CN106267895B - Fill column device and dress column system - Google Patents
Fill column device and dress column system Download PDFInfo
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- CN106267895B CN106267895B CN201510245419.8A CN201510245419A CN106267895B CN 106267895 B CN106267895 B CN 106267895B CN 201510245419 A CN201510245419 A CN 201510245419A CN 106267895 B CN106267895 B CN 106267895B
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Abstract
The present invention relates to a kind of dress column devices, and for the filler of chromatographic column, the dress column device includes vibrating member, and the vibrating member is contacted with the lateral wall of the chromatographic column to be vibrated to the chromatographic column, and the vibrating member can be moved up and down with respect to chromatographic column.Above-mentioned dress column device vibrates chromatographic column since vibrating member is contacted with the lateral wall of chromatographic column so that the filler of chromatographic column was not only closely knit but also uniform, and since vibrating member can be moved up and down with respect to chromatographic column, the column bed for realizing chromatographic column was not only closely knit but also uniform.Above-mentioned dress column device, stationary phase filling packed uniform, column bed are stablized, so as to which with higher separative efficiency and preferable experimental repeatability, the dry column especially suitable for chromatographic column fills column method filler.
Description
Technical field
The present invention relates to the device field of chromatographic column filling, more particularly to a kind of dress column device and dress column system.
Background technology
Chromatography technology, also referred to as chromatographic separation technology are a kind of laboratory and the common species analysis of industrial production
And separation means, for example be required in organic synthesis, Natural products research using chromatography technology.Chromatography technology is adopted
Fill stationary phase with chromatographic column, mixture to be separated with mobile phase by stationary phase, due to stationary phase and substance to be separated not
The same mechanism of action makes substance to be separated according to different retention time sequence outflow chromatographic columns, so as to reach separation and divide
The purpose of analysis.
At present, the dress column of chromatographic column is common wet method dress post and dry column-packing two ways.Wherein, dry column-packing be
It fills column and does not have to solvent dilution stationary phase in the process, stationary phase is entered by gravity in chromatographic column in a manner of solid powder, and profit
Ensure the density between stationary phase with itself gravity or impressed pressure.But dry column-packing is in filling process generally use
Soft material beats chromatographic column so that the column bed of chromatographic column is closely knit, and due to the heterogeneity beaten, cause to load it is uneven and
Influence separating effect.
Invention content
Based on this, it is necessary to which the stationary phase for providing a kind of chromatographic column loads uniform dress column device and dress column system.
A kind of dress column device, for the filler of chromatographic column, it is described dress column device include vibrating member, the vibrating member with it is described
The lateral wall of chromatographic column contacts to vibrate the chromatographic column, and the vibrating member can be moved up and down with respect to chromatographic column.
Above-mentioned dress column device vibrates chromatographic column since vibrating member is contacted with the lateral wall of chromatographic column so that chromatography
The filler of column was not only closely knit but also uniform, and since vibrating member can be moved up and down with respect to chromatographic column, the column bed for realizing chromatographic column was both close
It is real and uniform.Above-mentioned dress column device, stationary phase filling packed uniform, column bed are stablized, so as to higher separative efficiency and compared with
Good experimental repeatability, the dry column especially suitable for chromatographic column fill column method filler.
The dress column device includes multiple vibrating members in one of the embodiments, and multiple vibrating members are in institute
Chromatographic column described in stating the sustained height upper edge of chromatographic column is axially uniformly arranged.
The dress column device further includes regulating part in one of the embodiments, and the regulating part is set on two neighboring institute
Between stating vibrating member, the regulating part makes the close trend of the oriented chromatographic column of the vibrating member, so as to adjust the vibration
Active force between the lateral wall of part and the chromatographic column.
The dress column device further includes first support in one of the embodiments, and the vibrating member is movably disposed in
In the first support, so as to make the vibrating member can relatively described chromatographic column move up and down.
The dress column device further includes second support in one of the embodiments, and the vibrating member is arranged on described the
On two stents, the vibrating member is connect by the second support with the first support, the second support and the vibration
The relatively described chromatographic column of part, which synchronizes, to be moved up and down.
The vibrating member and the second support are in the sustained height of the chromatographic column in one of the embodiments,
On, the vibrating member is between the second support and the chromatographic column.
