CN106267895A - Dress column device and dress column system - Google Patents
Dress column device and dress column system Download PDFInfo
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- CN106267895A CN106267895A CN201510245419.8A CN201510245419A CN106267895A CN 106267895 A CN106267895 A CN 106267895A CN 201510245419 A CN201510245419 A CN 201510245419A CN 106267895 A CN106267895 A CN 106267895A
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- chromatographic column
- vibrating member
- dress
- column
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Abstract
The present invention relates to a kind of dress column device, for the filler of chromatographic column, described dress column device includes that vibrating member, described vibrating member contact to vibrate described chromatographic column with the lateral wall of described chromatographic column, and described vibrating member can move up and down by chromatographic column relatively.Above-mentioned dress column device, vibrates chromatographic column owing to vibrating member contacts with the lateral wall of chromatographic column so that the filler of chromatographic column is the most closely knit but also uniformly, and owing to vibrating member can move up and down by chromatographic column relatively, it is achieved that the post bed of chromatographic column is the most closely knit but also uniform.Above-mentioned dress column device, fixing packed uniform, the post bed of filling mutually is stable, thus has higher separation efficiency and preferable experimental repeatability, is particularly well-suited to the dry post dress post method filler of chromatographic column.
Description
Technical field
The present invention relates to the device field of chromatographic column filling, particularly relate to a kind of dress column device and dress column system.
Background technology
Chromatography technology, also referred to as chromatographic separation technology, be the conventional thing of a kind of laboratory and commercial production
Matter is analyzed and separation means, is such as required for using chromatography skill in organic synthesis, Natural products research
Art.Chromatography technology uses chromatographic column to fill fixing phase, and mixture to be separated passes through fixing mutually with flowing
Phase, due to the mechanism of action that material fixing and to be separated is different, makes material to be separated according to different reservations
Time sequencing flows out chromatographic column, thus has reached the purpose separating with analyzing.
At present, what the dress post of chromatographic column was conventional has wet method dress post and dry column-packing two ways.Wherein, dry method
Dress post, for fixing phase without solvent dilution during dress post, is fixed and is passed through gravity in the way of pressed powder
In entrance chromatographic column, and the gravity of self or impressed pressure is utilized to ensure the density between fixing phase.But
It is that dry column-packing generally uses soft material to beat chromatographic column so that the post bed of chromatographic column is closely knit at filling process,
And due to the heterogeneity beaten, cause filling uneven and affect separating effect.
Summary of the invention
Based on this, it is necessary to provide the fixing of a kind of chromatographic column to load uniform dress column device and dress column system mutually.
A kind of dress column device, for the filler of chromatographic column, described dress column device includes vibrating member, described vibration
Part contacts to vibrate described chromatographic column with the lateral wall of described chromatographic column, and described vibrating member can be relative
Chromatographic column moves up and down.
Above-mentioned dress column device, vibrates chromatographic column owing to vibrating member contacts with the lateral wall of chromatographic column, makes
The filler obtaining chromatographic column is the most closely knit but also uniform, and owing to vibrating member can move up and down by chromatographic column relatively, it is achieved that
The post bed of chromatographic column is the most closely knit but also uniform.Above-mentioned dress column device, fixes and fills packed uniform, post bed mutually stably,
Thus there is higher separation efficiency and preferable experimental repeatability, it is particularly well-suited to the dry post dress post of chromatographic column
Method filler.
Wherein in an embodiment, described dress column device includes multiple described vibrating member, multiple described vibrations
Part is axially uniformly arranged along described chromatographic column on the sustained height of described chromatographic column.
Wherein in an embodiment, described dress column device also includes that regulating part, described regulating part are located at adjacent
Between two described vibrating members, described regulating part makes the trend that the oriented described chromatographic column of described vibrating member is close,
Thus regulate the active force between the lateral wall of described vibrating member and described chromatographic column.
Wherein in an embodiment, described dress column device also includes the first support, and described vibrating member may move
Be located on described first support, so that described vibrating member can move up and down by the most described chromatographic column.
Wherein in an embodiment, described dress column device also includes that the second support, described vibrating member are arranged on
On described second support, described vibrating member is connected with described first support by described second support, and described the
Two supports described chromatographic column relative with described vibrating member synchronizes to move up and down.
Wherein in an embodiment, described vibrating member is equal same at described chromatographic column with described second support
On height, described vibrating member is between described second support and described chromatographic column.
Wherein in an embodiment, described dress column device also includes regulation portion and fixture, described regulation portion
Being fixedly connected on described vibrating member, and be movably attached to described fixture, described fixture is fixing to be connected
In described second support, by regulating the position of the most described fixture in described regulation portion, shake described in scalable
Distance between moving part and the second support, so that multiple described vibrating member and the distance at described chromatographic column center
Different.
