CN106215313A - A kind of drug device - Google Patents

A kind of drug device Download PDF

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Publication number
CN106215313A
CN106215313A CN201610576776.7A CN201610576776A CN106215313A CN 106215313 A CN106215313 A CN 106215313A CN 201610576776 A CN201610576776 A CN 201610576776A CN 106215313 A CN106215313 A CN 106215313A
Authority
CN
China
Prior art keywords
medicine
discharging nozzle
drug device
medicine discharging
scraping plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610576776.7A
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Chinese (zh)
Inventor
姜玉峰
朱洪民
吴大卫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiang Yufeng
TIANJIN ZHONGJIAN AIHE MEDICAL TECHNOLOGY Co.,Ltd.
Original Assignee
TIANJIN ZHONGJIAN AIHE MEDICAL TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TIANJIN ZHONGJIAN AIHE MEDICAL TECHNOLOGY Co Ltd filed Critical TIANJIN ZHONGJIAN AIHE MEDICAL TECHNOLOGY Co Ltd
Priority to CN201610576776.7A priority Critical patent/CN106215313A/en
Publication of CN106215313A publication Critical patent/CN106215313A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

The invention discloses a kind of drug device, it is characterized in that, described drug device is provided with medicine-storing tube, described medicine-storing tube is cavity structure, described medicine-storing tube is soft-shell, described medicine-storing tube one end is closed, the other end is provided with the circular medicine outlet of protrusion, the outer wall of described medicine outlet is provided with external screw thread, described medicine outlet has Gask-O-Seal, described medicine outlet is provided with headkerchief, described drug device includes connecting portion and medicine discharging nozzle, described drug device is cavity structure, described connecting portion inwall is provided with the female thread matched with external screw thread, described medicine discharging nozzle is flat oblique mouth shape, its slanted angle α is 0~40 °, present configuration is simple, heteroid drug device is applicable to different affected parts shape, and cross infection will not be produced, reduce and change dressings the time, accelerate affected part healing.

