
Preferably, described holding part includes the box body accommodating described orifice plate, and described electrical insulating board is arranged on described box body
On bottom.
Preferably, described keeper main body is made up of metal material.
Preferably, described holding part also includes that orifice plate is close to space.
Preferably, described probe module includes multiple switch probe.
Preferably, described switch probe is normal open switch.
Preferably, it is provided with the error prevention device for described orifice plate bottom described holding part.
The invention still further relates to a kind of detector, it includes above-mentioned holding structure and cabinet.
Holding structure according to the present invention be able to ensure that orifice plate correctly kept and its bottom electrode can with contact spy
Pin contacts securely, thus avoids open circuit so that circuit can be continuous and stablely for the electrode power supply on orifice plate, and electric current
Signal can transmit without interruption.Detector according to the present invention can effectively shield come from the interior space electromagnetic wave and
The electromagnetic radiation of the device interior electronic device electromagnetic interference to the current signal that electrode exports, prevent simultaneously external moisture,
Dust and liquid penetrate into device interior.
In the case of not conflicting, the feature in the same embodiment of the present invention and different embodiment can be mutually combined.
Accompanying drawing explanation
By figure below, those skilled in the art will present invention may be better understood, and advantages of the present invention
To more clearly be embodied.Accompanying drawing described herein is only for illustrating the purpose of embodiment rather than the most feasible embodiment party
Formula, and be not intended to limit the scope of the invention.
Fig. 1 is the axonometric chart of an embodiment of the holding structure according to present aspect；
Fig. 2 A is the profile along its longitudinal direction of contact probe, and Fig. 2 B is that contact probe is when being arranged in electrical insulating board
Schematic diagram；
Fig. 3 schematically shows schematic diagram when orifice plate 9 is pressed against contact probe and switchs probe；
Fig. 4 schematically shows the operation principle of pressure change-over panel；
Fig. 5 is the top view of the holding structure shown in Fig. 1, and wherein Guan Bi renovated by the keeper of keeper；
Fig. 6 is the top view of the holding structure shown in Fig. 1, and wherein the keeper of keeper is renovated and opened；
Fig. 7 is the axonometric chart observed from below of the holding structure shown in Fig. 1；
Fig. 8 is the axonometric chart of the second embodiment of the holding structure according to the present invention；
Fig. 9 is the top view of the holding structure shown in Fig. 8；
Figure 10 is the axonometric chart of the holding structure shown in Fig. 8, it is shown that the bottom of keeper main body；
Figure 11 is the side view cutaway drawing of the holding structure shown in Fig. 8；
Figure 12 is the axonometric chart of the first embodiment of the detector according to the present invention；
Figure 13 is the axonometric chart of the detector shown in Figure 12, and wherein, the enclosing cover of cabinet is opened and keeps structure to be removed；
Figure 14 is the partially schematic of sealing engagement mode between the cabinet of the detector shown in Figure 12 and keeper main body
Figure；
Figure 15 A is the solid viewed from above of the keeper main body of the 3rd embodiment of the holding structure according to the present invention
Figure；
Figure 15 B is the schematic diagram of the example of fence；
Figure 16 is the axonometric chart observed from below of the keeper main body of the holding structure shown in Figure 15；
Figure 17 A and 17B is the schematic diagram of the example of pressure change-over panel；
Figure 18 is the schematic diagram of the second embodiment of the detector according to the present invention；
Figure 19 is the side view cutaway drawing of the detector shown in Figure 18；
Figure 20 and 21 is the schematic diagram of the detector of the holding structure including different embodiment according to the subject invention respectively.
Detailed description of the invention
Below with reference to accompanying drawing to being described in detail according to a preferred embodiment of the invention.By accompanying drawing and corresponding
Explanatory note, skilled person will further understand that feature and the advantage of the present invention.
Fig. 1 shows the holding structure 1 according to the first embodiment of the present invention, and it is used for keeping pattern detection orifice plate (Fig. 1
Not shown in), described orifice plate is with electrode and accommodates sample.This holding structure 1 can include keeper 10.This keeper 10 can wrap
Including keeper main body 100, it can have the holding part 110 being able to receive that orifice plate.Keeper 10 can also include at least one probe
Module 200, is arranged at the bottom 111 of holding part 110.In this first embodiment, keeper 10 can include two probe modules
200 (Fig. 5).