Wherein in an embodiment, described vibrating member is provided with handheld terminal, hand-held described handheld terminal, makes described
Vibrating member can move up and down by the most described chromatographic column.
Wherein in an embodiment, it is described that described dress column device also includes that cushion pad, described cushion pad are located at
Between the lateral wall of vibrating member and described chromatographic column.
A kind of dress column system, including chromatographic column, filler conduit, vacuum extractor, the 3rd support and above-mentioned
Filling column device, described chromatographic column is located on described 3rd support, the described vibrating member of described dress column device and institute
The lateral wall stating chromatographic column contacts to vibrate described chromatographic column, and described vibrating member can chromatographic column relatively
Moving up and down, one end of described filler conduit is connected with the upper end of described chromatographic column, the other end inserts to be installed
Filler, the lower end of described chromatographic column is connected with described vacuum extractor.
Accompanying drawing explanation
Fig. 1 is the structural representation of the dress column system of an embodiment；
Fig. 2 is the part-structure schematic diagram of the dress column device of the dress column system shown in Fig. 1.
Detailed description of the invention
For the ease of understanding the present invention, below with reference to relevant drawings, the present invention is described more fully.
Accompanying drawing gives the preferred embodiment of the present invention.But, the present invention can come in many different forms
Realize, however it is not limited to embodiment described herein.On the contrary, provide the purpose of these embodiments be make right
The understanding of the disclosure is more thorough comprehensively.
It should be noted that when element is referred to as " being fixed on " another element, and it can be directly at another
On individual element or element placed in the middle can also be there is.When an element is considered as " connection " another yuan
Part, it can be directly to another element or may be simultaneously present centering elements.Used herein
Term " vertical ", " level ", "left", "right" and similar statement simply to illustrate that mesh
's.
With reference to Fig. 1, the dress column device 100 of an embodiment, for the filler of chromatographic column 200, fill column device
100 include that vibrating member 110, vibrating member 110 contact to enter chromatographic column 20 with the lateral wall of chromatographic column 200
Row vibrates, and vibrating member 110 can move up and down by chromatographic column 200 relatively.
Above-mentioned dress column device 100, owing to the lateral wall of vibrating member 110 with chromatographic column 200 contacts chromatographic column
The lateral wall of 200 vibrates so that the filler of chromatographic column 200 is the most closely knit but also uniform, and due to vibrating member
110 can move up and down by chromatographic column 200 relatively, it is achieved that the post bed of chromatographic column 200 is the most closely knit but also uniform.Above-mentioned
Dress column device 100, fixing packed uniform, the post bed of filling mutually is stable, thus has higher separation efficiency and relatively
Good experimental repeatability, is particularly well-suited to the dry post dress post method filler of chromatographic column 200.
Wherein in an embodiment, dress column device 100 includes multiple vibrating member 110, the plurality of vibrating member
110 are uniformly arranged along chromatographic column 200 circumference on the sustained height of chromatographic column 200.Accordingly, it is capable to carry further
Rise filler degree of compaction and the uniformity of chromatographic column 200.In the present embodiment, vibrating member 110 is three.
It is appreciated that vibrating member 110 can be directly annular thus with chromatographic column 200 lateral wall uniform contact,
The filler making chromatographic column 200 is the most closely knit but also uniform.
Wherein in an embodiment, dress column device 100 also includes the first support 120, and vibrating member 110 can move
It is located on the first support 120, so that vibrating member 110 can move up and down by chromatographic column 200 relatively dynamicly.Special
Not, the first support 120 is provided with lowering or hoisting gear 121, and lowering or hoisting gear 121 is movably arranged at the first support
120, and fixing with vibrating member 110 be connected, lowering or hoisting gear 121 can drive the relative chromatographic column 200 of vibrating member 110
Move up and down.
It is appreciated that vibrating member 110 can be provided with handheld terminal, this handheld terminal hand-held, makes the vibrating member 110 can phase
Chromatographic column 200 is moved up and down, the most convenient application in the situation such as narrow and small place or small test.
Specifically, vibrating member 110 is the device being provided that vibration source.More specifically, in the present embodiment,
Vibrating member 110 is vibrator.Specifically, in the present embodiment, vibrating member 110 is dither.
With reference to Fig. 2, especially, dress column device 100 also includes that regulating part 130, regulating part 130 are located at adjacent
Between two vibrating members 110, regulating part 130 makes the trend that the oriented chromatographic column of vibrating member 110 is close, thus
Active force between regulation vibrating member 110 and the lateral wall of chromatographic column 200, so can make vibration when filling post
Part 110 contacts tightr with the lateral wall of chromatographic column 200, and vibrating member 110 is to the vibration of chromatographic column 200 more
Effectively, the density of filler is promoted further.Specifically, regulating part 130 is elastic component.More specifically,
Regulating part 130 is spring.
