CN106266173A - A kind of body-building weight-reducing compositions and preparation method and application - Google Patents

A kind of body-building weight-reducing compositions and preparation method and application Download PDF

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CN106266173A
CN106266173A CN201610817511.1A CN201610817511A CN106266173A CN 106266173 A CN106266173 A CN 106266173A CN 201610817511 A CN201610817511 A CN 201610817511A CN 106266173 A CN106266173 A CN 106266173A
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extract
water
fructus broussonetiae
building weight
violent
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周建伟
赵晨子
商银行
单姗
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Xuchang University
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Xuchang University
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    • AHUMAN NECESSITIES
    • A41WEARING APPAREL
    • A41DOUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00Materials specially adapted for outerwear
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/56Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/37Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/55Liquid-liquid separation; Phase separation

Abstract

The invention discloses a kind of body-building weight-reducing compositions and preparation method and application, described compositions, according to mass percent, is made up of following components: mosquito leaf extract 2.3 2.8%, Fructus Broussonetiae extract 0.20 0.35%, Herba veronicae herb extract 1.2 1.5%, yellow violent dish root extract 0.60 0.75%, mineral oil 22 25%, Fructrs Hippophae seed oil 1.2 1.6%, cetyl lactate 6 7%, menthyl lactate 5 6%, vaseline 12 15%, guar gum 1.5 2.0%, water 40 46%.The present invention uses the compounding use of mosquito leaf extract, Fructus Broussonetiae extract, Herba veronicae herb extract and Huang Meng dish root extract these four component, each component is the most collaborative, skin care while supplementing multiple nutrient for skin, working substance can penetrate deep into skin, suppression Fat Accumulation, accelerate steatolysis, play the effect of body-building weight-reducing.

Description

A kind of body-building weight-reducing compositions and preparation method and application
Technical field
The present invention relates to body-building weight-reducing technical field, specifically one body-building weight-reducing compositions and preparation method thereof and answer With.
Background technology
Obesity refers to a certain degree of the most overweight blocked up with fat deposit, is body fat, especially triglyceride accumulation A kind of state too much caused.Due to food intake too much or the change of organism metabolism and cause body fat accumulation too much to be made Excess weight is become to increase and cause human pathology, physiological change or hide.The health that obesity is not general is too fat to move, but a kind of prestige The chronic disease of side of body human health, is one group of common, ancient metabolic syndrome.The sorting technique of obesity is a lot, generally It is divided into Simple Obesity, Secondary Obesity and drug induced obesity.Obesity evaluation criteria is as follows:
Mild Obesity: body weight (kg) > [height (cm)-100] × 0.9 × 1.2;
Central obesity: body weight (kg) > [height (cm)-100] × 0.9 × 1.4;
High obesity: body weight (kg) > [height (cm)-100] × 0.9 × 1.6.
Fat not only affect the attractive in appearance of body line, but also the health of direct harmful to human: 1, increase cardiovascular disease Danger;2, the function of digestive system is affected;3, the function of hormonal system is affected;4 increase the danger that cancer occurs;5, close Joint soft tissue easily damages;6, reproductive performance declines;7, the phenomenons such as mental maladjustment easily occur.
Along with the cognition of problem of obesity is got more and more by people, a lot of people carry out loss of weight by various body-building weight-reducing means, Thus the figure kept fit.Existing body-building weight-reducing means mainly have exercise, weight-reducing medicine, outer wiping weight-reducing for oral administration Product.Its China and foreign countries wipe weight-reducing product and are mostly artificial chemistry synthetic, though its curative effect is good, but life-time service penetrates into skin In skin, the organ functions such as endocrine dysfunction, the infringement heart, liver, kidney can be caused, cause chloasma, acne etc. to damage U.S.'s property skin Sick, in some instances it may even be possible to induction cancer.Currently also there is a minority traditional Chinese medicine capable of reducing weight slim product, but its poor effect.So research and development are with fat Pathology matches, effect is progressive and stablizes, do not harm health, be that the main double pure green pure to take stopgap measures is the most primary to effect a permanent cure State, can weight-reducing again can sports increase rhythm product be only trend of the times.
Summary of the invention
It is an object of the invention to provide body-building weight-reducing compositions that a kind of effect is good, have no side effect and preparation method thereof with Application.
For achieving the above object, the present invention provides following technical scheme:
A kind of body-building weight-reducing compositions, according to mass percent, is made up of following components: mosquito leaf extract 2.3- 2.8%, Fructus Broussonetiae extract 0.20-0.35%, Herba veronicae herb extract 1.2-1.5%, yellow violent dish root extract 0.60- 0.75%, mineral oil 22-25%, Fructrs Hippophae seed oil 1.2-1.6%, cetyl lactate 6-7%, menthyl lactate 5-6%, all Intellectual circle 12-15%, guar gum 1.5-2.0%, water 40-46%;
The preparation process of described mosquito leaf extract is: by mosquito leaves coarse pulverization, add the 5-6 times amount of its quality The ethanol water that volumetric concentration is 76-78% in soak after 2-3h, under the conditions of 45-48 DEG C, carry out ultrasonic extraction, super Acoustic power is 650-780W, and ultrasonic frequency is 20kHz, and extraction time is 1.5-2h, separates to obtain the first extracting solution and first Filtering residue;After being mixed homogeneously by the water of the first filtering residue with the 3-4 times amount of mosquito leaves quality, utilize the microwave that power is 360-380W Assisted extraction 3-5min, obtains the second extracting solution;First extracting solution and the second extracting solution are merged, filters, through being concentrated in vacuo to nothing Alcohol taste, obtains concentrated solution;By macroporous resin column on concentrated solution, successively with the water elution of 7-8 times of column volume, the body of 5-6 times of column volume Volume concentrations is the ethanol water eluting of 55-60%, and the volumetric concentration of 3-4 times of column volume is the ethanol aqueous wash of 88-92% De-, merge eluent, eluent is concentrated into the 1/3-1/4 of proper mass, dry, pulverize, cross 250-350 mesh sieve, obtain mosquito tree Leaf extract;
The preparation process of described Fructus Broussonetiae extract is: Fructus Broussonetiae is placed in super micron mill pulverizing 60- 80min, crosses 350-400 mesh sieve, obtains Fructus Broussonetiae micropowder;The volumetric concentration that Fructus Broussonetiae micropowder is put into its quality 3-4 times amount is Soaking 7-8h in the ethanol water of 85-92%, then carry out ultrasonic extraction under the conditions of 52-56 DEG C, ultrasonic power is 480-520W, ultrasonic frequency is 20kHz, and extraction time is 4-5h, separates to obtain filtrate and filtering residue;Filtering residue is added its quality In the water of 4-6 times amount, heated and boiled is extracted three times, and each extraction time is 2-3h, merges three extracting solution and filtrate, filters, dense Being reduced to relative density at 55 DEG C is the thick paste of 1.16-1.18, dries, and pulverizes, and crosses 120-150 mesh sieve, obtains Fructus Broussonetiae extract;
The preparation process of described Herba veronicae herb extract is: pulverized by Herba veronicae herb, crosses 40-80 mesh sieve, obtains Herba veronicae powder;Herba veronicae powder is added the ethanol water that volumetric concentration is 86-88% of its quality 4-5 times amount, heating Backflow 2-3h, extracts, filters to obtain the first extracting solution and the first filtering residue;Continue to add medicinal residues to be equivalent to medicinal residues quality 3-4 times amount The ethanol water that volumetric concentration is 80-84%, be heated to reflux 1-2h, extract, filter obtain the second extracting solution and second filter Slag;First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes ethanol, is dried, it is thus achieved that dry cream;With carbon dioxide for extraction Taking agent, the ethanol water with volumetric concentration as 82-86%, as entrainer, carries out subcritical abstraction to the second filtering residue, and wherein two Carbonoxide: the mass ratio of the second filtering residue is 2-2.5:1, extraction temperature 22-23 DEG C, extracting pressure 3.5-3.8MPa, cycling extraction 3-4 time, extract 15-20min, extractant flow velocity 40-42L/h every time, be extracted liquid;At 22-23 DEG C, pressure 0.6-0.8MPa Under the conditions of, separating and extracting liquid, obtain separating liquid;Liquid will be separated mix with dry cream, and dry, pulverize, cross 200-250 mesh sieve, obtain mother-in-law Procumbent speedwell herb extract;
The preparation process of described yellow violent dish root extract is: by violent for Huang dish root coarse pulverization, add its quality 0.22- The amylase of 0.25% or cellulase degradation 2-3 days, add the water of the 6-8 times amount of its quality, utilize at a temperature of 58-62 DEG C The microwave radiation exaraction of 420-450W 3 times, united extraction liquid, filters, crosses macroporous resin column, collect lower fluid injection;First wash with water big Hole resin column reacts to sugar-free, then with the ethanol water eluting that volumetric concentration is 50-55%, collects ethanol elution and be concentrated into Taste without alcohol;Eluent by lower fluid injection with without alcohol taste merges, and concentrates, is spray-dried to obtain yellow violent dish root extract.
As the further scheme of the present invention: according to mass percent, be made up of following components: mosquito leaf extract 2.4-2.5%, Fructus Broussonetiae extract 0.25-0.32%, Herba veronicae herb extract 1.3-1.4%, yellow violent dish root extract 0.65-0.68%, mineral oil 23-24%, Fructrs Hippophae seed oil 1.3-1.4%, cetyl lactate 6.2-6.4%, lactic acid Herba Menthae Ester 5.3-5.5%, vaseline 13-14%, guar gum 1.6-1.8%, water 43-44%.
As the further scheme of the present invention: according to mass percent, be made up of following components: mosquito leaf extract 2.4%, Fructus Broussonetiae extract 0.3%, Herba veronicae herb extract 1.35%, yellow violent dish root extract 0.65%, mineral oil 23%, Fructrs Hippophae seed oil 1.3%, cetyl lactate 6.4%, menthyl lactate 5.4%, vaseline 13.5%, guar gum 1.7%, water 44%.
