CN106179541A - Biochip hybridization machine - Google Patents
Biochip hybridization machine Download PDFInfo
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- CN106179541A CN106179541A CN201610216534.7A CN201610216534A CN106179541A CN 106179541 A CN106179541 A CN 106179541A CN 201610216534 A CN201610216534 A CN 201610216534A CN 106179541 A CN106179541 A CN 106179541A
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- biochip
- loading plate
- motor
- belt wheel
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50855—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using modular assemblies of strips or of individual wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/10—Means to control humidity and/or other gases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention relates to technical field of automation equipment, particularly relate to biochip hybridization machine, including mounting base with for carrying the loading plate of biochip, described mounting base be arranged over cleaning area and hatch district, described in hatch district and be provided with incubating device；Described biochip hybridization machine also includes turnover driving mechanism and horizontal drive mechanism, described turnover driving mechanism is connected with described loading plate and drives described loading plate to carry out overturning to carry out being carried out described biochip in described cleaning area, and described horizontal drive mechanism is connected with described loading plate and drives described loading plate to move back and forth between district in described cleaning area and described hatching.The biochip hybridization machine of the present invention, whole process during work realizes automation mechanized operation, and at least integrate biochip hybridization, biochip cleans, need not manual intervention, it is ensured that operation is more accurate, and save manpower and time resource, raising efficiency, prevents biochip by biological pollution.
Description
Technical field
The present invention relates to technical field of automation equipment, particularly relate to biochip hybridization machine.
Background technology
The hybridization of existing biochip, cleaning, drying device are typically independent device, every kind of instrument
A kind of function, such as some Hybridization Ovens, chip cleaning device, chip drying instrument can only be realized
Deng, these instrument common problems are: one, the turnover between each instrument, it is still desirable to too much
Manual intervention, can bring error because of manual operation, and waste of manpower and time resource, inefficiency,
And too much also can there is the risk of biological pollution in contact biochip；Two, each instrumental function unification,
Structure is complicated；Three, simple function instrument there is also certain use limitation and deficiency, such as, cleans
The cleanest problem, centrifugal drying can damage hybridization conjugate, causes the problem etc. of detection mistake.
Summary of the invention
Present invention aims to the deficiencies in the prior art provide and a kind of integrate hybridization, clean
Biochip hybridization machine.
For achieving the above object, the technical scheme is that biochip hybridization machine, including installing the end
Plate and for carrying the loading plate of biochip, being arranged over cleaning area and hatch district of described mounting base,
Described district of hatching is provided with incubating device；Described biochip hybridization machine also includes turnover driving mechanism and water
Flat drive mechanism, described turnover driving mechanism is connected with described loading plate and drives described loading plate described
Carry out in cleaning area overturning to carry out described biochip is carried out, described horizontal drive mechanism and institute
State loading plate connect and drive described loading plate to move back and forth between district in described cleaning area and described hatching.
Preferably, described turnover driving mechanism includes and the first driving source and described first providing power
Driving source connect with transmission power the first power driving module and be used for being connected described power transmission group
Part and the rotating shaft of described loading plate.
Preferably, described first driving source is the first motor, and described first power driving module includes first
Belt, the first belt wheel and the second belt wheel, described first motor is installed on described loading plate, described rotating shaft
The first end be connected with described loading plate, described first belt wheel is connected with the main shaft of described first motor, institute
State the second belt wheel to be connected with the second end of described rotating shaft, described first belt be set around described first belt wheel and
Between second belt wheel.
Preferably, described loading plate includes fixed frame and the returning face plate being located in described fixed frame, described the
One motor is installed on described fixed frame on described fixed frame and is provided with shaft hole, and one end of described rotating shaft passes institute
State shaft hole and fixing with described returning face plate be connected.
Preferably, described horizontal drive mechanism includes that the second driving source providing power is driven with described second
Dynamic source connects the second power driving module with transmission power and guide rod, described fixed frame side along its length
To offering guide hole, described guide rod is separately fixed at described installation through the two ends of described guide hole and this guide rod
The two ends in floor length direction, described second power transmission group is also connected with described fixed frame.