Probe module 200 can include multiple contact probe 210 and electrical insulating board 230.Refer to Fig. 2 A and 2B, it illustrates
The structure of one contact probe 210.As shown in Figure 2 A, contact probe 210 can include contact probe main body 212, such as, have
Tubular form, this contact probe main body 212 can be arranged on electrical insulating board 230 (Fig. 2 B), such as, be worn by interference fit
If.Contact probe main body 212 can at one end have an opening 214, and limit stroke space 213 in inside, the trip space 213 with
Opening 214 connects.Contact probe main body 212 is obstructed at the other end relative with opening 214, and includes being electrically connected at this end
It is connected to the terminal 215 of keeper circuit.Contact probe 210 can also include spring contact 211, and spring contact 211 can be perpendicular to
The bottom 111 of holding part 110 translates.As shown in Figure 2 A, spring contact 211 can include top section 2111, shoulder 2112 and
Compresses lower section 2113.Shoulder 2112 and compresses lower section 2113 are positioned at described stroke space 213, and this shoulder 2112 can be at stroke
Being engaged in the peripheral part limiting this opening 214 in space, top section 2111 extends opening 214, bottom from shoulder 2112
Section 2113 extends towards stroke space is internal from shoulder.Elastic device can be set between bottom compresses lower section 2113 and stroke space
Part 216, such as, helical spring.When top section 2111 is by contact pressure F 1 straight down, spring contact 211 can gram
Taking the restoring force of spring 216 and pan-down, shoulder 2112 departs from the joint of the peripheral part with hole 214.When pressure F discharges
Time, spring contact 211 can reset under the effect of the restoring force of spring 216.Contact probe 210 entirety can be by metal material system
Become.The quantity of contact probe 210 and position thereof correspond to quantity and the position thereof of the electrode 91 bottom orifice plate 9.
Probe module 200 can also include that at least one switchs probe 220, as shown in Figure 3.Switch probe 220 is also arranged in
On electrical insulating board 230, such as, worn by interference fit, and its one end can include that the bottom 111 being perpendicular to holding part 110 is flat
The elastic press section 221 moved, and the other end has the terminal 225 being electrically connected to keeper control circuit.Switch the interior of probe 220
Portion's structure can be similar to the internal structure of contact probe 210.Fig. 5 also schematically shows orifice plate 9, and is arranged at orifice plate 9
Bottom on electrode 91.When orifice plate 9 is received in holding part 110, the bullet of the bottom abutment contact probe 210 of orifice plate 9
Property the contact 211 and elastic press section 221 of switch probe 220, meanwhile, spring contact 211 is electrically connected to the electricity on bottom orifice plate 9
Pole 91.
Contact probe 210 can have stroke is preferably used, and this is preferably used the 60% to 70% of stroke for example, total kilometres,
Especially, in 2/3rds positions of the total kilometres of contact probe 210, contact probe has an optimum performance state, now, and its
Elastic force, the electrical contact situation of inner body, service life are in comprehensive optimum state.In order to make contact probe 210 always exist
It is preferably used work in stroke, and according to preferred embodiment, switch probe 220 can detect whether contact probe 210 is in it
It is preferably used in stroke.Specifically, (it is greater than or equal to switch probe when switch probe 220 is pressed next triggering stroke
The 60% of total kilometres) time, just can trigger it and disconnect or on-state.Can the connecting and disconnecting situation of testing circuit, to know out
Close probe whether be pressed down to trigger stroke, it can thus be appreciated that whether contact probe is depressed into, and stroke is preferably used.
Probe module 200 can include multiple switch probe 220, such as two, three, four, the most.Preferably,
Keeper 10 can be provided with four switch probes 220 altogether, such as, be respectively arranged at the corner portion of holding part 110 so that work as hole
Held stationary when plate 9 is placed on that in holding part, pressure change-over panel is non-depressed.When normality, all switch probe 220 is in disconnected
Open state, when pressing plate 9 is pressed down against contact probe 210 and switch probe 220 by power F2, all switch probe 220 is connected,
Keeper control circuit is just switched on, and is therefore prevented from circuit accidental switch and carries out invalid detection.
Returning Fig. 1, keeper main body 100 can be made up of metal material.Additionally, the holding part 110 of keeper main body 100 can
Including accommodate orifice plate box body 112, its periphery matches with the peripheral shape of orifice plate 9 so that orifice plate 9 be prone to place and taking-up and
Limit its level to slide.This box body 112 can be made up of metal material, and electrical insulating board 230 may be provided at the bottom of this box body 112
On.Now, the bottom of box body 112 is provided with breach (not shown), contact probe 210 and switch probe 220 and metal case
112 contactlessly by described breach.
Further, keeper 10 can include the keeper rotated around first axle X1-X1 relative to keeper main body 100
Renovating 300, such as, it is made up of metal material.Keeper renovates 300 can be attached to keeper main body by articulated elements 301
100, thus rotatable relative.Keeper is renovated 300 and can be covered above holding part 110.Articulated elements 301 can be such as damping
Type loose-leaf, it is allowed to keeper is renovated 300 and rested on its any position of rotation without free-falling, it is to avoid orifice plate 9 is caused meaning
Outer impact.
