CN106232030B

CN106232030B - The method of implantable layer and the shape for modifying the implantable layer being used together with reuse surgical fasteners tool

Info

Publication number: CN106232030B
Application number: CN201580020848.3A
Authority: CN
Inventors: M·J·文德利; M·D·蒂默; J·J·唐纳斯; D·L·雷诺兹二世; T·W·阿伦霍尔特; T·J·巴顿
Original assignee: Ethicon Endo Surgery Inc
Current assignee: Ethicon Endo Surgery Inc
Priority date: 2014-02-24
Filing date: 2015-02-10
Publication date: 2019-02-12
Anticipated expiration: 2035-02-10
Also published as: BR112016019360B1; RU2016137895A; MX2016010958A; CA2940512A1; CA2940512C; RU2016137895A3; JP6538089B2; CN106232030A; BR112016019360A2; AU2015219354A1; JP2017509456A; AU2015219354B2; RU2689766C2

Abstract

The invention discloses a kind of methods for changing the implantable layer being used together with surgical instruments, it the described method comprises the following steps: obtaining implantable layer, the implantable layer is at least partly by including that the material of glass transition temperature and melting temperature is constituted, wherein the implantable layer has first shape；The material is heated to above the glass transition temperature and is lower than the temperature of the melting temperature；The implantable layer is manipulated to the second shape different from the first shape；The material is set to be cool below the glass transition temperature；And the release implantable layer.

Description

It can plant layer and for modifying the implantable layer being used together with reuse surgical fasteners tool The method of shape

Background technique

The present invention relates to surgical instruments, and in various arrangements, are related to the surgery for being designed to suture and cut tissue Suture and cutting device and its nail bin.

Detailed description of the invention

Refer to the following explanation of embodiment of the present invention, the features and advantages of the present invention and realization in conjunction with the accompanying drawings The mode of these feature and advantage will become more apparent, and be better understood invention itself, in which:

Fig. 1 is the front, left perspective view of the surgical stapling with handle portions and cutting off apparatus；

Fig. 2 is the perspective view of the surgical stapling of Fig. 1 and the split type knife and trigger shaft (" e-beam ") of cutting off apparatus；

Fig. 3 is the perspective view of the wedge-shaped slides of the nail bin of nail administration assembly；

Fig. 4 is the longitudinal sectional drawing of nail bin and anvil block in the close position, which includes rigid support portion and can Tissue thickness compensation part is compressed, showing nail, never firing position moves to firing position during First ray；

Fig. 5 is the anvil block of Fig. 4 and another sectional view of nail bin, is shown in an open position after completing percussion sequence Anvil block；

Fig. 6 is the decomposition perspective view of tissue thickness compensation part and nail bin groupware；

Fig. 7 is the partial sectional view of the nail bin groupware of Fig. 6, shows in the nail cavity for being located in staple cartridge body and is partially submerged into tissue The nail not fired in thickness compensation part；

Fig. 8 is the partial sectional view of the nail bin groupware of Fig. 6, shows and projects from the nail cavity of staple cartridge body and against anvil block forming The nail of percussion, and the tissue of tissue thickness compensation part and capture in the nail retention region of nail formed thereby is further shown；

Fig. 9 is the local perspective view of the end effector of reuse surgical fasteners tool, and some of parts remove and show, and Other parts are illustrated in cross-section；In addition, the cutting element of end effector, which is shown in part, promotes position；

Figure 10 is the part section end-view of the end effector of Fig. 9, and there is shown with patient tissue captures to execute in end Between the anvil block and tissue thickness compensation part of device；In addition, the intracorporal nail in the storehouse for being removedly stored in end effector is illustrated as Cutting element in non-firing position and end effector, which is shown in, does not promote position close to tissue thickness compensation part It sets；

Figure 11 is the part section end-view of the end effector of Fig. 9, and there is shown with nails in firing position and to cut Component is in part and promotes position, and wherein patient tissue is by least partly crosscutting；

Figure 12 is the part section end-view of the end effector of Fig. 9, and there is shown with nails in firing position and to cut Component, which is in, promotes position, and wherein at least part of tissue thickness compensation part is crosscutting by cutting element；

Figure 13 be include tissue thickness compensation part fastener cartridge perspective view；

Figure 14 is the cross-sectional view of the tissue thickness compensation part of Figure 13, shows the proximal end relative to tissue thickness compensation part The cutting element of positioning；

Figure 15 is the exploded view of tissue thickness compensation part component；

Figure 16 is the perspective view of tissue thickness compensation part component layer；

Figure 17 is the cross-sectional view of the tissue thickness compensation part component of Figure 15；

Figure 18 is the tissue thickness compensation part component of assembling and the sectional perspective view for assembling its mold；

Figure 19 is the perspective view of the tissue thickness compensation part component of the assembling of Figure 18；

Figure 20 is tissue thickness compensation part component and the perspective view for assembling its mold；

Figure 21 is tissue thickness compensation part component and the perspective view for assembling its mold；

The sectional perspective view of the mold for assembling it of tissue thickness compensation part component and Figure 21 that Figure 22 is Figure 21；

Figure 23 be include tissue thickness compensation part end effector perspective view；

End effector and tissue thickness compensation part that Figure 24 is Figure 23 and the modification structure for modifying tissue thickness compensation part The perspective view of part；

Figure 25 is the perspective view of the end effector of the tissue thickness compensation part of the modification including Figure 24 of Figure 23；

Figure 26 is the sectional perspective view of tissue thickness compensation part；

Figure 27 is the sectional perspective view for modifying the mold of the tissue thickness compensation part of Figure 26；

Figure 28 is Figure 26 in the sectional perspective view by the tissue thickness compensation part after the modification of the mold of Figure 27；

Figure 29 is the sectional perspective view of tissue thickness compensation part；

Figure 30 is the sectional perspective view for modifying the mold of the tissue thickness compensation part of Figure 29；

Figure 31 is Figure 29 in the sectional perspective view by the tissue thickness compensation part after the modification of the mold of Figure 30；

Figure 32 is the sectional perspective view of tissue thickness compensation part；

Figure 33 is the sectional perspective view for modifying the mold of the tissue thickness compensation part of Figure 32；

Figure 34 is Figure 32 in the sectional perspective view by the tissue thickness compensation part after the modification of the mold of Figure 33；

Figure 35 be include the first height tissue thickness compensation part sectional perspective view；

Figure 36 be Figure 35 modification with the section for the tissue thickness compensation part that the first Level Change is the second height is saturating View；

Figure 37 is the cross-sectional view for modifying the mold of the tissue thickness compensation part of Figure 35；

Figure 38 is the sectional perspective view of tissue thickness compensation part；

Figure 39 is the sectional perspective view of the tissue thickness compensation part after modification of Figure 38；

Figure 40 is the curve graph for showing influence of the compressing force to the flexible ratio of tissue thickness compensation part；

Figure 41 is the sectional perspective view of tissue thickness compensation part；

Figure 42 is the sectional perspective view for modifying the space creator of the tissue thickness compensation part of Figure 41；

Figure 43 is Figure 41 in the sectional perspective view by the tissue thickness compensation part after the modification of the space creator of Figure 42；

The fastener of at least one embodiment being used together with the surgical instruments for including firing member according to Figure 44 The broken section front view in storehouse, part are removed and are shown；

Figure 45 is broken section front view, and the tissue thickness for showing the fastener cartridge of the Figure 44 just removed from fastener cartridge is mended Repay part and the firing member for being shown as the Figure 44 being in the lock state；

Figure 46 is the local perspective view of the tissue thickness compensation part of Figure 45；

The local perspective view of the tissue thickness compensation part of at least one embodiment according to Figure 47；

Figure 48 is to include the fastener cartridge of tissue thickness compensation part with Figure 47, sliding part and supported by sliding part The broken section front view of the end effector of the surgical instruments of firing member, part are removed and are shown；

Figure 49 is the broken section front view of the end effector of Figure 48, shows the percussion structure in part firing position Part；

Figure 50 is the broken section front view of the end effector of Figure 48, shows the tissue thickness removed from fastener cartridge and mends Firing member in repaying part and being in the lock state；

The local perspective view of the fastener cartridge of at least one embodiment according to Figure 51, part are removed and are shown；

Figure 52 is the perspective view of the sliding part of the fastener cartridge of Figure 51；

Figure 53 is the local perspective view of the fastener cartridge of Figure 51；

The front view of the sliding part of at least one embodiment according to Figure 54；

The perspective view of the sliding part for being shown in unlocked configurations of at least one embodiment according to Figure 55；

Figure 56 is the perspective view of the sliding part for being shown in locked configuration of Figure 55；

Figure 57 is the broken section front view for the sliding part of Figure 55 being located in fastener cartridge, is shown unlocked in its The sliding part of configuration, the firing member supported by sliding part, and the tissue thickness of fastener cartridge engage with sliding part compensate Part；

The broken section front view for the tissue thickness compensation part just removed from the fastener cartridge of Figure 57 that Figure 58 is Figure 57, should The sliding part of Figure 55 is placed in its locked configuration and the firing member of Figure 57 is placed in lock state by fastener cartridge；

The part for the sliding part of at least one embodiment being located at the proximal end of fastener cartridge according to Figure 59 Sectional front view, part are removed and are shown；

Figure 60 is the broken section front view for the sliding part of Figure 59 being shown at the distal end of fastener cartridge；

Figure 61 is the perspective view according to the sliding part of at least one embodiment；

Figure 62 is the diagram for showing the nail including multiple barbs according at least one embodiment, wherein nail is illustrated as locating In unshaped configuration and deformed configuration；

The front view of the nail including multiple barbs of at least one embodiment according to Figure 63, wherein nail is located in In the nail cavity of non-firing position；

The front view of the nail including multiple barbs of at least one embodiment according to Figure 64；

The front view of the nail including multiple barbs of at least one embodiment according to Figure 65；

The front view of the nail including multiple barbs of at least one embodiment according to Figure 66；

The front view of the nail including multiple barbs of at least one embodiment according to Figure 67；

The front view of the nail including multiple barbs of at least one embodiment according to Figure 68, wherein nail is located in In the nail cavity of non-firing position；

Figure 69 is the nail of Figure 68 and the plan view of nail cavity；

The local perspective view of the nail leg with barb of at least one embodiment according to Figure 70；

Figure 71 is the local perspective view of the nail leg with barb of the nail of Figure 68；

Figure 71 A is the sectional plain-view drawing of the nail leg with barb of Figure 71；

The local perspective view of the nail leg with barb of at least one embodiment according to Figure 72；And

The local perspective view of the nail leg with barb of at least one embodiment according to Figure 73.

Specific embodiment

Present applicant also possesses the U.S. Patent application of following identification, these U.S. Patent applications are respectively with reference Mode is respectively integrally incorporated herein:

The U.S. of entitled " SURGICAL INSTRUMENTS WITH RECONFIGURABLE SHAFT SEGMENTS " Patent application serial number 12/894,311 (being now U.S. Patent Publication 2012/0080496)；

Entitled " SURGICAL STAPLE CARTRIDGES SUPPORTING NON-LINEARLY ARRANGED STAPLES AND SURGICAL STAPLING INSTRUMENTS WITH COMMON STAPLE-FORMING POCKETS” U.S. Patent Application Serial Number 12/894,340 (being now U.S. Patent Publication 2012/0080482)；

The United States Patent (USP) Shen of entitled " JAW CLOSURE ARRANGEMENTS FOR SURGICAL INSTRUMENTS " It please sequence number 12/894,327 (being now U.S. Patent Publication 2012/0080499)；

Entitled " SURGICAL CUTTING AND FASTENING INSTRUMENTS WITH SEPARATE AND The U.S. Patent Application Serial Number of DISTINCT FASTENER DEPLOYMENT AND TISSUE CUTTING SYSTEMS " 12/894,351 (being now U.S. Patent Publication 2012/0080502)；

Entitled " IMPLANTABLE FASTENER CARTRIDGE HAVING A NON-UNIFORM The U.S. Patent Application Serial Number 12/894,338 (being now U.S. Patent Publication 2012/0080481) of ARRANGEMENT "；

Entitled " IMPLANTABLE FASTENER CARTRIDGE COMPRISING ASUPPORT RETAINER's " U.S. Patent Application Serial Number 12/894,369 (being now U.S. Patent Publication 2012/0080344)；

The beauty of entitled " IMPLANTABLE FASTENER CARTRIDGE COMPRISING MULTIPLE LAYERS " State's patent application serial number 12/894,312 (being now U.S. Patent Publication 2012/0080479)；

The U.S. of entitled " SELECTIVELY ORIENTABLE IMPLANTABLE FASTENER CARTRIDGE " is special Sharp patent application serial numbers 12/894,377 (being now United States Patent (USP) 8,393,514)；

Entitled " SURGICAL STAPLING INSTRUMENT WITH COMPACT ARTICULATION CONTROL The U.S. Patent Application Serial Number 12/894,339 (being now U.S. Patent Publication 2012/0080500) of ARRANGEMENT "；

Entitled " SURGICAL STAPLING INSTRUMENT WITH A VARIABLE STAPLE FORMING The U.S. Patent Application Serial Number 12/894,360 (being now U.S. Patent Publication 2012/0080484) of SYSTEM "；

Entitled " SURGICAL STAPLING INSTRUMENT WITH INTERCHANGEABLE STAPLE The U.S. Patent Application Serial Number 12/894,322 of CARTRIDGE ARRANGEMENTS " (is now U.S. Patent Publication 2012/ 0080501)；

Entitled " SURGICAL STAPLE CARTRIDGES WITH DETACHABLE SUPPORT STRUCTURES " U.S. Patent Application Serial Number 12/894,350 (being now U.S. Patent Publication 2012/0080478)；

Entitled " IMPLANTABLE FASTENER CARTRIDGE COMPRISING BIOABSORBABLE The U.S. Patent Application Serial Number 12/894,383 (being now U.S. Patent Publication 2012/0080345) of LAYERS "；

The U.S. Patent Application Serial Number 12/894,389 of entitled " COMPRESSIBLE FASTENER CARTRIDGE " (being now U.S. Patent Publication 2012/0080335)；

The United States Patent (USP) of entitled " FASTENERS SUPPORTED BY A FASTENER CARTRIDGE SUPPORT " Patent application serial numbers 12/894,345 (being now U.S. Patent Publication 2012/0080483)；

The U.S. Patent Application Serial Number 12/894,306 of entitled " COLLAPSIBLE FASTENER CARTRIDGE " (being now U.S. Patent Publication 2012/0080332)；

Entitled " FASTENER SYSTEM COMPRISING A PLURALITY OF CONNECTED RETENTION The U.S. Patent Application Serial Number 12/894,318 (being now U.S. Patent Publication 2012/0080480) of MATRIX ELEMENTS "；

Entitled " FASTENER SYSTEM COMPRISING A RETENTION MATRIX AND AN ALIGNMENT The U.S. Patent Application Serial Number 12/894,330 (being now U.S. Patent Publication 2012/0080503) of MATRIX "；

The U.S. Patent application sequence of entitled " FASTENER SYSTEM COMPRISING A RETENTION MATRIX " Row number 12/894,361 (being now United States Patent (USP) 8,529,600)；

Entitled " FASTENING INSTRUMENT FOR DEPLOYING A FASTENER SYSTEM The U.S. Patent Application Serial Number 12/894,367 of COMPRISING A RETENTION MATRIX " (is now U.S. Patent Publication 2012/0080485)；

The beauty of entitled " FASTENER SYSTEM COMPRISING A RETENTION MATRIX AND A COVER " State's patent application serial number 12/894,388 (being now United States Patent (USP) 8,474,677)；

Entitled " FASTENER SYSTEM COMPRISING A PLURALITY OF FASTENER CARTRIDGES " U.S. Patent Application Serial Number 12/894,376 (being now U.S. Patent Publication 2012/0080486)；

Entitled " SURGICAL STAPLER ANVIL COMPRISING A PLURALITY OF FORMING The U.S. Patent Application Serial Number 13/097,865 (being now U.S. Patent Publication 2012/0080488) of POCKETS "；

The United States Patent (USP) of entitled " TISSUE THICKNESS COMPENSATOR FOR A SURGICAL STAPLER " Patent application serial numbers 13/097,936 (being now U.S. Patent Publication 2012/0080339)；

Entitled " STAPLE CARTRIDGE COMPRISING A VARIABLE THICKNESS COMPRESSIBLE The U.S. Patent Application Serial Number 13/097,954 (being now U.S. Patent Publication 2012/0080340) of PORTION "；

Entitled " STAPLE CARTRIDGE COMPRISING STAPLES POSITIONED WITHIN A The U.S. Patent Application Serial Number 13/097,856 of COMPRESSIBLE PORTION THEREOF " (is now U.S. Patent Publication 2012/0080336)；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING DETACHABLE PORTIONS's " U.S. Patent Application Serial Number 13/097,928 (being now U.S. Patent Publication 2012/0080490)；

Entitled " TISSUE THICKNESS COMPENSATOR FOR A SURGICAL STAPLER COMPRISING The U.S. Patent Application Serial Number 13/097,891 of AN ADJUSTABLE ANVIL " (is now U.S. Patent Publication 2012/ 0080489)；

The beauty of entitled " STAPLE CARTRIDGE COMPRISING AN ADJUSTABLE DISTAL PORTION " State's patent application serial number 13/097,948 (being now U.S. Patent Publication 2012/0083836)；

The U.S. Patent Application Serial Number 13/ of entitled " COMPRESSIBLE STAPLE CARTRIDGE ASSEMBLY " 097,907 (being now U.S. Patent Publication 2012/0080338)；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING PORTIONS HAVING The U.S. Patent Application Serial Number 13/097,861 of DIFFERENT PROPERTIES " (is now U.S. Patent Publication 2012/ 0080337)；

The U.S. Patent Application Serial Number 13/097 of entitled " STAPLE CARTRIDGE LOADING ASSEMBLY ", 869 (being now U.S. Patent Publication 2012/0160721)；

Entitled " COMPRESSIBLE STAPLE CARTRIDGE COMPRISING ALIGNMENT MEMBERS's " U.S. Patent Application Serial Number 13/097,917 (being now U.S. Patent Publication 2012/0083834)；

The United States Patent (USP) Shen of entitled " STAPLE CARTRIDGE COMPRISING A RELEASABLE PORTION " It please sequence number 13/097,873 (being now U.S. Patent Publication 2012/0083833)；

Entitled " STAPLE CARTRIDGE COMPRISING COMPRESSIBLE DISTORTION RESISTANT The U.S. Patent Application Serial Number 13/097,938 (being now U.S. Patent Publication 2012/0080491) of COMPONENTS "；

Entitled " STAPLE CARTRIDGE COMPRISING A TISSUE THICKNESS COMPENSATOR's " U.S. Patent Application Serial Number 13/097,924 (being now U.S. Patent Publication 2012/0083835)；

The U.S. Patent Application Serial Number 13/ of entitled " SURGICAL STAPLER WITH FLOATING ANVIL " 242,029 (being now U.S. Patent Publication 2012/0080493)；

The U.S. Patent application sequence of entitled " CURVED END EFFECTOR FOR A STAPLING INSTRUMENT " Row number 13/242,066 (being now U.S. Patent Publication 2012/0080498)；

The U.S. Patent Application Serial of entitled " STAPLE CARTRIDGE INCLUDING COLLAPSIBLE DECK " Number 13/242,086 (being now U.S. Patent Publication 2013/0075450)；

The U.S. of entitled " STAPLE CARTRIDGE INCLUDING COLLAPSIBLE DECK ARRANGEMENT " Patent application serial number 13/241,912 (being now U.S. Patent Publication 2013/0075448)；

The U.S. Patent application of entitled " SURGICAL STAPLER WITH STATIONARY STAPLE DRIVERS " Sequence number 13/241,922 (being now U.S. Patent Publication 2013/0075449)；

Entitled " SURGICAL INSTRUMENT WITH TRIGGER ASSEMBLY FOR GENERATING The U.S. Patent Application Serial Number 13/241,637 of MULTIPLE ACTUATION MOTIONS " (is now U.S. Patent Publication 2012/0074201)；

Entitled " SURGICAL INSTRUMENT WITH SELECTIVELY ARTICULATABLE END The U.S. Patent Application Serial Number 13/241,629 (being now U.S. Patent Publication 2012/0074200) of EFFECTOR "；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING A PLURALITY OF The U.S. Patent Application Serial Number 13/433,096 (being now U.S. Patent Publication 2012/0241496) of CAPSULES "；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING A PLURALITY OF LAYERS " U.S. Patent Application Serial Number 13/433,103 (being now U.S. Patent Publication 2012/0241498)；

The U.S. Patent Application Serial Number of entitled " EXPANDABLE TISSUE THICKNESS COMPENSATOR " 13/433,098 (being now U.S. Patent Publication 2012/0241491)；

The United States Patent (USP) of entitled " TISSUE THICKNESS COMPENSATOR COMPRISING A RESERVOIR " Patent application serial numbers 13/433,102 (being now U.S. Patent Publication 2012/0241497)；

Entitled " RETAINER ASSEMBLY INCLUDING A TISSUE THICKNESS COMPENSATOR's " U.S. Patent Application Serial Number 13/433,114 (being now U.S. Patent Publication 2012/0241499)；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING ATLEAST ONE The U.S. Patent Application Serial Number 13/433,136 (being now U.S. Patent Publication 2012/0241492) of MEDICAMENT "；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING CONTROLLED RELEASE AND The U.S. Patent Application Serial Number 13/433,141 (being now U.S. Patent Publication 2012/0241493) of EXPANSION "；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING FIBERS TO PRODUCE A The U.S. Patent Application Serial Number 13/433,144 (being now U.S. Patent Publication 2012/0241500) of RESILIENT LOAD "；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING STRUCTURE TO PRODUCE A The U.S. Patent Application Serial Number 13/433,148 (being now U.S. Patent Publication 2012/0241501) of RESILIENT LOAD "；

The beauty of entitled " TISSUE THICKNESS COMPENSATOR COMPRISING RESILIENT MEMBERS " State's patent application serial number 13/433,155 (being now U.S. Patent Publication 2012/0241502)；

Entitled " METHODS FOR FORMING TISSUE THICKNESS COMPENSATOR ARRANGEMENTS The U.S. Patent Application Serial Number 13/433,163 of FOR SURGICAL STAPLERS " (is now U.S. Patent Publication 2012/ 0248169)；

The U.S. Patent Application Serial Number 13/433,167 of entitled " TISSUE THICKNESS COMPENSATORS " (being now U.S. Patent Publication 2012/0241503)；

The U.S. Patent Application Serial Number 13/ of entitled " LAYERED TISSUE THICKNESS COMPENSATOR " 433,175 (being now U.S. Patent Publication 2012/0253298)；

Entitled " TISSUE THICKNESS COMPENSATORS FOR CIRCULAR SURGICAL STAPLERS " U.S. Patent Application Serial Number 13/433,179 (being now U.S. Patent Publication 2012/0241505)；

The U.S. Patent Application Serial Number 13/763,028 of entitled " ADHESIVE FILM LAMINATE " (is now the U.S. Patent disclosure 2013/0146643)；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING CAPSULES DEFINING A The U.S. Patent Application Serial Number 13/433,115 of LOW PRESSURE ENVIRONMENT " (is now U.S. Patent Publication 2013/ 0256372)；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISED OF A PLURALITY OF The U.S. Patent Application Serial Number 13/433,118 (being now U.S. Patent Publication 2013/0256365) of MATERIALS "；

Entitled " MOVABLE MEMBER FOR USE WITH A TISSUE THICKNESS COMPENSATOR's " U.S. Patent Application Serial Number 13/433,135 (being now U.S. Patent Publication 2013/0256382)；

Entitled " TISSUE THICKNESS COMPENSATOR AND METHOD FOR MAKING THE SAME's " U.S. Patent Application Serial Number 13/433,140 (being now U.S. Patent Publication 2013/0256368)；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING A PLURALITY OF The U.S. Patent Application Serial Number 13/433,129 (being now U.S. Patent Publication 2013/0256367) of MEDICAMENTS "；

Entitled " STAPLE CARTRIDGES FOR FORMING STAPLES HAVING DIFFERING FORMED The U.S. Patent Application Serial Number 11/216,562 (being now United States Patent (USP) 7,669,746) of STAPLE HEIGHTS "；

Entitled " SURGICAL STAPLING DEVICE WITH ANVIL HAVING STAPLE FORMING The U.S. Patent Application Serial Number 11/714,049 of POCKETS OF VARYING DEPTHS " (is now U.S. Patent Publication 2007/0194082)；

Entitled " SURGICAL STAPLING DEVICES THAT PRODUCE FORMED STAPLES HAVING The U.S. Patent Application Serial Number 11/711,979 (being now United States Patent (USP) 8,317,070) of DIFFERENT LENGTHS "；

Entitled " SURGICAL STAPLING DEVICE WITH STAPLE DRIVERS OF DIFFERENT The U.S. Patent Application Serial Number 11/711,975 (being now U.S. Patent Publication 2007/0194079) of HEIGHT "；

Entitled " SURGICAL STAPLING DEVICE WITH STAPLE DRIVER THAT SUPPORTS MULTIPLE WIRE DIAMETER STAPLES " U.S. Patent Application Serial Number 11/711,977 (be now United States Patent (USP) 7, 673,781)；

Entitled " SURGICAL STAPLING DEVICE WITH MULTIPLE STACKED ACTUATOR WEDGE CAMS FOR DRIVING STAPLE DRIVERS " U.S. Patent Application Serial Number 11/712,315 (be now United States Patent (USP) 7, 500,979)；

Entitled " STAPLE CARTRIDGES FOR FORMING STAPLES HAVING DIFFERING FORMED The U.S. Patent Application Serial Number 12/038,939 (being now United States Patent (USP) 7,934,630) of STAPLE HEIGHTS "；

Entitled " SURGICAL STAPLING SYSTEMS THAT PRODUCE FORMED STAPLES HAVING The U.S. Patent Application Serial Number 13/020,263 of DIFFERENT LENGTHS " (is now U.S. Patent Publication 2011/ 0147434)；

Entitled " ROBOTICALLY-CONTROLLED SURGICAL STAPLING DEVICES THAT PRODUCE The U.S. Patent Application Serial Number 13/118,278 of FORMED STAPLES HAVING DIFFERENT LENGTHS " (is now beauty State's patent disclosure 2011/0290851)；

The beauty of entitled " ROBOTICALLY-CONTROLLED CABLE-BASED SURGICAL END EFFECTORS " State's patent application serial number 13/369,629 (being now U.S. Patent Publication 2012/0138660)；

Entitled " SURGICAL STAPLING DEVICES FOR FORMING STAPLES WITH DIFFERENT The U.S. Patent Application Serial Number 12/695,359 (being now United States Patent (USP) 8,464,923) of FORMED HEIGHTS "；

Entitled " STAPLE CARTRIDGES FOR FORMING STAPLES HAVING DIFFERING FORMED The U.S. Patent Application Serial Number 13/072,923 (being now United States Patent (USP) 8,567,656) of STAPLE HEIGHTS "；

The U.S. Patent application sequence of entitled " LAYER OF MATERIAL FOR A SURGICAL END EFFECTOR " Row number 13/766,325 (being now U.S. Patent Publication 2013/0256380)；

The beauty of entitled " ANVIL LAYER ATTACHED TO A PROXIMAL END OF AN END EFFECTOR " State's patent application serial number 13/763,078 (being now U.S. Patent Publication 2013/0256383)；

The U.S. Patent application of entitled " LAYER COMPRISING DEPLOYABLE ATTACHMENT MEMBERS " Sequence number 13/763,094 (being now U.S. Patent Publication 2013/0256377)；

The U.S. of entitled " END EFFECTOR COMPRISING A DISTAL TISSUE ABUTMENT MEMBER " Patent application serial number 13/763,106 (being now U.S. Patent Publication 2013/0256378)；

The United States Patent (USP) Shen of entitled " TISSUE THICKNESS COMPENSATOR COMPRISING CHANNELS " It please sequence number 13/433,147 (being now U.S. Patent Publication 2013/0256369)；

The beauty of entitled " SURGICAL STAPLING CARTRIDGE WITH LAYER RETENTION FEATURES " State's patent application serial number 13/763,112 (being now U.S. Patent Publication 2013/0256379)；

Entitled " ACTUATOR FOR RELEASING A TISSUE THICKNESS COMPENSATOR FROM A The U.S. Patent Application Serial Number 13/763,035 of FASTENER CARTRIDGE " (is now U.S. Patent Publication 2013/ 0214030)；

Entitled " RELEASABLE TISSUE THICKNESS COMPENSATOR AND FASTENER CARTRIDGE The U.S. Patent Application Serial Number 13/763,042 (being now U.S. Patent Publication 2013/0221063) of HAVING THE SAME "；

Entitled " FASTENER CARTRIDGE COMPRISING A RELEASABLE TISSUE THICKNESS The U.S. Patent Application Serial Number 13/763,048 (being now U.S. Patent Publication 2013/0221064) of COMPENSATOR "；

Entitled " FASTENER CARTRIDGE COMPRISING A CUTTING MEMBER FOR RELEASING A The U.S. Patent Application Serial Number 13/763,054 of TISSUE THICKNESS COMPENSATOR "；

Entitled " FASTENER CARTRIDGE COMPRISING A RELEASABLY ATTACHED TISSUE The U.S. Patent Application Serial Number 13/763,065 of THICKNESS COMPENSATOR " (is now U.S. Patent Publication 2013/ 0221065)；

The U.S. Patent application of entitled " STAPLE CARTRIDGE COMPRISING A RELEASABLE COVER " Sequence number 13/763,021；

The United States Patent (USP) Shen of entitled " LAYER ARRANGEMENTS FOR SURGICAL STAPLE CARTRIDGES " It please sequence number 13/763,095 (being now U.S. Patent Publication 2013/0161374)；

The U.S. of entitled " IMPLANTABLE ARRANGEMENTS FOR SURGICAL STAPLE CARTRIDGES " Patent application serial number 13/463,147 (being now U.S. Patent Publication 2013/0292398)；

Entitled " MULTIPLE THICKNESS IMPLANTABLE LAYERS FOR SURGICAL STAPLING The U.S. Patent Application Serial Number 13/763,192 (being now U.S. Patent Publication 2013/0146642) of DEVICES "；

Entitled " RELEASABLE LAYER OF MATERIAL AND SURGICAL END EFFECTOR HAVING The U.S. Patent Application Serial Number 13/763,161 (being now U.S. Patent Publication 2013/0153641) of THE SAME "；

Entitled " ACTUATOR FOR RELEASING A LAYER OF MATERIAL FROM A SURGICAL END The U.S. Patent Application Serial Number 13/763,177 (being now U.S. Patent Publication 2013/0146641) of EFFECTOR "；

The United States Patent (USP) of entitled " STAPLE CARTRIDGE COMPRISING A COMPRESSIBLE PORTION " Patent application serial numbers 13/763,037；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING TISSUE INGROWTH The U.S. Patent Application Serial Number 13/433,126 (being now U.S. Patent Publication 2013/0256366) of FEATURES "；

Entitled " DEVICES AND METHODS FOR ATTACHING TISSUE THICKNESS The U.S. Patent Application Serial Number of COMPENSATING MATERIALS TO SURGICAL STAPLING INSTRUMENTS " 13/433,132 (being now U.S. Patent Publication 2013/0256373).

Entitled " FASTENER CARTRIDGE COMPRISING A TISSUE THICKNESS COMPENSATOR The U.S. Patent Application Serial Number 13/851,703 of INCLUDING OPENINGS THEREIN "；

Entitled " TISSUE THICKNESS COMPENSATOR COMPRISING A CUTTING MEMBER PATH " U.S. Patent Application Serial Number 13/851,676；

The U.S. Patent Application Serial Number 13/851,693 of entitled " FASTENER CARTRIDGE ASSEMBLIES "； And

Entitled " FASTENER CARTRIDGE COMPRISING A TISSUE THICKNESS COMPENSATOR The U.S. Patent Application Serial Number 13/851,684 of AND A GAP SETTING ELEMENT ".

Present applicant also possesses following patent application, and the patent application is submitted by one day with the application and entirely Text is respectively herein incorporated by reference:

The U.S. Patent Application Serial of entitled " STAPLE CARTRIDGE INCLUDING A BARBED STAPLE " Number _ _ _ _ _ _ _ _ _ _ (attorney number END7439USNP)；

The U.S. Patent Application Serial of entitled " STAPLE CARTRIDGE INCLUDING A BARBED STAPLE " Number _ _ _ _ _ _ _ _ _ _ (attorney number END7440USNP)；

The U.S. Patent Application Serial of entitled " STAPLE CARTRIDGE INCLUDING A BARBED STAPLE " Number _ _ _ _ _ _ _ _ _ _ (attorney number END7441USNP)；

The U.S. Patent application of entitled " IMPLANTABLE LAYERS COMPRISING A PRESSED REGION " Sequence number _ _ _ _ _ _ _ _ _ _ (attorney number END7349USNP/130323)；

Entitled " IMPLANTABLE LAYERS AND METHODS FOR ALTERING ONE OR MORE The U.S. of PROPERTIES OF IMPLANTABLE LAYERS FOR USE WITH FASTENING INSTRUMENTS " is special Sharp patent application serial numbers _ _ _ _ _ _ _ _ _ _ (attorney number END7348USNP/130324)；

The U.S. Patent Application Serial Number of entitled " IMPLANTABLE LAYER ASSEMBLIES " _ _ _ _ _ _ _ _ _ _ (generation Manage people file number END7346USNP/130326)；

The U.S. Patent application of entitled " IMPLANTABLE LAYERS COMPRISING A PRESSED REGION " Sequence number _ _ _ _ _ _ _ _ _ _ (attorney number END7345USNP/130327)；And

The United States Patent (USP) of entitled " FASTENING SYSTEM COMPRISING A FIRING MEMBER LOCKOUT " Patent application serial numbers _ _ _ _ _ _ _ _ _ _ (attorney number END7350USNP/130328).

Certain exemplary implementation schemes will now be described, to understand the knot of apparatus and method as disclosed herein on the whole Structure, function, the principle of manufacture and use.One or more examples of these embodiments are shown in the accompanying drawings.This field it is general Logical technical staff will be understood that specifically describing herein and being illustrated in the device and method in attached drawing is unrestricted example Property embodiment, and the range of multiple embodiments of the invention is limited only by the appended claims.In conjunction with an exemplary reality The feature that the scheme of applying shows or describes can be combined with the feature of other embodiments.Such modifications and variations are intended to be included in In the scope of the present invention.

Term " includes " (and including any form, such as " including (comprises) " and " including (comprising) "), " have " (and any form having, such as " with (has) " and " having (having) "), " packet Containing " (and comprising any form, such as " include (includes) " and " including (including) " and " containing " (and contain Any form having, such as " contain (contains) " and " containing (containing) ") for open link-verb.Therefore, " packet Include ", " having ", "comprising" or " containing " one or more elements surgery system, device or equipment there is these or more A element, but it is not limited to that only there are these one or more elements.Equally, " comprising ", " having ", "comprising" or " containing " one Or the element of the systems of multiple features, device or equipment has these one or more features, but be not limited to only to have these one A or multiple features.

Term " nearside " and " distal side " are herein defined as coming relative to the clinician of the handle portions of manipulation surgical instruments It uses.Term " nearside " refers near the part of clinician, and term " distal side " refers to the portion far from clinician Point.It is also understood that using such as "vertical", "horizontal", "up" and "down" in combination with attached drawing herein for the sake of succinct and is clear Etc spatial terminology.However, surgical instruments in many orientations and positions in use, and these terms and it is non-limiting and/ Or absolutization.

Various exemplary means and method are provided to execute laparoscopic type and minimally invasive surgical procedures.However, this field Those of ordinary skill it will be readily understood that various method and apparatus disclosed herein can be used for many surgical operations and application In, including for example combined with open surgery.With continued reference to present embodiment, those of ordinary skill in the art Member will be further understood that, various instruments disclosed herein can in any way in insertion body, such as by natural cavity, pass through Notch or puncturing hole for being formed in tissue etc..The working portion or end effector portion of instrument can be plugged directly into patient's body Interior or can be inserted by the device that enters with service aisle, the end effector and elongated shaft of surgical instruments can pass through the work Make channel and promotes.

Attached drawing is gone to, wherein similar number indicates similar component in all the appended drawings, Fig. 1, which is shown, to be suitable for mending with tissue thickness The exemplary surgical suture and cutting off apparatus 8010 that part component is used together are repaid, described in greater detail below.Surgical stapling It may include anvil block 8014 with cutting off apparatus 8010, which can be around it to the pivotal attachment of elongate staple channel 8016 and by repeatedly Opening and closing.Nail administration assembly 8012 may include anvil block 8014 and channel 8016, and wherein component 8012 can be proximally attached to Form the elongated shaft 8018 of tool portion 8022.When nail administration assembly 8012 is closed or when being at least substantially closed, enforcement division Divide 8022 sufficiently small cross section can be presented, which is suitable for for nail administration assembly 8012 being inserted into across trochar.Various In the case of, component 8012 can be manipulated by the shank 8020 for being connected to axis 8018.Shank 8020 may include user control such as knob 8030, which rotate elongated shaft 8018 and nail administration assembly 8012 around the longitudinal axis of axis 8018.Closure trigger 8026 can pivot in front of pistol grip 8036 to be closed nail administration assembly 8012.For example, when closure trigger 8026 is pressed from both sides When tight, closure release button 8038 can be present in outward on shank 8020, so that release button 8038 can be depressed to unclamp and close It closes trigger 8026 and opens nail administration assembly 8012.The firing trigger 8034 that can be pivoted in front of closure trigger 8026 can Make nail administration assembly 8012 while cutting and suture are clamped at tissue therein.In all cases, percussion triggering can be used Device 8034 uses multiple firing schedules to reduce the size for the power that every stroke needs to be applied by surgical hand.In certain realities It applies in scheme, shank 8020 may include one or more rotatable indicator wheels, can such as indicate the rotatable finger of percussion process Show device wheel 8041.If desired, percussion trip lever 8042 allows trigger system before complete percussion traveling is completed manually Retraction, and in addition, percussion trip lever 8042 allows surgeon in the case where trigger system is blocked and/or is failed Or other clinicians make trigger system bounce back.About surgical stapling and cutting off apparatus 8010 and suitable for being used together with the disclosure Other surgical staplings and cutting off apparatus the entitled " FASTENER that is for example submitted on March 27th, 2013 of additional detail Be described in the U.S. Patent application 13/851,693 of CARTRIDGE ASSEMBLY ", the complete disclosure of the patent with Way of reference is incorporated herein.In addition, the surgical stapling and cutting off apparatus that are powered can also be used together with the disclosure.See, for example, The U.S. Patent Application Publication of entitled " the POWERED SURGICAL STAPLING DEVICE " that submits on August 8th, 2008 The complete disclosure of 2009/0090763A1, the patent are herein incorporated by reference.

In conjunction with Fig. 2 and Fig. 3, firing component (such as percussion component 9090) can be with surgical stapling and cutting off apparatus 8010 together Using to promote the wedge-shaped slides 9126 including multiple wedge pieces 9204, the wedge piece is configured to follow closely and apply from nail It is deployed in the tissue captured between anvil block 8014 and elongate staple channel 8016 with component 8012.In addition, in percussion component E-beam 9102 at 9090 distal part can be conducive to individually be closed and percussion, and during percussion by anvil block 8014 with Elongate staple channel 8016 is spaced apart.E-beam 9102 may include a pair of of top pin 9110, can follow the part of wedge-shaped slides 9126 9218 a pair of of intermediate pin 9112 and base pins or stabilizer blade 9114 and sharp cutting edge 9116, the cutting edge can be constructed At captured tissue can be cut off when firing component 9090 and promoting towards distal side.It hangs down in addition, holding each of cutting edge 9116 The integrated molding top guide part 9118 and intermating guides 9120 proximally outstanding of straight end can further limit tissue assembly Region 9122, to facilitate before cutting off tissue to guide to sharp cutting edge 9116.Intermating guides 9120 are also It can be used for engaging by the staged central member 9124 of adjacent wedge-shaped slides 9126 (Fig. 2) and fire nail administration assembly 8012, the wedge-shaped slides influence nail forming by nail administration assembly 8012.

In all cases, nail bin may include for mending to the thickness for capturing the tissue in the nail from cartridge deployment The device repaid.Referring to fig. 4, nail bin (such as nail bin 10000) can be for example used together simultaneously with surgical stapling with cutting off apparatus 8010 It and may include rigid first part (such as support section 10010) and compressible second part (such as tissue thickness's benefit Repay part 10020).Support section 10010 may include warehouse and multiple nail cavities 10012.Nail 10030 for example can be positioned removedly In each nail cavity 10012.Referring primarily to Fig. 4 and Fig. 5, each nail 10030 may include base portion 10031 and from base portion 10031 One or more legs 10032 of extension.It can be supported by being located in the base portion 10031 that nail 10030 before disposing, is followed closely 10030 Staple drivers support in part 10010, and at the same time the leg 10032 of nail 10030 can be at least partially accommodated into nail cavity 10012 It is interior.In all cases, nail 10030 can be deployed between non-firing position and firing position, so that leg 10032 moves across Tissue thickness compensation part 10020, the top surface for penetrating tissue thickness compensation part 10020 penetrate tissue T, and contact and follow closely The anvil block of 10000 relative positioning of storehouse.When leg 10032 is against deflection, the leg 10032 of each nail 10030 can capture tissue A part of a part of thickness compensation part 10020 and the tissue T in each nail 10030, and apply compressive force to group It knits.Further described above, the leg 10032 of each nail 10030 can be made to deform downwardly toward the base portion 10031 of nail, with shape At nail retention region, in the nail retention region, tissue T and tissue thickness compensation part 10020 can be captured.In various situations Under, nail retention region can be limited between the inner surface of strained leg 10032 and the inner surface of base portion 10031.Nail retention The size in region may depend on a number of factors, the length of such as leg, the diameter of leg, the width of base portion and/or the journey of leg deformation Degree.

In use, as further described above and referring primarily to Fig. 4, surgical stapling and cutting off apparatus 8010 Anvil block such as anvil block 8014 can by press closure trigger 8026 move in the closed position opposite with nail bin 10000 with Promote e-beam 9102.Anvil block 8014 can position tissue against tissue thickness compensation part 10020, and in all cases, example Such as tissue thickness compensation part 10020 is compressed against support section 10010.Once anvil block 8014 suitably positions, then can dispose Nail 10030, it is also shown in FIG. 4.In all cases, as described above, being similar to sliding part 9126 in many aspects (referring to figure 3) nail percussion sliding part 10050 can be moved from the proximal end of nail bin 10000 towards distal end 10002, as shown in Figure 5.When When percussion component 9090 is pushed into, sliding part 10050 can contact staple drivers 10040 and be lifted up nail in nail cavity 10012 Driver 10040.In at least one example, sliding part 10050 and staple drivers 10040 can respectively include one or more oblique Slope or inclined surface, one or more of slopes or inclined surface can cooperate so that not the hitting from them of staple drivers 10040 Hair position moves upwards.When staple drivers 10040 are moving upward in their own nail cavity 10012, staple drivers 10040 It can be lifted up nail 10030, so that nail 10030 can occur from its nail cavity 10012.In all cases, as percussion sequence A part, sliding part 10050 can be such that several nails move upwards simultaneously.

As described above and 10030 nail leg 10032 is followed closely when nail 10030 is in their non-firing position referring to Fig. 5 May extend into is more than support section 10010 in compensating part 10020.In all cases, when nail 10030 is in not firing for they When position, the tip of nail leg 10032 or any other part of nail leg 10032 may not project through tissue thickness compensation part 10020 top tissue contacting surface 10021.In some cases, the tip of nail leg 10032 may include that can cut and penetrate The sharp tip of tissue thickness compensation part 10020.

In all cases, it may be preferred to prevent and/or limit the frictional force between tissue thickness compensation part and nail. Referring now to Fig. 6 to Fig. 8, the tissue thickness compensation part 20220 for being used together with nail bin groupware 20200 may include at least portion Extend through multiple mesopores 20224 of tissue thickness compensation part 20220 with dividing.In all cases, nail bin groupware 20200 can Including staple cartridge body 20210 and the tissue thickness compensation part 20220 releasedly fixed relative to staple cartridge body 20210.Warehouse 20210 It may include such as storehouse platform 20211 and the nail cavity being defined through in storehouse platform 20211 and the main body of entrance staple cartridge body 20210 20212.Nail 20230 can be for example removably positioned in nail cavity 20212.Tissue thickness compensation part 20220 may include tissue Contact surface 20221 (Fig. 7) and platform contact surface 20222 (Fig. 6).Contact with platform surface 20222 can releasedly against Such as the platform 20211 of warehouse 20210 positions, and tissue contacting surface 20221 can be fixed against tissue T for example to be stapled Position.Mesopore 20224 can extend across contact with platform surface 20222 and enter tissue thickness compensation part 20220 in and can Such as the path including hole, slit, gap, bore hole, opening and/or removing in tissue thickness compensation part 20220.

Referring primarily to Fig. 7 and Fig. 8, nail 20230 be can be positioned in the nail cavity 20212 of warehouse 20210.Each nail 20230 can Including base portion 20231 and a pair of of nail leg 20232, for example, the nail leg can extend from base portion 20231.Each nail leg 20232 can be from The opposite both ends of base portion 20231 extend.Referring primarily to Fig. 7, in the mesopore 20224 in tissue thickness compensation part 20220 One or more may include opening in contact with platform surface 20222.The opening of mesopore 20224 can be located in nail cavity Correspondence nail leg 20232 in 20212 is aligned.For example, when tissue thickness compensation part 20220 is fixed relative to warehouse 20210, it is single A nail leg 20232 can be aligned with the opening of single mesopore 20224.In some cases, nail leg 20232 may extend into each In lyriform pore 20224, so that at least part insertion such as tissue thickness compensation part 20220 of nail 20230.For example, main ginseng See Fig. 7, nail 20230 may include the first nail leg 20232a and the second nail leg 20232b.In addition, tissue thickness compensation part 20220 can Including the first mesopore 20224a being for example aligned with the first nail leg 20232a, and be aligned with the second nail leg 20232b second Mesopore 20224b.Before deployment nail 20230, for example, the first nail leg 20232a can extend partially across the first mesopore 20224a, and the second nail leg 20232b can extend partially across the second mesopore 20224b.Tissue thickness compensation part 20220 can Including the modification space hole 20224 not being aligned with nail leg 20232 for example.In some cases, nail bin groupware 20200 may include example Such as the additional nail 20230 and/or nail leg 20232 not being aligned with mesopore 20224.

Nail 20230 never percussion configuration (Fig. 7) can move to percussion configuration (Fig. 8).Each nail 20230 can not fire structure Along nail axial-movement when being moved between type and percussion configuration.When being in non-percussion configuration, nail leg 20232 can be from nail cavity 20212 Extend and enters in such as tissue thickness compensation part 20220.For example, when nail 20230 is in non-percussion configuration, nail leg 20232 It can be partially submerged into tissue thickness compensation part 20220.In addition, for example, nail leg 20232 is extremely when nail is in non-percussion configuration Few a part can be directed at and/or be located in tissue thickness compensation part with the mesopore 20224 of tissue thickness compensation part 20220 Mesopore in.In other cases, when being in non-percussion configuration, nail leg 20232 can be entirely located in nail cavity 20212 It is interior, and can be aligned with the mesopore 20224 being for example located in above storehouse platform 20211 (Fig. 6).

During firing schedule, nail 20230 never percussion configuration (Fig. 7) can move to percussion configuration (Fig. 8), such as this paper institute It states.Staple drivers 20240 can be positioned in each nail cavity 20212.Staple drivers 20240 in each nail cavity 20212 can court Storehouse platform 20211 (Fig. 6) pushes, for example, being somebody's turn to do with that will follow closely 20230 drivings into tissue T and towards the driving of anvil block 20260 (Fig. 8) Anvil block can be similar to other anvil blocks as described herein, such as anvil block 8014 (Fig. 1) in many aspects.20230 are followed closely never each When percussion configuration moves to percussion configuration, the movable mesopore in tissue thickness compensation part 20220 of nail leg 20232 20224.Mesopore 20224 can have the predetermined trajectories in tissue thickness compensation part 20220.For example, mesopore 20224 can be along vertical Directly in and/or be substantially perpendicular to the tissue contacting surface 20221 (Fig. 7) and/or platform of tissue thickness compensation part 20220 The axis of contact surface 20222 (Fig. 6) extends.In other cases, mesopore 20224 can be mended along relative to such as tissue thickness Tissue contacting surface 20221 and/or the contact with platform surface 20222 of part 20220 is repaid to extend with the axis that oblique angle is orientated.Certain In the case of, one group of mesopore 20224 can be parallel.In some cases, for example, institute in tissue thickness compensation part 20220 It can be parallel for having mesopore 20224.Mesopore 20224 may include the path of the curved path in part and/or partial linear.Between Entitled " the FASTENER that other characteristics and feature of lyriform pore 20224 were submitted on March 27th, 2013 It is more fully described in the U.S. Patent application 13/851,693 of CARTRIDGEASSEMBLY ", the complete disclosure of the patent It is herein incorporated by reference.For tissue thickness compensation part is revised as include mesopore such as mesopore 20224 method It is described in more detail below with technology.

Referring now to Fig. 9 to Figure 12, in many aspects similar to the end effector of the surgical instruments of surgical instruments 8010 22090 for example may include first jaw with fastener cartridge assembly 22000 and the second jaw with anvil block 10060.First Jaw may include staple cartridge channel 10070, which is configured to removedly receive storehouse component 22000.Optionally Ground, staple cartridge channel 10070 and storehouse component 22000 may include integral unit.In all cases, anvil block 10060 can be in open position Set and closed position (Fig. 9 is moved between Figure 12).In the open position of anvil block 10060, for example, anvil block 10060 can position In the tissue T of patient, (on the first side of Figure 10 to Figure 12), and storehouse component 22000 can be positioned on the second or opposite of tissue T On side.When anvil block 10060 moves in its closed position, anvil block 10060 can compress tissue T against storehouse component 22000.Optionally Ground, the first jaw including storehouse component 22000 can be moved relative to anvil block 10060.It is similar to percussion component in many aspects The firing member 10052 of 9090 (Fig. 3) can be from the proximal end 22001 of storehouse component 22000 towards the distal end of storehouse component 22000 22002 are promoted towards distal side and are pushed away with the distal end 22002 in firing member 10052 proximally end 22001 towards storehouse component 22000 Into when project fastener, the nail 22030 being such as removedly stored in the warehouse 22010 of storehouse component 22000.

Further described above, nail 22030 can be supported by staple drivers 10040, the staple drivers are movably fixed Position is in the nail cavity 22012 being limited in warehouse 22010.In addition, firing member 10052 is configured in firing member 10052 promote nail percussion sliding part towards distal side in warehouse 22010 when proximally end 22001 is moved towards distal end 22002 10050.In such cases, nail percussion sliding part 10050 is configured to promote staple drivers towards anvil block 10060 10040 and the nail 22030 that is supported on.Substantially, further described above, staple drivers 10040 can make to follow closely 22030 never firing positions (Figure 10) move to firing position (Figure 11 and Figure 12), wherein 22030 accessible anvil blocks 10060 of nail And it is deformed between undeformed configuration (Figure 10) and deformed configuration (Figure 11 and Figure 12).Anvil block 10060 may include forming pit 10062, which is configured to receive nail 22030 and deforms nail.Nail 22030 can be with such as nail 10030 And/or any other nail disclosed herein is same or similar, and therefore, nail 22030 is not more fully described herein. However, readers will note that, nail 22030 includes any suitable shape for example in its undeformed configuration and/or its deformed configuration Shape and/or suitably sized, such as width and/or height.For example, in some cases, not firing position when nail 22030 is in it When setting, nail 22030 may include the height not extended on the platform surface 22011 of warehouse 22010, and in other cases, When nail 22030 is in its non-firing position, nail 22030 may include that the leg of wherein nail 22030 prolongs upwards from platform surface 22011 The height stretched, so that the leg of nail 22030 is at least partially embedded in the tissue thickness compensation part 22010 of storehouse component 22000.

With continued reference to embodiment shown in Fig. 9 to Figure 12, further described above, storehouse component 22000 can Including warehouse 22010 and tissue thickness compensation part 22020.In all cases, warehouse 22010 can be for example similar in many aspects In support section 10010, therefore, for simplicity, many in such aspect do not repeat herein.In addition, tissue is thick Tissue thickness compensation part 10020 can be for example similar in many aspects by spending compensating part 22020.Further described above, Firing member 10052 may include cut portion 10053, which is configured in firing member 10052 towards remote Side crosscutting tissue being located between anvil block 10060 and tissue thickness compensation part 22020 when promoting.Therefore, in all cases, Firing member 10052 is configured to while percussion nail 22030 is to suture tissue T and cut tissue T.In certain situations Under, percussion process can at least partly cause cutting process.In other words, cutting process can lag percussion process.In such feelings Under condition, a part of tissue T can be sewn, and then be cut.

As shown in Fig. 9 to Figure 12, warehouse 22010 may include storehouse cutter slit 22015, which is configured to A part of firing member 10052 is received when firing member 10052 is promoted towards distal side.Further described above, anvil Seat 10060 may include anvil block cutter slit 10065, which is configured in firing member 10052 towards distal side A part of firing member 10052 is received when propulsion.In all cases, tissue thickness compensation part 22020 may include tissue thickness Compensating part cutter slit 22025 is spent, which can be with anvil block cutter slit 10065 and storehouse cutter slit 22015 Alignment, so that firing member 10052 can pass through storehouse cutter slit 22015, anvil block cutter slit 10065 and tissue thickness compensation part simultaneously Cutter slit 22025.In all cases, anvil block cutter slit 10065 can prolong above tissue thickness compensation part cutter slit 22025 It stretches, so that the cut portion 10053 of firing member 10052 can pass through storehouse cutter slit 22015,10065 and of anvil block cutter slit simultaneously Tissue thickness compensation part cutter slit 22025.Tissue thickness compensation part cutter slit 22025 can limit the tissue of cut portion 10053 Thickness compensation part cutter track diameter, wherein tissue thickness compensation part cutter track diameter can be parallel to anvil block cutter track diameter and storehouse cutter track diameter.Various In the case of, tissue thickness compensation part cutter track diameter can be longitudinal, and in some cases, tissue thickness compensation part cutter track diameter can be It is curved.Further described above, curved end effector and curved fastener cartridge are in U.S. Patent application public affairs Have in cloth 2008/0169329 disclosed.Entitled " the CURVED END EFFECTOR FOR A submitted on January 11st, 2007 The U.S. Patent Application Serial Number 11/652,164 of SURGICAL STAPLING DEVICE " (is now U.S. Patent Application Publication 2008/0169329) during complete disclosure is hereby incorporated by reference.In such cases, tissue thickness compensates Part can be curved.In at least one such embodiment, tissue thickness compensation part can be to be curved, to match fastener cartridge Warehouse curvature.For tissue thickness compensation part is revised as include cutter slit such as cutter slit 22025 methods and techniques Hereinafter it is described.

Further described above, tissue thickness compensation part cutter slit 22025 can be in the first seam referring primarily to Fig. 9 It closes and extends between part 22021a and the second sutured portion 22021b, which can be sutured by first group of nail 22030, Second sutured portion can be sutured by second group of nail 22030.Cutter slit 22025 can be by the first sutured portion 22021a releasedly It is connected to the second sutured portion 22021b.In use, as shown in figure 9, cut portion 10053 can be advanced through knife towards distal side narrow Slot 22025 is separated with crosscutting cutter slit 22025 and by the first sutured portion 22021a with the second sutured portion 22021b.At certain In a little situations, cutter slit 22025 may include multiple connectors or bridgeware 22026, can by cut portion 10053 it is crosscutting it Preceding connection the first sutured portion 22021a and the second sutured portion 22021b.In all cases, it is at least compensated in tissue thickness When part 22020 is in uncompressed state, connector 22026 can have and the first sutured portion 22021a and/or the second suturing part Divide the identical thickness of 22021b.It is at least one under such circumstances, connector 22026, the first sutured portion 22021a and/or Second sutured portion 22021b by for example flat or at least substantially flat material piece entirety and can be integrally formed.Each In the case of planting other, the first sutured portion 22021a may include first thickness, and the second sutured portion 22021b may include the second thickness It spends, and connector 22026 may include third thickness, wherein one of first thickness, second thickness and third thickness or more Person may differ from other thickness.

Cutter slit 22025, which may also include, is for example defined in hole therein, such as hole 22024.For example, hole 22024 can be thin It is long and can extend along cutter slit 22025 is longitudinal.In various other situations, the hole in cutter slit 22025 may include any Suitable arrangement.In some cases, hole 22024 may include the perforation being located among connector 22026, using for example Laser cutting operation is formed.In some cases, hole 22024 can be cut to tissue thickness compensation part from material piece 22020, so that hole 22024 and connector 22026 are for example arranged in a manner of being alternately arranged.In other cases, tissue thickness Compensating part 22020 may be molded pore-forming 22024 and have been formed on wherein.In all cases, one or more of hole 22024 can wrap Include such as through-hole.In all cases, one or more of hole 22024 may include such as mesopore.In some cases, hole One or more of 22024 may not include through-hole, and can have the reduction thickness of such as cutter slit 22025 on the contrary.For Tissue thickness compensation part is revised as to include that the methods and techniques in hole such as hole 22024 are hereinafter described.

Further described above, referring again to Fig. 9 to Figure 11, when anvil block 10060 is in an open position, patient Tissue can be positioned in end effector 22090 anvil block 10060 and storehouse component 22000 tissue thickness compensation part 22020 it Between.When anvil block 10060 moves in closed position, the bottom surface or tissue contacting surface 10063 of anvil block 10060 are accessible Tissue T and towards the platform surface of warehouse 22,010 22011 push tissue T.Tissue T can contact tissue thickness compensation part 22020 Top surface or tissue contacting surface 22021, wherein anvil block 10060 can support when anvil block 10060 moves in its closed position By tissue thickness compensation part 22020 press tissue T, and further described above, against warehouse 22010 platform table Compress tissue thickness compensation part 22020 in face 22011.In all cases, tissue thickness compensation part 22020 may include bottom surface 22029, which can abutment platforms surface 22011.In some cases, in tissue thickness compensation part 22020 against storehouse By before compressing, gap may be present between bottom surface 22029 and platform surface 22011 body 22010.In such cases, Tissue thickness compensation part 22020 can be translated towards warehouse before compressing first against warehouse 22010.Work as tissue thickness compensation part 22020 against warehouse 22010 when being compressed, in all cases, the first sutured portion of tissue thickness compensation part 22020 22021a and/or the second sutured portion 22021b can transverse movements.For example, the suture of the first sutured portion 22021a and/or second Part 22021b can move laterally away from storehouse cutter slit 22015.In all cases, connector 22026 is configured to Inhibit such transverse movement between the first sutured portion 22021a and the second sutured portion 22021b.In all cases, main It to be configured to stretch to allow the first sutured portion when anvil block 10060 is closed referring to Figure 11, connector 22026 Some relative lateral motions between 22021a and the second sutured portion 22021b.The case where anvil block 10060 is switched on again Under, connector 22026 is configured to return resiliently to, or at least substantially returns to its non-stretched configuration, and make For as a result, the first sutured portion 22021a and the second sutured portion 22021b is laterally drawn towards its initial position shown in Figure 10 It returns.In addition, when anvil block 10060 moves in its closed position, the compressible tissue T of anvil block 10060.In such cases, group Knitting T can at least partly flow in hole 22024.

When checking Figure 10 to Figure 12, readers will recognize that, the cutter slit 22025 of tissue thickness compensation part 22020 is along it Longitudinal length includes the material fewer than the first sutured portion 22021a and/or the second sutured portion 22021b.In other words, it passes through The longitudinal cross-section of first sutured portion 22021a and/or the second sutured portion 22021b wear the material of crosscutting first amount The longitudinal cross-section of cutter slit 22025 is crossed by the material of the second few amount of the crosscutting material than the first amount.

Once anvil block 10060 has been properly positioned, further described above, firing member 10052 can be towards remote Side is promoted with percussion nail, as shown in figure 11, and cuts tissue T and connector 22026, as shown in figure 12.In addition, tissue thickness Compensating part cutting-in force, tissue cutting-in force, tissue thickness compensation part resistance, and/or tissue resistance can make cutting for firing member 10052 Cut the passivation of part 10053.Blunt knife may not be for example according to preferred mode transecting patient tissue T and/or tissue thickness compensation part 22020.Referring primarily to Figure 12, cut portion 10053 may include such as the first blade area 10053a, the second blade area 10053b And/or third blade area 10053c, wherein the first blade area 10053a is vertically oriented on above the second blade area 10053b, and Wherein the second blade area 10053b is vertically oriented on above such as third blade area 10053c.Cut portion 10053 may include appointing The blade area of what suitable number and/or position, wherein blade area shown in Figure 12 selected for purposes of discussion.To above It is described further, the first blade area 10053a is configured to transecting patient tissue T, and the second blade area 10053b can quilt It is constructed to be permeable to transecting patient tissue thickness compensation part 22020.As a result, the first blade area 10053a can be subjected to above-mentioned tissue incision Power and/or tissue resistance.The first blade area 10053a can be worn with first rate or be passivated to such power.Second blade area 10053b It can be subjected to above-mentioned tissue thickness compensation part cutting-in force and/or tissue thickness compensation part resistance.Such power can be worn with the second rate Or the second blade area 10053b of passivation.In all cases, the second rate may differ from first rate.

Turning now to Figure 13 and Figure 14, fastener cartridge 22400 may include tissue thickness compensation part 22420, the tissue thickness Compensating part may include the first sutured portion 22421a and the second sutured portion 22421b connected by cutter slit 22425.Cutter slit 22425 may include angled longitudinally connected device 22426.Angled longitudinally connected device 22426 can be in the close of cutter slit 22425 Extend between side end 22401 and the distal end 22402 of cutter slit 22425.In some cases, angled longitudinally connected Device 22426 may extend away the whole length of cutter slit 22425, and in other cases, angled longitudinally connected device 22426 can prolong Stretch the length less than cutter slit 22425.Angled longitudinally connected device 22426 can be at the top of tissue thickness compensation part 22420 Extend between surface 22428 and the bottom surface 22429 of tissue thickness compensation part 22420.In some cases, angled vertical It may extend away the entire distance between top surface 22428 and bottom surface 22429 to connector 22426, and in other cases, Angled longitudinally connected device 22426 is extensible to be less than the distance between top surface 22428 and bottom surface 22429.Each In the case of kind, the proximal end of longitudinally connected device 22426 can extend from the top surface 22428 of tissue thickness compensation part, and indulge It can extend to the distal end of connector 22426 from bottom surface 22429.Alternatively, the distal end of longitudinally connected device 22426 It can extend from the top surface 22428 of tissue thickness compensation part, and the proximal end of longitudinally connected device 22426 can be from bottom surface 22429 extend.In all cases, longitudinally connected device 22426 may include thin bridgeware (that is, being less than tissue thickness compensation part 22420 whole thickness) a series of or thin bridgewares, which can for example engage the first sutured portion 22421a to the Two sutured portion 22421b, first sutured portion can be sutured by first group of nail 22030, which can be by second group 22030 suture of nail.These thin, angled bridgewares and/or longitudinally connected device 22426 can be on the second blade area 10053b Distribution abrasion, rather than concentrated on a point.In all cases, as a result, for example, appearing in the second blade area Abrasion on 10053b can be equal to or be nearly equal to the abrasion present in the first blade area 10053a.

Referring now to Figure 15 to Figure 17, example organization thickness compensation part component 1000 may include first layer 1002 and can be attached It is connected to the second layer 1004 of first layer 1002.Tissue thickness compensation part component 1000 can use surgical instruments, such as surgical instruments 8010 (Fig. 1) are used.In addition, tissue thickness compensation part component 1000 can be with the storehouse component 22000 of end effector 22090 The similar mode of tissue thickness compensation part 22020 come using and alternative tissue thickness compensation part 22020 (Fig. 9).For example, The second layer 1004 of tissue thickness compensation part component 1000 may include that mode that can be similar with the first sutured portion 22021a is determined First part 1006 of the position on the platform surface 22011 on the first side of storehouse cutter slit 22015, and can be with the second suture Part 22021b similar mode is located in the platform surface in second side opposite with the first side of storehouse cutter slit 22015 (Fig. 9 to Figure 11) of second part 1008 on 22011.In all cases, the first part 1006 and second of the second layer 1004 Part 1008 can be spaced apart and can therebetween include gap 1010, which may include the cutting for firing member 10052 The cutter track diameter of part 10053 and can be when tissue thickness compensation part component 1000 is assembled with storehouse end effector 22090 at least Partly extend above storehouse cutter slit 22015.In some cases, first layer 1002 is configured to connection first Points 1006 and second part 1008 and at least partly extend above gap 1010, such as shown in figure 17.

In use, tissue T can be trapped between anvil block 10060 and the tissue contacting surface 1012 of first layer 1002. When firing member 10052 is pushed into, first group of nail 20030 can be disposed to suture first part 1006 and second group of nail can It is disposed to suture second part 1008.First group of nail and second group of nail are configured to penetrate the second layer 1004 respectively First contact with platform surface 1007 and the second contact with platform surface 1009, then penetrate the tissue contacting surface 1012 of first layer, Then captured tissue T is penetrated to contact the pit 10062 of anvil block 10060.In addition, the propulsion of firing member 10052 can cause Cut portion 10053 is set to be advanced through the gap 1010 of tissue thickness compensation part component 1000 towards distal side.Cut portion 10053 can Crosscutting first layer 1002, while it being advanced through gap 1010, thus by the first part 1006 of the second layer 1004 and second part 1008 separation.

Referring again to Figure 17, the first layer 1002 of tissue thickness compensation part component 1000 may include the first height H1, second The first part 1006 of layer 1004 may include the second height H2, and the second part 1008 of the second layer 1004 may include third height Spend H3.In some cases, as shown in figure 17, the second height H2 and third height H3 can be identical or substantially the same.? In the case of other, the second height H2 may differ from third height H3.In some cases, the first height H1 is smaller than the second height H2 and/or third height H3, as shown in figure 17.The first layer 1002 of tissue thickness compensation part component 1000 may include first close Degree, the first part 1006 of the second layer 1004 may include the second density, and the second part 1008 of the second layer 1004 may include Third density.In some cases, as shown in figure 17, the second density and third density can be identical or substantially the same.? In the case of other, the second density may differ from third density and/or the first density different from first layer 1002.First Points 1006 and the material composition of second part 1008 can be identical or at least substantially identical.In other cases, first Points 1006 and the material composition of second part 1008 can material group different from each other and/or may differ from first layer 1002 At.

As described above, reusing cut portion 10053 can be passivated and cut to cut tissue T and tissue thickness compensation part material Cut part 10053.In order to slow down passivating process, it may be necessary to reduce the tissue thickness compensation part cut by cut portion 10053 Material.Additional benefit can be that power needed for promoting firing member 10052 towards distal side during firing schedule reduces.In order to reduce The passivation of cut portion 10053, first layer 1002 can at least partly include such as film.In such cases, the first height H1 can be significantly less than the second height H2 and third height H3, as shown in figure 17.In some cases, first layer 1002 can have and wear Evenly or substantially upper uniform height therein is crossed, as shown in figure 17.In other cases, the gap bridges portion of first layer 1002 Divide 1014 can at least partly extend above gap 1010 and the remainder of comparable first layer 1002 is thin.Cut portion 10053 can the gap bridges part 1014 of crosscutting first layer 1002 be advanced through 1006 He of first part of the second layer 1004 simultaneously Gap 1010 between second part 1008, this can reduce the resistance that cut portion 10053 is subjected to and/or slow down cutting The passivation of part 10053.Under any circumstance, first layer 1002 is configured to maintenance and the second layer before being crosscut The connection engagement of 1004 first part 1006 and second part 1008, and be pushed into cut portion 10053 with crosscutting the Cut portion 10053 is presented in the resistance of reduction at one layer 1002.

In order to be further reduced the resistance for being passivated and/or reducing cut portion 10053 and be subjected to of cut portion 10053 Power, gap bridges part 1014 may include the perforated section 1016 along the cutter track diameter limited by gap 1010, as shown in figure 16.Perforation Section 1016 may include multiple perforation 1018, and the perforation can be cut before first layer 1002 is for example assembled into the second layer 1004 In first layer 1002.When cut portion 10053 is advanced through the cutter track diameter limited by gap 1010, perforation 1018 can reduce Interaction between cut portion 10053 and first layer 1002, this can slow down cut portion 10053 passivation and/or Reduce the resistance that cut portion 10053 is subjected to.

In all cases, as described in greater detail below, tissue thickness compensation part component 1000 can be by one or more Biocompatible materials are constituted.In some cases, first layer 1002 can be by such as biocompatibility backing material and/or plasticity Material (such as polydioxanone (PDS) and/or polyglycolic acid (PGA)) is constituted, and the second layer 1004 can be by can for example give birth to The foamed material and/or compressible hemostatic material (such as, oxidized regenerated cellulose (ORC)) that object absorbs are constituted.In certain situations Under, first layer 1002 can be the film including, for example, bioabsorbable material, and the bioabsorbable material is such as with quotient The polyglycolic acid (PGA) of name of an article Vicryl sale, polylactic acid (PLA or PLLA), polydioxanone (PDS), poly- hydroxyalkanoate Acid esters (PHA), with trade name Monocryl sell Poliglecaprone 25 (PGCL), polycaprolactone (PCL), and/or PGA, PLA, The compound of PDS, PHA, PGCL and/or PCL.In some cases, the first part 1006 of the second layer 1004 and/or second Divide 1008 can be made of the freeze dried foam for example comprising polylactic acid (PLA) and/or polyglycolic acid (PGA).In some cases, Two layer 1004 of first part 1006 and/or second part 1008 can be made of biocompatible foam, the bio-compatible sex vesicle Foam may include porous open celled foam and/or porous closed-cell foam.

Referring again to Figure 15 and Figure 17, first layer 1002 be may be at least partially disposed on the second layer 1004, so that working as group When knitting thickness compensation part component 1000 and being assembled with end effector 22090 (Fig. 9), the second layer 1004 can be positioned on first layer 1002 Between platform surface 22011 (Fig. 9).In other cases, first layer 1002 can be positioned on first part 1006 and second Divide under 1008 (not shown), so that when tissue thickness compensation part component 1000 is assembled with end effector 22090 (Fig. 9), the It can be positioned on for one layer 1002 between the second layer 1004 and platform surface 22011 (Fig. 9).Under any circumstance, first layer 1002 can It is attached to the first contact surface 1020 of the first part 1006 of the second layer 1004 and the second contact surface of second part 1008 1022.First layer 1002 can be as follows by being related to being attached to the second layer 1004 and applying the thermal pressing process of heat and/or pressure It is more fully described in text.In other cases, first layer 1002 can be such as fine for example, by biocompatible adhesive material Fibrillarin and/or protein hydrogel are attached to the second layer 1004.The disclosure is contemplated for first layer 1002 to be attached to second The other modes of layer 1004.

Referring now to Figure 21 and Figure 22, first layer 1002 can be at least partially embedded the first part 1006 of the second layer 1004 And/or in second part 1008.In such cases, mold 1024 can be used to prepare for tissue thickness compensation part component 1000, Such as shown in figure 21.In all cases, can will include polymer (such as polylactic acid (PLA) and/or polyglycolic acid (PGA)) Organic solution pour into mold 1024.First layer 1002 can be immersed in organic solution.As shown in figure 22, die cover 1028 Centre frame 1026 and center sill 1027 first layer 1002 can be clipped between the two with ensure first layer 1002 keep immerse it is organic In solution, then which such as conventional lyophilizing technique and/or any other suitable technology can be used to be lyophilized.Complete After freeze-drying process and/or any other suitable process, die cover 1028 can be removed and tissue thickness compensation part group Part 1000 can be recycled from mold 1028.

As shown in figure 21, the first layer 1002 of tissue thickness compensation part 1000 can be partially positioned at the of the second layer 1004 In a part 1006 and second part 1008.In some cases, first layer 1002 can be partially positioned at first part 1006 With in one of second part 1008 and be attached to the top of the other of first part 1006 and second part 1008 Surface or bottom surface.

In some cases, when lid 1028 and mold 1024 are in closed configuration, center sill 1027 and frame 1026 can be extremely Partially along being parallel to or be arranged essentially parallel to the first contact with platform surface 1007 and/or the second contact with platform surface 1009 Axis extends, as shown in figure 22.In such cases, the embeddable first part 1006 of first layer 1002 and/or second part In 1008 so that first layer 1002 with parallel with the first contact with platform surface 1007 and/or the second contact with platform surface 1009 or Substantially parallel relationship positioning substantially positions.In other cases, although it is not shown, but when lid 1028 and mold 1024 When in closed configuration, center sill 1027 and frame 1026 can at least partly along with the first contact with platform surface 1007 and/or the The axis of two contact with platform surfaces, 1008 bevel extends.In such cases, the embeddable first part 1006 of first layer 1002 And/or in second part 1008, so that first layer 1002 is relative to the first contact with platform surface 1007 and/or the second contact with platform Surface 1009 is positioned with oblique angle or is substantially positioned.The disclosure is susceptible to for first layer 1002 to be partially embedded into first part 1006 and/or second part 1008 in other technologies.

Referring now to Figure 18 and Figure 19, shows and be similar to tissue thickness compensation part component 1000 and tissue in many aspects The tissue thickness compensation part component 1033 of thickness compensation part 20020.Tissue thickness compensation part component 1033 may include that can be spaced apart And the first part 1006 be separably linked together by multiple bridge members or connector 1030 and second part 1008, The bridge member or connector can extend across the gap 1010 between first part 1006 and second part 1008.In addition, group Some or all of the connector 1030 for knitting thickness compensation part component 1033 can be partially embedded into first part 1006 and second In part 1008, as shown in figure 19.In addition, some or all of connector 1030 may include being located in first part 1006 First end, the second end that is located in second part 1008, and gap bridges part 1032 between the two.Gap bridge Socket part point 1032 can extend across the gap 1010 between first part 1006 and second part 1008, as shown in figure 19.Connector 1030 can be spaced apart along the length in gap 1010 first part 1006 is detachably coupled to second part 1008.

In some cases, connector 1030 can be evenly distributed along the axis extended along gap 1010, such as Figure 19 institute Show.In other cases, although it is not shown, but connector 1030 can unevenly divide along the axis extended along gap 1010 Cloth.Cut portion 10053 is configured in cut portion 10053 between first part 1006 and second part 1008 It is advanced through the gap bridges part 1032 of crosscutting connector 1030 when the cutter track diameter limited by gap 1010.In connector 1030 In the case where being unevenly distributed along the axis of first part 1006 and second part extension, at least one situation, Connector 1030 at the distal segment in gap 1010 than at the proximal section in gap 1010 with bigger frequency and/or Person is closer to each other to be arranged, so that cut portion 10053 can be subjected to increasing when promoting along the cutter track diameter limited by gap 1010 The resistance added.In other cases, connector 1030 saves at the proximal section in gap 1010 than the distal side in gap 1010 At section with bigger frequency and/or it is closer to each other be arranged, such as make the cut portion 10053 along by gap 1010 The cutter track diameter of restriction can be subjected to reduced resistance when promoting.

In some cases, connector 1030 can be parallel to or be arranged essentially parallel to the first contact with platform part 1007 And/or second contact with platform part 1009 single plane in extend or substantially extend, as shown in figure 19.In other situations Under, although it is not shown, but connector 1030 can be along can be parallel to each other or be substantially parallel to each other and/or be parallel to or substantially On be parallel to multiple planes of the first contact with platform part 1007 and/or the second contact with platform part 1009 and extend or substantially prolong It stretches.

Further described above, some or all of gap bridges part 1032 of connector 1030 is than it The rest part of corresponding connectors 1030 is thin to be pushed into cut portion 10053 to make cut portion when crosscutting connector 1030 10053 are presented under the resistance of reduction, while maintaining the first part 1006 of the second layer 1004 and the connection of second part 1008 Engagement.For example, some or all of connector 1030 may include dog-bone shapes, which, which has, is terminated in the second layer Thicker end portion in 1004 first part 1006 and second part 1008 and the relatively thin central part extended therebetween.Certain In the case of, connector 1030 can one section of suture of each freedom constitute, which can be made of bioabsorbable material, described Bioabsorbable material is such as with the polyglycolic acid (PGA) of trade name Vicryl sale, polylactic acid (PLA or PLLA), poly- two Six cyclic ketones of oxygen (PDS), the Poliglecaprone 25 (PGCL) sold with trade name Monocryl, gathers oneself at polyhydroxyalkanoatefrom (PHA) The compound of lactone (PCL), and/or PGA, PLA, PDS, PHA, PGCL and/or PCL.

Referring again to Figure 18, mold 1034 can be used to prepare for tissue thickness compensation part component 1033.It can will include polymerization The organic solution of object (such as polylactic acid (PLA) and/or polyglycolic acid (PGA)) pours into mold 1034.It can be by connector 1030 immerse in organic solution.As shown in figure 18, one or more of connector 1030 can each freedom prolong from die cover 1038 In the dedicated slit 1040 of one or more that the one or more beams 1039 stretched are clipped on centre frame 1036 and it is adapted to It is enough in and engages when die cover 1038 is in closed configuration with mold 1034 with the cooperation of slit 1040 to ensure connector 1030 It remains immersed in organic solution.The size of slit 1040 can be configured to receive or at least partly receive bridging part 1032, when die cover 1038 is in closed configuration with mold 1034, which can be fixed by beam 1039.Connector 1030 Slave gap bridges part 1032 extend end can freely be floated in organic solution.Alternatively, the end of connector 1030 It can be fixed the side of such as mold 1034.In some cases, connector 1030 can between the side of mold 1034 It is stretched in organic solution.In other cases, connector 1030 can be loosely retained between the side of mold 1034 so as to example As extended through organic solution in a non-linear manner.

Further described above, in all cases, then organic solution can be used conventional lyophilizing technique and/or Any other suitable technology is lyophilized.After completing freeze-drying process, die cover 1036 can be removed and tissue thickness is mended Repaying part component 1033 can recycle from mold 1034.As shown in figure 19, gained tissue thickness compensation part component 1033 includes partly The connector 1030 being located in first part 1006 and second part 1008.The disclosure is susceptible to for by connector 1030 Divide the other technologies in ground insertion first part 1006 and/or second part 1008.It will be appreciate that connector 1030 can pass through Change the height of centre frame 1038 and/or the depth of slit 1040 and closer to or further from contact with platform surface 1007 and 1009 Positioning.

Referring now to Figure 20, shows and be similar to tissue thickness compensation part component 1033 in many aspects, tissue thickness compensates The tissue thickness compensation part component 1042 of part component 1000 and/or tissue thickness compensation part 20020.Tissue thickness compensation part component 1042 may include that can be spaced apart and by can by the continuous flexible component 1044 that multiple bridge members or connector 1046 are formed The first part 1006 being discretely linked together and second part 1008, the bridge member or connector can be across first parts Gap 1010 between 1006 and second part 1008 extends.Continuous flexible component 1044 may include first end 1048, second End 1050, and the flexible portion 1052 extended between first end 1048 and the second end 1050.Flexible portion 1052 It is configured to for example extend through first part 1006 and second part 1008 several times to be formed with zigzag pattern Connector 1046, as shown in figure 20.Flexible portion 1052 can pass through the distal segment 1054 of first part 1006 along first direction Distal segment 1056 with second part 1008 is to form the first gap bridges part 1046a across gap 1010.Flexible portion Then 1052 can recycle along the second direction opposite with first direction and pass through the second part in 1056 nearside of distal segment 1008 and pass through 1054 nearside of distal segment first part 1006, to be formed in the first gap bridges part 1046a Second gap bridges part 1046b of nearside.Modification space bridging part 1046c and 1046d for example can in the same manner across The formation of gap 1010, as shown in figure 20.

In some cases, continuous flexible component 1044 may include suture and can be made of suture material, described Suture material is such as with the polyglycolic acid (PGA) of trade name Vicryl sale, polylactic acid (PLA or PLLA), poly- dioxane Ketone (PDS), polyhydroxyalkanoatefrom (PHA), Poliglecaprone 25 (PGCL), the polycaprolactone sold with trade name Monocryl (PCL), and/or the compound of PGA, PLA, PDS, PHA, PGCL and/or PCL.In some cases, tissue thickness compensation part group Part 1042 can be in the later assembling of first part 1006 and second part 1008 for example by the way that manufacture is lyophilized.In some cases, Needle (not shown) could attach to the first end 1048 of continuous flexible component 1044 and for example can pass through the with zigzag pattern A part 1006 and second part 1008 are to be connected to second part 1008 for first part 1006, as described above.Continuous flexible The first end 1048 and/or the second end 1050 of component 1044 can be by such as first end 1048 and/or the second ends The side wall that one or more is tied and is fixed to first part 1006 and/or second part 1008 is fastened at 1050.Knot can be against the The side wall of a part 1006 and/or second part 1008 is to prevent flexible portion 1052 relative to first part 1006 and/or the It unlocks two parts 1008.In other cases, the first part 1006 of tissue thickness compensation part component 1042 and second part 1008 can be around the formation of continuous flexible component 1044.In such cases, as shown in figure 20, continuous flexible component 1044 can be such as It is arranged in mold 1062 with zigzag pattern, wherein slit 1064 is limited in side wall 1066 and during slit 1068 is limited to In heart frame 1070.Organic solution comprising polymer (such as polylactic acid (PLA) and/or polyglycolic acid (PGA)) can be poured into In mold 1062, until continuous flexible component 1044 is immersed in organic solution.Die cover 1072 can be used for ensuring continuous flexible Component 1044 remains immersed in organic solution, which then uses conventional lyophilizing technique and/or any other is suitable Technology be lyophilized.For example make first end 1048 pass through opening 1053 and make the second end 1050 pass through opening 1055 it Afterwards, the first end 1048 of continuous flexible component 1044 and the second end 1050 can be by first end 1048 and the second ends One or more knots are fastened at 1050 and are separately fixed at the opening 1053 and 1055 of mold 1062.Knot can abut mold 1062 Side wall to prevent continuous flexible component 1044 from unlocking relative to mold 1066.It has been removed from mold in tissue thickness compensation part Afterwards, in all cases, then the part (such as part 1048,1050 and/or 1052) of continuous flexible component 1044 can be cut It cuts and is removed from tissue thickness compensation part.The disclosure is susceptible to other skills for assembling tissue thickness compensation part component 1042 Art.

In some cases, when excessive power or pressure are applied to tissue thickness compensation part component (such as tissue thickness Compensating part component 1042) when, it can damage.For example, when tissue thickness compensation part component 1042 is loaded into nail bin (such as nail bin 10000) it when on, can pressure is applied on tissue thickness compensation part component (such as tissue thickness compensation part component 1042).Group Pressure or power sensitive components can be equipped with by knitting thickness compensation part component 1042, and the pressure or power sensitive components can be provided to user The pressure that tissue thickness compensation part component is subjected to whether be more than threshold value warning feedback.For example, pressure or power sensitive membrane can be attached It is connected to tissue thickness compensation part component 1042 and is configured to change color when being subjected to the pressure more than threshold value.? In some cases, pressure or power sensitive membrane may be disposed at first part 1006 and/or 1008 top of second part and can lead to Such as adhesive is crossed to be attached to thereon.Pressure or power sensitive membrane can be biocompatible to allow with tissue thickness compensation part group Pressure or power sensitive membrane are implanted into the patient by part 1042.

Referring now to Figure 23 to Figure 25, surgical end-effector 1100 is shown.End effector 1100 is in many aspects Similar to disclosed various end effectors elsewhere herein, such as end effector 22090 (Fig. 9).As shown in figure 23, end Actuator 1100 may include the nail bin groupware 1102 for being for example similar to nail bin groupware 20200 (Fig. 6) in many aspects.In addition, end Portion's actuator 1100 may include for example being similar to this document disclosed other tissue thickness compensation parts elsewhere in many aspects (such as tissue thickness compensation part 22020 (Fig. 9), tissue thickness compensation part 20220 (Fig. 6) and/or tissue thickness compensation part 10020 (Fig. 4)) tissue thickness compensation part 1104.

Further described above, end effector 1100 may include tissue thickness compensation part 1104, wherein organizing Conventional lyophilizing technique and/or any other suitable technology can be used to prepare for thickness compensation part 1104.In at least one example In, tissue thickness compensation part 1104 can be by being dissolved in polymer (such as polylactic acid (PLA) and/or polyglycolic acid (PGA)) In organic solvent and make solution freeze-drying to prepare.Tissue thickness compensation part 1104 can be made of biocompatible foam, the life Object biocompatible foam may include for example porous open celled foam and/or porous closed-cell foam.

Further described above, tissue thickness compensation part 1104 can be changed or modified for surgical operation In.For example, tissue thickness compensation part 1104 can be contacted with modification component 1106 to modify tissue thickness after completing freeze-drying process Compensating part 1104 is spent in specific surgical procedure.In some cases, modification can be by 1104 groups of tissue thickness compensation part Equipped with progress after end effector 1100, as shown in Figure 23 to Figure 35.For example, as shown in figure 23, tissue thickness compensation part 1104 can releasedly be assembled into storehouse component 1102 and the modification when being assembled with storehouse component 1102.In other cases, it repairs Changing can carry out before tissue thickness compensation part 1104 is assembled with end effector 1100.In at least one example, it is making During making, modification can be used as independent step and carry out.In yet another example, modification can carry out during surgery.

As described in greater detail below, modification process can be related to modification tissue thickness compensation part 1104 surface or multiple tables Face.In some cases, modification process can be related to one or more parts of modification tissue thickness compensation part 1104.One or more A part can modify during single modification.Alternatively, multiple portions can individually be modified during each comfortable continuous modification. In some cases, modification process may include thermal pressing process, which can be used for changing tissue thickness compensation part 1104 at least part of shape, size, size and/or porosity.In addition, modification process may include in tissue thickness The mode in space is formed in one or more parts of compensating part 1104.

Referring again to Figure 23 to Figure 25, in some cases, the part 1107 (Figure 23) of tissue thickness compensation part 1104 can Modified by thermal pressing process, which may include that part 1107 is transformed into glassy state, by part 1107 with repair Change the engagement of component 1106, pressure is applied to thereon when part 1107 is in glassy state, and part 1107 is made to be cooled to glass Under glass state, while modifying component 1106 and still being engaged with part 1107.Modification component 1106 can be used for maintaining on part 1107 Pressure is persistently enough to form the period of gained modification part 1108 (Figure 25).It is worth noting that, material turns to glassy state Become can for the temperature in response to material increases to glass transition temperature and from relatively hard state to relative melt or flexibility shape The reversible transition of state.The glass transition temperature of material can be specific temperature, or in some cases be certain temperature model It encloses.Tissue thickness compensation part modification process as described herein utilizes the phenomenon in the following manner: in tissue thickness compensation part Tissue thickness compensation part is modified when in glass flexibility state, then so that tissue thickness compensation part is cooled to glass when maintaining modification Below glass transition temperature.

Further described above, referring again to Figure 23 to Figure 25, the part 1107 of tissue thickness compensation part 1004 Glassy state can be transformed into the following manner: part 1107 is at least heated to the glass transition temperature more than or equal to material Degree but is below the temperature of its melting temperature, and part 1107 is made of the material.For example, tissue thickness compensation part 1104 can be by Polyglycolic acid (PGA) is constituted, and in such cases, part 1107 can be transformed into the following manner glassy state: by part 1107 glass transition temperatures for being heated to more than or equal to polyglycolic acid (PGA) but are below the temperature of its melting temperature.? In various situations, the glass transition temperature of polyglycolic acid (PGA) can be in the range of such as 35-40 DEG C, and its melting is warm Degree can be in the range of such as 225-230 DEG C.In at least one example, the part 1107 of tissue thickness compensation part 1104 can quilt It is heated to the temperature for being greater than or equal to 35 DEG C but being lower than 225 DEG C, so that part 1107 is transformed into glassy state.In another example In, part 1107 can be transformed into the following manner glassy state: part 1107 being heated to be greater than or is equal to 40 DEG C but low In 200 DEG C of temperature.

Further described above, then modification component 1106 can be used for press when part 1107 is in glassy state Power is applied on part 1107.Part 1107 can be made to exit glass for example, by part 1107 is cool below 35 DEG C of temperature Glass state.Pressure can be maintained to be enough to allow tissue thickness compensation part 1104 to keep or at least partly keep by modification component 1106 The period of the modification of application.

In certain embodiments, pressure can be maintained for example about 30 seconds to about 8 hours during the time in glassy state Period and/or about 30 seconds to about 8 hours periods are for example maintained after exiting glassy state.In at least one example In, pressure can maintain about 10 minutes during the time in glassy state and maintain about 10 points after exiting glassy state Clock.The disclosure is susceptible to the other times section for maintaining pressure.

In some cases, modification component 1106 can be used for before part 1107 is transformed into glassy state pressure is applied to On part 1107.In some cases, modification component 1106 can be when part 1107 be heated to reach glassy state, in part 1107 when being in glassy state, and/or when part 1107 changes or be cooled to glassy state temperature below to part 1107 Apply pressure.In some cases, when such as the temperature in part 1107 is gradually increased so that part 1107 towards glassy transition, The pressure for being applied to part 1107 can gradually increase towards threshold value.In some cases, when glassy state is exited in part 1107, in portion 1107 are divided to exit before glassy state, and/or after glassy state is exited in part 1107, the pressure for being applied to part 1107 can It is removed, gradually removes, or at least partly reduce.

In some cases, modification component 1106 can also be 1107 turns of the part for making tissue thickness compensation part 1104 Become the heat source of glassy state.For example, modification component 1106 may include cylindrical distal part 1110, as shown in figure 24, the cylinder Shape distal part may include heating coil (not shown).User can make heating coil be powered and by tissue thickness compensation part 1104 part 1107 is engaged with modification component 1106 part 1107 to be heated to the material group more than or equal to part 1107 Close the temperature of the glass transition temperature of object.Once reach required temperature, can bearing part 1107 pressing modification component, such as Figure 24 It is shown.It alternatively, can the pressing modification component of bearing part 1107 before modification component 1106 reaches required temperature.Institute as above It states, pressure can be maintained to be enough to allow tissue thickness compensation part 1104 to keep or at least partly keep being applied by modification component 1106 The period of the modification added.In addition, the heating coil of modification component 1106 can be closed so that the temperature of part 1107 is cooled to Lower than glass transition temperature.Then modification component can be removed.In some cases, the pressure applied by modification component 1106 It can be initiated before part 1107 enters glassy state and be maintained in entire glassy state.In some cases, in portion Points 1107 when being in glassy state, and the pressure applied by modification component 1106 can be removed.

As shown in Figure 23 to Figure 25, modification component 1106 is configured to change the portion of tissue thickness compensation part 1104 Divide 1107 shape, size, size, density, flexible ratio and/or porosity.For example, modification part 1108 may include having to subtract The substantially concave top surface 1114 of low height H1, and the remainder of tissue thickness compensation part 1104 can keep including big In the substantially flat top surface for the elemental height H for reducing height H1, as shown in figure 25.As described above, modification component 1106 may include cylindrical distal part 1110.In such cases, the curvature of gained concave surface 1114 can partly depend on In the cylindrical distal side for the modification component 1106 that the part 1107 during modification process with tissue thickness compensation part 1104 contacts The curvature of part 1110.In addition, modification part 1108 can have with the relatively low new porosity in unmodified part 1107, this can At least partly by being caused during modification process by the compressing force that modification component 1106 is applied to part 1107, as described above. In other words, the pressure that part 1107 is applied to during modification process can produce material redistribution, wherein in modification process There can be the density of material bigger than the similar cross-section by part 1107 by the cross section of modification part 1108 before.This Outside, modification part 1108 can have the flexible ratio different from the remainder of tissue thickness compensation part 1104, this can be partly It is as follows to retouch in more detail by being caused during modification process by modifying the change of density and porosity that part 1108 is realized It states.In at least one situation, modification part 1108 flexible ratio be smaller than or greater than unmodified part 1107 elastic ratio Rate.

Referring now to Figure 26 to Figure 34, tissue thickness compensation part can be assembled with end effector such as end effector It is modified before 22090 (Fig. 9).In some cases, as shown in Figure 27, Figure 30 and Figure 33, mold may be used in hot pressing Process modifies tissue thickness compensation part, as described above.For example, tissue thickness compensation part 1120 can quilt as shown in Figure 26 to Figure 28 It is revised as including longitudinal slit 1122.Tissue thickness compensation part 1120 can be similar to its hetero-organization described in other places in many aspects Thickness compensation part, such as tissue thickness compensation part 22020 (Fig. 9).For example, compensating part 1120 can be with end such as compensating part 22020 Portion's actuator 22090 is used together.In addition, longitudinal slit 1122 can be similar to cutter slit 22025 in many aspects.For example, such as With cutter slit 22025, the tissue thickness compensation part cutter track diameter for being used for cut portion 10053 can be limited to the first seam by slit 1122 It closes between part 1124a and the second sutured portion 1124b.In addition, the first sutured portion 1124a and the second sutured portion 1124b It can be analogous respectively to the suture of the first sutured portion 22021a (Fig. 9) and second of tissue thickness compensation part 22020 in many aspects Part 22021b (Fig. 9).In addition, slit 1122 is configured to be releasably attached the first sutured portion 1124a and Two sutured portion 1124b, so that cut portion 10053 can be promoted towards distal side and be worn when being used together with end effector 22090 Slit 1122 is crossed to separate with crosscutting slit 1122 and by the first sutured portion 1124a and the second sutured portion 1124b.

Referring again to Figure 26 to Figure 28, tissue thickness compensation part 1120 can be used traditional freeze drying technology and/or any other It is prepared by suitable technology.In addition, tissue thickness compensation part 1120 can be modified or varied to form slit 1122 to pass through. Similar to tissue thickness compensation part 1104, tissue thickness compensation part 1120 can be at least partly by with glass transition temperature Material is constituted and can be modified by the way that material is transformed into glassy state.In one example, tissue thickness compensation part 1120 can The glass transition temperature of the material compositions more than or equal to tissue thickness compensation part 1120 is heated in baking oven (not shown) Degree but the temperature for being less than its melting temperature.As shown in figure 27, the mold 1126 including center sill 1128 can be used for by with lower section Formula forms slit 1122: center sill 1128 being inserted into tissue thickness compensation part when tissue thickness compensation part 1120 is in glassy state In 1120.When center sill 1128 is kept in insertion tissue thickness compensation part 1120, tissue thickness compensation part 1120 then can be made It is cool below the temperature of glass transition temperature.In some cases, its glassy state is in tissue thickness compensation part 1120 When, center sill 1128 can be removed from tissue thickness compensation part 1120.

In some cases, cooling medium can be used for being actively cooled tissue thickness compensation part 1120.In some cases, Fan can be used for when tissue thickness compensation part 1120 is in mold 1126 and/or tissue thickness compensation part 1120 Air stream is generated above tissue thickness compensation part 1120 after mold removal.In some cases, process of refrigerastion can be used for It has been removed from mold when tissue thickness compensation part 1120 is in mold 1126 and/or in tissue thickness compensation part 1120 Cools tissue thickness compensation part 1120 later.Center sill 1128 can be after tissue thickness compensation part 1120 changes and exits glassy state It is removed.Center sill 1128 can keep persistently being enough to allow tissue thickness compensation part 1120 in insertion tissue thickness compensation part 1120 Keep or at least substantially keep the period in space occupied by center sill 1128.In some examples, center sill 1128 can Such as it keeps being inserted into about 30 seconds to about 8 hours periods during the time in glassy state and/or is for example exiting Keep being inserted into about 30 seconds to about 8 hours periods after glassy state.In at least one example, center sill 1128 can be in Insertion is kept during the time of glassy state about 10 minutes and insertion about 10 minutes is kept after exiting glassy state.This public affairs It opens it is contemplated that for center sill 1128 to be maintained to the other times section in tissue thickness compensation part 1120.

Further described above, as shown in figure 28, the pressure applied during modification process by center sill 1128 Increased density of material can be generated at the part of tissue thickness compensation part 1,120 1130.Part 1130 can connect the first suturing part Divide 1124a and the second sutured portion 1124b, to provide additional stability for slit 1122.In some cases, mold 1126 It may include edge modifier, such as edge modifier 1132a and 1132b can modify tissue thickness's benefit during modification process Repay part 1120 to generate the edge 1134a and 1134b of modification respectively, as shown in figure 28.

Referring again to Figure 26 to Figure 28, it may be necessary to remove the material of significant quantity from tissue thickness compensation part 1120 to be formed Slit 1122.In such cases, center sill 1128 can be heated to the material compositions greater than tissue thickness compensation part 1120 Melting temperature temperature.After the center sill 1128 that will be heated is inserted into tissue thickness compensation part 1120, center sill 1128 It is fusible to pass through tissue thickness compensation part 1120, to form the sky for being used for slit 1122 in tissue thickness compensation part 1120 Between, as shown in figure 28.In certain circumstances, it may be necessary to gradually increase by center sill 1128 against tissue thickness compensation part 1120 The pressure of application is center sill 1128 to be gradually inserted in tissue thickness compensation part 1120.

In certain circumstances, it may be necessary to increase the density of material on one or more surfaces of tissue thickness compensation part.Such as Shown in Figure 29 to Figure 31, tissue thickness compensation part 1140 can be modified or varied, so that the surface of tissue thickness compensation part 1140 1142 may include the density of material higher than the remainder of tissue thickness compensation part 1140, in some cases, the higher material Material density can be realized after freeze drying.It is thick that tissue thickness compensation part 1140 can be similar in many aspects its hetero-organization described in other places Spend compensating part, such as tissue thickness compensation part 22020 (Fig. 9) and/or tissue thickness compensation part 1120 (Figure 26).Surface modifier 1144 may be used in the surface 1142 of thermal pressing process modification tissue thickness compensation part 1140, and the thermal pressing process is in many Aspect is similar to the thermal pressing process for modifying tissue thickness compensation part 1104 and/or tissue thickness compensation part 1120, as above It is described.For example, tissue thickness compensation part 1140 can at least partly be made of the material including glass transition temperature and can It is modified after being transformed into glassy state.

As described above, tissue thickness compensation part (such as tissue thickness compensation part 1140) can be transformed into glassy state, wherein should Tissue thickness compensation part is heated to the glass transition temperature of the material compositions more than or equal to tissue thickness compensation part 1140 Degree but the temperature for being less than its melting temperature.When tissue thickness compensation part 1140 is in glassy state, can be pressed against surface 1142 Surface modifier 1144.The pressure-compressible surface 1142 applied by surface modifier 1144, to increase the material on surface 1142 Expect density.The increase of density of material can be kept by surface 1142 in the following manner: surface 1142 being made to be cool below vitrifying The temperature of transition temperature.

It in some cases, can be for example in glassy state against the pressure that surface 1142 applies by surface modifier 1144 Time during maintain about 30 seconds to about 8 hours periods and/or for example maintained after exiting glassy state about 30 seconds To about 8 hours periods.In at least one example, pressure can maintain about 10 minutes during the time in glassy state And it is maintained after exiting glassy state about 10 minutes.The disclosure is susceptible to for maintaining by surface modifier 1144 against table The other times section for the pressure that face 1142 applies.

In some cases, fan can be used for when tissue thickness compensation part 1140 and modifying agent 1144 contact and/or Person has generated air above tissue thickness compensation part 1140 after the removal of modifying agent 1144 in tissue thickness compensation part 1140 Stream.In some cases, process of refrigerastion can be used for when tissue thickness compensation part 1140 and modifying agent 1144 contact and/or In tissue thickness compensation part 1140 from cools tissue thickness compensation part 1140 after the removal of modifying agent 1144.It is mended in tissue thickness It repays the transformation of part 1140 to exit after glassy state, in all cases, surface modifier 1144 can be with tissue thickness compensation part 1140 It is disengaged.In some cases, surface modifier 1144 may include heating element, which can be used for surface 1142 Temperature increase to the material compositions more than or equal to tissue thickness compensation part 1140 glass transition temperature temperature, such as It is upper described.

Referring again to Figure 30, surface modifier 1144 may include flat or at least substantially flat contact surface 1146 For contacting such as surface 1142.In other cases, contact surface 1146 can have various textures, can such as modify The protrusion in the surface 1142 of tissue thickness compensation part 1140 is extended to during journey.In some cases, surface modifier 1144 It can be used for pressure is applied to the table of tissue thickness compensation part 1140 before tissue thickness compensation part 1140 is converted to glassy state On face 1142.In some cases, surface modifier 1144 can be heated to reach glassy state in tissue thickness compensation part 1140 When, change or be cooled to when tissue thickness compensation part 1140 is in glassy state, and/or in tissue thickness compensation part 1140 Apply pressure to surface 1142 when glassy state temperature below.In some cases, such as in tissue thickness compensation part 1140 When temperature is gradually increased so that tissue thickness compensation part 1140 towards glassy transition, surface is applied to by surface modifier 1144 1142 pressure can gradually increase towards threshold value.In some cases, when tissue thickness compensation part 1140 exits glassy state, in group It knits thickness compensation part 1140 to exit before glassy state, and/or after tissue thickness compensation part 1140 exits glassy state, applies The pressure for being added to surface 1142 can be removed, gradually remove or at least partly reduce.

In some cases, tissue thickness compensation part 1140 can be modified or varied be include epidermis or dense outer layer.? In some cases, gained epidermis or dense outer layer may include texture, such as may extend into the surface of tissue thickness compensation part 1140 Protrusion in 1142.In some cases, the contact surface 1146 of surface modifier 1144 can be heated to more than or equal to group Knit the temperature of the melting temperature of the material compositions of thickness compensation part 1140.Surface modifier 1144 and/or tissue thickness's compensation Part 1140 is movable so that the surface 1142 of tissue thickness compensation part 1140 and the heated contact surface of surface modifier 1144 1146 contacts, so that surface 1142 be made to melt or at least substantially melt.Surface modifier 1144 and tissue thickness compensation part 1140 is then separable to allow the surface 1142 modified to be cooled to its melting temperature hereinafter, this can be by epidermis or dense outer layer shape At in tissue thickness compensation part 1140.

In some cases, the contact surface 1146 of surface modifier 1144 can be added before contacting with surface 1142 Heat.In other cases, the contact surface 1146 of surface modifier 1144 can be heated after contacting with surface 1142.

In some cases, the contact surface 1146 of surface modifier 1144 can be kept and tissue thickness compensation part 1140 Surface 1142 contacts the period for being enough to flow into surface 1142 in required geometry.Such period can be at for example, about 30 seconds To in the range of about 8 hours, the disclosure is contemplated that other times section.Such period can be enough local influence and/or It melts the material of tissue thickness compensation part 1140 and enables its flow into new geometry.As described herein, such new geometry Shape can be provided by the tool for manufacturing tissue thickness compensation part 1140.

In some cases, tissue can be made thick before separating surface modifier 1144 with tissue thickness compensation part 1140 The surface 1142 of degree compensating part 1140 is cooling or is actively cooled the temperature of the melting temperature lower than tissue thickness compensation part 1140 Degree.In other cases, tissue thickness can be made to mend after separating surface modifier 1144 with tissue thickness compensation part 1140 It repays the cooling of surface 1142 of part 1140 or is actively cooled the temperature of the melting temperature lower than tissue thickness compensation part 1140.

Further described above, the surface 1142 of modification may include density, such as the density ratio tissue thickness is mended Repay the remainder of part 1140 density about 10%, than tissue thickness compensation part 1140 remainder density about 20%, than the density about 30% of the remainder of tissue thickness compensation part 1140, than the residue of tissue thickness compensation part 1140 Partial density about 40%, than tissue thickness compensation part 1140 remainder density about 50%, than tissue thickness mend Repay the remainder of part 1140 density about 60%, than tissue thickness compensation part 1140 remainder density about 70%, than the density about 80% of the remainder of tissue thickness compensation part 1140, than the residue of tissue thickness compensation part 1140 The density about 100% of partial density about 90% and/or the remainder than tissue thickness compensation part 1140.? In various situations, surface 1142 may include density, such as the density is greater than the close of the remainder of tissue thickness compensation part 1140 Degree, and twice of the density less than the remainder of tissue thickness compensation part 1140.In all cases, the surface of modification 1142 may include density, such as the density is greater than twice of the density of the remainder of tissue thickness compensation part 1140.

Referring now to Figure 32 to Figure 34, tissue thickness compensation part 1150 can be modified to include at least partly extending through Cross multiple holes 1152 of tissue thickness compensation part 1150.Tissue thickness compensation part 1150 can be similar to described herein in many aspects Other tissue thickness compensation parts, such as tissue thickness compensation part 20220 (Fig. 6).Such as compensating part 20220, compensating part 1150 It can be used together with storehouse component 20200 (Fig. 6), and hole 1152 can be similar in many aspects and at least partly extend through group Knit the mesopore 20224 of thickness compensation part 20220.For example, such as hole 20224, when tissue thickness compensation part 1150 is assembled with storehouse When component 20200, hole 1152 can be aligned with corresponding nail leg 20232 (Fig. 7) so that nail leg 20232 can nail leg 20232 never Percussion configuration moves across the mesopore 1152 in tissue thickness compensation part 1150 when moving to percussion configuration, such as above in more detail Ground description.

Further described above, tradition can be used in tissue thickness compensation part 1150 referring again to Figure 32 to Figure 34 It is prepared by freeze drying technology and/or any other suitable technology.In some cases, with the polymer of glass transition temperature (such as polylactic acid (PLA) and/or polyglycolic acid (PGA)) is dissolvable in water to form solution in organic solvent, which can be frozen It does to generate tissue thickness compensation part 1150.In addition, tissue thickness compensation part 1150 can be after freeze drying using thermal pressing process Modification, the thermal pressing process are similar in many aspects for modifying tissue thickness compensation part 1104, tissue thickness compensation part 1120 and/or tissue thickness compensation part 1140 thermal pressing process, as described above.Once for example, tissue thickness compensation part 1150 It is transformed into glassy state, tissue thickness compensation part 1150 can be modified to include hole 1152.

As described above, tissue thickness compensation part (such as tissue thickness compensation part 1150) can be by baking oven (not shown) It is heated to the glass transition temperature of the material compositions more than or equal to tissue thickness compensation part 1150 but is less than its melting temperature The temperature of degree and be transformed into glassy state.Mold 1154 (such as needle 1156) including multiple columns, dowel, pin and/or protrusion is available In formation hole 1152 in the following manner: needle 1156 being inserted into tissue thickness when tissue thickness compensation part 1150 is in glassy state In compensating part 1150.When needle 1156 is kept in insertion tissue thickness compensation part 1150, tissue thickness compensation part then can be made 1150 are cool below the temperature of glass transition temperature.In some cases, glass is in tissue thickness compensation part 1150 When state, needle 1156 can be removed from tissue thickness compensation part 1150.In some cases, fan can be used in tissue thickness compensation part 1150 are organizing thickness with when the engagement of needle 1156 and/or after tissue thickness compensation part 1150 is disengaged with needle 1156 Air stream is generated above degree compensating part 1150.In some cases, process of refrigerastion can be used for tissue thickness compensation part 1150 with Cools tissue thickness is mended when needle 1156 engages and/or after tissue thickness compensation part 1150 is disengaged with needle 1156 Repay part 1150.In all cases, needle 1156 can be removed after tissue thickness compensation part 1150 changes and exits glassy state.Needle 1156 can keep persistently being enough to allow the holding of tissue thickness compensation part 1150 or at least base in insertion tissue thickness compensation part 1150 Keep limiting the period in the space in the hole 1152 occupied by needle 1156 in sheet.

In some examples, needle 1156 for example can keep insertion about 30 seconds to about 8 small during the time in glassy state When period and/or keep being inserted into about 30 seconds to about 8 hours periods for example after exiting glassy state.At least In one example, needle 1156 can in glassy state time during keep insertion about 10 minutes and exit glassy state it Insertion about 10 minutes is kept afterwards.The disclosure is susceptible to other for maintaining needle 1156 to be inserted into tissue thickness compensation part 1150 Period.

In some cases, before glassy state is exited in the transformation of tissue thickness compensation part 1150, needle 1156 can be thick from tissue Compensating part 1150 is spent to remove.In other cases, needle 1156 can be removed gradually as time goes by.For example, being mended in tissue thickness It repays the transformation of part 1150 to exit before glassy state, needle 1156 can partly be removed from tissue thickness compensation part 1150.In tissue thickness The transformation of compensating part 1150 is exited after glassy state, then needle 1156 can be removed completely from tissue thickness compensation part 1150.Reader will Understand, the depth that needle 1156 is inserted into tissue thickness compensation part 1150 is bigger, pair that can be formed in tissue thickness compensation part 1150 Answer the depth in hole 1152 bigger.

Referring again to Figure 32 to Figure 34, in some cases, needle 1156 can be heated to be mended more than or equal to tissue thickness Repay the temperature of the melting temperature of the material compositions of part 1150.In addition, needle 1156 can be inserted into tissue thickness compensation part 1150 By melting or at least partly to melt the region of the reception needle 1156 across tissue thickness compensation part 1150 and form hole 1152.In all cases, needle 1156 can be heated before being inserted into tissue thickness compensation part 1150.In all cases, Needle 1156 can be heated later in insertion tissue thickness compensation part 1150.In all cases, needle 1156 can be with needle 1156 It is inserted into tissue thickness compensation part 1150 and is gradually heated up.

In some cases, needle 1156 can remain positioned in tissue thickness compensation part 1150 and be enough to allow tissue thick for one section Time in geometry needed for spending the melted material inflow of compensating part 1150.Such period can be at for example, about 30 seconds to about 8 In the range of hour, the disclosure is contemplated that other times section.Such period can be enough local influence and/or melting group It knits the material of thickness compensation part 1150 and enables its flow into new geometry.As described herein, such new geometry can By the tool regulation for manufacturing tissue thickness compensation part 1150.

In some cases, tissue thickness compensation part can be made before separating needle 1156 with tissue thickness compensation part 1150 1150 temperature that are cooling or being actively cooled the melting temperature lower than tissue thickness compensation part 1150.In other cases, may be used Make tissue thickness compensation part 1150 cooling after separating needle 1156 with tissue thickness compensation part 1150 or is actively cooled Lower than the temperature of the melting temperature of tissue thickness compensation part 1150.

Referring again to Figure 32 to Figure 34, needle 1156 can be arranged the row longitudinally extended along the length of mold 1154, should Row can correspond to the staple in nail bin (such as nail bin groupware 20200 (Fig. 6)).For example, as shown in figure 33, needle 1156 can be arranged It at six rows, is configured to form six rounds 1152, which is configured to receive six nails 20230 (Fig. 7).In some cases, as shown in figure 33, the row of needle 1156 can be arranged to two groups, and described two groups are spaced apart and by structure It causes to receive in two parts 1158 and 1160 of tissue thickness compensation part 1150, be divided to be formed by middle section 1162 From two groups of holes 1152.When tissue thickness compensation part 1150 is assembled with nail bin groupware 20200, middle section 1162 can at least portion It is located in above storehouse cutter slit 22015 (Fig. 6) with dividing.In use, firing member 10052 (Figure 10) can be promoted towards distal side to push away Dynamic nail leg 20232 (Fig. 8) passes through the hole 1152 in part 1158 and 1160 and promotes cut portion 10053 (Figure 10) with crosscutting Middle section 1162 and separate section 1158 and 1160.

Referring again to Figure 32 to Figure 34, hole 1152 be configured in tissue thickness compensation part 1150 extend and It terminates at the certain depth in tissue thickness compensation part 1150.Hole 1152 may include uniform depth, as shown in figure 34.At it In the case of him, hole 1152 may include different depth (not shown).For example, the first round 1152 may include the first depth, and the Two rounds 1152 may include the second depth different from the first depth, and third round 1152 may include be different from the first depth and The third depth of second depth.The depth in hole 1152 can be determined at least partially through the height of corresponding needle 1156.For example, packet Include the first row needle 1156 of the first height and include greater than the first height the second height second row needle 1156 can be formed including First round 1152 of the first depth and include greater than the first depth the second depth the second round 1152.

Referring again to Figure 32 to Figure 34, needle 1156 is configured to for the path for being used for hole 1152 to be limited to tissue thickness It spends in compensating part 1150.In some cases, needle 1156 can along perpendicular to and/or be substantially perpendicular to the mould of mold 1154 The axis for having surface 1164 extends, as shown in figure 33.Needle 1156 is inserted into tissue thickness compensation part 1150 and maintains mold simultaneously Parallel relation between surface 1164 and the surface of tissue thickness compensation part 1,150 1166 can lead to be compensated relative to tissue thickness The surface 1166 of part 1150 limits the vertical and/or substantially vertical path for being used for hole 1152, as shown in figure 34.In other feelings Under condition, needle 1156 can be extended with oblique angle (not shown) from die surface 1164 and/or needle 1156 is to tissue thickness compensation part Insertion path in 1150 can be at an angle of, and be used so that needle 1156 can be limited relative to the surface 1166 of tissue thickness compensation part 1150 Non-perpendicular path in hole 1152.In some cases, one group of needle 1156 can be parallel to each other and/or be substantially put down each other Row can be parallel to each other so as to cause one group of hole 1152 and/or be substantially parallel to each other as shown in figure 33, as shown in figure 24. In other cases, although it is not shown, but one group of nonparallel needle can extend from die surface 1164 and can be in insertion tissue Nonparallel hole is generated when in thickness compensation part 1150.In some cases, needle 1156 is configured in tissue thickness Hole is formed in compensating part 1150, which may include the path of the curved path in part and/or partial linear.Example Such as, needle 1156 can the curved path in part from die surface 1164 extend and can be inserted into tissue thickness compensation part 1150 To form hole in tissue thickness compensation part 1150 using the curved path in corresponding part.

Referring again to Figure 32 to Figure 34, some or all of needle 1156 may include blunt distal end 1168, such as Figure 33 It is shown.In other cases, some or all of needle 1156 may include sharp keen distal end (not shown).In needle 1156 Some or all may include cylindrical or at least substantially cylindrical shape, for example, as shown in figure 33.The disclosure is also contemplated that To other shapes.In all cases, one or more of the needle 1156 extended from die surface 1164 may not be inserted Enter the whole thickness across tissue thickness compensation part 1150.In some cases, from the needle 1156 that die surface 1164 extends One or more may be inserted into across the whole thickness of tissue thickness compensation part 1150 with formed extend through tissue thickness Spend opening and/or the hole of the whole thickness of compensating part 1150.In some cases, from the needle 1156 that die surface 1164 extends One or more be insertable through tissue thickness compensation part 1150 the first side and pass through such as tissue thickness compensation part 1150 second side that can be opposite with the first side is left.In some cases, one or more of needle 1156 may include being greater than The length of the whole thickness of tissue thickness compensation part 1150 is to be conducive to one or more needles 1156 being inserted through tissue thickness The whole thickness of compensating part 1150.

Referring now to Figure 35 to Figure 37, it may be necessary to reset the size of tissue thickness compensation part.For example, tissue One or more sizes of thickness compensation part can be adjusted to that the size corresponding to nail bin to assemble in tissue thickness compensation part Have and provides preferably cooperation to nail bin when nail bin.In some cases, tissue thickness compensation part 1170 can by by its height from First height H1 as shown in figure 35 changes into the second height H2 as shown in figure 36 to reset size.Tissue thickness Compensating part 1170 can be similar to other tissue thickness compensation parts as described herein, such as tissue thickness compensation part in many aspects 22020 (Fig. 9), tissue thickness compensation part 1140 (Figure 29) and/or tissue thickness compensation part 1150 (Figure 32).For example, as mended Part 22020 is repaid, compensating part 1170 can be used together with end effector 22090 (Fig. 9).

In all cases, referring again to Figure 35 to Figure 37, traditional freeze drying technology is can be used in tissue thickness compensation part 1170 And/or prepared by any other suitable technology.In some cases, such as hot pressing can be used in tissue thickness compensation part 1170 Process and mold 1172 reset size, as shown in figure 37.Mold 1172 may include being configured to reception group The adjustment means 1176 knitting the receiver 1174 of thickness compensation part 1170 and capable of being inserted partially into receiver 1174.Work as group When knitting thickness compensation part 1170 and being transformed into glassy state, tissue thickness compensation part 1170 can be reset size.At one In embodiment, tissue thickness compensation part 1170 can be heated to be greater than or equal to tissue thickness compensation part in baking oven (not shown) The glass transition temperature of 1170 material compositions but the temperature for being less than its melting temperature.In another embodiment, it connects It receives device 1174 and/or adjustment means 1176 may include the heating unit for tissue thickness compensation part 1170 to be converted to glassy state Part.Then adjustment means 1176 can be inserted into distance H3 in receiver 1174, such as shown in figure 37, to compress tissue thickness Compensating part 1170 and its height is reduced to the second height H2 from the first height H1.It in some cases, can be in tissue thickness Compensating part 1170 enters before glassy state or just when tissue thickness compensation part 1170 enters glassy state by adjustment means In 1176 insertion receivers 1174.Adjustment means 1176 can be kept against tissue thickness compensation part 1170 to compress tissue thickness's benefit Part 1170 is repaid persistently to be enough that tissue thickness compensation part 1170 is allowed to keep or at least substantially keep the period of the second height H2, As shown in figure 36.When under the compression from adjustment means 1176, then tissue thickness compensation part 1170 can be made to be cooled to Lower than the temperature of glass transition temperature.After glassy state is exited in the transformation of tissue thickness compensation part 1170, adjustment means 1176 It can bounce back.In some cases, before tissue thickness compensation part 1170 exits glassy state, adjustment means 1176 can bounce back.? In some cases, above-mentioned reset size process can be used for changing another size of tissue thickness compensation part 1170, Such as length or width of tissue thickness compensation part 1170.In some cases, these sizes can be modified or in order simultaneously Modification.

In some examples, the compression from adjustment means 1176 can be maintained for example about during the time in glassy state 30 seconds to about 8 hours periods and/or about 30 seconds to about 8 hours time is for example maintained after exiting glassy state Section.In at least one example, the compression from adjustment means 1176 can maintain about 10 during the time in glassy state Minute and maintained after exiting glassy state about 10 minutes.The disclosure is contemplated that for maintaining to be supported by adjustment means 1176 The period of the compression applied by tissue thickness compensation part 1170.

In some cases, adjustment means 1176 can be used for before tissue thickness compensation part 1170 is converted to glassy state inciting somebody to action Pressure is applied in tissue thickness compensation part 1170.In some cases, adjustment means 1176 can be in tissue thickness compensation part 1170 when being heated to reach glassy state, when tissue thickness compensation part 1170 is in glassy state, and/or in tissue thickness Apply pressure to tissue thickness compensation part 1170 when compensating part 1170 changes or be cooled to glassy state temperature below.In certain feelings Under condition, for example, tissue thickness compensation part 1170 temperature gradually towards glassy transition when, be applied to tissue thickness compensation part 1170 pressure can gradually increase towards threshold value.In some cases, when tissue thickness compensation part 1170 exits glassy state, in group It knits thickness compensation part 1170 to exit before glassy state, and/or after tissue thickness compensation part 1170 exits glassy state, applies The pressure for being added to tissue thickness compensation part 1170 can be removed, gradually remove or at least partly reduce.

It will be appreciate that the different molds (such as mold 1144,1154 and/or 1172) for during above-mentioned modification are Illustrative examples.Other mold design and configuration can also be used for manipulating tissue thickness compensation part in many ways.In addition, manipulation group It knits power involved in thickness compensation part and does not need only compressing force.For example, pulling force can also be used for with those described above The shape and/or size that the similar mode of mode modifies tissue thickness compensation part, resets tissue thickness compensation part.Example Such as, it is possible to use pulling force carrys out stretch tissue thickness compensation part 1170 so that its height is reduced to second from the first height H1 (Figure 35) Height H2 (Figure 36), for example, using the modification process for being similar to above-mentioned modification process in many aspects.In some cases, it draws The combination of power and compressing force can be used for the manipulating tissue thickness compensation part during modification process.

Referring again to Figure 35 to Figure 37, it may be necessary to modify the porosity of tissue thickness compensation part to make in surgical operation With.Tissue thickness compensation part may include for example porous open celled foam and/or porous closed-cell foam.Traditional freeze drying technology can be right The porosity of tissue thickness compensation part provides certain control, but it is not easily possible to repeat and may need can not for such control It additional is fine-tuned by what traditional freeze drying technology obtained.As shown in FIG. 35 to 37, for example above-mentioned modification process can be used The height of tissue thickness compensation part 1170 is set to become the second height H2 (Figure 36) from the first height H1 (Figure 35).In addition, can also make The porosity of tissue thickness compensation part 1170 is modified with identical and/or similar modification process.For example, tissue thickness compensation part 1170 can have the first porosity (Figure 35) before modification process, and have the second porosity after completing modification process (Figure 36), as described above.The change of porosity can be at least partially attributed to during above-mentioned modification process by adjustment means 1176 are applied to the compressing force and/or energy of tissue thickness compensation part 1170.

Further described above, tissue thickness compensation part 1170 may include multiple holes 1180.For example, as upper State modification process as a result, some or all of hole 1180 can change in terms of position, size and/or shape.Example Such as, one or more of hole 1180 can include spherical or made of substantially spherical shape before modification process, as modification Process as a result, the shape can be changed to ellipse or generally elliptical shape.In at least one example, hole One or more of 1180 can include first size before modification process and the result as modification process includes difference In the second size of first size.In some cases, as described in greater detail below, porosity change can be limited to tissue thickness Spend the one or more regions or area of compensating part 1170.

In addition, in some cases, the change of the porosity of tissue thickness compensation part 1170 can be mended along with tissue thickness Repay the change of the density of part 1170.In other words, when adjustment means 1176 are promoted against tissue thickness compensation part 1170, compression Power can reduce space occupied by tissue thickness compensation part 1170, redistribute so as to cause material and/or hole, this can cause The increase of the density of tissue thickness compensation part 1170 and/or the reduction of its porosity.In some cases, it is as follows in more detail Description, density change the one or more regions or area that can be limited to tissue thickness compensation part 1170.

Further described above, the porosity of tissue thickness compensation part 1170 and/or the change of density can cause The change of the flexible ratio of tissue thickness compensation part 1170.When tissue thickness compensation part is caught against by following closely such as 20230 (Fig. 8) of nail When the tissue deployment obtained, the flexible ratio of tissue thickness compensation part can influence its ability for compensating tissue thickness, such as above more in detail Carefully describe.It is captured against by following closely with tissue thickness compensation part in addition, the flexible ratio of tissue thickness compensation part can also influence it Tissue apply stressed ability.In other words, the variation of the flexible ratio of tissue thickness compensation part is changeable by tissue thickness Compensating part is against the tissue pressure applied by nail capture.Due to histological types certain pressure can be made it is more positive Response, so can be advantageous to the precise controlling of the flexible ratio of tissue thickness compensation part.

As shown in FIG. 35 to 37, tissue thickness compensation part 1170 may include the first flexible ratio (Figure 35), first bullet Sex rate can be used above-mentioned modification process change or be revised as the second flexible ratio (Figure 36) different from the first flexible ratio.Example Such as, as described above, adjustment means 1176 can be against tissue thickness compensation part when tissue thickness compensation part 1170 is in glassy state 1170 promote.In response, tissue thickness compensation part 1170 can be compressed, this leads to the elastic ratio of tissue thickness compensation part 1170 The change of rate.Adjustment means 1176, which are positively retained at, promotes in position one section to be enough to allow tissue thickness compensation part 1170 to keep or extremely It is kept substantially the time of the variation of flexible ratio less.In addition, tissue thickness compensation part 1170 can be made to be cooled to its combination of materials The glass transition temperature of object hereinafter, maintain the pressure applied by adjustment means 1176 against tissue thickness compensation part 1170 simultaneously Power.

In some cases, adjustment means 1176 can be compensated for example during the time in glassy state against tissue thickness Part 1170 maintain promote position in for about 30 seconds to about 8 hours period and/or for example exit glassy state it Afterwards for about 30 seconds to about 8 hours periods.In at least one example, adjustment means 1176 for example can be in glassy state Time during maintain to promote in position against tissue thickness compensation part 1170 and continue about 10 minutes and exiting glass Continue about 10 minutes after state.The disclosure is contemplated that for tieing up adjustment means 1176 against tissue thickness compensation part 1170 It holds and is promoting the other times section in position.

In some cases, adjustment means 1176 can be used for before tissue thickness compensation part 1170 is converted to glassy state inciting somebody to action Pressure is applied to the flexible ratio for changing tissue thickness compensation part 1170 in tissue thickness compensation part 1170.In certain situations Under, adjustment means 1176 can be when tissue thickness compensation part 1170 be heated to reach glassy state, in tissue thickness compensation part 1170 when being in glassy state, and/or when tissue thickness compensation part 1170 changes or be cooled to glassy state temperature below Apply pressure to tissue thickness compensation part 1170.In some cases, for example, tissue thickness compensation part 1170 temperature gradually When increasing so that tissue thickness compensation part 1170 is towards glassy transition, the pressure for being applied to tissue thickness compensation part 1170 can be gradually Increase towards threshold value.In some cases, when tissue thickness compensation part 1170 exits glassy state, in tissue thickness compensation part 1170 It exits before glassy state, and/or after tissue thickness compensation part 1170 exits glassy state, is applied to tissue thickness's compensation The pressure of part 1170 can be removed, gradually remove or at least partly reduce.

Referring again to Figure 35 to Figure 40, tissue thickness compensation part 1170 can be used traditional freeze drying technology and/or any other Suitable technology is manufactured with natural flexible ratio.As described above, the flexible ratio of tissue thickness compensation part 1170 can influence It applies stressed ability with the tissue that tissue thickness compensation part 1170 captures against by following closely.Above-mentioned modification process can be used for adjusting The natural elasticity ratio of tissue thickness compensation part 1170 is to adjust it against the group captured by nail tissue thickness compensation part 1170 It knits and applies stressed ability.In some cases, the natural elasticity ratio of tissue thickness compensation part 1170 can be at point A (Figure 40) The first flexible ratio increase to the second flexible ratio, second flexible ratio include and up at point B (Figure 40) most Big flexible ratio.In some cases, such increase of the flexible ratio of tissue thickness compensation part 1170 can be in the following manner It realizes: when tissue thickness compensation part 1170 is in glassy state, being applied using adjustment means 1176 to tissue thickness compensation part 1170 Compressive forces, as explained during above-mentioned modification.As shown in figure 40, point B represents the maximum of tissue thickness compensation part 1170 Elastic rate.Therefore, being applied to tissue thickness compensation part 1170 in point B by adjustment means 1176 is more than appointing for threshold compression What additional compression can lead to the reduction of the flexible ratio for the tissue thickness compensation part 1170 modified.For example, as shown in figure 40, Flexible ratio at point C is less than the flexible ratio at point B, even if being applied to tissue thickness in point C by adjustment means 1176 The compressing force of compensating part 1170 is greater than the compressing force applied at point B.

As described above, one or more processes can be used for influencing in conjunction with such as fastener cartridge and/or reuse surgical fasteners tool The flexible ratio of the material used and/or any other characteristic.The flexible ratio of material and/or any other characteristic can be entire Change during modification.In some cases, such change may be gradual, and in other cases, which may be Unexpected.In all cases, the flexible ratio that one or more of the step of modifying process can lead to material increases, and one A or multiple steps can lead to the reduction of the flexible ratio of material.Finally, the initial elasticity ratio before modification process starts When being completed compared between the subsequent flexible ratio after modification process, the net change of flexible ratio can measure.Various In the case of, after being heated in material and then having cooled down, material can have the flexible ratio of change.

In certain circumstances, it may be necessary to which the one or more application during above-mentioned modification is compensated in tissue thickness Part.For example, the first modification process can be used for modifying the porosity of tissue thickness compensation part, such as compensated above in relation to tissue thickness Described in part 1170.The second modification process after first modification process can be used for changing the surface of tissue thickness compensation part, as above Text is relative to described in tissue thickness compensation part 1140.In addition, third modification process can be used for for tissue thickness compensation part being revised as Longitudinal slit including being similar to the longitudinal slit 1122 of tissue thickness compensation part 1120.During another the 4th modification, Tissue thickness compensation part can be modified to include the hole similar to the hole 1152 of tissue thickness compensation part 1150.It will be appreciate that Some in above-mentioned modification can combine during single modification or grouping.For example, mold is designed to include mold 1154 Needle 1156 and mold 1126 center sill 1128.The disclosure is contemplated that other modification arrangements.

Referring now to Figure 38 and Figure 39, the one or more in above-mentioned modification process can be used that tissue thickness compensation part is all As tissue thickness compensation part 1190 be altered or modified be include the part with different flexible ratios, porosity and/or density.? In some cases, the one or more in above-mentioned modification process can be used to be revised as tissue thickness compensation part 1190 to include gradient Pore morphology is (that is, the size of fine pore gradually increases into macropore across the thickness of tissue thickness compensation part 1190 in one direction Gap).Such form is even more ideal for tissue growth or hemostasis behavior.In addition, gradient can also be with the bio-absorbable of variation Section is combined.Short-term absorption profile may be more suitable for realizing hemostasis, and Long-term absorption section may be implemented preferably to organize to be cured Close and it is non-leakage.

Referring again to Figure 38 and Figure 39, tissue thickness compensation part 1190 can have the residue with tissue thickness compensation part 1196 The different one or more region geometry shapes in part.For example, as shown in figure 38, tissue thickness compensation part 1190 may include one Or multiple protrusions, such as protrusion 1196.In addition, tissue thickness compensation part 1190 may include across including one or more Uniform or at least substantially uniform first flexible ratio of the tissue thickness compensation part 1190 of a region geometry shape, first Porosity and/or the first density, as shown in figure 38.In some cases, one or more of above-mentioned modification process can be used Tissue thickness compensation part 1190 is altered or modified one or more region geometry shapes are altered or modified and/or cause Such as the part of first flexible ratio, the first porosity and/or the first density changes.The tissue thickness compensation part 1190 of modification can Region including one or more modification, the region of the modification have and the region of other modifications and/or tissue thickness First flexible ratio of the remainder of compensating part 1190, the first porosity and/or the respectively different flexible ratio of the first density, Porosity and/or density.In some cases, it is several to can correspond to one or more regions for the region of gained one or more modification What shape.For example, as shown in figure 39, tissue thickness compensation part 1190 can be changed or modified for protrusion 1196 it is horizontal or It is at least substantially horizontal, and form for example flat or at least substantially flat surface 1198.The tissue thickness of modification compensates Part 1190 may include first part 1192 with the first flexible ratio, the first porosity and/or the first density and have point It Bu Tongyu not the first flexible ratio, the second flexible ratio of the first porosity and/or the first density, the second porosity and/or The second part 1194 of two density.Second part 1194 can correspond to protrusion 1196, and can lead to and protrusion 1196 is horizontal or at least substantially horizontal, to form for example flat or at least substantially flat surface 1198.In some aspects, The geometry reflection, matching or similar in tissue thickness of protrusion 1196 before the modification of tissue thickness compensation part 1190 The geometry of second part 1194 after compensating part 1190 is modified.

Referring again to Figure 37 to Figure 39, the mode that can be similar to tissue thickness compensation part 1170 is changed using mold 1172 Become or modify tissue thickness compensation part 1190.For example, tissue thickness compensation part 1190 can be heated to be greater than in receiver 1174 Or equal to tissue thickness compensation part 1190 material compositions glass transition temperature but be less than its melting temperature temperature.? In some cases, when tissue thickness compensation part 1190 is in glassy state, adjustment means 1176 can abutment projection points 1196 push away Into to compress protrusion 1196 and rearrange its geometry to form second part 1194, as shown in figure 39.It is right It is described further above, the compression that adjustment means 1176 are configured to be maintained against protrusion 1196 continues foot To allow tissue thickness compensation part 1190 to keep or at least substantially keep the period of the modification applied by adjustment means 1176. When under the compression from adjustment means 1176, tissue thickness compensation part 1190 can be made cooling or can be actively cooled low In the temperature of its glass transition temperature.After glassy state is exited in the transformation of tissue thickness compensation part 1190, adjustment means 1190 It can bounce back.Tissue thickness compensation part 1190 can keep or at least substantially keep second part 1194, as shown in figure 39.Certain In the case of, adjustment means 1176 can be compensated when tissue thickness compensation part 1190 is heated to reach glassy state in tissue thickness When part 1190 is in glassy state, and/or in the transformation of tissue thickness compensation part 1190 or it is cooled to glassy state temperature below When pressure is applied on protrusion 1196.In some cases, for example, tissue thickness compensation part 1190 temperature gradually When increasing so that tissue thickness compensation part 1190 is towards glassy transition, it is applied to the protrusion of tissue thickness compensation part 1190 1196 pressure can gradually increase towards threshold value.In some cases, when tissue thickness compensation part 1190 exits glassy state, in group It knits thickness compensation part 1190 to exit before glassy state, and/or after tissue thickness compensation part 1190 exits glassy state, applies The pressure for being added to the protrusion 1196 of tissue thickness compensation part 1190 can be removed, gradually remove or at least partly reduce.

Referring now to Figure 41 to Figure 43, traditional freeze drying technology and/or any other suitable technology can be used to prepare group Knit thickness compensation part, such as tissue thickness compensation part 1200.In addition, tissue thickness compensation part 1200 can be modified or varied with In such as surgical operation.Tissue thickness compensation part 1200 can be similar to other tissue thickness compensation parts in many aspects, such as Tissue thickness compensation part 22020 (Fig. 9) and/or tissue thickness compensation part 1120 (Figure 26).For example, such as tissue thickness compensation part 22020, tissue thickness compensation part 1200 can be used together with end effector 22090.In addition, as shown in Figure 41 to Figure 43, group Knitting thickness compensation part 1200 can be modified to include longitudinal slit 1202, which can will be used for such as cutter slit 22025 The tissue thickness compensation part cutter track diameter of cut portion 10053 is limited to the first sutured portion 1204a and the second sutured portion 1204b Between.It is compensated in addition, the first sutured portion 1204a and the second sutured portion 1204b can be similar in many aspects tissue thickness The the first sutured portion 22021a (Fig. 9) and the second sutured portion 22021b (Fig. 9) of part 22020.In addition, slit 1202 can be by structure Cause that the first sutured portion 1204a and the second sutured portion 1204b can be releasably attached so that with end effector 22090 when being used together, and cut portion 10053 can be advanced through slit 1202 with crosscutting slit 1202 and by first towards distal side Sutured portion 1204a and the second sutured portion 1204b separation.

Referring again to Figure 41 to Figure 43, tissue thickness compensation part 1200 can be executed being assembled with end effector such as end It is modified before device 22090 (Fig. 9).Alternatively, tissue thickness compensation part 1200 can be after it be assembled with end effector It is modified.As described above, traditional freeze drying technology and/or any other suitable technology can be used for tissue thickness compensation part 1200 Preparation.Space creator 1206 can be used for modifying tissue thickness compensation part 1200 in thermal pressing process, such as Figure 41 to Figure 43 institute Show.For example, space creator 1206 can be heated to the molten of the material compositions more than or equal to tissue thickness compensation part 1200 Melt the temperature of temperature.Then space creator 1206 can be aligned with tissue thickness compensation part 1200 and be inserted into tissue thickness's compensation In part, to form longitudinal slit 1202.The fusible tissue thickness compensation part 1200 that passes through of space creator 1206 is for longitudinal Slit 1202 creates space.Space creator 1206 can return after reaching the required depth in tissue thickness compensation part 1200 Contracting.In some cases, thermal pressing process can be mended by reinserting the space creator 1206 of heating across tissue thickness Part 1200 is repaid to repeat to widen the space for being directed to longitudinal slit 1202 and creating.

Referring again to Figure 41 to Figure 43, space creator 1206 may include hot wire.For example, space creator 1206 can Including thin, tension the metal wire made of such as nichrome or stainless steel, or it is pre-formed as the thicker of required shape Line.Hot wire can be by being resistively heated to required temperature.In space, the hot wire of creator 1206 is mended across tissue thickness When repaying the material of part 1200, the heat from hot wire just can be such that material evaporates before contact.In some cases, hot Wire can have cylindrical or substantially cylindrical shape, as shown in figure 42.The depth of longitudinal slit 1202 can be partly The insertion depth of tissue thickness compensation part 1200 is passed through depending on space creator 1206, and the width of longitudinal slit 1202 can It is partly dependent on the diameter of the hot wire of space creator 1206.

In some cases, space creator 1206 can be inserted partially into the whole thickness across tissue thickness compensation part. In some cases, the whole thickness that space creator 1206 can be inserted completely through tissue thickness compensation part 1200 is prolonged with being formed Extend through opening, hole and/or the slit of the whole thickness of tissue thickness compensation part 1200.In some cases, space creator 1206 be insertable through the first side of tissue thickness compensation part 1200 and pass through such as tissue thickness compensation part 1200 can be with The opposite second side in first side is left.

Disclosed herein is many techniques, the technology utilization thermal energy modifies tissue thickness compensation part.Such technique can Referred to as felt technique.In some cases, felt technique, which can also be used to tissue thickness compensation part, applies compressing force and/or drawing Power.In other cases, felt technique, which can not be utilized to tissue thickness compensation part, applies compressing force and/or pulling force.Any In the case of, felt technique disclosed herein can also be used for for example modifying and appropriately implanting layer and/or backing material.

In all cases, tissue thickness compensation part component may include polymer composition.Polymer composition may include One or more synthetic polymers and/or one or more non-synthetic polymers.Synthetic polymer may include the absorbable of synthesis Polymer and/or the non-absorbable polymer of synthesis.In all cases, polymer composition may include such as biocompatibility Foam.Biocompatible foam may include for example porous open celled foam and/or porous closed-cell foam.Biocompatible foam Can have uniform pore morphology, or can have gradient pore form (that is, in one direction across the thickness of foam, orifice size by It is cumulative plus become macropore).In all cases, polymer composition may include porous support, porous matrix, gel-type vehicle, water Gel-type vehicle, solution matrix, thread matrix, tubulose matrix, composite interstitial substance, membrane matrix, Biostatic polymer and can biology drop One of polymer of solution or a variety of and their combination.For example, tissue thickness compensation part component may include passing through filiform The foam of matrix enhancement, or may include the foam with additional hydrogel layer, which exists in body fluid Lower stretching, extension, organizationally to further provide for compressing.In all cases, tissue thickness compensation part component can also by material and/ Or the coating in the second layer or third layer is constituted, which stretches in the presence of body fluid, organizationally to further provide for compressing. Such layer can be hydrogel, the hydrogel can for synthesis and/or natural source material, and may be, for example, biology it is durable and/ Or it is biodegradable.In some cases, it can be used the fiber that can such as provide additional flexibility, rigidity, and/or intensity non- Weaving material or fiber mesh type element enhance tissue thickness compensation part component.In all cases, tissue thickness compensates Part component has porous form, which shows gradient-structure, for example, be aperture on a surface, and another It is biggish hole on surface.Such form is even more ideal for tissue growth or hemostasis behavior.In addition, gradient can also be with change The bio-absorbable section of change is combined.Short-term absorption profile may be more suitable for realizing hemostasis；And Long-term absorption section may be implemented Better organization healing will not leak again.

The example of non-synthetic polymer includes but is not limited to lyophilized polysaccharide, glycoprotein, elastin laminin, proteoglycans, bright Glue, collagen and oxidized regenerated cellulose (ORC).The example of the absorbable polymer of synthesis is including but not limited to poly- (lactic acid) (PLA), poly (L-lactic acid) (PLLA), polycaprolactone (PCL), polyglycolic acid (PGA), poly(trimethylene carbonate) (TMC), poly- Ethylene glycol terephthalate (PET), polyhydroxy-alkanoates (PHA), glycolide and the copolymer (PGCL) of 6-caprolactone, second The copolymer of lactide and trimethylene carbonate, poly- (decanedioic acid glyceride) (PGS), polydioxanone, poly- (ortho esters), Polyanhydride, polysaccharide, poly- (ester-acid amide), tyrosine-based polyarylate, tyrosine-based polyimide carbonate, tyrosine-based polycarbonate, Poly- (D, L- lactide-carbamate), poly- (B- hydroxybutyric acid), poly- (E- caprolactone), polyethylene glycol (PEG), poly- [two (carboxylics Phenoxyl) phosphonitrile], poly- (amino acid), intend poly- (amino acid), absorbable polyurethane and their combination.In various situations Under, which may include the PLLA of about 50% to about 90% for example based on the weight of polymer composition, and The PCL of about 50% to about 10% based on the weight of polymer composition.In at least one embodiment, the polymer group Close the PLLA that object may include such as by weight about 70%, and by weight about 30% PCL.In all cases, should Polymer composition may include the PGA of about 55% to about 85% for example based on the weight of polymer composition, and by polymerization The PCL of the poidometer 15% to 45% of compositions.In at least one embodiment, which may include for example By weight about 65% PGA, and by weight about 35% PCL.In all cases, which can wrap PGA containing about 90% to about 95% for example based on the weight of polymer composition, and based on the weight of polymer composition The PLA of about 5% to about 10%.

In all cases, the absorbable polymer of synthesis may include bioabsorbable biocompatible elastomers copolymerization Object.Suitable bioabsorbable, biocompatibility elastomer copolymer includes but is not limited to 6-caprolactone and glycolide Copolymer (molar ratio of 6-caprolactone and glycolide is preferably about 30:70 to about 70:30, it is therefore preferable to 35:65 to about 65: 35, and more preferably 45:55 to 35:65)；6-caprolactone and lactide (including L- lactide, D- lactide, they Blend or lactic acid copolymer) elastomer copolymer (molar ratio of 6-caprolactone and lactide is preferably about 35:65 to about 65:35, and more preferably 45:55 to 30:70)；Dioxanone (1,4- dioxane -2- ketone) and third are handed over The elastomer copolymer of ester (including L- lactide, D- lactide and lactic acid) is (to the molar ratio of dioxanone and lactide Preferably about 40:60 to about 60:40)；6-caprolactone and to the elastomer copolymer of dioxanone (6-caprolactone with it is right The molar ratio of dioxanone is preferably about 30:70 to about 70:30)；To dioxanone and trimethylene carbonate Elastomer copolymer (30:70 is preferably from about to about 70:30 to the molar ratio of dioxanone and trimethylene carbonate)； (molar ratio of trimethylene carbonate and glycolide is preferably from about the elastomer copolymer of trimethylene carbonate and glycolide 30:70 to about 70:30)；Trimethylene carbonate and lactide are (including L- lactide, D- lactide, their blend or cream Acid copolymer) elastomer copolymer (molar ratio of trimethylene carbonate and lactide is preferably from about 30:70 to about 70: 30)；And their blend.In one embodiment, elastomer copolymer is the copolymer of glycolide and 6-caprolactone. In another embodiment, elastomer copolymer is the copolymer of lactide and 6-caprolactone.

It is published in the United States Patent (USP) 5 of entitled " the ELASTOMERIC MEDICAL DEVICE " on November nineteen ninety-five 21, 468,253 and it is published in entitled " the FOAM BUTTRESS FOR STAPLING APPARATUS " on December 4th, 2001 The disclosure of United States Patent (USP) 6,325,810 is respectively incorporated by reference accordingly to be incorporated herein.

In all cases, the absorbable polymer of synthesis can be for example including one of following substance or a variety of: can be with Product name VICRYL (polyglactic 910) from Ethicon, Inc. it is commercially available 90/10 poly- (glycolide-L- third is handed over Ester) copolymer, can with product name DEXON from American Cyanamid Co. commercially available polyglycolide, can be with commodity Title PDS is from Ethicon, Inc. commercially available polydioxanone, can be with product name MAXON from American Cyanamid Co. commercially available poly- (glycolide-trimethylene carbonate) statistic copolymer, can be with product name MONOCRYL is total from 75/25 Ethicon commercially available poly- (glycolide-E- caprolactone-poliglecaprolactone 25) Polymers.

The example of the non-absorbable polymer of synthesis includes but is not limited to polyurethane foam plastics, polypropylene (PP), poly- second Alkene (PE), polycarbonate, polyamide, such as nylon, polyvinyl chloride (PVC), polymethyl methacrylate (PMMA), polystyrene (PS), polyester, polyether-ether-ketone (PEEK), polytetrafluoroethylene (PTFE) (PTFE), polytrifluorochloroethylene (PTFCE), polyvinyl fluoride (PVF), Fluorinated ethylene propylene (FEP), polyacetals, polysulfones and their combination.The non-absorbable polymer of synthesis may include but unlimited In foam elastomer and porous elastomers, such as silicone, polyisoprene and rubber.In all cases, the synthesized polymer Object may include can be with brand name GORE-TEX Soft Tissue Patch commercially available from W.L.Gore&Associates, Inc. The expanded PTFE (ePTFE) of acquisition, and copolymerization that can be commercially available from Polyganics with brand name NASOPORE Ether-ether polyurethane foam.

The feature of the polymer composition of tissue thickness compensation part component can be for example porosity percentage, pore size, And/or hardness.In all cases, which can have such as hole of about 30% to about 99% by volume Porosity percentage.In some cases, which can have such as by volume about 60% to about 98% Porosity percentage.In all cases, which can have such as by volume about 85% to about 97% Porosity percentage.In at least one embodiment, which may include such as by weight about 70% PLLA and by weight about 30% PCL, and may include such as about 90% porosity by volume.At least one In a such embodiment, therefore, the polymer composition is by the copolymer comprising by volume about 10%.At at least one In embodiment, which may include such as by weight about 65% PGA and by weight about 35% PCL, and can have the porosity percentage of such as about 93% to about 95% by volume.In all cases, it polymerize Compositions may include the porosity for being greater than 85% by volume.Polymer composition can have such as about 5 microns to about 2000 microns of pore size.In all cases, polymer composition can have for example micro- between about 10 microns to about 100 Pore size between rice.In at least one such embodiment, which may include being total to for such as PGA and PCL Polymers.In some cases, polymer composition can have the hole for example between about 100 microns to about 1000 microns Size.In at least one such embodiment, which may include the copolymer of such as PLLA and PCL.According to In some terms, the hardness of polymer composition can be indicated with Shore hardness, which can be defined as (all with hardometer Such as sclerometer) material of measurement is to the resistance of residual indentation.In order to assess the durometer value of given material, according to entitled The ASTM program D2240- of " Standard Test Method for Rubber Property-Durometer Hardness " 00 (it, which is incorporated by reference, is incorporated herein) is pressed with hardness head pressure feet to material.Hardness head pressure feet can be pressed into material Material, is kept for the sufficiently long time (such as 15 seconds), in this case, is then read and is read by suitable scale.According to used Scale type can get reading 0 when pressure head foot complete penetration material, and when material is not pierced, can get reading 100.The reading is nondimensional.It in all cases, can be according to ASTM D2240-00, using any suitable scale such as A Class and/or OO class scale determine hardness.In all cases, the polymer composition of tissue thickness compensation part component can have Such as about 4A, to the Shore A Hardness value of about 16A, which is about 45OO to about 65OO within the scope of Shore OO. In at least one such embodiment, which may include such as PLLA/PCL copolymer or PGA/PCL copolymerization Object.In all cases, the polymer composition of tissue thickness compensation part component can have the Shore A Hardness value less than 15A.? In various situations, the polymer composition of tissue thickness compensation part component can have the Shore A Hardness value less than 10A.Various In the case of, the polymer composition of tissue thickness compensation part component can have the Shore A Hardness value less than 5A.In certain situations Under, polymer material can have the Shore OO composition value of such as about 35OO to about 75OO.

In all cases, polymer composition can have at least two in the above-mentioned characteristic identified.In various feelings Under condition, polymer composition can have at least three kinds in the above-mentioned characteristic identified.The polymer composition can have for example By volume 85% to 97% porosity, 5 microns to 2000 microns of pore size and 4A to 16A Shore A Hardness value, with And the shore OO hardness value of 45OO to 65OO.In at least one embodiment, for example, polymer composition may include by polymerization The PCL of the PLLA of the poidometer 70% of compositions and based on the weight of polymer composition 30%, and have by volume 90% porosity, the Shore A Hardness value of 100 microns to 1000 microns of pore size and 4A to 16A and 45OO to 65OO Shore OO hardness value.In at least one embodiment, for example, polymer composition may include the weight by polymer composition The PCL of the PGA of meter 65% and based on the weight of polymer composition 35%, and there is by volume 93% to 95% hole The Shore OO hardness of degree, 10 microns to 100 microns of pore size and the Shore A Hardness value of 4A to 16A and 45OO to 65OO Value.

In all cases, polymer composition may include pharmaceutically active agents.Polymer composition is releasably treated effectively The pharmaceutically active agents of amount.In all cases, when polymer composition is desorbed/absorbs, pharmaceutically active agents can be released.? In various situations, pharmaceutically active agents can be released to fluid and such as flow through above polymer composition or pass through polymer composition Blood in.The example of pharmaceutically active agents may include but be not limited to hemostat and drug, such as fibrin, fibrin ferment and oxygen Change regenerated cellulose (ORC)；Antiinflammatory medicine, such as Diclofenac, aspirin, naproxen, sulindac and hydrocortisone； Antibiotic and antimicrobial agents or antimicrobial, such as triclosan, ionic silver, ampicillin, gentamicin, more Acarasiales Plain B, chloramphenicol；And anticancer agent, such as cis-platinum, mitomycin, adriamycin.

Disclosed herein is the various methods for changing tissue thickness compensation part.Such method can be used for changing for example and tightly Any suitable layer that firmware storehouse and/or reuse surgical fasteners tool are used together.Such layer may include that any suitable work can be used What skill was formed is less than absolutely fine and close composition.For example, such technique may include such as extrusion, injection molding, weaving, freeze-drying, gas Body foaming and/or melt-blown process.There may be foams for some techniques, and other techniques may not generate foam；However, any In the case of, all it is contemplated that all such embodiments are used together with all of the embodiments disclosed herein.

In various embodiments, referring to fig. 44 to Figure 46, the end effector of reuse surgical fasteners tool such as end executes Device 100 is configured to capture, fastening and/or incision tissue.End effector 100 may include fastener cartridge 110, and Firing member 140 is also comprised, which can be advanced through fastener cartridge 110 will removedly be stored in nail bin Nail in 110 is deployed to capture in the tissue in end effector 100.In all cases, firing member 140 can be proximally The distal end of position (Figure 44) towards end effector 100 is promoted to dispose nail and transecting patient tissue simultaneously.However exist in this way Some cases, wherein may not be needed by firing member 140 towards end effector 100 distal end promote.For example, end The fastener cartridge 110 of actuator 100 can be to be can be removed and/or interchangeable, in 110 delocalization of fastener cartridge in end In the case where in actuator 100, it may not be needed to promote in end effector 100 for firing member 140.It is firing Component 140 is advanced through in the case that end effector 100 is located in end effector 100 without fastener cartridge, is hit The blade 142 of hair component 140 can cut into tissue of the capture in end effector 100 without fastening tissue simultaneously.Similarly, It has been used, or has been extended, and at least some of fastener is in advance in the fastener cartridge being located in end effector 100 In the case where fastener cartridge deployment, it may not be needed to promote in end effector 100 for firing member 140.? Firing member 140 is advanced through end effector 100 while the fastener cartridge extended in advance is located in end effector 100 In the case where, the blade 142 of firing member 140 can cut into tissue of the capture in end effector without fastening group simultaneously It knits.In various embodiments, end effector 100 may include one or more locking systems, when fastener cartridge is not present in When in end effector 100 and/or when the fastener cartridge being located in end effector 100 at least partly extends When, which can prevent firing member 140 from promoting towards distal side.Various locking systems are in entitled " SURGICAL STAPLING INSTRUMENT HAVING A SPENT CARTRIDGE LOCKOUT " and it is published on January 24th, 2006 United States Patent (USP) 6,988,649 in have it is disclosed.Entitled " SURGICAL STAPLING INSTRUMENT HAVING A The complete disclosure of the United States Patent (USP) 6,988,649 of SPENT CARTRIDGE LOCKOUT " is herein incorporated by reference.

Referring again to Figure 44 to Figure 46, fastener cartridge 110 may include warehouse and tissue thickness compensation part 120, wherein to upper Text is described further, and tissue thickness compensation part 120 can removedly be stored in warehouse against being passed through by end effector 100 The tissue implantation of interior fastener capture.Tissue thickness compensation part 120 can be positioned on above the top surface or platform of warehouse, In be removedly stored in nail 180 in the nail cavity being defined in warehouse can by such as firing member (such as sliding part 130 and/ Or firing member 140) projected from nail cavity.In certain embodiments, fastener cartridge 110 may also include driver, the driver Be configured to support nail 180 and transmit the movement of sliding part 130 to nail 180, to make nail 180 in non-firing position and It is moved between firing position.In all cases, when nail 180 is in its non-firing position, nail 180 can be at least partly embedding Enter in tissue thickness compensation part 120, and in some cases, when nail 180 is in its non-firing position, nail 180 can be by group It knits in the appropriate location that thickness compensation part 120 is maintained above storehouse platform.Will follow closely 180 be deployed in tissue before, organizing In the case that thickness compensation part 120 is relative to 180 movement of warehouse and/or nail, in some cases, tissue thickness compensation part 120 Nail 180 can be made to move relative to the movement of its optimum position or far from its optimum position.In addition, in nail 180 by before disposing, in group Knit thickness compensation part 120 from storehouse 110 remove in the case where, storehouse 110 may be not suitable for its initial expected purposes.In view of above Described, as discussed in more detail below, end effector 100 may include locking piece, which is configured to following closely 180, by before disposing, remove from warehouse or become the case where being at least partly detached from from warehouse in tissue thickness compensation part 120 Under prevent firing member 140 and/or sliding part 130 towards distal side promote to dispose nail 180.

Referring again to Figure 44 to Figure 46, tissue thickness compensation part 120 may include that (one) is configured to by 180 capture of nail Main body 121, and the locking pin 122 that (two) extend from main body 121.In all cases, when tissue thickness compensation part 120 not When removing from the suitable position above warehouse platform or substantially moving from the position, locking pin 122 may include insertion main body 121 In first end 123 and the second end 124 that is located among firing member 140 and sliding part 130.In such position In, the second end 124 of locking pin 122 can be positioned on the shoulder being limited on sliding part 130 or frame 134 and from trigger shaft 140 Among the protrusion 144 extended towards distal side.In other words, when locking pin 122 is located in sliding part 130 and trigger shaft 140 is intermediate, Locking pin 122 and sliding part 130 can cooperate so that trigger shaft 140 to be supported on to the locking shoulder 112 being defined in fastener cartridge 110 In the unlocked position of top, so that trigger shaft 140 can be promoted towards distal side and be slided when distal side percussion force is applied to trigger shaft 140 Part 130 is with percussion nail 180.When tissue thickness compensation part 120 is removed from storehouse 110 and/or substantially from relative to warehouse When required position is detached from, referring primarily to Figure 45, locking pin 122 may be no longer located in sliding part 130 and firing member 140 Between, and/or firing member 140 may not be supported in its unlocked position (Figure 44).In such cases, it fires Component 140 can become to be located in latched position, so that the distal side of firing member 140 promotes locked shoulder 112 to prevent.Extremely Under such circumstances, end effector 100 may also include for example to be configured to firing member 140 being biased into it few one kind Biasing member in lock state, such as spring.In some cases, firing member 140 can be biased into for example by biasing member It is contacted with sliding part 130, without positioning locking pin 122 therebetween, which may include the locking bit of firing member 140 It sets.

As above-described as a result, storehouse 110 is variable if tissue thickness compensation part 120 is prematurely removed from storehouse 110 It obtains inoperable.In such cases, locking pin 122 may include fuse, before firing member 140 is promoted towards distal side, in group Knit thickness compensation part 120 be removed in the case where, the fuse make storehouse 110 deactivate.In all cases, locking pin 122 may include Key, when key is located between sliding part 130 and firing member 140, which maintains in storehouse 110 in unlocked state, and Before firing member 140 is promoted towards distal side, that is, before firing member 140 starts its firing schedule, in tissue thickness compensation part 120 from storehouse 110 remove in the case where allow storehouse 110 enter lock state in.When firing member 140 is in its lock state simultaneously And when cannot promote towards distal side, the blade 142 of firing member 140 cannot cut the tissue captured in end effector 100.This Outside, in such cases, firing member 140 cannot promote sliding part 130 with percussion nail 180 towards distal side.Therefore, when tissue is thick Degree 120 no-fix of compensating part or when not being appropriately positioned on storehouse 110, tissue thickness compensation part locking piece can prevent capture from existing Tissue in end effector 100 is cut into and sutures.Before tissue thickness compensation part 120 is removed or is detached from, firing In the case that component 140 is promoted towards distal side, the firing schedule of the achievable end effector 100 of firing member 140 or its percussion row At least part of journey.In such cases, sliding part 130 is promoted towards distal side so that be limited on sliding part 130 one or Multiple slopes 132 can promote nail 180, and the blade 142 of firing member 140 can cut into tissue thickness compensation part 120 and/or catch Obtain the tissue in end effector 100.In some cases, firing member 140 can contact locking pin 122 and in percussion structure Part 140 is displaced from it when promoting towards distal side.In such cases, locking pin 122 can be flexible.In all cases, Locking pin 122 can be made of for example bioabsorbable material and/or biocompatible materials.In some cases, structure is fired Part 140 can cut locking pin 122 when firing member 140 is promoted towards distal side.Under any circumstance, once firing member 140 It at least partly promotes, the purpose of locking pin 122 may become out-of-date.In other words, tissue thickness compensation part locking piece is available Make initial inspection and be present in end effector with verifying tissue thickness compensation part, and initial inspection once is completed, Carry out the firing schedule of end effector.

