CN106183227A - Long acting antibiotic type blister packaging materials - Google Patents
Long acting antibiotic type blister packaging materials Download PDFInfo
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- CN106183227A CN106183227A CN201610532989.XA CN201610532989A CN106183227A CN 106183227 A CN106183227 A CN 106183227A CN 201610532989 A CN201610532989 A CN 201610532989A CN 106183227 A CN106183227 A CN 106183227A
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- 230000003115 biocidal effect Effects 0.000 title claims abstract description 56
- 239000005022 packaging material Substances 0.000 title claims abstract description 30
- 239000005030 aluminium foil Substances 0.000 claims abstract description 61
- 239000011230 binding agent Substances 0.000 claims abstract description 38
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000853 adhesive Substances 0.000 claims abstract description 19
- 230000001070 adhesive effect Effects 0.000 claims abstract description 19
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 17
- 229910000108 silver(I,III) oxide Inorganic materials 0.000 claims abstract description 12
- 229920005989 resin Polymers 0.000 claims description 42
- 239000011347 resin Substances 0.000 claims description 42
- 239000003431 cross linking reagent Substances 0.000 claims description 40
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 27
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 24
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 20
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 20
- 235000012239 silicon dioxide Nutrition 0.000 claims description 20
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 16
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 15
- 239000003963 antioxidant agent Substances 0.000 claims description 14
- 230000003078 antioxidant effect Effects 0.000 claims description 14
- 239000011159 matrix material Substances 0.000 claims description 14
- 239000003002 pH adjusting agent Substances 0.000 claims description 14
- JHWIEAWILPSRMU-UHFFFAOYSA-N 2-methyl-3-pyrimidin-4-ylpropanoic acid Chemical compound OC(=O)C(C)CC1=CC=NC=N1 JHWIEAWILPSRMU-UHFFFAOYSA-N 0.000 claims description 10
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 10
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 10
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 10
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 10
- 239000000377 silicon dioxide Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- FGHOOJSIEHYJFQ-UHFFFAOYSA-N (2,4-ditert-butylphenyl) dihydrogen phosphite Chemical compound CC(C)(C)C1=CC=C(OP(O)O)C(C(C)(C)C)=C1 FGHOOJSIEHYJFQ-UHFFFAOYSA-N 0.000 claims description 9
- KOMNUTZXSVSERR-UHFFFAOYSA-N 1,3,5-tris(prop-2-enyl)-1,3,5-triazinane-2,4,6-trione Chemical compound C=CCN1C(=O)N(CC=C)C(=O)N(CC=C)C1=O KOMNUTZXSVSERR-UHFFFAOYSA-N 0.000 claims description 9
- YFICSDVNKFLZRQ-UHFFFAOYSA-N 3-trimethylsilylpropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC[Si](C)(C)C YFICSDVNKFLZRQ-UHFFFAOYSA-N 0.000 claims description 9
- 239000004115 Sodium Silicate Substances 0.000 claims description 9
- 239000005543 nano-size silicon particle Substances 0.000 claims description 9
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 9
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 9
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 8
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 8
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 6
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 6
- 239000004814 polyurethane Substances 0.000 claims description 6
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 238000007766 curtain coating Methods 0.000 claims description 5
- 238000001125 extrusion Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000004332 silver Substances 0.000 claims description 5
- 229910052709 silver Inorganic materials 0.000 claims description 5
- 238000004513 sizing Methods 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 5
- 229920002635 polyurethane Polymers 0.000 claims description 4
- 239000004971 Cross linker Substances 0.000 claims description 3
- 239000003822 epoxy resin Substances 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 229920000647 polyepoxide Polymers 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- ZGBSOTLWHZQNLH-UHFFFAOYSA-N [Mg].S(O)(O)(=O)=O Chemical compound [Mg].S(O)(O)(=O)=O ZGBSOTLWHZQNLH-UHFFFAOYSA-N 0.000 claims 1
- ORVGYTXFUWTWDM-UHFFFAOYSA-N silicic acid;sodium Chemical compound [Na].O[Si](O)(O)O ORVGYTXFUWTWDM-UHFFFAOYSA-N 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 238000007789 sealing Methods 0.000 abstract description 7