Keeping structure 1 can also include pressure change-over panel 20, it is the most also made up of metal material.At the example shown in Fig. 1
In, this pressure change-over panel 20 may be installed keeper and renovates on 300.When orifice plate 9 is received in holding part 110, orifice plate 9
Between the bottom 111 of pressure change-over panel 20 and holding part 110.Pressure change-over panel 20 can be rotatable around its axis of symmetry A-A
Be arranged on keeper and renovate on 300, this axis of symmetry A-A can be parallel to keeper and renovate 300 relative to keeper main body 100
Rotate around first axle X1-X1.Can have renovate hollow open 302 as it is shown in figure 1, keeper renovates 300, pressure is changed
Plate 20 can be received in this and renovate in hollow open.The rotation that pressure change-over panel 20 renovates 300 relative to keeper can be passed through such as
Under type realizes (Figure 17 A), and the Liang Ge edge being perpendicular to axis of symmetry A-A at pressure change-over panel 20 is provided with along axis of symmetry
The outward extending axle of line A-A 21, two axles 21 are arranged on keeper and renovate (not shown) on the corresponding axle bed of 300.Such as Figure 17 A institute
Showing, pressure change-over panel 20 can have hollow window 23, it is allowed to carries out automatic sample.
Fig. 4 shows the schematic diagram being arranged on the operation principle that pressure change-over panel 20 on 300 renovated by keeper.Such as Fig. 4
Shown in, and combine Fig. 1, when keeper renovate 300 rotate towards orifice plate 9 around first axle X1-X1 time, pressure change-over panel 20 can be first
The first edge 92 of the close first axle X1-X1 of contact orifice plate 9, now, owing to pressure change-over panel 20 can turn over relative to keeper
Lid 200 rotation, and the power making orifice plate 9 move down can not be produced, when 200 continuation rotation renovated by keeper, pressure change-over panel
20 directions indicated along arrow D around axis of symmetry A-A against the edge 92 of orifice plate 9 rotate, the hole until pressure change-over panel 20 is fitted
The upper surface of plate 9.When 200 continuation rotation renovated by keeper, pressure change-over panel 20 can apply uniform and substantially vertical to orifice plate 9
Power (as shown in power F2 in Fig. 3) in the upper surface of orifice plate 9, i.e. the direction of this power is roughly parallel to the elasticity of contact probe 210
The direction of elastic press section 211 translation of contact 211 and switch probe 220.
In the example shown in Fig. 1-3, holding part 110 can receive the rectangle orifice plate 9 in 96 holes, and pressure change-over panel 20 can have
The form of flattened rectangular framework, when 300 Guan Bi renovated by keeper, the periphery of pressure change-over panel 20 can be pressed against the surrounding of orifice plate 9.
The 300 rotation retention devices that can also include cooperating renovated by pressure change-over panel 20 and keeper.Such as, at pressure
Being parallel on the edge of axis of symmetry A-A of change-over panel 20 can be provided with pin 22 (as shown in Figure 17 A), and pin 22 can be from described
The outside projection in edge.Correspondingly, renovate the position corresponding with pin 22 of 300 at keeper and can be provided with recess 303 (figure
6), pin 22 is engageable in described recess 303.Preferably, the pressure change-over panel 20 of rectangle can be parallel to axis of symmetry A-A
Two edges on be both provided with pin 22.The rotation retention device with fit form can have other shapes apart from the above
Formula, and may also be arranged on keeper and renovate other positions of 300 and pressure change-over panel 20, as long as it is relative to realize pressure change-over panel 20
The rotating against of limited angle of 300 is renovated in keeper.Rotate arranging of retention device can avoid turning at keeper
The accidental impact to orifice plate 9 that lid 300 is likely to be due to rotating freely of pressure change-over panel 20 during being rotated down and causes
And damage.
Additionally, in order to make orifice plate 9 be correctly received in holding part 110 and be held in place, can on pressure change-over panel 20
Being additionally provided with positioner, such as, locating dowel 24 (Fig. 6), described locating dowel 24 is also error prevention device.It is rectangular opening at orifice plate 9
In the case of plate, locating dowel 24 may be provided at the top corner part office of pressure change-over panel 20, such as two adjacent top corner portion
Place, as shown in Figure 6.Locating dowel 24 can be approximately perpendicular to pressure change-over panel 20 and extend along the direction towards orifice plate 9 upper surface, i.e.
When 300 Guan Bi renovated by keeper, locating dowel 23 extends towards holding part 110.Correspondingly, the corresponding position at orifice plate 9 can
Being provided with cut-out, when 300 Guan Bi renovated by keeper, locating dowel 24 can be received in the corresponding cut-out of orifice plate 9.
Cut-out such as can have the shape such as rectangle, triangle.In the detection, the sample to be detected in each hole of orifice plate 9 and inspection
It is different for surveying purpose, and therefore, orifice plate 9 must be received in holding part 110 with preset bearing, when orifice plate 9 orientation is wrong
Mistaking, keeper is renovated 300 and can not be closed.Therefore ensure that being properly positioned and safety installation of orifice plate 9, it is to avoid produce any connection
Mistake and the invalid detection thereby resulted in.The quantity of locating dowel 24 is necessarily two, and it can be other quantity, such as one
Or three, and the position of locating dowel 24 also need not as shown in Figure 6, as long as can ensure that orifice plate 9 is properly positioned.
Fig. 5 is the top view of the holding structure 1 shown in Fig. 1, and wherein, 300 Guan Bis renovated by the keeper of keeper 10.Figure
6 is the top view of the holding structure 1 shown in Fig. 1, and wherein the keeper of keeper 10 is renovated 300 and opened.As it can be seen, keep
Device renovates 300 can also include handle 303 and the snap close 304 that can rotate relative to this handle 303, and handle 303 and snap close 304 can set
Put at the free edge relative with articulated elements 301 that keeper renovates 300.Correspondingly, keeper main body 100 can be provided with
The snap close fixture 101 that snap close 304 coordinates, to renovate 300 and keeper main body when 300 Guan Bi renovated by keeper by keeper
100 lockings, thus orifice plate 9 is pressed on wherein so that the electrode 91 of orifice plate 9 consolidates with the spring contact 211 of contact probe 210
Contact.Preferably, can be provided with sensor (invisible to operator) in snap close fixture 101, this sensor is connected to
Controller and can to controller send signal.When snap close 304 and snap close fixture 101 correctly snap close and when locking, sensor
Sending instruction keeper to controller and renovate the signal that 300 Guan Bis put in place, now, controller could start detection process.
Such as Fig. 1, as shown in 5 and 6, keeper main body 100 can be additionally provided with groove 104, and it is positioned at keeper main body 100
In upper surface.Groove 104 may be about the annular groove of holding part 110, can be provided with sealing member, such as, fluid sealant in it
Circle 105.When keeper main body 100 is arranged in the cabinet of detector, the table top of cabinet is by this sealing member and keeper master
Body 100 seals to be installed.
Fig. 7 shows the axonometric chart observed from below of keeper main body 1.Keeper main body 100 can include keeper master
Pillar body 102, for being supported on keeper 10 in the cabinet of detector.Keeper main body 100 can also include being arranged at holding
Shielding box 120 on the bottom of device main body 100.This shielding box 120 can be made up of metal material, has parallelepiped shape,
The bottom of keeper main body 100 is opened wide and be fixed at this open side in one side of shielding box 120, such as by opening wide
The edge 121 that projects outwardly of of side surrounding fixes.The panel of carrying holder control circuit, such as, printed circuit board (PCB),
May be provided at this shielding box 120 internal.Contact probe 210 and switch probe 220 may pass through the welding hole on panel, and pass through
Weld and be fixed on panel, be achieved in the electrical connection of they and keeper control circuit.
At least one hole, such as, four holes as shown in Figure 7 can be provided with on other sides of shielding box 120
122, the lower terminal 225 of a switch probe is passed from each hole 122.
Fig. 8-11 shows the schematic diagram of holding structure 1 ' according to the second embodiment of the present invention.This holding structure 1 ' is used
In the another kind of orifice plate 9 ' that holding is different from the orifice plate 9 in first embodiment, such as, there is the orifice plate 9 ' in 16 holes.This holding is tied
Structure ' 1 can include keeper 10 '.This keeper 10 ' can include keeper main body 100 ', and it has and is able to receive that the accommodating of orifice plate
Portion 110 '.Keeper 10 ' can also include at least one probe module 200, is arranged at the bottom 111 ' of holding part 110 '.Probe mould
The structure of block 200 can be similar to according to a first embodiment of the present invention in the structure of probe module 200, but contact probe 210
Quantity and position are arranged for orifice plate 9 '.
In this embodiment, keeper main body 100 ' can be made up of metal material.Additionally, keeper main body 100 ' is accommodating
Portion 110 ' can include the box body 112 ' accommodating orifice plate, such as, be made up of metal material.Electrical insulating board 230 may be provided at this box body
On the bottom of 112 ', bottom is provided with breach, contact probe 210 and switch probe 220 with metal case 112 ' contactlessly
By described breach.
Below in conjunction with Fig. 1,8 and 9, holding part 110 is described.Holding part 110,110 ' can include orifice plate close to space 113,
113 ' (being indicated by dotted line frame), it is allowed to the finger of operator is inserted, easily to place and to take out orifice plate 9 and 9 '.?
