CN106266359A - A kind of extract for preparing invigorating the lung and benefiting vital QI preparation - Google Patents
A kind of extract for preparing invigorating the lung and benefiting vital QI preparation Download PDFInfo
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- CN106266359A CN106266359A CN201510259336.4A CN201510259336A CN106266359A CN 106266359 A CN106266359 A CN 106266359A CN 201510259336 A CN201510259336 A CN 201510259336A CN 106266359 A CN106266359 A CN 106266359A
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Abstract
A kind of extract for preparing invigorating the lung and benefiting vital QI tablets/capsules/granule/pill of disclosure of the invention, this extract is obtained by improved extraction process, extraction process after improvement improves the content of the effective ingredient such as unit formulation Ephedrine, and residue on ignition has substantially reduction.
Description
Technical field:
The invention belongs to field of medicaments, relate to the Chinese crude drug of the diffusing-freeing lung rectifying medicinal preparation of a kind of improvement
Extraction process.
Background technology: invigorating the lung and benefiting vital QI ball, relieving exterior syndrome and dispelling cold, lung qi dispersing antitussive.For caused by anemofrigid cold
Cough, fever with chills, watery nasal discharge of having a stuffy nose, have a headache lossless, limb aching pain.Prescription consists of: old
Skin 96g, Rhizoma Pinelliae (processed) 72g, Poria 96g, Fructus Aurantii (parched) 96g, Radix Scutellariae 96g, purple
Folium Perillae 144g, Radix Peucedani 96g, Radix Platycodonis 96g, Semen Armeniacae Amarum 72g, Herba Ephedrae 96g, Radix Glycyrrhizae 72g,
Above ten simply, are ground into fine powder, sieve, mixing, add the city water honey of appropriate water with refined honey
Ball.Along with part medical material is separately carried by the development technical staff of Chinese medicine extraction technology
Take, and carry out the design of extraction scheme according to the character of its medicinal ingredient, and be made for granule,
Tablet and capsule, presently disclosed technique is as follows:
[prescription] Folium Perillae 180g Radix Peucedani 120g Radix Platycodonis 120g Semen Armeniacae Amarum 90g
Herba Ephedrae 120g Radix Glycyrrhizae 90g Pericarpium Citri Reticulatae 120g Rhizoma Pinelliae (processed) 90 Poria 120g trifoliate orange
Shell (stir-fry) 120g Radix Scutellariae 120g
Make 1000 slices/
More than [preparation method], ten simply, takes Rhizoma Pinelliae Preparata and Fructus Aurantii 48g pulverizes jointly as fine powder；
Folium Perillae, Pericarpium Citri Reticulatae extraction by steam distillation volatile oil, separates volatile oil → 2, standby；
Medicinal liquid filters, and medicinal residues add water decoction 2 hours, filters, and merging filtrate, water cooking liquid is standby；
Semen Armeniacae Amarum squeezing is deoiled, and takes its slag and remaining Fructus Aurantii, extracts two with 85% alcohol heating reflux
Secondary, each 2 hours, merge ethanol extract, filter, filtrate recycling ethanol is also concentrated into phase
It is the thick paste of 1.36 (50 DEG C) to density, standby；The Six-element boilings two such as remaining Radix Peucedani
Secondary, each 2 hours, collecting decoction, filter, decocting liquid is standby；Merge above-mentioned decocting liquid,
Be evaporated to the thick paste of relative density 1.34～1.38 (50 DEG C), add above-mentioned Rhizoma Pinelliae Preparata,
Fructus Aurantii fine powder and Semen Armeniacae Amarum, Fructus Aurantii thick paste, mixing, make granule, be dried, (1) sprays into
State volatile oil, mixing, tabletting, sugar coating or film-coat；(2) capsule is filled；(3) subpackage
Become granule.At present domestic production Tongxuanlifei tablet, capsule, granule manufacturer universal
Above-mentioned technique is used to produce.
