CN106214500A - A kind of gel containing Cer NS & carnosine submicron liposome and preparation method thereof - Google Patents
A kind of gel containing Cer NS & carnosine submicron liposome and preparation method thereof Download PDFInfo
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- CN106214500A CN106214500A CN201610710922.0A CN201610710922A CN106214500A CN 106214500 A CN106214500 A CN 106214500A CN 201610710922 A CN201610710922 A CN 201610710922A CN 106214500 A CN106214500 A CN 106214500A
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- carnosine
- cer
- gel
- submicron liposome
- liposome
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
Abstract
The present invention relates to the technical field of carrier system in cosmetics technology of preparing, more particularly to a kind of gel containing Cer NS & carnosine submicron liposome and preparation method thereof.A kind of gel containing Cer NS & carnosine submicron liposome, containing described Cer NS & carnosine submicron liposome in this gel, described Cer NS & carnosine submicron liposome is made up of active component Cer NS, carnosine and lipid, emulsifying agent, co-emulsifier, stabilizer, preservative and water, in light yellow translucent outward appearance.Gel containing Cer NS & carnosine submicron liposome of the present invention, has obvious anti-oxidation efficacy with having and significantly improves wrinkle volume and the degree of depth, improve the anti-aging effects of skin surface texture skin.
Description
Technical field
The present invention relates to the technical field of carrier system in cosmetics technology of preparing, contain more particularly to one
Gel of Cer NS & carnosine submicron liposome and preparation method thereof.
Background technology
Ceramide also known as sphingolipid, is the work that is made up of sphingosine long chain base and a fatty acid of a class
Property composition, plays an important role in skin protection and hair care art.Research shows, ceramide plays firm screen at skin surface
Barrier effect, prevents moisture from distributing and to outside stimulation, moist, moisturizing skin.When dry, desquamation, cracking phenomena occurs in skin,
When its barrier function substantially reduces, skin supplements ceramide can recover rapidly moisturizing and barrier function.And different nerve sheath
Ammonia alcohol base can combine again with fatty acid and form different ceramides.As a member therein, Cer NS is except having
Help skin pins moisture, promotes outside skin barrier self-regeneration and regulation and control Skin Cell effect, moreover it is possible to suppression skin enlivens
Smegma, makes skin water and oil balance, strengthens the self-protection function of skin.Thus cosmetic field is had by Cer NS
There is important both effectiveness value.
Carnosine, by a kind of dipeptide structure being made up of Beta-alanine and L-Histidine, has activity of fighting against senium.At cosmetics
In, the activity of fighting against senium mechanism of carnosine is mainly passed through: delay the shortening of telomere；Stop oxidative damage, itself be that activity is free
Base (ROS) quencher, is again a kind of heavy metal chelant；Suppression glycosylation, carbonyl radical (RCS) quencher, also may be used
Cancellation glycosylation end (AGE) product；Stop macromolecules cross-linking, such as collagen protein；Suppression MMP-1, protection Skin Cell from
The damage of UVB.But, as a kind of water miscible dipeptides, its transdermal capability is poor, therefore in the application of anti-aging cosmetics
It is restricted.
Nano-carrier technology is that cosmetic industry provides the newest thinking of development.Such as, will have the highest physiology phase
The matrix material of capacitive is as carrier, and becoming Nano grade by advanced nanotechnology can the carrier system of carrying active substance
System.Wherein, solid lipid nanoparticle (Solid Lipid Nanoparticles) is to grow up early 1990s,
Using the degradable naturally occurring or synthetic lipoids material of organism as carrier, by Drug absorbability, wrap up or clamp in lipid film
The particle diameter made is about the submicron transport system of new generation of 10-1000 nm, also referred to as submicron liposome.Utilize this carrier
Technology is possible not only to improve active substance dissolubility in water and stability, improves its compatibility in formula, moreover it is possible to
Improve slow-releasing and the bioavailability of active substance, strengthen its effect performance in cosmetics.Therefore, wrapped up by carrier
It is possible not only to weaken even solution Cer NS these shortcomings in application process, the most significantly expands its range of application.Simultaneously
Also make Cer NS and carnosine compound to be possibly realized.
Summary of the invention
For improving Cer NS technical problem in application, and the problem that carnosine transdermal rate is low, the present invention's
First purpose provides a kind of gel containing Cer NS & carnosine submicron liposome, its objective is in Cosmetic Manufacture
In easy to use, simultaneously can more preferable effect of performance defying age anti-wrinkle in cosmetics.Second object of the present invention is
The preparation method of above-mentioned submicron liposome is provided.
For reaching above-mentioned first purpose, technical scheme is as follows:
A kind of gel containing Cer NS & carnosine submicron liposome, containing described Cer NS & carnosine in this gel
Submicron liposome, Cer NS & carnosine submicron liposome described by mass percentage is made up of following component:
Cer NS 1%-5%,
Carnosine 1%-8%,
Lipid 15%-35%,
Emulsifying agent 10%-30%,
Co-emulsifier 1%-4%,
Stabilizer 0.2%-1.5%,
Preservative 0.2～1.5%,
Remaining is water.
As preferably, Cer NS & carnosine submicron liposome described by mass percentage is by following component
Constitute:
Cer NS 2%-4%,
Carnosine 2%-7%
Lipid 20%-30%,
Emulsifying agent 15%-25%,
Co-emulsifier 2%-3%,
Stabilizer 0.5%-1.2%,
Preservative 0.5～1.2%,
Remaining is water.
As improving further, the mean diameter of the Cer NS & carnosine submicron liposome of the present invention is 50 ~
200nm。
As preferably, described lipid is selected from one or more combinations following: caprylic/capric triglyceride, glycerol acetic acid
Ester, glyceryl stearate, butyl capryl alcohol salicylate, glycerin polyether-26, octyl dodecanol.
As preferably, described emulsifying agent is selected from the combination of one or more of: PEG-8 caprylic/capric glyceride type,
Stereth-21, ceteth-25, PPG-4-ceteth-20, PEG-30 dimerization hydroxy stearic acid ester, PEG-
40 castor oil hydrogenated, polyglycerolpolyrici.oleate, Pyrusussuriensis smooth olive oil acid esters, the smooth oleate of Pyrusussuriensis, the smooth laurate of Pyrusussuriensis,
Sorbitan sesquioleate, Polyoxyethylene Sorbitan Monooleate, polysorbate-60, polysorbate-40, Coco-Glucoside/cocos nucifera oil
Alcohol, behenyl alcohol and Natrulon H-10 five stearate and stearoyl dilactic acid sodium mixture.
As preferably, described co-emulsifier is selected from the combination of one or more of: olive oil PEG-7 esters, poly-sweet
Oil-3 diisopstearates, ceteth-6.
As preferably, described stabilizer is selected from the combination of one or more of: butanediol, dipropylene glycol, spermol, fourth
Hydroxy toluene.
As preferably, described preservative is selected from the combination of one or more of: phenoxyethanol, Sensiva SC50, Buddhist nun
Pool tortoise beetle ester, propylparaben.
For reaching above-mentioned second purpose, technical scheme is as follows:
A kind of method of the submicron liposome prepared described in any one technical scheme above-mentioned, the method comprises the following steps:
Step (1): using lipid, emulsifying agent, co-emulsifier and stabilizer as oil phase, under the conditions of 60～80 DEG C, mixing is all,
100～300 rpm stirring 10～25 min form uniform mixed solution；
Step (2): the mixed liquor in step (1) adds Cer NS and continues stirring, and mixing time is about 5～15
Min, makes Cer NS be completely dissolved；
Step (3): adding room temperature and the aqueous phase dissolved with carnosine in the mixed solution of step (2), 100～200 rpm constant speed are stirred
Mix 5～10 min；
Step (4): be cooled to by step (3) gained mixed liquor less than 45 DEG C, addition 0.5～the preservative of 1.0%, cooling obtains
Light yellow translucent Cer NS & carnosine submicron liposome；
Step (5): the Cer NS & carnosine submicron liposome of preparation is joined the mixing of the other materials mixing of gel
Thing uniformly mixes, it is thus achieved that containing the gel of Cer NS & carnosine submicron liposome.
As preferably, the other materials of described gel includes wetting agent, skin moistening oils and fats, surfactant, thickening agent, skin
One or more mixing in skin conditioner, antiinflammatory, deionized water.
By technique scheme, a kind of gel containing Cer NS & carnosine submicron liposome that the present invention provides
And preparation method thereof, it has the beneficial effects that: liposome possesses the feature that stability is high, water dispersible is good, bio-compatibility is good,
Can interworking any with gel formula, and preparation method is the most controlled, reproducible.The more important thing is, containing Cer NS & flesh
The gel of peptide submicron liposome has skin moisturizing, anti-oxidation efficacy and has and significantly improve wrinkle volume and the degree of depth, changes
The anti-aging effects of kind skin surface texture.
Accompanying drawing explanation
The variation diagram of Fig. 1 wrinkle volume, wherein: * * represents difference highly significant (P < 0.01).