Description

A kind of drug device
Technical field
The invention belongs to medical supplies field, be specifically related to a kind of drug device.
Background technology
Diabetics merges too high mechanical pressure because of peripheral neuropathy with peripheral blood vessel, and foot can be caused soft Tissue and the destruction of osteoarticular system and teratogenesis, and then cause a series of foot problems, from slight nervous symptoms to sternly The ulcer of weight, infection, angiopathy, Charcot arthrosis and Neuropathic fracture.If active treatment can not fully solve The symptom of lower limb appearance and complication, then can cause catastrophic consequence.Therefore, carry out foot problems in diabetics Early prevention and treatment will have important meaning.
Interior application treatment diabetes, take effect slow, and toxic and side effects is big, increases liver load, and therapeutic process patient is the most painful.Mesh Occurring in that all kinds of medicine for external use on front market, be applied in foot, can slow down disease, this kind of external-applied ointment is placed in ointment shell more, Open lid during use, directly spread upon affected part, and the foot affected part shape of different diabetics is different, have for ulcer, Serious may rot into hole, and simple ointment shell is not applied for different affected parts, and an ointment can be used for multiple times, meeting Cause infection, increase the weight of disease, the cicatrix after the uneven healing time that also can affect affected part of the smearing thickness of ointment and healing, Therefore design a kind of special drug device, improve the shortcoming that prior art Chinese medicinal ointment is smeared.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of drug device, present configuration is simple, heteroid Drug device is applicable to different affected parts shape, and will not produce cross infection, reduces and changes dressings the time, accelerates affected part healing.
The technical scheme is that a kind of drug device, it is characterised in that described drug device is provided with medicine-storing tube, described Medicine-storing tube is cavity structure, and described medicine-storing tube is soft-shell, and described medicine-storing tube one end is closed, and the other end is provided with the circle of protrusion and goes out Medicine mouth, the outer wall of described medicine outlet is provided with external screw thread, and described medicine outlet has Gask-O-Seal, and described medicine outlet is provided with Headkerchief, described drug device includes that connecting portion and medicine discharging nozzle, described drug device are cavity structure, and described connecting portion inwall is provided with outward The female thread that screw thread matches, described medicine discharging nozzle is flat oblique mouth shape, and its slanted angle α is 0~40 °.
As preferably, described medicine discharging nozzle can also is that flat beak shape drug device, point mouth shape medicine discharging nozzle and belt scraping plate medicine discharging nozzle In any one.
As preferably, described point mouth shape medicine discharging nozzle is cone, and described point mouth shape medicine discharging nozzle one end is connected with connecting portion, The other end is round exit, and the cross section of described round exit is circular.
As preferably, the internal diameter of described round exit is 1-5.
As preferably, the internal diameter of described round exit is 2-3.
As preferably, described medicine discharging nozzle is belt scraping plate medicine discharging nozzle, and described belt scraping plate medicine discharging nozzle one end is connected with connecting portion, The other end is belt scraping plate outlet, and described belt scraping plate medicine discharging nozzle includes two side plates, upper scraping plate and lower shoe, and described upper scraping plate is long Degree is more than described lower shoe length, and the lumen thickness 5mm of medicine discharging nozzle, the width of medicine discharging nozzle is 10mm, the drug of described medicine outlet End is inclined-plane.
As preferably, the lumen width of described flat beak shape drug device is 5-15, and lumen thickness is 1-4.
As preferably, the lumen width of described flat beak shape drug device is 10, and lumen thickness is 2.
As preferably, the material of described Gask-O-Seal is medical silica-gel.
The beneficial effects of the present invention is:
1, medicine-storing tube can be used for storing ointment, backs out headkerchief, when foot disease affected part is ulcer, can flat be gone out during use Medicine mouth or belt scraping plate medicine discharging nozzle, be connected with medicine-storing tube by connecting portion, extrudes ointment, smears ulcer, and flat goes out Medicine mouth adds an application area, improves and smears efficiency;When ulcer is smeared by belt scraping plate medicine discharging nozzle, lower shoe is leaned on Nearly affected part, extrudes ointment, and owing to upper scraping plate length is more than described lower shoe length, while smearing, ointment can be entered by upper scraping plate Row strikes off and smoothens process, it is not necessary to secondary smoothens, and significantly reduces the misery of patient when smearing.
