CN106198670B - Improve the buffer solution of pH value of upper digestive tract dynamic monitor detection precision - Google Patents
Improve the buffer solution of pH value of upper digestive tract dynamic monitor detection precision Download PDFInfo
- Publication number
- CN106198670B CN106198670B CN201610571328.8A CN201610571328A CN106198670B CN 106198670 B CN106198670 B CN 106198670B CN 201610571328 A CN201610571328 A CN 201610571328A CN 106198670 B CN106198670 B CN 106198670B
- Authority
- CN
- China
- Prior art keywords
- solution
- glycerine
- value
- buffer solution
- citric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/302—Electrodes, e.g. test electrodes; Half-cells pH sensitive, e.g. quinhydron, antimony or hydrogen electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/38—Cleaning of electrodes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention provides a kind of buffer solution of raising pH value of upper digestive tract dynamic monitor detection precision, is formulated by following composition：Glycerine, 5% glucose solution, citric acid, second alcohol and water, glycerine, second alcohol and water mass ratio be 1.5：2：15, the mass ratio of 5% glucose solution and citric acid is 4：1, when preparing buffer solution, glycerine, ethyl alcohol and water are first mixed into solution A in proportion, then 5% glucose solution and citric acid are compounded into solution B in proportion, solution B is slowly added dropwise into solution A, until the pH value of mixed solution is 3.07 to get buffer solution.The pH electrode probes and reference electrode of the present invention passes through activation process using preceding in buffer solution; electrode reaction is sensitive; hydrogen ion concentration has smaller difference that can be embodied by electrode potential; fine particle is distributed in electrode surface; make electrode surface that there is more fine and smooth lubricity; it can play a protective role to person's windpipe, aqueous solution can also be assembled in electrode surface, to improve monitoring accuracy.
Description
Technical field
The present invention relates to digestive tract power testing equipment field more particularly to a kind of raising pH value of upper digestive tract dynamic monitorings
Instrument detects the buffer solution of precision.
Background technology
Currently, clinically GI Medicine would generally apply pH value of upper digestive tract dynamic monitoring to the monitoring of gastroesophageal reflux
Instrument is monitored the upper digestive tract acid-base value of patient.Electricity is occurred by pH electrode probes and the digestive juice of different pH values
Chemical reaction generates corresponding voltage signal, and the acid-base value information of upper digestive tract is reflected by this voltage signal.Existing skill
PH electrode probes accuracy of detection is low in art, makes the detected value misalignment of pH, cannot real-time and accurately reflect the truth of patient.It is existing
Some pH value of upper digestive tract dynamic monitors, the detection data of output need the personnel of profession that can just understand, the processing to data
It is incomplete.
Invention content
The purpose of the present invention is to provide the buffer solutions that a kind of raising pH value of upper digestive tract dynamic monitor detects precision
And method, to solve the above technical problems.
The technical problems to be solved by the invention are realized using following technical scheme：
It is a kind of improve pH value of upper digestive tract dynamic monitor detection precision buffer solution, which is characterized in that by as follows at
Part is formulated：Glycerine, 5% glucose solution, citric acid, second alcohol and water, glycerine, second alcohol and water mass ratio be 1.5：2：
15, the mass ratio of 5% glucose solution and citric acid is 4：1, when preparing buffer solution, in proportion by glycerine, ethyl alcohol and water first
It is mixed into solution A, then 5% glucose solution and citric acid are compounded into solution B in proportion, solution B is slowly added dropwise to molten
In liquid A, until the pH value of mixed solution is 3.07 to get buffer solution.
The glycerine is support dispersion in buffer solution using aerosil, the mass ratio of glycerine and aerosil
It is 2.03：17.5, glycerine is dissolved in the hot water of 3 times of quality, and hot water temperature is not less than 80 DEG C, then mixed with aerosil
It closes, continuously stirs 5min or more, 10min is refrigerated at a temperature of being placed in -12 DEG C；- 2 DEG C are warming up to, 30min is kept the temperature；It is warming up to 8 again
DEG C, keep the temperature 10min；It is warming up to 20 DEG C again, keeps the temperature 10min, heating and insulating process carry out under negative pressure state three times.
The pressure of the negative pressure state is less than 55kPa.
The method that pH value of upper digestive tract dynamic monitor detects precision, pH value of upper digestive tract are improved using above-mentioned buffer solution
Dynamic monitor includes pH electrode probes and reference electrode, it is characterised in that：
It is impregnated 2 hours before use, pH electrode probes and reference electrode are put into the buffer solution that pH value is 3.07, after taking-up
It is gently dried with chemical analysis filter paper spare；
Glycerine is adsorbed in the hole of aerosil particle, and glycerine passes through freeze-drying process, in filling hole
Gap rate about 45%, is largely adsorbed on silica particles.
