CN106279404A - 一种可溶且稳定的异质二聚tcr - Google Patents
一种可溶且稳定的异质二聚tcr Download PDFInfo
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- CN106279404A CN106279404A CN201510260322.4A CN201510260322A CN106279404A CN 106279404 A CN106279404 A CN 106279404A CN 201510260322 A CN201510260322 A CN 201510260322A CN 106279404 A CN106279404 A CN 106279404A
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- tcr
- chain
- disulfide bond
- present
- interchain disulfide
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- A—HUMAN NECESSITIES
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Landscapes
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Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510260322.4A CN106279404A (zh) | 2015-05-20 | 2015-05-20 | 一种可溶且稳定的异质二聚tcr |
| PCT/CN2016/077680 WO2016184258A1 (zh) | 2015-05-20 | 2016-03-29 | 一种可溶且稳定的异质二聚tcr |
| JP2018512466A JP6640994B2 (ja) | 2015-05-20 | 2016-03-29 | 安定した可溶性ヘテロ二量体ｔｃｒ |
| EP16795745.5A EP3299389A4 (en) | 2015-05-20 | 2016-03-29 | Soluble and stable heterodimeric tcr |
| CA2986273A CA2986273A1 (en) | 2015-05-20 | 2016-03-29 | Soluble and stable heterodimeric tcr |
| US15/573,692 US10316087B2 (en) | 2015-05-20 | 2016-03-29 | Soluble and stable heterodimeric TCR |
| CN201680003540.2A CN107108717B (zh) | 2015-05-20 | 2016-03-29 | 一种可溶且稳定的异质二聚tcr |
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| CN201510260322.4A CN106279404A (zh) | 2015-05-20 | 2015-05-20 | 一种可溶且稳定的异质二聚tcr |
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| CN201680003540.2A Active CN107108717B (zh) | 2015-05-20 | 2016-03-29 | 一种可溶且稳定的异质二聚tcr |
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| EP (1) | EP3299389A4 (enExample) |
| JP (1) | JP6640994B2 (enExample) |
| CN (2) | CN106279404A (enExample) |
| CA (1) | CA2986273A1 (enExample) |
| WO (1) | WO2016184258A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110016074A (zh) * | 2018-01-08 | 2019-07-16 | 中国科学院广州生物医药与健康研究院 | Mage-a3人源化t细胞受体 |
| WO2021043284A1 (zh) * | 2019-09-05 | 2021-03-11 | 广东香雪精准医疗技术有限公司 | 一种识别ssx2的高亲和力t细胞受体 |
| WO2022002014A1 (zh) | 2020-07-01 | 2022-01-06 | 华夏英泰（北京）生物技术有限公司 | T细胞抗原受体、其多聚体复合物及其制备方法和应用 |
| WO2024131750A1 (zh) | 2022-12-19 | 2024-06-27 | 北京永泰瑞科生物科技有限公司 | T细胞抗原受体及其制备方法和应用 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12020550112A1 (en) * | 2017-09-22 | 2020-10-26 | Wuxi Biologics Ireland Ltd | Novel bispecific polypeptide complexes |
| JP7261307B2 (ja) * | 2019-01-28 | 2023-04-19 | ウーシー バイオロジクス アイルランド リミテッド | 新規二重特異性ｃｄ３／ｃｄ２０ポリペプチド複合体 |
| CN118108833B (zh) * | 2024-03-12 | 2025-05-02 | 缇纱(合肥)生物技术有限公司 | 引入外源二硫键的tcr恒定区及其产品和应用 |
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| PL364734A1 (en) * | 1998-05-19 | 2004-12-13 | Avidex Limited | Soluble t cell receptor |
| WO2000006733A2 (en) * | 1998-07-29 | 2000-02-10 | Heska Corporation | T cell receptor proteins, nucleic acid molecules, and uses thereof |
| WO2003020763A2 (en) * | 2001-08-31 | 2003-03-13 | Avidex Limited | Soluble t cell receptor |
