CN106236833A - A kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease - Google Patents
A kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, relate to a kind of pharmaceutical composition with Chinese herbal medicine as raw material, a kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease.This pharmaceutical composition is the medicament made by the material medicine by following weight proportioning: Radix Salviae Miltiorrhizae 80 ~ 200, Ganoderma 80 ~ 200, Radix Notoginseng 80 ~ 180, Rhizoma Chuanxiong 80 ~ 180, Flos Carthami 50 ~ 150, Radix Panacis Quinquefolii 50 ~ 150, Hirudo 40 ~ 100, Pheretima 40 ~ 100, the Radix Astragali 20 ~ 80, Radix Angelicae Sinensis 10 ~ 40.This pharmaceutical composition is with low cost, and formula is reasonable, has the effect of invigorating qi and benefiting blood, blood circulation promoting and blood stasis dispelling, dredging collateral, vessel softening.The patient heavier to coronary atherosclerotic heart disease, operation risk is big also has preferable curative effect, can not do the treatment of heart pass art.Suitable long-term taking, has III grade of patient of coronary heart disease function to take pharmaceutical composition of the present invention and checks after 3 years, and clinical symptoms disappears substantially.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of pharmaceutical composition with Chinese herbal medicine as raw material, be specially one treatment
The pharmaceutical composition of cardiovascular and cerebrovascular disease.
Background technology
Along with improving constantly of people's living standard, drink, be satiated with food, operating pressure increases, cardio-cerebrovascular
Sickness rate rises year by year, age of onset rejuvenation, the healthy and life security of serious harm people.Cardio-cerebrovascular disease
Disease refers to the disease that heart coronary artery atherosclerotic disease and cerebral artery vessel hardening cause.Heart coronary artery blood vessel medicated porridge sample
Hardening disease causes cardiovascular narrow, even infraction, angina pectoris, weak, the heart are tired, gas is tight to cause heart ischemia, patient to occur,
Acute myocardial infarction is even occurred to cause death.The disease that causes of cerebral artery vessel hardening be cerebral hemorrhage, cerebral infarction, cerebral infarction,
Brain atrophy, time serious, there is quadriplegia, aphasia, dementia in patient, even dead.Cardiovascular and cerebrovascular disease has " sickness rate
Height, mortality rate are high, disability rate height, relapse rate are high, complication is many ", the feature of " four is high by more than ", at present, China's cardiovascular and cerebrovascular vessel disease
Patient alreadys more than 2.7 hundred million people, and cardiovascular and cerebrovascular disease has become the number one killer that human death's cause of disease is the highest, drastically influence
The health of people.
At present, the method for the treatment of diseases of cardiovascular and cerebrovascular systems is a lot of both at home and abroad, mainly has Chinese medicine, western modern medicine to control
Treatment, operative treatment etc..For a long time, doctor trained in Western medicine typically uses anticoagulant, adjusts the treatment of fat, bypass surgery.Patient needs lifelong medication,
Cause patients ' life quality low.
Summary of the invention
It is an object of the invention to for above-mentioned technical problem, it is provided that a kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease.Should
Drug regimen composition formula is reasonable, and has the effect of invigorating qi and benefiting blood, blood circulation promoting and blood stasis dispelling, dredging collateral and vessel softening.
To achieve these goals, the concrete technical scheme of the present invention is:
A kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease, it is the medicament made by the material medicine by following weight proportioning.
Radix Salviae Miltiorrhizae 80 ~ 200, Ganoderma 80 ~ 200, Radix Notoginseng 80 ~ 180, Rhizoma Chuanxiong 80 ~ 180, Flos Carthami 50 ~ 150, Radix Panacis Quinquefolii 50 ~ 150,
Hirudo 40 ~ 100, Pheretima 40 ~ 100, the Radix Astragali 20 ~ 80, Radix Angelicae Sinensis 10 ~ 40.
The preferred weight proportioning of this pharmaceutical composition is: Radix Salviae Miltiorrhizae 100 ~ 180, Ganoderma 100 ~ 180, Radix Notoginseng 100 ~ 160, Rhizoma Chuanxiong
100 ~ 160, Flos Carthami 70 ~ 170, Radix Panacis Quinquefolii 70 ~ 120, Hirudo 60 ~ 80, Pheretima 60 ~ 80, the Radix Astragali 40 ~ 60, Radix Angelicae Sinensis 20 ~ 30.
The optimum weight proportioning of this pharmaceutical composition is: Radix Salviae Miltiorrhizae 160, Ganoderma 160, Radix Notoginseng 150, Rhizoma Chuanxiong 140, Flos Carthami 100,
Radix Panacis Quinquefolii 80, Hirudo 70, Pheretima 70, the Radix Astragali 50, Radix Angelicae Sinensis 20.