Preferably, described second driving source is the second motor, and described second power driving module includes second
Belt, the 3rd belt wheel and the 4th belt wheel, described second motor is installed on described mounting base, and described
Three belt wheels are connected with the main shaft of described second motor, described 4th belt wheel be installed on described mounting base away from
The side of described second motor, described second belt be set around described 3rd belt wheel and described 4th belt wheel it
Between and fixing with described fixed frame be connected.
Preferably, described incubating device includes shell, heat generating member, cover plate and elevating mechanism, described heating
Part is installed on described mounting base and hatches district described in being positioned at, described cover plate be located at described in hatch district
Top, described elevating mechanism is connected with described cover plate and is used for driving described cover plate to move up and down, described outside
Clamshell is located at described heat generating member, described cover plate and the outside of described elevating mechanism.
Preferably, described elevating mechanism includes the 3rd motor, cam and lifting pushing block, described 3rd motor
Hatching the top in district described in being fixed on, described cam is connected with the main shaft drives of described 3rd motor, described
The bottom of lifting pushing block is connected and is positioned at the side of described 3rd motor, described lifting pushing block with described cover plate
Side end near described 3rd motor offers end-face hole, and described cam is positioned at described end-face hole and institute
The inwall of the cam surface and described end-face hole of stating cam abuts.
Preferably, described incubating device also includes that temperature controller, described temperature controller are connected with described heat generating member.
Preferably, hatch described in and in district, be additionally provided with the drying machine that the gas in described shell is dried
Structure.
Preferably, described drier is to be installed on the fan on described shell or air exhauster.
Preferably, described mounting base offers the logical liquid bath corresponding with position, described cleaning area, described logical
The lower section of liquid bath connects waste liquid pool, and described waste liquid pool offers waste liquid outlet.
Preferably, described cleaning area is provided with liquid-adding device, described liquid-adding device include liquid feeding pin and with institute
State liquid feeding pin connect and offer in the mechanical hand driving described liquid feeding pin to move, described liquid feeding pin and blow
Pore.
Beneficial effects of the present invention: the biochip hybridization machine of the present invention, during work, biochip is placed
On loading plate, first add reactant liquor on the surface of biochip, then driven by horizontal drive mechanism
Dynamic loading plate moves to hatch district from cleaning area, hatches the mechanism of hatching arranged in district and carries out biochip
Incubation with heat hybridizes；After having hybridized, horizontal drive mechanism drives loading plate to move to clean from hatching district
District, after adding washing liquid, turnover driving mechanism drives loading plate to carry out flip horizontal so that biochip table
Washing liquid on face flows away, can repeatable operation, thus realize biochip being hatched hybridization and cleaning；
After completing the cleaning to biochip, being finally dried, whole process realizes automation mechanized operation, and extremely
Integrate hybridization less, clean, it is not necessary to manual intervention, it is ensured that operation is more accurate, save manpower and
Time resource, raising efficiency, prevent biochip by biological pollution.
Accompanying drawing explanation
Fig. 1 is the perspective view of the biochip hybridization machine of the present invention.
Fig. 2 is the three-dimensional knot that the turnover driving mechanism of the biochip hybridization machine of the present invention is connected with loading plate
Structure schematic diagram.
Fig. 3 is the stereochemical structure signal during returning face plate rollover states of the biochip hybridization machine of the present invention
Figure.
Fig. 4 is the three-dimensional knot that the horizontal drive mechanism of the biochip hybridization machine of the present invention is connected with loading plate
Structure schematic diagram
Fig. 5 is the cut away view of the biochip hybridization machine of the present invention.
Reference includes:
District is hatched in 10 mounting base 11 cleaning areas 12
13 lead to liquid bath 20 loading plate 21 fixed frame
22 returning face plate 30 liquid-adding device 31 liquid feeding pins
32 mechanical hand 40 incubating device 41 shells
42 heat generating member 43 cover plate 44 elevating mechanisms
45 temperature controller 50 turnover driving mechanism 51 first motors
52 first belt 53 first belt wheel 54 second belt wheels
55 rotating shaft 60 horizontal drive mechanism 61 second motors
62 second belt 63 the 3rd belt wheel 64 the 4th belt wheels
65 guide rod 70 drier 80 waste liquid pools
81 waste liquid outlet 211 shaft hole 212 guide holes
221 groove 222 shell fragment 321 X-axis drive mechanisms
322 Y-axis drive structure 323 Z axis drive mechanism 441 the 3rd motor
442 cams 443 lift pushing block 4431 end-face hole.