2, medicine-storing tube can also be used to store the cleaning liquid medicine such as saline, backs out headkerchief, when foot disease affected part is rotten during use Hole time, need to use the cleaning liquid medicine disinfection such as saline, point mouth shape medicine discharging nozzle can be used, due to point mouth shape drug Mouth is cone, and round exit diameter is less, can go deep into inside hole, extrudes medicine-storing tube, extrudes saline, deep to carrying out at hole Gradation processing;When storing ointment in medicine-storing tube, it is possible to use point mouth shape medicine discharging nozzle is smeared inside rotten hole simultaneously, Add the process degree of depth of ointment.
3, the present invention is applicable to the affected part without shape, and can be replaced drug device, reduces infection risk.
4, through testing the thickness of the medicine outlet obtained and smearing angle, medical personnel or family numbers of patients can be greatly improved The speed of coating, and smear uniformly, experiment shows, the thickness of covering of the medicine outlet that the present invention relates to can accelerate healing of affected part Close, use this drug utensil to have prominent effect.
Accompanying drawing explanation
Fig. 1 is the structural representation of medicine-storing tube.
Fig. 2 is flat beak shape medicine discharging nozzle structural representation.
Fig. 3 is point mouth shape medicine discharging nozzle structural representation.
Fig. 4 be point mouth shape medicine discharging nozzle and medicine-storing tube with the use of time schematic diagram
Fig. 5 is belt scraping plate medicine discharging nozzle structural representation.
Fig. 6 be belt scraping plate medicine discharging nozzle with medicine-storing tube with the use of time schematic diagram.
Fig. 7 is the structural representation of flat oblique mouth shape medicine discharging nozzle.
Wherein: 1, medicine-storing tube 2, medicine outlet 3, external screw thread 4, Gask-O-Seal
5, headkerchief 6, connecting portion 7, female thread 8, tilt outlet
9, pancake outlet 10, point mouth shape medicine discharging nozzle 11, round exit 12, belt scraping plate medicine discharging nozzle
13, belt scraping plate outlet 14, side plate 15, upper scraping plate 16, lower shoe
Detailed description of the invention
Below in conjunction with the accompanying drawings the detailed description of the invention of the present invention is made brief description.
Embodiment one
As shown in Figure 1, 2, a kind of drug device, described drug device is provided with medicine-storing tube 1, and described medicine-storing tube 1 is cavity structure, Described medicine-storing tube 1 is soft-shell, and described medicine-storing tube 1 one end is closed, and the other end is provided with the circular medicine outlet 2 of protrusion, described drug The outer wall of mouth 2 is provided with external screw thread 3, and described medicine outlet 2 has Gask-O-Seal 4, and the material of described Gask-O-Seal 4 is doctor With silica gel, described medicine outlet 2 is provided with headkerchief 5, and described drug device includes that connecting portion 6 and medicine discharging nozzle, described drug device are cavity Structure, described connecting portion 6 inwall is provided with the female thread 7 matched with external screw thread 3, and described medicine discharging nozzle is flat beak shape medicine discharging nozzle, institute Stating flat beak shape medicine discharging nozzle one end to be connected with connecting portion 6, the other end is pancake outlet 9, and the cross section of described pancake outlet 9 is Rectangle, the lumen width of described flat beak shape drug device is 5-15, preferably 10, lumen thickness is 1-4, preferably 2 ㎜。
This medicine discharging nozzle is applicable at ulcer smear, and flat medicine discharging nozzle adds an application area, improves and smears effect Rate.
Embodiment two
As shown in Figure 3,4, medicine-storing tube is identical with embodiment one, and difference is that described medicine discharging nozzle is for point mouth shape medicine discharging nozzle 10, described point mouth shape medicine discharging nozzle 10 is cone, and described point mouth shape medicine discharging nozzle 10 one end is connected with connecting portion 6, and the other end is circle Shape outlet 11, the internal diameter of described round exit is 1-5, it is preferable that the internal diameter of described round exit is 2-3, described circle The cross section of outlet 11 is circular, and owing to point mouth shape medicine discharging nozzle is cone, round exit diameter is less, can go deep in hole Portion, extrudes medicine-storing tube, extrudes saline, to carrying out profound process at hole;When storing ointment in medicine-storing tube simultaneously, it is possible to use Point mouth shape medicine discharging nozzle is smeared inside rotten hole, adds the process degree of depth of ointment.
Embodiment three
As shown in Figure 5,6, medicine-storing tube is identical with embodiment one, and difference is that described medicine discharging nozzle is belt scraping plate medicine discharging nozzle 12, described belt scraping plate medicine discharging nozzle 12 one end is connected with connecting portion 6, and the other end is belt scraping plate outlet 13, described belt scraping plate outlet 13 Including two side plates 14, upper scraping plate 15 and lower shoe 16, described upper scraping plate 15 length is more than described lower shoe 16 length, due to upper Scraper plate length is more than described lower shoe length, and while smearing, ointment can be struck off and smoothen process by upper scraping plate, it is not necessary to Secondary smoothens, and significantly reduces the misery of patient when smearing, the lumen thickness 5mm of medicine discharging nozzle, and the width of medicine discharging nozzle is 10mm, institute The medicine outlet end stating medicine outlet is inclined-plane.
