CN106366524A - Medicinal polyvinyl alcohol material and preparation method thereof - Google Patents

Medicinal polyvinyl alcohol material and preparation method thereof Download PDF

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Publication number
CN106366524A
CN106366524A CN201610761708.8A CN201610761708A CN106366524A CN 106366524 A CN106366524 A CN 106366524A CN 201610761708 A CN201610761708 A CN 201610761708A CN 106366524 A CN106366524 A CN 106366524A
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parts
acid
polyvinyl alcohol
temperature
medical pva
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胡何辉
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/02—Making granules by dividing preformed material
    • B29B9/06—Making granules by dividing preformed material in the form of filamentary material, e.g. combined with extrusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/76—Measuring, controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/76—Measuring, controlling or regulating
    • B29C45/77—Measuring, controlling or regulating of velocity or pressure of moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/92—Measuring, controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2945/00—Indexing scheme relating to injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould
    • B29C2945/76—Measuring, controlling or regulating
    • B29C2945/76494—Controlled parameter
    • B29C2945/76498—Pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2945/00—Indexing scheme relating to injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould
    • B29C2945/76—Measuring, controlling or regulating
    • B29C2945/76494—Controlled parameter
    • B29C2945/76531—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2945/00—Indexing scheme relating to injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould
    • B29C2945/76—Measuring, controlling or regulating
    • B29C2945/76494—Controlled parameter
    • B29C2945/76595—Velocity
    • B29C2945/76605—Velocity rotational movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2945/00—Indexing scheme relating to injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould
    • B29C2945/76—Measuring, controlling or regulating
    • B29C2945/76655—Location of control
    • B29C2945/76658—Injection unit
    • B29C2945/76665—Injection unit screw
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2948/00—Indexing scheme relating to extrusion moulding
    • B29C2948/92—Measuring, controlling or regulating
    • B29C2948/92504—Controlled parameter
    • B29C2948/9258—Velocity
    • B29C2948/9259—Angular velocity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2948/00—Indexing scheme relating to extrusion moulding
    • B29C2948/92—Measuring, controlling or regulating
    • B29C2948/92504—Controlled parameter
    • B29C2948/92704—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2948/00—Indexing scheme relating to extrusion moulding
    • B29C2948/92—Measuring, controlling or regulating
    • B29C2948/92819—Location or phase of control
    • B29C2948/92857—Extrusion unit
    • B29C2948/92876—Feeding, melting, plasticising or pumping zones, e.g. the melt itself
    • B29C2948/92885—Screw or gear
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
    • C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend

Abstract

The invention discloses a medical polyvinyl alcohol material. The material is prepared from, by weight, 25-45 parts of polyvinyl alcohol, 15-25 parts of polytetrafluoroethylene, 5-10 parts of polyglycolic acido, 8-12 parts of calcium lignosulphonate, 5-10 parts of polypropylene, 6-10 parts of glass fiber, 5-9 parts of polylactic acid, 5-8 parts of ethylenediaminetetraacetic acid, 3-6 parts of glycine betaine, 3-7 parts of calcium carbonate, 2-4 parts of chlorobutanol, 1-3 parts of sulfadimidine, 2-5 parts of sodium naphthalene acetate, 4-7 parts of curing agent and 3-8 parts of stabilizer. The material has the advantages of stable property, zero toxicity and zero pollutant, high biosafety. At the same time the present invention further discloses a preparation method for the medical polyvinyl alcohol material.

Description

A kind of medical PVA material and preparation method thereof
Technical field
The present invention relates to technical field of biological material, particularly to a kind of medical PVA material and preparation method thereof.
Background technology
Polyvinyl alcohol (abbreviation pva) outward appearance is white powder, is a kind of quite extensive high molecular weight water soluble polymer of purposes, property Can be divided into fiber and the big purposes of non-fiber two between plastics and rubber.Due to pva have uniqueness strong adherence, Epithelium pliability, flatness, oil resistivity, solvent resistance, protecting colloid, gas barrier performance, wearability and specially treated The resistance to water having, therefore in addition to making fibrous raw material, is also largely used to produce coating, binding agent, paper product processing agent, emulsifying The products such as agent, dispersant, thin film, range of application throughout weaving, food, medicine, building, timber processing, papermaking, printing, agricultural, The industries such as iron and steel, macromolecule chemical industry.Polyvinyl alcohol resin series of products system white solid, external form divides cotton-shaped, graininess, powdery three Kind；Nonpoisonous and tasteless, pollution-free, can dissolve in 80--90 DEG C of water.Its aqueous solution has good cementability and film property；Can oil resistant Most of organic solvent such as class, lubricant and hydro carbons；There is long-chain polyhydric alcohol esterification, the chemical property such as etherificate, acetalation.It is based on The excellent physico-chemical property of polyvinyl alcohol material, we are applied to field of medical materials, especially in terms of medical catheter Application is so as to extensively use the feature of its nontoxic pollution-free, biological safety.So nowadays developing a kind of performance Excellent medical PVA material is particularly important.
Content of the invention
For solving above-mentioned technical problem, the present invention provides a kind of medical PVA material and preparation method thereof, by using special Determine raw material to be combined, coordinate corresponding production technology, the medical PVA material obtaining, its stable performance, nontoxic no dirt Contaminate, there is higher biological safety, disclosure satisfy that the requirement of industry, there is preferable application prospect.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of medical PVA material, is prepared by the raw materials in: polyvinyl alcohol 25-45 part, politef 15- 25 parts, polyglycolic acid 5-10 part, calcium lignosulfonate 8-12 part, polypropylene 5-10 part, glass fibre 6-10 part, polylactic acid 5-9 Part, ethylenediaminetetraacetic acid 5-8 part, glycine betaine 3-6 part, Calcium Carbonate 3-7 part, chlorobutanol 2-4 part, sulfadimidine 1-3 Part, naphthalene Sodium Acetate Trihydrate 2-5 part, firming agent 4-7 part, stabilizer 3-8 part, catalyst 1-3 part.
Preferably, described firming agent be selected from DADPS, diethylenetriamine, 2-methylimidazole, in Sorbitol one Plant or several.
Preferably, described stabilizer is selected from Phenyl Di-2-ethyl Hexyl Phosphite, epoxy soybean oil, aluminium stearate, the double Hard Fat of ethylene One or more of amide.
Preferably, described catalyst is selected from dibutyl tin laurate, stannous octoate, tributyl 2-acetylcitrate, inclined benzene One or more of tricarboxylic acid three monooctyl ester.
The preparation method of described medical PVA material, comprises the following steps:
(1) weigh each raw material according to weight portion；
(2) polyvinyl alcohol, politef, polyglycolic acid, polypropylene, glass fibre, polylactic acid are added in reactor, plus Pressure, pyroreaction, pressure is 3-4mpa, and reaction temperature is 450-620 DEG C, in 70 minutes response time, is then cooled to 360 DEG C, Add glycine betaine, stabilizer, be incubated 15-20 minute after stirring, obtain pyroreaction thing；
(3) calcium lignosulfonate, ethylenediaminetetraacetic acid, Calcium Carbonate, chlorobutanol, sulfadimidine, naphthalene Sodium Acetate Trihydrate are added Enter stirred tank, be filled with nitrogen, reaction in furnace temperature is 320-360 DEG C, react 20-40 minute, obtain stirring mixture；
(4) stirring mixture of the pyroreaction thing of step (2) and step (3) is implanted sequentially banburying stove, mixing speed 300- 500 revs/min, reaction temperature is 380-420 DEG C, then sequentially adds firming agent, catalyst, response time 30-40 minute, Naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor is injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor that step (5) cools down is injected in double screw extruder, extruding pelletization, screw speed is 1200- 1500 revs/min, extruder temperature is 220-260 DEG C, obtains material granule；
(7) material granule in step (6) is added injection machine to make finished product, reaction temperature is controlled to 245-260 DEG C, injection Time is the 2-3 second, and the dwell time is 0.3 second, and screw speed is 220-260 rev/min, and injection pressure is 85mpa.
Compared with prior art, its advantage is the present invention:
(1) the medical PVA material of the present invention is with polyvinyl alcohol, politef, polyglycolic acid, polypropylene, glass fibers Dimension, polylactic acid are main component, by adding glycine betaine, calcium lignosulfonate, ethylenediaminetetraacetic acid, Calcium Carbonate, the tertiary fourth of trichlorine Alcohol, sulfadimidine, naphthalene Sodium Acetate Trihydrate, stabilizer, firming agent, catalyst, be aided with high-temperature stirring, compressive reaction, catalytic reaction, Extrusion, the technique such as pressing mold is moulding so that the medical PVA material that is prepared from, its stable performance, nontoxic pollution-free, have Higher biological safety, disclosure satisfy that the requirement of industry, has preferable application prospect.
(2) the medical PVA material feedstock of the present invention is cheap, process is simple, is suitable to heavy industrialization and uses, real Strong with property.
Specific embodiment
With reference to specific embodiment, the technical scheme of invention is described in detail.
Embodiment 1
(1) according to weight portion weigh 25 parts of polyvinyl alcohol, 15 parts of politef, 5 parts of polyglycolic acid, 8 parts of calcium lignosulfonate, 5 parts of polypropylene, 6 parts of glass fibre, 5 parts of polylactic acid, 5 parts of ethylenediaminetetraacetic acid, 3 parts of glycine betaine, 3 parts of Calcium Carbonate, the tertiary fourth of trichlorine 2 parts of alcohol, 1 part of sulfadimidine, 2 parts of naphthalene Sodium Acetate Trihydrate, 4 parts of DADPS, 3 parts of Phenyl Di-2-ethyl Hexyl Phosphite, two Laurels 1 part of sour dibutyl tin；
(2) polyvinyl alcohol, politef, polyglycolic acid, polypropylene, glass fibre, polylactic acid are added in reactor, plus Pressure, pyroreaction, pressure is 3mpa, and reaction temperature is 450 DEG C, in 70 minutes response time, is then cooled to 360 DEG C, adds sweet Dish alkali, Phenyl Di-2-ethyl Hexyl Phosphite, are incubated 15 minutes after stirring, obtain pyroreaction thing；
(3) calcium lignosulfonate, ethylenediaminetetraacetic acid, Calcium Carbonate, chlorobutanol, sulfadimidine, naphthalene Sodium Acetate Trihydrate are added Enter stirred tank, be filled with nitrogen, reaction in furnace temperature is 320 DEG C, react 20 minutes, obtain stirring mixture；
(4) stirring mixture of the pyroreaction thing of step (2) and step (3) is implanted sequentially banburying stove, mixing speed 300 Rev/min, reaction temperature is 380 DEG C, then sequentially adds DADPS, dibutyl tin laurate, response time 30 minutes, naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor is injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor cooling down step (5) is injected in double screw extruder, extruding pelletization, and screw speed is 1200 turns/ Minute, extruder temperature is 220 DEG C, obtains material granule；
(7) material granule in step (6) is added injection machine to make finished product, reaction temperature is controlled to 245 DEG C, injection time For 2 seconds, the dwell time was 0.3 second, and screw speed is 220 revs/min, and injection pressure is 85mpa.
Prepared medical PVA testing of materials result is as shown in table 1.
Embodiment 2
(1) 30 parts of polyvinyl alcohol, 18 parts of politef, 7 parts of polyglycolic acid, calcium lignosulfonate 10 are weighed according to weight portion Part, 7 parts of polypropylene, 8 parts of glass fibre, 6 parts of polylactic acid, 6 parts of ethylenediaminetetraacetic acid, 4 parts of glycine betaine, 4 parts of Calcium Carbonate, trichlorine uncle 3 parts of butanol, 2 parts of sulfadimidine, 3 parts of naphthalene Sodium Acetate Trihydrate, 5 parts of diethylenetriamine, 4 parts of epoxy soybean oil, 2 parts of stannous octoate；
(2) polyvinyl alcohol, politef, polyglycolic acid, polypropylene, glass fibre, polylactic acid are added in reactor, plus Pressure, pyroreaction, pressure is 3.3mpa, and reaction temperature is 500 DEG C, in 70 minutes response time, is then cooled to 360 DEG C, adds Glycine betaine, epoxy soybean oil, are incubated 17 minutes after stirring, obtain pyroreaction thing；
(3) calcium lignosulfonate, ethylenediaminetetraacetic acid, Calcium Carbonate, chlorobutanol, sulfadimidine, naphthalene Sodium Acetate Trihydrate are added Enter stirred tank, be filled with nitrogen, reaction in furnace temperature is 340 DEG C, react 25 minutes, obtain stirring mixture；
(4) stirring mixture of the pyroreaction thing of step (2) and step (3) is implanted sequentially banburying stove, mixing speed 350 Rev/min, reaction temperature is 390 DEG C, then sequentially adds diethylenetriamine, stannous octoate, 34 minutes response time, natural It is cooled to 125 DEG C, obtain material precursor；
(5) material precursor is injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor cooling down step (5) is injected in double screw extruder, extruding pelletization, and screw speed is 1300 turns/ Minute, extruder temperature is 230 DEG C, obtains material granule；
(7) material granule in step (6) is added injection machine to make finished product, reaction temperature is controlled to 250 DEG C, injection time For 2 seconds, the dwell time was 0.3 second, and screw speed is 230 revs/min, and injection pressure is 85mpa.
Prepared medical PVA testing of materials result is as shown in table 1.
Embodiment 3
(1) 40 parts of polyvinyl alcohol, 23 parts of politef, 9 parts of polyglycolic acid, calcium lignosulfonate 11 are weighed according to weight portion Part, 9 parts of polypropylene, 9 parts of glass fibre, 8 parts of polylactic acid, 7 parts of ethylenediaminetetraacetic acid, 5 parts of glycine betaine, 6 parts of Calcium Carbonate, trichlorine uncle 3 parts of butanol, 2 parts of sulfadimidine, 4 parts of naphthalene Sodium Acetate Trihydrate, 6 parts of 2-methylimidazole, 7 parts of aluminium stearate, acetyl tributyl citrate three fourth 2 parts of ester；
(2) polyvinyl alcohol, politef, polyglycolic acid, polypropylene, glass fibre, polylactic acid are added in reactor, plus Pressure, pyroreaction, pressure is 3.8mpa, and reaction temperature is 600 DEG C, in 70 minutes response time, is then cooled to 360 DEG C, adds Glycine betaine, aluminium stearate, are incubated 19 minutes after stirring, obtain pyroreaction thing；
(3) calcium lignosulfonate, ethylenediaminetetraacetic acid, Calcium Carbonate, chlorobutanol, sulfadimidine, naphthalene Sodium Acetate Trihydrate are added Enter stirred tank, be filled with nitrogen, reaction in furnace temperature is 350 DEG C, react 35 minutes, obtain stirring mixture；
(4) stirring mixture of the pyroreaction thing of step (2) and step (3) is implanted sequentially banburying stove, mixing speed 400 Rev/min, reaction temperature is 400 DEG C, then sequentially adds 2-methylimidazole, catalyst, 38 minutes response time, naturally cold But to 125 DEG C, obtain material precursor；
(5) material precursor is injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor cooling down step (5) is injected in double screw extruder, extruding pelletization, and screw speed is 1400 turns/ Minute, extruder temperature is 240 DEG C, obtains material granule；
(7) material granule in step (6) is added injection machine to make finished product, reaction temperature is controlled to 255 DEG C, injection time For 3 seconds, the dwell time was 0.3 second, and screw speed is 250 revs/min, and injection pressure is 85mpa.
Prepared medical PVA testing of materials result is as shown in table 1.
Embodiment 4
(1) 45 parts of polyvinyl alcohol, 25 parts of politef, 10 parts of polyglycolic acid, calcium lignosulfonate 12 are weighed according to weight portion Part, 10 parts of polypropylene, 10 parts of glass fibre, 9 parts of polylactic acid, 8 parts of ethylenediaminetetraacetic acid, 6 parts of glycine betaine, 7 parts of Calcium Carbonate, trichlorine 4 parts of the tert-butyl alcohol, 3 parts of sulfadimidine, 5 parts of naphthalene Sodium Acetate Trihydrate, 7 parts of Sorbitol, 8 parts of ethylene bis stearamide, trimellitic acid Three 3 parts of monooctyl esters；
(2) polyvinyl alcohol, politef, polyglycolic acid, polypropylene, glass fibre, polylactic acid are added in reactor, plus Pressure, pyroreaction, pressure is 4mpa, and reaction temperature is 620 DEG C, in 70 minutes response time, is then cooled to 360 DEG C, adds sweet Dish alkali, ethylene bis stearamide, are incubated 20 minutes after stirring, obtain pyroreaction thing；
(3) calcium lignosulfonate, ethylenediaminetetraacetic acid, Calcium Carbonate, chlorobutanol, sulfadimidine, naphthalene Sodium Acetate Trihydrate are added Enter stirred tank, be filled with nitrogen, reaction in furnace temperature is 360 DEG C, react 40 minutes, obtain stirring mixture；
(4) stirring mixture of the pyroreaction thing of step (2) and step (3) is implanted sequentially banburying stove, mixing speed 500 Rev/min, reaction temperature is 420 DEG C, then sequentially adds Sorbitol, trimellitic acid three monooctyl ester, 40 minutes response time, Naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor is injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor cooling down step (5) is injected in double screw extruder, extruding pelletization, and screw speed is 1500 turns/ Minute, extruder temperature is 260 DEG C, obtains material granule；
(7) material granule in step (6) is added injection machine to make finished product, reaction temperature is controlled to 260 DEG C, injection time For 3 seconds, the dwell time was 0.3 second, and screw speed is 260 revs/min, and injection pressure is 85mpa.
Prepared medical PVA testing of materials result is as shown in table 1.
Comparative example 1
(1) according to weight portion weigh 25 parts of polyvinyl alcohol, 15 parts of politef, 5 parts of polyglycolic acid, 8 parts of calcium lignosulfonate, 6 parts of glass fibre, 5 parts of polylactic acid, 5 parts of ethylenediaminetetraacetic acid, 3 parts of glycine betaine, 2 parts of chlorobutanol, sulfadimidine 1 Part, 2 parts of naphthalene Sodium Acetate Trihydrate, 4 parts of DADPS, 3 parts of Phenyl Di-2-ethyl Hexyl Phosphite, 1 part of dibutyl tin laurate；
(2) polyvinyl alcohol, politef, polyglycolic acid, glass fibre, polylactic acid are added in reactor, pressurization, high temperature is anti- Should, pressure is 3mpa, and reaction temperature is 450 DEG C, in 70 minutes response time, is then cooled to 360 DEG C, adds glycine betaine, phosphorous Acid-benzene di-isooctyl, is incubated 15 minutes after stirring, obtains pyroreaction thing；
(3) calcium lignosulfonate, ethylenediaminetetraacetic acid, chlorobutanol, sulfadimidine, naphthalene Sodium Acetate Trihydrate are added stirring Kettle, is filled with nitrogen, and reaction in furnace temperature is 320 DEG C, reacts 20 minutes, obtains stirring mixture；
(4) stirring mixture of the pyroreaction thing of step (2) and step (3) is implanted sequentially banburying stove, mixing speed 300 Rev/min, reaction temperature is 380 DEG C, then sequentially adds DADPS, dibutyl tin laurate, response time 30 minutes, naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor is injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor cooling down step (5) is injected in double screw extruder, extruding pelletization, and screw speed is 1200 turns/ Minute, extruder temperature is 220 DEG C, obtains material granule；
(7) material granule in step (6) is added injection machine to make finished product, reaction temperature is controlled to 245 DEG C, injection time For 2 seconds, the dwell time was 0.3 second, and screw speed is 220 revs/min, and injection pressure is 85mpa.
Prepared medical PVA testing of materials result is as shown in table 1.
Comparative example 2
(1) 45 parts of polyvinyl alcohol, 25 parts of politef, 10 parts of polyglycolic acid, calcium lignosulfonate 12 are weighed according to weight portion Part, 10 parts of polypropylene, 9 parts of polylactic acid, 8 parts of ethylenediaminetetraacetic acid, 6 parts of glycine betaine, 7 parts of Calcium Carbonate, 3 parts of sulfadimidine, 5 parts of naphthalene Sodium Acetate Trihydrate, 7 parts of Sorbitol, 8 parts of ethylene bis stearamide, 3 parts of trimellitic acid three monooctyl ester；
(2) polyvinyl alcohol, politef, polyglycolic acid, polypropylene, polylactic acid are added in reactor, pressurization, high temperature is anti- Should, pressure is 4mpa, and reaction temperature is 620 DEG C, in 70 minutes response time, is then cooled to 360 DEG C, adds glycine betaine, ethylene Bis-stearamides, are incubated 20 minutes after stirring, obtain pyroreaction thing；
(3) calcium lignosulfonate, ethylenediaminetetraacetic acid, Calcium Carbonate, sulfadimidine, naphthalene Sodium Acetate Trihydrate are added stirred tank, fill Enter nitrogen, reaction in furnace temperature is 360 DEG C, react 40 minutes, obtain stirring mixture；
(4) stirring mixture of the pyroreaction thing of step (2) and step (3) is implanted sequentially banburying stove, mixing speed 500 Rev/min, reaction temperature is 420 DEG C, then sequentially adds Sorbitol, trimellitic acid three monooctyl ester, 40 minutes response time, Naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor is injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor cooling down step (5) is injected in double screw extruder, extruding pelletization, and screw speed is 1500 turns/ Minute, extruder temperature is 260 DEG C, obtains material granule；
(7) material granule in step (6) is added injection machine to make finished product, reaction temperature is controlled to 260 DEG C, injection time For 3 seconds, the dwell time was 0.3 second, and screw speed is 260 revs/min, and injection pressure is 85mpa.
Prepared medical PVA testing of materials result is as shown in table 1.
The prepared medical PVA material of embodiment 1-4 and comparative example 1-2 is carried out elongation at break, bending respectively Modulus, Intradermal irritant reaction, Acute systemic toxicity react this several performance tests.
Table 1
　 Elongation at break (%) Bending moduluses (mpa) Intradermal stimulates Acute systemic toxicity
Embodiment 1 289 865 No Intradermal stimulates No Acute systemic toxicity reaction
Embodiment 2 295 873 No Intradermal stimulates No Acute systemic toxicity reaction
Embodiment 3 298 869 No Intradermal stimulates No Acute systemic toxicity reaction
Embodiment 4 294 871 No Intradermal stimulates No Acute systemic toxicity reaction
Comparative example 1 149 610 No Intradermal stimulates No Acute systemic toxicity reaction
Comparative example 2 137 637 No Intradermal stimulates No Acute systemic toxicity reaction
The medical PVA material of the present invention is with polyvinyl alcohol, politef, polyglycolic acid, polypropylene, glass fibre, poly- Lactic acid is main component, by adding glycine betaine, calcium lignosulfonate, ethylenediaminetetraacetic acid, Calcium Carbonate, chlorobutanol, sulphur Amine diformazan pyrimidine, naphthalene Sodium Acetate Trihydrate, stabilizer, firming agent, catalyst, be aided with high-temperature stirring, compressive reaction, catalytic reaction, extrusion, The technique such as pressing mold is moulding so that the medical PVA material that is prepared from, its stable performance, nontoxic pollution-free, have higher Biological safety, disclosure satisfy that the requirement of industry, there is preferable application prospect.The medical PVA material of the present invention is former Material is cheap, process is simple, is suitable to heavy industrialization and uses, practical.
The foregoing is only embodiments of the invention, not thereby limit the present invention the scope of the claims, every using this Equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks Domain, is included within the scope of the present invention.

Claims (5)

1. a kind of medical PVA material it is characterised in that: be prepared by the raw materials in: polyvinyl alcohol 25-45 part, Politef 15-25 part, polyglycolic acid 5-10 part, calcium lignosulfonate 8-12 part, polypropylene 5-10 part, glass fibre 6-10 Part, polylactic acid 5-9 part, ethylenediaminetetraacetic acid 5-8 part, glycine betaine 3-6 part, Calcium Carbonate 3-7 part, chlorobutanol 2-4 part, sulfanilamide Diformazan pyrimidine 1-3 part, naphthalene Sodium Acetate Trihydrate 2-5 part, firming agent 4-7 part, stabilizer 3-8 part, catalyst 1-3 part.
2. medical PVA material according to claim 1 it is characterised in that: described firming agent be selected from diaminourea hexichol One or more of sulfone, diethylenetriamine, 2-methylimidazole, Sorbitol.
3. medical PVA material according to claim 1 it is characterised in that: described stabilizer be selected from phosphorous acid-benzene One or more of di-isooctyl, epoxy soybean oil, aluminium stearate, ethylene bis stearamide.
4. medical PVA material according to claim 1 it is characterised in that: described catalyst be selected from tin dilaurate two One or more of butyl tin, stannous octoate, tributyl 2-acetylcitrate, trimellitic acid three monooctyl ester.
5. the preparation method according to the arbitrary described medical PVA material of Claims 1 to 4 it is characterised in that include with Lower step:
(1) weigh each raw material according to weight portion；
(2) polyvinyl alcohol, politef, polyglycolic acid, polypropylene, glass fibre, polylactic acid are added in reactor, plus Pressure, pyroreaction, pressure is 3-4mpa, and reaction temperature is 450-620 DEG C, in 70 minutes response time, is then cooled to 360 DEG C, Add glycine betaine, stabilizer, be incubated 15-20 minute after stirring, obtain pyroreaction thing；
(3) calcium lignosulfonate, ethylenediaminetetraacetic acid, Calcium Carbonate, chlorobutanol, sulfadimidine, naphthalene Sodium Acetate Trihydrate are added Enter stirred tank, be filled with nitrogen, reaction in furnace temperature is 320-360 DEG C, react 20-40 minute, obtain stirring mixture；
(4) stirring mixture of the pyroreaction thing of step (2) and step (3) is implanted sequentially banburying stove, mixing speed 300- 500 revs/min, reaction temperature is 380-420 DEG C, then sequentially adds firming agent, catalyst, response time 30-40 minute, Naturally cool to 125 DEG C, obtain material precursor；
(5) material precursor is injected cold pot, slow cooling is until temperature drops to 45 DEG C；
(6) material precursor that step (5) cools down is injected in double screw extruder, extruding pelletization, screw speed is 1200- 1500 revs/min, extruder temperature is 220-260 DEG C, obtains material granule；
(7) material granule in step (6) is added injection machine to make finished product, reaction temperature is controlled to 245-260 DEG C, injection Time is the 2-3 second, and the dwell time is 0.3 second, and screw speed is 220-260 rev/min, and injection pressure is 85mpa.
CN201610761708.8A 2016-08-30 2016-08-30 Medicinal polyvinyl alcohol material and preparation method thereof Pending CN106366524A (en)

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CN107962696A (en) * 2017-12-14 2018-04-27 陈逊 A kind of manufacturing process of polyglycolic acid resin laminated film
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