Detailed description of the invention
Embodiments of the invention are described below in detail, and the example of described embodiment is shown in the drawings, wherein
The most same or similar label represents same or similar element or has same or like function
Element.The embodiment described below with reference to accompanying drawing 1～5 is exemplary, it is intended to be used for explaining this
Bright, and be not considered as limiting the invention.
In describing the invention, it is to be understood that term " length ", " width ", " on ", D score,
"front", "rear", "left", "right", " vertically ", " level ", " top ", " end " " interior ", " outward " etc. refer to
The orientation shown or position relationship, for based on orientation shown in the drawings or position relationship, are for only for ease of description
The present invention and simplification describe rather than indicate or imply that the device of indication or element must have specific side
Position, with specific azimuth configuration and operation, be therefore not considered as limiting the invention.
Additionally, term " first ", " second " are only used for describing purpose, and it is not intended that instruction or dark
Show relative importance or the implicit quantity indicating indicated technical characteristic.Thus, define " first ",
The feature of " second " can express or implicitly include one or more this feature.In the present invention
Description in, " multiple " are meant that two or more, unless otherwise expressly limited specifically.
In the present invention, unless otherwise clearly defined and limited, term " install ", " being connected ", " even
Connect ", the term such as " fixing " should be interpreted broadly, connect for example, it may be fixing, it is also possible to be removable
Unload connection, or integral；Can be to be mechanically connected, it is also possible to be electrical connection；Can be to be joined directly together,
Can also be indirectly connected to by intermediary, can be connection or the phase of two elements of two element internals
Interaction relation.For the ordinary skill in the art, can understand as the case may be above-mentioned
Term concrete meaning in the present invention.
As shown in Figures 1 to 5, the biochip hybridization machine that embodiments of the invention provide, including installing
Base plate 10 and for carrying the loading plate 20 of biochip, being arranged over of described mounting base 10 is cleaned
District 11 and hatch district 12, described in hatch district 12 and be provided with incubating device 40；Described biochip hybridization machine
Also include that turnover driving mechanism 50 and horizontal drive mechanism 60, described turnover driving mechanism 50 hold with described
Support plate 20 connects and drives described loading plate 20 to carry out overturning to carry out described in described cleaning area 11
Biochip is carried out, and described horizontal drive mechanism 60 is connected with described loading plate 20 and drives described
Loading plate 20 moves back and forth between district 12 in described cleaning area 11 and described hatching.During work, biological core
Sheet is positioned on loading plate 20, first adds reactant liquor on the surface of biochip, is then driven by level
Motivation structure 60 drives loading plate 20 to move to hatch district 12 from cleaning area 11, hatches setting in district 12
Hatch mechanism and biochip is carried out incubation with heat hybridization；After having hybridized, horizontal drive mechanism 60 drives
Loading plate 20 moves to cleaning area 11 from hatching district 12, and turnover driving mechanism 50 drives loading plate 20 to enter
Row flip horizontal so that the washing liquid in biochip surface flows away, can repeatable operation, thus realize to life
Thing chip carries out hatching hybridization and cleaning；After completing the cleaning to biochip, finally it is dried, work
Make whole process and realize automation mechanized operation, and at least integrate hybridization, clean, it is not necessary to manual intervention,
Guaranteeing to operate more accurate, save manpower and time resource, raising efficiency, prevents biochip from being given birth to
Thing pollutes.
In the present embodiment, described turnover driving mechanism 50 include with provide power the first driving source and
Described first driving source connects the first power driving module with transmission power and described dynamic with being used for being connected
The rotating shaft 55 of power transmission component and described loading plate 20.Concrete, use the first driving source to be led to by power
Crossing the first power driving module to be delivered in rotating shaft 55, then rotating shaft 55 rotates, and drives with it even simultaneously
The loading plate 20 connect rotates, and loading plate 20 makes the liquid on biochip flow away when rotating, repeatedly turn
Dynamic loading plate 20 reaches to clean the purpose of biochip.