This pharmaceutical composition can produce into " flashing ball ", " concentrated pill ", " tablet ", " capsule ".Also adjuvant Mel can be added, raw
Produce " water-honeyed pill ".
By as follows for step that the component of above-mentioned each pharmaceutical composition is prepared as flashing ball:
(1) Hirudo crude drug is the most accurately weighed, with pressure cooker Steam by water bath 30 minutes under the temperature conditions of 120 DEG C,
Dry for standby；The condition dried is: temperature 80 DEG C ~ 110 DEG C, drying time is 10 ~ 15 minutes.
(2) Radix Salviae Miltiorrhizae, Ganoderma, Radix Notoginseng, Rhizoma Chuanxiong, Flos Carthami, Radix Panacis Quinquefolii, Pheretima, the Radix Astragali, Radix Angelicae Sinensis are the most accurately weighed,
With flowing steam sterilization, be dried at a temperature of 80 ~ 110 DEG C 5 ~ 10 minutes standby；
(3) step (1) and (2) gained material medicine are pulverized and mix homogeneously, cross No. 6 sieves；Directly play modulus method to rise with powder
Mould, by general for the medicated powder spheroidal particle making diameter 0.8 ~ 1.0mm, sieve takes the granule between a sieve and No. two sieves, obtains ball mould；
(4) step (3) screening gained ball mould is placed in general ball pot, with residue medicated powder and the relative density made of water be 1.32 ~
The slurry of 1.33 is by general for ball mould ball molding, and the rotating speed of general ball pot is 45 turns per minute；
(5) by the pill of molding clear water capping so that it is reach the size criteria of finished product specification, i.e. molding in general ball pot
Pill adds clear water makes molding pill be sufficiently humidified so as to, and rolls in general ball pot, and, color and luster fine and close, bright and clean to pellet surface stops time consistent
Only roll, with microwave drying, sterilizing 5 ~ 10 minutes after taking out rapidly, obtain the moisture pill less than 4wt%；
(6) with vertical inspection ball device, qualified with lopsided pill is separated, collect qualified pill, subpackage, obtain every 100 and weigh about 5
Gram finished product.
Described in the above-mentioned step (3) preparing flashing ball, powder directly plays modulus method molding is common process, i.e. at general ball pot
The a small amount of water of middle sprinkling, is allowed to moistening, dispenses a small amount of medicated powder, rotates general ball pot, brushes the powder of wall attachment of cooking, then sprays water, spreads pesticides
Powder, rotates general ball pot, and repeatedly, by general for the medicated powder spheroidal particle making diameter 0.8 ~ 1.0mm, sieve takes a sieve to such iterative cycles
And the granule between No. two sieves, obtains ball mould；The consumption of molding medicated powder formula routinely calculates: X=0.625 × D/C, in formula, X is
Molding is the dry weight (g) of 100, finished product flashing ball with powder amount (kg), C, and D is medicated powder total amount (kg), and 0.625 is 100 master dies
The weight in wet base (g) of son, it is contained within the moisture of 30% ~ 35%.
By as follows for step that the component of above-mentioned each pharmaceutical composition is prepared as water-honeyed pill:
(1) the most accurately weigh Hirudo crude drug, with pressure cooker (temperature is 120 DEG C) Steam by water bath 30 minutes, dry standby
With；
(2) Radix Salviae Miltiorrhizae, Ganoderma, Radix Notoginseng, Rhizoma Chuanxiong, Flos Carthami, Radix Panacis Quinquefolii, Pheretima, the Radix Astragali, Radix Angelicae Sinensis are the most accurately weighed, with stream
Logical steam sterilization, be dried at a temperature of 80 ~ 110 DEG C 5 ~ 10 minutes standby；
(3) step (1) (2) gained material medicine is pulverized and mix homogeneously, cross No. 6 sieves；Mel is heated to 116 DEG C ~ 118
DEG C, making water content is 14% ~ 16%, and relative density is the refined honey of 1.337, in refined honey: the ratio of water=1:2.5 ~ 3.0 is to refined honey
In add water, stir evenly, boil, filter, prepare mulse；Diameter 0.8 ~ 1.0mm is made with above-mentioned mulse by general for medicated powder in general ball pot
Spheroidal particle, sieve take No. one sieve with No. two sieve between granule, obtain ball mould；
(4) by step (3) screening gained ball mould be placed in general ball pot rotation, on ball mould with mulse moistening ball mould, spread pesticides powder,
Being repeated, until molding, reach the size criteria that finished product specifies, refined honey used by the every 100 grams of medicated powder of molding water-honeyed pill is 40 grams；
(5) with microwave drying, sterilizing 5 ~ 10 minutes, obtain the moisture pill less than 10%；
(6) with vertical inspection ball device, qualified with lopsided pill is separated, collect qualified pill, subpackage, obtain every 100 and weigh about 6
Gram finished product.