The dress column device further includes adjustment portion and fixing piece in one of the embodiments, and the adjustment portion, which is fixed, to be connected
The vibrating member is connected to, and is movably attached to the fixing piece, the fixing piece is fixedly connected on the second support, leads to
The position of the relatively described fixing piece of the adjustment portion is overregulated, the distance between the vibrating member and second support is adjusted, from
And make multiple vibrating members different from the distance at the chromatographic column center.
The vibrating member is equipped with handheld terminal in one of the embodiments, holds the handheld terminal, makes the vibrating member can
Relatively described chromatographic column moves up and down.
The dress column device further includes cushion pad in one of the embodiments, and the cushion pad is set on the vibrating member
Between the lateral wall of the chromatographic column.
A kind of dress column system, including chromatographic column, filler conduit, vacuum extractor, third stent and above-mentioned dress column device,
The chromatographic column is set on the third stent, and the vibrating member of the dress column device is contacted with the lateral wall of the chromatographic column
To be vibrated to the chromatographic column, and the vibrating member can be moved up and down with respect to chromatographic column, one end of the filler conduit with
Filler to be installed is inserted into the upper end connection of the chromatographic column, the other end, and the lower end of the chromatographic column connects with the vacuum extractor
It connects.
Description of the drawings
Fig. 1 is the structure diagram of the dress column system of an embodiment；
Fig. 2 is the part-structure schematic diagram of the dress column device of dress column system shown in FIG. 1.
Specific embodiment
For the ease of understanding the present invention, the present invention is described more fully below with reference to relevant drawings.In attached drawing
Give the preferred embodiment of the present invention.But the present invention can realize in many different forms, however it is not limited to herein
Described embodiment.On the contrary, the purpose for providing these embodiments is to make the understanding to the disclosure more saturating
It is thorough comprehensive.
It should be noted that when element is referred to as " being fixed on " another element, it can be directly on another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it can be directly connected to
To another element or it may be simultaneously present centering elements.Term as used herein " vertical ", " horizontal ", " left side ",
" right side " and similar statement are for illustrative purposes only.
With reference to Fig. 1, the dress column device 100 of an embodiment, for the filler of chromatographic column 200, dress column device 100 includes shaking
Moving part 110, vibrating member 110 are contacted with the lateral wall of chromatographic column 200 to be vibrated to chromatographic column 20, and vibrating member 110 can phase
Chromatographic column 200 is moved up and down.
Above-mentioned dress column device 100 contacts with the lateral wall of chromatographic column 200 outside to chromatographic column 200 due to vibrating member 110
Wall is vibrated so that the filler of chromatographic column 200 was not only closely knit but also uniform, and since vibrating member 110 can be with respect to chromatographic column about 200
Mobile, the column bed for realizing chromatographic column 200 was not only closely knit but also uniform.Above-mentioned dress column device 100, stationary phase filling packed uniform, column
Bed is stablized, so as to which with higher separative efficiency and preferable experimental repeatability, the dry column especially suitable for chromatographic column 200 fills column
Method filler.
Dress column device 100 includes multiple vibrating members 110 in one of the embodiments, and multiple vibrating member 110 is chromatographing
The sustained height upper edge chromatographic column 200 of column 200 is circumferential to be uniformly arranged.Therefore, the filler that can further promote chromatographic column 200 is closely knit
Degree and the uniformity.In the present embodiment, vibrating member 110 is three.
It is appreciated that vibrating member 110 directly can be contacted uniformly for annular with the lateral wall of chromatographic column 200, make chromatography
The filler of column 200 was not only closely knit but also uniform.
Dress column device 100 further includes first support 120 in one of the embodiments, and vibrating member 110 is movably disposed in
In first support 120, so as to make vibrating member 110 that can be moved up and down with respect to chromatographic column 200.Particularly, first support 120, which is equipped with, rises
Falling unit 121, lifting gear 121 is movably arranged at first support 120, and is fixedly connected with vibrating member 110, lifting gear
121 can drive vibrating member 110 to be moved up and down with respect to chromatographic column 200.
It is appreciated that vibrating member 110 can be equipped with handheld terminal, the handheld terminal is held, makes vibrating member 110 can be with respect to chromatographic column
200 move up and down, the so convenient application the narrow and small place or small test situations such as.