In the present embodiment, shown in Fig. 2～3, the first embodiment of turnover driving mechanism is: upset
Drive mechanism 50 specifically include as first drive source the first motor 51 and by the first belt 52,
First power driving module of first belt wheel the 53, second belt wheel 54 composition and rotating shaft 55, described loading plate
20 include fixed frame 21 and the returning face plate 22 being located in described fixed frame 21, and described fixed frame 21 is provided with
Shaft hole 211, the first end of described rotating shaft 55 through described shaft hole 211 and with described returning face plate 22
Fixing connection, described first motor 51 is installed on described fixed frame 21, described first belt wheel 53 and institute
The main shaft stating the first motor 51 connects, and described second belt wheel 54 is connected with the second end of described rotating shaft 55,
Described first belt 52 is set around between described first belt wheel 53 and the second belt wheel 54.Concrete, biological
Chip is positioned on loading plate 20 and fixes, and when biochip is carried out by needs, overturns driving machine
Structure 50 controls loading plate 20 and carries out overturning thus realize the cleaning to biochip.Turnover driving mechanism 50
Work process be: the first motor 51 works, and drives the first belt wheel 53 to rotate, and the first belt wheel 53 drives
First belt 52 rotates around the first belt wheel 53 and the second belt wheel 54, due to the second belt wheel 54 and rotation
Connecting, the second belt wheel 54 drives rotating shaft 55 to rotate, and is connected owing to rotating shaft 55 is fixing with returning face plate 22 again,
Returning face plate 22 can be driven when so rotating shaft 55 rotates to overturn, when returning face plate 22 overturns, so that upset
The liquid on biochip placed on plate 22 flows away, and repeatedly overturns described returning face plate 22 it is thus possible to right
Biochip is carried out, automation mechanized operation, and work efficiency is high, good working effect.
Second embodiment of turnover driving mechanism 50 is it may also is that first the driving of turnover driving mechanism 50
Dynamic source can be cylinder, and coordinates the first driving force member composition, and cylinder is certain skewed is fixed on
On the downside of returning face plate 22, the piston rod of cylinder and a power end of the first driving force member connect, the first power
Another power end of driving member bottom surface with returning face plate 22 again is connected, so, by the piston rod of cylinder
Stretch and control to drive returning face plate 22 to carry out flip horizontal action, thus be equally capable of returning face plate
The cleaning of the biochip on 22.
Certainly, the first driving force member the most singly can be carried by first belt the 52, first belt wheel 53, second
Wheel 54 composition, it is also possible to be chain and sprocket wheel composition, or be that screw mandrel forms with travelling nut, this kind of
Power driving module all can realize power transmission, may act as the first power transmission in the present embodiment
Part uses.
In the present embodiment, described horizontal drive mechanism 60 includes the second driving source and the institute providing power
Second driving source of stating connects the second power driving module with transmission power and guide rod 65, described fixed frame
21 offer guide hole 212 along its length, and described guide rod 65 is through described guide hole 212 and this guide rod
The two ends of 65 are separately fixed at the two ends of described mounting base 10 length direction, described second power transmission
Group is also connected with described fixed frame 21.Concrete, use the second driving source to be passed by the second power by power
Dynamic component passes is on fixed frame 21, so that fixed frame 21 moves along guide rod 65 for guiding,
Owing to returning face plate 22 is connected with fixed frame 21, then returning face plate 22 also followed by fixed frame 21 and moves
Dynamic, and then realize driving the biochip on returning face plate 22 to move.
