CN106280174A - A kind of syringe jacket high intensity anti-biotic material and preparation method thereof - Google Patents

A kind of syringe jacket high intensity anti-biotic material and preparation method thereof Download PDF

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Publication number
CN106280174A
CN106280174A CN201610760861.9A CN201610760861A CN106280174A CN 106280174 A CN106280174 A CN 106280174A CN 201610760861 A CN201610760861 A CN 201610760861A CN 106280174 A CN106280174 A CN 106280174A
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parts
high intensity
syringe jacket
biotic material
intensity anti
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胡何辉
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
    • C08L33/10—Homopolymers or copolymers of methacrylic acid esters
    • C08L33/12—Homopolymers or copolymers of methyl methacrylate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/02—Making granules by dividing preformed material
    • B29B9/06—Making granules by dividing preformed material in the form of filamentary material, e.g. combined with extrusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/76—Measuring, controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/76—Measuring, controlling or regulating
    • B29C45/77—Measuring, controlling or regulating of velocity or pressure of moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/76—Measuring, controlling or regulating
    • B29C45/78—Measuring, controlling or regulating of temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/92—Measuring, controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2945/00—Indexing scheme relating to injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould
    • B29C2945/76—Measuring, controlling or regulating
    • B29C2945/76494—Controlled parameter
    • B29C2945/76498—Pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2945/00—Indexing scheme relating to injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould
    • B29C2945/76—Measuring, controlling or regulating
    • B29C2945/76494—Controlled parameter
    • B29C2945/76531—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2945/00—Indexing scheme relating to injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould
    • B29C2945/76—Measuring, controlling or regulating
    • B29C2945/76494—Controlled parameter
    • B29C2945/76551—Time
    • B29C2945/76561—Time duration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2945/00—Indexing scheme relating to injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould
    • B29C2945/76—Measuring, controlling or regulating
    • B29C2945/76494—Controlled parameter
    • B29C2945/76595—Velocity
    • B29C2945/76605—Velocity rotational movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2948/00—Indexing scheme relating to extrusion moulding
    • B29C2948/92—Measuring, controlling or regulating
    • B29C2948/92323—Location or phase of measurement
    • B29C2948/92361—Extrusion unit
    • B29C2948/9238—Feeding, melting, plasticising or pumping zones, e.g. the melt itself
    • B29C2948/9239—Screw or gear
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2948/00—Indexing scheme relating to extrusion moulding
    • B29C2948/92—Measuring, controlling or regulating
    • B29C2948/92504—Controlled parameter
    • B29C2948/9258—Velocity
    • B29C2948/9259—Angular velocity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2948/00—Indexing scheme relating to extrusion moulding
    • B29C2948/92—Measuring, controlling or regulating
    • B29C2948/92504—Controlled parameter
    • B29C2948/92704—Temperature
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
    • C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend

Abstract

The invention discloses a kind of syringe jacket high intensity anti-biotic material, be prepared by the raw materials in: polymethyl methacrylate 15 25 parts, polyether-tribasic alcohol 10 15 parts, polyglycolic acid 5 10 parts, polyether sulfone 37 parts, glass fibre 38 parts, acetate fiber 5 12 parts, trisodium citrate 58 parts, sulfadiazine 35 parts, ethambutol 58 parts, glycine betaine 36 parts, "Antifungin". 26 parts, ethyl benzoic acid 24 parts, 47 parts of firming agent, stabilizer 38 parts, catalyst 13 parts.The syringe jacket high intensity anti-biotic material being prepared from, its stable performance, intensity height, there is antibacterial functions.Meanwhile, the preparation method of this syringe jacket high intensity anti-biotic material is also disclosed.

Description

A kind of syringe jacket high intensity anti-biotic material and preparation method thereof
Technical field
The present invention relates to technical field of biological material, particularly to a kind of syringe jacket high intensity anti-biotic material and preparation thereof Method.
Background technology
The material that the disposable syringe overcoat currently used is conventional is petroleum-based plastics (such as polypropylene), although solve intersection The problem infected, but it is substantially after using and processes by burning, brings serious pollution to environment.At present, a lot of producers are all Doing a lot of effort in terms of the pollution-free degraded of syringe jacket, domestic existing producer is proposed by degradable material systems such as polylactic acid The disposable syringe overcoat made, but its production cost is higher, and the institute present invention have studied several macromolecule material of good performance Material, utilizes its respective advantage to be synthesized a kind of novel compositions to the shortcoming reducing single macromolecular material.It addition, one As syringe in factory by ethylene oxide sterilizing, but have small part antibacterial for being killed, in the time later again Meeting amount reproduction, patient is likely to infected after having used this syringe.The most reasonably obtain one the most antibacterial but also can drop The syringe jacket material solved has become the study hotspot of modern medical material.Have excellent so nowadays developing one The syringe jacket material of characteristic is just particularly important.
Summary of the invention
For solving above-mentioned technical problem, the present invention provides a kind of syringe jacket high intensity anti-biotic material and preparation method thereof, By using specified raw material to be combined, coordinate corresponding production technology, the syringe jacket high intensity anti-biotic material obtained, Its stable performance, intensity height, have antibacterial functions, it is possible to meet the requirement of industry, have preferable application prospect.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of syringe jacket high intensity anti-biotic material, is prepared by the raw materials in: polymethyl methacrylate 15- 25 parts, polyether-tribasic alcohol 10-15 part, polyglycolic acid 5-10 part, polyether sulfone 3-7 part, glass fibre 3-8 part, acetate fiber 5-12 Part, trisodium citrate 5-8 part, sulfadiazine 3-5 part, ethambutol 5-8 part, glycine betaine 3-6 part, "Antifungin". 2-6 part, phenyl second Propylmalonic acid diethylester 2-4 part, firming agent 4-7 part, stabilizer 3-8 part, catalyst 1-3 part.
Preferably, during described firming agent is selected from DADPS, diethylenetriamine, 2-methylimidazole, sorbitol Plant or several.
Preferably, described stabilizer is selected from Phenyl Di-2-ethyl Hexyl Phosphite, epoxy soybean oil, aluminium stearate, the double tristearin of ethylene One or more in amide.
Preferably, described catalyst is selected from dibutyl tin laurate, stannous octoate, tributyl 2-acetylcitrate, inclined benzene One or more in tricarboxylic acid three monooctyl ester.
The preparation method of described syringe jacket high intensity anti-biotic material, comprises the following steps:
(1) each raw material is weighed according to weight portion；
(2) polymethyl methacrylate, polyether-tribasic alcohol, polyglycolic acid, polyether sulfone, glass fibre, acetate fiber are added anti- Answering in still, pressurization, pyroreaction, pressure is 4-5MPa, and reaction temperature is 500-560 DEG C, in 45 minutes response time, then lowers the temperature To 320 DEG C, add glycine betaine, stabilizer, be incubated 10-20 minute after stirring, obtain pyroreaction thing；
(3) trisodium citrate, sulfadiazine, ethambutol, "Antifungin"., ethyl benzoic acid are added stirred tank, Being filled with nitrogen, reaction in furnace temperature is 320-360 DEG C, reacts 20-40 minute, obtains stirring mixture；
(4) the pyroreaction thing of step (2) and the stirring mixture of step (3) are implanted sequentially banburying stove, mixing speed 250- 350 revs/min, reaction temperature is 370-400 DEG C, then sequentially adds firming agent, catalyst, 30-40 minute response time, Naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor being injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor step (5) cooled down is injected in double screw extruder, and extruding pelletization, screw speed is 1000- 1200 revs/min, extruder temperature is 220-260 DEG C, obtains material granule；
(7) material granule in step (6) being added injection machine and make finished product, reaction temperature controls as 245-260 DEG C, injection Time is the 2-3 second, and the dwell time is 0.3 second, and screw speed is 220-260 rev/min, and injection pressure is 85MPa.
Compared with prior art, it has the beneficial effect that the present invention
(1) syringe jacket of the present invention with high intensity anti-biotic material with polymethyl methacrylate, polyether-tribasic alcohol, PVOH Acid, polyether sulfone, glass fibre, acetate fiber are main component, by adding glycine betaine, trisodium citrate, sulfadiazine, ethamine Butanol, "Antifungin"., ethyl benzoic acid, stabilizer, firming agent, catalyst, be aided with high-temperature stirring, compressive reaction, The techniques such as catalytic reaction, extrusion, pressing mold are moulding so that the syringe jacket high intensity anti-biotic material being prepared from, its performance Stable, intensity height, has antibacterial functions, it is possible to meet the requirement of industry, has preferable application prospect.
(2) the syringe jacket high intensity anti-biotic material raw material of the present invention is cheap, technique simple, is suitable to large-scale industry Change and use, practical.
