CN106268517A - The pressure regulation reactor prepared for Entecavir - Google Patents
The pressure regulation reactor prepared for Entecavir Download PDFInfo
- Publication number
- CN106268517A CN106268517A CN201610659401.7A CN201610659401A CN106268517A CN 106268517 A CN106268517 A CN 106268517A CN 201610659401 A CN201610659401 A CN 201610659401A CN 106268517 A CN106268517 A CN 106268517A
- Authority
- CN
- China
- Prior art keywords
- pressure regulation
- pressure
- valve casing
- spool
- barrel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960000980 entecavir Drugs 0.000 title claims abstract description 19
- YXPVEXCTPGULBZ-WQYNNSOESA-N entecavir hydrate Chemical compound O.C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)C1=C YXPVEXCTPGULBZ-WQYNNSOESA-N 0.000 title claims abstract description 19
- 238000007789 sealing Methods 0.000 claims abstract description 9
- 230000001105 regulatory effect Effects 0.000 claims description 5
- 238000012544 monitoring process Methods 0.000 abstract description 3
- 239000007789 gas Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 239000013067 intermediate product Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229910052756 noble gas Inorganic materials 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
- B01J3/002—Component parts of these vessels not mentioned in B01J3/004, B01J3/006, B01J3/02 - B01J3/08; Measures taken in conjunction with the process to be carried out, e.g. safety measures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
- B01J3/04—Pressure vessels, e.g. autoclaves
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Control Of Fluid Pressure (AREA)
Abstract
The invention discloses the pressure regulation reactor prepared for Entecavir, including kettle and pressure relief device, pressure relief device includes pressure release barrel, valve casing, spool and the elastic component for valve core reset；Being provided with gas channel bottom pressure release barrel, valve casing is sheathed and is fixed on pressure release wall inner portion, forms gap between pressure release barrel and valve casing, and pressure release barrel is provided with steam vent, and steam vent is along pressure release barrel sidewall circumference annular array；Being provided with cavity volume, elastic component and spool inside valve casing to be respectively positioned in cavity volume, cavity volume sidewall is provided with valve opening；The sealing ring preventing gas leakage it is additionally provided with between pressure release barrel and valve casing.The pressure relief device of reactor can be controlled reactor is intrinsic pressure, controls in constant value by intrinsic pressure, it is not necessary to manual operation and monitoring, automatic safe.
Description
Technical field
The present invention relates to reactor, it is the pressure regulation reactor prepared for Entecavir.
Background technology
Entecavir is in the preparation process of reactor, and the intermediate product of generation needs to be filled with noble gas as protection,
This noble gas many employings nitrogen, owing to the intermediate product in reactor can produce other certain gases, therefore when converting
Need to control well reactor internal gas pressure when being filled with nitrogen, anti-impervious liquid.
Want to be released by the gas of overvoltage in time simultaneously, it is ensured that intrinsic pressure suitably, be difficult to ensure that intrinsic pressure owing to manually carrying out pressure release
It is stable at a numerical value, and low during height time intrinsic pressure, and the preparation for Entecavir affects relatively big, and there is certain danger
Property.
Summary of the invention
The goal of the invention of the present invention is to solve the intrinsic pressure problem controlling instability, it is provided that prepare for Entecavir
Pressure regulation reactor, regulator can be controlled reactor is intrinsic pressure, control intrinsic pressure in constant value, and this is constant
Value can follow user concrete condition and lift, it is not necessary to manual operation and monitoring, automatic safe.
In order to realize foregoing invention purpose, present invention employs techniques below scheme: the pressure regulation prepared for Entecavir
Reactor, including kettle and regulator, described regulator includes pressure regulation barrel, valve casing, spool and for valve core reset
Elastic component；Being provided with the gas channel that connect internal with kettle bottom pressure regulation barrel, pressure regulation barrel open top is arranged, and valve casing is sheathed
And it is fixed on pressure regulation wall inner portion, and forming the gap that supply stream passes through between pressure regulation barrel and valve casing, pressure regulation barrel is provided with supply
Multiple steam vents that stream flows out, described steam vent is along pressure regulation barrel sidewall circumference annular array；It is provided with for spool past inside valve casing
Answering the groove of telescopic moving, elastic component and spool are respectively positioned in groove, and described groove sidewall is provided with the valve opening connected with gap, institute
The position limiting structure preventing spool from deviating from it is additionally provided with in stating groove；It is additionally provided with pressure regulating device in described groove；Described pressure regulating device bag
Including the pressure regulation block of cylinder, conflict elastic component bottom described pressure regulation block, pressure regulation block sidewall is connected with groove screw telescopic；Described tune
The sealing ring preventing gas leakage it is additionally provided with between pressure cylinder wall and valve casing.
