CN106267895B - Fill column device and dress column system - Google Patents

Fill column device and dress column system Download PDF

Info

Publication number
CN106267895B
CN106267895B CN201510245419.8A CN201510245419A CN106267895B CN 106267895 B CN106267895 B CN 106267895B CN 201510245419 A CN201510245419 A CN 201510245419A CN 106267895 B CN106267895 B CN 106267895B
Authority
CN
China
Prior art keywords
column
chromatographic column
vibrating member
dress
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201510245419.8A
Other languages
Chinese (zh)
Other versions
CN106267895A (en
Inventor
陈应庄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hunan Normal University
Original Assignee
Hunan Normal University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hunan Normal University filed Critical Hunan Normal University
Priority to CN201510245419.8A priority Critical patent/CN106267895B/en
Publication of CN106267895A publication Critical patent/CN106267895A/en
Application granted granted Critical
Publication of CN106267895B publication Critical patent/CN106267895B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

The present invention relates to a kind of dress column devices, and for the filler of chromatographic column, the dress column device includes vibrating member, and the vibrating member is contacted with the lateral wall of the chromatographic column to be vibrated to the chromatographic column, and the vibrating member can be moved up and down with respect to chromatographic column.Above-mentioned dress column device vibrates chromatographic column since vibrating member is contacted with the lateral wall of chromatographic column so that the filler of chromatographic column was not only closely knit but also uniform, and since vibrating member can be moved up and down with respect to chromatographic column, the column bed for realizing chromatographic column was not only closely knit but also uniform.Above-mentioned dress column device, stationary phase filling packed uniform, column bed are stablized, so as to which with higher separative efficiency and preferable experimental repeatability, the dry column especially suitable for chromatographic column fills column method filler.

