CN106267397A - 毛绒线式生物反应器人工肝系统 - Google Patents
毛绒线式生物反应器人工肝系统 Download PDFInfo
- Publication number
- CN106267397A CN106267397A CN201610613094.9A CN201610613094A CN106267397A CN 106267397 A CN106267397 A CN 106267397A CN 201610613094 A CN201610613094 A CN 201610613094A CN 106267397 A CN106267397 A CN 106267397A
- Authority
- CN
- China
- Prior art keywords
- reactor
- blood
- bioartificial liver
- wire type
- liver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004185 liver Anatomy 0.000 title claims abstract description 117
- 210000004369 blood Anatomy 0.000 claims abstract description 55
- 239000008280 blood Substances 0.000 claims abstract description 55
- 239000012510 hollow fiber Substances 0.000 claims abstract description 42
- 210000002381 plasma Anatomy 0.000 claims abstract description 42
- 210000003494 hepatocyte Anatomy 0.000 claims abstract description 39
- 238000009940 knitting Methods 0.000 claims abstract description 35
- 210000002268 wool Anatomy 0.000 claims abstract description 35
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 17
- 238000011084 recovery Methods 0.000 claims abstract description 12
- 210000003677 hemocyte Anatomy 0.000 claims abstract description 8
- 229940000351 hemocyte Drugs 0.000 claims abstract description 8
- 238000012544 monitoring process Methods 0.000 claims description 23
- 238000010438 heat treatment Methods 0.000 claims description 15
- 238000012806 monitoring device Methods 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 14
- 230000001413 cellular effect Effects 0.000 claims description 11
- 210000004209 hair Anatomy 0.000 claims description 10
- 229920005749 polyurethane resin Polymers 0.000 claims description 8
- 238000011144 upstream manufacturing Methods 0.000 claims description 8
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 7
- 229960002897 heparin Drugs 0.000 claims description 7
- 229920000669 heparin Polymers 0.000 claims description 7
- 235000015097 nutrients Nutrition 0.000 claims description 7
- 235000016709 nutrition Nutrition 0.000 claims description 7
- 230000003134 recirculating effect Effects 0.000 claims description 7
- 239000002002 slurry Substances 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 6
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- 230000000694 effects Effects 0.000 description 7
- 206010019663 Hepatic failure Diseases 0.000 description 5
- 208000007903 liver failure Diseases 0.000 description 5
- 231100000835 liver failure Toxicity 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
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- 238000000034 method Methods 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 239000008358 core component Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 230000031142 liver development Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000006068 polycondensation reaction Methods 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
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- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
- A61M1/166—Heating
- A61M1/1664—Heating with temperature control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/362—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/14—Scaffolds; Matrices
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- External Artificial Organs (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610613094.9A CN106267397B (zh) | 2016-07-29 | 2016-07-29 | 毛绒线式生物反应器人工肝系统 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610613094.9A CN106267397B (zh) | 2016-07-29 | 2016-07-29 | 毛绒线式生物反应器人工肝系统 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106267397A true CN106267397A (zh) | 2017-01-04 |
CN106267397B CN106267397B (zh) | 2019-02-05 |
Family
ID=57663402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610613094.9A Active CN106267397B (zh) | 2016-07-29 | 2016-07-29 | 毛绒线式生物反应器人工肝系统 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106267397B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019148611A1 (zh) * | 2018-02-01 | 2019-08-08 | 南方医科大学珠江医院 | 组合型生物人工肝支持系统 |
CN113082337A (zh) * | 2021-02-23 | 2021-07-09 | 广东乾晖生物科技有限公司 | 基于胎盘间充质干细胞生物反应器的生物人工肝支持系统 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5043260A (en) * | 1987-11-02 | 1991-08-27 | Rhode Island Hospital | Perfusion device with hepatocytes |
US20050209687A1 (en) * | 2002-02-19 | 2005-09-22 | Bioartis, Inc. | Artificial vessel scaffold and artifical organs therefrom |
CN2803310Y (zh) * | 2004-12-24 | 2006-08-09 | 浙江大学 | 人工肝用生物反应器 |
CN101081182A (zh) * | 2007-07-05 | 2007-12-05 | 南京大学医学院附属鼓楼医院 | 新型生物人工肝细胞反应器 |
CN201180139Y (zh) * | 2007-04-24 | 2009-01-14 | 博傲西腾医疗科技(上海)有限公司 | 一种保持有效层间距的人工肝反应器 |
CN203802865U (zh) * | 2014-04-27 | 2014-09-03 | 周平 | 充填复合材料和微载体的生物人工肝反应器 |
CN205386253U (zh) * | 2015-12-30 | 2016-07-20 | 武汉仝干生物科技有限公司 | 生物人工肝在线监测与恒温加热一体系统 |
-
2016
- 2016-07-29 CN CN201610613094.9A patent/CN106267397B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5043260A (en) * | 1987-11-02 | 1991-08-27 | Rhode Island Hospital | Perfusion device with hepatocytes |
US20050209687A1 (en) * | 2002-02-19 | 2005-09-22 | Bioartis, Inc. | Artificial vessel scaffold and artifical organs therefrom |
CN2803310Y (zh) * | 2004-12-24 | 2006-08-09 | 浙江大学 | 人工肝用生物反应器 |
CN201180139Y (zh) * | 2007-04-24 | 2009-01-14 | 博傲西腾医疗科技(上海)有限公司 | 一种保持有效层间距的人工肝反应器 |
CN101081182A (zh) * | 2007-07-05 | 2007-12-05 | 南京大学医学院附属鼓楼医院 | 新型生物人工肝细胞反应器 |
CN203802865U (zh) * | 2014-04-27 | 2014-09-03 | 周平 | 充填复合材料和微载体的生物人工肝反应器 |
CN205386253U (zh) * | 2015-12-30 | 2016-07-20 | 武汉仝干生物科技有限公司 | 生物人工肝在线监测与恒温加热一体系统 |
Non-Patent Citations (1)
Title |
---|
陈观文等: "《膜技术新进展与工程应用》", 31 December 2013 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019148611A1 (zh) * | 2018-02-01 | 2019-08-08 | 南方医科大学珠江医院 | 组合型生物人工肝支持系统 |
US11911552B2 (en) | 2018-02-01 | 2024-02-27 | Southern Medical University Zhujiang Hospital | Combined bio-artificial liver support system |
CN113082337A (zh) * | 2021-02-23 | 2021-07-09 | 广东乾晖生物科技有限公司 | 基于胎盘间充质干细胞生物反应器的生物人工肝支持系统 |
Also Published As
Publication number | Publication date |
---|---|
CN106267397B (zh) | 2019-02-05 |
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Denomination of invention: Plush wire bioreactor artificial liver system Effective date of registration: 20220629 Granted publication date: 20190205 Pledgee: Pudong Shanghai Development Bank Limited by Share Ltd. Wuhan branch Pledgor: WUHAN TOGO MEDITECH Co.,Ltd. Registration number: Y2022420000204 |
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CP03 | Change of name, title or address |
Address after: 4th floor, podium building, Gongtou Building, No. 433-505 Chunhui Road, Lingxi Town, Cangnan County, Wenzhou City, Zhejiang Province, 325000 Patentee after: Zhejiang Tonggan Medical Technology Co.,Ltd. Country or region after: China Address before: No. 818, Gaoxin Avenue, Donghu high tech Development Zone, Wuhan, Hubei 430206 Patentee before: WUHAN TOGO MEDITECH Co.,Ltd. Country or region before: China |