Wherein in an embodiment, dress column device 100 also includes the second support 140, and vibrating member 110 is arranged
On the second support 140, and vibrating member 110 is connected with the first support 120 by the second support 140, the
Two support 140 chromatographic columns 200 relative with vibrating member 110 synchronize to move up and down.Specifically, at the present embodiment
In, the second support 140 is annular ring.
Especially, vibrating member 110 and the second support 140, all on the sustained height of chromatographic column 200, vibrate
Part 110 is between the second support 140 and chromatographic column 200.
Wherein in an embodiment, dress column device 100 also includes regulation portion 111 and fixture 112, regulation portion
111 are fixedly connected on vibrating member 110, and are movably attached to fixture 112, and fixture 112 is fixing even
It is connected to the second support 140, by the position of regulation regulation portion 111 opposed fixed member 112, scalable vibrating member
110 and second distances between support 140 so that multiple vibrating member 110 and chromatographic column 200 center away from
From difference so that dress column device 100 adapts to the chromatographic column 200 in different-diameter scope, is particularly suitable for industry
The filling of major diameter chromatographic column 200, solves soft material and beats uneven, poor effect, labor intensity
Big problem.
Specifically, adjustabel part 111 is fixing bar, and fixture 112 is fixed sleeving, and fixture 112 is enclosed within can
In tune portion 111.
Wherein in an embodiment, dress column device 100 also includes that vibration is located at by cushion pad 150, cushion pad 150
To protect chromatographic column 200 between the lateral wall of part 110 and chromatographic column 200.Specifically, cushion pad 150 is rubber
Rubber cushion.
With continued reference to Fig. 1, the dress column system 10 of an embodiment, including chromatographic column 200, filler conduit 300,
Vacuum extractor the 400, the 3rd support 500 and above-mentioned dress column device 100, chromatographic column 200 is located at the 3rd
On frame 500, the vibrating member 110 of dress column device 100 contacts with the lateral wall of chromatographic column 200 with to chromatographic column
20 vibrate, and vibrating member 110 can move up and down by chromatographic column 200 relatively, one end of filler conduit 300
Be connected with the upper end of chromatographic column 200, the other end inserts filler to be installed, the lower end of chromatographic column 200 with take out true
Empty device 400 connects.
Above-mentioned dress column system 10, uses above-mentioned dress column device 100, it is achieved that the post bed of chromatographic column 200 was both
The most closely knit, post bed is stablized, thus is had higher separation efficiency and preferable experimental repeatability, application
During the research process chromatography such as organic synthesis, natural product, it is particularly well-suited to chromatographic column 200
Dry post dress post method filler.Further, since vacuum extractor 400 is connected with chromatographic column 200, make filler from filling out
Material conduit 300 enters in chromatographic column 200, it is achieved that the No leakage of filler loads, it is to avoid by powder
Fixing pour chromatographic column 200 mutually into during the harm to operator of the airborne dust that produces.
Each technical characteristic of embodiment described above can combine arbitrarily, for making description succinct, the most right
The all possible combination of each technical characteristic in above-described embodiment is all described, but, if these skills
There is not contradiction in the combination of art feature, is all considered to be the scope that this specification is recorded.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed,
But can not therefore be construed as limiting the scope of the patent.It should be pointed out that, for this area
For those of ordinary skill, without departing from the inventive concept of the premise, it is also possible to make some deformation and change
Entering, these broadly fall into protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be with appended power
Profit requires to be as the criterion.
Claims (10)
1. a dress column device, it is characterised in that for the filler of chromatographic column, described dress column device includes shaking
Moving part, described vibrating member contacts to vibrate described chromatographic column with the lateral wall of described chromatographic column, and institute
State vibrating member can move up and down by chromatographic column relatively.
Dress column device the most according to claim 1, it is characterised in that described dress column device includes multiple
Described vibrating member, multiple described vibrating members are the most equal along described chromatographic column on the sustained height of described chromatographic column
Even setting.
Dress column device the most according to claim 2, it is characterised in that described dress column device also includes adjusting
Saving part, described regulating part is located between adjacent two described vibrating members, and described regulating part makes described vibrating member have
To the trend that described chromatographic column is close, thus regulate between the lateral wall of described vibrating member and described chromatographic column
Active force.
Dress column device the most according to claim 1, it is characterised in that described dress column device also includes
One support, described vibrating member is movably disposed on described first support, so that described vibrating member can be relative
Described chromatographic column moves up and down.