Description

Fill column device and dress column system
Technical field
The present invention relates to the device field of chromatographic column filling, more particularly to a kind of dress column device and dress column system.
Background technology
Chromatography technology, also referred to as chromatographic separation technology are a kind of laboratory and the common species analysis of industrial production And separation means, for example be required in organic synthesis, Natural products research using chromatography technology.Chromatography technology is adopted Fill stationary phase with chromatographic column, mixture to be separated with mobile phase by stationary phase, due to stationary phase and substance to be separated not The same mechanism of action makes substance to be separated according to different retention time sequence outflow chromatographic columns, so as to reach separation and divide The purpose of analysis.
At present, the dress column of chromatographic column is common wet method dress post and dry column-packing two ways.Wherein, dry column-packing be It fills column and does not have to solvent dilution stationary phase in the process, stationary phase is entered by gravity in chromatographic column in a manner of solid powder, and profit Ensure the density between stationary phase with itself gravity or impressed pressure.But dry column-packing is in filling process generally use Soft material beats chromatographic column so that the column bed of chromatographic column is closely knit, and due to the heterogeneity beaten, cause to load it is uneven and Influence separating effect.
Invention content
Based on this, it is necessary to which the stationary phase for providing a kind of chromatographic column loads uniform dress column device and dress column system.
A kind of dress column device, for the filler of chromatographic column, it is described dress column device include vibrating member, the vibrating member with it is described The lateral wall of chromatographic column contacts to vibrate the chromatographic column, and the vibrating member can be moved up and down with respect to chromatographic column.
Above-mentioned dress column device vibrates chromatographic column since vibrating member is contacted with the lateral wall of chromatographic column so that chromatography The filler of column was not only closely knit but also uniform, and since vibrating member can be moved up and down with respect to chromatographic column, the column bed for realizing chromatographic column was both close It is real and uniform.Above-mentioned dress column device, stationary phase filling packed uniform, column bed are stablized, so as to higher separative efficiency and compared with Good experimental repeatability, the dry column especially suitable for chromatographic column fill column method filler.
The dress column device includes multiple vibrating members in one of the embodiments, and multiple vibrating members are in institute Chromatographic column described in stating the sustained height upper edge of chromatographic column is axially uniformly arranged.
The dress column device further includes regulating part in one of the embodiments, and the regulating part is set on two neighboring institute Between stating vibrating member, the regulating part makes the close trend of the oriented chromatographic column of the vibrating member, so as to adjust the vibration Active force between the lateral wall of part and the chromatographic column.
The dress column device further includes first support in one of the embodiments, and the vibrating member is movably disposed in In the first support, so as to make the vibrating member can relatively described chromatographic column move up and down.
The dress column device further includes second support in one of the embodiments, and the vibrating member is arranged on described the On two stents, the vibrating member is connect by the second support with the first support, the second support and the vibration The relatively described chromatographic column of part, which synchronizes, to be moved up and down.
The vibrating member and the second support are in the sustained height of the chromatographic column in one of the embodiments, On, the vibrating member is between the second support and the chromatographic column.
The dress column device further includes adjustment portion and fixing piece in one of the embodiments, and the adjustment portion, which is fixed, to be connected The vibrating member is connected to, and is movably attached to the fixing piece, the fixing piece is fixedly connected on the second support, leads to The position of the relatively described fixing piece of the adjustment portion is overregulated, the distance between the vibrating member and second support is adjusted, from And make multiple vibrating members different from the distance at the chromatographic column center.
The vibrating member is equipped with handheld terminal in one of the embodiments, holds the handheld terminal, makes the vibrating member can Relatively described chromatographic column moves up and down.
The dress column device further includes cushion pad in one of the embodiments, and the cushion pad is set on the vibrating member Between the lateral wall of the chromatographic column.
A kind of dress column system, including chromatographic column, filler conduit, vacuum extractor, third stent and above-mentioned dress column device, The chromatographic column is set on the third stent, and the vibrating member of the dress column device is contacted with the lateral wall of the chromatographic column To be vibrated to the chromatographic column, and the vibrating member can be moved up and down with respect to chromatographic column, one end of the filler conduit with Filler to be installed is inserted into the upper end connection of the chromatographic column, the other end, and the lower end of the chromatographic column connects with the vacuum extractor It connects.
Description of the drawings
Fig. 1 is the structure diagram of the dress column system of an embodiment;
Fig. 2 is the part-structure schematic diagram of the dress column device of dress column system shown in FIG. 1.
Specific embodiment
For the ease of understanding the present invention, the present invention is described more fully below with reference to relevant drawings.In attached drawing Give the preferred embodiment of the present invention.But the present invention can realize in many different forms, however it is not limited to herein Described embodiment.On the contrary, the purpose for providing these embodiments is to make the understanding to the disclosure more saturating It is thorough comprehensive.
It should be noted that when element is referred to as " being fixed on " another element, it can be directly on another element Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it can be directly connected to To another element or it may be simultaneously present centering elements.Term as used herein " vertical ", " horizontal ", " left side ", " right side " and similar statement are for illustrative purposes only.
With reference to Fig. 1, the dress column device 100 of an embodiment, for the filler of chromatographic column 200, dress column device 100 includes shaking Moving part 110, vibrating member 110 are contacted with the lateral wall of chromatographic column 200 to be vibrated to chromatographic column 20, and vibrating member 110 can phase Chromatographic column 200 is moved up and down.
Above-mentioned dress column device 100 contacts with the lateral wall of chromatographic column 200 outside to chromatographic column 200 due to vibrating member 110 Wall is vibrated so that the filler of chromatographic column 200 was not only closely knit but also uniform, and since vibrating member 110 can be with respect to chromatographic column about 200 Mobile, the column bed for realizing chromatographic column 200 was not only closely knit but also uniform.Above-mentioned dress column device 100, stationary phase filling packed uniform, column Bed is stablized, so as to which with higher separative efficiency and preferable experimental repeatability, the dry column especially suitable for chromatographic column 200 fills column Method filler.
Dress column device 100 includes multiple vibrating members 110 in one of the embodiments, and multiple vibrating member 110 is chromatographing The sustained height upper edge chromatographic column 200 of column 200 is circumferential to be uniformly arranged.Therefore, the filler that can further promote chromatographic column 200 is closely knit Degree and the uniformity.In the present embodiment, vibrating member 110 is three.
It is appreciated that vibrating member 110 directly can be contacted uniformly for annular with the lateral wall of chromatographic column 200, make chromatography The filler of column 200 was not only closely knit but also uniform.
Dress column device 100 further includes first support 120 in one of the embodiments, and vibrating member 110 is movably disposed in In first support 120, so as to make vibrating member 110 that can be moved up and down with respect to chromatographic column 200.Particularly, first support 120, which is equipped with, rises Falling unit 121, lifting gear 121 is movably arranged at first support 120, and is fixedly connected with vibrating member 110, lifting gear 121 can drive vibrating member 110 to be moved up and down with respect to chromatographic column 200.
It is appreciated that vibrating member 110 can be equipped with handheld terminal, the handheld terminal is held, makes vibrating member 110 can be with respect to chromatographic column 200 move up and down, the so convenient application the narrow and small place or small test situations such as.
Specifically, vibrating member 110 is the device that can provide vibration source.More specifically, in the present embodiment, vibrating member 110 For vibrator.Specifically, in the present embodiment, vibrating member 110 is dither.
With reference to Fig. 2, particularly, dress column device 100 further includes regulating part 130, and regulating part 130 is set on two neighboring vibrating member Between 110, regulating part 130 makes the close trend of 110 oriented chromatographic column of vibrating member, so as to adjust vibrating member 110 and chromatographic column 200 Lateral wall between active force, when filling column vibrating member 110 can so contacted with the lateral wall of chromatographic column 200 closer, Vibrating member 110 is more effective to the vibration of chromatographic column 200, further promotes the density of filler.Specifically, regulating part 130 is bullet Property part.More specifically, regulating part 130 is spring.
Dress column device 100 further includes second support 140 in one of the embodiments, and vibrating member 110 is arranged on second On frame 140, and vibrating member 110 is connect by second support 140 with first support 120,110 phase of second support 140 and vibrating member Chromatographic column 200 is synchronized and is moved up and down.Specifically, in the present embodiment, second support 140 is annular ring.
Particularly, with second support 140 on the sustained height of chromatographic column 200, vibrating member 110 is located at vibrating member 110 Between second support 140 and chromatographic column 200.
In a wherein embodiment, dress column device 100 further includes adjustment portion 111 and fixing piece 112, and adjustment portion 111 is fixed Vibrating member 110 is connected to, and is movably attached to fixing piece 112, fixing piece 112 is fixedly connected on second support 140, passes through The position of 111 opposed fixed member 112 of adjustment portion is adjusted, the distance between vibrating member 110 and second support 140 is adjusted, so as to Make multiple vibrating members 110 different from the distance at 200 center of chromatographic column so that dress column device 100 is adapted in different-diameter range Chromatographic column 200, be particularly suitable for the filling of industry major diameter chromatographic column 200, solve soft material and beat uneven, effect not Good, the problem of labor intensity is big.
Specifically, adjustabel part 111 is fixed link, and fixing piece 112 is fixed sleeving, and fixing piece 112 is sleeved on adjustabel part 111 On.
In a wherein embodiment, dress column device 100 further includes cushion pad 150, cushion pad 150 be set on vibrating member 110 with To protect chromatographic column 200 between the lateral wall of chromatographic column 200.Specifically, cushion pad 150 is rubber pad.
With continued reference to Fig. 1, the dress column system 10 of an embodiment, including chromatographic column 200, filler conduit 300, vacuum means 400, third stent 500 and above-mentioned dress column device 100 are put, chromatographic column 200 is set on third stent 500, dress column device 100 Vibrating member 110 is contacted with the lateral wall of chromatographic column 200 to be vibrated to chromatographic column 20, and vibrating member 110 can be with respect to chromatographic column 200 move up and down, and one end of filler conduit 300 is connect with the upper end of chromatographic column 200, the other end is inserted into filler to be installed, chromatography The lower end of column 200 is connect with vacuum extractor 400.
Above-mentioned dress column system 10, using above-mentioned dress column device 100, the column bed for realizing chromatographic column 200 was not only uniform but also close Real, column bed is stablized, so as to have higher separative efficiency and preferable experimental repeatability, applied to organic synthesis, natural products During waiting research process chromatography, the dry column especially suitable for chromatographic column 200 fills column method filler.In addition, due to vacuumizing Device 400 is connect with chromatographic column 200, and filler is made to be entered in chromatographic column 200 from filler conduit 300, and the nothing for realizing filler is let out Dress is failed to fill in, avoids and powdered stationary phase is poured into harm of the airborne dust generated during chromatographic column 200 to operating personnel.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, it is all considered to be the range of this specification record.
Embodiment described above only expresses the several embodiments of the present invention, and description is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that those of ordinary skill in the art are come It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.

Claims (6)

1. a kind of dress column device, which is characterized in that for the filler of chromatographic column, it is described dress column device include vibrating member, first Frame and second support, the vibrating member is contacted with the lateral wall of the chromatographic column to be vibrated to the chromatographic column, described to shake Moving part is arranged in the second support, and the vibrating member is connect by the second support with the first support, described to shake On the sustained height of the chromatographic column, the vibrating member is located at the second support and described for moving part and the second support Between chromatographic column, the second support and the relatively described chromatographic column of the vibrating member synchronize move up and down;
The dress column device further includes adjustment portion and fixing piece, and the adjustment portion is fixedly connected on the vibrating member, and moves Ground is connected to the fixing piece, and the fixing piece is fixedly connected on the second support, by adjusting the adjustment portion with respect to institute The position of fixing piece is stated, the distance between the vibrating member and second support is adjusted, so as to make multiple vibrating members and institute The distance for stating chromatographic column center is different.
2. dress column device according to claim 1, which is characterized in that the dress column device includes multiple vibrating members, Chromatographic column described in sustained height upper edge of multiple vibrating members in the chromatographic column is axially uniformly arranged.
3. dress column device according to claim 2, which is characterized in that the dress column device further includes regulating part, the tune It saves part to be set between the two neighboring vibrating member, the regulating part makes the oriented chromatographic column of the vibrating member is close to become Gesture, so as to adjust the active force between the vibrating member and the lateral wall of the chromatographic column.
4. dress column device according to claim 1, which is characterized in that the vibrating member is equipped with handheld terminal, holds the hand Hold end, make the vibrating member can relatively described chromatographic column move up and down.
5. dress column device according to claim 1, which is characterized in that the dress column device further includes cushion pad, described slow Punching pad is set between the vibrating member and the lateral wall of the chromatographic column.
6. a kind of dress column system, which is characterized in that will including chromatographic column, filler conduit, vacuum extractor, third stent and right 1~5 any one of them is asked to fill column device, the chromatographic column is set on the third stent, and the described of dress column device shakes Moving part is contacted with the lateral wall of the chromatographic column to be vibrated to the chromatographic column, and the vibrating member can be with respect on chromatographic column Lower movement, one end of the filler conduit is connect with the upper end of the chromatographic column, the other end is inserted into filler to be installed, the chromatography The lower end of column is connect with the vacuum extractor.
CN201510245419.8A 2015-05-14 2015-05-14 Fill column device and dress column system Active CN106267895B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510245419.8A CN106267895B (en) 2015-05-14 2015-05-14 Fill column device and dress column system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510245419.8A CN106267895B (en) 2015-05-14 2015-05-14 Fill column device and dress column system