My unit technical staff is when studying the production technology of Tongxuanlifei sheet, through anti-
Multiple test, has invented the extraction process of a kind of improvement, and this extraction process is maintaining former technique base
In the case of this is the most constant, by regulation pH value, increase the means such as time soaked and make unit
Content of Ephedrine With in preparation has had and has significantly promoted, and average increase rate is more than 70%.
Summary of the invention:
Presently disclosed technique is as follows:
[prescription] Folium Perillae 180g Radix Peucedani 120g Radix Platycodonis 120g
Semen Armeniacae Amarum 90g Herba Ephedrae 120g Radix Glycyrrhizae 90g Pericarpium Citri Reticulatae 120g
Rhizoma Pinelliae (processed) 90g Poria 120g Fructus Aurantii (parched) 120g Radix Scutellariae 120g
Make 1000 slices/
(1) more than, ten simply, takes Rhizoma Pinelliae Preparata and Fructus Aurantii 48g pulverizes jointly as fine powder；Folium Perillae,
Pericarpium Citri Reticulatae extraction by steam distillation volatile oil, separates volatile oil, standby；
(2) medicinal liquid filters, and medicinal residues add water decoction 2 hours, filters, merging filtrate, decocting in water
Liquid is standby；Semen Armeniacae Amarum squeezing is deoiled, and takes its slag and remaining Fructus Aurantii, with 85% second
Alcohol heating and refluxing extraction secondary, each 2 hours, merges ethanol extract, filters,
Filtrate recycling ethanol is also concentrated into the thick paste that relative density is 1.36 (50 DEG C), standby
With；
(3) the Six-element boiling secondary such as remaining Radix Peucedani, each 2 hours, collecting decoction, filter
Crossing, decocting liquid is standby；Merge above-mentioned decocting liquid, be evaporated to relative density
The thick paste of 1.34～1.38 (50 DEG C), add above-mentioned Rhizoma Pinelliae Preparata, Fructus Aurantii fine powder and
Semen Armeniacae Amarum, Fructus Aurantii thick paste, mixing, make granule, be dried, spray into above-mentioned volatilization
Oil, mixing；
(4) (1) tabletting, sugar coating or film-coat；(2) capsule is filled；(3) it is distributed into
Granule.
Main the improving in (3rd) above-mentioned step of the present invention, the complete process after improvement is as follows:
[prescription] Folium Perillae 180g Radix Peucedani 120g Radix Platycodonis 120 is bitter
Semen Armeniacae Amarum 90g Herba Ephedrae 120g Radix Glycyrrhizae 90g Pericarpium Citri Reticulatae 120g Rhizoma Pinelliae (processed)
90g Poria 120g Fructus Aurantii (parched) 120g Radix Scutellariae 120g
Make 1000 slices/
(1) more than, ten simply, takes Rhizoma Pinelliae Preparata and Fructus Aurantii 48g pulverizes jointly as fine powder；Folium Perillae,
Pericarpium Citri Reticulatae extraction by steam distillation volatile oil, separates volatile oil, standby；
(2) medicinal liquid filters, and medicinal residues add water decoction 2 hours, filters, merging filtrate, decocting in water
Liquid is standby；Semen Armeniacae Amarum squeezing is deoiled, and takes its slag and remaining Fructus Aurantii, with 85% second
Alcohol heating and refluxing extraction secondary, each 2 hours, merges ethanol extract, filters,
Filtrate recycling ethanol is also concentrated into the thick paste that relative density is 1.36 (50 DEG C), standby
With；
(3) Six-element such as remaining Radix Peucedani adds the water of medical material 4-6 times amount, and regulation pH value, to 9-10, soaks
4-6 hour, reflux, extract, 2-3 hour, filter and separate extracting solution；Medicinal residues continuously add
The water of 4-6 times amount, regulation pH value, to 9-10, soaks 4-6 hour, reflux, extract, 2-3
Hour, cross leaching extracting solution；Merging the decocting liquid of (1) and (2), regulation pH value is extremely
7-9, is evaporated to relative density 1.34～1.38 at 50 ± 5 DEG C.Add above-mentioned system
The Rhizoma Pinelliae, Fructus Aurantii fine powder and Semen Armeniacae Amarum, Fructus Aurantii thick paste, mixing, make granule, be dried,
Spray into above-mentioned volatile oil, mixing；
(4) 1. tabletting, sugar coating or film-coat；2. capsule is filled；3. granule it is distributed into.