In the above-mentioned method preparing water-honeyed pill, the general preparation method in step (3) is common process, with the general preparation method of flashing ball, only
Being to replace water with mulse, i.e. spray a small amount of water in general ball pot, be allowed to moistening, dispense a small amount of medicated powder, rotating general ball pot, brush is cooked
The powder of wall attachment, then sprays mulse, and spread pesticides powder, rotates general ball pot, such iterative cycles repeatedly, by general for medicated powder make diameter 0.8 ~
The spheroidal particle of 1.0mm, sieve takes the granule between a sieve and No. two sieves, obtains ball mould；The consumption of molding medicated powder is the most public
Formula calculates: X=0.625 × D/C, in formula, X is molding powder amount (kg), and C is the dry weight (g) of 100, finished product flashing ball, and D is medicated powder
Total amount (kg), 0.625 is 100 weight (g) of standard mould.
The positive effect of the present invention is:
(1), this drug regimen composition formula reasonable, there is the effect of invigorating qi and benefiting blood, blood circulation promoting and blood stasis dispelling, dredging collateral, vessel softening.To hat
Patient that shape arteriosclerotic heart disease is heavier, that operation risk is big also has preferable curative effect, can not do heart pass art and control
Treat.
(2), the suitable long-term taking of pharmaceutical composition provided by the present invention, have III grade of patient of coronary heart disease function to take this
Invention pharmaceutical composition was checked after 3 years, and clinical symptoms disappears substantially.
(3) method for microwave drying, employed in the preparation method of medicament of the present invention, rate of drying is fast, inside and outside humidity
Uniformly, pill water content is few, produces Swelling Functions and is beneficial to leach, and has the effect of sterilizing.
(4), technical scheme provided by the present invention, low production cost, medical expense cost price for each person every day are used
It is only RMB about 1.2 yuan.When carrying out factorial praluction, technology maturation, profit is big, profitable, has wide development
Prospect.
Detailed description of the invention
In order to make the goal of the invention of the present invention, technical scheme and advantage clearer, below in conjunction with specific embodiment party
The present invention is described in further detail for formula, but this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to following reality
Execute example.
Embodiment 1:
A kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease, it is the medicament made by the material medicine by following weight proportion,
Unit (kg).
Radix Salviae Miltiorrhizae 16, Ganoderma 16, Radix Notoginseng 15, Rhizoma Chuanxiong 14, Flos Carthami 10, Radix Panacis Quinquefolii 8, Hirudo 7, Pheretima 7, the Radix Astragali 5, Radix Angelicae Sinensis 2.
Pharmaceutical composition described in the present embodiment, can be prepared as flashing ball in accordance with the following methods:
(1) " Hirudo " crude drug is the most accurately weighed, with pressure cooker (temperature is 120 DEG C) Steam by water bath 30 minutes, 80 ~
At a temperature of 110 DEG C be dried 5 ~ 10 minutes standby；
(2) Radix Salviae Miltiorrhizae, Ganoderma, Radix Notoginseng, Rhizoma Chuanxiong, Flos Carthami, Radix Panacis Quinquefolii, Pheretima, the Radix Astragali, Radix Angelicae Sinensis are the most accurately weighed, with stream
Logical steam sterilization, be dried at a temperature of 80 ~ 110 DEG C 10 minutes standby；
(3) step (1) (2) gained material medicine is pulverized and mix homogeneously, cross No. 6 sieves；Modulus method molding is directly played with powder.?
General ball pot sprays a small amount of water, is allowed to moistening, dispense a small amount of medicated powder, rotate general ball pot, brush the powder of wall attachment of cooking, then spray
Water, spread pesticides powder, rotates general ball pot, and such iterative cycles repeatedly, by general for the medicated powder spheroidal particle making diameter 0.8 ~ 1.0mm, sieves
Take the granule between a sieve and No. two sieves, obtain ball mould；The consumption of molding medicated powder formula routinely calculates: X=0.625 × D/
C, in formula, X is molding powder amount (kg), and C is the dry weight (g) of 100, finished product flashing ball, and D is medicated powder total amount (kg), and 0.625 is
The weight in wet base (g) of 100 standard mould, it is contained within the moisture of 30% ~ 35%；
(4) step (3) screening gained ball mould is placed in general ball pot, with residue medicated powder and the relative density made of water be 1.32 ~
The slurry of 1.33 is by general for ball mould ball molding, and the rotating speed of general ball pot is 45 turns per minute；
(5) by the pill of molding clear water capping so that it is reach the size criteria of finished product specification, i.e. molding ball in general ball pot
Grain adds clear water makes molding pill be sufficiently humidified so as to, and rolls in general ball pot, stops when, color and luster fine and close, bright and clean to pellet surface is consistent
Roll, with microwave drying, sterilizing 5 ~ 10 minutes after taking out rapidly, obtain the moisture (quality) pill less than 4%；
(6) with vertical inspection ball device, qualified with lopsided pill is separated, collect qualified pill, subpackage, obtain every 100 and weigh about 5
Gram finished product.