Fig. 2 maximum wrinkle depth variation diagram.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme is clearly and completely described.
Embodiment 1
Weigh 5g caprylic/capric triglyceride, 18g octyl dodecanol, 2g tristerin, 2g olive oil PEG-7 esters,
5g polysorbate-60, the smooth laurate of 3g Pyrusussuriensis, 15g PEG-30 dimerization hydroxy stearic acid ester and 5g butanediol, in 65
DEG C, under the conditions of 200 rpm stirring form homogeneous solution；It is subsequently added 2g Cer NS, continues stir about 10 min, add molten
There are the aqueous solution of 2g carnosine, 250 rpm to stir 8 min, suitably add 0.5g phenoxyethanol after cooling, continue stirring 5min, cold
But solid state gelatineous Cer NS & carnosine submicron liposome is obtained.Measure its particle diameter through laser particle analyzer and be about 103 nm.
Embodiment 2
Weigh 5g tristerin, 5g butyl capryl alcohol salicylate, 22g octyl dodecanol, 5g ceteth-25,5g mountain
Pears smooth olive oil acid esters, 5g Polyoxyethylene Sorbitan Monooleate, 10g PEG-30 dimerization hydroxy stearic acid ester, 4g dipropylene glycol and 2g gather sweet
Oil-3 diisopstearates, stir into homogeneous solution under the conditions of 70 DEG C, add 1.5g Cer NS, and mixing speed is 300
Rpm, mixing time is 8 min；Adding the 3g carnosine and 32g water dissolved in advance, 200 rpm stir 10 min, suitably cool down
Rear addition 0.5g phenoxyethanol and Sensiva SC50 mixture.Natural cooling obtains micro white Cer NS & carnosine sub-micro
Mizhi plasmid solid.Measure its particle diameter through laser particle analyzer and be about 125 nm.
Embodiment 3
Weigh 3g caprylic/capric triglyceride, 2 g glyceryl monostearates, 2g butyl capryl alcohol salicylate, 23g octyl group 12
Alcohol, 8g stereth-21,5g PEG-30 dimerization hydroxy stearic acid ester, 2g Coco-Glucoside/cocoanut oil alcohol, 7g behenyl alcohol/
Natrulon H-10 five stearates/stearoyl dilactic acid sodium mixture, 3g butanediol, 3g Polyoxyethylene Sorbitan Monooleate and 2g Pyrusussuriensis
Smooth oleate, under the conditions of 80 DEG C, stirring forms homogeneous mixture solotion, adds 2g Cer NS, and mixing speed is 300 rpm,
Mixing time is 5 min；It is subsequently added and is pre-dissolved 34g deionized water, 3g carnosine and 0.5g methyl hydroxybenzoate, 200 rpm completely
Stirring 8 min, suitably add 0.5g phenoxyethanol after cooling, natural cooling obtains Cer NS & carnosine submicron liposome.
This Cer NS & carnosine submicron liposome solid measures its particle diameter through laser particle analyzer and is about 89 nm.
Embodiment 4
The Cer NS & carnosine submicron liposome utilizing the present invention to prepare prepares cosmetic gel, and its step is as follows: enchashment
Having gel formula 89.4g to mix, add 10g Cer NS & carnosine submicron liposome (from embodiment 1), 300rpm stirs
Mix 15 minutes, be uniformly dispersed；200rpm stirring is cooled to 40 ~ 45 DEG C, adds 0.6g preservative, continues stirring and is cooled to not higher than
38 DEG C, stop stirring, obtain 100g and contain the gel of Cer NS & carnosine submicron liposome.
Embodiment 5
The Cer NS & carnosine submicron liposome utilizing the present invention to prepare prepares gel, and its step is as follows: enchashment has gel
Formula 79.4g mixes, and 20g Cer NS & carnosine submicron liposome (from embodiment 3) is heated to 60 ~ 65 DEG C,
300rpm stirs 10 minutes, is uniformly dispersed；200rpm stirring is cooled to 40 ~ 45 DEG C, adds 0.6g preservative, continues stirring cooling
To not higher than 38 DEG C, stop stirring, obtain 100g and contain the gel of Cer NS & carnosine submicron liposome.
Embodiment 6
The frost provided in this experimental selection embodiment 4 carries out clinical experiment.