The property of medicine and the drug effect of the Chinese medicine that the invention described above is used are as follows:
Mosquito son tree, calls Folium Eucalypti Robustae, for Myrtaceae eucalyptus plant Folium Eucalypti Robustae, is used as medicine with leaf, fresh leaf (Eucalyptus Han volatile oil Oil) about 0.7%, main body of oil is eucalyptol (cineole), thymol (thymol), ancient hold (guajazulene, C15H18), globulol (globulol, C16H26O), pinocarvone (l-pinocarvon, C10H14O, additionally, still sour, bitter containing Folium eucalypti globueli (Eucalyptus globulus Labill.) Taste matter, tannin, resin etc., the antimicrbial power of Folium Eucalypti Robustae is relatively strong, and antimicrobial spectrum is the widest;Property flat, the micro-hardship pungent, micro-of taste, have dispelling wind antipyretic, Effect that inhibiting bacteria and diminishing inflammation, anticorrosion are antipruritic;For preventing influenza, epidemic cerebrospinal meningitis, control upper respiratory tract infection, pharynx Laryngitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, enteritis, dysentery, filaricide;Burn and scald, cellulitis, breast are controlled in external Adenitis, furuncle and phyma, erysipelas, paddy-field dermatitis, skin eczema, tinea pedis, skin degerming.
Fructus Broussonetiae, for the dry mature fruit of moraceae plants Broussonetia papyrifera, cold in nature, sweet in the mouth, return liver, kidney channel, have the kidney invigorating liver heat removing, Improving eyesight, effect of diuresis;For soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, dizzy blurred vision, the raw nebula film of mesh, edema distension.
Herba veronicae, for the herb of Scrophulariaceae brooklime Herba veronicae, sweet in the mouth, light, cool in nature, return liver, kidney channel, there is benefit The strong waist of kidney, effect of removing toxic substances and promoting subsidence of swelling;It is usually used in the diseases such as lumbago due to renal deficiency, hernia, painful and swollen testis, women leucorrhea, carbuncle.
Yellow violent dish, another name Gelsemium elegans Benth., Herba Gelsemii Elegantis, big tea medicine, artillery leaf, Hemerocallis citrina Baroni hardship are climing, for Loganiaceae Gelsemium el-egans platymiscium recklessly Climing rattan, with root, leaf and all herbal medicine, warm in nature, bitter in the mouth, pungent, very toxic, have counteracting toxic substances draw out pus by applying a plaster to the affected part, the merit of eliminating stasis to stop pain, killing parasites for relieving itching Effect;Skin eczema, tinea corporis, tinea pedis, traumatic injury, fracture, hemorrhoid, furuncle, leprosy are controlled in external;Also can kill maggot, wriggler.
The preparation method of described body-building weight-reducing compositions, comprises the following steps:
(1) mineral oil, Fructrs Hippophae seed oil, cetyl lactate and menthyl lactate are put in oil phase pot and mix, add Heat, to 55-60 DEG C, opens stirring, and mixing speed controls at 25-30r/min, and stirring makes material dissolution be incubated 10-the most afterwards 15min, obtains oil phase;
(2) vaseline, guar gum and water are put in aqueous phase pot and mix, be heated to 78-82 DEG C, open stirring, stirring Speed controlling makes material dissolution be incubated 35-40min the most afterwards in 25-30r/min, stirring, obtains aqueous phase;
(3) first by aqueous phase suction emulsifying pot, then by oil phase suction, opening stirring, mixing speed controls at 50-60r/min; Then opening homogenizing 8-10min, homogenizing speed controlling, at 2300-2500r/min, is incubated 18-20min, vacuumizing and defoaming;Treat breast Change pot to be cooled to when 46-48 DEG C add mosquito leaf extract, Fructus Broussonetiae extract, Herba veronicae herb extract, yellow violent dish root Extract, after stirring, vacuumizing and defoaming, discharging after cooling again, obtains unguentum.
The application in terms of preparing body-building weight-reducing skin care item of the described body-building weight-reducing compositions.
The application in terms of the vigorous and graceful clothing of preparation of the described body-building weight-reducing compositions, is coated in this body-building weight-reducing compositions The one side of the Web materials that the textile weaving screw thread woven materials using band elastic is made, then this is coated with body-building weight-reducing combination On the Web materials of thing, the one side of uncoated body-building weight-reducing compositions adheres to Web materials with in the vigorous and graceful clothing of material Face, thus prepare vigorous and graceful clothing.According to the fat thickness of different parts, the coating weight of described body-building weight-reducing compositions is 4- 8mg/cm2
Compared with prior art, the invention has the beneficial effects as follows:
The present invention uses mosquito leaf extract, Fructus Broussonetiae extract, Herba veronicae herb extract and Huang Meng dish root to extract Thing these four component is compounding to be used, and each component is the most collaborative, skin care while supplementing multiple nutrient for skin, working substance Skin can be penetrated deep into, suppress Fat Accumulation, accelerate steatolysis, play the effect of body-building weight-reducing;The present invention not only effect shows Write, have no side effect, and easy to use, the purpose of body-building weight-reducing only need to can be realized by daily nursing;This combination After thing can also be by being coated on vigorous and graceful clothing inner face, wearing a period of time just can realize the purpose of body-building weight-reducing, in fitness While weight reducing, it is also possible to be engaged in basic daily routines.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, Obviously, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of body-building weight-reducing compositions, according to mass percent, it is made up of following components: mosquito Subtree leaf extract 2.3%, Fructus Broussonetiae extract 0.20%, Herba veronicae herb extract 1.2%, yellow violent dish root extract 0.60%, mineral oil 22%, Fructrs Hippophae seed oil 1.2%, cetyl lactate 7%, menthyl lactate 6%, vaseline 12%, melon That glue 1.5%, water 46%.