In the present embodiment, shown in Fig. 4, the first embodiment of horizontal drive mechanism 60 is:
State horizontal drive mechanism 60 include as second drive source the second motor 61 and by the second belt 62,
Second power driving module of the 3rd belt wheel the 63, the 4th belt wheel 64 composition and guide rod 65, described fixed frame
21 offer guide hole 212 along its length, and described guide rod 65 is through described guide hole 212 and this guide rod
The two ends of 65 are separately fixed at the two ends of described mounting base 10 length direction, and described second motor 61 is pacified
Being loaded on described mounting base 10, described 3rd belt wheel 63 is connected with the main shaft of described second motor 61,
Described 4th belt wheel 64 is installed on the described mounting base 10 side away from described second motor 61, described
Second belt 62 be set around between described 3rd belt wheel 63 and described 4th belt wheel 64 and with described fixed frame
21 fixing connections.During horizontal drive mechanism 60 specific works, the second motor 61 works, and drives the 3rd band
Wheel 63 rotation, the 3rd belt wheel 63 drives the second belt 62 around the 3rd belt wheel 63 and the 4th belt wheel 64
Rotating, the second belt 62 is fixing with fixed frame 21 to be connected, and the second belt wheel 54 drives fixed frame 21 to move,
Owing to fixed frame 21 offers the guide hole 212 coordinated with guide rod 65, then fixed frame 21 is in the mistake of movement
Cheng Zhonghui moves along guide rod 65, thus drives returning face plate 22 to move horizontally along guide rod 65, Jin Erke
So that the biochip on returning face plate 22 is moved to hatching district 12 from cleaning area 11, hatch and set in district 12
The incubating device 40 put carries out incubation with heat work to this biochip.
Second embodiment of horizontal drive mechanism 60 is it may also is that horizontal drive mechanism 60 can also be
The second driving force member formed by electric cylinder, linear module and screw mandrel and nut screw connection forms, such as,
Air cylinder driven screw mandrel rotates, and the nut that screw mandrel connects moves, and nut can drive fixed frame 21 to move,
Fixed frame 21 can move with linear module for wire, is capable of equally driving fixed frame 21 He
Biochip on returning face plate 22 and returning face plate 22 backhauls between district 12 in cleaning area 11 and hatching
Dynamic, and then realize the cleaning to biochip and hatch work.
Certainly, the second driving force member can also is that chain and sprocket wheel composition, or belt and belt pulley set
Becoming, this kind of power driving module all can realize power transmission, may act as second in the present embodiment
Driving force member uses.
It addition, in this embodiment, returning face plate 22 upper surface offers several side by side or array
Groove 221, and shell fragment 222 is set on groove 221, so biochip is clamped by shell fragment 222
In groove 221, thus realize fixing biochip, during upset returning face plate 22 and drive biological core
Sheet is when cleaning area 11 and hatching moves back and forth between district 12, it is to avoid biochip produces and departs from or position
Moving, scientific structure design is reasonable, practical.
In the present embodiment, shown in Fig. 5, described incubating device 40 include shell 41, heat generating member 42,
Cover plate 43 and elevating mechanism 44, described heat generating member 42 is installed on described mounting base 10 and is positioned at and sets
Hatch in district in described, described cover plate 43 be located at described in hatch the top in district 12, described elevating mechanism 44
Being connected with described cover plate 43 and be used for driving described cover plate 43 to move up and down, described shell 41 covers at institute
State heat generating member 42, described cover plate 43 and the outside of described elevating mechanism 44.Concrete, work as horizontal drive
Mechanism 60 drives whole loading plate 20 to move to when hatching in district 12, starts incubating device 40 and works,
First elevating mechanism 44 drives cover plate 43 to decline, until cover plate 43 covers the life placed on returning face plate 22
The top of thing chip, then heat generating member 42 is positioned at the lower section of returning face plate 22 and generates heat, due to heat generating member
42, cover plate 43, elevating mechanism 44 and carry the loading plate 20 of biochip and be in shell 41
Inside, heat generating member 42 can promote the temperature within whole shell 41, thus temperature is reached applicable
The temperature that biological core is hatched, hatches hybridization to biochip, after completing, again by elevator
Structure 44 drives cover plate 43 to rise, and so circulates, it is achieved automation mechanized operation.
Certainly, in other embodiments, it is also possible to be the incubating device 40 of other structures, as long as can be real
The most airtight space is to be heated to temperature be suitable for the condition that biochip is hatched.
In the present embodiment, shown in Fig. 5, described elevating mechanism 44 includes the 3rd motor 441, cam
442 and lifting pushing block 443, described 3rd motor 441 be fixed on described in hatch the top in district 12, described
Cam 442 is connected with the main shaft drives of described 3rd motor 441, the bottom of described lifting pushing block 443 with
Described cover plate 43 connects and is positioned at the side of described 3rd motor 441, and described lifting pushing block 443 is near institute
The side end stating the 3rd motor 441 offers end-face hole 4431, and described cam 442 is positioned at described end-face hole
The 4431 interior and described cam surfaces of cam 442 abut with the inwall of described end-face hole 4431.Elevating mechanism
During 44 specific works, the 3rd motor 441 starts, and the main shaft of the 3rd motor 441 drives connected convex
Wheel 442 rotation, cam 442 is when rotating, and the top jaw face of cam 442 can form a peak
With a minimum point, abut with the inwall of end-face hole 4431 due to the cam surface of cam 442 again, the most convex
Wheel 442 can support the inwall of end-face hole 4431 all the time when rotating, and drives whole lifting pushing block 443
Carry out raising and lowering, drive lifting pushing block when the top jaw face of cam 442 forms a peak
443 rise to peak；Drive lifting to push away when the top jaw face of cam 442 forms a minimum point
Block 443 drops to minimum point, and so, the cover plate 43 being connected with lifting pushing block 443 also can followed by rising
And decline, thus realize controlling cover plate 43 and cover the biochip prevented on the returning face plate 22 of loading plate 20.
More specifically, end-face hole 4431 can be through hole or blind hole.
Certainly, elevating mechanism 44 can also be cylinder, and the piston rod of cylinder is connected with the top of cover plate 43,
Cover plate 43 raising and lowering is controlled by the flexible realization of the piston rod of cylinder.
In the present embodiment, shown in Fig. 5, described incubating device 40 also includes temperature controller 45, described
Temperature controller 45 is connected with described heat generating member 42.Concrete, when heat generating member 42 makes shell 41 inside add
During the temperature that heat is hatched to applicable biochip, temperature controller 45 can real-time monitor temperature value, Jin Erfang
Only heat generating member 42 continues heating so that the temperature within shell 41 is maintained at the state of constant temperature, it is ensured that raw
Thing chip is sent out and is hatched stable carrying out, and is not affected by too high or too low temperature.
In the present embodiment, shown in Fig. 5, described in hatch and be additionally provided with in district 12 in described shell 41
The drier 70 that is dried of gas, i.e. drier 70 is arranged on and hatches in district 12, to biology
Chip is dried process.Concrete, when biochip is dried by needs, first drive in level
Under the driving of motivation structure 60, returning face plate 22 movable type carrying biochip is hatched in district 12, and control
Cover plate 43 processed is in the position on top, it is not necessary to cover biochip, then starts drier 70 right
Air in shell 41 is dried, thus realizes being dried biochip.
Preferably, described drier 70 for fan or air exhauster and is installed on described shell 41；
During work, the gas in fan or air exhauster suction shell 41, air-flow is formed on the surface of biochip,
And under the heating work of heat generating member 42 coordinates, form thermal current on the surface of biochip, thus realize
Biochip is dried；Biochip will not be caused damage by dry run.
Certainly, in other embodiments, drier 70 can also be centrifuge, by centrifugal side
Biochip is dried by formula.
In the present embodiment, the setting of drier 70 makes whole biochip hybridization machine collection hybridize, clearly
Washing and be dried in one, fully realize automation mechanized operation, manipulation is carried out by controller, it is not necessary to artificial
Intervene；It is not only simple in structure compact, and simple to operation, efficiency is high, it is simple to unmanned management and life
Thing chip industry.
In the present embodiment, shown in Fig. 5, described mounting base 10 offers and described cleaning area 11
The logical liquid bath 13 that position is corresponding, the lower section of described logical liquid bath 13 connects waste liquid pool 80, described waste liquid pool
Waste liquid outlet 81 is offered on 80.Concrete, when returning face plate 22 overturns, on its biochip liquid
Flowing in waste liquid pool 80 through logical liquid bath 13, waste liquid pool 80 carries out centralized recovery, eventually passes waste liquid and goes out
The positions that mouth 81 is expelled to set carry out pollution-freeization process, reasonable in design, it is to avoid waste liquid is to environment
Pollute.
In the present embodiment, shown in Fig. 1, described cleaning area 11 is provided with liquid-adding device 30, described
Liquid-adding device 30 includes liquid feeding pin 31 and is connected with described liquid feeding pin 31 and for driving described liquid feeding pin
The mechanical hand 32 that 31 move, offers gas hole (not shown) in described liquid feeding pin 31.Concrete, add
Liquid pin 31 can be drawn cleanout fluid and add on biochip, and mechanical hand 32 controls liquid feeding pin 31 three
Move in dimension space, thus realize liquid feeding；Offer gas hole in liquid feeding pin 31 then can connect
Air pump, produces air pressure by air pump and is blown away by liquid unnecessary for biochip surface, follow-up to life
Being dried of thing chip.
Shown in Fig. 1, the mechanical hand 32 in the present embodiment is driven by X-axis drive mechanism 321, Y-axis
Structure 322 and Z axis drive mechanism 323 form, and drive structure by X-axis drive mechanism 321, Y-axis
322 and the cooperation of Z axis drive mechanism 323 can automatically control liquid feeding pin 31 at X-axis, Y-axis and Z
Three directions of axle are moved.
In sum understand the present invention be that there is above-described good characteristic, made its use on,
Promote the usefulness not having in conventional art and there is practicality, become the product of a great practical value.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all at this
Any amendment, equivalent or the improvement etc. made within the thought of invention and principle, should be included in this
Within the protection domain of invention.
Claims (12)
1. biochip hybridization machine, including mounting base with for carrying the loading plate of biochip, it is special
Levy and be: described mounting base be arranged over cleaning area and hatch district, described in hatch district and be provided with and hatch
Device；Described biochip hybridization machine also includes turnover driving mechanism and horizontal drive mechanism, described upset
Drive mechanism be connected with described loading plate and drive described loading plate carry out overturning in described cleaning area into
Described biochip is carried out by row, and described horizontal drive mechanism is connected with described loading plate and drives institute
State loading plate to move back and forth between district in described cleaning area and described hatching.
Biochip hybridization machine the most according to claim 1, it is characterised in that: described upset drives
Mechanism includes being connected with described first driving source with the first driving source providing power transmitting the of power
One power driving module and with for being connected described power driving module and the rotating shaft of described loading plate.
Biochip hybridization machine the most according to claim 2, it is characterised in that: described first drives
Source is the first motor, and described first power driving module includes the first belt, the first belt wheel and the second belt wheel,
Described first motor is installed on described loading plate, and the first end of described rotating shaft is connected with described loading plate,
Described first belt wheel is connected with the main shaft of described first motor, described second belt wheel and the second of described rotating shaft
End connects, and described first belt is set around between described first belt wheel and the second belt wheel.
Biochip hybridization machine the most according to claim 3, it is characterised in that: described loading plate bag
Including fixed frame and the returning face plate being located in described fixed frame, described first motor is installed on described fixed frame
Described fixed frame is provided with shaft hole, the first end of described rotating shaft through described shaft hole and with described returning face plate
Fixing connection.
Biochip hybridization machine the most according to claim 4, it is characterised in that: described horizontal drive
Mechanism includes providing the second driving source of power to be connected with described second driving source to transmit the second of power
Power driving module and guide rod, described fixed frame offers guide hole along its length, and described guide rod is worn
The two ends crossing described guide hole and this guide rod are separately fixed at the two ends of described mounting base length direction, described
Second power transmission group is also connected with described fixed frame.
Biochip hybridization machine the most according to claim 5, it is characterised in that: described second drives
Source is the second motor, and described second power driving module includes the second belt, the 3rd belt wheel and the 4th belt wheel,
Described second motor is installed on described mounting base, described 3rd belt wheel and the main shaft of described second motor
Connecting, described 4th belt wheel is installed on the described mounting base side away from described second motor, and described the
Two belts are set around between described 3rd belt wheel and described 4th belt wheel and fix with described fixed frame and are connected.