Embodiment 2
A kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease, it is the medicament made by the material medicine by following weight proportion,
Unit (kg).
Radix Salviae Miltiorrhizae 10, Ganoderma 10, Radix Notoginseng 9, Rhizoma Chuanxiong 9, Flos Carthami 7, Radix Panacis Quinquefolii 7, Hirudo 6, Pheretima 6, the Radix Astragali 4, Radix Angelicae Sinensis 2.
Pharmaceutical composition described in the present embodiment, can be prepared as water-honeyed pill in accordance with the following methods:
(1) " Hirudo " crude drug is the most accurately weighed, with pressure cooker (temperature is 120 DEG C) Steam by water bath 30 minutes, 80
At a temperature of ~ 110 DEG C be dried 10 minutes standby；
(2) Radix Salviae Miltiorrhizae, Ganoderma, Radix Notoginseng, Rhizoma Chuanxiong, Flos Carthami, Radix Panacis Quinquefolii, Pheretima, the Radix Astragali, Radix Angelicae Sinensis are the most accurately weighed, with stream
Logical steam sterilization, be dried at a temperature of 80 ~ 110 DEG C 5 ~ 10 minutes standby；
(3) step (1) (2) gained material medicine is pulverized and mix homogeneously, cross No. 6 sieves；Mel is heated to 116 DEG C ~ 118
DEG C, making water content is 14% ~ 16%, and relative density is the refined honey of 1.337, in refined honey: the ratio of water=1:2.5 ~ 3.0 is to refined honey
In add water, stir evenly, boil, filter, prepare mulse；Diameter 0.8 ~ 1.0mm is made with above-mentioned mulse by general for medicated powder in general ball pot
Spheroidal particle, sieve take No. one sieve with No. two sieve between granule, obtain ball mould；The consumption of molding medicated powder formula meter routinely
Calculate: X=0.625 × D/C, in formula, X is molding powder amount (kg), and C is the dry weight (g) of 100, finished product flashing ball, and D is medicated powder total amount
(kg), 0.625 is 100 weight (g) of standard mould；
(4) by step (3) screening gained ball mould be placed in general ball pot rotation, on ball mould with mulse moistening ball mould, spread pesticides powder,
Being repeated, until molding, reach the size criteria that finished product specifies, refined honey used by the every 100 grams of medicated powder of molding water-honeyed pill is 40 grams；
(5) with microwave drying, sterilizing 5 ~ 10 minutes, obtain the moisture (quality) pill less than 10%；
(6) with vertical inspection ball device, qualified with lopsided pill is separated, collect qualified pill, subpackage, obtain every 100 and weigh about 6
Gram finished product.
Embodiment 3
A kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease, it is the medicament made by the material medicine by following weight proportion,
Unit (kg).
Radix Salviae Miltiorrhizae 8, Ganoderma 8, Radix Notoginseng 8, Rhizoma Chuanxiong 8, Flos Carthami 5, Radix Panacis Quinquefolii 5, Hirudo 4, Pheretima 4, the Radix Astragali 2, Radix Angelicae Sinensis 1.
Pharmaceutical composition described in the present embodiment, can be prepared as concentrated pill in accordance with the following methods:
(1) the most accurately weigh " Hirudo " crude drug, with Chinese liquor parch " Hirudo " that alcohol concentration is 50% ~ 60%, cause
" Hirudo " color transfers yellow or golden yellow to.Hirudo with the ratio of Chinese liquor is: Hirudo: Chinese liquor=100:5 ~ 10;
(2) Radix Salviae Miltiorrhizae, Ganoderma, Radix Notoginseng, Rhizoma Chuanxiong, Flos Carthami, Radix Panacis Quinquefolii, Pheretima, the Radix Astragali, Radix Angelicae Sinensis are the most accurately weighed, with stream
Logical steam sterilization, be dried at a temperature of 80 ~ 110 DEG C 5 ~ 10 minutes standby；
(3) step (1) (2) gained material medicine is pulverized and mix homogeneously, cross 100 mesh sieves, by above-mentioned powder carbon dioxide
Quench and take the extract of gained and add excipient and make graininess, through screening, dry to moisture (quality) and be not more than 9%, sterilizing,
Subpackage obtains concentrated pill.
Embodiment 4
A kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease, it is the medicament made by the material medicine by following weight proportion,
Unit (kg).