In the example of Fig. 1, orifice plate is arranged on the both sides on the long limit of 96 orifice plates 9 and placed in the middle close to space 113；In the example of Fig. 8 and 9,
Orifice plate is arranged on the both sides on the long limit of 16 orifice plates 9 ' and placed in the middle close to space 113 '.But the long limit of 16 orifice plates 9 ' is approximately perpendicular to 96
The long limit of orifice plate 9.Thus, what the present invention provided that different orifice plates (such as 96 orifice plate 9 and 16 orifice plate 9 ') can share by one is accommodating
Portion 110,110 '.When shared holding part 110,110 ' receives orifice plate (such as 96 orifice plate 9) of the first kind, orifice plate is close to empty
Between 113 ' occupied by the orifice plate of the first kind；When shared holding part 110,110 ' receives orifice plate (such as 16 holes of Second Type
Plate 9 ') time, orifice plate is occupied close to space 113 by the orifice plate of Second Type, especially, for the probe mould of Second Type orifice plate 9 '
Block 200 may be provided at the orifice plate for first kind orifice plate 9 close to (Fig. 9) in space 13.The holding part 110,110 ' shared is permitted
Permitted first produce the parts with same shape, further according to its for different orifice plates and carry out different settings, such as probe
The position of module, the position etc. of bottom notch, thus save material and cost.
As shown in FIG. 8 and 9, the most identical with first embodiment, pressure change-over panel 20 ' may be provided at keeper and renovates 300 '
In hollow open, but its shape is different from the pressure change-over panel 20 in first embodiment, and is adapted for the orifice plate of Second Type, example
Such as 16 orifice plates 9 '.
Also show the panel 130 of carrying holder control circuit in Figure 11, it is positioned at below electrical insulating board 230, and
Internal at shielding box 120 '.Switch probe 220 is solderable thereon.
Figure 12 shows the axonometric chart of the first embodiment of the detector 8 according to the present invention.Figure 13 shows in Figure 12
The structure of the cabinet 80 of detector 8, wherein, keeps structure 1 or 1 ' it is removed.Detector 8 is for liquid biopsy noinvasive gene
Accurate detection, such as, in clinical or PAL, detected the epidermis of cancer patient by detection human body fluid
Growth factor receptor mutations.Detector 8 can include cabinet 80 and implementing according to the present invention first of being contained in this cabinet 80
The holding structure 1 of example.This cabinet 80 can accommodate holding structure 1 ' according to a second embodiment of the present invention equally.Specifically, cabinet
80 can include chassis lid 810 and the casing 820 opened wide in top side, and chassis lid 810 can be such as the most attached by articulated elements 801
It is connected to cabinet bulk 820, and cabinet bulk 820 can be closed hermetically to form airtight inner space.At the example shown in Figure 12
In, cabinet bulk 820 can have the shape of parallelepiped, but the present invention is not limited to this, and cabinet bulk 820 can be according to actual needs
And there is other suitable shape.Cabinet 80 can also include table top 830, and it can fix and be covered in the top of described cabinet bulk 820
Side, to be encircled into an internal capacity with cabinet bulk 820, is used for accommodating holding structure 1,1 ' and related electronic device, the most main
Plate etc..Table top 830 can be flat metal plate, such as, have rectangular shape, and include that table top opening 831 (such as, is positioned at table top
The central authorities of 830).When keeping structure 1 and 1 ' to be accommodated in cabinet bulk 820, its upper part is revealed from this table top opening 831
Go out.The periphery of table top 830 is sealably fixed to the sidepiece of casing 22.Chassis lid 810 and cabinet bulk 820 also can be by metals
Material is made, to shield electromagnetic interference.
Observation window 811 can be provided with on chassis lid 810, to observe orifice plate 9 or 9 at any time ' state.But on chassis lid 810
Also observation window 811 can be not provided with, but the single metal parts of entirety, to strengthen effectiveness.At cabinet bulk 820
Appropriate position can be additionally provided with on and off switch 821 and display lamp 822, such as, be used for indicating different operating situation, instruction orifice plate
Laying state etc..As shown in Figure 13, the bottom of cabinet bulk 820 can be provided with the multiple keeper pillars 821 extended inward
(only illustrating one in figure), for for supporting keeper 10 and be maintained in cabinet bulk 820.
Referring now to Figure 14, that schematically shows holding structure 1 or 1 ' how to be accommodated in cabinet bulk 820 and
Sealing engagement is formed with table top 830.When keeper 1,1 ' is placed in cabinet bulk 820, the keeper of keeper 10,10 '
Groove 104 in main body 100,100 ' is engaged with table top 830 by the sealing member 105 being disposed therein.Sealing member 105, such as
O-ring seal, may be provided at inside the vertical wall of table top 830 and between a sidewall of groove 104, be achieved in keeper 10,
10 ' with the sealing engagement of cabinet 80, effectively prevent the interference of the external environment condition parts to being arranged on cabinet inside.
Figure 15 A and 16 shows the 3rd embodiment 1 of the storage configuration according to the present invention " keeper 10 " schematic diagram.
Keeper 10 " keeper main body 100 can be included ", it has the holding part 110 being able to receive that orifice plate ".Keeper 10 " can also wrap
Include at least one probe module 200 ", be arranged at holding part 110 " bottom 111 ".With the storage configuration 1 according to the present invention
Probe module in one embodiment 200 is similar to, probe module 200 " can include multiple contact probe 210, at least one switch spy
Pin 220 and electrical insulating board 230.Contact probe 210 can be identical, the most not with describe before with the structure switching probe 220
Repeat again.