Biochip hybridization machine the most according to claim 1, it is characterised in that: described incubating device
Including shell, heat generating member, cover plate and elevating mechanism, described heat generating member is installed on described mounting base also
Hatch district described in being positioned at, described cover plate be located at described in hatch the top in district, described elevating mechanism is with described
Cover plate connects and is used for driving described cover plate to move up and down, and described jacket is located at described heat generating member, described
Cover plate and the outside of described elevating mechanism.
Biochip hybridization machine the most according to claim 7, it is characterised in that: described elevating mechanism
Including the 3rd motor, cam and lifting pushing block, described 3rd motor be fixed on described in hatch the top in district,
Described cam is connected with the main shaft drives of described 3rd motor, the bottom of described lifting pushing block and described cover plate
Connecting and be positioned at the side of described 3rd motor, described lifting pushing block is near the side end of described 3rd motor
Offering end-face hole, described cam is positioned at the cam surface of described end-face hole and described cam and described end face
The inwall in hole abuts.
Biochip hybridization machine the most according to claim 7, it is characterised in that: described incubating device
Also include that temperature controller, described temperature controller are connected with described heat generating member.
Biochip hybridization machine the most according to claim 7, it is characterised in that hatch district described in:
On be additionally provided with the drier that the gas in described shell is dried；Described drier is for being installed on
Fan on described shell or air exhauster.
11. according to the biochip hybridization machine described in any one of claim 1～10, it is characterised in that: institute
Stating mounting base and offer the logical liquid bath corresponding with position, described cleaning area, the lower section of described logical liquid bath connects
There is waste liquid pool, described waste liquid pool offers waste liquid outlet.
12. according to the biochip hybridization machine described in any one of claim 1～10, it is characterised in that: institute
Stating cleaning area and be provided with liquid-adding device, described liquid-adding device includes liquid feeding pin and is connected also with described liquid feeding pin
Gas hole is offered in the mechanical hand driving described liquid feeding pin to move, described liquid feeding pin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610216534.7A CN106179541B (en) | 2016-04-08 | 2016-04-08 | Biochip hybridization machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610216534.7A CN106179541B (en) | 2016-04-08 | 2016-04-08 | Biochip hybridization machine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106179541A true CN106179541A (en) | 2016-12-07 |
| CN106179541B CN106179541B (en) | 2018-10-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610216534.7A Active CN106179541B (en) | 2016-04-08 | 2016-04-08 | Biochip hybridization machine |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111487400A (en) * | 2020-05-22 | 2020-08-04 | 南京岚煜生物科技有限公司 | Time-resolved fluorescence immunoassay analyzer |
| CN111849750A (en) * | 2020-06-23 | 2020-10-30 | 福建工程学院 | Automatic detection system of genotyping chip |
| CN115684609A (en) * | 2022-12-30 | 2023-02-03 | 港龙生物技术（深圳）有限公司 | Biochip pretreatment operation system and method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101334402A (en) * | 2007-06-26 | 2008-12-31 | 上海裕隆生物科技有限公司 | Full-automatic biological chips detection system |
| CN104215783A (en) * | 2014-05-21 | 2014-12-17 | 凯和生物科技(上海)有限公司 | Strip type immune fully-automatic analyzer |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101334402A (en) * | 2007-06-26 | 2008-12-31 | 上海裕隆生物科技有限公司 | Full-automatic biological chips detection system |
| CN104215783A (en) * | 2014-05-21 | 2014-12-17 | 凯和生物科技(上海)有限公司 | Strip type immune fully-automatic analyzer |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111487400A (en) * | 2020-05-22 | 2020-08-04 | 南京岚煜生物科技有限公司 | Time-resolved fluorescence immunoassay analyzer |
| CN111849750A (en) * | 2020-06-23 | 2020-10-30 | 福建工程学院 | Automatic detection system of genotyping chip |
| CN115684609A (en) * | 2022-12-30 | 2023-02-03 | 港龙生物技术（深圳）有限公司 | Biochip pretreatment operation system and method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106179541B (en) | 2018-10-30 |
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