Radix Salviae Miltiorrhizae 14, Ganoderma 14, Radix Notoginseng 13, Rhizoma Chuanxiong 13, Flos Carthami 10, Radix Panacis Quinquefolii 10, Hirudo 6, Pheretima 6, the Radix Astragali 4, Radix Angelicae Sinensis 2.
Pharmaceutical composition described in the present embodiment, can be prepared as tablet in accordance with the following methods:
(1) Hirudo crude drug is the most accurately weighed, with pressure cooker (temperature is 120 DEG C) Steam by water bath 30 minutes, 80 ~
At a temperature of 110 DEG C be dried 10 minutes standby；
(2) Radix Salviae Miltiorrhizae, Ganoderma, Radix Notoginseng, Rhizoma Chuanxiong, Flos Carthami, Radix Panacis Quinquefolii, Pheretima, the Radix Astragali, Radix Angelicae Sinensis are the most accurately weighed, with stream
Logical steam sterilization, be dried at a temperature of 80 ~ 110 DEG C 5 ~ 10 minutes standby；
(3) step (1) (2) gained material medicine is pulverized and mix homogeneously, cross 100 mesh sieves, above-mentioned powder is added excipient system
Piece agent, drying to moisture (quality) is not more than 9%, and sterilizing, subpackage obtains tablet.
Embodiment 5
A kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease, it is the medicament made by the material medicine by following weight proportion,
Unit (kg).
Radix Salviae Miltiorrhizae 18, Ganoderma 18, Radix Notoginseng 16, Rhizoma Chuanxiong 16, Flos Carthami 12, Radix Panacis Quinquefolii 12, Hirudo 8, Pheretima 8, the Radix Astragali 6, Radix Angelicae Sinensis 3.
Pharmaceutical composition described in the present embodiment, can be prepared as capsule in accordance with the following methods:
(1) " Hirudo " crude drug is the most accurately weighed, with pressure cooker (temperature is 120 DEG C) Steam by water bath 30 minutes, 80
At a temperature of ~ 110 DEG C be dried 10 minutes standby；
(2) Radix Salviae Miltiorrhizae, Ganoderma, Radix Notoginseng, Rhizoma Chuanxiong, Flos Carthami, Radix Panacis Quinquefolii, Pheretima, the Radix Astragali, Radix Angelicae Sinensis are the most accurately weighed, with stream
Logical steam sterilization, be dried at a temperature of 80 ~ 110 DEG C 5 ~ 10 minutes standby；
Step (1) and (2) gained material medicine are pulverized and mix homogeneously, crosses 100 mesh sieves, by above-mentioned drying to moisture
(quality) is not more than 9%, and sterilizing, fill capsule, subpackage obtains capsule.
The drug regimen composition formula of the present invention is based on the traditional medicine pathogeny to cardiovascular and cerebrovascular disease (thoracic obstruction, apoplexy)
Understanding and Therapeutic Principle, with reference to modern pharmacology Research Achievement, form by theory of Chinese medical science prescription.Traditional medicine is thought: heart and brain
Angiopathy is owing to improper diet, feelings will are uncomfortable, deficiency of qi and blood, simulataneous insufficiency and excessive, so that QI-blood circulation is obstructed, causes the stagnation of QI, blood
The stasis of blood, stagnation of phlegm, stagnated chest-YANG, stagnating heart meridian, heart spleen caused by liver and kidney deficiency, heart arteries and veins lose supports.When treating cardiovascular and cerebrovascular disease, formula should be followed
Following principle: invigorating qi and benefiting blood, blood circulation promoting and blood stasis dispelling；5 with dredging collateral, the product of vessel softening.Pathological study finds, the master of cardiovascular and cerebrovascular disease
Wanting mechanism is that blood fat increases, and blood viscosity increases, and causes blood vessel wall, especially arterial blood tube wall derivant attachment, forms medicated porridge
Sample dissipating rashes block, sclerosis of blood vessels is narrow, and blood operation is not smooth, even occur blood vessel to block completely.Pharmacology proves, invigorating qi and benefiting blood medicine
Can blood circulation promoting and metabolic function enhancing；Drug for invigorating blood circulation and eliminating stasis can improve microcirculation, suppresses fibroblast rubber polymer
Former, eliminate blood vessel obstruction phenomenon, thus can fully reduce the pathological lesion of disease.Therefore, the pharmaceutical composition of the present invention is with tool
Have invigorating qi and benefiting blood, the Ganoderma of tranquilizing by nourishing the heart and there is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the Radix Salviae Miltiorrhizae of the relieving restlessness that clears away heart-fire are monarch drug, Qi Zhongling
Sesame also has cardiotonic, increases blood flow coronarius, reduces heart oxygen consumption, reduces blood fat, vessel softening and regulation
Blood pressure.With Radix Notoginseng, Rhizoma Chuanxiong, Flos Carthami as ministerial drug, play promoting blood circulation to remove obstruction in the collateral altogether, the merit of eliminating stasis to stop pain；Help and mend with Radix Panacis Quinquefolii, the Radix Astragali, Radix Angelicae Sinensis
Replenishing QI and blood, blood circulation depending on qi flow, strengthen monarch drug invigorating qi and benefiting blood, the effect of blood circulation promoting and blood stasis dispelling；Make with Hirudo, Pheretima, removing blood stasis, work of stimulating the menstrual flow
Network, cleans blood vessel wall.Making a general survey of pharmaceutical composition of the present invention side entirely, compatibility is rigorous, embodies the Therapeutic Principle of the present invention.