The preparation method of described body-building weight-reducing compositions, comprises the following steps:
(1) preparation of mosquito leaf extract: by mosquito leaves coarse pulverization, add the volumetric concentration of 5 times amount of its quality Being to soak after 2h in the ethanol water of 78%, carry out ultrasonic extraction under the conditions of 46 DEG C, ultrasonic power is 720W, ultrasonic Wave frequency is 20kHz, and extraction time is 1.8h, separates to obtain the first extracting solution and the first filtering residue;By the first filtering residue and mosquito leaves After the water mix homogeneously of 4 times amount of quality, utilize the microwave radiation exaraction 4min that power is 380W, obtain the second extracting solution;By One extracting solution and the second extracting solution merge, and filter, through being concentrated in vacuo to without alcohol taste, obtain concentrated solution;By macroporous resin on concentrated solution Post, successively with the water elution of 7 times of column volumes, the ethanol water eluting that volumetric concentration is 58% of 5 times of column volumes, 3 times of cylinders The long-pending ethanol water eluting that volumetric concentration is 90%, merges eluent, and eluent is concentrated into the 1/3 of proper mass, dries, Pulverize, cross 300 mesh sieves, obtain mosquito leaf extract, standby;
(2) preparation of Fructus Broussonetiae extract: Fructus Broussonetiae is placed in super micron mill pulverizing 70min, crosses 350 mesh sieves, Obtain Fructus Broussonetiae micropowder;Fructus Broussonetiae micropowder is put in the ethanol water that volumetric concentration is 88% of its quality 3 times amount and soak 7-8h, then carries out ultrasonic extraction under the conditions of 53 DEG C, and ultrasonic power is 500W, and ultrasonic frequency is 20kHz, during extraction Between be 4.5h, separate to obtain filtrate and filtering residue;Heated and boiled extraction three times in the water of 5 times amount that filtering residue is added its quality, every time Extraction time is 3h, merges three extracting solution and filtrate, filters, and being concentrated into relative density at 55 DEG C is the thick paste of 1.16, dries, Pulverize, cross 150 mesh sieves, obtain Fructus Broussonetiae extract, standby;
(3) preparation of Herba veronicae herb extract: pulverized by Herba veronicae herb, crosses 60 mesh sieves, obtains Herba veronicae powder;Will Herba veronicae powder adds the ethanol water that volumetric concentration is 88% of its quality 5 times amount, is heated to reflux 2.5h, extracts, and filters Obtain the first extracting solution and the first filtering residue;Continue medicinal residues add the second that volumetric concentration is 82% being equivalent to medicinal residues quality 4 times amount Alcohol-water solution, is heated to reflux 2h, extracts, and filters and obtains the second extracting solution and the second filtering residue;First extracting solution and second are extracted Liquid merges, and concentrating under reduced pressure removes ethanol, is dried, it is thus achieved that dry cream;With carbon dioxide as extractant, with volumetric concentration as 82-86% Ethanol water be entrainer, the second filtering residue is carried out subcritical abstraction, wherein carbon dioxide: the mass ratio of the second filtering residue is 2.5:1, extraction temperature 22 DEG C, extracting pressure 3.6MPa, cycling extraction 4 times, extract 18min, extractant flow velocity 40L/h every time, It is extracted liquid;22 DEG C, under the conditions of pressure 0.7MPa, separating and extracting liquid, obtain separating liquid;Liquid will be separated mix with dry cream, Dry, pulverize, cross 250 mesh sieves, obtain Herba veronicae herb extract, standby;
(4) preparation of yellow violent dish root extract: by violent for Huang dish root coarse pulverization, add amylase or the fibre of its quality 0.24% Dimension element enzyme enzymolysis 3 days, adds the water of 7 times amount of its quality, utilizes the microwave radiation exaraction 3 times of 450W, close at a temperature of 60 DEG C And extracting solution, filter, cross macroporous resin column, collect lower fluid injection;First wash macroporous resin column with water to react to sugar-free, denseer with volume Degree is the ethanol water eluting of 52%, collects ethanol elution and is concentrated into without alcohol taste;By lower fluid injection with without the eluent of alcohol taste Merge, concentrate, be spray-dried to obtain yellow violent dish root extract, standby;
(5) mineral oil, Fructrs Hippophae seed oil, cetyl lactate and menthyl lactate are put in oil phase pot and mix, add Heat, to 58 DEG C, opens stirring, and mixing speed controls at 25r/min, and stirring makes material dissolution be incubated 15min the most afterwards, obtains oil Phase;
(6) vaseline, guar gum and water are put in aqueous phase pot and mix, be heated to 80 DEG C, open stirring, mixing speed Controlling at 25r/min, stirring makes material dissolution be incubated 40min the most afterwards, obtains aqueous phase;
(7) first by aqueous phase suction emulsifying pot, then by oil phase suction, opening stirring, mixing speed controls at 50r/min;Connect Unlatching homogenizing 10min, homogenizing speed controlling, at 2500r/min, is incubated 20min, vacuumizing and defoaming;Pot to be emulsified is cooled to 47 DEG C time add mosquito leaf extract, Fructus Broussonetiae extract, Herba veronicae herb extract, yellow violent dish root extract, stir After vacuumizing and defoaming, discharging after cooling again, obtain unguentum.