- 239000000463 material Substances 0.000 abstract description 4
- 230000000845 anti-microbial effect Effects 0.000 abstract description 3
- 229920000915 polyvinyl chloride Polymers 0.000 abstract description 3
- 239000004800 polyvinyl chloride Substances 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- -1 it includes Substances 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 55
- 241000588724 Escherichia coli Species 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229920001596 poly (chlorostyrenes) Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B33/00—Layered products characterised by particular properties or particular surface features, e.g. particular surface coatings; Layered products designed for particular purposes not covered by another single class
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/714—Inert, i.e. inert to chemical degradation, corrosion
- B32B2307/7145—Rot proof, resistant to bacteria, mildew, mould, fungi
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/80—Medical packaging
Landscapes
- Laminated Bodies (AREA)
- Wrappers (AREA)
Abstract
A kind of long acting antibiotic type blister packaging materials, it includes, base layer, and it is hard that thickness is 20～30 μm or soft state aluminium foil；Adhesive linkage, including double-layer structure, one layer of aluminium foil tack coat being to be bonded in aluminium foil surface, another layer is resin-bonded layer；Antibiotic layer, it is containing nanometer Ag2O or nano-TiO2Aqueous binder, described antibiotic layer is sprayed at described resin-bonded layer side；The present invention coats antibiotic layer at bubble-cap medial surface, and described antibiotic layer is containing nanometer Ag2O or nano-TiO2Aqueous binder, use this antibiotic layer can realize bubble-cap from antibiotic property；Being mixed with nano antibacterial agent in aluminium foil tack coat, antibiotic layer combines antibacterial, improves blister material anti-microbial property；Aluminium foil tack coat side being bonded in aluminium foil surface, carries out sealing, being dried by resin-bonded layer side and polrvinyl chloride or other stiff sheet, hardening time is short, and film forming is fast；Heat-sealing temperature, when 150 DEG C, is more than 9.8 newton/15 millimeter (9.8N/15mm) with the heat seal strength of polyvinyl chloride hard sheet, improves more than 40%.
Description
Technical field
The present invention relates to a kind of blister packaging materials, particularly to a kind of long acting antibiotic type blister packaging materials.
Background technology
Existing blister package covers aluminium foil, is with the pure aluminum foil of 20～30 μm as carrier layer, at top layer printed patterns
And after protective layer, be coated with one layer of PUR through inversion set at medial surface, be used for sealing the organic resin sheets such as PVC, PE, PP, COC
Material, initial sealing temperatures is 140 DEG C.
Owing to directly having sealed tablet in bubble-cap up for safekeeping, the protection of environment in bubble-cap was both required that used PUR possessed
Long-acting viscosity, keeps gnotobasis in requiring again bubble-cap for a long time.And in use, after a bubble-cap is opened, adjacent bubble
The sealing of cover is often affected, and in its bubble-cap, environment is broken, and is unfavorable for that the preservation of tablet uses, easily causes wave
Take.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, it is proposed that a kind of long acting antibiotic type blister packaging materials, it is by bubble
Add antimicrobial component in cover packaging material, thus realize from antibiotic property.
A kind of long acting antibiotic type blister packaging materials, it includes,
Base layer, it is hard that thickness is 20～30 μm or soft state aluminium foil；
Adhesive linkage, including double-layer structure, one layer of aluminium foil tack coat being to be bonded in aluminium foil surface, another layer is resin-bonded
Layer；
Antibiotic layer, it is containing nanometer Ag2O or nano-TiO2Aqueous binder, described antibiotic layer is sprayed at described resin
Tack coat side；
Wherein, described aluminium foil tack coat is made up of aluminium foil binding agent and nano antibacterial agent, and described aluminium foil binder formula is:
Sodium silicate, 37～45%；Silicon dioxide, 1～5%；Aluminium hydroxide, 0.25～1.5%；Sodium dichromate, 0.05～0.5%；Sulfur
Acid magnesium, 0.5～2%；PH adjusting agent, 0～4%；Surplus is water；Described nano antibacterial agent is ZnO/Ag or TiO2/ Ag, Qi Zhongzai
Silver amount is 5～15%, and described nano antibacterial agent is scattered in described aluminium foil binding agent.
Preferably, described long acting antibiotic type blister packaging materials, wherein, described pH adjusting agent is sodium hydroxide, hydrogen-oxygen
Changing potassium, silicic acid and the mixed aqueous solution of phosphoric acid, the ratio of described sodium hydroxide, potassium hydroxide, silicic acid and phosphoric acid is: 1:1:5:1.
Preferably, described long acting antibiotic type blister packaging materials, wherein, described aluminium foil binding agent pH is 5～7.
Preferably, described long acting antibiotic type blister packaging materials, wherein, described resin-bonded layer adhesive therefor is joined
Fang Wei:
Matrix resin, for POE resin, content is 70～85%, and number-average molecular weight is 20000～25000；
Cross-linking agent, for acrylic amide cross-linking agent, content is 5～7%, and described acrylic amide cross-linker molecules formula is:
Assistant crosslinking agent, for Triallyl isocyanurate, content is 1～3%；
Auxiliary antioxidant, for tricresyl phosphite (2,4-di-tert-butyl-phenyl) ester, content is 1～2%；
Viscosifier, for γ-methacryloxypropyl trimethyl silane with described acrylic amide cross-linking agent with quality
Than the mixture for 10:1, content is 5～8%；
Surplus is compatilizer, and described compatilizer is nano silicon.
Preferably, described long acting antibiotic type blister packaging materials, wherein, also include assisted resin, described auxiliary tree
Fat is the one in ethylene vinyl acetate copolymer resin or epoxy resin or two kinds, and content is 5～20%, number-average molecular weight
It is 5000～10000.
Preferably, described long acting antibiotic type blister packaging materials, wherein, described resin-bonded layer adhesive therefor is joined
Fang Wei:
Matrix resin, for POE resin, content is 70%, and number-average molecular weight is 20000；
Assisted resin, for ethylene vinyl acetate copolymer resin, content is 5%, and number-average molecular weight is 5000；
Cross-linking agent, content is 3%；
Assistant crosslinking agent, for Triallyl isocyanurate, content is 3%；
Auxiliary antioxidant, for tricresyl phosphite (2,4-di-tert-butyl-phenyl) ester, content is 2%；
Viscosifier, for γ-methacryloxypropyl trimethyl silane with described acrylic amide cross-linking agent with quality
Than the mixture for 10:1, content is 8%；
Surplus is compatilizer, and described compatilizer is nano silicon.
Preferably, described long acting antibiotic type blister packaging materials, wherein, described resin-bonded layer adhesive therefor is joined
Fang Wei:
Matrix resin, for POE resin, content is 85%, and number-average molecular weight is 25000；
Cross-linking agent, content is 5%；
Assistant crosslinking agent, for Triallyl isocyanurate, content is 1%；
Auxiliary antioxidant, for tricresyl phosphite (2,4-di-tert-butyl-phenyl) ester, content is 1%；
Viscosifier, for γ-methacryloxypropyl trimethyl silane with described acrylic amide cross-linking agent with quality
Than the mixture for 10:1, content is 5%；
Surplus is compatilizer, and described compatilizer is nano silicon.
Preferably, described long acting antibiotic type blister packaging materials, wherein, described antibiotic layer uses containing nanometer Ag2O
Or nano-TiO2Aqueous polyurethane adhesive.
Preferably, described long acting antibiotic type blister packaging materials, wherein, described aluminium foil binding agent uses following steps
Prepare:
1) in reactor, add water, heat up, start stirring；
2) when temperature rises to more than 80 DEG C, be kept stirring for, by sodium silicate, silicon dioxide, aluminium hydroxide, sodium dichromate,
Magnesium sulfate puts in reactor successively, and constant temperature stirs more than 1 hour；
3) it is kept stirring for, cooling, pH adjusting agent is put in reactor, stir 15～30 minutes, regulate pH to 5～7；
4) filter, obtain described aluminium foil binding agent.
Preferably, described long acting antibiotic type blister packaging materials, wherein, described resin-bonded layer uses following steps
Prepare:
1) by matrix resin, cross-linking agent, assistant crosslinking agent mix homogeneously；
2) auxiliary antioxidant, viscosifier and compatilizer use the mode of mixing spraying join 1) in mixture, and
Mixing further；
3) by step 2) mixture prepared pours extruder into and carries out blending extrusion, and temperature controls at 100～160 DEG C, squeezes
Go out thing through curtain coating, cooling, baking oven sizing, traction, coiling process, prepared described resin-bonded layer.
The present invention compared with prior art, possesses following beneficial effect:
1, the present invention coats antibiotic layer at bubble-cap medial surface, and described antibiotic layer is containing nanometer Ag2O or nano-TiO2's
Aqueous binder, uses this antibiotic layer can realize bubble-cap from antibiotic property；
2, being mixed with nano antibacterial agent in aluminium foil tack coat, antibiotic layer combines antibacterial, improves blister material anti-microbial property；
2, aluminium foil tack coat side is bonded in aluminium foil surface, resin-bonded layer side and the polychlorostyrene of antibiotic layer will be coated with
Ethylene or other stiff sheet carry out sealing, being dried, and hardening time is short, and film forming is fast；Heat-sealing temperature is when 150 DEG C, with polyvinyl chloride hard
The heat seal strength of sheet is more than 9.8 newton/15 millimeter (9.8N/15mm), improves more than 40%.
Detailed description of the invention
By particular specific embodiment, embodiments of the present invention being described below, those skilled in the art can be by this explanation
Content disclosed by book understands other advantages and effect of the present invention easily.
Embodiment 1
A kind of long acting antibiotic type blister packaging materials, it includes,
Base layer, it is hard that thickness is 20 μm or soft state aluminium foil；
Adhesive linkage, including double-layer structure, one layer of aluminium foil tack coat being to be bonded in aluminium foil surface, another layer is resin-bonded
Layer；
Antibiotic layer, it is containing nanometer Ag2O or nano-TiO2Aqueous binder, described antibiotic layer is sprayed at described resin
Tack coat side；
Wherein, described aluminium foil tack coat is made up of aluminium foil binding agent and nano antibacterial agent, and described aluminium foil binder formula is:
Sodium silicate, 37%；Silicon dioxide, 5%；Aluminium hydroxide, 1.5%；Sodium dichromate, 0.5%；Magnesium sulfate, 2%；PH adjusting agent,
1%；Surplus is water；Described nano antibacterial agent is ZnO/Ag or TiO2/ Ag, wherein silver carrying amount is 5%, and described nano antibacterial agent divides
Dissipate in described aluminium foil binding agent.
Described pH adjusting agent is the mixed aqueous solution of sodium hydroxide, potassium hydroxide, silicic acid and phosphoric acid, described sodium hydroxide,
The ratio of potassium hydroxide, silicic acid and phosphoric acid is: 1:1:5:1.
Described aluminium foil binding agent pH is 5～7.
Described aluminium foil binding agent is adopted and is prepared by the following steps:
1) in reactor, add water, heat up, start stirring；
2) when temperature rises to more than 80 DEG C, be kept stirring for, by sodium silicate, silicon dioxide, aluminium hydroxide, sodium dichromate,
Magnesium sulfate puts in reactor successively, and constant temperature stirs more than 1 hour；
3) it is kept stirring for, cooling, pH adjusting agent is put in reactor, stir 15 minutes, regulate pH to 5～7；
4) filter, obtain described aluminium foil binding agent.
Further, described resin-bonded layer adhesive therefor formula is:
Matrix resin, for POE resin, content is 70%, and number-average molecular weight is 20000；
Assisted resin, for ethylene vinyl acetate copolymer resin, content is 5%, and number-average molecular weight is 5000；
Cross-linking agent, content is 3%；
Assistant crosslinking agent, for Triallyl isocyanurate, content is 3%；
Auxiliary antioxidant, for tricresyl phosphite (2,4-di-tert-butyl-phenyl) ester, content is 2%；
Viscosifier, for γ-methacryloxypropyl trimethyl silane with described acrylic amide cross-linking agent with quality
Than the mixture for 10:1, content is 8%；
Surplus is compatilizer, and described compatilizer is nano silicon.
Wherein, described antibiotic layer uses containing nanometer Ag2O or nano-TiO2Aqueous polyurethane adhesive.
Described resin-bonded layer is adopted and is prepared by the following steps:
1) by matrix resin, cross-linking agent, assistant crosslinking agent mix homogeneously；
2) auxiliary antioxidant, viscosifier and compatilizer use the mode of mixing spraying join 1) in mixture, and
Mixing further；
3) by step 2) mixture prepared pours extruder into and carries out blending extrusion, and temperature controls at 100 DEG C, extrudate warp
Curtain coating, cooling, baking oven sizing, traction, coiling process, prepare described resin-bonded layer.
Embodiment 2
A kind of long acting antibiotic type blister packaging materials, it includes,
Base layer, it is hard that thickness is 30 μm or soft state aluminium foil；
Adhesive linkage, including double-layer structure, one layer of aluminium foil tack coat being to be bonded in aluminium foil surface, another layer is resin-bonded
Layer；
Antibiotic layer, it is containing nanometer Ag2O or nano-TiO2Aqueous binder, described antibiotic layer is sprayed at described resin
Tack coat side；
Wherein, described aluminium foil tack coat is made up of aluminium foil binding agent and nano antibacterial agent, and described aluminium foil binder formula is:
Sodium silicate, 45%；Silicon dioxide, 1%；Aluminium hydroxide, 0.25%；Sodium dichromate, 0.05%；Magnesium sulfate, 0.5%；PH regulator
Agent, 4%；Surplus is water；Described nano antibacterial agent is ZnO/Ag or TiO2/ Ag, wherein silver carrying amount is 15%, described nano-antibacterial
Agent is scattered in described aluminium foil binding agent.
Described pH adjusting agent is the mixed aqueous solution of sodium hydroxide, potassium hydroxide, silicic acid and phosphoric acid, described sodium hydroxide,
The ratio of potassium hydroxide, silicic acid and phosphoric acid is: 1:1:5:1.
Described aluminium foil binding agent pH is 5～7.
Described aluminium foil binding agent is adopted and is prepared by the following steps:
1) in reactor, add water, heat up, start stirring；
2) when temperature rises to more than 80 DEG C, be kept stirring for, by sodium silicate, silicon dioxide, aluminium hydroxide, sodium dichromate,
Magnesium sulfate puts in reactor successively, and constant temperature stirs more than 1 hour；
3) it is kept stirring for, cooling, pH adjusting agent is put in reactor, stir 30 minutes, regulate pH to 5～7；
4) filter, obtain described aluminium foil binding agent.
Separately, described resin-bonded layer adhesive therefor formula is:
Matrix resin, for POE resin, content is 85%, and number-average molecular weight is 25000；
Cross-linking agent, content is 5%；
Assistant crosslinking agent, for Triallyl isocyanurate, content is 1%；
Auxiliary antioxidant, for tricresyl phosphite (2,4-di-tert-butyl-phenyl) ester, content is 1%；
Viscosifier, for γ-methacryloxypropyl trimethyl silane with described acrylic amide cross-linking agent with quality
Than the mixture for 10:1, content is 5%；
Surplus is compatilizer, and described compatilizer is nano silicon.
Described antibiotic layer uses containing nanometer Ag2O or nano-TiO2Aqueous polyurethane adhesive.
Described resin-bonded layer is adopted and is prepared by the following steps:
1) by matrix resin, cross-linking agent, assistant crosslinking agent mix homogeneously；
2) auxiliary antioxidant, viscosifier and compatilizer use the mode of mixing spraying join 1) in mixture, and
Mixing further；
3) by step 2) mixture prepared pours extruder into and carries out blending extrusion, and temperature controls at 160 DEG C, extrudate warp
Curtain coating, cooling, baking oven sizing, traction, coiling process, prepare described resin-bonded layer.
Embodiment 3
A kind of long acting antibiotic type blister packaging materials, it includes,
Base layer, it is hard that thickness is 25 μm or soft state aluminium foil；
Adhesive linkage, including double-layer structure, one layer of aluminium foil tack coat being to be bonded in aluminium foil surface, another layer is resin-bonded
Layer；
Antibiotic layer, it is containing nanometer Ag2O or nano-TiO2Aqueous binder, described antibiotic layer is sprayed at described resin
Tack coat side；
Wherein, described aluminium foil tack coat is made up of aluminium foil binding agent and nano antibacterial agent, and described aluminium foil binder formula is:
Sodium silicate, 40%；Silicon dioxide, 3%；Aluminium hydroxide, 1%；Sodium dichromate, 0.2%；Magnesium sulfate, 1%；PH adjusting agent, 2%；
Surplus is water；Described nano antibacterial agent is ZnO/Ag or TiO2/ Ag, wherein silver carrying amount is 10%, and described nano antibacterial agent disperses
In described aluminium foil binding agent.
Described pH adjusting agent is the mixed aqueous solution of sodium hydroxide, potassium hydroxide, silicic acid and phosphoric acid, described sodium hydroxide,
The ratio of potassium hydroxide, silicic acid and phosphoric acid is: 1:1:5:1.
Described aluminium foil binding agent pH is 5～7.
Described aluminium foil binding agent is adopted and is prepared by the following steps:
1) in reactor, add water, heat up, start stirring；
2) when temperature rises to more than 80 DEG C, be kept stirring for, by sodium silicate, silicon dioxide, aluminium hydroxide, sodium dichromate,
Magnesium sulfate puts in reactor successively, and constant temperature stirs more than 1 hour；
3) it is kept stirring for, cooling, pH adjusting agent is put in reactor, stir 15～30 minutes, regulate pH to 5～7；
4) filter, obtain described aluminium foil binding agent.
Described resin-bonded layer adhesive therefor formula is:
Matrix resin, for POE resin, content is 80%, and number-average molecular weight is 22000；
Cross-linking agent, for acrylic amide cross-linking agent, content is 6%, and described acrylic amide cross-linker molecules formula is:
Assistant crosslinking agent, for Triallyl isocyanurate, content is 2%；
Auxiliary antioxidant, for tricresyl phosphite (2,4-di-tert-butyl-phenyl) ester, content is 1.5%；
Viscosifier, for γ-methacryloxypropyl trimethyl silane with described acrylic amide cross-linking agent with quality
Than the mixture for 10:1, content is 6%；
Surplus is compatilizer, and described compatilizer is nano silicon.
Also including that assisted resin, described assisted resin are ethylene vinyl acetate copolymer resin, content is 15%, and number is all
Molecular weight is 7000.
Described resin-bonded layer is adopted and is prepared by the following steps:
1) by matrix resin, cross-linking agent, assistant crosslinking agent mix homogeneously；
2) auxiliary antioxidant, viscosifier and compatilizer use the mode of mixing spraying join 1) in mixture, and
Mixing further；
3) by step 2) mixture prepared pours extruder into and carries out blending extrusion, and temperature controls at 140 DEG C, extrudate warp
Curtain coating, cooling, baking oven sizing, traction, coiling process, prepare described resin-bonded layer.
With (aluminium foil side) surface outside above-described embodiment 1, embodiment 2, the bubble-cap of embodiment 3 and common blister with 1 ×
106/cm3Coating is containing colibacillary culture medium, after being placed on 37 DEG C, cultivating 72h under 85% humidity environment, at microscope
The escherichia coli of (resin-bonded layer) inside lower observation bubble-cap, occur in that escherichia coli in common blister, and embodiment 1, implement
Escherichia coli the most do not occur in the blister material of example 2 and embodiment 3.