For showing the pharmaceutical composition of the present invention therapeutic effect to cardiovascular and cerebrovascular disease, inventor is from inpatient department and the heart
Internal medicine special outpatient clinic select be diagnosed as coronary heart disease, cerebral infarction, brain atrophy, the single disease of apoplexy sequela or two kinds and two kinds with
Patient cases 400 example of upper disease (clinical criteria with reference to Ministry of Health of the People's Republic of China within 1993, promulgate " Chinese medicine is new
Medicine guideline of clinical investigations " diagnostic criteria formulated).It is randomly divided into treatment group, matched group 1, matched group 2 and matched group 3.Control
Each 100 examples for the treatment of group, matched group 1, matched group 2, matched group 3, and medical history, the state of an illness, age, sex are suitable.
Treatment group: coronary atherosclerotic heart disease 20 example, sick 22 examples of lacunar infarction, lacunar local cerebral infarction
Dead companion's cerebral atrophy 23 example, sick 30 examples of coronary atherosclerotic heart disease companion's lacunar infarction, apoplexy sequela 5
Example.
Matched group 1: coronary atherosclerotic heart disease 23 example, sick 22 examples of lacunar infarction, lacunar local cerebral
Infarction companion's brain atrophy 24 example, sick 27 examples of coronary atherosclerotic heart disease companion's lacunar infarction, apoplexy sequela 4 example
Matched group 2: coronary atherosclerotic heart disease 25 example, sick 20 examples of lacunar infarction, lacunar local cerebral infarction
Companion's brain atrophy 21 example, sick 31 examples of coronary atherosclerotic heart disease companion's lacunar infarction, apoplexy sequela 3 example.
Matched group 3: coronary atherosclerotic heart disease 23 example, sick 25 examples of lacunar infarction, lacunar local cerebral
Infarction companion's brain atrophy 22 example, sick 26 examples of coronary atherosclerotic heart disease companion's lacunar infarction, apoplexy sequela 4 example
Treatment group uses by the raw material in embodiment 1 and preparation method, it is ensured that the flashing ball made in the case of parameter constant.Control
Treatment group, with above-mentioned flashing ball, is swallowed by warm water after meal half an hour, every day 3g, three times on the one.
Matched group 1 is also adopted by the raw material in embodiment 1 and preparation method, only changes the flashing that the process step of Hirudo is made
Ball.
The process step of Hirudo changes to: the most accurately weigh " Hirudo " crude drug, with alcohol concentration be 50% ~
The Chinese liquor parch " Hirudo " of 60%, causes " Hirudo " color and transfers yellow or golden yellow to.Hirudo with the ratio of Chinese liquor is: Hirudo:
Chinese liquor=100:5 ~ 10.
Matched group 1, with above-mentioned flashing ball, is swallowed by warm water after meal half an hour, every day 3g, three times on the one.
The raw material that matched group 2 uses is consistent with embodiment 1, and its preparation method is also consistent with embodiment 1, but only changes
The addition of Flos Carthami, the addition of Flos Carthami changes to 40 under similarity condition.
Matched group 2, with above-mentioned flashing ball, is swallowed by warm water after meal half an hour, every day 3g, three times on the one.
Matched group 3 Western medicine: Plavix 75mg/1 sheet, once a day；Aspirin 100mg/1 sheet, once a day；Chlorination
Potassium sustained release tablets 1000mg/2 sheet, twice daily；Atropic atorvastatin calcium tablet 20mg/1 sheet, the most once；Trimetazidine Hydrochloride Tablets in healthy
20mg/1 sheet, once a day；Spironolactone Tablets 20mg/1 sheet, once a day.
Require that patient takes a good rest, less salt low fat diet, smoking cessation, it is to avoid fatigue is suffered from cold.Within 30 days, it is a course for the treatment of, observes 3 treatments
Journey.