Preferably, described pressure regulation block top is additionally provided with the square column of convenient twisting, and described square column becomes with pressure regulation block one
Type.
Preferably, described position limiting structure is bulge loop, and described bulge loop is fixed on the inner wall surface of valve casing.
Preferably, described spool includes lead, and lead is located at the top of spool, and spool assumes a " convex " shape, in groove
Being provided with the gathering sill embedded for lead, return unit is spring, and lead sidewall is located at by spring housing.
Preferably, described valve casing outer wall is threaded connection with the inwall of pressure regulation barrel.
Preferably, described pressure regulation barrel inwall is provided with female thread, and valve casing outer wall is provided with external screw thread, described external screw thread and interior spiral shell
Stricture of vagina engages.
Preferably, described pressure regulation block side surface is provided with external screw thread, and the groove in valve casing 1 is provided with and coordinates with pressure regulation block external screw thread
Female thread.
Compared with prior art, have employed the pressure regulation reactor prepared for Entecavir of technique scheme, have
Following beneficial effect:
One, using the pressure regulation reactor prepared for Entecavir of the present invention, the spool in regulator can be by gas
Having beared down on one, when spool is by high pressure jack-up, valve opening is opened, and is connected with gap by the gas channel in valve casing, gap and then general
The gas released sheds in steam vent.
Owing to spool can be controlled by elastic component, and it is to use elastic component to be controlled, therefore when intrinsic pressure slightly larger
When elastic pressure, valve opening can be opened, and quickly reactor internal high pressure is carried out pressure release, when intrinsic pressure less than elastic pressure
Time, spool sets back and is closed by valve opening, reaching the effect of pressure control voltage stabilizing.
Whole-process automatic, it is not necessary to personal monitoring and manual operation, safety is good, and automaticity is high.
Two, pressure regulating device, can adjust between pressure regulation block and spool by rotating the screw thread between pressure regulation block and groove
Spacing, is indirectly controlled the decrement of elastic component: when pressing under pressure regulation block, and elastic component decrement is big, and elastic component is to spool
Bounce big, the air pressure needed for reactor intrinsic pressure promotion spool opens valve opening is higher, and reactor is intrinsic pressure to be controlled in higher pressure
In strong；Reversely regulation pressure regulation block, pressure regulation block is up, and elastic component decrement reduces, and the bounce of spool is reduced by elastic component, reaction
Still intrinsic pressure promotion spool opens the air pressure step-down needed for valve opening, and reactor is intrinsic pressure to be controlled in relatively low pressure.
Accompanying drawing explanation
Fig. 1 is the structural representation of the pressure regulation reactor embodiment that the present invention is prepared for Entecavir；
Fig. 2 is the structural representation of regulator in the present invention；
Fig. 3 is the sectional view of Fig. 2；
Fig. 4 is the sectional view (valve opening closed mode) of regulator in the present invention；
Fig. 5 is the sectional view (valve opening opening) of regulator in the present invention；
Fig. 6 is the sectional view of valve casing in the present invention；
Fig. 7 is the sectional view of pressure regulation barrel in the present invention.
Reference: 1, valve casing；10, valve opening；11, groove；110, gathering sill；12, external screw thread；13, bulge loop；2, spool；
20, lead；3, pressure regulation barrel；30, gap；31, steam vent；32, female thread；41, top sealing ring；42, bottom sealing ring.
Detailed description of the invention
Below in conjunction with the accompanying drawings the present invention is described further.
Such as Fig. 1 to the pressure regulation reactor prepared for Entecavir shown in 7, including kettle and regulator B, pressure regulation fills
Put B and include pressure regulation barrel 3, valve casing 1, spool 2 and spring.
As it is shown in fig. 7, be provided with the gas channel that connect internal with kettle, pressure regulation barrel 3 open top bottom pressure regulation barrel 3
Arranging, valve casing 1 is sheathed and is fixed on pressure regulation barrel 3 inside, forms the gap that supply stream passes through between pressure regulation barrel 3 and valve casing 1
30, pressure regulation barrel 3 is provided with the multiple steam vents 31 flowed out for air-flow, and steam vent 31 is along pressure regulation barrel 3 sidewall circumference annular array.
Spool in regulator can be by air pressure jack-up, and when spool is by high pressure jack-up, valve opening is opened, by valve casing
Gas channel is connected with gap, gap and then shed in steam vent by the gas released.
