CN106215163A - A kind of Chinese medicine decoction for treating bile reflux gastritis - Google Patents

A kind of Chinese medicine decoction for treating bile reflux gastritis Download PDF

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CN106215163A
CN106215163A CN201610787802.0A CN201610787802A CN106215163A CN 106215163 A CN106215163 A CN 106215163A CN 201610787802 A CN201610787802 A CN 201610787802A CN 106215163 A CN106215163 A CN 106215163A
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parts
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herba
rhizoma
radix
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卞永兴
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    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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    • A61K36/88Liliopsida (monocotyledons)
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    • A61K36/906Zingiberaceae (Ginger family)
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a kind of Chinese medicine decoction for treating bile reflux gastritis, the Chinese crude drug of following weight proportion be prepared from: 7 parts of Cassia siamea leaf, wild Fructus Kaki 15 parts, Herba brassicae narinosae 16 parts, tragacanth 6 parts, Herba Portulacae 9 parts, Rhizoma Coptidis 8 parts, Radix seu Herba Gei aleppici 10 parts, Rhizoma Zingiberis 12 parts, Radix Codonopsis 5 parts, Cortex Magnoliae Officinalis 8 parts, Radix Bupleuri 12 parts, Herba Lysimachiae 10 parts, Radix Salviae Miltiorrhizae 5 parts, Fructus Aurantii Immaturus 12 part, month laural cherry 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Fructus Aurantii 5 parts, Rhizoma Sparganii 6 parts, Tronae 12 parts, Heterolamium debile 14 parts, gomuti fibre 10 parts, Fructus Liquidambaris 13 parts, Semen pegani harmalae 5 parts, Herba Saussureae amarae 4 parts.Clinical trial certificate, the present invention reasonable compatibility by Chinese crude drug, contribute to treating bile reflux gastritis, and can effectively prevent recurrence, reach integrally-regulated and long-term effect good effects.

Description

A kind of Chinese medicine decoction for treating bile reflux gastritis
Technical field
The present invention relates to a kind of Chinese medicine decoction, be specifically related to a kind of Chinese medicine decoction for treating bile reflux gastritis.
Background technology
Bile reflux gastritis, as the commonly encountered diseases of digestive system, has higher sickness rate clinically, and shows Unresolved and repetitious feature, physiology and psychology to patient all cause serious harm river.Conventional Chinese traditional treatment, only It is difficult to look after comprehensively with several taste medicines, multi-medicament suitably must be coordinated, improve curative effect or reduce untoward reaction, multiple to adapt to The treatment of miscellaneous diseases feelings.In view of the various active composition interaction in vivo of various Chinese crude drugs is sufficiently complex, various medicines exist The change of the aspects such as internal pharmacokinetics and pharmacodynamics can produce various impacts to the interaction between medicine, and medicine joins Used time, both may produce the drug effect of Synergistic, it is also possible to produce antagonism, and then cause Drug therapy declines or control Treating unsuccessfully, some drug combination also can make drug toxicity strengthen, and causes untoward reaction;Even if drug combination makes effect increase By force, but the tolerant ability of body can be exceeded when therapeutical effect excessively strengthens, it is possible to cause untoward reaction, or even harm suffered from Person.Part research to treatment bile reflux gastritis, the most easily problem appear to is that the compatibility of medicines in a prescription toward plan Chinese medicinal formulae certainly Unreasonable, may often be such that only to cure mainly from some single or polypharmaceutic discrete function and go to copy mechanically and apply indiscriminately the traditional Chinese medical science with some pharmacodynamic index Pharmacology opinion, prescription flavour of a drug are arbitrarily added and subtracted, and cause prescription unreasonable, contradict with Chinese medical theory.