Clinical test results (curative effect determinate standard with reference to Ministry of Health of the People's Republic of China within 1993, issue " Chinese medicine is new
Medicine guideline of clinical investigations " standard formulated): treatment group is fully recovered 26 examples, effective 68 examples, invalid 6 examples, and cure rate 26% always has
Efficiency 94%；Matched group 1 is fully recovered 18 examples, effective 62 examples, invalid 20 examples, cure rate 18%, total effective rate 80；Matched group 2 fully recovers 16
Example, effective 61 examples, invalid 23 examples, cure rate 16%, total effective rate 77%；Matched group 3 is fully recovered 12 examples, effective 66 examples, invalid 22 examples,
Cure rate 12%, total effective rate 78%.Clinical test results shows that the curative effect of medicine composite for curing cardiovascular and cerebrovascular disease of the present invention shows
Write.Wherein in matched group 2 formula, crude drug " Flos Carthami " ratio is 4%, crude drug " Flos Carthami " in the formula that the technical program provides
Minimum ratio is 5%.In the case of preparation technology is identical, it is notable that matched group 2 compares Different therapeutical effect with treatment group.This
Relatively also demonstrate the maturity of the technical program, as adjusted the minimum ratio of other drug in the technical program formula, all can
Cause curative effect reduction in various degree.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Any amendment, equivalent and the improvement etc. made within god and principle, should be included within the scope of the present invention.
Claims (7)
1. the pharmaceutical composition treating cardiovascular and cerebrovascular disease, it is characterised in that it is by the material medicine of following weight proportioning
Made medicament:
Radix Salviae Miltiorrhizae 80 ~ 200, Ganoderma 80 ~ 200, Radix Notoginseng 80 ~ 180, Rhizoma Chuanxiong 80 ~ 180, Flos Carthami 50 ~ 150, Radix Panacis Quinquefolii 50 ~ 150, Hirudo
40 ~ 100, Pheretima 40 ~ 100, the Radix Astragali 20 ~ 80, Radix Angelicae Sinensis 10 ~ 40.
Treat the pharmaceutical composition of cardiovascular and cerebrovascular disease the most according to claim 1, it is characterised in that the weight of each material medicine
Proportioning is:
Radix Salviae Miltiorrhizae 100 ~ 180, Ganoderma 100 ~ 180, Radix Notoginseng 100 ~ 160, Rhizoma Chuanxiong 100 ~ 160, Flos Carthami 70 ~ 170, Radix Panacis Quinquefolii 70 ~ 120,
Hirudo 60 ~ 80, Pheretima 60 ~ 80, the Radix Astragali 40 ~ 60, Radix Angelicae Sinensis 20 ~ 30.
Treat the pharmaceutical composition of cardiovascular and cerebrovascular disease the most according to claim 1, it is characterised in that the weight of each material medicine
Proportioning is:
Radix Salviae Miltiorrhizae 160, Ganoderma 160, Radix Notoginseng 150, Rhizoma Chuanxiong 140, Flos Carthami 100, Radix Panacis Quinquefolii 80, Hirudo 70, Pheretima 70, the Radix Astragali 50, when
Return 20.
4. according to the pharmaceutical composition treating cardiovascular and cerebrovascular disease according to any one of claim 1 ~ 3, it is characterised in that: described medicine
Agent is flashing ball or water-honeyed pill.
Treat the pharmaceutical composition of cardiovascular and cerebrovascular disease the most according to claim 1, it is characterised in that: described Hirudo is for using
Hirudo crude drug, standby by pressure cooker 30 minutes post-dryings of Steam by water bath at a temperature of 120 DEG C.
6. described in any one claim in claim 1-5, treat the preparation side of the pharmaceutical composition of cardiovascular and cerebrovascular disease
Method, it is characterised in that the preparation method of flashing ball comprises the steps:
(1) Hirudo crude drug is the most accurately weighed, with pressure cooker Steam by water bath 30 minutes at a temperature of 120 DEG C, 80 ~
At a temperature of 110 DEG C be dried 5 ~ 10 minutes standby；
(2) Radix Salviae Miltiorrhizae, Ganoderma, Radix Notoginseng, Rhizoma Chuanxiong, Flos Carthami, Radix Panacis Quinquefolii, Pheretima, the Radix Astragali, Radix Angelicae Sinensis are the most accurately weighed, with stream
Logical steam sterilization, be dried at a temperature of 80 ~ 110 DEG C 5 ~ 10 minutes standby；
(3) step (1) and (2) gained material medicine are pulverized and mix homogeneously, cross No. 6 sieves；Modulus method molding is directly played with powder,
By general for the medicated powder spheroidal particle making diameter 0.8 ~ 1.0mm, sieve takes the granule between a sieve and No. two sieves, obtains ball mould；
(4) step (3) screening gained ball mould is placed in general ball pot, with residue medicated powder and the relative density made of water be 1.32 ~
The slurry of 1.33 is by general for ball mould ball molding, and the rotating speed of general ball pot is 45 turns per minute；
(5) by the pill of molding clear water capping so that it is reach the size criteria of finished product specification, i.e. molding ball in general ball pot
Grain adds clear water makes molding pill be sufficiently humidified so as to, and rolls in general ball pot, stops when, color and luster fine and close, bright and clean to pellet surface is consistent
Roll, with microwave drying, sterilizing 5 ~ 10 minutes after taking out rapidly, obtain the moisture pill less than 4wt%；
(6) with vertical inspection ball device, qualified with lopsided pill is separated, collect qualified pill, subpackage, obtain every 100 and weigh about 5
Gram finished product.