Embodiment 2
In the embodiment of the present invention, a kind of body-building weight-reducing compositions, according to mass percent, it is made up of following components: mosquito Subtree leaf extract 2.8%, Fructus Broussonetiae extract 0.35%, Herba veronicae herb extract 1.5%, yellow violent dish root extract 0.75%, mineral oil 25%, Fructrs Hippophae seed oil 1.6%, cetyl lactate 6%, menthyl lactate 5%, vaseline 15%, melon That glue 2.0%, water 40%.
The preparation method of described body-building weight-reducing compositions is same as in Example 1.
Embodiment 3
In the embodiment of the present invention, a kind of body-building weight-reducing compositions, according to mass percent, according to mass percent, Be made up of following components: mosquito leaf extract 2.4%, Fructus Broussonetiae extract 0.25%, Herba veronicae herb extract 1.3%, Yellow violent dish root extract 0.65%, mineral oil 24%, Fructrs Hippophae seed oil 1.3%, cetyl lactate 6.2%, menthyl lactate 5.3%, vaseline 13%, guar gum 1.6%, water 44%.
The preparation method of described body-building weight-reducing compositions is same as in Example 1.
Embodiment 4
In the embodiment of the present invention, a kind of body-building weight-reducing compositions, according to mass percent, according to mass percent, Be made up of following components: mosquito leaf extract 2.5%, Fructus Broussonetiae extract 0.32%, Herba veronicae herb extract 1.4%, Yellow violent dish root extract 0.68%, mineral oil 23%, Fructrs Hippophae seed oil 1.4%, cetyl lactate 6.4%, menthyl lactate 5.5%, vaseline 14%, guar gum 1.8%, water 43%.
The preparation method of described body-building weight-reducing compositions is same as in Example 1.
Embodiment 5
In the embodiment of the present invention, a kind of body-building weight-reducing compositions, according to mass percent, according to mass percent, Be made up of following components: mosquito leaf extract 2.4%, Fructus Broussonetiae extract 0.3%, Herba veronicae herb extract 1.35%, Yellow violent dish root extract 0.65%, mineral oil 23%, Fructrs Hippophae seed oil 1.3%, cetyl lactate 6.4%, menthyl lactate 5.4%, vaseline 13.5%, guar gum 1.7%, water 44%.
The preparation method of described body-building weight-reducing compositions is same as in Example 1.
The present invention uses mosquito leaf extract, Fructus Broussonetiae extract, Herba veronicae herb extract and Huang Meng dish root to extract Thing these four component is compounding to be used, and each component is the most collaborative, skin care while supplementing multiple nutrient for skin, working substance Skin can be penetrated deep into, suppress Fat Accumulation, accelerate steatolysis, play the effect of body-building weight-reducing.
The medicine of the present invention body-building weight-reducing effect to overweight people is further illustrated below by clinical data.
1, basic data
1.1 study subject
Choose simple obesity patient totally 960 example, the age between 18-59 year, wherein women 544 example, male 416 Example.This 960 example patient is divided at random cream 1-5 group, vigorous and graceful clothing 1-5 group, right without extract cream 1-5 group, blank According to group totally 16 groups, often organizing 60 examples, between each group, the sex of patient, age, the course of disease are without explicitly difference, have comparability.
1.2 diagnostic criteria
Only real overweight people (containing degree overweight people light, middle and high) is included in the object of observation:
Mild Obesity: body weight (kg) > [height (cm)-100] × 0.9 × 1.2;
Central obesity: body weight (kg) > [height (cm)-100] × 0.9 × 1.4;
High obesity: body weight (kg) > [height (cm)-100] × 0.9 × 1.6.
2, test method
Cream 1-5 group: use the cream that embodiment 1-5 prepares respectively, three times a day, take every time appropriate outer wipe in abdominal part and Fat local, and with referring to abdomen massage counterclockwise first clockwise, rear until absorption, continuous 60 days, period disabled other oral, outer wiping Diet products and massage acupuncture fat-reducing maneuver.Period performs early to eat nice morning, the noon has enough early, evening eats and early eats few requirement.
Vigorous and graceful clothing 1-5 group: dress is coated with the vigorous and graceful clothing of cream of embodiment 1-5 (these fitness clothing are to adopt respectively Weave what screw thread woven materials was made with the cotton textiles that band is elastic, respectively the cream that embodiment 1-5 prepares is coated on and gym wear The one side of the Web materials that dress material is identical, then the one side of body-building weight-reducing compositions uncoated on this Web materials is adhered to this On vigorous and graceful clothing inner face, wearing for experimenter, wherein, the coating weight of cream is 4-8mg/cm2, be suitable to obese degree different Each position use), carry out daily routines, wear every day twice, each two hours, continuous 60 days, it is oral, outer that period disables other Wipe diet products and massage acupuncture fat-reducing maneuver.Period performs early to eat nice morning, the noon has enough early, evening eats and early eats few requirement.