Detailed description of the invention
Below in conjunction with specific embodiment, the technical scheme of invention is described in detail.
Embodiment 1
(1) polymethyl methacrylate 15 parts, polyether-tribasic alcohol 10 parts, polyglycolic acid 5 parts, polyether sulfone 3 are weighed according to weight portion Part, glass fibre 3 parts, acetate fiber 5 parts, trisodium citrate 5 parts, sulfadiazine 3 parts, ethambutol 5 parts, glycine betaine 3 parts, boron Acid 2 parts of magnesium, ethyl benzoic acid 2 parts, DADPS 4 parts, Phenyl Di-2-ethyl Hexyl Phosphite 3 parts, tin dilaurate Dibutyl tin 1 part；
(2) polymethyl methacrylate, polyether-tribasic alcohol, polyglycolic acid, polyether sulfone, glass fibre, acetate fiber are added anti- Answering in still, pressurization, pyroreaction, pressure is 4MPa, and reaction temperature is 500 DEG C, in 45 minutes response time, is then cooled to 320 DEG C, add glycine betaine, Phenyl Di-2-ethyl Hexyl Phosphite, be incubated 10 minutes after stirring, obtain pyroreaction thing；
(3) trisodium citrate, sulfadiazine, ethambutol, "Antifungin"., ethyl benzoic acid are added stirred tank, Being filled with nitrogen, reaction in furnace temperature is 320 DEG C, reacts 20 minutes, obtains stirring mixture；
(4) the pyroreaction thing of step (2) and the stirring mixture of step (3) are implanted sequentially banburying stove, mixing speed 250 Rev/min, reaction temperature is 370 DEG C, then sequentially adds DADPS, dibutyl tin laurate, response time 30 minutes, naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor being injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor that step (5) cooled down is injected in double screw extruder, extruding pelletization, and screw speed is 1000 turns/ Minute, extruder temperature is 220 DEG C, obtains material granule；
(7) material granule in step (6) being added injection machine and make finished product, it is 245 DEG C that reaction temperature controls, injection time Being 2 seconds, the dwell time is 0.3 second, and screw speed is 220 revs/min, and injection pressure is 85MPa.
The syringe jacket high intensity anti-biotic material test result prepared is as shown in table 1.
Embodiment 2
(1) polymethyl methacrylate 18 parts, polyether-tribasic alcohol 12 parts, polyglycolic acid 7 parts, polyether sulfone 4 are weighed according to weight portion Part, glass fibre 5 parts, acetate fiber 7 parts, trisodium citrate 6 parts, sulfadiazine 4 parts, ethambutol 6 parts, glycine betaine 4 parts, boron Acid 3 parts of magnesium, ethyl benzoic acid 2 parts, diethylenetriamine 5 parts, epoxy soybean oil 4 parts, stannous octoate 2 parts；
(2) polymethyl methacrylate, polyether-tribasic alcohol, polyglycolic acid, polyether sulfone, glass fibre, acetate fiber are added anti- Answering in still, pressurization, pyroreaction, pressure is 4.4MPa, and reaction temperature is 520 DEG C, in 45 minutes response time, is then cooled to 320 DEG C, add glycine betaine, epoxy soybean oil, be incubated 13 minutes after stirring, obtain pyroreaction thing；
(3) trisodium citrate, sulfadiazine, ethambutol, "Antifungin"., ethyl benzoic acid are added stirred tank, Being filled with nitrogen, reaction in furnace temperature is 330 DEG C, reacts 25 minutes, obtains stirring mixture；
(4) the pyroreaction thing of step (2) and the stirring mixture of step (3) are implanted sequentially banburying stove, mixing speed 280 Rev/min, reaction temperature is 380 DEG C, then sequentially adds diethylenetriamine, stannous octoate, 33 minutes response time, natural It is cooled to 125 DEG C, obtains material precursor；
(5) material precursor being injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor that step (5) cooled down is injected in double screw extruder, extruding pelletization, and screw speed is 1050 turns/ Minute, extruder temperature is 230 DEG C, obtains material granule；
(7) material granule in step (6) being added injection machine and make finished product, it is 250 DEG C that reaction temperature controls, injection time Being 2 seconds, the dwell time is 0.3 second, and screw speed is 230 revs/min, and injection pressure is 85MPa.
The syringe jacket high intensity anti-biotic material test result prepared is as shown in table 1.