This experiment includes 20 volunteers, female age in 22-55 one full year of life, the face canthus person that has wrinkle.During testing
Use according to regulations tested material and all information.Every day, twice left and right face was smeared at random containing Cer NS & carnosine sub-micro sooner or later
The gel of Mizhi plasmid and the gel without Cer NS & carnosine submicron liposome, smear for test group, otherwise be right
According to group.Test period is 6 weeks.In W0(use before), W2 (using 2 weeks), W4(use 4 weeks) and W6(use 6 weeks) pass through
Primoslite 18*13 obtains canthus wrinkle view data, and by the volume of software analysis canthus wrinkle and change in depth, and
Its diversity is checked with t inspection.Calculating rate of change %, formula is as follows simultaneously:
Rate of change %=(WN-W0)/W0*100, wherein WN refers to use the numerical value in N week, W0 to refer to the numerical value before using.
1. wrinkle bulking value rate of change
It will be noted from fig. 1 that test group and matched group have declined at W2, W4, but test group fall be all better than right
According to group, matched group is follow-up simultaneously all bounce-back, and wrinkle volume is deepened when W6, and test group is in W4 best results, and at W6
Good effect can be kept；Knowable to SPSS significant difference, experimental group when W2, W4 and W6 wrinkle volume with use before have bright
Significant difference different (P < 0.05), illustrates that the gel containing Cer NS & carnosine submicron liposome has the effect improving wrinkle volume.
2. maximum wrinkle depth rate of change
From in Fig. 2, test group is all decreased obviously at W2, W4 and W6, although matched group has declined, but the lower range of decrease
Degree is weaker than test group.Explanation & carnosine submicron liposome gel Han Cer NS has the effect improving wrinkle depth.
A kind of gel containing Cer NS & carnosine submicron liposome that the present invention provides, its Cer NS & carnosine
Submicron liposome, not only has anti-oxidation efficacy, also has and significantly improve wrinkle volume and the degree of depth, improve skin surface texture
Anti-aging effects.Meanwhile, this liposome possesses the feature that stability is high, water dispersible is good, bio-compatibility is good, can be with cosmetic
Any interworking of product formula.Additionally, the Cer NS & carnosine submicron liposome preparation method of this project is the most controlled, repeat
Property is good.
The described above of disclosed embodiment of this invention, makes professional and technical personnel in the field be capable of or uses this
Bright.Multiple amendment to these embodiments will be apparent from for those skilled in the art, is determined herein
The General Principle of justice can realize without departing from the spirit or scope of the present invention in other embodiments.Therefore, originally
Invention is not intended to be limited to the embodiments shown herein, and is to fit to and principles disclosed herein and features of novelty
The widest consistent scope.
Claims (10)
1. the gel containing Cer NS carnosine submicron liposome, it is characterised in that containing described god in this gel
Through amide 2 & carnosine submicron liposome, by mass percentage this described Cer NS & carnosine submicron liposome by
Following component is constituted:
Cer NS 1%-5%,
Carnosine 1%-8%,
Lipid 15%-35%,
Emulsifying agent 10%-30%,
Co-emulsifier 1%-4%,
Stabilizer 0.2%-1.5%,
Preservative 0.2～1.5%,
Remaining is water.
The gel of a kind of Cer NS & carnosine submicron liposome the most according to claim 1, it is characterised in that by matter
Amount Cer NS & carnosine submicron liposome described in percentages is made up of following component:
Cer NS 2%-4%,
Carnosine 2%-7%
Lipid 20%-30%,
Emulsifying agent 15%-25%,
Co-emulsifier 2%-3%,
Stabilizer 0.5%-1.2%,
Preservative 0.5～1.2%,
Remaining is water.
A kind of gel containing Cer NS & carnosine submicron liposome the most according to claim 1 and 2, its feature exists
In, the mean diameter of the Cer NS & carnosine submicron liposome stated is 50 ~ 200 nm.
A kind of gel containing Cer NS & carnosine submicron liposome the most according to claim 1 and 2, its feature exists
In, described lipid is selected from one or more following combinations: caprylic/capric triglyceride, glyceryl acetate, glycerol stearate
Ester, butyl capryl alcohol salicylate, glycerin polyether-26, octyl dodecanol.
A kind of gel containing Cer NS & carnosine submicron liposome the most according to claim 1 and 2, its feature exists
In, described emulsifying agent selected from one or more combinations following: PEG-8 caprylic/capric glyceride type, stereth-21,
Ceteth-25, PPG-4-ceteth-20, PEG-30 dimerization hydroxy stearic acid ester, PEG-40 castor oil hydrogenated,
Polyglycerolpolyrici.oleate, Pyrusussuriensis smooth olive oil acid esters, the smooth oleate of Pyrusussuriensis, the smooth laurate of Pyrusussuriensis, Pyrusussuriensis smooth sesquialter oleic acid
Ester, Polyoxyethylene Sorbitan Monooleate, polysorbate-60, polysorbate-40, Coco-Glucoside/cocoanut oil alcohol, behenyl alcohol and poly-sweet
Oil-10 five stearates and stearoyl dilactic acid sodium mixture.
A kind of gel containing Cer NS & carnosine submicron liposome the most according to claim 1 and 2, its feature exists
In, described co-emulsifier is selected from one or more combinations following: olive oil PEG-7 esters, polyglycereol-3 two isostearic acid
Ester, ceteth-6.
A kind of gel containing Cer NS & carnosine submicron liposome the most according to claim 1 and 2, its feature exists
In, described stabilizer is selected from one or more combinations following: butanediol, dipropylene glycol, spermol, butylated hydroxytoluene；Described anti-
Rotten agent is selected from one or more combinations following: phenoxyethanol, Sensiva SC50, methyl hydroxybenzoate, propylparaben.
A kind of gel containing Cer NS & carnosine submicron liposome the most according to claim 1 and 2, its feature exists
In, this gel is defying age and/or anti-wrinkle gel.
9. the method for the gel prepared described in claim 1 ~ 8 any one claim, it is characterised in that the method bag
Include below step:
Step (1): using lipid, emulsifying agent, co-emulsifier and stabilizer as oil phase, under the conditions of 60～80 DEG C, mixing is all,
100～300 rpm stirring 10～25 min form uniform mixed solution；
Step (2): the mixed liquor in step (1) adds Cer NS and continues stirring, and mixing time is about 5～15
Min, makes Cer NS be completely dissolved；
Step (3): adding room temperature and the aqueous phase dissolved with carnosine in the mixed solution of step (2), 100～200 rpm constant speed are stirred
Mix 5～10 min；
Step (4): be cooled to by step (3) gained mixed liquor less than 45 DEG C, addition 0.5～the preservative of 1.0%, cooling obtains
Light yellow translucent Cer NS & carnosine submicron liposome；
Step (5): the Cer NS & carnosine submicron liposome of preparation is joined the mixing of the other materials mixing of gel
Thing uniformly mixes, it is thus achieved that containing the gel of Cer NS & carnosine submicron liposome.
The preparation method of gel the most according to claim 9, it is characterised in that the other materials of gel include wetting agent,
One or more mixing in skin moistening oils and fats, surfactant, thickening agent, skin conditioning agent, antiinflammatory, deionized water.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610710922.0A CN106214500A (en) | 2016-08-22 | 2016-08-22 | A kind of gel containing Cer NS & carnosine submicron liposome and preparation method thereof |
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| CN201610710922.0A CN106214500A (en) | 2016-08-22 | 2016-08-22 | A kind of gel containing Cer NS & carnosine submicron liposome and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107375041A (en) * | 2017-09-11 | 2017-11-24 | 苏州纳康生物科技有限公司 | A kind of skin care oleogel containing polypeptide |
| CN112641667A (en) * | 2020-12-29 | 2021-04-13 | 江苏瑞霆生物科技有限公司 | High-stability transparent ceramide nanoemulsion gel and preparation and application thereof |
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| CN104739658A (en) * | 2015-03-04 | 2015-07-01 | 上海应用技术学院 | Ceramide nano-emulsion and preparation method thereof |
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| CN101214198A (en) * | 2007-12-28 | 2008-07-09 | 清华大学 | Ceramide nano liposome preparations and preparation and application thereof |
| CN105813632A (en) * | 2013-08-23 | 2016-07-27 | 科丝美诗株式会社 | Method for preparing nano-emulsion |
| CN103690391A (en) * | 2013-12-27 | 2014-04-02 | 苏州纳康生物科技有限公司 | Ceramide nanoemulsion and preparation method thereof |
| CN104490636A (en) * | 2014-12-12 | 2015-04-08 | 唯美度科技（北京）有限公司 | External preparation using carnosine as active component and preparation method of external preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107375041A (en) * | 2017-09-11 | 2017-11-24 | 苏州纳康生物科技有限公司 | A kind of skin care oleogel containing polypeptide |
| CN112641667A (en) * | 2020-12-29 | 2021-04-13 | 江苏瑞霆生物科技有限公司 | High-stability transparent ceramide nanoemulsion gel and preparation and application thereof |
| CN112641667B (en) * | 2020-12-29 | 2022-03-25 | 江苏瑞霆生物科技有限公司 | High-stability transparent ceramide nanoemulsion gel and preparation and application thereof |
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Application publication date: 20161214 |