Owing to spool can be controlled by elastic component, and it is to use elastic component to be controlled, therefore when intrinsic pressure slightly larger
When elastic pressure, valve opening can be opened, and quickly reactor internal high pressure is carried out pressure regulation, when intrinsic pressure less than elastic pressure
Time, spool sets back and is closed by valve opening, reaching the effect of pressure control voltage stabilizing.
Steam vent 31 arranges and along pressure regulation barrel 3 axle center array in the form of a ring in pressure regulation barrel 3 sidewall.Owing to high velocity air exists
When small holes or gap, air can be made to produce friction and vibrate, thus produce noise.Therefore, the present embodiment is by pressure regulation
Set up multiple thickly dotted steam vent on barrel 3, eliminate fricative phenomenon, reduce noise, make production environment the quietest.
Valve casing 1 outer wall is threaded connection with the inwall of pressure regulation barrel 3.Pressure regulation barrel 3 inwall is provided with female thread, valve casing 1
Outer wall is provided with external screw thread, and external screw thread engages with female thread.By screwed tight, valve casing 1 is rigidly secured to pressure regulation barrel 3
In.
As shown in Figure 6, valve casing 1 is internal is provided with the groove 11 moved for spool 2 reciprocal telescopic, and spring and spool 2 are respectively positioned on
In groove 11, groove 11 sidewall is provided with the valve opening 10 connected with gap 30, and groove 11 inner wall surface is additionally provided with bulge loop 13.Bulge loop 13
Effect be, spool, when by spring fight back in situ, can play a spacing effect, prevents spool from deviating from groove, makes
Control valve is become to lose efficacy.
Due to pressure regulation barrel 3 with valve casing 1 when docking, still there is gap, many places, therefore pressure regulation barrel 3 and valve casing 1 it
Between be additionally provided with prevent gas leakage top sealing ring 41 and bottom sealing ring 42.At two, the effect of sealing ring is, it is possible to coordinates and adjusts
Pressure cylinder wall 3 and valve casing 1 tighten effect, pressing sealing ring card jail tightly down in gap by valve casing 1, improve tightness,
Avoid air-flow to overflow in gap, noise occurs.
It is additionally provided with the pressure regulation block 5 of cylinder in groove, conflicts with spring bottom pressure regulation block 5, pressure regulation block 5 sidewall and groove spiral shell
Stricture of vagina is flexible to be connected；Pressure regulation block sidewall is provided with external screw thread, is provided with the female thread coordinated with pressure regulation block external screw thread in groove.
The spacing between pressure regulation block and spool can be adjusted, indirectly by rotating the screw thread between pressure regulation block and groove
Being controlled the decrement of elastic component: when pressing under pressure regulation block, elastic component decrement is big, and elastic component is big to the bounce of spool,
Air pressure needed for reactor intrinsic pressure promotion spool opens valve opening is higher, and reactor is intrinsic pressure to be controlled in higher pressure；Reversely adjust
Joint pressure regulation block, pressure regulation block is up, and elastic component decrement reduces, and the bounce of spool is reduced by elastic component, the intrinsic pressure promotion of reactor
Spool opens the air pressure step-down needed for valve opening, and reactor is intrinsic pressure to be controlled in relatively low pressure.
Spool 2 includes lead 20, and lead 20 is located at the top of spool 2, and spool 2 assumes a " convex " shape, and sets in pressure regulation block 5
Having the gathering sill 110 embedded for lead 20, return unit is spring, and lead 20 sidewall is located at by spring housing.
Lead 20 has two functions: first, is for keeping the spool direction when sliding, it is ensured that spool can edge
The axis direction of valve casing slides, and prevents skew, it is to avoid dislocation；Secondly, sheathed for spring, plays a limit to spring
Position effect, prevents spring from use offseting.
The above is the preferred embodiment of the present invention, for the person of ordinary skill of the art without departing from this
On the premise of bright principle, it is also possible to make some modification and improvement, these also should be regarded as protection scope of the present invention.
Claims (7)
1. the pressure regulation reactor prepared for Entecavir, it is characterised in that: include kettle and regulator (B), described pressure regulation
Device (B) includes pressure regulation barrel (3), valve casing (1), spool (2) and the elastic component resetted for spool (2)；
-pressure regulation barrel (3) bottom is provided with the gas channel that connect internal with kettle, and pressure regulation barrel (3) open top is arranged, valve casing
(1) sheathed and to be fixed on pressure regulation barrel (3) internal, form supply between pressure regulation barrel (3) and valve casing (1) and flow the gap passed through
(30), pressure regulation barrel (3) is provided with the multiple steam vents (31) flowed out for air-flow, and described steam vent (31) is along pressure regulation barrel (3) side
Wall circumference annular array；
-valve casing (1) is internal is provided with the groove (11) moved for spool (2) reciprocal telescopic, and elastic component and spool (2) are respectively positioned on groove
(11), in, described groove (11) sidewall is provided with the valve opening (10) connected with gap (30), is additionally provided with and prevents in described groove (11)
The position limiting structure that spool (2) is deviate from；It is additionally provided with pressure regulating device in described groove；
-described pressure regulating device includes the pressure regulation block (5) of cylinder, described pressure regulation block (5) bottom conflict elastic component, pressure regulation block (5)
Sidewall is connected with groove screw telescopic；
-it is additionally provided with the sealing ring (41,42) preventing gas leakage between described pressure regulation barrel (3) and valve casing (1).