Summary of the invention
It is desirable to provide a kind of Chinese medicine decoction for treating bile reflux gastritis, by the Reasonable of Chinese crude drug 5, contribute to treating bile reflux gastritis, and can effectively prevent recurrence, reach integrally-regulated and long-term effect good merit Effect.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine decoction for treating bile reflux gastritis, is prepared from by the Chinese crude drug of following weight proportion: ferrum cutter 7 parts of leaf of wood, wild Fructus Kaki 15 parts, Herba brassicae narinosae 16 parts, tragacanth 6 parts, Herba Portulacae 9 parts, Rhizoma Coptidis 8 parts, Radix seu Herba Gei aleppici 10 parts, Rhizoma Zingiberis 12 parts, Radix Codonopsis 5 parts, Cortex Magnoliae Officinalis 8 parts, Radix Bupleuri 12 parts, Herba Lysimachiae 10 parts, Radix Salviae Miltiorrhizae 5 parts, Fructus Aurantii Immaturus 12 part, month laural cherry 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Fructus Aurantii 5 parts, Rhizoma Sparganii 6 parts, Tronae 12 parts, Heterolamium debile 14 parts, gomuti fibre 10 parts, Fructus Liquidambaris 13 parts, Semen pegani harmalae 5 parts, Herba Saussureae amarae 4 Part.
Preparation method is: above-mentioned pulverizing medicinal materials in addition to Tronae, tragacanth is become coarse powder;Decoct twice, for the first time Decoction adds water 8 times amount, soaks 2h, decocts 3h, filters;Second time decocts 6 times amount that add water, and decocts 2h, filters;Merge twice to decoct Liquid mix homogeneously with Tronae, tragacanth again after subpackage.
Further, above-mentioned Chinese medicine decoction purposes in preparation treatment or prevention bile reflux gastritis medicine.
The pharmacology analysis of each Chinese medicinal ingredients of the present invention is as follows:
The dry lobule of Cassia siamea leaf [source] leguminosae cassia plant Cassia siamea.[nature and flavor] bitter in the mouth, cold in nature, enter water, Feng Ta. [function cures mainly] expelling wind and removing dampness, reducing swelling and alleviating pain, killing parasites for relieving itching.
Tragacanth [source] is leguminous plant Calculus Bovis from Northwest of China stilbene and belongs to him together and plant the glue fat of plant.[nature and flavor] are flat, the wettest, taste Light.[function cures mainly] corrects the evil of hundred tastes, raw moistening lung, cough-relieving, hemostasis, sore throat relieving profit larynx, tonneau urine, and antiinflammatory is healed skin ulcer.Cure mainly Dryness contains caused various diseases partially, and such as dryness of the lung dry cough, dry laryngopharynx, hoarseness, intestinal ulcer, urethra skin infection, urine is burnt Heat.
Herba Portulacae [source] this product is portulacaceous plant Herba Portulacae, with all herbal medicine.[nature and flavor] acid;Cold in nature.[return Warp] large intestine;Liver Channel.[function cures mainly] heat-clearing and toxic substances removing;Eliminating pathogenic heat from blood to cure dysentery;Dehumidify treating stranguria.Main pyretic toxicity dysentery;Pyretic stranguria;Urine retention;Red Under leucorrhea;Metrorrhagia;Hemorrhoidal bleeding;Skin infection carbuncle furuncle;Erysipelas;Scrofula;Exudative dermatitis;The baldst.
Rhizoma Coptidis [source] ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or the dry rhizome of Coptis Teeta Wall.[function cures mainly] heat clearing away is dry Wet, eliminating fire and detoxication.For damp and hot feeling of fullness, vomitting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told Nosebleed, conjunctival congestion, toothache, quench one's thirst, carbuncle furuncle;External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For mesh Red, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tying mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting. For incoordination between the liver and stomach, vomit acid regurgitation.
Radix seu Herba Gei aleppici [source] Rosaceae avens south Fructus Adinae, is used as medicine with herb or root.[nature and flavor] are pungent, bitter, flat. [function cures mainly] eases pain, blood pressure lowering, regulating menstruation, expelling wind and removing dampness.For hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, Infantile convulsion, lumbago, skelalgia of rheumatism;Carbuncle furuncle and phyma poison, traumatic injury are controlled in external.
Rhizoma Zingiberis [source] this product is the dry rhizome of zingiber.[nature and flavor] are pungent, hot.[return through] return spleen, stomach, kidney, the heart, Lung meridian.[function cures mainly] Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG promotes blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, cold extremities faint pulse, Phlegm retention is breathed with cough.
Tronae [source] is that the alkaline earth of containing sodium carbonate boils and forms or naturally generate in salt water lakeside.[nature and flavor] salty in the mouth, twenty, Hardship, property is put down.[function cures mainly] is dispelled Ba Dagan, is helped digestion, relieving constipation, only corruption, removing toxic substances.Curing mainly dyspepsia, stomach Ba Da does disease, just Secret, women's mass formed by blood stasis, amenorrhea, placenta retention, skin infection.