Embodiment 3
(1) polymethyl methacrylate 22 parts, polyether-tribasic alcohol 14 parts, polyglycolic acid 9 parts, polyether sulfone 6 are weighed according to weight portion Part, glass fibre 7 parts, acetate fiber 10 parts, trisodium citrate 7 parts, sulfadiazine 4 parts, ethambutol 7 parts, glycine betaine 5 parts, "Antifungin". 5 parts, ethyl benzoic acid 3 parts, 2-methylimidazole 6 parts, aluminium stearate 7 parts, tributyl 2-acetylcitrate 2 Part；
(2) polymethyl methacrylate, polyether-tribasic alcohol, polyglycolic acid, polyether sulfone, glass fibre, acetate fiber are added anti- Answering in still, pressurization, pyroreaction, pressure is 4.8MPa, and reaction temperature is 540 DEG C, in 45 minutes response time, is then cooled to 320 DEG C, add glycine betaine, aluminium stearate, be incubated 18 minutes after stirring, obtain pyroreaction thing；
(3) trisodium citrate, sulfadiazine, ethambutol, "Antifungin"., ethyl benzoic acid are added stirred tank, Being filled with nitrogen, reaction in furnace temperature is 350 DEG C, reacts 35 minutes, obtains stirring mixture；
(4) the pyroreaction thing of step (2) and the stirring mixture of step (3) are implanted sequentially banburying stove, mixing speed 300 Rev/min, reaction temperature is 390 DEG C, then sequentially adds 2-methylimidazole, tributyl 2-acetylcitrate, response time 38 Minute, naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor being injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor that step (5) cooled down is injected in double screw extruder, extruding pelletization, and screw speed is 1100 turns/ Minute, extruder temperature is 250 DEG C, obtains material granule；
(7) material granule in step (6) being added injection machine and make finished product, it is 255 DEG C that reaction temperature controls, injection time Being 3 seconds, the dwell time is 0.3 second, and screw speed is 250 revs/min, and injection pressure is 85MPa.
The syringe jacket high intensity anti-biotic material test result prepared is as shown in table 1.
Embodiment 4
(1) polymethyl methacrylate 25 parts, polyether-tribasic alcohol 15 parts, polyglycolic acid 10 parts, polyether sulfone 7 are weighed according to weight portion Part, glass fibre 8 parts, acetate fiber 12 parts, trisodium citrate 8 parts, sulfadiazine 5 parts, ethambutol 8 parts, glycine betaine 6 parts, "Antifungin". 6 parts, ethyl benzoic acid 4 parts, sorbitol 7 parts, ethylene bis stearamide 8 parts, trimellitic acid three are pungent Ester 3 parts；
(2) polymethyl methacrylate, polyether-tribasic alcohol, polyglycolic acid, polyether sulfone, glass fibre, acetate fiber are added anti- Answering in still, pressurization, pyroreaction, pressure is 5MPa, and reaction temperature is 560 DEG C, in 45 minutes response time, is then cooled to 320 DEG C, add glycine betaine, ethylene bis stearamide, be incubated 20 minutes after stirring, obtain pyroreaction thing；
(3) trisodium citrate, sulfadiazine, ethambutol, "Antifungin"., ethyl benzoic acid are added stirred tank, Being filled with nitrogen, reaction in furnace temperature is 360 DEG C, reacts 40 minutes, obtains stirring mixture；
(4) the pyroreaction thing of step (2) and the stirring mixture of step (3) are implanted sequentially banburying stove, mixing speed 350 Rev/min, reaction temperature is 400 DEG C, then sequentially adds sorbitol, trimellitic acid three monooctyl ester, 40 minutes response time, Naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor being injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor that step (5) cooled down is injected in double screw extruder, extruding pelletization, and screw speed is 1200 turns/ Minute, extruder temperature is 260 DEG C, obtains material granule；
(7) material granule in step (6) being added injection machine and make finished product, it is 260 DEG C that reaction temperature controls, injection time Being 3 seconds, the dwell time is 0.3 second, and screw speed is 260 revs/min, and injection pressure is 85MPa.
The syringe jacket high intensity anti-biotic material test result prepared is as shown in table 1.