As shown in fig. 15, this keeper 10 " not there is keeper renovate.Keep structure 1 " can also include pressure change-over panel
20 ", such as, it is made up of metal material, this pressure change-over panel 20 " on the chassis lid 810A of the cabinet 80A that is arranged on detector 8A
(Figure 18 and Figure 19).This will be explained below.
Holding part 110 " fence 140 can be included, described fence 140 can be from holding part 110 " bottom 111 " outwardly,
With around orifice plate 9 and limit its level slide.Figure 15 B shows that two of fence 140 may form.But the form of fence 140
It is not limited in the example shown in figure.
Holding part 110 " it is electric insulation, and be integral with electrical insulating board 230.This keeper main body 100 " overall permissible
It is electric insulation, such as, is made up of plastic material.Keeper main body 100 " can also include closed circular wall 150, from keeper master
Body 100 " outwardly and be positioned at the periphery of fence 140.This closed circular wall 150 can carry sealing member 151, such as fluid sealant
Circle.As shown in figure 15 a, keeper main body 100 " can also include mistake proofing column 141, it is arranged on holding part 110 " bottom, and
From holding part 110 " outwardly.In order to make orifice plate 9 or 9 ' be received in holding part 110 with predetermined direction " in, at orifice plate 9 or
The corresponding position of 9 ' bottoms can be provided with the recess for receiving mistake proofing column 141, remainder then general planar.Work as hole
When plate is placed with the direction different from predetermined direction, the recess bottom it can not engage mistake proofing column 141, thus can not be to moving down
Dynamic, now, it is the state tilted that operator can be observed orifice plate.
Figure 16 shows the keeper 10 observed from below ".Keeper 10 " can also include supporting keeper main body 100 "
Gripper shoe 400, gripper shoe 400 can be located at keeper main body 100 " lower section, be such as fixed to keeper main body 100 " bottom,
And be made up of metal material, strengthen the structural strength of keeper the most further, electromagnetic shielding is provided simultaneously.Gripper shoe 400 can
Being provided with breach 401, contact probe 210 and switch probe 220 can be with gripper shoe 400 contactlessly through breach 401.Gripper shoe
400 can have towards keeper main body 100 " the first side (not shown) and the second side 402 of the most described keeper main body,
The panel 130 of carrying holder control circuit " (Figure 19) be fixed in the second side 402 of gripper shoe 400 gripper shoe 400 and with
Gripper shoe 400 is spaced apart.
Below in conjunction with Figure 18 and 19 describe keep structure 1 " pressure change-over panel 20 ".Figure 18 and 19 shows according to this
Second embodiment 8A of the detector of invention.As it can be seen, detector 8A can include that cabinet 80A, cabinet 80A can include chassis lid
810A and cabinet bulk 820A.When orifice plate is received in holding part 110 " in time, orifice plate is positioned at pressure change-over panel 20 " and holding part
110 " bottom 111 " between.Pressure change-over panel 20 " chassis lid 810A can be rotatably installed in around its axis of symmetry A-A
On, such as by its axle 21 " (Figure 17 B).This axis of symmetry A-A can be parallel to chassis lid 810A and rotate relative to cabinet bulk 820A
Around the second axis X 2-X2.Especially, chassis lid 810A can have receiving portion 811A, pressure change-over panel 20 " it is received in
In receiving portion 811A.Pressure change-over panel 20 " structure can as seen in this fig. 17b, it can have the form of rectangular frame, but permissible
It not flat rectangular frame, but there is compared with the pressure change-over panel 20 in first embodiment thicker thickness, to adapt to
There is the chassis lid 80A of greater thicknesses.Pressure change-over panel 20 " operation principle identical with pressure change-over panel 20, the most no longer
Repeat.When chassis lid 810A closes, pressure change-over panel 20 " periphery can be pressed against orifice plate 9 or 9 ' surrounding.
Pressure change-over panel 20 " and chassis lid 810A can also include the rotation retention device that cooperates.Such as, turn at pressure
Change plate 20 " be parallel on the edge of axis of symmetry A-A can be provided with pin 22 ", pin 22 " can be from described edge to evagination
Stretch.Correspondingly, chassis lid 810A includes lever receiving portion 812A (Figure 19).The rotation retention device with fit form can have
Have other forms in addition to those described above, and may also be arranged on chassis lid 810A and pressure change-over panel 20 " other positions, only
Pressure change-over panel 20 to be realized " the rotating against of limited angle relative to chassis lid 810A.
On and off switch 821A and display lamp 822A can be provided with on cabinet bulk 820A.