Radix Codonopsis [source] this product is the dry root of Campanulaceae Radix Codonopsis.[nature and flavor] are sweet, flat.[return through] returns spleen, lung Warp.[function cures mainly] invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat Quench one's thirst.
Cortex Magnoliae Officinalis [source] Magnoliacea plant Cortex Magnoliae Officinalis or the dry dried bark of magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin.[function cures mainly] is dry Wet expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Radix Bupleuri [source] umbelliferae bupleurum or the dry root of Radix Bupeuri Scorzonerfolii..[function cures mainly] reconciling superficies and interior, soothing the liver, rise Sun.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official prolapses, proctoptosis.
Herba Lysimachiae [source] this product is the dry herb of Ofthe Primulaceae Lysimachia christinae Hance.[nature and flavor] are sweet, salty, are slightly cold.[return Warp] return liver, gallbladder, kidney, bladder warp.[function cures mainly] eliminating damp-heat, treating stranguria, detumescence.For pyretic stranguria, Sha Lin, urinate and puckery have a pain, yellow Subcutaneous ulcer dark coloured urine, carbuncle furuncle, venom;Liver and bile stone, lithangiuria.
Radix Salviae Miltiorrhizae [source] this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.[nature and flavor] are bitter, are slightly cold.[return through] GUIXIN, Liver Channel.[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen amasss Poly-, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia;Hepatosplenomegaly, angina pectoris.
Fructus Aurantii Immaturus [source] this product is the dry young fruit of rutaceae Citrus aurantium Linn..[nature and flavor] are bitter, pungent, sour, temperature.[return through] Return spleen, stomach warp.[function cures mainly] dispelling the stagnated QI removing food stagnancy, scattered painful abdominal mass of reducing phlegm.Stopping in stagnant, feeling of fullness distending pain, weight after dysentery, stool is not Logical, the expectorant stagnant vapour lock thoracic obstruction, blocked-up chest;Gastroptosis, proctoptosis, uterine prolapse.
Moon laural cherry [source] is the fruit of barrier section plant Laurel.[nature and flavor] two grades are xeothermic, acrid in the mouth.[effect] cold removing Antiinflammatory, strengthens audition, calculus dissolving and excreting, removing toxic substances etc.;Control cold inflammation to swell, auditory dysesthesia, various calculus, various poisonings etc..Cure mainly wet Cold or lymphatic temperament disease, such as cold arthralgia, Minor articulus pain, sciatica, cough, asthma, urine retention, the enuresis, warp Close, moist paralysis, facial paralysis, tremor and white macula, freckle etc..
The Rhizoma Atractylodis Macrocephalae [source] this product is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.[nature and flavor] are bitter, sweet, temperature.[return through] return spleen, Stomach warp.[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, water Swollen, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Fructus Aurantii [source] this product is the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof.[nature and flavor] Bitter, pungent, sour, temperature.[return through] returns spleen, stomach warp.[function cures mainly] regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Coercing the stagnation of QI for breast, distension aches Bitterly, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention;Gastroptosis, proctoptosis, sub-official prolapses.
Rhizoma Sparganii [source] this product is the dry tuber of Sparganiaceae plant rhizoma scirpi.[nature and flavor] are pungent, bitter, flat.[return through] Return liver, spleen channel.[function cures mainly] removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.
Gomuti fibre [source] is the root of Zong Tong section plant gomuti fibre.[nature and flavor] taste is micro-sweet, puckery.Gas is fragrant.Property flat.[function cures mainly] adjusts Mend four towers, lactogenic, Qinghuo Jiedu, promoting the function of the gallbladder to alleviate jaundice.Curing mainly chills and pain of the waist and kness, the most weak, libido is cold, sexual impotence, seminal emission, premature ejaculation, Lack of lactation after delivery, hypogalactia, jaundice.
Wild Fructus Kaki [source] is root, branch and the leaf of Ebenaceae plant open country Fructus Kaki.[nature and flavor] bitter in the mouth, puckery, gas is fragrant.Cold in nature.[function master Control] nurse one's health four towers, mend soil stomach invigorating, Qinghuo Jiedu.Curing mainly weak, anorexia, weak and sickly, drought declines, jaundice, burn due to hot liquid or fire.
Herba brassicae narinosae [source] is the herb of crucifer broadbeaked mustard.[nature and flavor] are sweet, flat, nontoxic.[function cures mainly] laxation, Soothing the liver, profit the five internal organs.
Heterolamium debile [source] medical material Ji Yuan: for the herb of the different inner Semen Sesami of labiate.[nature and flavor] acrid in the mouth;Bitter;Property Cool.[function cures mainly] regulating qi-flowing for harmonizing stomach;Heat-clearing and toxic substances removing.Main gastropyretic vomiting;Skin ulcer swells;The puckery pain of pyretic stranguria;Menoxenia.
Fructus Liquidambaris [source] this product is the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum.[nature and flavor] are bitter, flat.[return Warp] return liver, kidney channel.[function cures mainly] dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, breast Few amenorrhea.
Semen pegani harmalae [source] is the seed of zygophyllaceae plant Herba pegani harmalae.[nature and flavor] are bitter, temperature.[function cures mainly] controls cough, Dysuria, numb limbs and tense tendons, joint aches.
Herba Saussureae amarae [source] Compositae Genus Saussurea plant donkey ear hieracioides, with all herbal medicine.[nature and flavor] are bitter, cold.[function Cure mainly] heat-clearing and toxic substances removing, detumescence.Lymphoid tuberculosis, parotitis, furuncle and phyma are controlled in external.
Between gold, green bamboo [source] is the stem of green bamboo between grass gold.[nature and flavor] mildly bitter flavor, sweet, warm in nature.[function Cure mainly] Qinghuo Jiedu, promoting the function of the gallbladder to alleviate jaundice.Cure mainly jaundice, dizziness, the urine puckery pain of heat.
Black Mulberry [source] is black or the erythrocarpus of the black Mulberry of moraceae plants.[nature and flavor] sour in the mouth is micro-sweet.[function cures mainly] adjusts Joint abnormal blood matter and bile matter, the pharyngolaryngitis that disappears swells, stops hot body fluid to flee in upper respiratory tract, and quench the thirst increasing food, except infections heals Skin ulcer, clearing away heat to stop diarrhea.Cure mainly hot or blood matter and bile matter disease, as pharyngolaryngitis swells, thirsty poor appetite, oral ulcer, intestinal Road skin ulcer wound, hot diarrhoea and dysentery.
Peel of Fructus Chebulae [source] is that the maturation of Combretum Racemosum plant Fructus Chebulae is dried outer peel and mesocarp.[nature and flavor] one-level is done Cold, mildly bitter flavor.[function cures mainly] is raw does raw trembling with fear, and removes abnormal bile matter and dysregulation blood matter, heat clearing away supplementing the brain, benefit stomach, increases Hypermnesia is recalled, and improves vision, and the evanescence of heat that disappears is strongly fragrant, dampness nourishing muscle and tendon, removing heat from blood black hair.Cure mainly hot and gallbladder matter or blood matter disease, as Hot brain is empty, insufficiency of stomach, hypomnesis, and vision reduces, hot depression, moist facial paralysis, heat in blood poliosis.
Resina Populi Diversifoliae [source] is that material for many years retained in soil by Salicaceous Plants Populus euphratica resin.[nature and flavor] three grades are dry Heat, salty in the mouth.[function cures mainly] raw dry heat, cold relieving helps digestion, and dissipates gas pain relieving, and warm-up tonifying YANG, preventing phlegm from forming and stopping coughing, dampness blazes.Cure mainly Raw property or lymphatic temperament disease, such as cold syndrome of the stomach food stagnation, intestinal stricture of vagina stomachache, coldness of the body sun disease, abundant expectoration cough, eczema sudorale, vitiligo etc..
The present invention compared with prior art, has the advantages that
1, the selected medicament composing prescription of the present invention, its drug component through dialectical compatibility, complements each other using, has synergism, Play altogether gallbladder stomach rule together, effect of depressed liver-energy dispersing and QI regulating, strengthening the body resistance, the treatment to bile reflux gastritis reaches treating both the principal and the secondary aspects of a disease at the same time.Prescription Being particular about monarch, four natures and five flavors of drug lifting, the 8 taste Chinese crude drugs such as wild Fructus Kaki, gomuti fibre, Herba brassicae narinosae, Heterolamium debile, Fructus Liquidambaris are monarch altogether Medicine, plays a leading role in compound recipe, treats disease by acting on major target class;Fructus Aurantii, Tronae etc. 7 taste medical material be ministerial drug, Strengthen the pharmacological action of monarch drug by acting on the target spot identical with monarch drug, thus reduce monarch drug required dosage;Remaining for assistant, Make medical herbs, to improve the bioavailability of monarch, ministerial drug, coordinate the activity of their each composition.In we, wild Fructus Kaki is cold in nature, gomuti fibre property Put down, Cassia siamea leaf hardship is cool, Rhizoma Zingiberis is hot, four and use, the void of weight tonifying the spleen and stomach.Semen pegani harmalae and Fructus Aurantii, Tronae phase 5, can be notable Strengthen gastral digestive function and digestive tract power.Herba Portulacae and Herba Saussureae amarae phase 5, toxic dampness and heat of can dispelling.Month sub-cold removing of laural cherry Antiinflammatory, tragacanth corrects its evil, Heterolamium debile regulating qi-flowing for harmonizing stomach, and three mutually 5 can remarkably promote the absorption of local inflammation and stomach sticks The reparation of film.Especially it is noted that after the Herba brassicae narinosae that is especially added with of the present invention and Herba Saussureae amarae compatibility, act on body not Same target spot, synergism can produce the special effect improving human immunologic function, can effectively regulate each function of body, improves Body resists the ability of external toxin puzzlement, effectively prevents old complaint from recurring.
2, the present invention is directed to bile reflux gastritis pathogeny, launch treatment from Mutiple Targets, too many levels, multipath, Clinical practice has rapid-action, determined curative effect, patient compliance are good, safe without toxic side effect, can significantly improve patient self Immunity, treating both the principal and secondary aspects of a disease prevents recurrence, thus has wide potential applicability in clinical practice.
Detailed description of the invention
In order to be more fully understood that and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Weigh: 7 grams of Cassia siamea leaf, wild Fructus Kaki 15 grams, Herba brassicae narinosae 16 grams, tragacanth 6 grams, Herba Portulacae 9 grams, Rhizoma Coptidis 8 grams, Radix seu Herba Gei aleppici 10 Gram, Rhizoma Zingiberis 12 grams, Radix Codonopsis 5 grams, Cortex Magnoliae Officinalis 8 grams, Radix Bupleuri 12 grams, Herba Lysimachiae 10 grams, Radix Salviae Miltiorrhizae 5 grams, Fructus Aurantii Immaturus 12 gram, month laural cherry son 5 grams, The Rhizoma Atractylodis Macrocephalae 5 grams, Fructus Aurantii 5 grams, Rhizoma Sparganii 6 grams, Tronae 12 grams, Heterolamium debile 14 grams, gomuti fibre 10 grams, Fructus Liquidambaris 13 grams, Semen pegani harmalae 5 Gram, Herba Saussureae amarae 4 grams.
Preparation method is: above-mentioned pulverizing medicinal materials in addition to Tronae, tragacanth is become coarse powder;Decoct twice, for the first time Decoction adds water 8 times amount, soaks 2h, decocts 3h, filters;Second time decocts 6 times amount that add water, and decocts 2h, filters;Merge twice to decoct Liquid mix homogeneously with Tronae, tragacanth again after subpackage.
Usage and dosage: oral, every day 2 times, the most each 1 time, each 100ml;Within 15 days, it is 1 course for the treatment of, takes 2 treatments continuously Journey.
Clinical data:
1, case selection:
Selecting the patients with bile reflux gastritis 40 example clinical observation in my institute's diagnosis and treatment, clinical symptoms all meets bile reflux stomach Scorching diagnosis and treatment standard.Patient is randomly divided into treatment group and matched group two groups, treatment group 20 example, matched group 20 example.Treatment group and comparison Organize the course of disease of two groups of cases, degrees of symptoms basically identical, without significant difference, there is comparability.
2, medicament selection:
Treatment group takes the Chinese medicine decoction obtained by the embodiment of the present invention 1, oral, every day 2 times, the most each 1 time, each 100ml; It within 15 days, it is 1 course for the treatment of.