By the improvement of (3rd) step process makes the content of unit formulation Ephedrine improve
More than 70%, and residue on ignition had a significant reduction.
It is known that due to the change of extraction process, the change of parameter, extract can be caused
Material base change, thus cause effective ingredient in extract to improve or reduce,
The present invention is by changing physicochemical property and the parameter of extraction process of solvent so that effective ingredient
Content gets a promotion, and the impurity containing inorganic salt, heavy metal is reduced.
Use improve after extraction process, produce three batches of tablets, lot number be respectively 0601A,
0602A, 0603A, use traditional handicraft same size to carry out confirmatory production three batches, and lot number divides
Not Wei 0601B, 0602B, 0603B, carry out the assay of the ephedrine of unit formulation and vehement
The mensuration of bright residue, the content of the ephedrine in the preparation that the extraction process after employing improvement is made
It is significantly higher than conventionally produced preparation, and residue on ignition is substantially less than traditional processing technology life
The preparation produced.
Specific embodiment:
Embodiment 1: the preparation of the invigorating the lung and benefiting vital QI tablet after improvement
[prescription] Folium Perillae 180g, Radix Peucedani 120g, Radix Platycodonis 120g, Semen Armeniacae Amarum 90g, fiber crops
Yellow 120g, Radix Glycyrrhizae 90g, Pericarpium Citri Reticulatae 120g, Rhizoma Pinelliae (processed) 90g, Poria 120g, Fructus Aurantii (parched)
120g, Radix Scutellariae 120g
Make 1000
(1) more than, ten simply, takes Rhizoma Pinelliae Preparata and Fructus Aurantii 48g pulverizes jointly as fine powder；Folium Perillae,
Pericarpium Citri Reticulatae extraction by steam distillation volatile oil, separates volatile oil, standby；
(2) medicinal liquid filters, and medicinal residues add water decoction 2 hours, filters, merging filtrate, water cooking liquid
Standby；Semen Armeniacae Amarum squeezing is deoiled, and takes its slag and remaining Fructus Aurantii, with 85% alcohol heating reflux
Extracting secondary, each 2 hours, merge ethanol extract, filter, filtrate recycling ethanol is the denseest
It is reduced to the thick paste that relative density is 1.36 (50 DEG C), standby；
(3) Six-element such as remaining Radix Peucedani adds the water of medical material 4-6 times amount, regulation pH value to 9-10, leaching
Steep 4-6 hour, reflux, extract, 2-3 hour, filter and separate extracting solution；Medicinal residues continuously add
The water of 4-6 times amount, regulation pH value, to 9-10, soaks 4-6 hour, and reflux, extract, 2-3 is little
Time, cross leaching extracting solution；Merge (1) and (2) decocting liquid, regulate pH value to 7-9,
It is evaporated to relative density 1.34～1.38 at 50 ± 5 DEG C.Add above-mentioned Rhizoma Pinelliae Preparata, trifoliate orange
Shell fine powder and Semen Armeniacae Amarum, Fructus Aurantii thick paste, mixing, make granule, be dried, spray into above-mentioned volatilization
Oil, mixing；
(4) tabletting makes 1000.
Producing 3 batches continuously, lot number is respectively as follows: 0601A, 0602A, 0603A.