| US6913941B2 (en) * | 2002-09-09 | 2005-07-05 | Freescale Semiconductor, Inc. | SOI polysilicon trench refill perimeter oxide anchor scheme |
| GB0227351D0 (en) * | 2002-11-22 | 2002-12-31 | Isis Innovation | Soluble T-cell receptors |
| WO2004050705A2 (en) * | 2002-12-03 | 2004-06-17 | Avidex Ltd. | Complexes of receptors |
| GB0304068D0 (en) | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
| ATE417065T1 (de) * | 2004-05-19 | 2008-12-15 | Medigene Ltd | Hochaffiner ny-eso-t-zellen-rezeptor |
| MX2007003910A (es) * | 2004-10-01 | 2007-06-07 | Avidex Ltd | Receptores de celulas t que contienen un enlace entre cadenas bisulfuro no nativo ligado a agentes terapeuticos. |
| WO2012013913A1 (en) * | 2010-07-28 | 2012-02-02 | Immunocore Ltd | T cell receptors |
| EP2502934B1 (en) * | 2011-03-24 | 2018-01-17 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Single chain antigen recognizing constructs (scARCs) stabilized by the introduction of novel disulfide bonds |
| EP3015477B1 (en) * | 2013-06-26 | 2021-08-18 | XLifeSc, Ltd. | High-stability t-cell receptor and preparation method and application thereof |
| GB201313377D0 (en) * | 2013-07-26 | 2013-09-11 | Adaptimmune Ltd | T cell receptors |
| GB201314404D0 (en) * | 2013-08-12 | 2013-09-25 | Immunocore Ltd | T Cell Receptors |
-
2015
- 2015-05-20 CN CN201510260322.4A patent/CN106279404A/zh active Pending
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2016
- 2016-03-29 EP EP16795745.5A patent/EP3299389A4/en not_active Withdrawn
- 2016-03-29 CA CA2986273A patent/CA2986273A1/en not_active Abandoned
- 2016-03-29 JP JP2018512466A patent/JP6640994B2/ja not_active Expired - Fee Related
- 2016-03-29 US US15/573,692 patent/US10316087B2/en active Active
- 2016-03-29 CN CN201680003540.2A patent/CN107108717B/zh active Active
- 2016-03-29 WO PCT/CN2016/077680 patent/WO2016184258A1/zh not_active Ceased
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110016074A (zh) * | 2018-01-08 | 2019-07-16 | 中国科学院广州生物医药与健康研究院 | Mage-a3人源化t细胞受体 |
| CN110016074B (zh) * | 2018-01-08 | 2021-03-30 | 中国科学院广州生物医药与健康研究院 | Mage-a3人源化t细胞受体 |
| WO2021043284A1 (zh) * | 2019-09-05 | 2021-03-11 | 广东香雪精准医疗技术有限公司 | 一种识别ssx2的高亲和力t细胞受体 |
| WO2022002014A1 (zh) | 2020-07-01 | 2022-01-06 | 华夏英泰（北京）生物技术有限公司 | T细胞抗原受体、其多聚体复合物及其制备方法和应用 |
| WO2024131750A1 (zh) | 2022-12-19 | 2024-06-27 | 北京永泰瑞科生物科技有限公司 | T细胞抗原受体及其制备方法和应用 |
| EP4624499A1 (en) | 2022-12-19 | 2025-10-01 | Immunotech Applied Science Limited | T-cell antigen receptor, preparation method therefor, and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2986273A1 (en) | 2016-11-24 |
| US10316087B2 (en) | 2019-06-11 |
| EP3299389A1 (en) | 2018-03-28 |
| CN107108717B (zh) | 2021-04-23 |
| JP2018522061A (ja) | 2018-08-09 |
| US20180201682A1 (en) | 2018-07-19 |
| WO2016184258A1 (zh) | 2016-11-24 |
| EP3299389A4 (en) | 2018-11-21 |
| CN107108717A (zh) | 2017-08-29 |
| JP6640994B2 (ja) | 2020-02-05 |
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