Detector 8A can also include panel 830A, its e.g. metal decking.As shown in figure 19, cabinet bulk 820A can include
First shielding case 823A, secondary shielding shell 824A and the 3rd shielding case 825A, they are metal shielding.First shielding case
823A is around keeper 10 " arrange, by keeper main body 100 ", probe module 200 ", the control of carrying holder control circuit
Plate 130 etc. is surrounded in it.Secondary shielding shell 824A and the 3rd shielding case 825A surrounds the first shielding case 823A and detector
Master board 81A this master board 81A of 8A is positioned at outside the first shielding case 823A.Thus, by metal decking 830A, keeper
Gripper shoe the 400, first shielding case 823A, secondary shielding shell 824A and the 3rd shielding case 825A may make up box-like shield, effectively
Ground carries out electromagnetic shielding to the local current path on panel and probe.
When chassis lid 810A closes, inside it, be pressed against keeper main body 100 " on closed circular wall 150 carried
Sealing member 151, it is achieved the sealing engagement between keeper and cabinet 80A.
Figure 20 shows an embodiment of detector 8A, it holding knot including receiving the orifice plate 9 ' in three 16 holes
Structure.Correspondingly, chassis lid 810A can be provided with three pressure change-over panels 20 " '.
Figure 21 shows another embodiment of detector 8A, it holding knot including receiving the orifice plate 9 ' in 16 holes
Structure.Correspondingly, chassis lid 810A can be provided with a pressure change-over panel 20 " '.
Although the better model performing the present invention having been carried out detailed description, but those skilled in the art can having obtained
Know many replacement designs and embodiment for implementing the present invention within the scope of the appended claims.
Claims (22)
1., for keeping a holding structure for pattern detection orifice plate, described orifice plate is with electrode and accommodates sample, and its feature exists
In, this holding structure includes keeper and pressure change-over panel, and described keeper includes:
Keeper main body, has the holding part receiving described orifice plate；With
At least one probe module, is arranged at the bottom of described holding part, and described probe module includes:
Multiple contact probes, spring contact that one end of described contact probe includes being perpendicular to the bottom translation of described holding part and
The other end is electrically connected to keeper control circuit；
At least one switchs probe, one end of described switch probe include the elasticity being perpendicular to the bottom translation of described holding part by
Splenium and the other end are electrically connected to keeper control circuit；With
Electrical insulating board, described contact probe and described switch probe are located on described electrical insulating board；
Wherein, when described orifice plate is received in described holding part, the bullet of contact probe described in the bottom abutment of described orifice plate
Property contact and the elastic press section of described switch probe, described spring contact is electrically connected to be arranged on the bottom of described orifice plate
Electrode, and described orifice plate is between described pressure change-over panel and the bottom of described holding part.
Keep structure the most as claimed in claim 1, it is characterised in that described pressure change-over panel is rotatable around the one axis of symmetry
Ground is installed.
Keep structure the most as claimed in claim 2, it is characterised in that described keeper includes around first axle relative to described
The keeper that keeper main body rotates is renovated, and described pressure change-over panel is arranged on described keeper and renovates, and described pressure turns
Change plate rotate around the axis of symmetry be parallel to described first axle.
Keep structure the most as claimed in claim 3, it is characterised in that described keeper is renovated to have and renovated hollow open, institute
State pressure change-over panel be received in described in renovate in hollow open.
Keep structure the most as claimed in claim 3, it is characterised in that setting renovated by described pressure change-over panel and described keeper
There is the rotation retention device cooperated.
Keep structure the most as claimed in claim 3, it is characterised in that described pressure change-over panel has makes described orifice plate position
Positioner.
Keep structure the most as claimed in claim 2, it is characterised in that it is a part for detector, described pressure change-over panel
It is arranged on the chassis lid of detector.
Keep structure the most as claimed in claim 7, it is characterised in that the chassis lid of detector relative to cabinet bulk around the second axle
Line rotates and has receiving portion, and described pressure change-over panel is received in described receiving portion, and the rotation of described pressure change-over panel
Turn around the axis of symmetry be parallel to described second axis.
Keep structure the most as claimed in claim 6, it is characterised in that described pressure change-over panel and described chassis lid are provided with phase
The rotation retention device coordinated mutually.
Keep structure the most as claimed in any one of claims 1-9 wherein, it is characterised in that described pressure change-over panel is hollow square
The form of shape framework.
11. keep structure as claimed in claim 1, it is characterised in that described holding part includes fence, and described fence is from described
The bottom of holding part is outwardly with around described orifice plate, and described holding part is electric insulation and becomes one with described electrical insulating board
Body.
12. keep structure as claimed in claim 11, it is characterised in that described keeper main body includes closed circular wall, institute
Stating closed circular wall from described keeper main body outwardly, and be positioned at the periphery of described fence, described closed circular wall carries
There is sealing member.
13. keep structure as claimed in claim 11, it is characterised in that described keeper also includes supporting described keeper master
The gripper shoe of body, described gripper shoe includes that breach, described contact probe and described switch probe are with described gripper shoe contactlessly
Through described breach.
14. keep structure as claimed in claim 13, it is characterised in that described gripper shoe is positioned under described keeper main body
Side, and there is the first side towards described keeper main body and the second side of the most described keeper main body, described gripper shoe
Being fixed to described keeper main body, the panel carrying described keeper control circuit is fixed in the second side of described gripper shoe
Described gripper shoe is the most spaced apart with described gripper shoe.
The 15. holding structures as described in claim 13 or 14, it is characterised in that described gripper shoe is made up of metal material.
16. keep structure as claimed in claim 1, it is characterised in that described holding part includes the box body accommodating described orifice plate,
Described electrical insulating board is arranged on the bottom of described box body.
17. keep structure as claimed in claim 16, it is characterised in that described keeper main body is made up of metal material.
18. keep structure as claimed in claim 16, it is characterised in that described holding part also includes that orifice plate is close to space.
19. keep structure as claimed in claim 1, it is characterised in that described probe module includes multiple switch probe.
20. keep structure as claimed in claim 1, it is characterised in that described switch probe is normal open switch.
21. keep structure as claimed in claim 6, it is characterised in that be provided with for described orifice plate bottom described holding part
Error prevention device.
22. 1 kinds of detectors, it is characterised in that it includes the holding structure as according to any one of claim 1-21 and machine
Case.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610658321.XA CN106290476B (en) | 2016-08-11 | 2016-08-11 | Keep structure and the detector including keeping structure |
| PCT/CN2017/105434 WO2018028722A2 (en) | 2016-08-11 | 2017-10-10 | Holding structure and detector comprising holding structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610658321.XA CN106290476B (en) | 2016-08-11 | 2016-08-11 | Keep structure and the detector including keeping structure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106290476A true CN106290476A (en) | 2017-01-04 |
| CN106290476B CN106290476B (en) | 2019-06-07 |
Family
ID=57669551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610658321.XA Expired - Fee Related CN106290476B (en) | 2016-08-11 | 2016-08-11 | Keep structure and the detector including keeping structure |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106290476B (en) |
| WO (1) | WO2018028722A2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018028722A3 (en) * | 2016-08-11 | 2018-04-12 | 广州易活生物科技有限公司 | Holding structure and detector comprising holding structure |
| CN110118803A (en) * | 2018-02-07 | 2019-08-13 | 北京易活生物科技有限公司 | Sample testing apparatus |
| CN110806309A (en) * | 2018-08-03 | 2020-02-18 | 施耐德电器工业公司 | Testing device for contactor |
| CN112992599A (en) * | 2019-12-13 | 2021-06-18 | 天津平高智能电气有限公司 | Vacuum arc-extinguishing chamber vacuum degree measuring device |
| CN114785427A (en) * | 2022-03-09 | 2022-07-22 | 昆山浩兴电子科技有限公司 | Portable WIFI signal detection device |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112680322B (en) * | 2021-01-29 | 2022-09-16 | 青岛汉唐生物科技有限公司 | Supplementary application of sample and tectorial membrane device |
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| CN1811619A (en) * | 2005-01-26 | 2006-08-02 | 精工爱普生株式会社 | Timepiece movement holding structure and timepiece |
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| CN201194023Y (en) * | 2008-04-07 | 2009-02-11 | 比亚迪股份有限公司 | Integrated circuit testing apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018028722A3 (en) * | 2016-08-11 | 2018-04-12 | 广州易活生物科技有限公司 | Holding structure and detector comprising holding structure |
| CN110118803A (en) * | 2018-02-07 | 2019-08-13 | 北京易活生物科技有限公司 | Sample testing apparatus |
| CN110806309A (en) * | 2018-08-03 | 2020-02-18 | 施耐德电器工业公司 | Testing device for contactor |
| CN110806309B (en) * | 2018-08-03 | 2022-03-08 | 施耐德电器工业公司 | Testing device for contactor |
| CN112992599A (en) * | 2019-12-13 | 2021-06-18 | 天津平高智能电气有限公司 | Vacuum arc-extinguishing chamber vacuum degree measuring device |
| CN112992599B (en) * | 2019-12-13 | 2023-02-17 | 天津平高智能电气有限公司 | Vacuum degree measuring device for vacuum arc extinguish chamber |
| CN114785427A (en) * | 2022-03-09 | 2022-07-22 | 昆山浩兴电子科技有限公司 | Portable WIFI signal detection device |
| CN114785427B (en) * | 2022-03-09 | 2024-01-30 | 昆山浩兴电子科技有限公司 | Portable WIFI signal detection device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106290476B (en) | 2019-06-07 |
| WO2018028722A3 (en) | 2018-04-12 |
| WO2018028722A2 (en) | 2018-02-15 |
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Granted publication date: 20190607 |