Comparative example 1
(1) according to weight portion weigh polymethyl methacrylate 15 parts, polyglycolic acid 5 parts, polyether sulfone 3 parts, glass fibre 3 parts, Acetate fiber 5 parts, trisodium citrate 5 parts, sulfadiazine 3 parts, ethambutol 5 parts, glycine betaine 3 parts, phenylethyl malonic acid two Ethyl ester 2 parts, DADPS 4 parts, Phenyl Di-2-ethyl Hexyl Phosphite 3 parts, dibutyl tin laurate 1 part；
(2) polymethyl methacrylate, polyglycolic acid, polyether sulfone, glass fibre, acetate fiber are added in reactor, pressurization, Pyroreaction, pressure is 4MPa, and reaction temperature is 500 DEG C, in 45 minutes response time, is then cooled to 320 DEG C, adds Radix Betae Alkali, Phenyl Di-2-ethyl Hexyl Phosphite, be incubated 10 minutes after stirring, obtain pyroreaction thing；
(3) trisodium citrate, sulfadiazine, ethambutol, ethyl benzoic acid are added stirred tank, be filled with nitrogen Gas, reaction in furnace temperature is 320 DEG C, reacts 20 minutes, obtains stirring mixture；
(4) the pyroreaction thing of step (2) and the stirring mixture of step (3) are implanted sequentially banburying stove, mixing speed 250 Rev/min, reaction temperature is 370 DEG C, then sequentially adds DADPS, dibutyl tin laurate, response time 30 minutes, naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor being injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor that step (5) cooled down is injected in double screw extruder, extruding pelletization, and screw speed is 1000 turns/ Minute, extruder temperature is 220 DEG C, obtains material granule；
(7) material granule in step (6) being added injection machine and make finished product, it is 245 DEG C that reaction temperature controls, injection time Being 2 seconds, the dwell time is 0.3 second, and screw speed is 220 revs/min, and injection pressure is 85MPa.
The syringe jacket high intensity anti-biotic material test result prepared is as shown in table 1.
Comparative example 2
(1) polymethyl methacrylate 25 parts, polyether-tribasic alcohol 15 parts, polyglycolic acid 10 parts, glass fibers are weighed according to weight portion Tie up 8 parts, acetate fiber 12 parts, trisodium citrate 8 parts, ethambutol 8 parts, glycine betaine 6 parts, "Antifungin". 6 parts, phenylethyl the third two Diethyl phthalate 4 parts, sorbitol 7 parts, ethylene bis stearamide 8 parts, trimellitic acid three monooctyl ester 3 parts；
(2) polymethyl methacrylate, polyether-tribasic alcohol, polyglycolic acid, glass fibre, acetate fiber are added in reactor, Pressurization, pyroreaction, pressure is 5MPa, and reaction temperature is 560 DEG C, in 45 minutes response time, is then cooled to 320 DEG C, adds Glycine betaine, ethylene bis stearamide, be incubated 20 minutes after stirring, obtain pyroreaction thing；
(3) trisodium citrate, ethambutol, "Antifungin"., ethyl benzoic acid are added stirred tank, are filled with nitrogen, Reaction in furnace temperature is 360 DEG C, reacts 40 minutes, obtains stirring mixture；
(4) the pyroreaction thing of step (2) and the stirring mixture of step (3) are implanted sequentially banburying stove, mixing speed 350 Rev/min, reaction temperature is 400 DEG C, then sequentially adds sorbitol, trimellitic acid three monooctyl ester, 40 minutes response time, Naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor being injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor that step (5) cooled down is injected in double screw extruder, extruding pelletization, and screw speed is 1200 turns/ Minute, extruder temperature is 260 DEG C, obtains material granule；
(7) material granule in step (6) being added injection machine and make finished product, it is 260 DEG C that reaction temperature controls, injection time Being 3 seconds, the dwell time is 0.3 second, and screw speed is 260 revs/min, and injection pressure is 85MPa.
The syringe jacket high intensity anti-biotic material test result prepared is as shown in table 1.
The syringe jacket high intensity anti-biotic material prepared of embodiment 1-4 and comparative example 1-2 is ruptured respectively Percentage elongation, shore hardness, Acute systemic toxicity, these several performance tests of sterility test.
Table 1
　 Elongation at break (%) Shore hardness (D) Acute systemic toxicity Sterility test
Embodiment 1 347 101 React without Acute systemic toxicity 99.99%
Embodiment 2 354 99 React without Acute systemic toxicity 99.99%
Embodiment 3 358 100 React without Acute systemic toxicity 99.99%
Embodiment 4 353 102 React without Acute systemic toxicity 99.99%
Comparative example 1 179 41 React without Acute systemic toxicity 99.99%
Comparative example 2 164 46 React without Acute systemic toxicity 99.99%
The syringe jacket of the present invention with high intensity anti-biotic material with polymethyl methacrylate, polyether-tribasic alcohol, polyglycolic acid, Polyether sulfone, glass fibre, acetate fiber are main component, by adding glycine betaine, trisodium citrate, sulfadiazine, ethamine fourth Alcohol, "Antifungin"., ethyl benzoic acid, stabilizer, firming agent, catalyst, be aided with high-temperature stirring, compressive reaction, urge Change techniques such as reacting, extrusion, pressing mold are moulding so that the syringe jacket high intensity anti-biotic material being prepared from, its performance is steady Fixed, intensity height, has antibacterial functions, it is possible to meet the requirement of industry, has preferable application prospect.Outside the syringe of the present invention Apply mechanically that high intensity anti-biotic material raw material is cheap, technique simple, be suitable to heavy industrialization and use, practical.
The foregoing is only embodiments of the invention, not thereby limit the scope of the claims of the present invention, every utilize this Equivalent structure or equivalence flow process that bright description is made convert, or are directly or indirectly used in other relevant technology necks Territory, is the most in like manner included in the scope of patent protection of the present invention.

Claims (5)

1. a syringe jacket high intensity anti-biotic material, it is characterised in that: it is prepared by the raw materials in: poly-methyl Acrylic acid methyl ester. 15-25 part, polyether-tribasic alcohol 10-15 part, polyglycolic acid 5-10 part, polyether sulfone 3-7 part, glass fibre 3-8 part, Acetate fiber 5-12 part, trisodium citrate 5-8 part, sulfadiazine 3-5 part, ethambutol 5-8 part, glycine betaine 3-6 part, "Antifungin". 2-6 part, ethyl benzoic acid 2-4 part, firming agent 4-7 part, stabilizer 3-8 part, catalyst 1-3 part.
Syringe jacket high intensity anti-biotic material the most according to claim 1, it is characterised in that: described firming agent is selected from One or more in DADPS, diethylenetriamine, 2-methylimidazole, sorbitol.
Syringe jacket high intensity anti-biotic material the most according to claim 1, it is characterised in that: described stabilizer is selected from One or more in Phenyl Di-2-ethyl Hexyl Phosphite, epoxy soybean oil, aluminium stearate, ethylene bis stearamide.
Syringe jacket high intensity anti-biotic material the most according to claim 1, it is characterised in that: described catalyst is selected from One or more in dibutyl tin laurate, stannous octoate, tributyl 2-acetylcitrate, trimellitic acid three monooctyl ester.
5., according to the preparation method of the arbitrary described syringe jacket high intensity anti-biotic material of Claims 1 to 4, its feature exists In, comprise the following steps:
(1) each raw material is weighed according to weight portion；
(2) polymethyl methacrylate, polyether-tribasic alcohol, polyglycolic acid, polyether sulfone, glass fibre, acetate fiber are added anti- Answering in still, pressurization, pyroreaction, pressure is 4-5MPa, and reaction temperature is 500-560 DEG C, in 45 minutes response time, then lowers the temperature To 320 DEG C, add glycine betaine, stabilizer, be incubated 10-20 minute after stirring, obtain pyroreaction thing；
(3) trisodium citrate, sulfadiazine, ethambutol, "Antifungin"., ethyl benzoic acid are added stirred tank, Being filled with nitrogen, reaction in furnace temperature is 320-360 DEG C, reacts 20-40 minute, obtains stirring mixture；
(4) the pyroreaction thing of step (2) and the stirring mixture of step (3) are implanted sequentially banburying stove, mixing speed 250- 350 revs/min, reaction temperature is 370-400 DEG C, then sequentially adds firming agent, catalyst, 30-40 minute response time, Naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor being injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor step (5) cooled down is injected in double screw extruder, and extruding pelletization, screw speed is 1000- 1200 revs/min, extruder temperature is 220-260 DEG C, obtains material granule；
(7) material granule in step (6) being added injection machine and make finished product, reaction temperature controls as 245-260 DEG C, injection Time is the 2-3 second, and the dwell time is 0.3 second, and screw speed is 220-260 rev/min, and injection pressure is 85MPa.
CN201610760861.9A 2016-08-30 2016-08-30 A kind of syringe jacket high intensity anti-biotic material and preparation method thereof Pending CN106280174A (en)

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