Dress column device the most according to claim 4, it is characterised in that described dress column device also includes
Two supports, described vibrating member is arranged on described second support, described vibrating member by described second support with
Described first support connects, and described second support described chromatographic column relative with described vibrating member synchronizes to move up and down.
Dress column device the most according to claim 5, it is characterised in that described vibrating member and described second
Support is all on the sustained height of described chromatographic column, and described vibrating member is positioned at described second support and described chromatography
Between post.
Dress column device the most according to claim 6, it is characterised in that described dress column device also includes adjusting
Joint portion and fixture, described regulation portion is fixedly connected on described vibrating member, and is movably attached to described solid
Locking member, described fixture is fixedly connected on described second support, the most described solid by regulating described regulation portion
The position of locking member, distance between vibrating member and the second support described in scalable, so that multiple described vibration
Part is different from the distance at described chromatographic column center.
Dress column device the most according to claim 1, it is characterised in that described vibrating member is provided with handheld terminal,
Hand-held described handheld terminal, makes described vibrating member to move up and down by the most described chromatographic column.
Dress column device the most according to claim 1, it is characterised in that described dress column device also includes delaying
Die head, described cushion pad is located between the lateral wall of described vibrating member and described chromatographic column.
10. one kind dress column system, it is characterised in that include chromatographic column, filler conduit, vacuum extractor,
Dress column device described in 3rd support and any one of claim 1～9, described chromatographic column is located at described 3rd
On frame, the described vibrating member of described dress column device contacts with the lateral wall of described chromatographic column with to described chromatographic column
Vibrating, and described vibrating member can move up and down by chromatographic column relatively, one end of described filler conduit is with described
The upper end of chromatographic column connects, the other end inserts filler to be installed, the lower end of described chromatographic column and described evacuation
Device connects.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510245419.8A CN106267895B (en) | 2015-05-14 | 2015-05-14 | Fill column device and dress column system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510245419.8A CN106267895B (en) | 2015-05-14 | 2015-05-14 | Fill column device and dress column system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106267895A true CN106267895A (en) | 2017-01-04 |
| CN106267895B CN106267895B (en) | 2018-06-26 |
Family
ID=57631051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510245419.8A Active CN106267895B (en) | 2015-05-14 | 2015-05-14 | Fill column device and dress column system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106267895B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109939464A (en) * | 2019-03-26 | 2019-06-28 | 闽江学院 | Portable chromatographic column charging vibrator |
| CN115337672A (en) * | 2022-08-05 | 2022-11-15 | 藤蔬生物科技(嘉兴)有限公司 | Matrix chromatography device and application method thereof in preparation of flavonoid compound |
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|---|---|---|---|---|
| CN2476320Y (en) * | 2001-04-29 | 2002-02-13 | 丁志坚 | Device for filling flexible material into chromatography column |
| US20030146159A1 (en) * | 2002-02-06 | 2003-08-07 | Guiochon Georges A. | Method and apparatus to pack high efficiency columns for chromatography |
| CN201692690U (en) * | 2010-04-23 | 2011-01-05 | 聊城万合工业制造有限公司 | Multi-dimensional oscillating mechanism for chromatographic column main body |
| CN203663497U (en) * | 2013-10-21 | 2014-06-25 | 苏州宝化炭黑有限公司 | Packing chromatographic column preparing device |
| CN103071313B (en) * | 2007-03-09 | 2016-03-23 | 通用电气健康护理生物科学股份公司 | For loading system and the method for chromatographic column |
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2015
- 2015-05-14 CN CN201510245419.8A patent/CN106267895B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2476320Y (en) * | 2001-04-29 | 2002-02-13 | 丁志坚 | Device for filling flexible material into chromatography column |
| US20030146159A1 (en) * | 2002-02-06 | 2003-08-07 | Guiochon Georges A. | Method and apparatus to pack high efficiency columns for chromatography |
| CN103071313B (en) * | 2007-03-09 | 2016-03-23 | 通用电气健康护理生物科学股份公司 | For loading system and the method for chromatographic column |
| CN201692690U (en) * | 2010-04-23 | 2011-01-05 | 聊城万合工业制造有限公司 | Multi-dimensional oscillating mechanism for chromatographic column main body |
| CN203663497U (en) * | 2013-10-21 | 2014-06-25 | 苏州宝化炭黑有限公司 | Packing chromatographic column preparing device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109939464A (en) * | 2019-03-26 | 2019-06-28 | 闽江学院 | Portable chromatographic column charging vibrator |
| CN115337672A (en) * | 2022-08-05 | 2022-11-15 | 藤蔬生物科技(嘉兴)有限公司 | Matrix chromatography device and application method thereof in preparation of flavonoid compound |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106267895B (en) | 2018-06-26 |
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