Referring again to Figure 47 to Figure 50, end effector 200 may include anvil block 260, and also comprise fastener cartridge 210, which includes warehouse 214 and tissue thickness compensation part 220, wherein further described above, tissue is thick Degree compensating part 220 can be against the tissue by end effector 200 by the fastener capture being removedly stored in warehouse 214 Implantation.Tissue thickness compensation part 220 can be positioned on above the top surface or platform 211 of warehouse 214, wherein removedly storing Nail in the nail cavity being defined in warehouse 214 can be by such as firing member (such as sliding part 230 and/or firing member 240) It is projected from nail cavity.In certain embodiments, fastener cartridge 210 may also include driver, which is configured to prop up Nail and the movement of sliding part 230 to nail is transmitted, to move nail between non-firing position and firing position.Various In the case of, when nail is in its non-firing position, nail can be at least partially embedded in tissue thickness compensation part 220, and at certain In a little situations, when nail is in its non-firing position, during tissue thickness compensation part 220 can be held in place by nail.? Before nail is deployed in tissue, in the case where tissue thickness compensation part 220 is relative to warehouse 214 and/or nail movement, one In a little situations, tissue thickness compensation part 220 can be such that nail moves relative to the movement of its optimum position or far from its optimum position.This Outside, in nail by before disposing, in the case where tissue thickness compensation part 220 is removed from storehouse 210, storehouse 210 may be not suitable for Its initial expected purposes.In view of the above, as discussed in more detail below, end effector 200 may include locking piece, the lock Determine part to be configured to be removed or become at least from warehouse 214 in tissue thickness compensation part 220 by before disposing in nail Prevent firing member 240 and/or sliding part 230 from promoted towards distal side to dispose nail in the case where being partly detached from from warehouse.

Referring again to Figure 44 to Figure 46, tissue thickness compensation part 220 may include that (one) is configured to by nail capture Main body 221, and ring or tie-down 222 that (two) extend from main body 221.In all cases, referring primarily to Figure 47, ring 222 May include the end being at least partially embedded in main body 221 and extend between the ends can be with sliding part 230 releasedly The middle section of engagement.In some cases, ring 222 may include such as suture or flexible wires.In some cases, ring 222 It can be made of for example bioabsorbable material and/or biocompatible materials.Referring primarily to Figure 48, sliding part 230 may include Longitudinal main part 236, the hook 238 extended from main part 236, and be limited to narrow between main part 236 and hook 238 Slot 237.As shown in figure 48, when tissue thickness compensation part 220 is located in 211 top of storehouse platform, ring 222 is located in slit 237 It is interior, and sliding part 230 and firing member 240 are in non-firing position.In addition as shown in figure 48, prolong from firing member 240 The distal side protrusion 244 stretched is against the positioning of support shoulder 234 being limited on sliding part 230 and/or is positioned on, the branch Firing member 240 is maintained in unlocked position by brace shoulder portion, that is, is held in this position, in this position, when percussion is transported The dynamic locking shoulder that when being applied to firing member 240, the distal movement of firing member 240 will be limited in end effector 200 Portion 212 hinders or at least substantially hinders.Therefore, when firing member 240 is kept in its unlocked position by sliding part 230, Referring to fig. 49, firing member 240 will slide past locking shoulder 212 to promote sliding part 230 towards distal side, and percussion is removedly The nail being stored in warehouse 214, and cut tissue thickness compensation part with blade 242 and be located in end effector 200 Tissue.As shown in figure 49, when sliding part 230 towards distal side promote when, ring 222 slidably exit be defined in it is narrow in sliding part 230 Slot 237.

Suitable position above platform 211 of the tissue thickness compensation part 220 from the removal of storehouse 210 or substantially from storehouse 210 In the case where movement, referring now to Figure 50, tissue thickness compensation part 220 can pull sliding part 230 towards distal side, so that percussion structure Part 240 is no longer supported by sliding part 230.More specifically, the ring 222 of tissue thickness compensation part 220 being located in slit 237 can Sliding part 230 is pulled from its non-firing position towards distal side, so that support shoulder 234 is no longer located in the remote of firing member 240 Below lateral process 244.In such cases, firing member 240 can be shifted down into latched position, wherein firing member 240 Distal movement can be locked shoulder 212 obstruction.In some cases, may also include can be by firing member for end effector 200 240 are biased into the biasing member in its lock state, such as spring.When firing member 240 is in its lock state, percussion Component 240 cannot be moved toward the far side to promote sliding part 230, and nail is fired from warehouse 210, and/or incision capture is being held Tissue in portion's actuator 200.Although sliding part 230 can be pushed away towards distal side when tissue thickness compensation part 220 is removed from storehouse 210 Into, but in all cases, sliding part 230 may not be sufficiently advanced to dispose and follow closely from storehouse 210.When the use of surgical instruments When person recognizes that firing member 240 is in the lock state middle, user can by nail bin 210 from end effector 200 remove and It is replaced with such as nail bin 210, wherein tissue thickness compensation part 220 is properly positioned at 211 top of platform and sliding part 230 Not yet promoted from its non-firing position towards distal side.It is contemplated that other embodiments, wherein nail bin can not be from end effector It removes, in such embodiment, is removed in tissue thickness compensation part from nail bin and/or firing member enters lock state In in the case where, end effector can be completely replaced.

Turning now to Figure 51 to Figure 53, nail bin 310 may include warehouse 314 and the sliding that is movably positioned in warehouse 314 Part 330.Similar to above, warehouse 314 may include for example multiple securing member chambers, such as securing member chamber 316, and, for example, be limited to Longitudinal slit therein, such as cutter slit 318.Sliding part 330 may include the center master being slidably located in cutter slit 318 Body portion 336 and the hook 338 extended from center body portion 336.Referring primarily to Figure 51, the tissue thickness compensation part in storehouse 310 320 may include main part 321 and the fastener 322 from the extension of main part 321, wherein not hitting when sliding part 330 is in it When sending out or not promoting in position, fastener 322, which can be releasably held in, to be defined between hook 338 and center body portion 336 Slit 337 in.Similar to above, fastener 322 may include the end 323 being mounted in main body 321 and can be from tissue thickness The main body 321 of compensating part 320 extends proximally, wherein the case where such as tissue thickness compensation part 320 is removed from warehouse 314 Under, fastener 322 can pull sliding part 330 towards distal side, so that the support shoulder 334 being limited in center body portion 336 is not It can support on it again firing member (such as firing member 240), and make firing member that can enter lock state.Each In the case of kind, the user of surgical instruments can attempt to re-assembly or be repositioned at warehouse 314 for tissue thickness compensation part 320 The top of platform 311；However, the repositioning due to tissue thickness compensation part 320 will not reset sliding part 330, so hitting Hair component 340 will remain in lock state.Therefore, such arrangement can prevent the quilt in the case where it has been tampered of storehouse 310 It uses.

In all cases, referring again to Figure 51 to Figure 53, from sliding part 330 and/or the central part 336 of slit 337 At least part of the hook 338 of the restriction of extension therebetween may extend into 311 top of platform.In some cases, from sliding part 330 and/or at least part for limiting hook 338 therebetween for extending of central part 336 of slit 337 may extend into cutter slit 318 tops.In such embodiment, when tissue thickness compensation part 320 is assembled into warehouse 314, fastener 322 can be easy to slide It moves in slit 337.In some cases, fastener 322 can be positioned on 311 top of platform surface or fixed against it of warehouse 314 Position.In all cases, referring primarily to Figure 53, warehouse 314 may include recessed portion or pit 319 defined therein, work as sliding When part 330 is in it and does not fire or do not promote in position, hook 338 be can be positioned in the recessed portion or pit.In such reality It applies in scheme, the top of hook 338 can be positioned in 311 lower section of platform surface.In all cases, pit 319 may also include limit The one or more inclined surfaces 313 being scheduled in the distal end of pit 319, and extended downwardly from platform surface 311.One In a little situations, when sliding part 330 is promoted towards distal side, fastener 322 can abut inclined surface 313, in such cases, hook 338 Then it can be separated with fastener 322.In all cases, recessed portion 319 is configured to be conducive to compensate in tissue thickness Fastener 322 is assembled into sliding part 330 when part 320 is assembled into warehouse 314.In various embodiments, slit 337 can be longitudinal Ground extends and may include the distal end and open proximal end of closure, and wherein fastener 322 can be from open proximal end It slides into slit 337.In the case where tissue thickness compensation part 320 is not prematurely removed or is detached from from storehouse 314, sliding part 330 can promote towards distal side, so that fastener 322 passes through its distal end and leaves slit 337 and to be limited on sliding part 330 Slope 332 nail can be projected from nail bin 310.

In all cases, at least one adhesive can be used that tissue thickness compensation part is adhered to sliding part.Such In the case of, the adhesive attachment between tissue thickness compensation part and sliding part can be sufficiently strong to allow tissue thickness compensation part in group It knits and pulls sliding part towards distal side in the case that thickness compensation part is removed from storehouse.Make when sliding part is promoted by firing member towards distal side For firing schedule a part when, between tissue thickness compensation part and sliding part adhesive attachment may fail, to allow Sliding part is slided relative to tissue thickness compensation part towards distal side.In all cases, thermal welding can be used in tissue thickness compensation part Technique and/or heat forming technology are integrated to sliding part.In such cases, the combination between tissue thickness compensation part and sliding part It can be sufficiently strong to allow tissue thickness compensation part to lead sliding part towards distal side in the case where tissue thickness compensation part is removed from storehouse It draws.When sliding part promotes a part as firing schedule towards distal side by firing member, tissue thickness compensation part and sliding part Between combination may fail, thus allow sliding part relative to tissue thickness compensation part towards distal side slide.

In some cases, for example, ring, fastener and/or label can be integrally formed with tissue thickness compensation part.In various feelings Under condition, for example, ring, fastener and/or label may include the material with tissue thickness compensation part one.In some cases, it can incite somebody to action Additional layer is attached to tissue thickness compensation part.In all cases, this layer may include the installation section engaged with sliding part.

Turning now to Figure 54, it is similar to above, sliding part 430 may include center body portion 436, and also comprise more A slope 432, the slope are configured to for example will removedly be stored in the intracorporal nail injection in storehouse.It is also similarly to Text, main part 436 may include hook 438 extending therefrom, wherein slit 437 can be limited to main part 436 and hook 438 it Between.In some cases, slit 437 may include the distal end 437a and open proximal end 437d of closure.In various feelings Under condition, slit 437 may also include the first part 437b extended in a first direction and the second part extended in a second direction 437c.In some cases, first part 437b can be extended along a longitudinal axis and second part 437 can be transverse to longitudinal axis The second axis of line extends.In at least one such situation, second part 437c can be angled relative to first part 437b Extend.

Turning now to Figure 55 to Figure 58, sliding part 530 may include first part 535, and also comprise second Divide 536, which can be relative to first part 535 in unlocked position (Figure 55 and Figure 57) and latched position (Figure 56 and figure 58) it is moved between.First part 535 may include that (one) is configured to (such as be limited in nail bin 510 in longitudinal slit Cutter slit 518) in the central part that slides, and (two) be configured to penetrate the nail being removedly stored in storehouse 510 Multiple slopes 532 out.The central part of first part 535 may include the first slit 533a and the second slit defined therein 533b.First slit 533a and the second slit 533b is configured to receive the pin extended from second part 536 respectively 531a and 531b.First pin 531a is configured to slide in the first slit 533a, and the second pin 531b can be by structure It causes to slide in the second slit 533b, to allow second part 536 to rotate relative to first part 535.Various In the case of, the first pin 531a can be closely received in the first slit 533a, so that the first slit 533a can constrain the first pin 531a is along the movement of first path, and similarly, the second pin 531b can be closely received in the second slit 533b, so that the Two slit 533b can constrain the second pin 531b along the movement in the second path.Referring primarily to Figure 57, second of sliding part 530 Dividing 536 may include the arm for being configured to slide in cutter slit 518, and wherein arm may include being limited in its proximal end Support shoulder 534 and the hook 538 being limited in its distal end.Similar to above, support shoulder 534 is configured to It is in the non-firing position of nearside in sliding part 530 and tissue thickness compensation part 220 is for example in the platform surface in storehouse 510 Firing member 240 is supported in such as unlocked position when above 511 or against its positioning.It is also similarly to above, hook 538 can It is configured to releasably hold the ring 222 of tissue thickness compensation part 220, so that in tissue thickness compensation part 220 from storehouse In the case that body removes and/or be substantially opposite warehouse displacement, ring 222 can be pulled on second part 536 with by the Two parts 536 are pivoted in its latched position, as shown in figure 58.In such latched position of second part 536, shoulder is supported 534 can no longer support the distal side protrusion 244 of firing member 240, and firing member 240 can drop downward into its latched position. As shown in figure 58, second part 536 to the rotation in its latched position can make support shoulder 534 move toward the far side and/or Down away from firing member 240.Same as shown in figure 50, firing member 240 may include the lock extended from its opposite side 541, which is configured to the adjacent locking shoulder 212 when firing member 240 is in its latched position.When percussion structure When part 240 is kept in its unlocked position by sliding part 530, lock 541 can not contact locking shoulder 212 and firing member 240 can be advanced through storehouse 510.

In all cases, as described above, a part of nail drive slider may extend into above the platform surface of warehouse. For example, referring again to Figure 52 and Figure 54, such as the hook 338 of sliding part 330 (Figure 52) and/or the hook 438 of sliding part 430 may extend away Above to platform surface.In such cases, hook 338 and/or hook 438 can be just translated to the far side on the mesa surface, and Under some cases, the tissue thickness compensation part that platform surface is positioned or is located in above platform surface is contacted against.In certain feelings Under condition, tissue thickness compensation part can be lifted up far from warehouse and be conducive to mend tissue thickness by hook 338 and/or hook 438 It repays part and is gradually discharged from storehouse.For example, hook 338 and/or hook 438 can begin at the proximal end of tissue thickness compensation part and towards groups The distal end movement for knitting thickness compensation part, initially to promote the proximal end of tissue thickness compensation part, and then by it It is gradually promoted far from storehouse platform until the distal end of tissue thickness compensation part is finally promoted far from warehouse.In other cases, As follows further to discuss in more detail, the part for the contact tissue thickness compensation parts of sliding part is it may be preferred that downwards It deflects and/or does not otherwise interfere tissue thickness compensation part when sliding part is promoted towards distal side.

Turning now to Figure 59 and Figure 60, nail bin 610 may include warehouse 614, the tissue thickness for releasably holding warehouse 614 Compensating part 620 is spent, and is configured to longitudinal direction and traverses warehouse 614 and project the nail being removedly stored in warehouse Sliding part 630.Sliding part 630 may include with main body portion 635, the branch brace shoulder for limiting multiple ramped surfaces on it Portion 634, and the arm 636 extended from main part 635.In all cases, arm 636 can be assembled into main body portion 635.For example, arm 636 may include for example being embedded in the first end in main body portion 635 and the second end including hook 638 Portion.In all cases, arm 636 may include the cantilever beam extended from main body portion 635.In some cases, arm 636 can It is made of such as elasticity and/or material flexible.Similar to above, slit 637 can be limited between hook 638 and arm 636, can It is configured to releasably hold tissue thickness compensation part 620 when sliding part 630 is in the non-firing position of its nearside A part.For example, tissue thickness compensation part 620 can incite somebody to action in the case where tissue thickness compensation part 620 is pulled away from warehouse 614 Sliding part 630 is pulled towards distal side far from firing member, so that firing member enters in lock state.

In all cases, further described above, at least part (such as hook 638) of arm 636 is extensible To 611 top of platform surface of warehouse 614.In some cases, when sliding part 630 is in its proximal position (Figure 59), Arm 636 can with for example from tissue thickness compensation part 620 extend engagement of loops, and sliding part 630 towards distal side promote when, arm 636 can be disengaged with ring.When sliding part 630 is promoted towards distal side, in some cases, arm 636 can contact tissue thickness's benefit It repays the main part 621 of part 620 and bends downwards.In all cases, when sliding part 630 is promoted towards distal side, deflection Arm 636 can slide in the longitudinal knife slot 618 being defined in warehouse 614.In some cases, referring to Figure 60, longitudinal slit 618 distal end can be limited by nose wall or roof 619, wherein when sliding part 630 reaches the distal end 617 in storehouse 610, arm 636 can be in 619 slip underneath of nose wall, so that the firing schedule of end effector is achievable.In some cases, arm 636 may It does not deflect down or deflects substantially downward by tissue thickness compensation part 620, wherein when arm 636 reaches longitudinal slit 618 When end, arm 636 be can contact nose wall 618 and bend downwards so as in its lower slider, as shown in figure 60.In all cases, As a result, flexible arm 636 allows, firing schedule is completed and sliding part 630 is parked at the distal end in storehouse.

Turning now to Figure 61, sliding part such as sliding part 730 for example may include main body portion 735 and moveable arm 736.Similar to above, main body portion 735 may include one or more nail driving slopes 732 and be configured to by Firing member is supported on the support shoulder 734 in unlocked position, as described above.Arm 736 may include first end and the second end, The first end is pivotable and/or is rotatably mounted to main body portion 735, which includes being configured to The hook 738 being releasably engaged with tissue thickness compensation part, as described above.When sliding part 730 is promoted towards distal side, hook 738 can separate from tissue thickness compensation part；However, the upper face of hook 738 can keep the bottom table with tissue thickness compensation part Face contact.In such cases, arm 736 can be for example pivoted downwardly in cutter slit 318, so as to below tissue thickness compensation part Sliding.More specifically, arm 736 can be pivoted to the position of reduction or recess from the uppermost position (Figure 61) of raising or protrusion.? In various situations, sliding part 730 may also include the bullet for being for example configured to be biased into arm 736 in its raised position Property biasing member, such as spring 731.When arm 736, which has been rotated downwardly to it, to be reduced in position, spring 731 can apply to arm 736 Biasing force, the arm are passed in tissue thickness compensation part.In some cases, spring 731 can be positioned in arm 736 and limit Among the frame part 733 on main body portion 735.In all cases, spring 731 may include for example prolonging from arm 736 The cantilever spring or leaf spring stretched.When arm 736 pushes down on, cantilever spring is configured to along such as frame part 731 Flexure and/or sliding.In various embodiments, main body portion 735 may also include such as stop shoulder 739, the stop Shoulder can limit the upward rotation or traveling of arm 736.Under any circumstance, it is similar to above, arm 736 is configured to It contacts roof 619 and is rotated down when firing schedule being allowed to complete.

In all cases, nail may include base portion and one or more legs from base portion extension.In some cases, it follows closely It may include the base portion with first end and the second end, from the first leg of first end extension, and extend from the second end The second leg.In some cases, nail can be by including that the continuous lines of the first leg, base portion and the second leg are formed.The first of continuous lines End may include the tip of the first nail leg, and the second end of continuous lines may include the tip of the second nail leg.One such nail, I.e. nail 800 is shown in such as Figure 62.Nail 800 may include base portion 802, from the first end of base portion 802 extend the first nail leg 804, and the second nail leg 804 extended from the second end of base portion 802.First nail leg 804 may include the first tip 806, and And similarly, the second nail leg 804 may include the second tip 806.In all cases, tip 806 is configured to penetrate Tissue, the tissue T being such as shown in such as Figure 62.In some cases, tip 806 can be to be sharp, and can be for example, by Mould pressing process is formed.In various embodiments, line can be made of such as titanium and/or stainless steel.

In various embodiments, nail 800 for example at which in its unshaped configuration when can be U-shape or at least base U-shape in sheet.In such embodiment, the leg 804 for following closely 800 can be parallel to each other or at least substantially parallel to each other.This Outside, in such embodiment, leg 804 can perpendicular to or be at least substantially orthogonal to base portion 802.In certain embodiments In, nail 800 for example at which in its unshaped configuration when can for V-arrangement shape or at least substantially V-arrangement shape.In such reality It applies in scheme, it is not parallel to each other for following closely 800 leg 804；On the contrary, leg 804 can extend along non-flat line direction.In addition, such In embodiment, one or two of leg 804 is not orthogonal to base portion 802, and wherein one or two of leg 804 can be along inclination Extend in the direction of base portion 802.In all cases, leg 804 can extend outwardly or open relative to the center of nail or middle line.? In any case, nail 800 can be removedly stored in nail bin, be projected to pierce tissue, as shown in Figure 62, then from nail bin Contact is located in the anvil block on opposite sides of tissue.Anvil block is configured to that nail 800 is made to be deformed into any suitable shape, Such as B form configuration, for example, it is same as shown in Figure 62.The nail configuration of various formings such as B form configuration can limit tissue retention Region, such as tissue retention area 807, which is configured to organize to be trapped in nail.

As described above, nail can removedly be stored in be defined in it is intracavitary in warehouse.Warehouse 810 is shown in Figure 63, It may include being defined in one or more of nail cavities 812.Referring to Figure 63, Figure 68 and Figure 69, each nail cavity 812 may include first End 814 and the second end 814.In embodiment of certain embodiments such as including longitudinal end actuator, for example, the One end 814 may include the proximal end of nail cavity 812 and the second end 814 may include the distal end of nail cavity 812.Various In the case of, nail can be positioned in nail cavity 812, so that the first leg 804 of nail 800 is located in the first end 814 of nail cavity 812, And the second leg 804 is located in the second end 814.In all cases, nail cavity width can be limited to the end of nail cavity 812 Between 814.The base portion 802 of nail can be limited by base widths, which is equal or shorter than such as nail cavity width.In certain feelings Under condition, nail can have the nail width between the tip 806 that can be limited to nail leg 804.In some embodiments, nail width can wait In nail cavity width.In various embodiments, nail width can be wider than nail cavity width.In such embodiment, leg 804 can be with nail The end 814 of chamber 812 contacts and can be when nail is located in nail cavity 812 by the inside fexible bias pressure in end 814.It is upward when following closely When being lifted out nail cavity 812, leg 804 can flexibly be unfolded outward when it occurs from nail cavity 812.For example, nail can be positioned on nail cavity In 812 so that when nail in its do not fire or non-raised position in when, the tip 806 of nail leg 804 does not extend to warehouse 810 Above top surface or platform.In such position, tip 806 can be positioned so as to be flushed or recessed with the platform 811 of warehouse 810 It falls into below the platform.Alternatively, the tip 806 of leg 804 can extend at least partly into 811 top of platform of warehouse 810.? In any case, when nail is lifted up, nail tip end 806 may alternatively appear in 811 top of platform and occur in leg 804 from chamber 812 When be unfolded outward.During the promotion of nail sometimes, leg 804 may be contacted no longer with the end 814 of nail cavity 812, and Leg 804 can be no longer by the side wall inward bias of nail cavity 812.

In all cases, anvil block may include one or more pits, which is configured to following closely 800 from nail bin The tip 806 of nail leg 804 is received when injection.Anvil block pit is configured to for example inwardly overturn nail leg 804 towards each other Or bending.In other cases, anvil block pit be configured to for example by nail leg 804 be outwardly away from each other overturning or it is curved It is bent.However, in some cases, one or more of nail leg of nail can miss nail pit and possibly can not suitably become Shape.In some cases, the one or more in nail leg may not contact anvil block and may be at all indeformable.In any feelings Under condition, tissue suitably may not be captured and/or be maintained at it and organize in retention area by nail.In addition, deformity or unshaped Nail may not to tissue apply needed for compression pressure.In some cases, lopsided or unfashioned nail may not be protected It holds in the tissue and can become and organize to be detached from.

Referring again to Figure 62, nail 800 and/or various other nails disclosed herein may include one extending therefrom or more A barb.In all cases, barb is configured to tissue of the engagement capture in nail and/or around nail.Certain In the case of, barb can help to that holding will be followed closely within the organization, especially when nail has become deformity or unshaped.Following closely 800 may include The barb extended from one or two of leg 804.For example, each leg 804 may include one faced out from the center of nail 800 Or multiple barbs 808 and/or the inward-facing one or more barbs 809 in center towards such as nail 800.In certain situations Under, barb 808 can extend away from tissue retention area 807 and/or barb 809 can extend towards tissue retention area 807 or It extends in tissue retention area.As shown in Figure 62, following closely two in 800 nail leg 804 may include barb 808 and barb 809. In some cases, nail leg 804 may include barb 808, but not include barb 809.Nail 820 is shown in Figure 63 comprising barb 808, but do not include barb 809.In some cases, nail leg 804 may include barb 809, but not include barb 808.Nail 830, 840,850,860 and 870 are shown in Figure 64, Figure 65, Figure 66, Figure 67 and Figure 68 comprising barb 809, but do not include down Hook 808.In some embodiments, for example, the first leg 804 of nail may include barb 808, and the second leg 804 followed closely may include Barb 809.

In all cases, when nail is in unshaped configuration, the leg 804 and base portion 802 of nail can limit nail plane.? Hook 808 can extend outwardly from the leg 804 in such nail plane.Similarly, barb 809 can be inside from the leg 804 in such plane Extend.In some cases, nail may include the barb being laterally extended relative to such nail plane.It is contemplated that other embodiment party Case, wherein leg 804 and base portion 802 are not located at or are fully located in single plane.In such embodiment, barb can be along any Suitable direction extends.In various embodiments, referring now to Figure 67, nail such as nail 860 for example may include prolonging from base portion 802 The barb 803 stretched.In all cases, barb 803 can extend inward towards the tissue retention area 807 of nail 860.In certain situations Under, barb 803 can be outwardly away from the extension of tissue retention area 807.As shown in Figure 67, barb 803 can be by leg 804 and base portion Extend in the 802 nail planes limited.In some cases, barb 803 can be laterally extended relative to such nail plane.Various examples Property barb configuration is hereinafter discussed in further detail.

In all cases, nail leg 804 may include the array of the barb 808 extended along its whole length.In some cases Under, nail leg 804 may include along the array for being less than the barb 808 that its whole length extends.By way of example, referring to Figure 62, nail 800 leg 804 respectively includes the array of the barb 808 extended along the whole length for being less than leg 804.Similarly, referring to Figure 63, nail 820 leg 804 respectively includes the array of the barb 808 extended along the whole length for being less than leg 804.Referring to nail 800, for example, falling The array of hook 808 can extend along each of leg 804 from the base portion 802 of nail 800 towards the tip of leg 804 806.As shown in Figure 62, The array of barb 808 may not extend to the tip 806 of leg 804.In all cases, the array of barb 808 can be along such as leg The half of 804 length or approximately half of extension；However, any suitable length of barb array can be used.For example, barb 808 array can extend along the length half for being less than leg 804 or greater than the half of its length.In some embodiments, barb 808 array can extend along each of leg 804 from the tip of leg 804 806 towards base portion 802.In such embodiment, barb 808 array may not extend to base portion 802.In some embodiments, leg 804 may include the array of barb 808, not prolong Reach tip 806 or the base portion 802 of leg 804.In certain embodiments, leg 804 may include the more than one battle array of barb 808 Column.