The principle of above-described embodiment only illustrative present invention and effect thereof, not for limiting the present invention.Any ripe
Above-described embodiment all can be modified under the spirit and the scope of the present invention or change by the personage knowing this technology.Cause
This, have usually intellectual such as complete with institute under technological thought without departing from disclosed spirit in art
All equivalences become are modified or change, and must be contained by the claim of the present invention.
Claims (10)
1. a long acting antibiotic type blister packaging materials, it is characterised in that include,
Base layer, it is hard that thickness is 20～30 μm or soft state aluminium foil；
Adhesive linkage, including double-layer structure, one layer of aluminium foil tack coat being to be bonded in aluminium foil surface, another layer is resin-bonded layer；
Antibiotic layer, it is containing nanometer Ag2O or nano-TiO2Aqueous binder, described antibiotic layer is sprayed at described resin-bonded
Layer side；
Wherein, described aluminium foil tack coat is made up of aluminium foil binding agent and nano antibacterial agent, and described aluminium foil binder formula is: silicic acid
Sodium, 37～45%；Silicon dioxide, 1～5%；Aluminium hydroxide, 0.25～1.5%；Sodium dichromate, 0.05～0.5%；Magnesium sulfate,
0.5～2%；PH adjusting agent, 0～4%；Surplus is water；Described nano antibacterial agent is ZnO/Ag or TiO2/ Ag, wherein silver carrying amount
Being 5～15%, described nano antibacterial agent is scattered in described aluminium foil binding agent.
Long acting antibiotic type blister packaging materials the most according to claim 1, it is characterised in that described pH adjusting agent is hydrogen-oxygen
Change sodium, potassium hydroxide, silicic acid and the mixed aqueous solution of phosphoric acid, the ratio of described sodium hydroxide, potassium hydroxide, silicic acid and phosphoric acid
For: 1:1:5:1.
Long acting antibiotic type blister packaging materials the most according to claim 2, it is characterised in that described aluminium foil binding agent pH is
5～7.
Long acting antibiotic type blister packaging materials the most according to claim 1, it is characterised in that used by described resin-bonded layer
Adhesive formula is:
Matrix resin, for POE resin, content is 70～85%, and number-average molecular weight is 20000～25000；
Cross-linking agent, for acrylic amide cross-linking agent, content is 5～7%, and described acrylic amide cross-linker molecules formula is:
Assistant crosslinking agent, for Triallyl isocyanurate, content is 1～3%；
Auxiliary antioxidant, for tricresyl phosphite (2,4-di-tert-butyl-phenyl) ester, content is 1～2%；
Viscosifier, for γ-methacryloxypropyl trimethyl silane with described acrylic amide cross-linking agent with mass ratio be
The mixture of 10:1, content is 5～8%；
Surplus is compatilizer, and described compatilizer is nano silicon.
Long acting antibiotic type blister packaging materials the most according to claim 4, it is characterised in that also include assisted resin, institute
Stating assisted resin is the one in ethylene vinyl acetate copolymer resin or epoxy resin or two kinds, and content is 5～20%, number
Average molecular weight is 5000～10000.
Long acting antibiotic type blister packaging materials the most according to claim 5, it is characterised in that used by described resin-bonded layer
Adhesive formula is:
Matrix resin, for POE resin, content is 70%, and number-average molecular weight is 20000；
Assisted resin, for ethylene vinyl acetate copolymer resin, content is 5%, and number-average molecular weight is 5000；
Cross-linking agent, content is 3%；
Assistant crosslinking agent, for Triallyl isocyanurate, content is 3%；
Auxiliary antioxidant, for tricresyl phosphite (2,4-di-tert-butyl-phenyl) ester, content is 2%；
Viscosifier, for γ-methacryloxypropyl trimethyl silane with described acrylic amide cross-linking agent with mass ratio be
The mixture of 10:1, content is 8%；
Surplus is compatilizer, and described compatilizer is nano silicon.