Matched group oral mycin, bismuth pectin, amoxicillin and motilium.The course for the treatment of is with treatment group.
2 courses for the treatment of are treated in smelting continuously, contrast two groups of curative effects.
3, efficacy determination:
(1) curing: gastroscopy inflammation disappears, gastric mucosa tissue recovers normal, and bile reflux phenomenon is wholly absent.
(2) take a turn for the better: gastroscopy inflammation has clear improvement, and gastric mucosa tissue tends to normal, the slightest bile reflux Phenomenon.
(3) not healing: gastroscopy inflammation is without any improvement, gastric mucosa tissue is abnormal, has serious bile reflux phenomenon.
4, result:
Selecting in the treatment group of the embodiment of the present invention 1 Chinese medicine decoction, cure 14 examples, take a turn for the better 5 examples, the most 1 example, cure rate 70%, always Effective percentage 95%.Average cure time 20.5 days.Healing and improvement patient are followed the tracks of and follows up a case by regular visits to 24 months, without 1 example recurrence.
Curing 8 examples in matched group, take a turn for the better 8 examples, the most 4 examples, cure rate 40%, total effective rate 80%.Average cure time 28 My god.Healing and improvement patient are followed the tracks of and follows up a case by regular visits to 24 months, 2 examples recurrences.
Result above shows, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Embodiment 2
Weigh: Herba brassicae narinosae 16 grams, tragacanth 6 grams, Herba Portulacae 9 grams, Rhizoma Coptidis 8 grams, Radix seu Herba Gei aleppici 10 grams, Rhizoma Zingiberis 12 grams, Radix Codonopsis 5 grams, Cortex Magnoliae Officinalis 8 grams, Radix Bupleuri 12 grams, Herba Lysimachiae 10 grams, Radix Salviae Miltiorrhizae 5 grams, Fructus Aurantii Immaturus 12 gram, month laural cherry 5 grams, the Rhizoma Atractylodis Macrocephalae 5 grams, Fructus Aurantii 5 grams, Rhizoma Sparganii 6 grams, Tronae 12 grams, Heterolamium debile 14 grams, gomuti fibre 10 grams, Fructus Liquidambaris 13 grams, Semen pegani harmalae 5 grams, Herba Saussureae amarae 4 grams.Preparation side Method is with embodiment 1.
In 10 patients with bile reflux gastritis of the Chinese medicine decoction that the selection embodiment of the present invention 2 is made, cure 5 examples, good Turn 3 examples, the most 2 examples, cure rate 50%, total effective rate 80%.Healing and improvement patient are followed the tracks of and follows up a case by regular visits to 24 months, 1 example recurrence.
Embodiment 3
Weigh: 7 grams of Cassia siamea leaf, wild Fructus Kaki 15 grams, Herba brassicae narinosae 16 grams, tragacanth 6 grams, Herba Portulacae 9 grams, Rhizoma Coptidis 8 grams, Radix seu Herba Gei aleppici 10 Gram, Rhizoma Zingiberis 12 grams, Radix Codonopsis 5 grams, Cortex Magnoliae Officinalis 8 grams, Radix Bupleuri 12 grams, Herba Lysimachiae 10 grams, Radix Salviae Miltiorrhizae 5 gram, month laural cherry son 5 grams, the Rhizoma Atractylodis Macrocephalae 5 grams, Fructus Aurantii 5 grams, Rhizoma Sparganii 6 grams, Heterolamium debile 14 grams, gomuti fibre 10 grams, Fructus Liquidambaris 13 grams, Herba Saussureae amarae 4 grams.The same embodiment of preparation method 1。
In 12 patients with bile reflux gastritis of the Chinese medicine decoction that the selection embodiment of the present invention 3 is made, cure 6 examples, good Turn 2 examples, the most 2 examples, cure rate 60%, total effective rate 80%.Healing and improvement patient are followed the tracks of and follows up a case by regular visits to 24 months, 2 examples recurrences.
Embodiment 4
Weigh: 7 grams of Cassia siamea leaf, wild Fructus Kaki 15 grams, Herba brassicae narinosae 16 grams, tragacanth 6 grams, Herba Portulacae 9 grams, Rhizoma Coptidis 8 grams, Radix seu Herba Gei aleppici 10 Gram, Rhizoma Zingiberis 12 grams, Radix Codonopsis 5 grams, Cortex Magnoliae Officinalis 8 grams, Radix Bupleuri 12 grams, Herba Lysimachiae 10 grams, Radix Salviae Miltiorrhizae 5 grams, Fructus Aurantii Immaturus 12 gram, month laural cherry son 5 grams, 5 grams of green bamboo, Rhizoma Sparganii 6 grams, Tronae 12 grams, Heterolamium debile 14 grams, gomuti fibre 10 grams, Fructus Liquidambaris 13 grams, camel between the Rhizoma Atractylodis Macrocephalae 5 grams, gold Fluffy sub 5 grams, Herba Saussureae amarae 4 grams.Preparation method is with embodiment 1.
Embodiment 5
Weigh: 7 grams of Cassia siamea leaf, wild Fructus Kaki 15 grams, Herba brassicae narinosae 16 grams, tragacanth 6 grams, Herba Portulacae 9 grams, 8 grams of black Mulberry, Radix seu Herba Gei aleppici 10 Gram, Rhizoma Zingiberis 12 grams, Radix Codonopsis 5 grams, Cortex Magnoliae Officinalis 8 grams, Radix Bupleuri 12 grams, Herba Lysimachiae 10 grams, Radix Salviae Miltiorrhizae 5 grams, Fructus Aurantii Immaturus 12 gram, month laural cherry son 5 grams, The Rhizoma Atractylodis Macrocephalae 5 grams, Fructus Aurantii 5 grams, Rhizoma Sparganii 6 grams, Tronae 12 grams, Heterolamium debile 14 grams, gomuti fibre 10 grams, Fructus Liquidambaris 13 grams, Semen pegani harmalae 5 Gram, Herba Saussureae amarae 4 grams.Preparation method is with embodiment 1.
Embodiment 6
Weigh: 7 grams of Cassia siamea leaf, wild Fructus Kaki 15 grams, Herba brassicae narinosae 16 grams, tragacanth 6 grams, Herba Portulacae 9 grams, Rhizoma Coptidis 8 grams, Radix seu Herba Gei aleppici 10 Gram, Rhizoma Zingiberis 12 grams, Radix Codonopsis 5 grams, Cortex Magnoliae Officinalis 8 grams, Radix Bupleuri 12 grams, Herba Lysimachiae 10 grams, Radix Salviae Miltiorrhizae 5 grams, black Mulberry 12 gram, month laural cherry son 5 grams, The Rhizoma Atractylodis Macrocephalae 5 grams, peel of Fructus Chebulae 5 grams, Rhizoma Sparganii 6 grams, Tronae 12 grams, Heterolamium debile 14 grams, gomuti fibre 10 grams, Fructus Liquidambaris 13 grams, Herba pegani harmalae Son 5 grams, Herba Saussureae amarae 4 grams.Preparation method is with embodiment 1.
Embodiment 7
Weigh: peel of Fructus Chebulae 7 grams, wild Fructus Kaki 15 grams, Herba brassicae narinosae 16 grams, tragacanth 6 grams, Herba Portulacae 9 grams, Rhizoma Coptidis 8 grams, Radix seu Herba Gei aleppici 10 Gram, Rhizoma Zingiberis 12 grams, Radix Codonopsis 5 grams, Cortex Magnoliae Officinalis 8 grams, Radix Bupleuri 12 grams, Herba Lysimachiae 10 grams, Radix Salviae Miltiorrhizae 5 grams, Fructus Aurantii Immaturus 12 gram, month laural cherry son 5 grams, The Rhizoma Atractylodis Macrocephalae 5 grams, Resina Populi Diversifoliae 5 grams, Rhizoma Sparganii 6 grams, Tronae 12 grams, Heterolamium debile 14 grams, gomuti fibre 10 grams, Fructus Liquidambaris 13 grams, Semen pegani harmalae 5 Gram, Herba Saussureae amarae 4 grams.Preparation method is with embodiment 1.
Embodiment 8
Weigh: 7 grams of Cassia siamea leaf, wild Fructus Kaki 15 grams, Herba brassicae narinosae 16 grams, tragacanth 6 grams, Herba Portulacae 9 grams, Rhizoma Coptidis 8 grams, Radix seu Herba Gei aleppici 10 Gram, Rhizoma Zingiberis 12 grams, Radix Codonopsis 5 grams, Cortex Magnoliae Officinalis 8 grams, Radix Bupleuri 12 grams, Herba Lysimachiae 10 grams, Radix Salviae Miltiorrhizae 5 grams, Fructus Aurantii Immaturus 12 gram, month laural cherry son 5 grams, The Rhizoma Atractylodis Macrocephalae 5 grams, Fructus Aurantii 5 grams, peel of Fructus Chebulae 6 grams, Resina Populi Diversifoliae 6 grams, Tronae 12 grams, Heterolamium debile 14 grams, gomuti fibre 10 grams, Fructus Liquidambaris 13 Gram, Semen pegani harmalae 5 grams, Herba Saussureae amarae 4 grams.Preparation method is with embodiment 1.
Selecting the patients with bile reflux gastritis patient 20 example clinical observation in my institute's diagnosis and treatment, clinical symptoms all meets bile Reflux gastritis diagnosis and treatment standard.Patient is randomly divided into 5 groups, takes the Chinese medicine decoction that embodiment of the present invention 4-8 is made, mouth respectively Clothes, every day 2 times, the most each 1 time, each 100ml, record curative effect is as follows:
Case Cure Take a turn for the better Do not heal Untoward reaction Recur in 2 years Average cure time
Embodiment 4 4 3 1 0 0 1 29 days
Embodiment 5 4 3 1 0 0 1 28 days
Embodiment 6 4 4 0 0 0 0 24 days
Embodiment 7 4 4 0 0 0 0 21 days
Embodiment 8 4 4 0 0 0 0 18 days
Obviously, the above embodiment of the present invention is only for clearly demonstrating example of the present invention, and is not to this The restriction of bright embodiment, the such as present invention, in addition to making decoction agent, can also be used with common technology and make other peroral dosage forms.Phase Close Chinese medicine and pharmacology thereof all can be obtained by existing open source literature and network, it is also possible to the medical material by close effect is the most alternative. For those of ordinary skill in the field, the change of other multi-form can also be made on the basis of the above description Or variation.Here cannot all of embodiment be given exhaustive.Every belong to that technical scheme extended out aobvious And the change being clear to or variation are still in the row of protection scope of the present invention.

Claims (3)

1. the Chinese medicine decoction being used for treating bile reflux gastritis, it is characterised in that by the Chinese crude drug of following weight proportion It is prepared from: 7 parts of Cassia siamea leaf, wild Fructus Kaki 15 parts, Herba brassicae narinosae 16 parts, tragacanth 6 parts, Herba Portulacae 9 parts, Rhizoma Coptidis 8 parts, Radix seu Herba Gei aleppici 10 Part, Rhizoma Zingiberis 12 parts, Radix Codonopsis 5 parts, Cortex Magnoliae Officinalis 8 parts, Radix Bupleuri 12 parts, Herba Lysimachiae 10 parts, Radix Salviae Miltiorrhizae 5 parts, Fructus Aurantii Immaturus 12 part, month laural cherry son 5 parts, The Rhizoma Atractylodis Macrocephalae 5 parts, Fructus Aurantii 5 parts, Rhizoma Sparganii 6 parts, Tronae 12 parts, Heterolamium debile 14 parts, gomuti fibre 10 parts, Fructus Liquidambaris 13 parts, Semen pegani harmalae 5 Part, Herba Saussureae amarae 4 parts.
The preparation method of a kind of Chinese medicine decoction for treating bile reflux gastritis the most according to claim 1, it is special Levy and be, above-mentioned pulverizing medicinal materials in addition to Tronae, tragacanth is become coarse powder;Decoct twice, decoct for the first time and add water 8 times Amount, soaks 2h, decocts 3h, filters;Second time decocts 6 times amount that add water, and decocts 2h, filters;Merge twice decocting liquid again with Tronae, Subpackage after tragacanth mix homogeneously.
The Chinese medicine decoction the most according to claim 1 purposes in preparation treatment or prevention bile reflux gastritis medicine.
CN201610787802.0A 2016-08-31 2016-08-31 A kind of Chinese medicine decoction for treating bile reflux gastritis Pending CN106215163A (en)

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Application publication date: 20161214