Embodiment four:
As it is shown in fig. 7, medicine-storing tube is identical with embodiment one, difference is that described medicine discharging nozzle is flat oblique mouth shape, its Slanted angle α is 0~40 °, and optimal angle is 30 °, and described flat oblique mouth shape medicine discharging nozzle one end is connected with connecting portion 6, the other end For tilt outlet 8.
Embodiment five:
As a example by the dressing changing device of embodiment four, carry out following clinical experiment:
Choose 60 example patient with diabetic feet, be randomly divided into 2 groups, administrator group 30 example, route dressing change group 30 example.
Administrator group mode of dressing change (A): before administration, is connected to ointment medicine outlet by administrator, at the uniform velocity will with 0.5cm/m speed Ointment is released, with evenly laid out in wound surface and to exceed wound surface skin edge and wound surface intersection 0.5cm be suitable.Outer layer medical aseptic yarn Cloth is wrapped up, and each group is changed dressings 1 time for every 2 days, normal saline cleaning wound surface before being administered.
Route dressing change group mode of dressing change (B): according to doctors experience, release after suitable dose ointment with cotton swab uniform application in Wound surface, thickness is about 0.5cm, is suitable beyond wound surface skin edge and wound surface intersection 0.5cm. and outer layer medical sterile gauze is wrapped up, Each group is changed dressings 1 time for every 2 days, normal saline cleaning wound surface before being administered.
Inclusive criteria: 18 one full year of life≤age≤80 one full year of life;Type 2 diabetes mellitus patient;As deep as subcutaneous ulcer below ankle;Vein is empty Abdomen blood glucose≤10mmol/L;Target ulcer at least exist 4 weeks before entering group and more than;After debridement ulcerous skin defect area 1~ 20cm2;Signature informed consent;Aspiration participates in test.
Exclusion standard: have malignant change at skin ulcer that the other reasons such as electricity, chemistry, radioactivity causes and ulcer;Mesh < 1cm2 or > 20cm2 after mark ulcer debridement;Ulcer side limbs ankle-brachial arterial pressure ratio (ABI) < 0.6 or > 1.3;Ulcer , there is sequestrum at the end and infects the removing of bone non-underwent operative;Varicose ulcer;Hemoglobin (HB) < 90g/L;Serum albumin (ALB)<25g/L;Blood pressure >=180/110mmHg;Gestation or age of sucking;Used in three month radiation, hormone, chemotherapy, growth because of Subclass dressing and immunosuppressant;Known related drugs allergies;Severe cardiac function, liver function and renal dysfunction (cardiac function According to NYHA classification >=3 grade, normal 1.5 times of normal 2.5 times of liver function ALT >, Cr >);Cancer patient;Mental disorder or old silly Slow-witted;Clinical drug trials was participated in nearly 3 months;Fail during code test by regulation medication or the person of dropping by the wayside.
2 trial drugs: JINGWANHONG RUANGAO: Tianjin Darentang Wanhong Pharmaceutical Co., Ltd produces.Specification: cream system Agent, performs standard WS3-B-3063-98-2008 by 20 grams/;Authentication code: traditional Chinese medicines quasi-word Z12020440 lot number, 211874.
3 projects:
Each center primary dcreening operation meets 60 example diabetic foot ulcer patients of inclusive criteria, and completely random is divided into test group (A) With matched group (B).Tracing wound surface along skin edge-granulation intersection hyaline membrane, image analysis software MIAS2000 is analyzed, and calculates wound surface Area.According to Healing Rate=(baseline area-time point measured area)/baseline area, when calculating 2,5,10,15,20 weeks respectively Point Healing Rate.
4 statistical methods
Statistical analysis all uses SPSS v12.0 software, and two-sided test has statistical significance, measurement data with P≤0.05 difference With ± SD description.
2. result:
2.1 base-line data
Two groups of subject age, sex, the course of disease, liver function, renal function base-line data no difference of science of statistics (table 1).
2.2 curative effect index
2.2.1 Healing Rate: at 2,5,10,15 weeks time points, administrator group is better than route dressing change group, and the 5th week, 10 All 2 time points, trend becomes apparent from P < 0.01 (table 2).
2.2.2 complete healing time: it is 34.7 ± 17.5 days that administrator group wound surface reaches complete epithelization average time, often Rule are changed dressings group 46.2 ± 21.4 days, the extremely notable P < 0.0001 of significant difference.
Table 1: base-line data compares
Table 2: each time point wound healing speed ratio is relatively
*P < 0.05,#P < 0.01, compares with route dressing change group
Testing time shortening of changing dressings after showing to use this drug device, wound healing accelerates.
Above one embodiment of the present of invention is described in detail, but described content has been only the preferable enforcement of the present invention Example, it is impossible to be considered the practical range for limiting the present invention.All impartial changes made according to the present patent application scope and improvement Deng, within all should still belonging to the patent covering scope of the present invention.