The 1-5 group of cream without extract: use respectively be adjusted according to the constituent content described in embodiment 1-5 and method and (this does not has mosquito leaf extract, Fructus Broussonetiae extract, Herba veronicae herb to carry without extract cream to the cream without extract prepared Taking thing and Huang Meng dish root extract these four component, remaining constituent content and preparation method are all identical with corresponding embodiment), often , take appropriate outer wipe in abdominal part and fat local days for three times every time, and with refer to abdomen the most clockwise, rear massage counterclockwise until absorption, Continuous 60 days, period disabled other oral, outer wiping diet products and massage acupuncture fat-reducing maneuver.Period perform early to eat nice early, Noon has enough early, evening eats and early eats few requirement.
Blank group: continuous 60 days, period disables other oral, outer wiping diet products and massage acupuncture fat-reducing maneuver. Period performs early to eat nice morning, the noon has enough early, evening eats and early eats few requirement.
3, observation index
3.1 ordinary circumstance
Medical history, history of present illness, diet, heart rate, blood pressure.Main detection: the situations such as complication.
3.2 lab index
Routine blood test, routine urinalysis, stool routine, biochemical indicator, B ultrasonic (abdominal part), electrocardiogram, x-ray fluoroscopy of chest.
3.3 Body Mass Index
Recovery from illness: body weight returns back to arm's length standard and follows up a case by regular visits to non-bounce-back person half a year;
Effective: to deduct more than 40% person of the body weight that exceeds the quata;
Effective: to deduct more than 20% person of the body weight that exceeds the quata;
Invalid: to deduct 20% (without 20%) the following person of the body weight that exceeds the quata.
3.4 other foundations
Though body weight is unchanged but eight encloses (neck circumference, upper-arm circumference, stomach enclose, abdominal circumference, lower abdominal circumference, hip circumference, upper stock enclose, lower stock encloses) and reduce ?;Though body weight is unchanged but outward appearance reduces.
4, result of the test
4.1 ordinary circumstance
Tested group of cream 1-5 group: no abnormality seen after observing at 60 days such as former clinical manifestation person without exception;As tested front center Rate is too fast, slight Hypertension person all has improvement in various degree after 60 days observe;Lip is more ruddy, it is more smooth and easy, smart to breathe God's state turns for the better, takes action more freely.
Tested group of vigorous and graceful clothing 1-5 group: no abnormality seen after observing at 60 days such as former clinical manifestation person without exception;Such as test Front rapid heart rate, slight Hypertension person all have significantly improvement after 60 days observe;Lip is more ruddy, it is more smooth and easy, smart to breathe God's state turns for the better, takes action more freely.
Tested group of the 1-5 group of cream without extract: no abnormality seen after observing at 60 days such as former clinical manifestation person without exception;As Before test, rapid heart rate, slight Hypertension person have slight improvement after 60 days observe.
Tested group of blank group: no abnormality seen after observing at 60 days such as former clinical manifestation person without exception.
4.2 experimental index
Tested group of cream 1-5 group: as former without routine blood test, routine urinalysis, stool routine, biochemical indicator, B ultrasonic (abdominal part), electrocardio Figure, x-ray fluoroscopy of chest exception person change the most without exception;Before the test such as Hyperlipidemia, there is fatty liver, have gallbladder Scorching, have hemorrhoid person then to have alleviation trend in various degree.
Tested group of vigorous and graceful clothing 1-5 group: as former without routine blood test, routine urinalysis, stool routine, biochemical indicator, B ultrasonic (abdominal part), Electrocardiogram, x-ray fluoroscopy of chest exception person change the most without exception;Before the test such as Hyperlipidemia, there is fatty liver, have gallbladder Capsulitis, hemorrhoid person is had then to have improvement in various degree.
Tested group of the 1-5 group of cream without extract: as former without routine blood test, routine urinalysis, stool routine, biochemical indicator, B ultrasonic (abdomen Portion), electrocardiogram, x-ray fluoroscopy of chest exception person change the most without exception;Before the test as Hyperlipidemia, have fatty liver, There is cholecystitis, have hemorrhoid person then to have slight improvement.
Tested group of blank group: as former without routine blood test, routine urinalysis, stool routine, biochemical indicator, B ultrasonic (abdominal part), electrocardio Figure, x-ray fluoroscopy of chest exception person change the most without exception.
4.3 Body Mass Index
The Body Mass Index that table 1 is respectively organized
Project Case load Recovery from illness number Effective number Significant figure Cure rate Total effective rate
Cream 1 group 60 4 23 25 6.67% 86.67%
Cream 2 groups 60 5 24 24 8.33% 88.33%
Cream 3 groups 60 5 25 24 8.33% 90.00%
Cream 4 groups 60 6 26 22 10.00% 90.00%
Cream 5 groups 60 8 22 26 13.33% 93.33%
Vigorous and graceful clothing 1 group 60 5 24 24 8.33% 88.33%
Vigorous and graceful clothing 2 groups 60 5 27 23 8.33% 91.67%
Vigorous and graceful clothing 3 groups 60 6 23 26 10.00% 91.67%
Vigorous and graceful clothing 4 groups 60 7 25 24 11.67% 93.33%
Vigorous and graceful clothing 5 groups 60 9 26 23 15% 96.67%
Cream without extract 1 group 60 0 2 12 0% 23.33%
Cream without extract 2 groups 60 0 2 13 0% 25.00%
Cream without extract 3 groups 60 0 3 14 0% 28.33%
Cream without extract 4 groups 60 0 4 16 0% 33.33%
Cream without extract 5 groups 60 0 5 17 0% 36.67%
Blank group 60 0 0 2 0% 3.33%
5, conclusion (of pressure testing)
Above-mentioned test proves, and compared with extract cream 1-5 group and blank group, and unguentum 1-5 group and vigorous and graceful clothing 1-5 group all has obvious body-building weight-reducing effect, illustrates that the present composition is to extract at mosquito leaf extract, Fructus Broussonetiae Just have so under the common effect of thing, Herba veronicae herb extract and Huang Meng dish root extract these four component and remaining component Significantly curative effect;Compared with unguentum 1-5 group, the body-building weight-reducing effect of vigorous and graceful clothing 1-5 group is more excellent, illustrates to be coated with this unguentum Cloth is after elastic vigorous and graceful clothing inner face, and experimenter wears this gym wear when putting into row daily routines, subjects skin with Clothing the most slightly rub and make unguentum slowly and fully penetrate into skin promotion absorption, thus have and smear unguentum also relatively by several times Massage the body-building weight-reducing effect that the unguentum 1-5 group absorbed is more excellent.
Although nonresponder's body weight change of unguentum 1-5 group and vigorous and graceful clothing 1-5 group is little but eight encloses and feel all have with outward appearance Change;All experimenters of unguentum 1-5 group and vigorous and graceful clothing 1-5 group in various degree conscious healthy.
In sum, the present composition not only effect is notable, has no side effect, and easy to use, only need to lead to Cross daily nursing and can realize the purpose of body-building weight-reducing;After said composition can also be by being coated on vigorous and graceful clothing inner face, dress A period of time just can realize the purpose of body-building weight-reducing, while body-building weight-reducing, it is also possible to is engaged in basic daily routines.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie In the case of the spirit or essential attributes of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter From the point of view of which point, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit requires rather than described above limits, it is intended that all by fall in the implication of equivalency and scope of claim Change is included in the present invention.
Although moreover, it will be appreciated that this specification is been described by according to embodiment, but the most each embodiment only wraps Containing an independent technical scheme, this narrating mode of description is only that for clarity sake those skilled in the art should Description can also be formed those skilled in the art through appropriately combined as an entirety, the technical scheme in each embodiment May be appreciated other embodiments.

Claims (6)

1. a body-building weight-reducing compositions, it is characterised in that according to mass percent, be made up of following components: mosquito leaves Extract 2.3-2.8%, Fructus Broussonetiae extract 0.20-0.35%, Herba veronicae herb extract 1.2-1.5%, yellow violent dish root carry Take thing 0.60-0.75%, mineral oil 22-25%, Fructrs Hippophae seed oil 1.2-1.6%, cetyl lactate 6-7%, lactic acid Herba Menthae Ester 5-6%, vaseline 12-15%, guar gum 1.5-2.0%, water 40-46%;
The preparation process of described mosquito leaf extract is: by mosquito leaves coarse pulverization, add the body of the 5-6 times amount of its quality Volume concentrations be 76-78% ethanol water in soak after 2-3h, under the conditions of 45-48 DEG C, carry out ultrasonic extraction, ultrasound wave Power is 650-780W, and ultrasonic frequency is 20kHz, and extraction time is 1.5-2h, separates to obtain the first extracting solution and the first filtering residue; After being mixed homogeneously by the water of the first filtering residue with the 3-4 times amount of mosquito leaves quality, utilize the microwave-assisted that power is 360-380W Extract 3-5min, obtain the second extracting solution;First extracting solution and the second extracting solution are merged, filters, through being concentrated in vacuo to without alcohol taste, Obtain concentrated solution;By macroporous resin column on concentrated solution, successively by the water elution of 7-8 times of column volume, the volumetric concentration of 5-6 times of column volume For the ethanol water eluting of 55-60%, the volumetric concentration of 3-4 times of column volume is the ethanol water eluting of 88-92%, merges Eluent, is concentrated into the 1/3-1/4 of proper mass by eluent, dries, and pulverizes, and crosses 250-350 mesh sieve, obtains mosquito leaves and extracts Thing;
The preparation process of described Fructus Broussonetiae extract is: Fructus Broussonetiae is placed in super micron mill pulverizing 60-80min, mistake 350-400 mesh sieve, obtains Fructus Broussonetiae micropowder;The volumetric concentration that Fructus Broussonetiae micropowder is put into its quality 3-4 times amount is 85-92%'s Soaking 7-8h in ethanol water, then carry out ultrasonic extraction under the conditions of 52-56 DEG C, ultrasonic power is 480-520W, Ultrasonic frequency is 20kHz, and extraction time is 4-5h, separates to obtain filtrate and filtering residue;Filtering residue is added the 4-6 times amount of its quality In water, heated and boiled is extracted three times, and each extraction time is 2-3h, merges three extracting solution and filtrate, filters, is concentrated into 55 DEG C Lower relative density is the thick paste of 1.16-1.18, dries, and pulverizes, and crosses 120-150 mesh sieve, obtains Fructus Broussonetiae extract;
The preparation process of described Herba veronicae herb extract is: pulverized by Herba veronicae herb, crosses 40-80 mesh sieve, obtains grandmother Receive powder;Herba veronicae powder is added the ethanol water that volumetric concentration is 86-88% of its quality 4-5 times amount, is heated to reflux 2-3h, extracts, filters to obtain the first extracting solution and the first filtering residue;Continue medicinal residues add the body being equivalent to medicinal residues quality 3-4 times amount Volume concentrations is the ethanol water of 80-84%, is heated to reflux 1-2h, extracts, and filters and obtains the second extracting solution and the second filtering residue;Will First extracting solution and the second extracting solution merge, and concentrating under reduced pressure removes ethanol, are dried, it is thus achieved that dry cream;With carbon dioxide as extractant, Ethanol water with volumetric concentration as 82-86%, as entrainer, carries out subcritical abstraction, wherein titanium dioxide to the second filtering residue Carbon: the mass ratio of the second filtering residue is 2-2.5:1, extraction temperature 22-23 DEG C, extracting pressure 3.5-3.8MPa, cycling extraction 3-4 Secondary, extract 15-20min, extractant flow velocity 40-42L/h every time, be extracted liquid;At 22-23 DEG C, pressure 0.6-0.8MPa bar Under part, separating and extracting liquid, obtain separating liquid;Liquid will be separated mix with dry cream, and dry, pulverize, cross 200-250 mesh sieve, obtain grandmother Receive herb extract;
The preparation process of described yellow violent dish root extract is: by violent for Huang dish root coarse pulverization, add its quality 0.22-0.25% Amylase or cellulase degradation 2-3 days, add the water of the 6-8 times amount of its quality, utilize 420-450W at a temperature of 58-62 DEG C Microwave radiation exaraction 3 times, united extraction liquid, filter, cross macroporous resin column, collect lower fluid injection;First wash macroporous resin column with water React to sugar-free, then with the ethanol water eluting that volumetric concentration is 50-55%, collect ethanol elution and be concentrated into without alcohol taste; Eluent by lower fluid injection with without alcohol taste merges, and concentrates, is spray-dried to obtain yellow violent dish root extract.
Body-building weight-reducing compositions the most according to claim 1, it is characterised in that according to mass percent, by following group Divide and make: mosquito leaf extract 2.4-2.5%, Fructus Broussonetiae extract 0.25-0.32%, Herba veronicae herb extract 1.3- 1.4%, yellow violent dish root extract 0.65-0.68%, mineral oil 23-24%, Fructrs Hippophae seed oil 1.3-1.4%, cetyl lactic acid Ester 6.2-6.4%, menthyl lactate 5.3-5.5%, vaseline 13-14%, guar gum 1.6-1.8%, water 43-44%.
Body-building weight-reducing compositions the most according to claim 2, it is characterised in that according to mass percent, by following group Divide and make: mosquito leaf extract 2.4%, Fructus Broussonetiae extract 0.3%, Herba veronicae herb extract 1.35%, yellow violent dish root Extract 0.65%, mineral oil 23%, Fructrs Hippophae seed oil 1.3%, cetyl lactate 6.4%, menthyl lactate 5.4%, all Intellectual circle 13.5%, guar gum 1.7%, water 44%.
4. according to the preparation method of the arbitrary described body-building weight-reducing compositions of claim 1-3, it is characterised in that include following step Rapid:
(1) mineral oil, Fructrs Hippophae seed oil, cetyl lactate and menthyl lactate are put in oil phase pot and mix, be heated to 55-60 DEG C, opening stirring, mixing speed controls at 25-30r/min, and stirring makes material dissolution be incubated 10-15min the most afterwards, To oil phase;
(2) vaseline, guar gum and water are put in aqueous phase pot and mix, be heated to 78-82 DEG C, open stirring, mixing speed Controlling at 25-30r/min, stirring makes material dissolution be incubated 35-40min the most afterwards, obtains aqueous phase;
(3) first by aqueous phase suction emulsifying pot, then by oil phase suction, opening stirring, mixing speed controls at 50-60r/min;Then Opening homogenizing 8-10min, homogenizing speed controlling, at 2300-2500r/min, is incubated 18-20min, vacuumizing and defoaming;Pot to be emulsified It is cooled to when 46-48 DEG C add mosquito leaf extract, Fructus Broussonetiae extract, Herba veronicae herb extract, yellow violent dish root extraction Thing, after stirring, vacuumizing and defoaming, discharging after cooling again, obtains unguentum.
5. the application in terms of preparing body-building weight-reducing skin care item of the body-building weight-reducing compositions as described in claim 1-3 is arbitrary.
6. the application in terms of the vigorous and graceful clothing of preparation of the body-building weight-reducing compositions as described in claim 1-3 is arbitrary.
CN201610817511.1A 2016-09-12 2016-09-12 A kind of body-building weight-reducing compositions and preparation method and application Pending CN106266173A (en)

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CN104815037A (en) * 2015-05-11 2015-08-05 赵振荣 Drug for treating rheumatism accumulated toxin type chronic eczema and preparation method of drug
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