PH value of upper digestive tract dynamic monitor provides for the clinical diagnosis of gastroesophageal reflux disease and pathology, mechanism study
A kind of medicine detection means.
The beneficial effects of the invention are as follows：
The pH electrode probes and reference electrode of the present invention passes through activation process, electrode reaction spirit using preceding in buffer solution
Quick, hydrogen ion concentration has smaller difference that can be embodied by electrode potential, and fine particle is distributed in electrode surface, makes electrode
Surface has more fine and smooth lubricity, can play a protective role to person's windpipe, can also assemble aqueous solution in electrode surface,
To improve monitoring accuracy.
Specific implementation mode
In order to make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, tie below
Specific embodiment is closed, the present invention is further explained, but following embodiments are only the preferred embodiment of the present invention, and not all.
Based on the implementation example in the implementation mode, those skilled in the art's obtained other realities without making creative work
Example is applied, protection scope of the present invention is belonged to.
PH value of upper digestive tract dynamic monitor is developed using Hefei Kaili Photoelectric Technology Co., Ltd. and is produced, specification
Model：PDY-L types；The instrument is suitable for gastroesophageal reflux disease and carries out pH value detection.
A method of it improving pH value of upper digestive tract dynamic monitor and detects precision, pH value of upper digestive tract dynamic monitor
Including pH electrode probes and reference electrode,
It is impregnated 2 hours before use, pH electrode probes and reference electrode are put into the buffer solution that pH value is 3.07, after taking-up
It is gently dried with chemical analysis filter paper spare；
It is sweet comprising glycerine, 5% glucose solution, citric acid, second alcohol and water in the buffer solution component that pH value is 3.07
Oily, second alcohol and water mass ratio is 1.5：2：15, the mass ratio of 5% glucose solution and citric acid is 4：1, prepare buffer solution
When, glycerine, ethyl alcohol and water are first mixed into solution A in proportion, then 5% glucose solution is compounded into proportion with citric acid
Solution B is slowly added dropwise into solution A solution B, until the pH value of mixed solution is 3.07 to get buffer solution.
Experiment,
Identical two PDY-L type pH value of upper digestive tract dynamic monitors are taken, number is X monitors, Y monitors respectively,
X monitors impregnate 2 hours before use, pH electrode probes and reference electrode are put into pure water, with change after taking-up
Analytical paper is gently dried spare；Then the standard solution for being 1.5 to pH value carries out 5 detections, every time pH electrodes after detection
Probe and reference electrode are put into pure water and impregnate, and the pH value of 5 detections is respectively 1.46,1.48,1.52,1.49,1.49；
Y monitors before use, pH electrode probes and reference electrode are put into the buffer solution of above-described embodiment impregnate 2 small
When, it is gently dried with chemical analysis filter paper after taking-up spare；Then the standard solution for being 1.5 to pH value carries out 5 detections, every time
PH electrode probes and reference electrode, which are put into buffer solution, after detection impregnates, the pH value of 5 detections is respectively 1.49,1.50,
1.51、1.49、1.50。
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
For personnel it should be appreciated that the present invention is not limited to the above embodiments, described in the above embodiment and specification is only the present invention
Preference, be not intended to limit the present invention, without departing from the spirit and scope of the present invention, the present invention also has various
Changes and improvements, these changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by institute
Attached claims and its equivalent thereof.
Claims (2)
1. a kind of buffer solution improving pH value of upper digestive tract dynamic monitor detection precision, which is characterized in that by following composition
It is formulated：Glycerine, 5% glucose solution, citric acid, second alcohol and water, glycerine, second alcohol and water mass ratio be 1.5：2：
15, the mass ratio of 5% glucose solution and citric acid is 4：1, when preparing buffer solution, in proportion by glycerine, ethyl alcohol and water first
It is mixed into solution A, then 5% glucose solution and citric acid are compounded into solution B in proportion, solution B is slowly added dropwise to molten
In liquid A, until the pH value of mixed solution is 3.07 to get buffer solution；The glycerine is that support dispersion is delaying using aerosil
In fliud flushing, the mass ratio of glycerine and aerosil is 2.03：17.5, glycerine is dissolved in the hot water of 3 times of quality, hot water temperature
Degree is not less than 80 DEG C, is then mixed with aerosil, continuously stirs 5min or more, refrigerated at a temperature of being placed in -12 DEG C
10min；- 2 DEG C are warming up to, 30min is kept the temperature；It is warming up to 8 DEG C again, keeps the temperature 10min；It is warming up to 20 DEG C again, keeps the temperature 10min, three times
Heating and insulating process carry out under negative pressure state.
2. the buffer solution according to claim 1 for improving pH value of upper digestive tract dynamic monitor detection precision, feature
It is：The pressure of the negative pressure state is less than 55kPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610571328.8A CN106198670B (en) | 2016-07-19 | 2016-07-19 | Improve the buffer solution of pH value of upper digestive tract dynamic monitor detection precision |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610571328.8A CN106198670B (en) | 2016-07-19 | 2016-07-19 | Improve the buffer solution of pH value of upper digestive tract dynamic monitor detection precision |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106198670A CN106198670A (en) | 2016-12-07 |
| CN106198670B true CN106198670B (en) | 2018-08-28 |
Family
ID=57494751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610571328.8A Active CN106198670B (en) | 2016-07-19 | 2016-07-19 | Improve the buffer solution of pH value of upper digestive tract dynamic monitor detection precision |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106198670B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1059092A (en) * | 1991-09-20 | 1992-03-04 | 中国科学院电子学研究所 | Sensor for detecting ph value of upper digestive tract |
| CN2212201Y (en) * | 1994-09-01 | 1995-11-08 | 陕西省电子技术研究所 | Automatic analyser for gastric juice |
| JPH07301614A (en) * | 1993-08-05 | 1995-11-14 | Meidensha Corp | Automatic calibration method, measured value correction and cleaning correction method for ph meter |
| CN1768868A (en) * | 2005-10-18 | 2006-05-10 | 陈嘉农 | Anaesthesia possessing lubricant for alimentary tract and respiratory tract endoscope |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9986752B2 (en) * | 2008-05-23 | 2018-06-05 | Lawrence M. Green | Base medicinal liquid formulation for supporting the specific homeostatic acid-base balance of living tissue |
-
2016
- 2016-07-19 CN CN201610571328.8A patent/CN106198670B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1059092A (en) * | 1991-09-20 | 1992-03-04 | 中国科学院电子学研究所 | Sensor for detecting ph value of upper digestive tract |
| JPH07301614A (en) * | 1993-08-05 | 1995-11-14 | Meidensha Corp | Automatic calibration method, measured value correction and cleaning correction method for ph meter |
| CN2212201Y (en) * | 1994-09-01 | 1995-11-08 | 陕西省电子技术研究所 | Automatic analyser for gastric juice |
| CN1768868A (en) * | 2005-10-18 | 2006-05-10 | 陈嘉农 | Anaesthesia possessing lubricant for alimentary tract and respiratory tract endoscope |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106198670A (en) | 2016-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6914838B2 (en) | Diagnostic systems and processes for rapid bacterial infection diagnosis | |
| Agrawal et al. | Noninvasive method for glucose level estimation by saliva | |
| CN104502432B (en) | A kind of sensitive membrane and the screen printing electrode containing the sensitive membrane and its application | |
| CN104359906B (en) | A kind of stabilization, the serum tolal bile acid detection reagent of strong antijamming capability | |
| CN103389333B (en) | A kind of blood sugar device for fast detecting based on composite nanometer material modified electrode | |
| CN104007153A (en) | Electrochemical-luminescence sensor for quickly detecting diphenhydramine hydrochloride by high sensitivity and preparation method thereof | |
| EP1364045A2 (en) | Determining the risk of caries in a patient | |
| CN101865891A (en) | Ambroxol hydrochloride detection method | |
| Komkova et al. | Hydrogen peroxide detection in wet air with a prussian blue based solid salt bridged three electrode system | |
| CN106198670B (en) | Improve the buffer solution of pH value of upper digestive tract dynamic monitor detection precision | |
| CN106264551B (en) | The method for improving pH value of upper digestive tract dynamic monitor detection precision | |
| CN107907470A (en) | The quantitative EM detection method of virion in a kind of cell culture harvest liquid | |
| CN106248759B (en) | The preparation method of pH value of upper digestive tract dynamic monitor buffer | |
| CN108120713A (en) | A kind of Tes-Tape and preparation method thereof | |
| Akaba et al. | Biochemical assessment of the liver in SCD in a tertiary hospital in South-South, Nigeria | |
| CN106198669B (en) | High-end calibration buffer solution used in pH value of upper digestive tract dynamic monitor calibration process | |
| CN106264550B (en) | Low side used in pH value of upper digestive tract dynamic monitor calibration process calibrates buffer | |
| CN106248762B (en) | The pH value calibrating method of pH value of upper digestive tract dynamic monitor | |
| CN204086197U (en) | Saliva Alcohol mental disorders instrument | |
| Bianciardi et al. | Fractal analysis of circulating platelets in type 2 diabetic patients | |
| Anapolle et al. | Continued study of the ultrastructure of the gingiva in the diabetic mouse | |
| CN203048943U (en) | Kit with fungi identification and fast drug sensitivity test functions | |
| CN201828565U (en) | Kit for measuring content of blood sugar | |
| CN106771007A (en) | The detection method and test strips of dexamethasone in a kind of dairy products | |
| CN206177822U (en) | Test paper is diagnosed fast to depression |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |