CN106199022B - Full-automatic medical treatment analysis meter and its adsorbent equipment - Google Patents
Full-automatic medical treatment analysis meter and its adsorbent equipment Download PDFInfo
- Publication number
- CN106199022B CN106199022B CN201610482391.4A CN201610482391A CN106199022B CN 106199022 B CN106199022 B CN 106199022B CN 201610482391 A CN201610482391 A CN 201610482391A CN 106199022 B CN106199022 B CN 106199022B
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- magnet
- adsorbent equipment
- turntable
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D43/00—Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0437—Cleaning cuvettes or reaction vessels
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- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
The present invention relates to a kind of full-automatic medical treatment analysis meter and its adsorbent equipments.Full-automatic medical treatment analysis meter includes hatch unit, buanch unit and cleaning unit, and buanch unit between hatch unit and cleaning unit for shifting reaction vessel.Cleaning unit includes console, cleaning arm and adsorbent equipment.Console is connect with cleaning arm, for controlling cleaning arm close to or far from adsorbent equipment.Adsorbent equipment, for the magnetic particle in adsorption reaction container, including magnet and stretching structure.Stretching structure is connect with magnet, and magnet can be driven to be bonded with reaction vessel.The full-automatic medical treatment analysis meter and its adsorbent equipment, magnet can be bonded with reaction vessel, eliminate the gap between the magnet of conventional apparatus and reaction vessel, it ensure that reaction vessel is located in the strongest field region of magnet generation, to during cleaning reaction liquid, magnetic particle can be taken away by being adsorbed on the inner wall of reaction vessel tightly without being washed needle, and the loss late of magnetic particle is greatly reduced.
Description
Technical field
The present invention relates to medical treatment analysis meter technical field more particularly to a kind of full-automatic medical treatment analysis meter and its absorption dresses
It sets.
Background technique
In full-automatic medical treatment analysis meter, it usually needs cleaned to the reaction liquid in reaction vessel.Reaction liquid
In the magnetic particle as pharmaceutical carrier it is reusable, therefore, need to retain magnetic particle in wash reaction vessels.
Currently, full-automatic medical treatment analysis meter to reaction vessel by the way of rotatably cleaning, reaction vessel is successively arranged
Cloth sets one for adsorbing the magnet of magnetic particle on turntable at turntable certain position.And it is remoter apart from magnet, magnetic induction is strong
Spend it is smaller, the adsorption capacity of magnet also just it is smaller.There are certain gaps between magnet and reaction vessel, so that magnet is to magnetic particle
Adsorption capacity is insufficient, is easy washed needle during cleaning so as to cause magnetic particle and takes away, the loss late of magnetic particle is higher.
Summary of the invention
Based on this, it is necessary to provide a kind of full-automatic medical treatment analysis meter that can reduce magnetic particle loss late and its absorption dress
It sets.
A kind of adsorbent equipment, for the magnetic particle in adsorption reaction container, including:
Magnet;And
Stretching structure is connect with the magnet, and the magnet can be driven to be bonded with the reaction vessel.
It in one of the embodiments, further include turntable, the turntable is equipped with multiple for placing the reaction vessel
Mounting groove, the mounting groove is circumferentially arranged along the turntable, and the mounting groove and the magnet and the stretching structure
It is arranged in a one-to-one correspondence, accommodating cavity is equipped in the turntable, the accommodating cavity is connected to the mounting groove, the magnet and described is stretched
Shrinking structure is placed in the accommodating cavity, and the stretching structure drives the magnet along the turntable radially adjacent to or far from described
Mounting groove.
The stretching structure includes sliding block and elastic component in one of the embodiments, and the sliding block and the magnet connect
It connects, one end of the elastic component is connected with the slide block, and the other end is connect with the inner wall of the turntable, the mounting groove, described
The radial direction of magnet, the sliding block with the elastic component along the turntable is successively arranged.
It in one of the embodiments, further include abutting member, it can be real between the abutting member and the stretching structure
It now relatively rotates, the abutting member includes support column and idler wheel, and the support column is fixedly arranged on the bottom of the turntable, and described
Magnet is opposite, and the roller housing is set on the support column, and is located in the accommodating cavity;
The bottom of the sliding block is convexly equipped with arc block, and the arc block is raised towards the mounting groove;
When the abutting member and the stretching structure relatively rotate, the idler wheel can be abutted with the arc block, and
Push the sliding block along the turntable radially away from the mounting groove.