In all cases, further described above, nail leg 804 may include the barb extended along its whole length 809 array.By way of example, referring to Figure 64, the leg 804 for following closely 830 respectively includes falling of extending of whole length along leg 804 The array of hook 809.In some cases, nail leg 804 may include along the array for being less than the barb 809 that its whole length extends.With Example way, referring to Figure 65, the leg 804 for following closely 840 respectively includes the barb 809 extended along the whole length for being less than leg 804 Array.Similarly, referring to Figure 68, the leg 804 for following closely 870 respectively includes the barb 809 extended along the whole length for being less than leg 804 Array.Referring to nail 840, for example, the array of barb 809 can along each of leg 804 from nail 840 base portion 802 towards leg 804 point End 806 extends.As shown in Figure 65, the array of barb 809 may not extend to the tip 806 of leg 804.In all cases, The array of hook 809 can be along such as half of the length of leg 804 or approximately half of extension；However, any of barb array can be used Suitable length.For example, the array of barb 809 can extend along the length half for being less than leg 804 or greater than the half of its length.? In some embodiments, the array of barb 809 can extend along each of leg 804 from the tip of leg 804 806 towards base portion 802.? In such embodiment, the array of barb 809 may not extend to base portion 802.In some embodiments, as shown in Figure 66, Leg 804 may include the array of barb 809, not extend to tip 806 or the base portion 802 of leg 804.In certain embodiments, Leg 804 may include the more than one array of barb 809.

Various barb configurations are shown in Figure 70 into Figure 73, but any suitable barb configuration can be used.Referring to Figure 70, nail Leg 804 may include a for example, at least barb 809.In all cases, barb 809 may include pin.Pin may include can be from The first surface 809a and second surface 809b that the periphery 805 of nail leg 804 extends.First surface 809a may include such as nauropemeter Face, convex surface and/or concave surface.Second surface 809b may include for example flat or at least substantially flat surface. In all cases, first surface 809a and second surface 809b can be focused at such as edge 809c.Barb 809, which can be used, appoints What suitable technique is formed.For example, Sheet Metal Forming Technology can be used to be formed for barb 809.In at least one embodiment, shaping dies Such as can be used for impacting include leg 804 line periphery 805, form barb 809 to upset or interfere enough materials.? In various situations, barb may include for example any suitable tip or burr.In various embodiments, barb 809 can be cone Shape.In all cases, barb 809 may include the base portion adjacent with periphery 805, and the base portion is thicker than the tip of barb 809.

Referring now to Figure 68, Figure 69, Figure 71 and Figure 71 A, nail leg 804 may include a for example, at least barb 879.At least In one embodiment, barb 879 can extend around a part on the periphery 805 of nail leg 804.In all cases, barb 879 It may include the first surface 879a and second surface 879b that can extend from the periphery of nail leg 804 805.First surface 879a may include Such as inclined surface, convex surface and/or concave surface.Second surface 879b may include for example flat or at least substantially put down Smooth surface.In all cases, first surface 879a and second surface 879b can be focused at such as edge 879c.Various In the case of, edge 879c can be for example bowed.Any suitable technique can be used to be formed for barb 879.For example, barb 879 can It is formed using Sheet Metal Forming Technology.In at least one embodiment, shaping dies for example can be used for impacting the week of the line including leg 804 Side 805 forms barb 879 to upset or interfere enough materials.Referring primarily to Figure 71 A, the line including leg 804 can be by straight Diameter 801 limits, and barb 879 can be limited by the big diameter of diameter group 801.Correspondingly, the line including leg 804 can be limited by radius It is fixed, and barb 879 can be limited by the radius bigger than line radius.In various embodiments, barb 879 can be taper.? In various situations, barb 879 may include the base portion adjacent with periphery 805, and the base portion is thicker than the tip of barb 879.

Referring now to Figure 72, nail leg 804 may include a for example, at least barb 889.In at least one embodiment, Hook 889 can extend around the entire periphery 805 of nail leg 804.In all cases, barb 889 may include can be from the week of nail leg 804 The first surface 889a and second surface 889b that side 805 extends.First surface 889a may include such as inclined surface, convex surface And/or concave surface.Second surface 889b may include for example flat or at least substantially flat surface.In various situations Under, first surface 889a and second surface 889b can be focused at such as edge 889c.In all cases, edge 889c can be Such as it is bowed.Any suitable technique can be used to be formed for barb 889.For example, Sheet Metal Forming Technology can be used to be formed for barb 889.? In at least one embodiment, shaping dies for example can be used for impacting the periphery 805 of the line including leg 804, to upset or to do Enough materials are disturbed to form barb 889.Line including leg 804 can be limited by linear diameter, and barb 889 can be by than linear diameter Big diameter limits.Correspondingly, the line including leg 804 can be limited by radius, and barb 889 can be by the radius bigger than line radius It limits.In various embodiments, barb 889 can be taper.In all cases, barb 889 may include and 805 phase of periphery Adjacent base portion, the base portion are thicker than the tip of barb 889.

Referring now to Figure 73, nail leg 804 may include a for example, at least barb 899.In all cases, barb 899 can Including pin.Pin may include the first surface 899a and second surface 899b that can extend from the periphery of nail leg 804.First surface 899a may include such as inclined surface, convex surface and/or concave surface.Second surface 899b may include for example flat or extremely Few substantially flat surface.In all cases, first surface 899a and second surface 899b can be focused at such as edge At 899c.Any suitable technique can be used to be formed for barb 899.For example, Sheet Metal Forming Technology can be used to be formed for barb 899.At least In one embodiment, shaping dies for example can be used for impacting the periphery of the line including leg 804, enough to upset or to interfere Material forms barb 899.In various embodiments, the line including nail may include one or more flattened sides.At least In one embodiment, line may include for example opposite flattened side 895.In at least one such embodiment, planar side Face 895 is formed as cylindrical wires.In some cases, other than flattened side 895, line can keep one or more cylinders Shape surface.In all cases, barb may include for example any suitable tip or burr.In various embodiments, barb 899 can be taper.In all cases, barb 899 may include the base portion adjacent with the periphery of leg 804, which compares barb 899 tip is thick.

In all cases, the leg of nail can limit nail plane.The base portion of nail may or may not be located in nail plane.? Under any case, the one or more barbs extended from leg and/or base portion can extend in nail plane and/or relative to Nail plane extends parallel to.In some cases, the one or more barbs extended from leg and/or base portion can be outside from nail plane Extend.The one or more barbs extended from leg and/or base portion can be extended transversely with relative to nail plane.In all cases, Barb can be extended circumferentially over upon around nail leg.Such barb can extend in nail plane and extend outwardly from nail plane.Some In the case of, barb can extend around the entire perimeter of nail leg.In some cases, barb can extend less than 360 degree around nail leg. The barb extended in nail plane can readily control the tissue in nail plane.It can readily control from the nail outwardly extending barb of plane Follow closely the tissue except plane.Nail and/or nail leg may include one or more barbs for extending and from nail plane in nail plane Outwardly extending one or more barb.

Referring again to Figure 62, the barb extended from nail leg 804 is configured to keep nail leg 804 within the organization. As described above, in some cases, nail leg 804 can be by anvil block at deformity and/or unshaped, and due to extending therefrom one A or multiple barbs, nail leg 804 can still maintain within the organization.In all cases, barb is configured to organize It is trapped in the tissue retention area of nail.In some cases, barb is configured to keep tissue against base portion 802. In such cases, barb can apply compressing force or pressure to tissue.As above embodiment institute shown in Figure 70 to Figure 73 is combined It states, barb may include such as inclination, convex and/or concave top surface, such as surface 809a, 879a, 889a and/or 899a. The top surface of barb is configured to be conducive to be inserted into tissue and/or be inserted through tissue for nail leg 804 and barb. Equally as above described in the embodiment in conjunction with shown in Figure 70 to Figure 73, barb may include for example flat or at least substantially flat Bottom surface, such as surface 809b, 879b, 889b and/or 899b.The bottom surface of barb is configured to inhibit to fall Hook and nail leg 804 are removed from tissue.As above-mentioned as a result, in some cases, the top surface of barb is configured to Tissue is enough pierced through, and the bottom surface of barb is configured to subjacent tissue.In all cases, the tip of nail leg 804 806 are configured to puncturing hole in the tissue, and nail leg extending therefrom 804 and barb are configured to flexibly Deployment aperture, so that tissue can flow around barb when nail leg 804 is pushed through tissue and flow back into the bottom of barb Lower face.

In certain embodiments, the first barb can extend from the first leg 804 of nail, and the second barb can be from the of nail Two legs 804 extend.In all cases, the first barb and the second barb can be identical between base portion 802 or at least substantially Identical distance.In some cases, the first barb and the second barb can be identical away from base portion 802 or at least substantially identical perpendicular Straight Distance positioning.As described above, nail leg 804 may include the array of the barb extended along the length of nail leg 804.In various embodiment party In case, referring primarily to Figure 62, nail may include first leg 804 with the first array of barb and the second array with barb The second leg 804, wherein the first array of barb and the second array of barb are configured to collaboratively be maintained at nail In tissue.In various embodiments, the barb from the first array and the barb from second array may include being configured to It can be away from a pair of of the barb for engaging tissue at such as identical vertical distance of base portion 802.In all cases, nail may include being more than A pair of of barb.In some cases, each pair of of barb centering can enough be caused the engagement group at away from the different vertical distances of base portion 802 It knits.In such cases, nail can be suitble to the use of different tissues thickness.For example, a pair is fallen when nail is for suturing thin tissue Hook or less than all barbs to engageable thin tissue.If nail for suturing thick tissue, however, additional barb pair or All barbs are to engageable tissue.It in certain embodiments, can be according to tissue thickness or group from the barb that leg 804 extends The mode for knitting the range of thickness arranges that the tissue thickness is closed by stapling.For example, barb 808 and 809 can referring again to Figure 62 Selectively located along leg 804 so that its be located in capture it is in tissue in nail and/or adjacent with tissue of the capture in nail Positioning.In some cases, nail leg 804 by deflection or the part contacted with anvil block may not include it is extending therefrom fall Hook.In at least some cases, the array of the barb extended from the inward-facing side of nail leg 804 can be longer than from nail leg 804 The array for the barb that the side faced out extends.In other cases, the barb extended from the inward-facing side of nail leg 804 Array can be shorter than the array of the barb extended from the side of nail leg 804 faced out.In still another case, from nail leg 804 The array for the barb that inward-facing side extends can be as the array for the barb that the side faced out from nail leg 804 extends It is long.

As described above, if nail leg 804 be deformity and/or it is unfashioned unintentionally, from nail leg 804 extend fall Hook can help to that holding will be followed closely within the organization.It is contemplated, however, that certain situations are arrived, including in barb disclosed herein One or more nails is inserted into tissue and keeps unfashioned intentionally.Under any circumstance, including it is disclosed herein The nail of one or more of barb can be used for suturing thick tissue.More particularly, in some cases, in nail bin and anvil block Between thickness and/or compact tissue presence and/or thickness and/or compact tissue in nail presence can anti-non-magnetic shim it is complete Forming or closure.For example, nail may be not completely closed at B form configuration, or nail may be not completely closed.In such situation Under, the barb of not closed nail may inhibit or tissue is prevented to be drawn out for example to follow closely.Along the barb of the extension of the length of nail leg Array allows leg to keep in the tissue, without the thickness of tubing.

It is contemplated that various embodiments, nail such as nail 800 with barb of the wherein at least one with barb is for example removable Except ground is stored in nail bin 22000 shown in nail bin such as Figure 10 to Figure 12.It is contemplated that wherein nail bin only includes with barb Certain embodiments of nail, while being susceptible to other embodiments using the nail with barb and the nail without barb.For example, the A line nail may include the nail with barb, and the second row nail may include the nail without barb.In some cases, it is stored in nail bin Nail can have identical or substantially the same unshaped height.At least referring to the nail of U-shape and/or V-arrangement shape, for example, The unshaped height of nail can be defined as the vertical distance between the bottom of base portion and the tip of nail leg of nail.Nail is inserted into nail Before in storehouse, it can be taken such before deflection when nail is removedly stored in nail bin, and/or in nail Measurement.In some cases, arrange that the nail with barb in the first row there can be the first unshaped height in nail bin, and The nail with barb being arranged in second row in nail bin can have the second unshaped height.The band in third row in nail bin The nail of barb can have the first unshaped height, the second unshaped height or third unshaped height.The first row, the second row and/ Or the nail with barb of the third line can be positioned on the same side for the cutter slit being defined in nail bin or the opposite side of cutter slit On.In use, the nail with barb being removedly stored in nail bin can be shaped as identical forming height or differing formed Highly.The forming height of nail can be defined as the total vertical distance followed closely after deflection at it.At least reference has become The nail for forming B form, for example, the forming height of nail can be measured between the bottom of the base portion of nail and the topmost portion of nail leg.? Under some cases, arrange that the nail with barb in the first row may be deformed to the first forming height in nail bin, and in nail bin In the nail with barb that is arranged in second row may be deformed to the second forming height.In third row in nail bin with barb Nail can have the first forming height, the second forming height or third forming height.The band of first row, second row and/or third row The nail of barb can be positioned on the same side for the cutter slit being defined in nail bin or on the opposite side of nail bin.As it will be appreciate that , it is shown in nail of the Figure 10 into Figure 12 and is reformed into differing formed height.Nail 800 with barb, which for example can be used to form, to be had not With in the nail bin and/or suture instruments of the staple of forming height.The nail 800 with barb of first row can be deformed into the first forming height Degree, and the nail 800 with barb of second row can be deformed into the second forming height.In all cases, the band barb of third row Nail 800 can be deformed into third forming height.In some cases, the nail 800 with barb for being deformed into different height can start In identical or substantially the same unshaped height.In some cases, it is deformed into the nail 800 with barb of differing formed height It can begin at different unshaped height.Various structures can be used for that nail is made to be configured to differing formed height.For example, support nail is movable Driver can at the different distance relative to anvil block support nail.In some cases, anvil block may include with different depths Nail shapes pit.In all cases, staple drivers may include bracket, the bracket be configured to the base portion of support nail and Nail is pushed up towards the forming pit being defined in anvil block.The forming height of nail can pass through the bottom surface and forming pit of bracket The distance between top surface determine.It is published in entitled " the SURGICAL STAPLING on November 27th, 2012 The United States Patent (USP) 8,317 of DEVICES THAT PRODUCE FORMED STAPLES HAVING DIFFERENT LENGTHS ", 070 is incorporated by.In some cases, the platform of nail bin may include stepped surface, as shown in Figure 1.First The nail cavity of row can be defined in the first ladder, and the nail cavity of second row can be defined in the second ladder, wherein the first ladder and Second ladder can deviate vertically each other.For example, the first ladder can be vertically positioned above anvil block, or more more than the second ladder Close to anvil positioning.In some cases, wall can be positioned between the first ladder and the second ladder.In some cases, nail bin Platform may include the first ladder, the second ladder being vertically positioned above the first ladder, and be vertically positioned at second Third ladder above ladder.It is contemplated that various embodiments, wherein the platform of nail bin includes any suitable number of ladder And any suitable number of wall between ladder.For example, the nail cavity of first row can be defined in the first ladder, second row Nail cavity can be defined in the second ladder and/or the nail cavity of third row can be defined in third ladder.For example, the first row Nail cavity may include the nail with the first unshaped height, and the nail cavity of second row may include the nail with the second unshaped height, and And/or the nail cavity of person's third row may include the nail with third unshaped height.It is contemplated that various embodiments, wherein nail bin Including any suitable number of staple with different unshaped height.For example, the nail in first row nail cavity can be deformed into first Forming height, the nail in second row nail cavity can be deformed into the second forming height and/or third nail chamber can be deformed into third Forming height.It is contemplated that various embodiments, wherein nail bin includes be deformed into differing formed height any suitable number of Staple.Other than with differing formed staple height or replace that there are different staple heights, the end effector of suture instruments can have There is different tissues gap.For example, gap can be limited at 22011 He of storehouse platform surface of nail bin usually referring to Figure 10 and Figure 11 Between the anvil block tissue compression surface 10063 of anvil block.The gap is configured to receive tissue T.It the gap can also be by structure It causes that tissue thickness compensation part can be received；However, the nail with barb can or can not be together with tissue thickness compensation part It uses, and is applicable to any case relative to the discussion that the nail with barb provides.Under any circumstance, reader will manage Solution, anvil block tissue compression surface 10063 is stepped.Anvil block tissue compression surface 10063 includes being vertically positioned at second The first part of upper.When end effector anvil block and nail bin in the closure state, as shown in figure 11, the first gap Distance is limited between the exterior section and storehouse platform surface 22011 on anvil block tissue compression surface 10063, and second is different Clearance distance is limited between the interior section and storehouse platform surface 22011 on anvil block tissue compression surface 10063.First clearance gap From being illustrated as being greater than the second clearance distance, but the first clearance distance is possible to shorter than the second clearance distance.With compared with short air gap away from It is more compressed than with the tissue with a distance from larger gap from the tissue being compressed between anvil block and nail bin.For example, the nail with barb 800 barb can differently engage tissue, this depends on tissue and is located in shorter tissue space or larger tissue space.More Specifically, the tissue being compressed in shorter tissue space can be sought after end effector release than being compressed in larger group at it The tissue knitted in gap is unfolded more again, and the barb of the nail with barb can inhibit or resist this and is unfolded again, this depends on In its configuration and/or the position on barb.In other cases, barb is configured to and/or is positioned to do not inhibit Or the expansion again of resisted organize.As it will be appreciate that, anvil block tissue compression surface 10063 is stepped, and storehouse is flat Platform surface is flat or at least substantially flat, and therefore, be limited to the difference of the tissue space in end effector with The height of staged anvil faces and change.It is contemplated that other embodiments.For example, anvil block tissue compression surface can be flat Or it is at least substantially flat, and storehouse platform surface can be stepped.In other cases, anvil block tissue compression surface and Storehouse platform surface can be stepped.Under any circumstance, different gap distance can be limited to anvil block tissue compression surface and Between storehouse platform surface.Although two clearance distances are shown in Figure 10 and Figure 11, possibly more than two clearance distances, Such as three clearance distances.The forming pit of 0 and Figure 11 referring to Fig.1, first longitudinal direction row may be arranged at having for end effector In the first part of the first tissue clearance distance, and the forming pit of second longitudinal direction row may be arranged at having for end effector Different from the second part of the minor microstructure clearance distance of the first tissue clearance distance.In some cases, end effector It may include the forming pit that third is longitudinally arranged, be arranged in end effector has different from the first tissue clearance distance and the In the Part III of the third tissue space distance of two tissue space distances.In some cases, end effector may include Three forming pits longitudinally arranged, be arranged in end effector has and the first tissue clearance distance or minor microstructure clearance gap In the Part III with a distance from identical tissue space.It will be appreciate that end effector can have different tissues clearance distance And/or differing formed staple height.End effector can have one, another one, or both have concurrently.In some cases, compared with Short forming nail height can be associated with shorter tissue space distance, and larger forming nail height can be with larger tissue space apart from phase Association.In other cases, shorter forming nail height can be associated with larger tissue space distance, and larger forming nail height can It is associated with shorter tissue space distance.Further described above, nail can have U-shape in its unshaped state Configuration.The nail of U-shape may include base portion and two nail legs from base portion extension, and wherein nail leg extends to that along parallel direction This.In addition further described above, nail may include V-arrangement shape configurations in its unshaped state.V-arrangement shape configurations can Including base portion and two nail legs extended from base portion, wherein nail leg extends along not parallel direction.Various implementations as described herein Up and down described in the text of the scheme in linear end effector and/or linear fastener storehouse.Such embodiment and its teaching content It can be applied to nonlinear end actuator and/or non-linear fastener cartridge, such as round and/or contoured end effector. E.g., including the various end effectors of nonlinear end actuator were on 2 28th, the 2011 entitled " SURGICAL submitted The U.S. Patent Application Serial Number 13/036,647 of STAPLING INSTRUMENT " (is now U.S. Patent Application Publication 2011/ 0226837) disclosed in having in, which is incorporated by accordingly.In addition, the title submitted on the 29th of September in 2012 It (is now U.S. Patent Application Publication 2012/ for the U.S. Patent Application Serial Number 12/893,461 of " STAPLE CARTRIDGE " 0074198) it is incorporated by accordingly.Entitled " the END EFFECTORS FOR A submitted on 2 15th, 2008 SURGICAL CUTTING AND STAPLING INSTRUMENT " U.S. Patent Application Serial Number 12/031,873 (now for United States Patent (USP) 7,980,443) also it is incorporated by accordingly.Entitled " the SURGICAL that on December 7th, 2010 announces The complete disclosure of the United States Patent (USP) 7,845,537 of INSTRUMENT HAVING RECORDING CAPABILITIES " with Way of reference is incorporated herein.Entitled " the SURGICAL STAPLING INSTRUMENTS WITH submitted on May 27th, 2011 The Application U.S. Serial No 13/118,241 of ROTATABLE STAPLE DEPLOYMENT ARRANGEMENTS " (is now the U.S. Patent application publication 2012/0298719) complete disclosure be herein incorporated by reference.

Apparatus as disclosed herein can be designed as being processed after a single use, or they may be designed to can be more Secondary use.However no matter what kind of situation it is, which all can be at least using exercising use by repairing after primary again.Again it repairs It may include any combination in following steps: dismantling the device, then clean or replace specific component and subsequent group again Dress.Specifically, which can dismantle, and selectively can replace or remove in any combination any number of particular elements Or part.After cleaning and/or replacement specific component, which can be re-assemblied at the repair facility then to use, or Person is re-assemblied by surgical team immediately before surgery.It will be understood by those of skill in the art that device is again Repair can utilize it is a variety of be used to dismantle, the technology for cleaning/replace and re-assembly.The purposes of such technology and it is resulting again Prosthetic device is within the scope of the present invention.

Preferably, invention as described herein will be handled before surgery.Firstly, obtaining new or used instrument, and root According to being cleaned.Then it can sterilize to instrument.In a kind of sterilization technology, which is placed on closure and sealing Container in, in such as plastics or TYVEK bag.Then container and instrument are placed on to the radiation field such as γ that can penetrate the container In radiation, x- ray or high energy electron.The bacterium on instrument and in container is killed in radiation.Then the instrument after sterilizing can be stored In sterile chamber.The sealing container makes instrument keep sterile until opening the container in medical facilities.

Any patent, announcement or other public materials incorporated in this article in full or in part by reference only simultaneously The material entered is not incorporated herein in existing definition described in the disclosure, statement or the conflicting range of other public materials.Cause This, and at the necessary level, the disclosure being expressly recited herein replaces any conflict being herein incorporated by reference Material.It is any to be herein incorporated by reference but conflicting with existing definition as described herein, statement or other public materials Any material or part thereof does not only generate between the incorporated material and the existing public material and is incorporated to this under the degree of conflict Text.

It, can also be right in the spirit and scope of the disclosure although the present invention has been described as having illustrative design The present invention modifies.Therefore this application is intended to cover any modification, purposes or the modified versions using general principles. In addition, this application is intended to cover belong to known or used this different from the disclosure having in practical framework in fields of the present invention Class pattern.

Claims

1. a kind of method for changing the tissue thickness compensation part being used together with surgical instruments, the method includes following steps It is rapid:

Tissue thickness compensation part is obtained, the tissue thickness compensation part is at least partly by including glass transition temperature and melting The material of temperature is constituted, wherein the tissue thickness compensation part includes first shape；

The material is heated to above the glass transition temperature and is lower than the temperature of the melting temperature；

Apply modification component towards side to the tissue of the tissue thickness compensation part；

Using the modification component, by drawing in a part of the tissue thickness compensation part contacted with the modification component Enter part to change and the tissue thickness compensation part is manipulated to the second shape different from the first shape；

The material is set to be cool below the glass transition temperature；And

The modification component is discharged from the part of the tissue thickness compensation part.

2. according to the method described in claim 1, the step for wherein obtaining the tissue thickness compensation part includes following step It is rapid:

Obtain the biocompatible polymer including glass transition temperature and melting temperature；

The biocompatible polymer is dissolved in solvent to generate solution；And

The solution is lyophilized.

3. according to the method described in claim 1, the step for wherein manipulating the tissue thickness compensation part includes will at least One compressing force is applied to the tissue thickness compensation part.

4. according to the method described in claim 1, the step for wherein manipulating the tissue thickness compensation part includes will at least One pulling force is applied to the tissue thickness compensation part.

5. according to the method described in claim 1, further including being actively cooled the tissue thickness compensation part through manipulating The step of lower than the glass transition temperature.

6. a kind of customization tissue thickness compensation part being used together with surgical stapling device, wherein the customization tissue thickness compensation part It is prepared by the treatment process included the following steps:

Obtain the tissue thickness compensation part including first shape；

At least part of the tissue thickness compensation part is transformed into glassy state from original state；

Using modification component, pass through the introducing office in a part of the tissue thickness compensation part contacted with the modification component Portion changes and described at least part of the tissue thickness compensation part is manipulated to the second shape；

Described at least part of the tissue thickness compensation part is set to be restored to non-glass state from the glassy state；And

The modification component is discharged from described at least part of the tissue thickness compensation part.

7. customization tissue thickness compensation part according to claim 6, wherein obtaining the described of the tissue thickness compensation part Step the following steps are included:

The biocompatible polymer is dissolved in solvent to generate solution；And

The solution is lyophilized.

8. customization tissue thickness compensation part according to claim 6, wherein manipulating the described of the tissue thickness compensation part At least part of step includes being applied at least one compressing force at least one described in the tissue thickness compensation part Part.

9. customization tissue thickness compensation part according to claim 6, wherein manipulating the described of the tissue thickness compensation part At least part of step includes that at least one pulling force is applied to described in the tissue thickness compensation part at least one Point.

10. customization tissue thickness compensation part according to claim 6, wherein the treatment process is the following steps are included: main Described at least part of the cooling tissue thickness compensation part dynamicly, by described in the tissue thickness compensation part at least one Part moves to the non-glass state from the glassy state.

11. customization tissue thickness compensation part according to claim 6, wherein the treatment process will be the following steps are included: will At least part of manipulation of the tissue thickness compensation part maintains one section to be enough that the tissue thickness is allowed to compensate Described at least part of part maintains the time of the manipulation.