Claims (9)

1. a drug device, it is characterised in that described drug device is provided with medicine-storing tube, described medicine-storing tube is cavity structure, described Medicine-storing tube is soft-shell, and described medicine-storing tube one end is closed, and the other end is provided with the circular medicine outlet of protrusion, the outer wall of described medicine outlet Being provided with external screw thread, described medicine outlet has Gask-O-Seal, and described medicine outlet is provided with headkerchief, and described drug device includes even Connecing portion and medicine discharging nozzle, described drug device is cavity structure, and described connecting portion inwall is provided with the female thread matched with external screw thread, institute Stating medicine discharging nozzle is flat oblique mouth shape, and its slanted angle α is 0~40 °.
A kind of drug device the most according to claim 1, it is characterised in that described medicine discharging nozzle can also is that flat beak shape drug Device, point mouth shape medicine discharging nozzle and belt scraping plate medicine discharging nozzle in any one.
A kind of drug device the most according to claim 2, it is characterised in that described point mouth shape medicine discharging nozzle is cone, described Point mouth shape medicine discharging nozzle one end is connected with connecting portion, and the other end is round exit, and the cross section of described round exit is circular.
A kind of drug device the most according to claim 3, it is characterised in that the internal diameter of described round exit is 1-5.
A kind of drug device the most according to claim 4, it is characterised in that the internal diameter of described round exit is 2-3.
A kind of drug device the most according to claim 2, it is characterised in that described medicine discharging nozzle is belt scraping plate medicine discharging nozzle, described Belt scraping plate medicine discharging nozzle one end is connected with connecting portion, the other end be belt scraping plate outlet, described belt scraping plate medicine discharging nozzle include two side plates, Upper scraping plate and lower shoe, described upper scraping plate length be more than described lower shoe length, the lumen thickness 5mm of medicine discharging nozzle, medicine discharging nozzle Width is 10mm, and the medicine outlet end of described medicine outlet is inclined-plane.
A kind of drug device the most according to claim 2, it is characterised in that the lumen width of described flat beak shape drug device is 5- 15, lumen thickness is 1-4.
A kind of drug device the most according to claim 8, it is characterised in that the lumen width of described flat beak shape drug device is 10 , lumen thickness is 2.
A kind of drug device the most according to claim 1, it is characterised in that the material of described Gask-O-Seal is medical silicon Glue.
CN201610576776.7A 2016-07-19 2016-07-19 A kind of drug device Pending CN106215313A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111893670A (en) * 2020-08-05 2020-11-06 苏州棠华纳米科技有限公司 Dyeing and finishing integrated production equipment for textiles and use method thereof

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CN1355678A (en) * 1999-04-23 2002-06-26 荷兰联合利华有限公司 Package for dispensing flowable cosmetic composition and product
US20020127045A1 (en) * 2001-03-12 2002-09-12 Cookfair John L. Bingo card marker
JP2004002271A (en) * 2001-09-29 2004-01-08 Mochida Pharmaceut Co Ltd Topical styptic medicine composition sealed in flexible container
CN201042558Y (en) * 2007-06-11 2008-04-02 范立娟 Externally used medical ointment applicator
CN203029818U (en) * 2012-11-26 2013-07-03 姚晓明 Portable nebulizer device
CN203123310U (en) * 2013-02-05 2013-08-14 孙鸿涛 Medical daubing head and applicator with medical daubing head utilized
WO2014014201A1 (en) * 2012-07-16 2014-01-23 우석대학교 산학협력단 Tubular liquid cosmetics container provided with soft brush
CN204745336U (en) * 2015-06-10 2015-11-11 北京大学第三医院 Medicament coating device
CN206167629U (en) * 2016-07-19 2017-05-17 天津众健爱和医疗科技有限公司 Go out medicine ware

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4787429A (en) * 1986-07-25 1988-11-29 Farmitalia Carlo Erba S.P.A. Device for coupling a small tube to an apparatus adapted for fitting a syringe to a drug holding bottle
CN1355678A (en) * 1999-04-23 2002-06-26 荷兰联合利华有限公司 Package for dispensing flowable cosmetic composition and product
US20020127045A1 (en) * 2001-03-12 2002-09-12 Cookfair John L. Bingo card marker
JP2004002271A (en) * 2001-09-29 2004-01-08 Mochida Pharmaceut Co Ltd Topical styptic medicine composition sealed in flexible container
CN201042558Y (en) * 2007-06-11 2008-04-02 范立娟 Externally used medical ointment applicator
WO2014014201A1 (en) * 2012-07-16 2014-01-23 우석대학교 산학협력단 Tubular liquid cosmetics container provided with soft brush
CN203029818U (en) * 2012-11-26 2013-07-03 姚晓明 Portable nebulizer device
CN203123310U (en) * 2013-02-05 2013-08-14 孙鸿涛 Medical daubing head and applicator with medical daubing head utilized
CN204745336U (en) * 2015-06-10 2015-11-11 北京大学第三医院 Medicament coating device
CN206167629U (en) * 2016-07-19 2017-05-17 天津众健爱和医疗科技有限公司 Go out medicine ware

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111893670A (en) * 2020-08-05 2020-11-06 苏州棠华纳米科技有限公司 Dyeing and finishing integrated production equipment for textiles and use method thereof
CN111893670B (en) * 2020-08-05 2023-09-26 苏州棠华纳米科技有限公司 Dyeing and finishing integrated production equipment for textiles and application method thereof

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Address after: 300462 Tianjin Heping Development Zone West District South Street 175 Training Workshop 8-2-1 Floor

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Application publication date: 20161214