Embodiment 2: the preparation of the invigorating the lung and benefiting vital QI sheet of the same scale of employing traditional handicraft:
[prescription] Folium Perillae 180g, Radix Peucedani 120g, Radix Platycodonis 120g, Semen Armeniacae Amarum 90g,
Herba Ephedrae 120g, Radix Glycyrrhizae 90g, Pericarpium Citri Reticulatae 120g, Rhizoma Pinelliae (processed) 90g, Poria 120g, trifoliate orange
Shell (stir-fry) 120g, Radix Scutellariae 120g
Make 1000
(1) more than, ten simply, takes Rhizoma Pinelliae Preparata and Fructus Aurantii 48g pulverizes jointly as fine powder；Folium Perillae
Leaf, Pericarpium Citri Reticulatae extraction by steam distillation volatile oil, separates volatile oil, standby；
(2) medicinal liquid filters, and medicinal residues add water decoction 2 hours, filters, merging filtrate, water
Boil liquid standby；Semen Armeniacae Amarum squeezing is deoiled, and takes its slag and remaining Fructus Aurantii, with 85% ethanol heating
Reflux, extract, secondary, each 2 hours, merges ethanol extract, filters, filtrate recycling ethanol
And it is concentrated into the thick paste that relative density is 1.36 (50 DEG C), standby；
(3) the Six-element boiling secondary such as remaining Radix Peucedani, each 2 hours, collecting decoction,
Filtering, decocting liquid is standby；Merge above-mentioned decocting liquid, be evaporated to relative density 1.34～
The thick paste of 1.38 (50 DEG C), adds above-mentioned Rhizoma Pinelliae Preparata, Fructus Aurantii fine powder and Semen Armeniacae Amarum, Fructus Aurantii thick
Cream, mixing, make granule, be dried, spray into above-mentioned volatile oil, mixing；
(4) tabletting, produces three batches continuously, and lot number is respectively as follows: 0601B, 0602B, 0603B.
The content of invigorating the lung and benefiting vital QI sheet Ephedrine prepared by 3: two kinds of various processes of embodiment
The comparison of measurement result:
(1), the content assaying method of ephedrine: taking 20, accurately weighed, add water 20ml
Dissolve, put in separatory funnel, with Petroleum ether extraction 4 times (20,15,15,15ml), water
Layer with n-butanol extraction 4 times (25,20,20,20ml), united extraction liquid, use anhydrous sulfur
After acid sodium dehydration, decompression removes n-butyl alcohol, and residue adds methanol and dissolves and be settled to 2ml, as
Need testing solution.Separately take astragaloside reference substance, add methanol and make every 1ml solution containing 1mg,
As reference substance solution.Test according to thin layer chromatography (annex VI B), draw need testing solution
5 μ ls each with reference substance solution, cross point is on same silica gel g thin-layer plate respectively, with chloroform
-methanol-water (30: 10: 1) is developing solvent, launches, and takes out, dries, and spray is with 10%
Ethanol solution of sulfuric acid, 105 DEG C dry about 5 minutes clear to spot development, take out, at thin layer
Covering an equal amount of glass plate on plate, surrounding immobilization with adhesive tape, according to thin layer chromatography (annex
VI B thin layer chromatography scanning) it is scanned, wavelength X ＜ [s] ＞=530nm, measure test sample and inhale
Receipts degree integrated value and reference substance trap integrated value, calculate the content of every contained ephedrine, take
The meansigma methods of 20.
The assay method of residue on ignition: take test sample 20, puts in the crucible of ignition to constant weight,
Accurately weighed, the most blazing to complete carbonization, let cool；Add sulphuric acid 0.5～1ml to make to moisten, low
Temperature is heated to after sulfuric acid vapor eliminates, at 700～800 DEG C of ignition to constant weight, calculating meansigma methods.
(3), measurement result is as in the table below:
| Lot number | The content (mg) of ephedrine | Residue on ignition (mg) |
| 0601A | 0.99 | 0.11 |
| 0601B | 0.61 | 0.21 |
| 0602A | 1.10 | 0.14 |
| 0602B | 0.68 | 0.35 |
| 0603A | 1.15 | 0.10 |
| 0603B | 0.62 | 0.33 |
Invigorating the lung and benefiting vital QI sheet Ephedrine prepared by the extraction process after result display employing improvement
The invigorating the lung and benefiting vital QI sheet that content is prepared obviously higher than traditional handicraft, residue on ignition is substantially less than and passes
The tablet that system technique produces.
Embodiment 4: the preparation of the invigorating the lung and benefiting vital QI capsule after improvement
[prescription] Folium Perillae 180g, Radix Peucedani 120g, Radix Platycodonis 120g, Semen Armeniacae Amarum 90g
, Herba Ephedrae 120g, Radix Glycyrrhizae 90g, Pericarpium Citri Reticulatae 120g, Rhizoma Pinelliae (processed) 90g, Poria 120g,
Fructus Aurantii (parched) 120g, Radix Scutellariae 120g
Make 1000 seed lac capsules
(1) more than, ten simply, takes Rhizoma Pinelliae Preparata and Fructus Aurantii 48g pulverizes jointly as fine powder；Purple
Folium Perillae, Pericarpium Citri Reticulatae extraction by steam distillation volatile oil, separates volatile oil, standby；
(2) medicinal liquid filters, and medicinal residues add water decoction 2 hours, filters, merging filtrate,
Water cooking liquid is standby；Semen Armeniacae Amarum squeezing is deoiled, and takes its slag and remaining Fructus Aurantii, adds with 85% ethanol
Circumfluence distillation secondary, each 2 hours, merges ethanol extract, filters, and filtrate is reclaimed
Ethanol is also concentrated into the thick paste that relative density is 1.36 (50 DEG C), standby；
(3) Six-element such as remaining Radix Peucedani adds the water of medical material 4-6 times amount, and regulation pH value is extremely
9-10, soaks 4-6 hour, reflux, extract, 2-3 hour, filters and separates extracting solution；Medicinal residues
Continuously adding the water of 4-6 times amount, regulation pH value, to 9-10, soaks 4-6 hour, and backflow carries
Take 2-3 hour, cross leaching extracting solution；Merge the decocting liquid of (1) and (2), regulate PH
Value, to 7-9, is evaporated to relative density 1.34～1.38 at 50 ± 5 DEG C.Add above-mentioned
Rhizoma Pinelliae Preparata, Fructus Aurantii fine powder and Semen Armeniacae Amarum, Fructus Aurantii thick paste, mixing, make granule, be dried,
Spray into above-mentioned volatile oil, mixing；
(4) fill to capsule 1000.
Claims (2)
1. for preparing the extract of invigorating the lung and benefiting vital QI tablets/capsules/pellets/granules, this extract by with
Lower step is extracted and is obtained:
(1) Radix Peucedani 120 parts ± 20%, Radix Platycodonis 120 parts ± 20%, Herba Ephedrae 120 parts ± 20%, Radix Glycyrrhizae
90 parts ± 20%, Poria 120 parts ± 20%, Radix Scutellariae 120 parts ± 20%, add medical material 4-6
The water of times amount, regulation pH value, to 9-10, soaks 4-6 hour, reflux, extract, 2-3
Hour, filter and separate extracting solution；
(2) medicinal residues continuously add the water of 4-6 times amount, and regulation pH value, to 9-10, soaks 4-6 hour,
Reflux, extract, 2-3 hour, crosses leaching extracting solution；
(3) merging the decocting liquid of (1) and (2), regulation pH value is to 7-9, at 50 ± 5 DEG C
It is evaporated to relative density 1.34～1.38.
2. tablets/capsules/granule/the pill of Tongxuanlifei prepared by extract described in employing claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510259336.4A CN106266359A (en) | 2015-05-19 | 2015-05-19 | A kind of extract for preparing invigorating the lung and benefiting vital QI preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510259336.4A CN106266359A (en) | 2015-05-19 | 2015-05-19 | A kind of extract for preparing invigorating the lung and benefiting vital QI preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106266359A true CN106266359A (en) | 2017-01-04 |
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ID=57633395
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510259336.4A Pending CN106266359A (en) | 2015-05-19 | 2015-05-19 | A kind of extract for preparing invigorating the lung and benefiting vital QI preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106266359A (en) |
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2015
- 2015-05-19 CN CN201510259336.4A patent/CN106266359A/en active Pending
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170104 |
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| WD01 | Invention patent application deemed withdrawn after publication |