Publications (2)

Publication Number Publication Date
CN106267895A CN106267895A (en) 2017-01-04
CN106267895B true CN106267895B (en) 2018-06-26

Family

ID=57631051

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510245419.8A Active CN106267895B (en) 2015-05-14 2015-05-14 Fill column device and dress column system

Country Status (1)

Country Link
CN (1) CN106267895B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109939464A (en) * 2019-03-26 2019-06-28 闽江学院 Portable chromatographic column charging vibrator
CN115337672A (en) * 2022-08-05 2022-11-15 藤蔬生物科技(嘉兴)有限公司 Matrix chromatography device and application method thereof in preparation of flavonoid compound

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2476320Y (en) * 2001-04-29 2002-02-13 丁志坚 Device for filling flexible material into chromatography column
CN201692690U (en) * 2010-04-23 2011-01-05 聊城万合工业制造有限公司 Multi-dimensional oscillating mechanism for chromatographic column main body
CN203663497U (en) * 2013-10-21 2014-06-25 苏州宝化炭黑有限公司 Packing chromatographic column preparing device
CN103071313B (en) * 2007-03-09 2016-03-23 通用电气健康护理生物科学股份公司 For loading system and the method for chromatographic column

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030146159A1 (en) * 2002-02-06 2003-08-07 Guiochon Georges A. Method and apparatus to pack high efficiency columns for chromatography

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2476320Y (en) * 2001-04-29 2002-02-13 丁志坚 Device for filling flexible material into chromatography column
CN103071313B (en) * 2007-03-09 2016-03-23 通用电气健康护理生物科学股份公司 For loading system and the method for chromatographic column
CN201692690U (en) * 2010-04-23 2011-01-05 聊城万合工业制造有限公司 Multi-dimensional oscillating mechanism for chromatographic column main body
CN203663497U (en) * 2013-10-21 2014-06-25 苏州宝化炭黑有限公司 Packing chromatographic column preparing device

Also Published As

Publication number Publication date
CN106267895A (en) 2017-01-04

Similar Documents

Publication Publication Date Title
CN106267895B (en) Fill column device and dress column system
MX354707B (en) Apparatus and method for separating solids from a solids laden drilling fluid.
MX2020012724A (en) Egg support assembly, and associated device and method.
CN102180274A (en) Vibrating platform for material filling equipment
CN204142463U (en) A kind of novel mobile phone drop machine
US4664790A (en) Method for screening of wooden chips and the like and a screen
GB1027137A (en) Vibratory screening machine
CN207114301U (en) A kind of beam type fatigue experimental device
JP5245979B2 (en) Sieving equipment
ATE199843T1 (en) VIBRATION CONE CRUSHER
CN206519334U (en) A kind of food processing sieve material device
CN105334016A (en) Mobile phone drop test machine
CN104819875B (en) Uniform sample loading device
RU123350U1 (en) VIBRATION MULTI-YEAR SCREEN FOR SORTING FINE GRAIN MATERIALS
CN205785880U (en) A kind of block sampling, sizing all-in-one
CN206483688U (en) Medicine shakes screen device
CN212861923U (en) Vibration packaging machine
CN103196760A (en) Portable and adjustable inertial loading experiment device
CN202823862U (en) Multi-function feed sieving device
JP4862729B2 (en) Chromatographic column support pressure device and chromatography device
JP2007106532A (en) Vibration control device and vibratory conveyor
RU2015100819A (en) FREQUENCY PACKAGE OF ELASTIC KOCHETOV ELEMENTS
RU2015100847A (en) DRIVE VIBRATION INSULATOR
CN204470097U (en) A kind of oscillating sieving machine
CN204933513U (en) A kind of dust-proof rack for test tube

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant