CN112680322B - Supplementary application of sample and tectorial membrane device - Google Patents
Supplementary application of sample and tectorial membrane device Download PDFInfo
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- CN112680322B CN112680322B CN202110122045.6A CN202110122045A CN112680322B CN 112680322 B CN112680322 B CN 112680322B CN 202110122045 A CN202110122045 A CN 202110122045A CN 112680322 B CN112680322 B CN 112680322B
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Abstract
The invention provides an auxiliary sample adding and film laminating device which comprises a first support and a second support, wherein the first support and the second support are hinged, the first support and the second support can be opened or closed around the hinged part, the interiors of the first support and the second support are of hollow structures communicated with the outside, the second support is provided with a first sliding part and a second sliding part which can slide in a reciprocating manner, the sliding direction of the first sliding part is vertical to that of the second sliding part, and the first sliding part and the second sliding part are arranged in a vertical crossing manner; the device can avoid the occurrence of missing loading, wrong loading or repeated loading of a 96-deep-hole plate sample matched with the automatic nucleic acid extractor, and improve the working efficiency and the accuracy; the device can realize sealing, prevent pollution, avoid the infection of operators and realize the purpose of accurate, efficient and safe experiments.
Description
Technical Field
The invention relates to the field of molecular biology experimental equipment, in particular to an auxiliary sample adding and film covering device suitable for a 96-deep-hole plate.
Background
Along with the development of nucleic acid detection technology, the demand of units such as hospitals, disease control centers and the like on automatic nucleic acid extraction is gradually increased, the automatic nucleic acid extraction is an important step for improving the nucleic acid detection efficiency, the speed and the accuracy of the automatic nucleic acid extraction directly influence the efficiency of a nucleic acid detection report, and the anti-pollution operation after sample adding and extraction is concerned with the personal safety of experiment operators.
The automatic nucleic acid extraction is completed by an automatic nucleic acid extractor, a 96-deep-well plate used by the automatic nucleic acid extractor consists of 12 transverse rows of holes and 8 longitudinal rows of holes, and in clinical practical operation, the original marks on the deep-well plate are not convenient for distinguishing the positions of the holes, and errors of missing adding, wrong adding or repeated adding of the samples occur, so that the interpretation of detection results is seriously influenced; if sealing is not done after sample adding and extraction, accidents such as operator infection and the like can be caused.
Disclosure of Invention
The invention aims to overcome the defects of the traditional technology and provide an auxiliary sample adding and film coating device, which can avoid the occurrence of missing, wrong or repeated sample adding of a 96-deep-hole plate sample matched with an automatic nucleic acid extractor, improve the working efficiency and accuracy, realize sealing, prevent pollution and avoid the infection of operators.
The purpose of the invention is achieved by the following technical measures:
the utility model provides an auxiliary sample adding and film covering device, includes first support and second support, first support and second support are articulated, first support and second support can be opened or close around articulated department, the inside hollow structure who communicates with the external world of being of first support and second support, first sliding part and the second sliding part that has the reciprocal slip on the second support, the slip direction of first sliding part is mutually perpendicular with the slip direction of second sliding part, first sliding part and second sliding part cross arrangement from top to bottom.
As a preferable scheme, the second support is provided with two first through grooves, the two first through grooves are arranged oppositely, one end of the first sliding component is connected with one of the first through grooves, the other end of the first sliding component is connected with the other first through groove, and the first sliding component slides back and forth along the first through groove.
Preferably, the first through groove is rectangular, and two ends of the first sliding member pass through the first through groove and are located outside the second bracket.
Preferably, the first slide member has an elongated shape, and a cross-sectional shape thereof is rectangular, circular or elliptical.
As a preferable scheme, the second support is provided with two second through grooves, the two second through grooves are arranged oppositely, one end of the second sliding component is connected with one of the second through grooves, the other end of the second sliding component is connected with the other second through groove, and the second sliding component slides back and forth along the second through groove.
Preferably, the second through groove is rectangular, and two ends of the second sliding member pass through the second through groove and are located outside the second bracket.