7. treat the preparation method of the pharmaceutical composition of cardiovascular and cerebrovascular disease described in claim 1-5, it is characterised in that water-honeyed pill
Preparation method comprise the steps:
(1) Hirudo crude drug is the most accurately weighed, with pressure cooker Steam by water bath 30 minutes at a temperature of 120 DEG C, 80 ~
At a temperature of 110 DEG C be dried 5 ~ 10 minutes standby；
(2) Radix Salviae Miltiorrhizae, Ganoderma, Radix Notoginseng, Rhizoma Chuanxiong, Flos Carthami, Radix Panacis Quinquefolii, Pheretima, the Radix Astragali, Radix Angelicae Sinensis are the most accurately weighed, with stream
Logical steam sterilization, be dried at a temperature of 80 ~ 110 DEG C 5 ~ 10 minutes standby；
(3) step (1) (2) gained material medicine is pulverized and mix homogeneously, cross No. 6 sieves；Mel is heated to 116 DEG C ~ 118
DEG C, making water content is 14wt% ~ 16wt%, and relative density is the refined honey of 1.337, by refined honey: mass ratio=1:2.5 ~ 3.0 of water
Ratio add water in refined honey, stir evenly, boil, filter, prepare mulse；General ball pot is made general for medicated powder directly with above-mentioned mulse
The spheroidal particle of footpath 0.8 ~ 1.0mm, sieve takes the granule between a sieve and No. two sieves, obtains ball mould；
(4) by step (3) screening gained ball mould be placed in general ball pot rotation, on ball mould with mulse moistening ball mould, spread pesticides powder, instead
Carrying out again, until molding, reach the size criteria that finished product specifies, refined honey used by the every 100 grams of medicated powder of molding water-honeyed pill is 40 grams；
(5) with microwave drying, sterilizing 5 ~ 10 minutes, obtain the moisture pill less than 10wt%；
(6) with vertical inspection ball device, qualified with lopsided pill is separated, collect qualified pill, subpackage, obtain every 100 and weigh about 6
Gram finished product.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107551139A (en) * | 2017-09-30 | 2018-01-09 | 苑学 | A kind of combined traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases |
| CN111714589A (en) * | 2020-08-13 | 2020-09-29 | 河南中医药大学 | Traditional Chinese medicine composition and traditional Chinese medicine preparation for resisting atherosclerosis |
| CN114869944A (en) * | 2022-04-25 | 2022-08-09 | 广东药科大学 | Traditional Chinese medicine composition for treating atherosclerosis and preparation method thereof |
| CN116898907A (en) * | 2023-08-28 | 2023-10-20 | 陕西铭瑞堂医疗管理有限公司 | Formula and method for preventing and treating cardiovascular and cerebrovascular diseases caused by blood stasis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225100A (en) * | 2011-06-04 | 2011-10-26 | 李现华 | Chinese medicinal formulation for treating cardiovascular and cerebrovascular diseases and preparation process of products thereof |
-
2016
- 2016-09-21 CN CN201610836474.9A patent/CN106236833A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225100A (en) * | 2011-06-04 | 2011-10-26 | 李现华 | Chinese medicinal formulation for treating cardiovascular and cerebrovascular diseases and preparation process of products thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107551139A (en) * | 2017-09-30 | 2018-01-09 | 苑学 | A kind of combined traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases |
| CN111714589A (en) * | 2020-08-13 | 2020-09-29 | 河南中医药大学 | Traditional Chinese medicine composition and traditional Chinese medicine preparation for resisting atherosclerosis |
| CN111714589B (en) * | 2020-08-13 | 2022-09-06 | 河南中医药大学 | Traditional Chinese medicine composition and traditional Chinese medicine preparation for resisting atherosclerosis |
| CN114869944A (en) * | 2022-04-25 | 2022-08-09 | 广东药科大学 | Traditional Chinese medicine composition for treating atherosclerosis and preparation method thereof |
| CN114869944B (en) * | 2022-04-25 | 2023-06-06 | 广东药科大学 | Traditional Chinese medicine composition for treating atherosclerosis and preparation method thereof |
| CN116898907A (en) * | 2023-08-28 | 2023-10-20 | 陕西铭瑞堂医疗管理有限公司 | Formula and method for preventing and treating cardiovascular and cerebrovascular diseases caused by blood stasis |
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