The turntable includes external disk, inner disc and bearing in one of the embodiments, the middle part of the external disk and the axis
The outer ring connection held, the inner disc is sheathed in the external disk, and is connect with the inner ring of the bearing;
The mounting groove is intervally arranged on the inner disc, and the external disk and the inner disc are enclosed the accommodating cavity,
The stretching structure is connect with the inner disc, and the abutting member is connect with the external disk.
It in one of the embodiments, further include bottom plate and stabilizer blade, the bottom plate is for carrying the turntable, the stabilizer blade
One end connect with the bottom plate, the other end is fixedly connected with the external disk.
It in one of the embodiments, further include shaft and driving device, the shaft is arranged in the middle part of the inner disc,
The driving device is installed on the bottom plate, and is connect with the shaft, for driving the shaft to rotate.
The driving device is motor in one of the embodiments,.
The elastic component is spring in one of the embodiments, and the spring is located at the sliding block and the turntable
Length between inner wall is less than or equal to the spring not by the length under external force.
A kind of full-automatic medical treatment analysis meter, including hatch unit, buanch unit and cleaning unit, the buanch unit are used for
Reaction vessel is shifted between the hatch unit and the cleaning unit, the cleaning unit includes console, cleaning arm
And any of the above-described kind of adsorbent equipment, the console are connect with the cleaning arm, it is described clear for controlling the cleaning arm lifting
It washes arm to be oppositely arranged with the adsorbent equipment, and can be close to or far from the adsorbent equipment.
Above-mentioned full-automatic medical treatment analysis meter and its adsorbent equipment, magnet can be bonded with reaction vessel, eliminate tradition
Gap between the magnet and reaction vessel of device ensure that reaction vessel is located in the strongest field region of magnet generation, from
And during cleaning reaction liquid, magnetic particle can be by being adsorbed on the inner wall of reaction vessel without being washed tightly
Needle is taken away, and the loss late of magnetic particle is greatly reduced.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the full-automatic medical treatment analysis meter of an embodiment;
Fig. 2 is the structural schematic diagram of the cleaning unit of Fig. 1;
Fig. 3 is the schematic partial cross-sectional view of Fig. 2;
Fig. 4 is the part body schematic diagram of Fig. 2.
Specific embodiment
With reference to the accompanying drawing and specific embodiment is described further cleaning unit and its adsorbent equipment.
With reference to Fig. 1 and Fig. 2, the full-automatic medical treatment analysis meter 10 of an embodiment includes hatch unit 20, transfer list
Member 30 and cleaning unit 40.After the liquid reactions in the reaction vessel 12 being located in hatch unit 20 are complete, buanch unit 30
Reaction vessel 12 will be transferred on cleaning unit 40, the liquid in reaction vessel 12 is cleaned by cleaning unit 40.
The once purged reaction vessel 12 being located on cleaning unit 40 can be also transferred in hatch unit 20 by buanch unit 30.Its
In, the magnetic particle that pharmaceutical carrier is used as in reaction liquid is reusable, therefore, usually requires to retain magnetic particle in cleaning.
Cleaning unit 40 includes console 50, cleaning arm 60 and adsorbent equipment 70.Console 50 is connect with cleaning arm 60, is used
It is gone up and down in control cleaning arm 60.Specifically, console 50 be equipped with guide rail 52, cleaning arm 60 be equipped with sliding block 62, sliding block 62 with
Guide rail 52 connects, and can slide along guide rail 52.Cleaning arm 60 is arc-shaped, is oppositely arranged with adsorbent equipment 70, in console 50
It can be close to or far from adsorbent equipment 70 under effect.Cleaning arm 60 is equipped with washing needle 64, and washing needle 64 is used for intercalation reaction container
Reaction liquid is cleaned in 12.
As shown in figure 3, adsorbent equipment 70 is for the magnetic particle in adsorption reaction container 12, including magnet 100 and flexible
Structure 200.Stretching structure 200 is connect with magnet 100, and magnet 100 can be driven to be bonded with reaction vessel 12.In present embodiment
In, magnet 100 selects magnet.