Specifically, vibrating member 110 is the device that can provide vibration source.More specifically, in the present embodiment, vibrating member 110
For vibrator.Specifically, in the present embodiment, vibrating member 110 is dither.
With reference to Fig. 2, particularly, dress column device 100 further includes regulating part 130, and regulating part 130 is set on two neighboring vibrating member
Between 110, regulating part 130 makes the close trend of 110 oriented chromatographic column of vibrating member, so as to adjust vibrating member 110 and chromatographic column 200
Lateral wall between active force, when filling column vibrating member 110 can so contacted with the lateral wall of chromatographic column 200 closer,
Vibrating member 110 is more effective to the vibration of chromatographic column 200, further promotes the density of filler.Specifically, regulating part 130 is bullet
Property part.More specifically, regulating part 130 is spring.
Dress column device 100 further includes second support 140 in one of the embodiments, and vibrating member 110 is arranged on second
On frame 140, and vibrating member 110 is connect by second support 140 with first support 120,110 phase of second support 140 and vibrating member
Chromatographic column 200 is synchronized and is moved up and down.Specifically, in the present embodiment, second support 140 is annular ring.
Particularly, with second support 140 on the sustained height of chromatographic column 200, vibrating member 110 is located at vibrating member 110
Between second support 140 and chromatographic column 200.
In a wherein embodiment, dress column device 100 further includes adjustment portion 111 and fixing piece 112, and adjustment portion 111 is fixed
Vibrating member 110 is connected to, and is movably attached to fixing piece 112, fixing piece 112 is fixedly connected on second support 140, passes through
The position of 111 opposed fixed member 112 of adjustment portion is adjusted, the distance between vibrating member 110 and second support 140 is adjusted, so as to
Make multiple vibrating members 110 different from the distance at 200 center of chromatographic column so that dress column device 100 is adapted in different-diameter range
Chromatographic column 200, be particularly suitable for the filling of industry major diameter chromatographic column 200, solve soft material and beat uneven, effect not
Good, the problem of labor intensity is big.
Specifically, adjustabel part 111 is fixed link, and fixing piece 112 is fixed sleeving, and fixing piece 112 is sleeved on adjustabel part 111
On.
In a wherein embodiment, dress column device 100 further includes cushion pad 150, cushion pad 150 be set on vibrating member 110 with
To protect chromatographic column 200 between the lateral wall of chromatographic column 200.Specifically, cushion pad 150 is rubber pad.
With continued reference to Fig. 1, the dress column system 10 of an embodiment, including chromatographic column 200, filler conduit 300, vacuum means
400, third stent 500 and above-mentioned dress column device 100 are put, chromatographic column 200 is set on third stent 500, dress column device 100
Vibrating member 110 is contacted with the lateral wall of chromatographic column 200 to be vibrated to chromatographic column 20, and vibrating member 110 can be with respect to chromatographic column
200 move up and down, and one end of filler conduit 300 is connect with the upper end of chromatographic column 200, the other end is inserted into filler to be installed, chromatography
The lower end of column 200 is connect with vacuum extractor 400.
Above-mentioned dress column system 10, using above-mentioned dress column device 100, the column bed for realizing chromatographic column 200 was not only uniform but also close
Real, column bed is stablized, so as to have higher separative efficiency and preferable experimental repeatability, applied to organic synthesis, natural products
During waiting research process chromatography, the dry column especially suitable for chromatographic column 200 fills column method filler.In addition, due to vacuumizing
Device 400 is connect with chromatographic column 200, and filler is made to be entered in chromatographic column 200 from filler conduit 300, and the nothing for realizing filler is let out
Dress is failed to fill in, avoids and powdered stationary phase is poured into harm of the airborne dust generated during chromatographic column 200 to operating personnel.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Embodiment described above only expresses the several embodiments of the present invention, and description is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that those of ordinary skill in the art are come
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (6)
1. a kind of dress column device, which is characterized in that for the filler of chromatographic column, it is described dress column device include vibrating member, first
Frame and second support, the vibrating member is contacted with the lateral wall of the chromatographic column to be vibrated to the chromatographic column, described to shake
Moving part is arranged in the second support, and the vibrating member is connect by the second support with the first support, described to shake
On the sustained height of the chromatographic column, the vibrating member is located at the second support and described for moving part and the second support
Between chromatographic column, the second support and the relatively described chromatographic column of the vibrating member synchronize move up and down；
The dress column device further includes adjustment portion and fixing piece, and the adjustment portion is fixedly connected on the vibrating member, and moves
Ground is connected to the fixing piece, and the fixing piece is fixedly connected on the second support, by adjusting the adjustment portion with respect to institute
The position of fixing piece is stated, the distance between the vibrating member and second support is adjusted, so as to make multiple vibrating members and institute
The distance for stating chromatographic column center is different.