Long acting antibiotic type blister packaging materials the most according to claim 4, it is characterised in that used by described resin-bonded layer
Adhesive formula is:
Matrix resin, for POE resin, content is 85%, and number-average molecular weight is 25000；
Cross-linking agent, content is 5%；
Assistant crosslinking agent, for Triallyl isocyanurate, content is 1%；
Auxiliary antioxidant, for tricresyl phosphite (2,4-di-tert-butyl-phenyl) ester, content is 1%；
Viscosifier, for γ-methacryloxypropyl trimethyl silane with described acrylic amide cross-linking agent with mass ratio be
The mixture of 10:1, content is 5%；
Surplus is compatilizer, and described compatilizer is nano silicon.
Long acting antibiotic type blister packaging materials the most according to claim 1, it is characterised in that described antibiotic layer uses and contains
Nanometer Ag2O or nano-TiO2Aqueous polyurethane adhesive.
Long acting antibiotic type blister packaging materials the most according to claim 1, it is characterised in that described aluminium foil binding agent uses
Following steps prepare:
1) in reactor, add water, heat up, start stirring；
2) when temperature rises to more than 80 DEG C, it is kept stirring for, by sodium silicate, silicon dioxide, aluminium hydroxide, sodium dichromate, sulphuric acid
Magnesium puts in reactor successively, and constant temperature stirs more than 1 hour；
3) it is kept stirring for, cooling, pH adjusting agent is put in reactor, stir 15～30 minutes, regulate pH to 5～7；
4) filter, obtain described aluminium foil binding agent.
Long acting antibiotic type blister packaging materials the most according to claim 4, it is characterised in that described resin-bonded layer is adopted
It is prepared by the following steps:
1) by matrix resin, cross-linking agent, assistant crosslinking agent mix homogeneously；
2) auxiliary antioxidant, viscosifier and compatilizer use the mode of mixing spraying join 1) in mixture, go forward side by side one
Step mixing；
3) by step 2) mixture prepared pours extruder into and carries out blending extrusion, and temperature controls at 100～160 DEG C, extrudate
Through curtain coating, cooling, baking oven sizing, traction, coiling process, prepare described resin-bonded layer.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115352148A (en) * | 2022-10-17 | 2022-11-18 | 宁波时代铝箔科技股份有限公司 | Separable packaging material, preparation method thereof and packaging container |
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| CN201099449Y (en) * | 2007-09-30 | 2008-08-13 | 李宝玉 | PTP aluminum foil for environment-friendly food and medicine package |
| CN103434214A (en) * | 2013-09-23 | 2013-12-11 | 上海海顺新型药用包装材料股份有限公司 | Antibacterial self-cleaning PTP (Poly Terephthalic acid) aluminum foil and preparation method thereof |
| CN104140769A (en) * | 2014-08-06 | 2014-11-12 | 苏州卓越工程塑料有限公司 | Hot melt adhesive for bubble cap packaging |
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2016
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2786010Y (en) * | 2005-05-23 | 2006-06-07 | 孙长志 | Nano compound packing material |
| CN201099449Y (en) * | 2007-09-30 | 2008-08-13 | 李宝玉 | PTP aluminum foil for environment-friendly food and medicine package |
| CN103434214A (en) * | 2013-09-23 | 2013-12-11 | 上海海顺新型药用包装材料股份有限公司 | Antibacterial self-cleaning PTP (Poly Terephthalic acid) aluminum foil and preparation method thereof |
| CN104140769A (en) * | 2014-08-06 | 2014-11-12 | 苏州卓越工程塑料有限公司 | Hot melt adhesive for bubble cap packaging |
Cited By (1)
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| CN115352148A (en) * | 2022-10-17 | 2022-11-18 | 宁波时代铝箔科技股份有限公司 | Separable packaging material, preparation method thereof and packaging container |
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