Currently, full-automatic medical treatment analysis meter can be set when cleaning to reaction vessel at reaction vessel certain position
One for adsorbing the magnet of magnetic particle.And it is remoter apart from magnet, magnetic induction intensity is smaller, and the adsorption capacity of magnet is also just smaller.Magnetic
There are certain gaps between body and reaction vessel, so that magnet is insufficient to the adsorption capacity of magnetic particle, so as to cause magnetic particle clear
It is easy to be taken away by washing lotion needle during washing, the loss late of magnetic particle is higher.
And the adsorbent equipment of present embodiment, magnet can be bonded with reaction vessel, eliminate the magnet of conventional apparatus with
Gap between reaction vessel ensure that reaction vessel is located in the strongest field region of magnet generation, to react in cleaning
During liquid, magnetic particle can be taken away by being adsorbed on the inner wall of reaction vessel tightly without being washed needle, significantly
Reduce the loss late of magnetic particle.
As shown in Figures 2 and 3, adsorbent equipment 70 further includes turntable 300.Turntable 300 is equipped with multiple for placing response
The mounting groove 310 of container 12, mounting groove 310 are circumferentially arranged along turntable 300, and mounting groove 310 and magnet 100 and stretching structure
200 are arranged in a one-to-one correspondence, that is, a magnet 100 and stretching structure 200 are designed with by each mounting groove 310.It is set in turntable 300
There is accommodating cavity 320, accommodating cavity 320 is connected to mounting groove 310.Magnet 100 and stretching structure 200 are placed in accommodating cavity 330, are stretched
Structure 200 drives magnet 100 along turntable 300 radially adjacent to or far from mounting groove 310.
Stretching structure 200 includes sliding block 210 and elastic component 220.Sliding block 210 is connect with magnet 100, and the one of elastic component 220
End is connect with sliding block 210, and the other end is connect with the inner wall of turntable 300.Mounting groove 310, magnet 100, sliding block 210 and elastic component
220 successively arrange along the radial direction of turntable 300.In the present embodiment, elastic component 220 is than mounting groove 310 closer to the rotation of turntable
Turn center.It is appreciated that in other embodiments, also can be reversed each element of arrangement, that is, mounting groove 310 can be than elasticity
Rotation center of the part 220 closer to turntable.
In addition, in the present embodiment, it can be extension spring, or compressed spring that elastic component 220, which is spring,.And
And spring 220 is located at the length between sliding block 210 and the inner wall of turntable 300 less than or equal to spring 220 not by under external force
Length.That is, magnet 100 is also to be bonded with reaction vessel when being put into empty reaction vessel into mounting groove 310.
As shown in Figures 3 and 4, adsorbent equipment 70 further includes abutting member 400.Abutting member 400 and stretching structure 200 it
Between be able to achieve relative rotation.Abutting member 400 includes support column 410 and idler wheel 420.Support column 410 is fixedly arranged on the bottom of turntable 300
Portion, it is opposite with magnet 100.Idler wheel 420 is sheathed on support column 410, and is located in accommodating cavity 320.
The bottom of sliding block 210 is convexly equipped with arc block 212, and arc block 212 is raised towards mounting groove 310.
When abutting member 400 and stretching structure 200 relatively rotate, idler wheel 420 can be abutted with arc block 212, and be pushed
Sliding block 210, radially away from mounting groove 310, reduces the magnetic attraction between magnetic particle and magnet 100, to react along turntable 300
Container 12 can be extracted easily.
Therefore, the effect of abutting member 400 is to separate magnet 100 with reaction vessel 12 after having cleaned reaction liquid,
So that reaction vessel 12 is transferred to hatch unit 20 or other equipment up by buanch unit 30.
In the present embodiment, it as shown in figure 4, abutting member 400 is equipped with 4 altogether, is intervally arranged on turntable 300.It can
To understand, in other embodiments, the number of abutting member 400 can also be for 1,2,3,5 or more.It abuts
The number and installation site of component 400 can according to the actual situation depending on.
With reference to Fig. 2, Fig. 3 and Fig. 4, turntable 300 includes external disk 330, inner disc 340 and bearing 350.In external disk 330
Portion is connect with the outer ring of bearing 350, and inner disc 340 is sheathed in external disk 330, and is connect with the inner ring of bearing 350.
Mounting groove 310 is intervally arranged on inner disc 340, and external disk 330 and inner disc 340 are enclosed accommodating cavity 320, and stretch knot
Structure 200 is connect with inner disc 340, and abutting member 400 is fixed in external disk 330 by screw 430.
As shown in Fig. 2, adsorbent equipment 70 further includes bottom plate 500 and stabilizer blade 600.Bottom plate 500 is used for load-bearing rotary table 300.Branch
One end of foot 600 is connect with bottom plate 500, and the other end is fixedly connected with external disk 330.That is, external disk 330 is fixed disk, do not rotate.Branch
Foot 600 is equipped with 3 altogether, so that entire adsorbent equipment 70 is more firm.
Adsorbent equipment 70 further includes shaft 700 and driving device 800.Shaft 700 is arranged in the middle part of inner disc 340, driving
Device 800 is installed on bottom plate 500, and is connect with shaft 700, is rotated for drive shaft 700.In the present embodiment, turn
One end of axis 700 is threaded through on inner disc 340, and the other end is connect with bottom plate 500 by bearing.Driving device 800 selects motor, electricity
When machine drive shaft 700 rotates, the inner disc 340 being attached thereto can also be rotated together.
In the present embodiment, when the reaction vessel 12 in hatch unit 20 is transferred to cleaning unit 40 by buanch unit 30
After upper, reaction vessel 12 can be rotated together with inner disc 340.When reaction vessel 12 goes to washing 64 underface of needle, inner disc 340
It stops operating, console 50 can control cleaning arm 60 and decline along guide rail 52, until in washing 64 intercalation reaction container 12 of needle.
At this point, magnet 100 is fitted on reaction vessel 12, the magnetic particle in adsorption reaction liquid.After the completion of cleaning, 50 meeting of console
It controls cleaning arm 60 to rise along guide rail 52, washing needle 64 leaves reaction vessel 12.When the reaction vessel 12 cleaned goes to abutting
When at component 400, the arc block 212 on sliding block 210 can be abutted with idler wheel 420, and under the extruding of idler wheel 420, sliding block 210 is inwardly
The center of disk 340 is slided, and drives magnet 100 far from reaction vessel 12, at this point, buanch unit 30 can be by reaction vessel 12 from peace
It is taken out in tankage 310.Moreover, spring 220 at this moment is in compressive state.When inner disc 340 continues to rotate, stretching structure 200 from
After opening abutting member 400, sliding block 210 drives magnet 100 along inner disc 340 radially towards mounting groove under the action of spring 220
310 is mobile.Stretching structure 200 extends, and restores the state that can be extremely bonded with reaction vessel 12.
As shown in Fig. 2, being additionally provided with exciting liquid needle 66 on cleaning arm 60.Exciting liquid needle 66 into reaction vessel 12 for injecting
Exciting liquid.After magnet 100 leaves reaction vessel 12, it can allow in 66 intercalation reaction container 12 of exciting liquid needle and swash to the inside injection
Lotion.
In addition, in other embodiments, magnet can also be operated alone with independent motor or electromagnet.Electricity
It is close or separate to reaction vessel 12 that machine or electromagnet directly drive magnet.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (9)
1. a kind of adsorbent equipment, for the magnetic particle in adsorption reaction container, which is characterized in that including:
Magnet;
Stretching structure is connect with the magnet, and the magnet can be driven to be bonded with the reaction vessel;
Turntable, the turntable are equipped with multiple mounting grooves for being used to place the reaction vessel, and the mounting groove is along the turntable
Be circumferentially arranged, and the mounting groove is arranged in a one-to-one correspondence with the magnet and the stretching structure, is equipped with and is held in the turntable
Chamber is set, the accommodating cavity is connected to the mounting groove, and the magnet and the stretching structure are placed in the accommodating cavity, described to stretch
Shrinking structure drives the magnet along the turntable radially adjacent to or far from the mounting groove;And
Abutting member, including support column and idler wheel, the support column are fixedly arranged on the bottom of the turntable, opposite with the magnet,
The roller housing be set to the support column on, and be located at the accommodating cavity in, stretching structure described in the driven by rotary disc relative to
During the abutting member rotation, the idler wheel can make the stretching structure that the magnet be driven to hold far from the reaction
Device.
2. adsorbent equipment according to claim 1, which is characterized in that the stretching structure includes sliding block and elastic component, institute
It states sliding block to connect with the magnet, one end of the elastic component is connected with the slide block, and the inner wall of the other end and the turntable connects
It connects, the radial direction of the mounting groove, the magnet, the sliding block with the elastic component along the turntable is successively arranged.
3. adsorbent equipment according to claim 2, which is characterized in that the bottom of the sliding block is convexly equipped with arc block, described
Arc block is raised towards the mounting groove;
When the abutting member and the stretching structure relatively rotate, the idler wheel can be abutted with the arc block, and be pushed
The sliding block is along the turntable radially away from the mounting groove.
4. adsorbent equipment according to claim 3, which is characterized in that the turntable includes external disk, inner disc and bearing, described
The middle part of external disk is connect with the outer ring of the bearing, and the inner disc is sheathed in the external disk, and is connected with the inner ring of the bearing
It connects;
The mounting groove is intervally arranged on the inner disc, and the external disk and the inner disc are enclosed the accommodating cavity, described
Stretching structure is connect with the inner disc, and the abutting member is connect with the external disk.
5. adsorbent equipment according to claim 4, which is characterized in that further include bottom plate and stabilizer blade, the bottom plate is for holding
The turntable is carried, one end of the stabilizer blade is connect with the bottom plate, and the other end is fixedly connected with the external disk.
6. adsorbent equipment according to claim 5, which is characterized in that further include shaft and driving device, the shaft is worn
Set on the middle part of the inner disc, the driving device is installed on the bottom plate, and is connect with the shaft, described for driving
Shaft rotation.
7. adsorbent equipment according to claim 6, which is characterized in that the driving device is motor.
8. adsorbent equipment according to claim 2, which is characterized in that the elastic component is spring, and the spring is located at institute
It states the length between the inner wall of sliding block and the turntable and is less than or equal to the spring not by the length under external force.
9. a kind of full-automatic medical treatment analysis meter, which is characterized in that including hatch unit, buanch unit and cleaning unit, described turn
Unit is moved for shifting reaction vessel between the hatch unit and the cleaning unit, the cleaning unit includes control
Platform, cleaning arm and such as adsorbent equipment of any of claims 1-8, the console is connect with the cleaning arm, use
In controlling the cleaning arm lifting, the cleaning arm is oppositely arranged with the adsorbent equipment, and can be close to or far from the absorption
Device.
Priority Applications (1)
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CN201610482391.4A CN106199022B (en) | 2016-06-27 | 2016-06-27 | Full-automatic medical treatment analysis meter and its adsorbent equipment |
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CN201610482391.4A CN106199022B (en) | 2016-06-27 | 2016-06-27 | Full-automatic medical treatment analysis meter and its adsorbent equipment |
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CN106199022A CN106199022A (en) | 2016-12-07 |
CN106199022B true CN106199022B (en) | 2018-11-30 |
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CN107377563B (en) * | 2017-08-24 | 2021-01-08 | 深圳市亚辉龙生物科技股份有限公司 | Magnetic separation cleaning device and working method thereof and liquid injection needle tube |
CN111381058A (en) * | 2018-12-29 | 2020-07-07 | 深圳市帝迈生物技术有限公司 | Magnetic separation device, sample analyzer, and flow type fluorescence immunoassay analyzer |
CN111381054A (en) * | 2018-12-29 | 2020-07-07 | 深圳市帝迈生物技术有限公司 | Magnetic separation device, sample analyzer, and flow type fluorescence immunoassay analyzer |
CN112296049B (en) * | 2019-07-26 | 2022-04-05 | 深圳迎凯生物科技有限公司 | Cleaning method |
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US6884357B2 (en) * | 1995-02-21 | 2005-04-26 | Iqbal Waheed Siddiqi | Apparatus and method for processing magnetic particles |
CN201365164Y (en) * | 2009-03-02 | 2009-12-16 | 北京滨松光子技术股份有限公司 | Magnetic particle processing device |
JP5974230B2 (en) * | 2012-07-12 | 2016-08-23 | 多摩川精機株式会社 | Magnetic stand |
CN103599898B (en) * | 2013-10-29 | 2015-11-25 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device |
CN105628687B (en) * | 2016-02-24 | 2018-08-07 | 南京诺尔曼生物技术有限公司 | A kind of Full-automatic chemiluminescence analyzer |
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