Preferably, one side of the second through groove, which is close to the first bracket, is provided with an opening, the length of the opening is equal to that of the second through groove, and the second through groove is communicated with the outside through the opening.
Preferably, the second slide member has an elongated shape, and a cross-sectional shape thereof is rectangular, circular or elliptical.
As a preferable scheme, the second support is provided with two supporting portions which are arranged oppositely, a sliding groove is formed in each supporting portion, a sliding block is arranged in each sliding groove, each sliding block is connected with a positioning column, each positioning column is connected with an elastic part, and the other end of each elastic part is connected with the second sliding part.
As a preferred scheme, the elastic component is a spring, the spring is sleeved on the positioning column, and the positioning column is provided with a positioning pin for fixing the spring.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the advantages that:
the device can avoid the occurrence of missing, wrong or repeated sample adding of 96 deep-hole plate samples matched with the automatic nucleic acid extractor, and improve the working efficiency and the accuracy
The device can realize sealing, prevent pollution, avoid the infection of operators and realize the purpose of accurate, efficient and safe experiments.
The invention is further described with reference to the following figures and detailed description.
Drawings
FIG. 1 is a schematic structural diagram of an auxiliary sample adding and film covering device according to the present invention.
Fig. 2 is a bottom view of fig. 1 of the present invention.
Fig. 3 is a right side view of fig. 1 of the present invention.
Fig. 4 is a top view of fig. 1 of the present invention.
FIG. 5 is a perspective view of an auxiliary sample application and film coating device according to the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the equipment or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
Example (b): as shown in fig. 1-5, an auxiliary sample adding and film covering device comprises a first support 12 and a second support 1, wherein the upper surface of the first support 12 contacts the lower surface of the second support 1, the first support 12 and the second support 1 are both rectangular, the first support 12 and the second support 1 are of frame structures, the interiors of the first support 12 and the second support 1 are of hollow structures communicated with the outside, a through hole which is communicated up and down is formed between the first support 12 and the second support 1, the through hole is also rectangular in shape, the first support 12 is hinged with the second support 1, the first support 12 and the second support 1 can be opened or closed around the hinged part, one end of the first support 12 is connected with one end of the second support 1 through a hinge 3, or other connection modes can be adopted as required, the second support 1 is provided with a first sliding part 2 and a second sliding part 7 which can slide back and forth, the sliding direction of the first sliding member 2 is perpendicular to the sliding direction of the second sliding member 7, the first sliding member 2 and the second sliding member 7 are arranged to intersect vertically, the first sliding member 2 and the second sliding member 7 are arranged to be perpendicular to each other, and the first sliding member 2 is positioned above the second sliding member 7.
Be provided with first logical groove 8 on the second support 1, first logical groove 8 is along the horizontal extension of second support 1, the quantity that first logical groove 8 was two, and two first logical grooves 8 set up relatively, and two first logical grooves 8 are located the both ends of second support 1, wherein one end of first sliding part 2 is connected with one of them first logical groove 8, the other end and the other one first logical groove 8 of first sliding part 2 are connected, first sliding part 2 is followed first logical groove 8 and is reciprocated sliding.
The first through groove 8 is rectangular, and both ends of the first sliding member 2 pass through the first through groove 8 and are located outside the second bracket 1.
The first slide member 2 is shaped like a long bar, and the cross section thereof is rectangular, or may be shaped like a circle or an ellipse as needed, and the height of the first through groove 8 is larger than the thickness of the first slide member 2.
The second bracket 1 is provided with two through grooves 13, the second through grooves 13 extend along the longitudinal direction of the second bracket 1, the number of the second through grooves 13 is two, the two second through grooves 13 are oppositely arranged, the two second through grooves 13 are positioned on two sides of the second bracket 1, one end of the second sliding component 7 is connected with one of the second through grooves 13, the other end of the second sliding component 7 is connected with the other second through groove 13, and the second sliding component 7 slides back and forth along the second through grooves 13.
The second through groove 13 is rectangular, and both ends of the second sliding member 7 pass through the second through groove 13 and are located outside the second bracket 1.
One side of the second through groove 13, which is close to the first bracket 12, is provided with an opening, the length of the opening is equal to that of the second through groove 13, and the second through groove 13 is communicated with the outside through the opening.
The second slide member 7 is elongated and has a rectangular cross section, and may have a circular or elliptical shape as needed, and the height of the second through groove 13 is larger than the thickness of the second slide member 7.
The second support 1 is provided with two supporting parts 4 which are arranged oppositely, the supporting parts 4 are located on the upper portions of two sides of the second support 1, the supporting parts 4 extend out of the second support 1, the supporting parts 4 are rectangular, sliding grooves 5 are formed in the supporting parts 4, the sliding grooves 5 are communicated with the outside vertically, sliding blocks 6 are arranged in the sliding grooves 5, the sliding blocks 6 are connected with positioning columns 11, the positioning columns 11 extend out of the lower portions, elastic parts are connected to the positioning columns 11, and the other ends of the elastic parts are connected with the second sliding parts 7.
The elastic component is a spring 9, the spring 9 is sleeved on a positioning column 11, a positioning pin 10 for fixing the spring 9 is arranged on the positioning column 11, the positioning pin 10 is perpendicular to the positioning column 11, the positioning pins 10 are two in number, the two positioning pins 10 are symmetrically arranged, and the spring 9 is connected with the part, extending out of the second support 1, of the second sliding component 7.
The first bracket 12, the second bracket 1, the first slide member 2, and the second slide member 7 are each made of a resin material.
When in use, the first bracket 12 is aligned to four corners of the 96 deep-hole plate, so that the 96 deep-hole plate is embedded into the bracket, and then the 96 deep-hole plate and the bracket are placed on the table top of the biological safety cabinet together;
the first sliding part 2 and the second sliding part 7 are placed in the zero position, namely, in the upper left corner of the second bracket 1;
and longitudinally adding samples, sliding the first sliding part 2 once every time when adding one sample, wherein the crossed position of the first sliding part 2 and the second sliding part 7 is a sample hole to be added, after each row of samples are added, returning the first sliding part 2 to the original position, moving the second sliding part 7 to the right by one row, continuously repeating the moving mode of the first sliding part 2 for adding the samples, and sequentially repeating the sample adding.
After all samples are added, the second support 1 is opened, the sealing plate film is lightly placed on the surface of the 96-deep-hole plate, the second support 1 is buckled again, the second sliding part 7 is pressed down by force to the extension spring 9, the second sliding part 7 is made to contact with the sealing plate film and then slides to the other side, the sealing plate film is pressed tightly to prevent pollution, and after sealing is completed, the second sliding part 7 is loosened to reset under the action of the spring 9.
The invention can assist in sample adding into the 96 deep-hole plate adapted to the full-automatic extractor, the position of the hole is not convenient to distinguish by the mark carried by the 96 deep-hole plate, the errors of wrong sample adding, missing sample adding or repeated sample adding often occur, and the time cost caused by the errors seriously influences the timeliness of clinical diagnosis. The invention can accurately and efficiently finish the sample adding of the 96 deep-hole plate, reduce the error rate of the sample adding, simultaneously, the final auxiliary film covering function can press the sealing plate film more tightly, can effectively prevent the sample leakage or cross infection which can occur in the manual film sealing, and obviously improves the safety of the experiment.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (4)
1. The utility model provides an auxiliary application of sample and tectorial membrane device, includes first support (12) and second support (1), first support (12) and second support (1) are articulated, first support (12) and second support (1) can be around articulated department opening or close, its characterized in that: the inner parts of the first support (12) and the second support (1) are hollow structures communicated with the outside, the second support (1) is provided with a first sliding component (2) and a second sliding component (7) which can slide in a reciprocating manner, the sliding direction of the first sliding component (2) is vertical to that of the second sliding component (7), and the first sliding component (2) and the second sliding component (7) are arranged in a vertically crossed manner; the second support (1) is provided with two first through grooves (8), the two first through grooves (8) are arranged oppositely, one end of each first sliding component (2) is connected with one first through groove (8), the other end of each first sliding component (2) is connected with the other first through groove (8), each first sliding component (2) slides in a reciprocating mode along the corresponding first through groove (8), the first through grooves (8) are rectangular, and two ends of each first sliding component (2) penetrate through the corresponding first through groove (8) and are located outside the second support (1); the second bracket (1) is provided with two second through grooves (13), the two second through grooves (13) are arranged oppositely, one end of the second sliding component (7) is connected with one of the second through grooves (13), the other end of the second sliding component (7) is connected with the other second through groove (13), and the second sliding component (7) slides in a reciprocating manner along the second through groove (13); the second through groove (13) is rectangular, and two ends of the second sliding component (7) penetrate through the second through groove (13) and are positioned outside the second bracket (1); an opening is formed in one side, close to the first support (12), of the second through groove (13), the length of the opening is equal to that of the second through groove (13), and the second through groove (13) is communicated with the outside through the opening; the second support (1) is provided with two supporting parts (4) which are oppositely arranged, a sliding groove (5) is formed in each supporting part (4), a sliding block (6) is arranged in each sliding groove (5), each sliding block (6) is connected with a positioning column (11), each positioning column (11) is connected with an elastic part, and the other end of each elastic part is connected with a second sliding part (7).
2. The device for assisting sample application and film covering according to claim 1, wherein: the first sliding member (2) is elongated and has a rectangular, circular or oval cross-sectional shape.
3. The device for assisting sample application and film covering according to claim 1, wherein: the second slide member (7) is elongated and has a rectangular, circular or oval cross-sectional shape.
4. The device for assisting sample application and film covering according to claim 1, wherein: the elastic component is a spring (9), the spring (9) is sleeved on a positioning column (11), and a positioning pin (10) for fixing the spring (9) is arranged on the positioning column (11).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110122045.6A CN112680322B (en) | 2021-01-29 | 2021-01-29 | Supplementary application of sample and tectorial membrane device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110122045.6A CN112680322B (en) | 2021-01-29 | 2021-01-29 | Supplementary application of sample and tectorial membrane device |
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| Publication Number | Publication Date |
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| CN112680322A CN112680322A (en) | 2021-04-20 |
| CN112680322B true CN112680322B (en) | 2022-09-16 |
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| CN202110122045.6A Active CN112680322B (en) | 2021-01-29 | 2021-01-29 | Supplementary application of sample and tectorial membrane device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114955065B (en) * | 2022-05-27 | 2024-05-28 | 华安芯科技(深圳)有限公司 | Automatic transmission method of novel crown antigen detection kit |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101282841B1 (en) * | 2011-12-30 | 2013-07-05 | (주)어핀텍 | Apparatus and method for isolating nucleicacids or biological materials |
| CN104152341B (en) * | 2013-05-14 | 2016-04-27 | 上海市东方医院 | Fluorescent quantitative poly chain reaction 384 hole PCR plate coordinate application of sample box |
| CN204649762U (en) * | 2015-04-20 | 2015-09-16 | 北京市农林科学院 | A kind of locating device being applicable to 96 orifice plate application of samples |
| CN106290476B (en) * | 2016-08-11 | 2019-06-07 | 广州易活生物科技有限公司 | Keep structure and the detector including keeping structure |
| KR101888376B1 (en) * | 2017-05-12 | 2018-08-14 | 티엔에스(주) | Gene chip for diagnosing infectious diseases |
| CN109531982A (en) * | 2018-11-10 | 2019-03-29 | 芜湖华宇彩晶科技有限公司 | Squeeze-film mechanism after a kind of display screen surface overlay film |
| CN209570605U (en) * | 2019-01-31 | 2019-11-01 | 上海美丽人生医疗科技有限公司 | A kind of high-performance bio detection kit |
| CN110923114A (en) * | 2019-11-20 | 2020-03-27 | 滨州市农业农村局 | 96 supplementary application of sample sampling device of hole PCR board |
| CN211837958U (en) * | 2019-12-30 | 2020-11-03 | 石家庄金域医学检验实验室有限公司 | Micropore plate sealing device |
| CN212316091U (en) * | 2020-05-05 | 2021-01-08 | 华中科技大学同济医学院附属协和医院 | PCR application of sample monitoring devices |
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