The pressure regulation reactor prepared for Entecavir the most according to claim 1, it is characterised in that: described pressure regulation block
(5) top is additionally provided with the square column of convenient twisting, and described square column is one-body molded with pressure regulation block (5).
The pressure regulation reactor prepared for Entecavir the most according to claim 1, it is characterised in that: described position limiting structure
For bulge loop (13), described bulge loop (13) is fixed on the inner wall surface of valve casing (1).
The pressure regulation reactor prepared for Entecavir the most according to claim 1, it is characterised in that: described spool (2)
Including lead (20), lead (20) is located at the top of spool (2), and spool (2) assumes a " convex " shape, and groove is provided with confession in (11)
The gathering sill (110) that lead (20) embeds, return unit is spring, and lead (20) sidewall is located at by spring housing.
The pressure regulation reactor prepared for Entecavir the most according to claim 1, it is characterised in that: described valve casing (1)
Outer wall is threaded connection with the inwall of pressure regulation barrel (3).
The pressure regulation reactor prepared for Entecavir the most according to claim 5, it is characterised in that: described pressure regulation barrel
(3) inwall is provided with female thread, and valve casing (1) outer wall is provided with external screw thread, and described external screw thread engages with female thread.
The pressure regulation reactor prepared for Entecavir the most according to claim 1, it is characterised in that: described pressure regulation block
(5) side surface is provided with external screw thread, and the groove (11) in valve casing 1 is provided with the female thread coordinated with pressure regulation block external screw thread.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610659401.7A CN106268517A (en) | 2016-08-12 | 2016-08-12 | The pressure regulation reactor prepared for Entecavir |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610659401.7A CN106268517A (en) | 2016-08-12 | 2016-08-12 | The pressure regulation reactor prepared for Entecavir |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106268517A true CN106268517A (en) | 2017-01-04 |
Family
ID=57669546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610659401.7A Pending CN106268517A (en) | 2016-08-12 | 2016-08-12 | The pressure regulation reactor prepared for Entecavir |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106268517A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5967177A (en) * | 1995-12-22 | 1999-10-19 | Robert Bosch Gmbh | Pressure regulating valve |
| CN2448235Y (en) * | 2000-11-22 | 2001-09-19 | 容祥寿 | Pressure adjustable automatic electric pressure cooker |
| CN102032372A (en) * | 2010-12-20 | 2011-04-27 | 福田雷沃国际重工股份有限公司 | Pressure relief and noise reduction safety valve |
| CN104389677A (en) * | 2014-11-25 | 2015-03-04 | 浙江吉利汽车研究院有限公司 | Noise reduction structure of supercharger |
| CN204619956U (en) * | 2014-12-24 | 2015-09-09 | 江苏常州酞青新材料科技有限公司 | A kind of novel reaction kettle |
| CN205423356U (en) * | 2016-02-27 | 2016-08-03 | 山推工程机械股份有限公司 | Pressurization formula hydraulic tank respirator |
-
2016
- 2016-08-12 CN CN201610659401.7A patent/CN106268517A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5967177A (en) * | 1995-12-22 | 1999-10-19 | Robert Bosch Gmbh | Pressure regulating valve |
| CN2448235Y (en) * | 2000-11-22 | 2001-09-19 | 容祥寿 | Pressure adjustable automatic electric pressure cooker |
| CN102032372A (en) * | 2010-12-20 | 2011-04-27 | 福田雷沃国际重工股份有限公司 | Pressure relief and noise reduction safety valve |
| CN104389677A (en) * | 2014-11-25 | 2015-03-04 | 浙江吉利汽车研究院有限公司 | Noise reduction structure of supercharger |
| CN204619956U (en) * | 2014-12-24 | 2015-09-09 | 江苏常州酞青新材料科技有限公司 | A kind of novel reaction kettle |
| CN205423356U (en) * | 2016-02-27 | 2016-08-03 | 山推工程机械股份有限公司 | Pressurization formula hydraulic tank respirator |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170104 |
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| RJ01 | Rejection of invention patent application after publication |