2. dress column device according to claim 1, which is characterized in that the dress column device includes multiple vibrating members,
Chromatographic column described in sustained height upper edge of multiple vibrating members in the chromatographic column is axially uniformly arranged.
3. dress column device according to claim 2, which is characterized in that the dress column device further includes regulating part, the tune
It saves part to be set between the two neighboring vibrating member, the regulating part makes the oriented chromatographic column of the vibrating member is close to become
Gesture, so as to adjust the active force between the vibrating member and the lateral wall of the chromatographic column.
4. dress column device according to claim 1, which is characterized in that the vibrating member is equipped with handheld terminal, holds the hand
Hold end, make the vibrating member can relatively described chromatographic column move up and down.
5. dress column device according to claim 1, which is characterized in that the dress column device further includes cushion pad, described slow
Punching pad is set between the vibrating member and the lateral wall of the chromatographic column.
6. a kind of dress column system, which is characterized in that will including chromatographic column, filler conduit, vacuum extractor, third stent and right
1~5 any one of them is asked to fill column device, the chromatographic column is set on the third stent, and the described of dress column device shakes
Moving part is contacted with the lateral wall of the chromatographic column to be vibrated to the chromatographic column, and the vibrating member can be with respect on chromatographic column
Lower movement, one end of the filler conduit is connect with the upper end of the chromatographic column, the other end is inserted into filler to be installed, the chromatography
The lower end of column is connect with the vacuum extractor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510245419.8A CN106267895B (en) | 2015-05-14 | 2015-05-14 | Fill column device and dress column system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510245419.8A CN106267895B (en) | 2015-05-14 | 2015-05-14 | Fill column device and dress column system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106267895A CN106267895A (en) | 2017-01-04 |
| CN106267895B true CN106267895B (en) | 2018-06-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510245419.8A Active CN106267895B (en) | 2015-05-14 | 2015-05-14 | Fill column device and dress column system |
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| CN (1) | CN106267895B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109939464A (en) * | 2019-03-26 | 2019-06-28 | 闽江学院 | Portable chromatographic column charging vibrator |
| CN115337672A (en) * | 2022-08-05 | 2022-11-15 | 藤蔬生物科技(嘉兴)有限公司 | Matrix chromatography device and application method thereof in preparation of flavonoid compound |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2476320Y (en) * | 2001-04-29 | 2002-02-13 | 丁志坚 | Device for filling flexible material into chromatography column |
| CN201692690U (en) * | 2010-04-23 | 2011-01-05 | 聊城万合工业制造有限公司 | Multi-dimensional oscillating mechanism for chromatographic column main body |
| CN203663497U (en) * | 2013-10-21 | 2014-06-25 | 苏州宝化炭黑有限公司 | Packing chromatographic column preparing device |
| CN103071313B (en) * | 2007-03-09 | 2016-03-23 | 通用电气健康护理生物科学股份公司 | For loading system and the method for chromatographic column |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030146159A1 (en) * | 2002-02-06 | 2003-08-07 | Guiochon Georges A. | Method and apparatus to pack high efficiency columns for chromatography |
-
2015
- 2015-05-14 CN CN201510245419.8A patent/CN106267895B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2476320Y (en) * | 2001-04-29 | 2002-02-13 | 丁志坚 | Device for filling flexible material into chromatography column |
| CN103071313B (en) * | 2007-03-09 | 2016-03-23 | 通用电气健康护理生物科学股份公司 | For loading system and the method for chromatographic column |
| CN201692690U (en) * | 2010-04-23 | 2011-01-05 | 聊城万合工业制造有限公司 | Multi-dimensional oscillating mechanism for chromatographic column main body |
| CN203663497U (en) * | 2013-10-21 | 2014-06-25 | 苏州宝化炭黑有限公司 | Packing chromatographic column preparing device |
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| Publication number | Publication date |
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| CN106267895A (en) | 2017-01-04 |
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